pentylenetetrazole has been researched along with Benign Infantile Myoclonic Epilepsy in 27 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 7.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "The action of ethosuximide (125 or 250 mg/kg, IP) against picrotoxin-induced seizures (3-6 mg/kg, IP) was assessed in rats 12, 18, 25, and 90 days old." | 7.68 | Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. ( Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J, 1993) |
| "Dravet syndrome is characterized by multiple seizure types: generalized tonic-clonic, focal, myoclonic, and absence seizures." | 5.72 | Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels. ( Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M, 2022) |
| "The present study was designed to investigate the importance of sex differences in the interaction between dizocilpine (MK-801) pretreatment and acute cold-restraint stress (CRS) in pentylenetetrazole (PTZ)-induced seizures in Swiss albino mice." | 3.74 | Influence of sex on the interaction between dizocilpine (MK-801) pretreatment and acute cold-restraint stress in epilepsy susceptibility in an animal study. ( Aksu, F; Inan, SY, 2008) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 3.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| "The objective of this study was to evaluate the interaction of the novel antiepileptic drug (AED), topiramate (TPM), with conventional AEDs against amygdala-kindled seizures in rats and pentylenetetrazol-induced convulsions in mice." | 3.72 | Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. ( Borowicz, KK; Czuczwar, SJ; Duda, AM; Luszczki, JJ, 2003) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "The interaction of 7-nitroindazole (7-NI), a nitric oxide synthase (NOS) inhibitor, with the protective activity of conventional antiepileptics against pentylenetetrazol (PTZ)-induced seizures was tested in mice." | 3.70 | 7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J, 2000) |
| "The action of ethosuximide (125 or 250 mg/kg, IP) against picrotoxin-induced seizures (3-6 mg/kg, IP) was assessed in rats 12, 18, 25, and 90 days old." | 3.68 | Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. ( Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J, 1993) |
| "Dravet syndrome is characterized by multiple seizure types: generalized tonic-clonic, focal, myoclonic, and absence seizures." | 1.72 | Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels. ( Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M, 2022) |
| "Here, we hypothesize that Dravet syndrome may be treated by either enhancing Nav1." | 1.56 | NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome. ( Bosma, M; Braun, KPJ; Inserra, M; Koeleman, BPC; Rivara, M; Rook, MB; Singh, S; van 't Slot, RH; Verhoeven-Duif, NM; Vetter, I; Volkers, L; Weuring, WJ, 2020) |
| "It has been established that febrile seizures and its extended syndromes like generalized epilepsy with febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes." | 1.46 | Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2 ( Kang, JQ; Liu, Z; Macdonald, RL; Warner, TA, 2017) |
| "Caffeine treatment at a daily dose of 10 and/or 20 mg/kg, sc was executed during postnatal days 7-11." | 1.39 | Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. ( Kubová, H; Mareš, P; Tchekalarova, JD, 2013) |
| "Cardiac arrhythmias are a proposed cause for some cases of SUDEP, yet the susceptibility and potential mechanism of arrhythmogenesis in Dravet syndrome remain unknown." | 1.39 | Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome. ( Auerbach, DS; Clawson, BC; Isom, LL; Jones, J; Lenk, GM; Meisler, MH; Offord, J; Ogiwara, I; Parent, JM; Yamakawa, K, 2013) |
| " When drugs were dissolved in vehicles which themselves did not exert effects on seizure susceptibility, the most important factors which influenced drug potencies were: (1) bishaped dose-response curves, i." | 1.28 | The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. ( Fassbender, CP; Hönack, D; Löscher, W; Nolting, B, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Riban, V | 1 |
| Heulard, I | 1 |
| Reversat, L | 1 |
| Si Hocine, H | 1 |
| Verleye, M | 1 |
| Jankovic, MJ | 1 |
| Kapadia, PP | 1 |
| Krishnan, V | 1 |
| Weuring, WJ | 1 |
| Singh, S | 1 |
| Volkers, L | 1 |
| Rook, MB | 1 |
| van 't Slot, RH | 1 |
| Bosma, M | 1 |
| Inserra, M | 1 |
| Vetter, I | 1 |
| Verhoeven-Duif, NM | 1 |
| Braun, KPJ | 1 |
| Rivara, M | 1 |
| Koeleman, BPC | 1 |
| Warner, TA | 1 |
| Liu, Z | 1 |
| Macdonald, RL | 2 |
| Kang, JQ | 2 |
| Huang, X | 1 |
| Zhou, C | 1 |
| Tian, M | 1 |
| Shen, W | 1 |
| Verdier, K | 1 |
| Pimenta, A | 1 |
| Silva, LF | 1 |
| Hoffmann, MS | 1 |
| Gerbatin, Rda R | 1 |
| Fiorin, Fda S | 1 |
| Dobrachinski, F | 1 |
| Mota, BC | 1 |
| Wouters, AT | 1 |
| Pavarini, SP | 1 |
| Soares, FA | 1 |
| Fighera, MR | 1 |
| Royes, LF | 1 |
| Tchekalarova, JD | 1 |
| Kubová, H | 1 |
| Mareš, P | 3 |
| Auerbach, DS | 1 |
| Jones, J | 1 |
| Clawson, BC | 1 |
| Offord, J | 1 |
| Lenk, GM | 1 |
| Ogiwara, I | 1 |
| Yamakawa, K | 1 |
| Meisler, MH | 1 |
| Parent, JM | 1 |
| Isom, LL | 1 |
| Popławska, M | 1 |
| Wróblewska, D | 1 |
| Borowicz, KK | 5 |
| de Oliveira, CC | 1 |
| de Oliveira, CV | 1 |
| Grigoletto, J | 1 |
| Ribeiro, LR | 1 |
| Funck, VR | 1 |
| Grauncke, AC | 1 |
| de Souza, TL | 1 |
| Souto, NS | 1 |
| Furian, AF | 1 |
| Menezes, IR | 1 |
| Oliveira, MS | 1 |
| Inan, SY | 1 |
| Aksu, F | 1 |
| Löscher, W | 2 |
| González-Ramírez, M | 1 |
| Razo-Juárez, LI | 1 |
| Sauer-Ramírez, JL | 1 |
| González-Trujano, ME | 1 |
| Salgado-Ceballos, H | 1 |
| Orozco-Suarez, S | 1 |
| Piskorska, B | 1 |
| Stępniak, B | 1 |
| Czuczwar, SJ | 4 |
| Luszczki, JJ | 2 |
| Duda, AM | 1 |
| Nagaraja, RY | 1 |
| Grecksch, G | 1 |
| Reymann, KG | 1 |
| Schroeder, H | 1 |
| Becker, A | 1 |
| Yilmaz, I | 1 |
| Sezer, Z | 1 |
| Kayir, H | 1 |
| Uzbay, TI | 1 |
| Holmes, GL | 1 |
| Albala, BJ | 1 |
| Moshé, SL | 1 |
| Velísková, J | 1 |
| Velísek, L | 2 |
| Rokyta, R | 1 |
| Micianiková, D | 1 |
| Luszczki, J | 1 |
| Kleinrok, Z | 1 |
| Frye, CA | 1 |
| Muscatiello, NA | 1 |
| Halonen, T | 1 |
| Pitkänen, A | 1 |
| Partanen, J | 1 |
| Hyttinen, JM | 1 |
| Riekkinen, PJ | 1 |
| Naquet, R | 1 |
| Veresová, S | 1 |
| Pôbisová, H | 1 |
| Hönack, D | 1 |
| Fassbender, CP | 1 |
| Nolting, B | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Shandra, AA | 1 |
| Makul'kin, RF | 1 |
| Godlevskiĭ, LS | 1 |
1 review available for pentylenetetrazole and Benign Infantile Myoclonic Epilepsy
| Article | Year |
|---|---|
Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans.
Topics: Animals; Anticonvulsants; Antiretroviral Therapy, Highly Active; Data Interpretation, Statistical; D | 2009 |
1 trial available for pentylenetetrazole and Benign Infantile Myoclonic Epilepsy
| Article | Year |
|---|---|
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Avoidance Learning; Convulsants; | 2012 |
25 other studies available for pentylenetetrazole and Benign Infantile Myoclonic Epilepsy
| Article | Year |
|---|---|
Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels.
Topics: Animals; Anticonvulsants; Calcium Channels, T-Type; Dioxolanes; Disease Models, Animal; Electroencep | 2022 |
Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Epilepsies, Myoclonic; Mice; Mon | 2019 |
NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Hu | 2020 |
Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2
Topics: Age Factors; Animals; Body Temperature; Convulsants; Disease Models, Animal; Electroencephalography; | 2017 |
Overexpressing wild-type γ2 subunits rescued the seizure phenotype in Gabrg2
Topics: Action Potentials; Animals; Convulsants; Electric Stimulation; Epilepsies, Myoclonic; Humans; In Vit | 2017 |
Treadmill exercise protects against pentylenetetrazol-induced seizures and oxidative stress after traumatic brain injury.
Topics: Animals; Brain; Brain Chemistry; Brain Injuries; Convulsants; Electrodes, Implanted; Electroencephal | 2013 |
Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
Topics: Aging; Animals; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Myoc | 2013 |
Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiac Electrophysiology; Death, Sudden, Cardiac; | 2013 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Ani | 2015 |
Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Epi | 2016 |
Influence of sex on the interaction between dizocilpine (MK-801) pretreatment and acute cold-restraint stress in epilepsy susceptibility in an animal study.
Topics: Animals; Cold Temperature; Dizocilpine Maleate; Epilepsies, Myoclonic; Female; Male; Mice; Mice, Inb | 2008 |
Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Chromatography, High Pressu | 2010 |
Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2003 |
Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling, and kindling-related learning deficits.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzoates; Binding Sites; Dose-Response Relationship, | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Chi-Square Distribution; Depressive | 2007 |
Effect of a single brief seizure on subsequent seizure susceptibility in the immature rat.
Topics: Animals; Disease Susceptibility; Electroshock; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; | 1984 |
Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Ethosuxim | 1993 |
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; | 2000 |
3alpha,5alpha-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Estrus; Female; G | 2001 |
Amino acid levels in cerebrospinal fluid of rats after administration of pentylenetetrazol.
Topics: Amino Acids; Animals; Catheterization; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Toni | 1992 |
Epileptic manifestations and influence on sleep in the baboon Papio papio.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Tonic-C | 1991 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. II. The effects of MK-801.
Topics: Aging; Amino Acids; Animals; Dizocilpine Maleate; Epilepsies, Myoclonic; Male; Pentylenetetrazole; P | 1991 |
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models.
Topics: Animals; Anticonvulsants; Epilepsies, Myoclonic; Female; Infusions, Intravenous; Injections, Subcuta | 1991 |
[The hippocampus as the determinant structure generating epileptic activity during korazol kindling].
Topics: Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Dimethyl Sulfoxide; Electroencephalography; Ep | 1985 |