pentylenetetrazole has been researched along with Audiogenic Epilepsy in 12 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 7.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| "KM rats exhibited increased seizure severity relative to Wistar rats, and the death of KM rats was observed in 2." | 5.38 | [The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats]. ( Kim, KKh; Lavrent'eva, VV; Lukomskaia, NIa; Magazanik, LG; Vataev, SI; Zaĭtsev, AV; Zhabko, EP, 2012) |
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 3.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| "In mice VGD afforded complete protection against maximal electroshock (MES)-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz "psychomotor" seizures with median effective dose (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively." | 3.71 | Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. ( Bialer, M; Isoherranen, N; White, HS; Woodhead, JH, 2001) |
| " No differences in convulsive thresholds to Metrazol were obtained, however, between untreated Swiss-Webster mice and mice of the same strain made audiosuseptible by rubidium chloride intake or magnesium deficiency." | 3.66 | Metrazol thresholds in inbred and non-inbred audiosensitive mice. ( Alexander, GJ; Alexander, RB; Kopeloff, LM, 1981) |
| "Treatment with finasteride increased seizure susceptibility and depression due to decreased progesterone and elevated estrogen levels coupled with decreased monoamine and elevated corticosterone levels." | 1.72 | Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy. ( Goel, RK; Pahwa, P; Singh, T, 2022) |
| "KM rats exhibited increased seizure severity relative to Wistar rats, and the death of KM rats was observed in 2." | 1.38 | [The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats]. ( Kim, KKh; Lavrent'eva, VV; Lukomskaia, NIa; Magazanik, LG; Vataev, SI; Zaĭtsev, AV; Zhabko, EP, 2012) |
| "Seizures are a common phenotype in all of these neurological disorders, yet the underlying molecular mechanism(s) of seizure induction and propagation remain largely unknown." | 1.36 | Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures. ( Malter, JS; Westmark, CJ; Westmark, PR, 2010) |
| "Third, forebrain seizures were induced in genetically epilepsy-prone rats (GEPRs) by microinfusion of bicuculline into the area tempestas (AT), while brainstem seizures in GEPRs were induced by audiogenic stimulation." | 1.32 | Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats. ( Browning, RA; Clough, RW; Eells, JB; Jobe, PC, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pahwa, P | 1 |
| Singh, T | 1 |
| Goel, RK | 1 |
| Kim, KKh | 1 |
| Zaĭtsev, AV | 1 |
| Lavrent'eva, VV | 1 |
| Zhabko, EP | 1 |
| Vataev, SI | 1 |
| Lukomskaia, NIa | 1 |
| Magazanik, LG | 1 |
| Stafstrom, CE | 1 |
| Ockuly, JC | 1 |
| Murphree, L | 1 |
| Valley, MT | 1 |
| Roopra, A | 1 |
| Sutula, TP | 1 |
| Westmark, CJ | 1 |
| Westmark, PR | 1 |
| Malter, JS | 1 |
| Rubio, C | 1 |
| Rubio-Osornio, M | 1 |
| Retana-Márquez, S | 1 |
| Verónica Custodio, ML | 1 |
| Paz, C | 1 |
| SWINYARD, EA | 1 |
| CASTELLION, AW | 1 |
| FINK, GB | 1 |
| GOODMAN, LS | 1 |
| KESNER, RP | 1 |
| O'KELLY, LI | 1 |
| THOMAS, GJ | 1 |
| Eells, JB | 1 |
| Clough, RW | 1 |
| Browning, RA | 1 |
| Jobe, PC | 1 |
| White, HS | 3 |
| Watson, WP | 1 |
| Hansen, SL | 1 |
| Slough, S | 1 |
| Perregaard, J | 1 |
| Sarup, A | 1 |
| Bolvig, T | 1 |
| Petersen, G | 1 |
| Larsson, OM | 1 |
| Clausen, RP | 1 |
| Frølund, B | 1 |
| Falch, E | 1 |
| Krogsgaard-Larsen, P | 1 |
| Schousboe, A | 1 |
| Alexander, GJ | 1 |
| Kopeloff, LM | 1 |
| Alexander, RB | 1 |
| Stöhr, T | 1 |
| Kupferberg, HJ | 1 |
| Stables, JP | 1 |
| Choi, D | 1 |
| Harris, RH | 1 |
| Kohn, H | 1 |
| Walton, N | 1 |
| Isoherranen, N | 1 |
| Woodhead, JH | 1 |
| Bialer, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy[NCT05512130] | Early Phase 1 | 18 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | ||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pentylenetetrazole and Audiogenic Epilepsy
| Article | Year |
|---|---|
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; | 2010 |
11 other studies available for pentylenetetrazole and Audiogenic Epilepsy
| Article | Year |
|---|---|
Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Epilepsy, Reflex; Female; Horses; Mice; Pentylenetetrazole; P | 2022 |
[The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats].
Topics: Animals; Anticonvulsants; Cyclohexylamines; Epilepsy, Reflex; Excitatory Amino Acid Antagonists; Fem | 2012 |
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models.
Topics: Animals; Anticonvulsants; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2009 |
Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures.
Topics: Acoustic Stimulation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Convulsants; Down | 2010 |
Some neurophysiological and neuropharmacological characteristics of audiogenic-seizure-susceptible mice.
Topics: Animals; Epilepsy, Reflex; Mice; Pentylenetetrazole; Seizures | 1963 |
EFFECTS OF CORTICAL SPREADING DEPRESSION AND DRUGS UPON AUDIOGENIC SEIZURES IN RATS.
Topics: Brain; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Epilepsy; Epilepsy, Reflex | 1965 |
Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats.
Topics: Animals; Brain Stem; Electroshock; Epilepsy, Reflex; Immunohistochemistry; Pentylenetetrazole; Prose | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, | 2005 |
Metrazol thresholds in inbred and non-inbred audiosensitive mice.
Topics: Acoustic Stimulation; Animals; Convulsants; Epilepsy, Reflex; Magnesium Deficiency; Male; Mice; Pent | 1981 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Pa | 2007 |
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2001 |