pentylenetetrazole has been researched along with Ataxia in 28 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of the inhibitor of the expression of Heat shock proteins 70 kDa (Hsp70), quercetin on seizures and movement disorders induced by N-methyl D-aspartate (NMDA) or pentylenetetrazole in adult rats Wistar were investigated using behavioral methods." | 7.76 | [EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures]. ( Ekimova, IV; Feĭzulaev, BA; Guzhova, IV; Nitsinskaia, LE; Pastukhov, IuF, 2010) |
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 7.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "These results show that the anesthetics propofol and 2,6-di-sec-butylphenol may be substituted in the para position with a 1-hydroxy-2,2,2-trifluoroethyl moiety and the resulting molecules have anticonvulsant activity in the 6 Hz model while exhibiting less toxicity (ataxia) than the parent 2,6-dialkylphenols." | 3.77 | The anticonvulsant effects of propofol and a propofol analog, 2,6-diisopropyl-4-(1-hydroxy-2,2,2-trifluoroethyl)phenol, in a 6 Hz partial seizure model. ( Baker, MT, 2011) |
| "Effects of the inhibitor of the expression of Heat shock proteins 70 kDa (Hsp70), quercetin on seizures and movement disorders induced by N-methyl D-aspartate (NMDA) or pentylenetetrazole in adult rats Wistar were investigated using behavioral methods." | 3.76 | [EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures]. ( Ekimova, IV; Feĭzulaev, BA; Guzhova, IV; Nitsinskaia, LE; Pastukhov, IuF, 2010) |
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 3.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| "Four dihydropyridine calcium channel antagonists were compared for their ability to protect against the hyperexcitability produced in mice by withdrawal from chronic ethanol treatment and to protect against seizures due to bicuculline or pentylenetetrazol." | 3.71 | Selectivity of the protective effects of dihydropyridine calcium channel antagonists against the ethanol withdrawal syndrome. ( Little, HJ; Watson, WP, 2002) |
| "LY 300164 [7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4, 5H)-2,3-benzodiazepine], an antagonist of AMPA/kainate receptors, at 5 mg/kg exerted a significant anticonvulsant effect, as regards seizure and afterdischarge durations in amygdala-kindled seizures in rats." | 3.70 | Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J; Szadkowski, M, 1999) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "Aromatic and heterocyclic esters of 1-methyl-4-piperidinol and 1,4-dimethyl-4-piperidinol and aromatic esters of (dialkylamino)alkanols were prepared and evaluated for antiepileptic activity by the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for minimal central neurotoxicity by the rotorod ataxia test." | 3.67 | Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters. ( Creveling, CR; Daly, JW; Hollingsworth, EB; Lewandowski, G; Waters, JA, 1986) |
| "High anxiety also leads to higher motor incoordination (as assessed by the number of falls and hind-paw slips), suggesting that this test may be used for combined profiling of anxiety, motor-vestibular anomalies and anxiety-induced motor incoordination in rats." | 1.33 | Behavioural characterization in rats using the elevated alley Suok test. ( Kalueff, AV; Minasyan, A; Tuohimaa, P, 2005) |
| "Acetone has been shown to suppress experimental seizures." | 1.32 | Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. ( Burnham, WM; Cortez, MA; Likhodii, SS; Murphy, P; Serbanescu, I; Snead, OC, 2003) |
| " The pharmacokinetics of the active compounds was studied in dogs, which is a common animal model for a comparative crossover pharmacokinetic studies." | 1.30 | Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives. ( Bialer, M; Dagan, A; Sussan, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (35.71) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Verma, KK | 1 |
| Singh, UK | 1 |
| Jain, J | 1 |
| Koirala, B | 1 |
| Alele, PE | 1 |
| Devaud, LL | 1 |
| Gmiro, VE | 1 |
| Serdyuk, SE | 1 |
| Nitsinskaia, LE | 1 |
| Ekimova, IV | 1 |
| Guzhova, IV | 1 |
| Feĭzulaev, BA | 1 |
| Pastukhov, IuF | 1 |
| Baker, MT | 1 |
| Likhodii, SS | 1 |
| Serbanescu, I | 1 |
| Cortez, MA | 1 |
| Murphy, P | 1 |
| Snead, OC | 1 |
| Burnham, WM | 1 |
| DAVIS, MA | 1 |
| WINTHROP, SO | 1 |
| THOMAS, RA | 1 |
| HERR, F | 1 |
| CHAREST, MP | 1 |
| GAUDRY, R | 1 |
| Chiu, CS | 1 |
| Brickley, S | 1 |
| Jensen, K | 1 |
| Southwell, A | 1 |
| Mckinney, S | 1 |
| Cull-Candy, S | 1 |
| Mody, I | 1 |
| Lester, HA | 1 |
| Kalueff, AV | 1 |
| Minasyan, A | 1 |
| Tuohimaa, P | 1 |
| Manna, S | 1 |
| Bhattacharyya, D | 1 |
| Mandal, TK | 1 |
| Dey, S | 1 |
| Potschka, H | 1 |
| Pekcec, A | 1 |
| Weinhold, B | 1 |
| Gerardy-Schahn, R | 1 |
| Finn, DA | 2 |
| Roberts, AJ | 1 |
| Lotrich, F | 1 |
| Gallaher, EJ | 2 |
| Sussan, S | 1 |
| Dagan, A | 1 |
| Bialer, M | 1 |
| Borowicz, KK | 1 |
| Luszczki, J | 1 |
| Szadkowski, M | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Crabbe, JC | 1 |
| Vanover, KE | 1 |
| Hogenkamp, DJ | 1 |
| Lan, NC | 1 |
| Gee, KW | 1 |
| Carter, RB | 1 |
| Watson, WP | 1 |
| Little, HJ | 1 |
| Desmedt, LK | 1 |
| Niemegeers, CJ | 1 |
| Lewi, PJ | 1 |
| Janssen, PA | 1 |
| Giusti, P | 1 |
| Guidetti, G | 1 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| Velísková, J | 1 |
| Velísek, L | 1 |
| Mares, P | 1 |
| Rokyta, R | 1 |
| Potier, MC | 1 |
| Prado de Carvalho, L | 1 |
| Venault, P | 1 |
| Chapouthier, G | 1 |
| Rossier, J | 1 |
| Waters, JA | 1 |
| Hollingsworth, EB | 1 |
| Daly, JW | 1 |
| Lewandowski, G | 1 |
| Creveling, CR | 1 |
| Shannon, HE | 1 |
| Katzman, NJ | 1 |
| Waring, WS | 1 |
| Whittle, BA | 1 |
| Lewis, JW | 1 |
| Myers, PL | 1 |
| Ormerod, JA | 1 |
| Smith, CF | 1 |
| Atkinson, ER | 1 |
| Russ, PL | 1 |
| Tucker, MA | 1 |
| Marcus, RJ | 1 |
| Winters, WD | 1 |
| Roberts, E | 1 |
| Simonsen, DG | 1 |
| Braude, MC | 1 |
| Monroe, RR | 1 |
28 other studies available for pentylenetetrazole and Ataxia
| Article | Year |
|---|---|
Screening of Some Novel 4, 5 Disubstituted 1, 2, 4-Triazole-3-thiones for Anticonvulsant Activity.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Ataxia; Convulsants; Drug Evaluation, Precli | 2020 |
Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Central Nervous System Depressants; Data Interpr | 2008 |
Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia.
Topics: Animals; Ataxia; Biguanides; Drug Synergism; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Male | 2008 |
[EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures].
Topics: Animals; Antioxidants; Ataxia; Behavior, Animal; Corpus Callosum; Excitatory Amino Acid Agonists; GA | 2010 |
The anticonvulsant effects of propofol and a propofol analog, 2,6-diisopropyl-4-(1-hydroxy-2,2,2-trifluoroethyl)phenol, in a 6 Hz partial seizure model.
Topics: Animals; Anticonvulsants; Ataxia; Disease Models, Animal; Dose-Response Relationship, Drug; Electric | 2011 |
Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet.
Topics: Acetone; Amygdala; Animals; Anticonvulsants; Ataxia; Brain Chemistry; Convulsants; Diabetes Mellitus | 2003 |
ANTICONVULSANTS. I. DIBENZO(A,D)CYCLOHEPTADIENE-5-CARBOXAMIDE AND RELATED COMPOUNDS.
Topics: Amides; Anticonvulsants; Ataxia; Chemistry, Pharmaceutical; Mice; Pentylenetetrazole; Pharmacology; | 1964 |
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.
Topics: Animals; Anxiety; Ataxia; Behavior, Animal; Benzodiazepines; Body Temperature; Body Weight; Cerebell | 2005 |
Behavioural characterization in rats using the elevated alley Suok test.
Topics: Animals; Anxiety; Ataxia; Behavioral Research; Disease Models, Animal; Exploratory Behavior; Male; M | 2005 |
Neuropharmacological effects of deltamethrin in rats.
Topics: Animals; Ataxia; Brain; Female; gamma-Aminobutyric Acid; Insecticides; Male; Molecular Structure; Ni | 2006 |
Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX.
Topics: Analysis of Variance; Animals; Ataxia; Behavior, Animal; Disease Models, Animal; Excitatory Amino Ac | 2008 |
Genetic differences in behavioral sensitivity to a neuroactive steroid.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Ataxia; Avoidance Learning; Dose-Response Relationshi | 1997 |
Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives.
Topics: Animals; Anticonvulsants; Ataxia; Chromatography, High Pressure Liquid; Convulsants; Cross-Over Stud | 1999 |
Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Avoidance Learning; Benzodiazepines; Clonazepam; Drug Sy | 1999 |
Differential change in neuroactive steroid sensitivity during ethanol withdrawal.
Topics: Administration, Inhalation; Alcohol Withdrawal Seizures; Animals; Anticonvulsants; Anxiety; Ataxia; | 2000 |
Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Ataxia; Behavior, Animal; Convulsants; Discrimination | 2001 |
Selectivity of the protective effects of dihydropyridine calcium channel antagonists against the ethanol withdrawal syndrome.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Bicuculline; Body Temperature; Calcium Channel B | 2002 |
Antagonism of maximal metrazol seizures in rats and its relevance to an experimental classification of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Ataxia; Drug Evaluation, Preclinical; Female; Pentylenetetrazole; Posture; | 1976 |
The preferential antagonism of pentylenetetrazole proconflict responses differentiates a class of anxiolytic benzodiazepines with potential antipanic action.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Ataxia; Behavior, Animal; Conflict, Psychological; | 1991 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inb | 1990 |
Demonstration of the partial agonist profiles of Ro 16-6028 and Ro 17-1812 in mice in vivo.
Topics: Animals; Anticonvulsants; Ataxia; Benzodiazepinones; Brain; Conflict, Psychological; Diazepam; Male; | 1988 |
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.
Topics: Amino Alcohols; Animals; Anticonvulsants; Ataxia; Bridged Bicyclo Compounds; Bridged Bicyclo Compoun | 1986 |
CGS 8216: agonist and diazepam-antagonist effects in rodents.
Topics: Animals; Ataxia; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fl | 1986 |
Basic dihydromorphanthridinones with anticonvulsant activity.
Topics: Animals; Anticonvulsants; Ataxia; Dibenzazepines; Electroshock; Ethanol; Female; Hexobarbital; Male; | 1969 |
Chemistry and biological activity of N-substituted hydroxylamines.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Ataxia; Barbiturates; Behavior, Animal; Blood Pre | 1974 |
Neuropharmacological profile of 1-azaphenothiazine-10-thiolcarboxylates.
Topics: Adrenal Glands; Animals; Antihypertensive Agents; Ataxia; Cats; Depression, Chemical; Dogs; Drug Int | 1971 |
Neuropharmacological studies of imidazole-4-acetic acid actions in the mouse and rat.
Topics: Acetates; Animals; Ataxia; Behavior; Caffeine; Catalepsy; Central Nervous System; Drug Interactions; | 1971 |
Effects of dimethyl sulfoxide and alphaglucochloralose on pentylenetetrazol convulsive thresholds in mice.
Topics: Animals; Anticonvulsants; Ataxia; Central Nervous System; Chloralose; Dimethyl Sulfoxide; Drug Syner | 1967 |