pentylenetetrazole has been researched along with Astrocytosis in 8 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Taken together, although the seizure threshold is reduced in naive Spry2/4(+/-) mice, neurodegeneration and GCD is mitigated following KA induced hippocampal lesions, identifying Spry proteins as possible pharmacological targets in brain injuries resulting in neurodegeneration." | 5.43 | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. ( Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L, 2016) |
| "The CD₅₀ values for clonic and tonic seizures after oral administration were 0." | 5.38 | Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. ( Banks, CN; Bruun, DA; Dhir, A; Hammock, BD; Inceoglu, B; Lein, PJ; McCoy, MR; Rogawski, MA; Sanborn, JR; Zolkowska, D, 2012) |
| "Taken together, although the seizure threshold is reduced in naive Spry2/4(+/-) mice, neurodegeneration and GCD is mitigated following KA induced hippocampal lesions, identifying Spry proteins as possible pharmacological targets in brain injuries resulting in neurodegeneration." | 1.43 | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. ( Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L, 2016) |
| "The CD₅₀ values for clonic and tonic seizures after oral administration were 0." | 1.38 | Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. ( Banks, CN; Bruun, DA; Dhir, A; Hammock, BD; Inceoglu, B; Lein, PJ; McCoy, MR; Rogawski, MA; Sanborn, JR; Zolkowska, D, 2012) |
| "Ketogenic diets have been used to treat seizure disorders of children resistant to conventional anti-epileptic drug treatment." | 1.32 | Ketogenic diet fed rats have low levels of S100B in cerebrospinal fluid. ( Gonçalves, CA; Gonçalves, D; Leite, M; Mendez, A; Oliveira, DL; Perry, ML; Pires, C; Portela, LV; Ribeiro, L; Tramontina, F; Wofchuk, ST; Ziegler, DR, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ueno, H | 1 |
| Suemitsu, S | 1 |
| Murakami, S | 1 |
| Kitamura, N | 1 |
| Wani, K | 1 |
| Takahashi, Y | 1 |
| Matsumoto, Y | 1 |
| Okamoto, M | 1 |
| Ishihara, T | 1 |
| Sinha, P | 1 |
| Verma, B | 1 |
| Ganesh, S | 1 |
| Zhu, X | 1 |
| Dong, J | 1 |
| Shen, K | 1 |
| Bai, Y | 1 |
| Zhang, Y | 1 |
| Lv, X | 1 |
| Chao, J | 1 |
| Yao, H | 1 |
| Thongrong, S | 1 |
| Hausott, B | 1 |
| Marvaldi, L | 1 |
| Agostinho, AS | 1 |
| Zangrandi, L | 1 |
| Burtscher, J | 1 |
| Fogli, B | 1 |
| Schwarzer, C | 1 |
| Klimaschewski, L | 1 |
| Zolkowska, D | 1 |
| Banks, CN | 1 |
| Dhir, A | 1 |
| Inceoglu, B | 1 |
| Sanborn, JR | 1 |
| McCoy, MR | 1 |
| Bruun, DA | 1 |
| Hammock, BD | 1 |
| Lein, PJ | 1 |
| Rogawski, MA | 1 |
| Ziegler, DR | 1 |
| Oliveira, DL | 1 |
| Pires, C | 1 |
| Ribeiro, L | 1 |
| Leite, M | 1 |
| Mendez, A | 1 |
| Gonçalves, D | 1 |
| Tramontina, F | 1 |
| Portela, LV | 1 |
| Wofchuk, ST | 1 |
| Perry, ML | 1 |
| Gonçalves, CA | 1 |
| Ganor, Y | 1 |
| Gottlieb, M | 1 |
| Eilam, R | 1 |
| Otmy, H | 1 |
| Teichberg, VI | 1 |
| Levite, M | 1 |
| Meldrum, BS | 1 |
| Papy, JJ | 1 |
| Toure, MF | 1 |
| Brierley, JB | 1 |
8 other studies available for pentylenetetrazole and Astrocytosis
| Article | Year |
|---|---|
Pentylenetetrazol kindling induces cortical astrocytosis and increased expression of extracellular matrix molecules in mice.
Topics: Animals; Astrocytes; Cerebral Cortex; Extracellular Matrix; Gliosis; Hippocampus; Kindling, Neurolog | 2020 |
Trehalose Ameliorates Seizure Susceptibility in Lafora Disease Mouse Models by Suppressing Neuroinflammation and Endoplasmic Reticulum Stress.
Topics: Animals; Autophagy; Brain; Calcium-Binding Proteins; Disease Models, Animal; Disease Susceptibility; | 2021 |
NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Epilepsy; Excitatory Amino Acid | 2015 |
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Survival; Disease Models, Animal; Excitatory Ami | 2016 |
Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.
Topics: Animals; Astrocytes; Bridged-Ring Compounds; Calcium-Binding Proteins; Cerebral Cortex; Convulsants; | 2012 |
Ketogenic diet fed rats have low levels of S100B in cerebrospinal fluid.
Topics: Animals; Astrocytes; Biomarkers; Brain; Convulsants; Disease Models, Animal; Down-Regulation; Epilep | 2004 |
Immunization with the glutamate receptor-derived peptide GluR3B induces neuronal death and reactive gliosis, but confers partial protection from pentylenetetrazole-induced seizures.
Topics: Animals; Autoantibodies; Brain; Cell Count; Cell Death; Doublecortin Domain Proteins; Female; Gene P | 2005 |
Four models for studying cerebral lesions secondary to epileptic seizures.
Topics: Animals; Astrocytes; Bicuculline; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperatur | 1975 |