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pentylenetetrazole and Arrhythmias, Cardiac

pentylenetetrazole has been researched along with Arrhythmias, Cardiac in 20 studies

Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.

Research Excerpts

ExcerptRelevanceReference
"Cardiac arrhythmias are a proposed cause for some cases of SUDEP, yet the susceptibility and potential mechanism of arrhythmogenesis in Dravet syndrome remain unknown."1.39Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome. ( Auerbach, DS; Clawson, BC; Isom, LL; Jones, J; Lenk, GM; Meisler, MH; Offord, J; Ogiwara, I; Parent, JM; Yamakawa, K, 2013)
"Autonomic dysfunction, including arrhythmias, has been shown to be associated with epileptogenic activity."1.27The role of enkephalins in the production of epileptogenic activity and autonomic dysfunction: origin of arrhythmia and sudden death in the epileptic patient? ( Kraras, CM; Lathers, CM; Tumer, N, 1987)
"Phenobarbital pretreatment depressed heart rate, blood pressure and postganglionic cardiac sympathetic neural discharge."1.27Effect of phenobarbital pretreatment on cardiac neural discharge and pentylenetetrazol-induced epileptogenic activity in the cat. ( Carnel, SB; Lathers, CM; Schraeder, PL, 1985)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199017 (85.00)18.7374
1990's0 (0.00)18.2507
2000's2 (10.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Auerbach, DS1
Jones, J1
Clawson, BC1
Offord, J1
Lenk, GM1
Ogiwara, I1
Yamakawa, K1
Meisler, MH1
Parent, JM1
Isom, LL1
Sahin, D1
Ilbay, G1
Imal, M1
Bozdogan, O1
Ates, N1
Taha, AY1
Ciobanu, FA1
Saxena, A1
McIntyre Burnham, W1
BIRCHER, RP4
KANAI, T1
WANG, SC4
FERRISS, GS1
HACKETT, ER1
TANG, RZ1
SHAO, BR1
XEI, RR1
CHAI, CY2
Suter, LE1
Lathers, CM7
Schraeder, PL5
Carnel, SB2
Weiner, FL1
Kraras, CM1
Tumer, N1
Bhargava, KP1
Ferrini, R1
Miragoli, G1
Croce, G1
Tymiński, W1
Czestochowska, E1
Szlabowicz, JW1
Makabe, T1
Rozear, M1
Tseng, DT1

Reviews

2 reviews available for pentylenetetrazole and Arrhythmias, Cardiac

ArticleYear
Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy.
    Epilepsy & behavior : E&B, 2009, Volume: 14, Issue:1

    Topics: Animals; Anticonvulsants; Arrhythmias, Cardiac; Cardiotonic Agents; Convulsants; Death, Sudden, Card

2009
Modulation of presynaptic gamma aminobutyric acid release by prostaglandin E2: explanation for epileptogenic activity and dysfunction in autonomic cardiac neural discharge leading to arrhythmias?
    Medical hypotheses, 1984, Volume: 15, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Cats; Dinoprostone; Epilepsy; gamma-Aminobu

1984

Other Studies

18 other studies available for pentylenetetrazole and Arrhythmias, Cardiac

ArticleYear
Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiac Electrophysiology; Death, Sudden, Cardiac;

2013
Vagus nerve stimulation suppresses generalized seizure activity and seizure-triggered postictal cardiac rhythm changes in rats.
    Physiological research, 2009, Volume: 58, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Electrocardiography; Electroe

2009
Mechanism of cardiac arrhythmias and blood pressure changes induced in dogs by pentylenetetrazol, picrotoxin, and deslanoside.
    The Journal of pharmacology and experimental therapeutics, 1963, Volume: 141

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Deslanoside; Dogs; Lanatosides; Pentylenetetrazole; P

1963
CARDIAC ARREST DURING INTRAVENOUS METRAZOL ADMINISTRATION. REPORT OF A CASE DURING EEG ACTIVATION PROCEDURE.
    Electroencephalography and clinical neurophysiology, 1963, Volume: 15

    Topics: Arrhythmia, Sinus; Arrhythmias, Cardiac; Bradycardia; Electrocardiography; Electroencephalography; H

1963
[SOME PHARMACOLOGICAL ACTIONS OF F30066].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1964, Volume: 11

    Topics: Arrhythmias, Cardiac; Body Temperature; Central Nervous System; Gastrointestinal Tract; Guinea Pigs;

1964
EFFECTS OF HEXAMETHONIUM AND TETRAETHYLAMMONIUM ON CARDIAC ARRHYTHMIAS PRODUCED BY PENTYLENETETRAZOL, PICROTOXIN AND DESLANOSIDE IN DOGS.
    The Journal of pharmacology and experimental therapeutics, 1965, Volume: 149

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Central Nervous System; Deslanoside; Dogs;

1965
Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: the effect of phenobarbital in the cat.
    Life sciences, 1984, May-14, Volume: 34, Issue:20

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Disease Models, Anima

1984
Cardiac neural discharge and epileptogenic activity in the cat: an animal model for unexplained death.
    Life sciences, 1983, Mar-21, Volume: 32, Issue:12

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Death, Sudden; Electr

1983
Autonomic dysfunction in epilepsy: characterization of autonomic cardiac neural discharge associated with pentylenetetrazol-induced epileptogenic activity.
    Epilepsia, 1982, Volume: 23, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Cats; Heart; Parasympathetic Nervo

1982
Synchronization of cardiac autonomic neural discharge with epileptogenic activity: the lockstep phenomenon.
    Electroencephalography and clinical neurophysiology, 1987, Volume: 67, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Cats; Dysautonomia, Familial; Electroencephalography; Epilepsy; Heart

1987
The role of enkephalins in the production of epileptogenic activity and autonomic dysfunction: origin of arrhythmia and sudden death in the epileptic patient?
    Medical hypotheses, 1987, Volume: 23, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Death, Sudden; Enkephalins;

1987
Effect of phenobarbital pretreatment on cardiac neural discharge and pentylenetetrazol-induced epileptogenic activity in the cat.
    Pharmacology, 1985, Volume: 30, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electrocardio

1985
On the importance of a central beta-adrenoceptor site in the antiarrhythmic activity of beta-blockers.
    Indian heart journal, 1972, Volume: 24

    Topics: Aconitum; Adrenal Glands; Adrenergic beta-Antagonists; Alprenolol; Animals; Arrhythmias, Cardiac; Ca

1972
Pharmacological actions of 1-(o-methoxyphenoxy)3-isopropylamino-2-propanol hydrochloride (S-D-1601), a new beta-blocking agent.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:8

    Topics: Adrenergic beta-Antagonists; Amphetamine; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Antic

1970
Activation of fibrinolysis during electroconvulsive treatment.
    Polish medical journal, 1971, Volume: 10, Issue:5

    Topics: Anesthesia, General; Arrhythmias, Cardiac; Cold Temperature; Convulsive Therapy; Electric Countersho

1971
[Influence of pentetrazol (PTZ), dimorpholamine (DMP) and trans-pi-oxocamphor (t-pi-oc) on the ventricular pacemaker of guinea pigs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1969, May-20, Volume: 65, Issue:3

    Topics: Amides; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Bradycardia; Camphor; Electrocardiog

1969
Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside.
    International journal of neuropharmacology, 1968, Volume: 7, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Atropa belladonna; Bradycardia; Carotid Artery Thrombosis; Central Ne

1968
Effects of synthetic oxytocin on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside.
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 172, Issue:1

    Topics: Arrhythmias, Cardiac; Cardiovascular System; Electrocardiography; Heart Ventricles; Injections, Intr

1968
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