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pentylenetetrazole and Apoplexy

pentylenetetrazole has been researched along with Apoplexy in 7 studies

Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Research Excerpts

ExcerptRelevanceReference
" In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects."8.12Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022)
"The effects of the halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine (3,5-DBr-D: -Tyr) were studied in rat models of stroke and epileptic seizures caused by middle cerebral artery occlusion (MCAo) through respective intracerebral injection of endothelin-1 (ET-1) and intraperitoneal (i."7.77Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. ( Cao, W; Glushakov, A; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2011)
" 3,5-DBr-L-Phe was also given as a single bolus prior to pentylenetetrazole (PTZ) injection to induce seizures or prior to the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) to cause disruption of prepulse inhibition (PPI) of startle (sensorimotor gating deficit)."7.75Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. ( Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2009)
" In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects."4.12Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022)
" We demonstrated that right common carotid ligation decreases the threshold for clonic seizures induced by pentylenetetrazole (PTZ), a GABA antagonist."3.81Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems. ( Abdolghaffari, AH; Aleyasin, AR; Azizi, Y; Chabouk, L; Dehpour, AR; Gooshe, M; Hassanzadeh, GR; Partoazar, A; Payandemehr, B; Tofigh, S, 2015)
"The effects of the halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine (3,5-DBr-D: -Tyr) were studied in rat models of stroke and epileptic seizures caused by middle cerebral artery occlusion (MCAo) through respective intracerebral injection of endothelin-1 (ET-1) and intraperitoneal (i."3.77Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures. ( Cao, W; Glushakov, A; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2011)
" 3,5-DBr-L-Phe was also given as a single bolus prior to pentylenetetrazole (PTZ) injection to induce seizures or prior to the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) to cause disruption of prepulse inhibition (PPI) of startle (sensorimotor gating deficit)."3.75Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. ( Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2009)
"Perinatal stroke is a common cerebrovascular disorder affecting 1 in every 4000 births; typically associated with epilepsy."1.39Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7. ( Brima, T; Mareš, P; Otáhal, J, 2013)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Shayan, M1
Eslami, F1
Amanlou, A1
Solaimanian, S1
Rahimi, N1
Rashidian, A1
Ejtemaei-Mehr, S1
Ghasemi, M1
Dehpour, AR2
Brima, T1
Otáhal, J1
Mareš, P1
Nuñez-Figueredo, Y1
Ramírez-Sánchez, J1
Delgado-Hernández, R1
Porto-Verdecia, M1
Ochoa-Rodríguez, E1
Verdecia-Reyes, Y1
Marin-Prida, J1
González-Durruthy, M1
Uyemura, SA1
Rodrigues, FP1
Curti, C1
Souza, DO1
Pardo-Andreu, GL1
Gooshe, M1
Abdolghaffari, AH1
Aleyasin, AR1
Chabouk, L1
Tofigh, S1
Hassanzadeh, GR1
Payandemehr, B1
Partoazar, A1
Azizi, Y1
Cao, W2
Shah, HP2
Glushakov, AV1
Mecca, AP2
Shi, P2
Sumners, C2
Seubert, CN2
Martynyuk, AE2
Glushakov, A1
Reed, RR1
Ciesel, C1
Owens, G1

Other Studies

7 other studies available for pentylenetetrazole and Apoplexy

ArticleYear
Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K
    Toxicology and applied pharmacology, 2022, 11-01, Volume: 454

    Topics: Adenosine Triphosphate; Animals; Anticonvulsants; bcl-2-Associated X Protein; Benzamides; Disease Mo

2022
Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7.
    Brain research, 2013, Apr-24, Volume: 1507

    Topics: Animals; Brain; Brain Ischemia; Convulsants; Disease Models, Animal; Electroencephalography; Epileps

2013
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
    European journal of pharmacology, 2014, Mar-05, Volume: 726

    Topics: Animals; Benzodiazepines; Brain Ischemia; Calcium; Cell Death; Cerebellum; Cytochromes c; Dihydropyr

2014
Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems.
    European journal of pharmacology, 2015, Jan-05, Volume: 746

    Topics: Analgesics, Opioid; Animals; Brain Ischemia; Cell Hypoxia; Drug Synergism; GABA Antagonists; Male; M

2015
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
    British journal of pharmacology, 2009, Volume: 158, Issue:8

    Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Endothelin-1; Gait Disorders, Neurologic; Glut

2009
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
    Amino acids, 2011, Volume: 40, Issue:4

    Topics: Animals; Blood Pressure; Brain; Caspase 3; Disease Models, Animal; Endothelin-1; Epilepsy; Heart Rat

2011
Induced seizures as therapy of experimental strokes in dogs.
    Journal of neurosurgery, 1971, Volume: 34, Issue:2 Pt 1

    Topics: Animals; Blood Pressure; Brain; Carotid Stenosis; Convulsants; Disease Models, Animal; Dogs; Electri

1971
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