pentylenetetrazole has been researched along with Anxiety in 128 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of rapamycin on anxiety and depression caused by pentylenetetrazole (PTZ) in the rat and possible underlying mechanisms were evaluated." | 8.02 | Rapamycin attenuates depression and anxiety-like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats. ( Aghaie, F; Hosseini, A; Moradifar, F, 2021) |
| "We found that pterostilbene at a dose of 200 mg/kg considerably reduced seizure activity but did not influence the locomotor activity and depression- and anxiety-like behavior in the PTZ-kindled mice." | 8.02 | Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies. ( Nalepa, I; Nieoczym, D; Pieróg, M; Przejczowska-Pomierny, K; Socała, K; Szafarz, M; Wlaź, P; Wyska, E; Zelek-Molik, A, 2021) |
| "The aim of the present study was to investigate the effect of rutin administration (100 mg/kg/day) to pentylenetetrazol (PTZ)-treated Balb-c mice (60 mg/kg/day), with respect to anxiety-like behavior using both open-field and elevated plus-maze (EPM) tests, and acetylcholinesterase (AChE) activity in salt-soluble (SS) fraction and detergent-soluble (DS) fraction of the cerebral cortex, hippocampus, striatum, midbrain, and diencephalon." | 7.96 | Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice. ( Anesti, M; Atsopardi, K; Lamari, FN; Margarity, M; Panagopoulos, NT; Stavropoulou, N, 2020) |
| "Pentylenetetrazole (PTZ), γ-aminobutyrate (GABA) antagonist, is a convulsant drug, known to induce anxiety and seizures in zebrafish." | 7.83 | Anxiety-related behavioral responses of pentylenetetrazole-treated zebrafish larvae to light-dark transitions. ( Guo, N; Ji, Y; Li, Q; Lin, J; Liu, X; Peng, X; Yang, X; Zhang, Y; Zhu, Y, 2016) |
| "This study investigated the effects of a benzodiazepine partial agonist, abecarnil, and a full agonist, alprazolam, on ethanol withdrawal-induced anxiety-like behaviors in rats." | 7.70 | Abecarnil and alprazolam reverse anxiety-like behaviors induced by ethanol withdrawal. ( Gatch, MB; Jung, ME; Lal, H; Wallis, CJ, 2000) |
| " The compounds chosen are likely to produce anxiety by activity at different sites in the central nervous system: yohimbine, by blocking the alpha 2-adrenoceptor; FG 7142, by action at the beta-carboline site on the GABA-benzodiazepine receptor complex and pentylenetetrazole, by acting at the picrotoxinin site on this complex." | 7.67 | Chronic treatment with imipramine does not reverse the effects of 3 anxiogenic compounds in a test of anxiety in the rat. ( File, SE; Johnston, AL, 1987) |
| "Trimethadione was compared with chlordiazepoxide for anti-anxiety activity in two behavioral tests known to predict the anxiolytic action of drugs." | 7.66 | Comparison of the actions of trimethadione and chlordiazepoxide in animal models of anxiety and benzodiazepine receptor binding. ( Bennett, DA; Brugger, S; Dutta, P; Fielding, S; Geyer, H; Lal, H, 1982) |
| "In various organisms, stress is a seizure-related comorbidity." | 5.62 | Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish. ( Canzian, J; Franscescon, F; Müller, TE; Rosa, LV; Rosemberg, DB; Souza, TP; Stefanello, FV, 2021) |
| "The intensity of convulsion was scored according to a seven-point scale ranging from stage 0-7." | 5.62 | Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice. ( Abiola, AL; Akhigbemen, AM; Chinazamoku, O; Igbe, I; Ogundepo, GE; Okwuofu, EO; Ozolua, RI, 2021) |
| "We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats." | 5.48 | Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018) |
| "Levetiracetam (LEV) is a unique, effective, relatively safe antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 5.42 | Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats. ( Abdel-Wahab, BA; Habeeb, SM; Khateeb, MM; Shaikh, IA, 2015) |
| "BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific." | 5.39 | Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013) |
| "EDA has been shown to reduce seizures caused by systemic injection of proconvulsants in an animal model of generalized tonic-clonic seizures." | 5.38 | Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety. ( Addae, JI; Cruickshank, R; Stone, TW; Walkins, K, 2012) |
| " Both acute and chronic administration of quercetin (25 or 50 mg/kg, p." | 5.33 | Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions. ( Joshi, D; Kulkarni, SK; Naidu, PS; Singh, A, 2005) |
| " Some antiseizure drugs (ASDs) have been shown to produce discrepant results in larvae and adults zebrafish, therefore, their anticonvulsant efficacy in subsequent stages of the pentylenetetrazole (PTZ)-induced seizures should be more precisely characterized." | 4.02 | Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish. ( Doboszewska, U; Guz, L; Pieróg, M; Poleszak, E; Serefko, A; Socała, K; Szopa, A; Wlaź, P; Wyska, E, 2021) |
| "The effects of rapamycin on anxiety and depression caused by pentylenetetrazole (PTZ) in the rat and possible underlying mechanisms were evaluated." | 4.02 | Rapamycin attenuates depression and anxiety-like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats. ( Aghaie, F; Hosseini, A; Moradifar, F, 2021) |
| " In this study, the pentylenetetrazole seizure test (PTZ) was performed to assess the effectiveness of four new ASDs: lamotrigine (LTG), topiramate (TPM), felbamate (FBM), and levetiracetam (LEV) in the subsequent stages of seizures in adult fish." | 4.02 | Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish. ( Doboszewska, U; Guz, L; Pieróg, M; Poleszak, E; Serefko, A; Socała, K; Szopa, A; Wlaź, P; Wyska, E, 2021) |
| "We found that pterostilbene at a dose of 200 mg/kg considerably reduced seizure activity but did not influence the locomotor activity and depression- and anxiety-like behavior in the PTZ-kindled mice." | 4.02 | Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies. ( Nalepa, I; Nieoczym, D; Pieróg, M; Przejczowska-Pomierny, K; Socała, K; Szafarz, M; Wlaź, P; Wyska, E; Zelek-Molik, A, 2021) |
| "The aim of the present study was to investigate the effect of rutin administration (100 mg/kg/day) to pentylenetetrazol (PTZ)-treated Balb-c mice (60 mg/kg/day), with respect to anxiety-like behavior using both open-field and elevated plus-maze (EPM) tests, and acetylcholinesterase (AChE) activity in salt-soluble (SS) fraction and detergent-soluble (DS) fraction of the cerebral cortex, hippocampus, striatum, midbrain, and diencephalon." | 3.96 | Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice. ( Anesti, M; Atsopardi, K; Lamari, FN; Margarity, M; Panagopoulos, NT; Stavropoulou, N, 2020) |
| "Pentylenetetrazole (PTZ), γ-aminobutyrate (GABA) antagonist, is a convulsant drug, known to induce anxiety and seizures in zebrafish." | 3.83 | Anxiety-related behavioral responses of pentylenetetrazole-treated zebrafish larvae to light-dark transitions. ( Guo, N; Ji, Y; Li, Q; Lin, J; Liu, X; Peng, X; Yang, X; Zhang, Y; Zhu, Y, 2016) |
| "The neuropharmacological effects of the extract were evaluated using a variety of models, such as the elevated plus maze (EPM), the forced swimming test (FST), the pentobarbital potentiation test (PTBt), pentylenetetrazole-induced seizures test (PTZt), and the open field test (OFT)." | 3.79 | Neuropharmacological in vivo effects and phytochemical profile of the extract from the aerial parts of Heteropterys brachiata (L.) DC. (Malpighiaceae). ( Aguilar-Rojas, A; González-Cortazar, M; Herrera-Ruiz, M; Huerta-Reyes, M; León, E; Reyes-Chilpa, R; Tortoriello, J; Zamilpa, A, 2013) |
| "6 microg/microl) effectively prevented seizures induced by the unilateral GABAergic blockade of Area tempestas (bicuculline, 0." | 3.73 | Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae). ( Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR, 2006) |
| " Increasing current electroshock test (ICES), pentylenetetrazole (PTZ)-induced seizures, forced swim test (FST), passive avoidance response (PAR), spontaneous alternation behaviour (SAB) and elevated plus maze (EPM) were used for studying the acute effects of sparfloxacin while ICES, grip strength test (GST) and urinary hydroxyproline estimations were done for studying its chronic effects." | 3.73 | Effects of sparfloxacin on CNS functions and urinary hydroxyproline in mice. ( Bharal, N; Pillai, KK; Vohora, D, 2006) |
| " A crude extract was given systemically and its effects were tested on pentylenetetrazole (PTZ)-induced seizures, sodium pentobarbital-induced hypnosis, exploratory activity, anxiety and nociception." | 3.73 | Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice. ( Carrera, D; Cedillo-Portugal, E; Gonzalez-Trujano, ME; Navarrete, A; Ventura-Martinez, R, 2006) |
| "Benzodiazepines are used to treat the anxiety associated with cocaine withdrawal, as well as cocaine-induced seizures." | 3.70 | Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression. ( Lilly, SM; Tietz, EI, 2000) |
| "This study investigated the effects of a benzodiazepine partial agonist, abecarnil, and a full agonist, alprazolam, on ethanol withdrawal-induced anxiety-like behaviors in rats." | 3.70 | Abecarnil and alprazolam reverse anxiety-like behaviors induced by ethanol withdrawal. ( Gatch, MB; Jung, ME; Lal, H; Wallis, CJ, 2000) |
| "), an endogenous neuroactive metabolite of tryptophan, attenuated the most stable effect of anxiogens in this model of anxiety--a decrease in the rate of leanings-out of the dark compartment --induced by caffeine, pentylenetetrazole and yohimbine, but not by beta-phenylethylamine (PEA)." | 3.70 | Antagonism of kynurenic acid to anxiogens in mice. ( Lapin, IP, 1998) |
| " We now report that pharmacological conditioning of pigs with a drug, pentylenetetrazole, known to induce anxiety in man, permits investigation of the presence or absence of this psychological state during exposure to a variety of environmental stimuli encountered during normal husbandry." | 3.69 | Evaluation of animal welfare by the self-expression of an anxiety state. ( Carey, MP; Fry, JP, 1995) |
| "0 mg/kg pentylenetetrazole, PTZ) would also reduce nociception; c) if exposure to the EPM would alter visceral pain, as measured by the abdominal contortion test." | 3.68 | Anxiety-induced antinociception in the mouse. ( Conceição, IM; Frussa-Filho, R; Maiolini Júnior, M; Mattia, N; Santos, BR; Smaili, S; Vital, MA, 1992) |
| "The effects of the anxiogenic agents FG7142, caffeine, pentylenetetrazole, and amphetamine were assessed in two anxiety situations in the marmoset, first in an "anxiogenic" test based on the animal's response to a human observer standing in front of the home cage and second in a low-anxiety situation where animals behaviour was videotaped in the absence of the observer." | 3.68 | Behavioural effects of anxiogenic agents in the common marmoset. ( Carey, GJ; Costall, B; Domeney, AM; Jones, DN; Naylor, RJ, 1992) |
| " The compounds chosen are likely to produce anxiety by activity at different sites in the central nervous system: yohimbine, by blocking the alpha 2-adrenoceptor; FG 7142, by action at the beta-carboline site on the GABA-benzodiazepine receptor complex and pentylenetetrazole, by acting at the picrotoxinin site on this complex." | 3.67 | Chronic treatment with imipramine does not reverse the effects of 3 anxiogenic compounds in a test of anxiety in the rat. ( File, SE; Johnston, AL, 1987) |
| " RO 15-3505 induced seizures in mice treated with a subconvulsant dose of pentylenetetrazole, the most efficient doses being 3 and 6 mg/kg." | 3.67 | The benzodiazepine receptor inverse agonists beta-CCM and RO 15-3505 both reverse the anxiolytic effects of ethanol in mice. ( Belzung, C; Misslin, R; Vogel, E, 1988) |
| "Trimethadione was compared with chlordiazepoxide for anti-anxiety activity in two behavioral tests known to predict the anxiolytic action of drugs." | 3.66 | Comparison of the actions of trimethadione and chlordiazepoxide in animal models of anxiety and benzodiazepine receptor binding. ( Bennett, DA; Brugger, S; Dutta, P; Fielding, S; Geyer, H; Lal, H, 1982) |
| " Further, these stimuli can be easily quantified through dose-response analysis." | 2.36 | Behavioral analogues of anxiety. Animal models. ( Emmett-Oglesby, MW; Lal, H, 1983) |
| "Meanwhile, it decreased the seizure severity and reduced seizure-caused anxious behavior in the PTZ-kindling mice, suggesting a significant antiepileptic activity and anxiolytic/anxiogenic potential." | 1.91 | Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway. ( He, X; Liu, Y; Xie, Y; Yang, Y; Yuan, X, 2023) |
| "In various organisms, stress is a seizure-related comorbidity." | 1.62 | Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish. ( Canzian, J; Franscescon, F; Müller, TE; Rosa, LV; Rosemberg, DB; Souza, TP; Stefanello, FV, 2021) |
| "Epilepsy is a chronic brain disease affecting millions of people worldwide." | 1.62 | Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy. ( Mosaferi, B; Najdi, N; Salari, AA; Zeraati, M, 2021) |
| "The intensity of convulsion was scored according to a seven-point scale ranging from stage 0-7." | 1.62 | Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice. ( Abiola, AL; Akhigbemen, AM; Chinazamoku, O; Igbe, I; Ogundepo, GE; Okwuofu, EO; Ozolua, RI, 2021) |
| "In the pentylenetetrazol (PTZ) seizure-susceptibility test, dKO mice had a shorter latency to the first epileptiform spike (p = 0." | 1.51 | Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility. ( Bolkvadze, T; Ekolle Ndode-Ekane, X; Koivisto, H; Kyyriäinen, J; Lipponen, A; Pérez, LO; Pitkänen, A; Tanila, H, 2019) |
| "We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats." | 1.48 | Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018) |
| "Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes." | 1.46 | Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease. ( Sánchez, MP; Sánchez-Elexpuru, G; Serratosa, JM, 2017) |
| "Convulsive seizures are due to abnormal synchronous and repetitive neuronal discharges in the central nervous system (CNS)." | 1.46 | SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats. ( Asadi, S; Fereidoni, M; Kordi Jaz, E; Moghimi, A; Roohbakhsh, A; Shamsizadeh, A, 2017) |
| "Levetiracetam (LEV) is a unique, effective, relatively safe antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 1.42 | Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats. ( Abdel-Wahab, BA; Habeeb, SM; Khateeb, MM; Shaikh, IA, 2015) |
| "apodanthera showed dose-dependent antiseizure effects." | 1.42 | Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice. ( Ayissi, ER; Kandeda, AK; Kouemou, N; Moto, FC; Ngo Bum, E; Ngoupaye, GT; Njapdounke, JS; Nkantchoua, GC; Omam, JP; Pahaye, D; Pale, S; Taiwe, GS, 2015) |
| "Valerenic acid (VA) is a β2/3 subunit-specific modulator of γ-aminobutyric acid (GABA) type A (GABAA) receptors inducing anxiolysis." | 1.40 | Esters of valerenic acid as potential prodrugs. ( Haider, M; Hering, S; Hintersteiner, J; Jäger, W; Khom, S; Luger, D; Mihovilovic, MD; Reznicek, G; Schwarzer, C, 2014) |
| "Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together." | 1.39 | Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. ( Augustin, I; Begemann, M; Brose, N; Ehrenreich, H; Gurvich, A; Ju, A; Man, KN; Müller-Ribbe, K; Papiol, S; Ronnenberg, A; Shin, Y; Stepniak, B; Tantra, M; Wojcik, SM, 2013) |
| "BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific." | 1.39 | Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013) |
| "EDA has been shown to reduce seizures caused by systemic injection of proconvulsants in an animal model of generalized tonic-clonic seizures." | 1.38 | Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety. ( Addae, JI; Cruickshank, R; Stone, TW; Walkins, K, 2012) |
| " The results showed proconvulsant effect of gatifloxacin (50 mg/kg) in pentylenetetrazole-induced seizure test after both short- and long-term administration studies." | 1.35 | Anxiogenic and proconvulsant effect of gatifloxacin in mice. ( Bharal, N; Gupta, S; Khurana, S; Mediratta, PK; Sharma, KK, 2008) |
| "High anxiety also leads to higher motor incoordination (as assessed by the number of falls and hind-paw slips), suggesting that this test may be used for combined profiling of anxiety, motor-vestibular anomalies and anxiety-induced motor incoordination in rats." | 1.33 | Behavioural characterization in rats using the elevated alley Suok test. ( Kalueff, AV; Minasyan, A; Tuohimaa, P, 2005) |
| " Both acute and chronic administration of quercetin (25 or 50 mg/kg, p." | 1.33 | Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions. ( Joshi, D; Kulkarni, SK; Naidu, PS; Singh, A, 2005) |
| " Pharmacokinetic analysis of several compounds indicated excellent oral bioavailability and a reasonable half-life in rats." | 1.30 | Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. ( Belonga, KL; Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; Mickelson, JW; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; TenBrink, RE; VonVoigtlander, PF; Zhong, WZ, 1999) |
| ") was antagonized by the chronic administration of lorazepam as well as sodium valproate, a GABA agonist." | 1.28 | The anxiogenic-like effects of pentylenetetrazole in mice treated chronically with carbamazepine or valproate. ( de Angelis, L, 1992) |
| " In the pair-fed controls, or rats withdrawn from the smaller dosage of either ethanol or cocaine, the test dose of saline or cocaine did not elicit the PTZ-stimulus; only 30% of rats selected the PTZ-appropriate level at the highest dose of cocaine tested (10 mg/kg)." | 1.28 | Protracted withdrawal: sensitization of the anxiogenic response to cocaine in rats concurrently treated with ethanol. ( Lal, H; Prather, PL, 1992) |
| "Isatin has recently been identified in rat tissues and normal human urine where it constitutes the major part of the endogenous monoamine oxidase inhibitor, tribulin." | 1.28 | Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration. ( Clow, A; Davidson, J; Glover, V; Halket, JM; Milton, AS; Sandler, M; Watkins, PJ, 1989) |
| " Following redetermination of the PTZ and cocaine dose-response curves, chronic cocaine injections were terminated and spontaneous withdrawal was assessed by determining its substitution for the PTZ stimulus." | 1.27 | Anxiogenic properties of cocaine withdrawal. ( Lal, H; Wood, DM, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (22.66) | 18.7374 |
| 1990's | 31 (24.22) | 18.2507 |
| 2000's | 28 (21.88) | 29.6817 |
| 2010's | 28 (21.88) | 24.3611 |
| 2020's | 12 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, Y | 1 |
| Yang, Y | 1 |
| Yuan, X | 1 |
| Liu, Y | 1 |
| He, X | 1 |
| Canzian, J | 2 |
| Müller, TE | 2 |
| Franscescon, F | 2 |
| Michelotti, P | 1 |
| Fontana, BD | 1 |
| Costa, FV | 1 |
| Rosemberg, DB | 2 |
| Rico, JL | 1 |
| Bonuti, R | 1 |
| Morato, S | 1 |
| Anesti, M | 1 |
| Stavropoulou, N | 1 |
| Atsopardi, K | 1 |
| Lamari, FN | 1 |
| Panagopoulos, NT | 1 |
| Margarity, M | 1 |
| Jin, Y | 1 |
| Cai, S | 1 |
| Jiang, Y | 1 |
| Zhong, K | 1 |
| Wen, C | 1 |
| Ruan, Y | 1 |
| Chew, LA | 1 |
| Khanna, R | 1 |
| Xu, Z | 1 |
| Yu, J | 1 |
| Holanda, DKR | 1 |
| Wurlitzer, NJ | 1 |
| Dionisio, AP | 1 |
| Campos, AR | 1 |
| Moreira, RA | 1 |
| Sousa, PHM | 1 |
| Brito, ES | 1 |
| Ribeiro, PRV | 1 |
| Iunes, MF | 1 |
| Costa, AM | 1 |
| Rios, MY | 1 |
| Ortega, A | 1 |
| Domínguez, B | 1 |
| Déciga, M | 1 |
| Rosa, V | 1 |
| Nesci, V | 1 |
| Russo, E | 1 |
| Arcidiacono, B | 1 |
| Citraro, R | 1 |
| Tallarico, M | 1 |
| Constanti, A | 1 |
| Brunetti, A | 1 |
| De Sarro, G | 1 |
| Leo, A | 1 |
| Zeraati, M | 1 |
| Najdi, N | 1 |
| Mosaferi, B | 1 |
| Salari, AA | 1 |
| Stefanello, FV | 1 |
| Souza, TP | 1 |
| Rosa, LV | 1 |
| Pieróg, M | 3 |
| Socała, K | 3 |
| Doboszewska, U | 2 |
| Wyska, E | 3 |
| Guz, L | 2 |
| Szopa, A | 2 |
| Serefko, A | 2 |
| Poleszak, E | 2 |
| Wlaź, P | 3 |
| Okwuofu, EO | 1 |
| Ogundepo, GE | 1 |
| Akhigbemen, AM | 1 |
| Abiola, AL | 1 |
| Ozolua, RI | 1 |
| Igbe, I | 1 |
| Chinazamoku, O | 1 |
| Aghaie, F | 1 |
| Moradifar, F | 1 |
| Hosseini, A | 1 |
| Nieoczym, D | 1 |
| Zelek-Molik, A | 1 |
| Przejczowska-Pomierny, K | 1 |
| Szafarz, M | 1 |
| Nalepa, I | 1 |
| Dhamne, SC | 1 |
| Silverman, JL | 1 |
| Super, CE | 1 |
| Lammers, SHT | 1 |
| Hameed, MQ | 1 |
| Modi, ME | 1 |
| Copping, NA | 1 |
| Pride, MC | 1 |
| Smith, DG | 1 |
| Rotenberg, A | 1 |
| Crawley, JN | 1 |
| Sahin, M | 1 |
| Matovu, D | 1 |
| Alele, PE | 1 |
| Asadi, S | 2 |
| Roohbakhsh, A | 2 |
| Shamsizadeh, A | 2 |
| Fereidoni, M | 2 |
| Kordijaz, E | 1 |
| Moghimi, A | 2 |
| Kyyriäinen, J | 1 |
| Bolkvadze, T | 1 |
| Koivisto, H | 1 |
| Lipponen, A | 1 |
| Pérez, LO | 1 |
| Ekolle Ndode-Ekane, X | 1 |
| Tanila, H | 1 |
| Pitkänen, A | 1 |
| O'Connor, RM | 1 |
| Thakker, DR | 1 |
| Schmutz, M | 1 |
| van der Putten, H | 1 |
| Hoyer, D | 1 |
| Flor, PJ | 1 |
| Cryan, JF | 1 |
| Wojcik, SM | 1 |
| Tantra, M | 1 |
| Stepniak, B | 1 |
| Man, KN | 1 |
| Müller-Ribbe, K | 1 |
| Begemann, M | 1 |
| Ju, A | 1 |
| Papiol, S | 1 |
| Ronnenberg, A | 1 |
| Gurvich, A | 1 |
| Shin, Y | 1 |
| Augustin, I | 1 |
| Brose, N | 1 |
| Ehrenreich, H | 1 |
| Pagnussat, N | 1 |
| Piato, AL | 1 |
| Schaefer, IC | 1 |
| Blank, M | 1 |
| Tamborski, AR | 1 |
| Guerim, LD | 1 |
| Bonan, CD | 1 |
| Vianna, MR | 1 |
| Lara, DR | 1 |
| Hoeller, AA | 1 |
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3 reviews available for pentylenetetrazole and Anxiety
| Article | Year |
|---|---|
Behavioral analogues of anxiety. Animal models.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Conditioning, Psychological; Convulsants; Disease Mode | 1983 |
Differential pharmacological effects of benzodiazepine receptor inverse agonists.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Carbolines; Convulsants; Electroshock; Human | 1983 |
Molecular substrates of anxiety: clues from the heterogeneity of benzodiazepine receptors.
Topics: Aging; Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Chemical Phenomen | 1982 |
125 other studies available for pentylenetetrazole and Anxiety
| Article | Year |
|---|---|
Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway.
Topics: Acorus; Animals; Anticonvulsants; Anxiety; Epilepsy; gamma-Aminobutyric Acid; Inflammation; Mice; Ox | 2023 |
Modeling psychiatric comorbid symptoms of epileptic seizures in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Female; GABA Antagonists; Humans; Locomo | 2019 |
The elevated gradient of aversion: a new apparatus to study the rat behavior dimensions of anxiety, fear, and impulsivity.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Apomorphine; Behavior, Anim | 2019 |
Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice.
Topics: Acetylcholinesterase; Animals; Anxiety; Brain; Isoenzymes; Male; Maze Learning; Mice; Mice, Inbred B | 2020 |
Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
Topics: Animals; Anticonvulsants; Anxiety; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channe | 2019 |
Garlic passion fruit (Passiflora tenuifila Killip): Assessment of eventual acute toxicity, anxiolytic, sedative, and anticonvulsant effects using in vivo assays.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Dia | 2020 |
Glaucacetalin E and galphimidin B from Galphimia glauca and their anxiolytic activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Disease Models, Animal; Ex | 2020 |
Metabolic Alterations Predispose to Seizure Development in High-Fat Diet-Treated Mice: the Role of Metformin.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Blood Glucose; Body Composition; Depression; | 2020 |
Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Convulsants; Disease Models, Animal; Dise | 2021 |
Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish.
Topics: Animals; Anxiety; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Central Nervo | 2021 |
Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice.
Topics: Animals; Anxiety; Convulsants; Creatine; Depression; Dose-Response Relationship, Drug; Glutathione; | 2021 |
Rapamycin attenuates depression and anxiety-like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats.
Topics: Animals; Anxiety; Depression; Kindling, Neurologic; Male; NLR Family, Pyrin Domain-Containing 3 Prot | 2021 |
Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Dose-Response Relationship, Dru | 2021 |
Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies.
Topics: Animals; Anticonvulsants; Anxiety; Chromatography, Liquid; Depression; Kindling, Neurologic; Mice; P | 2021 |
Replicable in vivo physiological and behavioral phenotypes of the
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Biomarkers; Convulsants; Disease Models, Anim | 2017 |
Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Ethanol; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2018 |
The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Brain; Convulsants; Kindling, Neurologic; Male; | 2018 |
Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility.
Topics: Animals; Anxiety; Avoidance Learning; Brain Waves; Convulsants; Disease Models, Animal; Disease Susc | 2019 |
Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse.
Topics: Adaptation, Ocular; Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Fear | 2013 |
Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Female; Humans; | 2013 |
One for all and all for one: the importance of shoaling on behavioral and stress responses in zebrafish.
Topics: Animals; Anxiety; Hydrocortisone; Male; Pentylenetetrazole; Social Behavior; Stress, Psychological; | 2013 |
GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Electroencephalography; Emotions; GABA Antagonis | 2013 |
CNS depressant and anticonvulsant activities of the alcoholic extract of leaves of Ziziyphus nummularia.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Dose-Response Relationship, Drug; Female; Hy | 2014 |
Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.
Topics: Aggression; Anilides; Animals; Anxiety; Behavior, Animal; Brain; Child Development Disorders, Pervas | 2014 |
Esters of valerenic acid as potential prodrugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Esters; GABA Agents; Inden | 2014 |
Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice.
Topics: Acetylcholinesterase; Animals; Anxiety; Cognition; Cognition Disorders; Convulsants; Freeze Drying; | 2015 |
Pharmacological validation of the free-exploratory paradigm in male Wistar rats: A proposed test of trait anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Drug Evaluation, Preclinical; Exploratory Behavior; | 2015 |
Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats.
Topics: Animals; Anticonvulsants; Anxiety; Avoidance Learning; Cognition Disorders; Convulsants; DNA Damage; | 2015 |
The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Autistic Disorder; Behavior, Animal; Convulsants; Disease Mod | 2016 |
Anxiety-related behavioral responses of pentylenetetrazole-treated zebrafish larvae to light-dark transitions.
Topics: Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrocortisone; Larva; L | 2016 |
SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats.
Topics: Animals; Anxiety; Benzoxazoles; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Maze L | 2017 |
Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.
Topics: Angelman Syndrome; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Disease Models, Animal; F | 2017 |
Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease.
Topics: Animals; Antioxidants; Anxiety; Convulsants; Disease Models, Animal; Dual-Specificity Phosphatases; | 2017 |
Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial.
Topics: Animals; Anxiety; Behavior, Animal; Behavioral Research; Chlordiazepoxide; Emotions; Escape Reaction | 2008 |
Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cameroon; Convulsants; Diazepam; Dose-Respon | 2009 |
Pentylenetetrazole as an unconditioned stimulus for olfactory and contextual fear conditioning in rats.
Topics: Animals; Anxiety; Association Learning; Avoidance Learning; Conditioning, Classical; Discrimination | 2009 |
A rodent model of appetitive discrimination with concomitant evaluation of anxiety-like behavior.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Anxiety; Appetitive Behavior; Diazepam; Discrimination Learni | 2009 |
Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method.
Topics: Animals; Anticonvulsants; Anxiety; Dose-Response Relationship, Drug; Flavonoids; GABA Agonists; gamm | 2010 |
Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs.
Topics: Animals; Anxiety; Fear; Light; Male; Pentylenetetrazole; Photic Stimulation; Piperazines; Rats; Rats | 2010 |
Distinct models of induced hyperactivity in zebrafish larvae.
Topics: 4-Aminopyridine; Aconitine; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Respons | 2012 |
Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Convulsants; Disease Models, Animal; Electro | 2012 |
Neuropharmacological in vivo effects and phytochemical profile of the extract from the aerial parts of Heteropterys brachiata (L.) DC. (Malpighiaceae).
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Anxiety; Chlorogenic Acid; Fem | 2013 |
Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Dose-Response Relationship, Drug; GABA-B Receptor Agon | 2013 |
22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state.
Topics: Animals; Anxiety; Behavior, Animal; Buspirone; Carbolines; Conditioning, Classical; Diagnosis, Diffe | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti- | 2003 |
Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice.
Topics: Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety; Carbolines; Dextroamphetamine; Diaz | 2003 |
Differential effects of midazolam and pentylenetetrazole on behavioral repetition and variation.
Topics: Algorithms; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conditioning, Operant; Convulsa | 2004 |
Mouse grooming microstructure is a reliable anxiety marker bidirectionally sensitive to GABAergic drugs.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; GABA Agents; Grooming; Male; Mice | 2005 |
[A change in the alarm level entails a change in behavioural strategy of mice in stress and a change in analgesia induced by it].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Convulsants; Diazepam; Male; Mice; Pentylen | 2004 |
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.
Topics: Animals; Anxiety; Ataxia; Behavior, Animal; Benzodiazepines; Body Temperature; Body Weight; Cerebell | 2005 |
Behavioural characterization in rats using the elevated alley Suok test.
Topics: Animals; Anxiety; Ataxia; Behavioral Research; Disease Models, Animal; Exploratory Behavior; Male; M | 2005 |
Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions.
Topics: Alcohol Withdrawal Seizures; Animals; Anxiety; Ethanol; Female; Hyperkinesis; Male; Mice; Motor Acti | 2005 |
Changes in anxiety levels are followed by changes in behavioral strategy in mice subjected to stress and in the extent of stress-induced analgesia.
Topics: Adaptation, Physiological; Analgesia; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Convu | 2006 |
Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Central Nervous System Depressants; Ethanol; | 2006 |
Effects of sparfloxacin on CNS functions and urinary hydroxyproline in mice.
Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Fluoroqu | 2006 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behav | 2006 |
Participation of dihydrostyryl-2-pyrones and styryl-2-pyrones in the central effects of Polygala sabulosa (Polygalaceae), a folk medicine topical anesthetic.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Anti-Anxiety Agents; Anxiety; Convulsants; Dio | 2007 |
Pharmacological modulation of anxiety-related behaviors in the murine Suok test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Circadian Rhythm; Diazepam; Disease Models, | 2007 |
Anxiogenic and proconvulsant effect of gatifloxacin in mice.
Topics: Administration, Oral; Affect; Animals; Anti-Infective Agents; Anxiety; Behavior, Animal; Dose-Respon | 2008 |
Comparison of the actions of trimethadione and chlordiazepoxide in animal models of anxiety and benzodiazepine receptor binding.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conflict, Psychological; | 1982 |
Anxiogenic aspects of diazepam withdrawal can be detected in animals.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Discrimination Learning; Flumazenil; Humans; Male; Pe | 1983 |
The pentylenetetrazol model of anxiety detects withdrawal from diazepam in rats.
Topics: Animals; Anxiety; Diazepam; Discrimination Learning; Disease Models, Animal; Humans; Male; Pentylene | 1983 |
Discriminative stimulus properties of cocaine related to an anxiogenic action.
Topics: Animals; Anxiety; Cocaine; Diazepam; Discrimination, Psychological; Haloperidol; Humans; Male; Penty | 1981 |
Defeat engenders pentylenetetrazole-appropriate responding in rats: antagonism by midazolam.
Topics: Agonistic Behavior; Animals; Anxiety; Conditioning, Operant; Discrimination, Psychological; Flumazen | 1994 |
Ethopharmacological analysis of rat behavior on the elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Behavior, Animal; Carbolines; Explorato | 1994 |
Evidence for central benzodiazepine receptor heterogeneity from behavior tests.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Body Temperature; Central Nervous System; Dose- | 1994 |
Anxiogenic-like effects induced by stimulation of dopamine receptors.
Topics: Animals; Anxiety; Benzazepines; Carbolines; Dextroamphetamine; Diazepam; Dopamine Agents; Dopamine A | 1993 |
Behavioral and pharmacological validation of the elevated plus maze constructed with transparent walls.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Convulsants; Exploratory Behavior; Male | 1995 |
Evaluation of animal welfare by the self-expression of an anxiety state.
Topics: Animal Husbandry; Animal Welfare; Animals; Animals, Domestic; Anxiety; Behavior, Animal; Conditionin | 1995 |
High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.
Topics: Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyc | 1996 |
Ethopharmacological analysis of the effects of putative 'anxiogenic' agents in the mouse elevated plus-maze.
Topics: Animals; Anxiety; Appetite Depressants; Behavior, Animal; Carbolines; Dose-Response Relationship, Dr | 1995 |
A multiple-test study of anxiety-related behaviours in six inbred rat strains.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Diazepam | 1997 |
Short-term rebound anxiolytic effects and long-term changes in platelet benzodiazepine binding after pentylenetetrazole-kindling in two strains of rat.
Topics: Animals; Anxiety; Arousal; Benzodiazepinones; Blood Platelets; Isoquinolines; Kindling, Neurologic; | 1996 |
Some doubts about the basic concept of hole-board test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Chlordia | 1996 |
NMDA-coupled periaqueductal gray glycine receptors modulate anxioselective drug effects on plus-maze performance.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Binding, Competitive; Central Nervous System Stimulants; Diaz | 1998 |
Sensitisation of withdrawal signs following repeated withdrawal from a benzodiazepine: differences between measures of anxiety and seizure sensitivity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Conflict, Psychological | 1998 |
Effect of pentylenetetrazole on ethanol intake, ethanol kinetics, and social behavior in male Wistar rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety; Arousal; Convulsants; Drug Tolerance; Ethanol; Male; | 1998 |
[Effect of calcium channel blocker nifedipine on anxiety and seizure manifestations of abstinence syndrome in rats after withdrawal of long-term diazepam administration].
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Anxiety; Calcium Channel Blockers; Calcium | 1998 |
A primate model of anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Disease Models, Animal; Hydrocortisone; Macaca | 1998 |
Antagonism of kynurenic acid to anxiogens in mice.
Topics: Animals; Anxiety; Brain; Caffeine; Diazepam; Excitatory Amino Acid Antagonists; Injections, Intraper | 1998 |
Ethopharmacological analysis of behaviour of rats using variations of the elevated plus-maze.
Topics: Animals; Anxiety; Behavior, Animal; Convulsants; Factor Analysis, Statistical; GABA Modulators; gamm | 1997 |
Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Biological Availability; Cell Line; Cerebell | 1999 |
Differential change in neuroactive steroid sensitivity during ethanol withdrawal.
Topics: Administration, Inhalation; Alcohol Withdrawal Seizures; Animals; Anticonvulsants; Anxiety; Ataxia; | 2000 |
Prefrontal dopamine is directly involved in the anxiogenic interoceptive cue of pentylenetetrazol but not in the interoceptive cue of chlordiazepoxide in the rat.
Topics: Animals; Anxiety; Apomorphine; Chlordiazepoxide; Cues; Discrimination Learning; Dopamine; Dopamine A | 2000 |
Abecarnil and alprazolam reverse anxiety-like behaviors induced by ethanol withdrawal.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Discrimination Lear | 2000 |
Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cocaine; Convulsants; Diazepam; Dopamine Upt | 2000 |
Use of negatively reinforcing electrical brain stimulation to detect conventional and nonconventional anxiolytics as well as an anxiogenic drug.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Buspirone; Carbolines; Convulsants; Diazepam; Electric | 2001 |
Characterization of alpha-casozepine, a tryptic peptide from bovine alpha(s1)-casein with benzodiazepine-like activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding Sites; Caseins; Cat | 2001 |
Reduced anxiety-- and depression-like behaviors in Emx1 homozygous mutant mice.
Topics: Acoustic Stimulation; Animals; Anxiety; Convulsants; Depression; Exploratory Behavior; Female; Genet | 2002 |
Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Ca | 2002 |
A synthetic non-benzodiazepine ligand for benzodiazepine receptors: a probe for investigating neuronal substrates of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Body Temperature; Conflict, Psychological; g | 1979 |
[Experimental characteristics of the spectrum of pharmacologic activity of the tranquilizer lorazepam].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Chlordiazepoxide; Conflict, Psychological; D | 1975 |
The anxiogenic-like effects of pentylenetetrazole in mice treated chronically with carbamazepine or valproate.
Topics: Animals; Anxiety; Behavior, Animal; Carbamazepine; Female; Lorazepam; Mice; Pentylenetetrazole; Valp | 1992 |
Anxiety-induced antinociception in the mouse.
Topics: Analgesia; Animals; Anxiety; Male; Mice; Pain; Pain Measurement; Pentylenetetrazole; Random Allocati | 1992 |
Comparison of behavioral and central BDZ binding profile in three rat lines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Binding, Competitive; Body | 1992 |
Chlordiazepoxide reduces the generalised anxiety, but not the direct responses, of rats exposed to cat odor.
Topics: Animals; Anxiety; Cats; Chlordiazepoxide; Fear; Male; Pentylenetetrazole; Rats; Smell | 1992 |
beta-Carboline and pentylenetetrazol effects on conflict behavior in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Conflict, Psychological; Dose-Response Relationship, | 1992 |
The detection of changes in psychological state using a novel pharmacological conditioning procedure.
Topics: Animals; Anxiety; Cues; Discrimination Learning; Disease Models, Animal; Male; Pentylenetetrazole; R | 1992 |
Behavioural effects of anxiogenic agents in the common marmoset.
Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Caffeine; Callithrix; Carbolines; Diazepam; Motor A | 1992 |
Protracted withdrawal: sensitization of the anxiogenic response to cocaine in rats concurrently treated with ethanol.
Topics: Alcoholism; Animals; Anxiety; Cocaine; Discrimination Learning; Discrimination, Psychological; Drug | 1992 |
Effects of DN-2327, a new anxiolytic, diazepam and buspirone on exploratory activity of the rat in an elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Conflict, Psychological; Diazepam; Dose-Response R | 1991 |
Pentylenetetrazole can induce a conditioned place preference.
Topics: Animals; Anxiety; Conditioning, Classical; Discrimination Learning; Disease Models, Animal; Male; Pe | 1991 |
Selective effect on punished versus unpunished responding in a conflict test as the criterion for anxiogenic activity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Conflict, Psychological; Electroshock; Male; Pent | 1990 |
The long-term effects of diazepam and pentylenetetrazol on the potentiated startle response.
Topics: Acoustic Stimulation; Animals; Anxiety; Conditioning, Classical; Diazepam; Electroshock; Male; Penty | 1990 |
Sodium phenobarbitone reverses the anxiogenic effects of compounds acting at three different central sites.
Topics: Animals; Anxiety; Appetite Depressants; Carbolines; Exploratory Behavior; Male; Pentylenetetrazole; | 1989 |
Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration.
Topics: Anxiety; Brain; Epilepsy; Female; Indoles; Isatin; Liver; Male; Monoamine Oxidase Inhibitors; Pentyl | 1989 |
Anxiogenic effects of drug withdrawal.
Topics: Animals; Anxiety; Disease Models, Animal; Humans; Pentylenetetrazole; Psychotropic Drugs; Rats; Subs | 1989 |
The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin.
Topics: Animals; Anxiety; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; G | 1989 |
Can anti-panic drugs antagonise the anxiety produced in the rat by drugs acting at the GABA-benzodiazepine receptor complex?
Topics: Animals; Anxiety; Carbolines; Clonidine; Fear; Imipramine; Male; Panic; Pentylenetetrazole; Rats; Ra | 1987 |
Self-regulation of ICSS duration: effects of anxiogenic substances, benzodiazepine antagonists and antidepressants.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Benzodia | 1985 |
Animal models for the study of anti-anxiety agents: a review.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Cats; Condi | 1985 |
Interoceptive stimuli produced by an anxiogenic drug are mimicked by benzodiazepine antagonists in rats pretreated with isoniazid.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Brain Chemistry; Convulsants; Discriminati | 1985 |
Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Brain; Carbolines; Male; Motor A | 1985 |
Bidirectional modulation of GABA function by beta-carbolines.
Topics: Acoustic Stimulation; Anesthesia, General; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning | 1986 |
Chronic treatment with imipramine does not reverse the effects of 3 anxiogenic compounds in a test of anxiety in the rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Drug Combinations; Imipramine; Male; Pentylenetet | 1987 |
The benzodiazepine receptor inverse agonists beta-CCM and RO 15-3505 both reverse the anxiolytic effects of ethanol in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Carboli | 1988 |
Characterization of a pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal.
Topics: Animals; Anxiety; Conditioning, Operant; Discrimination Learning; Ethanol; Food; Male; Pentylenetetr | 1988 |
Comparison of adaptive responses in familiar and novel environments: modulatory factors.
Topics: Adaptation, Psychological; Animals; Anxiety; Carbolines; Environment; Grooming; Pentylenetetrazole; | 1988 |
Anxiety in the rat is associated with decreased release of 5-HT and glycine from the hippocampus.
Topics: Animals; Anxiety; Glycine; Hippocampus; Injections, Intraperitoneal; Male; Pentylenetetrazole; Rats; | 1987 |
Anxiogenic properties of cocaine withdrawal.
Topics: Animals; Anxiety; Cocaine; Male; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1987 |
Anxiety-like subjective effect of ethanol antagonist RO 15-4513 demonstrated in pentylenetetrazol discrimination.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Diazepam; Discrimination, Psychological; Male; Pentylenet | 1987 |
Pyrazapon (CI-683): a new antianxiety agent.
Topics: Animals; Anticonvulsants; Anxiety; Azepines; Behavior, Animal; Blood Pressure; Chlordiazepoxide; Con | 1974 |
Neuropharmacology of SQ 10,996, a compound with several therapeutic indications.
Topics: Amides; Animals; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Carbamazepine; C | 1973 |
[Medical aspects of anxiety].
Topics: Angina Pectoris; Anxiety; Bipolar Disorder; Brain; Humans; Limbic System; Neurotic Disorders; Pentyl | 1973 |