pentylenetetrazole has been researched along with Anoxemia in 32 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 7.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice." | 7.67 | Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia. ( Bartolini, A; Bennardini, F; Franconi, F; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P, 1989) |
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 3.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice." | 3.67 | Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia. ( Bartolini, A; Bennardini, F; Franconi, F; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P, 1989) |
| "Seizures induced in the rat by electroshock or by injections of pentylenetetrazol increase the specific binding of diazepam to putative receptor sites in cerebral cortical membranes." | 3.66 | Rapid changes in brain benzodiazepine receptors after experimental seizures. ( Paul, SM; Skolnick, P, 1978) |
| "The concentration of adenosine triphosphate in the brain decreased before the onset of generalized convulsions in unanesthetized rats subjected to acute hypoxia or treated with hydroxylamine or pentylenetetrazole (Metrazol)." | 3.65 | Brain adenosine triphosphate: decreased concentration precedes convulsions. ( Currie, WD; Kramer, RS; Sanders, AP; Woodhall, B, 1970) |
| "Seizures were induced in rats (postnatal day 10) by 5% O2 exposure for 15 min." | 1.62 | FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation. ( Farbood, Y; Ghafouri, S; Najafian, SA; Sarkaki, A, 2021) |
| "After PTZ or flurothyl seizures, both ages exhibited similar patterns of IR in amygdala, pyriform cortex, and hypothalamus." | 1.29 | Differences in c-fos immunoreactivity due to age and mode of seizure induction. ( Firkusny, IR; Jensen, FE; Mower, GD, 1993) |
| "Intensity of convulsions was expressed in points." | 1.28 | [Corazol kindling in rats with different tolerance to hypoxia]. ( Agadzhanian, NA; Kryzhanovskiĭ, GN; Starykh, EV; Torshin, VI, 1991) |
| "Transient systemic hypercapnic anoxia (22-sec exposure to 100% CO2 gas), before treatment with NMDA did not significantly reduce the NMDA-induced behavior." | 1.28 | Cerebral ischemia decreases the behavioral effects and mortality rate elicited by activation of NMDA receptors in mice. ( Himori, N; Martin, JR; Moreau, JL, 1991) |
| "Convulsions were caused by intraabdominal injections of corazol." | 1.28 | [Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis]. ( Agadzhanian, NA; Starykh, EV; Torshin, VI, 1991) |
| "However, the susceptibility to seizures induced by PTZ, which was measured by the mean number of generalized convulsions (GCs) as well as a mean duration of the 1st GC and severity score, was more enhanced in the rats exposed to perinatal hypoxia than in the control group at every age." | 1.28 | The effects of perinatal hypoxia on pentylenetetrazol-induced seizures in developing rats. ( Matsumoto, M, 1990) |
| "Epileptiform convulsions occurred in presentation of "difficult" experimental tasks." | 1.26 | [Characteristics of the function of the higher portions of the central nervous system of rats subjected to acute hypoxia in the antenatal period]. ( Kruglikov, RI; Maĭzelis, MIa; Zabludovskiĭ, AL, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (56.25) | 18.7374 |
| 1990's | 10 (31.25) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Najafian, SA | 1 |
| Farbood, Y | 1 |
| Sarkaki, A | 1 |
| Ghafouri, S | 1 |
| Karimzadeh, F | 1 |
| Hosseini, M | 1 |
| Mangeng, D | 1 |
| Alavi, H | 1 |
| Hassanzadeh, GR | 1 |
| Bayat, M | 1 |
| Jafarian, M | 1 |
| Kazemi, H | 1 |
| Gorji, A | 1 |
| Rakhade, SN | 1 |
| Fitzgerald, EF | 1 |
| Klein, PM | 1 |
| Zhou, C | 1 |
| Sun, H | 1 |
| Huganir, RL | 1 |
| Hunganir, RL | 1 |
| Jensen, FE | 2 |
| TEWS, JK | 1 |
| CARTER, SH | 1 |
| ROA, PD | 1 |
| STONE, WE | 1 |
| HOHMANN, G | 1 |
| King, LJ | 1 |
| Lowry, OH | 1 |
| Passonneau, JV | 1 |
| Venson, V | 1 |
| Dóra, E | 1 |
| Kovách, AG | 1 |
| Li, YW | 1 |
| Zhu, XY | 1 |
| But, PP | 1 |
| Yeung, HW | 1 |
| Rauca, C | 2 |
| Rüthrich, HL | 1 |
| Domány, G | 1 |
| Barta-Szalai, G | 1 |
| Pálosi, E | 1 |
| Szabó, S | 1 |
| Schön, I | 1 |
| Firkusny, IR | 1 |
| Mower, GD | 1 |
| Agadzhanian, NA | 4 |
| Torshin, VI | 4 |
| Shevchenko, LV | 2 |
| Elfimov, AI | 2 |
| Jantze, H | 1 |
| Krug, M | 1 |
| Kontos, HA | 1 |
| Wei, EP | 1 |
| Raper, AJ | 1 |
| Rosenblum, WI | 2 |
| Navari, RM | 1 |
| Patterson, JL | 1 |
| Paul, SM | 1 |
| Skolnick, P | 1 |
| Zabludovskiĭ, AL | 1 |
| Maĭzelis, MIa | 1 |
| Kruglikov, RI | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Starykh, EV | 2 |
| Himori, N | 1 |
| Moreau, JL | 1 |
| Martin, JR | 1 |
| Matsumoto, M | 1 |
| Malcangio, M | 1 |
| Bartolini, A | 1 |
| Ghelardini, C | 1 |
| Bennardini, F | 1 |
| Malmberg-Aiello, P | 1 |
| Franconi, F | 1 |
| Giotti, A | 1 |
| LaManna, JC | 1 |
| McCracken, KA | 1 |
| Patil, M | 1 |
| Prohaska, OJ | 1 |
| Fischer, HD | 1 |
| Endtricht, AK | 1 |
| Giele, M | 1 |
| Grahlmann, D | 1 |
| Andreas, K | 1 |
| Jähkel, M | 1 |
| Oehler, J | 1 |
| Rudolph, E | 1 |
| Schmidt, J | 1 |
| Wustmann, C | 1 |
| Giurgea, C | 1 |
| Mouravieff-Lesuisse, F | 1 |
| Leemans, R | 1 |
| Dobkin, AB | 1 |
| Su, JP | 1 |
| Byles, PH | 1 |
| Jöbsis, FF | 1 |
| O'Connor, M | 1 |
| Vitale, A | 1 |
| Vreman, H | 1 |
| Sanders, AP | 1 |
| Kramer, RS | 1 |
| Woodhall, B | 1 |
| Currie, WD | 1 |
| Yoshino, Y | 2 |
| Elliott, KA | 2 |
| Brekhman, II | 1 |
| Nesterenko, IF | 1 |
32 other studies available for pentylenetetrazole and Anoxemia
| Article | Year |
|---|---|
FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation.
Topics: Aging; Animals; Animals, Newborn; Cognitive Dysfunction; Epilepsy; Female; Fingolimod Hydrochloride; | 2021 |
Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain.
Topics: Animals; Anticonvulsants; Brain; Hippocampus; Hypoxia; Long-Term Potentiation; Male; Neurons; Neurop | 2012 |
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks La | 2012 |
FREE AMINO ACIDS AND RELATED COMPOUNDS IN DOG BRAIN: POST-MORTEM AND ANOXIC CHANGES, EFFECTS OF AMMONIUM CHLORIDE INFUSION, AND LEVELS DURING SEIZURES INDUCED BY PICROTOXIN AND BY PENTYLENETETRAZOL.
Topics: Amino Acids; Ammonium Chloride; Autopsy; Brain; Dogs; Hypoxia; Pathology; Pentylenetetrazole; Pharma | 1963 |
[Combined analeptic and hypoxia-preventive treatment with recovery in a severe case of narcotic poisoning].
Topics: Central Nervous System Stimulants; Humans; Hypoxia; Narcotics; Pentylenetetrazole; Physiological Phe | 1955 |
Effects of convulsants on energy reserves in the cerebral cortex.
Topics: Animals; Centrifugation; Cerebral Cortex; Chlorpromazine; Electric Stimulation; Electroshock; Freezi | 1967 |
Glycolysis and regulation of cerebral blood flow and metabolism.
Topics: Animals; Brain; Cats; Cerebrovascular Circulation; Glycolysis; Hypoxia; Iodoacetates; Iodoacetic Aci | 1984 |
Ethnopharmacology of bear gall bladder: I.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Bile; Bile Ac | 1995 |
Moderate hypoxia reduces pentylenetetrazol-induced seizures.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agents; Hypoxia; Male; Mice; Mice, Inbred Strain | 1995 |
New 4-arylaminopiperidines with antihypoxic and anticonvulsive activity.
Topics: Animals; Anticonvulsants; Cell Survival; Cyanides; Hypoxia; Male; Mice; Mice, Inbred Strains; Pentyl | 1994 |
Differences in c-fos immunoreactivity due to age and mode of seizure induction.
Topics: Aging; Animals; Flurothyl; Hypoxia; Immunohistochemistry; Pentylenetetrazole; Proto-Oncogene Protein | 1993 |
[Effect of carotid glomectomy on seizures induced by corasol].
Topics: Acute Disease; Animals; Carotid Body; Convulsants; Hypoxia; Male; Pentylenetetrazole; Rats; Reflex; | 1998 |
Does fucose or piracetam modify the effect of hypoxia preconditioning against pentylenetetrazol-induced seizures?
Topics: Animals; Fucose; Hypoxia; Male; Neuroprotective Agents; Pentylenetetrazole; Piracetam; Rats; Rats, W | 2000 |
Role of tissue hypoxia in local regulation of cerebral microcirculation.
Topics: Animals; Arterioles; Carbon Dioxide; Cats; Cerebrospinal Fluid; Cerebrovascular Circulation; Female; | 1978 |
Rapid changes in brain benzodiazepine receptors after experimental seizures.
Topics: Animals; Binding Sites; Brain; Cerebral Cortex; Diazepam; Electroshock; Hypoxia; Kinetics; Male; Pen | 1978 |
[Characteristics of the function of the higher portions of the central nervous system of rats subjected to acute hypoxia in the antenatal period].
Topics: Acute Disease; Altitude; Animals; Atmosphere Exposure Chambers; Central Nervous System; Conditioning | 1976 |
[Corazol kindling in rats with different tolerance to hypoxia].
Topics: Animals; Hypoxia; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Seizures; Time Factors | 1991 |
Cerebral ischemia decreases the behavioral effects and mortality rate elicited by activation of NMDA receptors in mice.
Topics: Animals; Behavior, Animal; Carbon Dioxide; Dizocilpine Maleate; Female; Hypoxia; Injections, Intrave | 1991 |
[Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis].
Topics: Age Factors; Animals; Animals, Newborn; Atmosphere Exposure Chambers; Disease Models, Animal; Diseas | 1991 |
The effects of perinatal hypoxia on pentylenetetrazol-induced seizures in developing rats.
Topics: Animals; Animals, Newborn; Brain; Hypoxia; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Sei | 1990 |
[Effects of acute hypoxia on the development of corazol-induced seizures].
Topics: Acute Disease; Animals; Epilepsy; Hypoxia; Injections, Subcutaneous; Male; Pentylenetetrazole; Rats | 1990 |
Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia.
Topics: Amnesia; Animals; Anticonvulsants; Avoidance Learning; Hypoxia; Injections, Intraventricular; Learni | 1989 |
Stimulus-activated changes in brain tissue temperature in the anesthetized rat.
Topics: Anesthesia; Animals; Body Temperature; Brain; Chloral Hydrate; Electric Stimulation; Electroencephal | 1989 |
Posthypoxic transmitter release from brain slices and behavioural consequences of hypoxia in rats and mice.
Topics: Animals; Atmospheric Pressure; Behavior, Animal; Brain; Dopamine; Hypoxia; In Vitro Techniques; Mice | 1985 |
Correlations between electrical and pharmacological observations during anoxia in the rabbit, in normal and assisted respiration.
Topics: Amphetamine; Brain; Caffeine; Electroencephalography; Ethylamines; Hypoxia; Meclofenoxate; Methylphe | 1971 |
Fluorocarbon emulsion as a blood substitute: cerebral microcirculation and related parameters.
Topics: Animals; Blood Transfusion; Blood Viscosity; Brain; Cerebrovascular Circulation; Electrocardiography | 1974 |
The efficacy of managing postanaesthetic respiratory depression with analeptics.
Topics: Abdomen; Adult; Aged; Aminobutyrates; Anesthesia, General; Animals; Arousal; Bemegride; Benzamides; | 1966 |
Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity.
Topics: Adenosine Diphosphate; Animals; Blood Pressure; Cats; Cerebral Cortex; Fluorometry; Hypoxia; Mitocho | 1971 |
Brain adenosine triphosphate: decreased concentration precedes convulsions.
Topics: Adenosine Triphosphate; Animals; Brain; Hydroxylamines; Hypoxia; Male; Pentylenetetrazole; Rats; Sei | 1970 |
Effects of various conditions on the movement of carbon atoms derived from glucose into and out of protein in rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Cerebral Cortex; | 1970 |
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; | 1970 |
[Tranquilizing effect of saiga horn extract].
Topics: Amphetamine; Analgesics; Animals; Anticonvulsants; Barbiturates; Depression, Chemical; Electroshock; | 1971 |