pentylenetetrazole has been researched along with Amnesia in 28 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study we examined the effect of post-training administered calcium channel blockers nifedipine (10 and 40 mg/kg) and diltiazem (10 and 30 mg/kg) on amnesia induced by PTZ kindling in shuttle-box- and step-down-trained rats." | 7.71 | Effect of the calcium channel blockers nifedipine and diltiazem on pentylenetetrazole kindling-provoked amnesia in rats. ( Genkova-Papazova, MG; Lazarova-Bakarova, M; Petkova, B; Shishkova, N, 2001) |
| "The effect of adenosine agents on amnesia induced by pentylenetetrazole was examined in mice." | 7.71 | Effects of adenosine receptor agonists and antagonists on pentylenetetrazole-induced amnesia. ( Homayoun, H; Khavandgar, S; Zarrindast, MR, 2001) |
| "The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice." | 7.67 | Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia. ( Bartolini, A; Bennardini, F; Franconi, F; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P, 1989) |
| " Cycloheximide, which antagonizes the puromycin-induced amnesia 3 hours after training, also antagonizes the puromycin effect on susceptibility to seizure." | 7.64 | Puromycin effect on memory may be due to occult seizures. ( Barondes, SH; Cohen, HD, 1967) |
| " Active compounds exhibited an inverted U-shaped dose-response curve." | 5.27 | Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam. ( Butler, DE; L'Italien, YJ; Marriott, JG; Nordin, IC; Poschel, PH; Zweisler, L, 1984) |
| " In the present study we examined the effect of post-training administered calcium channel blockers nifedipine (10 and 40 mg/kg) and diltiazem (10 and 30 mg/kg) on amnesia induced by PTZ kindling in shuttle-box- and step-down-trained rats." | 3.71 | Effect of the calcium channel blockers nifedipine and diltiazem on pentylenetetrazole kindling-provoked amnesia in rats. ( Genkova-Papazova, MG; Lazarova-Bakarova, M; Petkova, B; Shishkova, N, 2001) |
| "The effect of adenosine agents on amnesia induced by pentylenetetrazole was examined in mice." | 3.71 | Effects of adenosine receptor agonists and antagonists on pentylenetetrazole-induced amnesia. ( Homayoun, H; Khavandgar, S; Zarrindast, MR, 2001) |
| "The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice." | 3.67 | Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia. ( Bartolini, A; Bennardini, F; Franconi, F; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P, 1989) |
| " Cycloheximide, which antagonizes the puromycin-induced amnesia 3 hours after training, also antagonizes the puromycin effect on susceptibility to seizure." | 3.64 | Puromycin effect on memory may be due to occult seizures. ( Barondes, SH; Cohen, HD, 1967) |
| " Active compounds exhibited an inverted U-shaped dose-response curve." | 1.27 | Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam. ( Butler, DE; L'Italien, YJ; Marriott, JG; Nordin, IC; Poschel, PH; Zweisler, L, 1984) |
| "The data suggest that overt convulsions may be necessary for the development of pentylenetetrazol-induced retrograde amnesia." | 1.26 | Pentylenetetrazol-induced amnesia: a case for overt seizures. ( Albala, B; Palfai, T, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (75.00) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, DE | 1 |
| Nordin, IC | 1 |
| L'Italien, YJ | 1 |
| Zweisler, L | 1 |
| Poschel, PH | 1 |
| Marriott, JG | 1 |
| Nkwingwa, BK | 1 |
| Wado, EK | 1 |
| Foyet, HS | 1 |
| Bouvourne, P | 1 |
| Jugha, VT | 1 |
| Mambou, AHMY | 1 |
| Bila, RB | 1 |
| Taiwe, GS | 1 |
| Godinho, M | 1 |
| Ribeiro, AM | 1 |
| Fernandes, VS | 1 |
| Barbosa, FF | 1 |
| Nascimento, EB | 1 |
| Munguba, H | 1 |
| Silva, RH | 1 |
| ASCHENBACH, EH | 1 |
| PEARLMAN, CA | 1 |
| SHARPLESS, SK | 1 |
| JARVIK, ME | 1 |
| JERVIS, G | 1 |
| SERGIO, C | 1 |
| Cohen, HD | 1 |
| Barondes, SH | 1 |
| Oscós-Alvarado, A | 1 |
| Martínez de Muñoz, D | 1 |
| Martin, JR | 1 |
| Schoch, P | 1 |
| Jenck, F | 1 |
| Moreau, JL | 1 |
| Haefely, WE | 1 |
| Genkova-Papazova, MG | 3 |
| Lazarova-Bakarova, MB | 1 |
| Petkova, B | 2 |
| Shishkova, N | 2 |
| Lazarova-Bakarova, M | 2 |
| Homayoun, H | 1 |
| Khavandgar, S | 1 |
| Zarrindast, MR | 1 |
| Banerjee, U | 2 |
| Das, P | 2 |
| Bookin, HB | 2 |
| Pfeifer, WD | 2 |
| Iuvone, PM | 1 |
| Boast, CA | 1 |
| Gray, HE | 1 |
| Dunn, AJ | 1 |
| Palfai, T | 3 |
| Albala, B | 1 |
| Malcangio, M | 1 |
| Bartolini, A | 1 |
| Ghelardini, C | 1 |
| Bennardini, F | 1 |
| Malmberg-Aiello, P | 1 |
| Franconi, F | 1 |
| Giotti, A | 1 |
| Weissman, A | 1 |
| van Buskirk, R | 1 |
| McGaugh, JL | 1 |
| Kurtz, P | 1 |
| Neki, JS | 1 |
| Kishore, B | 1 |
| Ahlers, RH | 1 |
| Best, PJ | 1 |
| Vinitskiĭ, IM | 1 |
| Abuladze, GV | 1 |
| Chillag, D | 1 |
| Nieschulz, O | 1 |
1 review available for pentylenetetrazole and Amnesia
| Article | Year |
|---|---|
Drugs and retrograde amnesia.
Topics: Amnesia; Anesthesia, General; Animals; Anticonvulsants; Azaguanine; Barbiturates; Behavior, Animal; | 1967 |
27 other studies available for pentylenetetrazole and Amnesia
| Article | Year |
|---|---|
Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam.
Topics: Amnesia; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Huma | 1984 |
Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems.
Topics: Albizzia; Amnesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Epilepsy; gamma | 2023 |
A rodent model of appetitive discrimination with concomitant evaluation of anxiety-like behavior.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Anxiety; Appetitive Behavior; Diazepam; Discrimination Learni | 2009 |
The use of metrazol in non-institutionalized elderly patients.
Topics: Aged; Amnesia; Disease; Humans; Patients; Pentylenetetrazole | 1956 |
Retrograde amnesia produced by anesthetic and convulsant agents.
Topics: Amnesia; Amnesia, Retrograde; Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthetics; Convulsa | 1961 |
[PERMANENT DEFICIENCY OF FIXATION MEMORY AFTER UNILATERAL TEMPORAL LOBECTOMY IN AN EPILEPTIC SUBJECT].
Topics: Amnesia; Bemegride; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Cloni | 1964 |
Puromycin effect on memory may be due to occult seizures.
Topics: Amnesia; Animals; Behavior, Animal; Brain; Cycloheximide; Drug Antagonism; Humans; Memory; Mice; Ner | 1967 |
Effects of 4-hydroxy, 4-phenyl, caproamide on pentylenetetrazol-induced amnesia.
Topics: Amides; Amnesia; Animals; Anticonvulsants; Avoidance Learning; Humans; Male; Mice; Pentylenetetrazol | 1981 |
Pharmacological characterization of benzodiazepine receptor ligands with intrinsic efficacies ranging from high to zero.
Topics: Acoustic Stimulation; Amnesia; Animals; Anticonvulsants; Conditioning, Operant; Eating; Female; Flum | 1993 |
Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats.
Topics: Amnesia; Animals; Avoidance Learning; Kindling, Neurologic; Male; Pentylenetetrazole; Piperazines; P | 1996 |
The GABA-B antagonist CGP 36742 prevent PTZ-kindling-provoked amnesia in rats.
Topics: Amnesia; Animals; Avoidance Learning; Epilepsy; GABA Antagonists; Kindling, Neurologic; Male; Organo | 2000 |
Effect of the calcium channel blockers nifedipine and diltiazem on pentylenetetrazole kindling-provoked amnesia in rats.
Topics: Amnesia; Animals; Avoidance Learning; Calcium Channel Blockers; Convulsants; Diltiazem; Kindling, Ne | 2001 |
Effects of adenosine receptor agonists and antagonists on pentylenetetrazole-induced amnesia.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amnesia; Analysis of Variance; Animals; Avoidance Lear | 2001 |
Comparative study of retrograde amnesia in rats on active and passive avoidance tasks and spontaneous recovery of memory.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Electroshock; Ether; Female; Humans; Male | 1977 |
Effect of lysine vasopressin on pentylenetetrazol-induced retrograde amnesia in rats.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Humans; Lypressin; Male; Memory; Pentylen | 1977 |
Pentylenetetrazol: inhibitory avoidance behavior, brain seizure activity, and [3H]lysine incorporation into brain proteins of different mouse strains.
Topics: Amnesia; Animals; Avoidance Learning; Brain; Cerebral Cortex; Electroencephalography; Hippocampus; H | 1977 |
Vasopressin antagonizes retrograde amnesia in rats following electroconvulsive shock.
Topics: Amnesia; Amnesia, Retrograde; Animals; Carbon Dioxide; Electroshock; Humans; Lypressin; Male; Memory | 1978 |
Pentylenetetrazol-induced amnesia: a case for overt seizures.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Humans; | 1976 |
Variable temporal gradients of retrograde amnesia: contingency on tasks and species.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Electroshock; Escape Reaction; Female; Hu | 1976 |
Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia.
Topics: Amnesia; Animals; Anticonvulsants; Avoidance Learning; Hypoxia; Injections, Intraventricular; Learni | 1989 |
Pentylenetetrazol-induced retrograde amnesia and brain seizures in mice.
Topics: Amnesia; Animals; Avoidance Learning; Cerebral Cortex; Dose-Response Relationship, Drug; Electrodes, | 1974 |
State-dependent learning produced by Metrazol.
Topics: Amnesia; Animals; Avoidance Learning; Discrimination Learning; Exploratory Behavior; Housing, Animal | 1973 |
Narcostimulation in depressive states.
Topics: Accidents; Amnesia; Anesthesia; Apnea; Central Nervous System; Convulsive Therapy; Depression; Elect | 1968 |
Retrograde amnesia for discriminated taste aversions: a memory deficit.
Topics: Amnesia; Animals; Apomorphine; Association; Avoidance Learning; Conditioning, Psychological; Discrim | 1972 |
[Retrograde amnesia induced by corazole against a background of anesthesia].
Topics: Amnesia; Anesthesia, General; Animals; Conditioning, Classical; Escape Reaction; Ethyl Ethers; Human | 1971 |
Time-dependent memory deficits produced by pentylene-tetrazol (Metrazol)--the effect of reinforcement magnitude.
Topics: Amnesia; Animals; Avoidance Learning; Conditioning, Psychological; Electroshock; Female; Humans; Mal | 1971 |
[Experimental retrograde amnesias in mice].
Topics: Amnesia; Animals; Behavior, Animal; Brain Injuries; Humans; Mice; Pentylenetetrazole; Seizures | 1967 |