pentylenetetrazole has been researched along with Ambulation Disorders, Neurologic in 3 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 3,5-DBr-L-Phe was also given as a single bolus prior to pentylenetetrazole (PTZ) injection to induce seizures or prior to the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) to cause disruption of prepulse inhibition (PPI) of startle (sensorimotor gating deficit)." | 7.75 | Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. ( Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2009) |
| " 3,5-DBr-L-Phe was also given as a single bolus prior to pentylenetetrazole (PTZ) injection to induce seizures or prior to the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) to cause disruption of prepulse inhibition (PPI) of startle (sensorimotor gating deficit)." | 3.75 | Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. ( Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2009) |
| "In two chemically induced seizure models, mice with reduced tau protein had less severe seizures than control mice." | 1.39 | Antisense reduction of tau in adult mice protects against seizures. ( Bennett, CF; Chen, G; Cirrito, JR; DeVos, SL; Goncharoff, DK; Holtzman, DM; Kebodeaux, CS; Maloney, SE; Miller, TM; Rigo, F; Schuler, DR; Stewart, FR; Wozniak, DF; Yamada, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DeVos, SL | 1 |
| Goncharoff, DK | 1 |
| Chen, G | 1 |
| Kebodeaux, CS | 1 |
| Yamada, K | 1 |
| Stewart, FR | 1 |
| Schuler, DR | 1 |
| Maloney, SE | 1 |
| Wozniak, DF | 1 |
| Rigo, F | 1 |
| Bennett, CF | 1 |
| Cirrito, JR | 1 |
| Holtzman, DM | 1 |
| Miller, TM | 1 |
| Cao, W | 1 |
| Shah, HP | 1 |
| Glushakov, AV | 1 |
| Mecca, AP | 1 |
| Shi, P | 1 |
| Sumners, C | 1 |
| Seubert, CN | 1 |
| Martynyuk, AE | 1 |
| Chiu, CS | 1 |
| Brickley, S | 1 |
| Jensen, K | 1 |
| Southwell, A | 1 |
| Mckinney, S | 1 |
| Cull-Candy, S | 1 |
| Mody, I | 1 |
| Lester, HA | 1 |
3 other studies available for pentylenetetrazole and Ambulation Disorders, Neurologic
| Article | Year |
|---|---|
Antisense reduction of tau in adult mice protects against seizures.
Topics: Age Factors; Animals; Anticonvulsants; Central Nervous System; Convulsants; Disease Models, Animal; | 2013 |
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Endothelin-1; Gait Disorders, Neurologic; Glut | 2009 |
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.
Topics: Animals; Anxiety; Ataxia; Behavior, Animal; Benzodiazepines; Body Temperature; Body Weight; Cerebell | 2005 |