pentylenetetrazole has been researched along with Alcoholism in 12 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we expand on these findings to test whether ethosuximide can reduce the sensitivity to pentylenetetrazole-induced seizures during ethanol withdrawal." | 3.81 | Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal. ( Godwin, DW; Masicampo, ML; Riegle, MA; Shan, HQ; Xu, V, 2015) |
| "Twice-daily dosing of khat did not produce inhibition of weight gain." | 1.37 | Khat (Catha edulis) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model. ( Alele, PE; Rujumba, JB, 2011) |
| "This ethanol-induced increase in seizure rating was unaffected by carbamazepine (30 mg kg(-1)) but significantly reduced at a higher concentration (130 mg kg(-1))." | 1.30 | Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro. ( Boden, PR; Field, MJ; Ibbotson, T, 1997) |
| " The long-lasting decrease in seizure threshold following CIE treatment resembled the "kindling" phenomenon produced by chronic administration of PTZ (25 mg/kg, 3 times/week)." | 1.29 | The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol. ( Kokka, N; Olsen, RW; Sapp, DW; Taylor, AM, 1993) |
| " In the pair-fed controls, or rats withdrawn from the smaller dosage of either ethanol or cocaine, the test dose of saline or cocaine did not elicit the PTZ-stimulus; only 30% of rats selected the PTZ-appropriate level at the highest dose of cocaine tested (10 mg/kg)." | 1.28 | Protracted withdrawal: sensitization of the anxiogenic response to cocaine in rats concurrently treated with ethanol. ( Lal, H; Prather, PL, 1992) |
| "Mice treated with tryptophol plus ethanol became highly susceptible to convulsion." | 1.26 | Changes in seizure susceptibility after successive treatments of mice with tryptophol and ethanol. ( Fukumori, R; Kitagawa, H; Minegishi, A; Satoh, T, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Riegle, MA | 1 |
| Masicampo, ML | 1 |
| Shan, HQ | 1 |
| Xu, V | 1 |
| Godwin, DW | 1 |
| Alele, PE | 1 |
| Rujumba, JB | 1 |
| Fukumori, R | 1 |
| Minegishi, A | 1 |
| Satoh, T | 1 |
| Kitagawa, H | 1 |
| Michaelis, EK | 2 |
| Michaelis, ML | 1 |
| Freed, WJ | 2 |
| Kokka, N | 1 |
| Sapp, DW | 1 |
| Taylor, AM | 1 |
| Olsen, RW | 1 |
| Ibbotson, T | 1 |
| Field, MJ | 1 |
| Boden, PR | 1 |
| Buczek, Y | 1 |
| Lê, AD | 1 |
| Sellers, EM | 1 |
| Tomkins, DM | 1 |
| Pinel, JP | 1 |
| Van Oot, PH | 1 |
| Prather, PL | 1 |
| Lal, H | 1 |
| Kazamatsuri, H | 1 |
| Ratcliffe, F | 1 |
12 other studies available for pentylenetetrazole and Alcoholism
| Article | Year |
|---|---|
Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal.
Topics: Alcoholism; Animals; Anticonvulsants; Ethosuximide; Male; Mice; Mice, Inbred DBA; Mortality; Pentyle | 2015 |
Khat (Catha edulis) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model.
Topics: Alcoholism; Animals; Catha; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism | 2011 |
Changes in seizure susceptibility after successive treatments of mice with tryptophol and ethanol.
Topics: Alcoholism; Animals; Anticonvulsants; Brain; Brain Chemistry; Ethanol; Humans; Indoles; Male; Mice; | 1981 |
Chronic ethanol intake and synaptosomal glutamate binding activity.
Topics: Alcoholism; Animals; Brain; Calcium; Ethanol; Glutamates; Humans; Kainic Acid; Kinetics; Pentylenete | 1980 |
The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Dose-Response Relationship, Drug; Drug Tole | 1993 |
Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro.
Topics: Alcoholism; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Convulsants; Excitatory Postsy | 1997 |
Effect of pentylenetetrazole on ethanol intake, ethanol kinetics, and social behavior in male Wistar rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety; Arousal; Convulsants; Drug Tolerance; Ethanol; Male; | 1998 |
Glutamic acid and ethanol dependence.
Topics: Alcoholism; Animals; Brain Chemistry; Ethanol; Excitatory Amino Acid Antagonists; Glutamates; Humans | 1978 |
Generality of the kindling phenomenon: some clinical implications.
Topics: Alcoholism; Animals; Disease Models, Animal; Humans; Male; Pentylenetetrazole; Rats; Seizures; Subst | 1975 |
Protracted withdrawal: sensitization of the anxiogenic response to cocaine in rats concurrently treated with ethanol.
Topics: Alcoholism; Animals; Anxiety; Cocaine; Discrimination Learning; Discrimination, Psychological; Drug | 1992 |
EEG activation with Dimefline hydrochloride.
Topics: Adolescent; Adult; Alcoholism; Central Nervous System Stimulants; Craniocerebral Trauma; Electroence | 1969 |
Ethanol dependence in the rat: its production and characteristics.
Topics: Alcoholism; Animals; Auditory Threshold; Behavior, Animal; Electroshock; Ethanol; Female; Humans; Pe | 1972 |