pentylenetetrazole has been researched along with Alcohol Withdrawal Associated Autonomic Hyperactivity in 4 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Withdrawal Seizure-Prone (WSP) and -Resistant (WSR) mice, which were selectively bred for severe (WSP) or mild (WSR) handling-induced convulsions (HICs) following chronic ethanol inhalation, were found to differ in sensitivity to the anticonvulsant effects of the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one (3 alpha,5 alpha-P." | 1.29 | Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice. ( Crabbe, JC; Finn, DA; Roberts, AJ, 1995) |
| " The long-lasting decrease in seizure threshold following CIE treatment resembled the "kindling" phenomenon produced by chronic administration of PTZ (25 mg/kg, 3 times/week)." | 1.29 | The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol. ( Kokka, N; Olsen, RW; Sapp, DW; Taylor, AM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Finn, DA | 1 |
| Roberts, AJ | 1 |
| Crabbe, JC | 2 |
| Merrill, CM | 1 |
| Belknap, JK | 1 |
| Kokka, N | 1 |
| Sapp, DW | 1 |
| Taylor, AM | 1 |
| Olsen, RW | 1 |
| Gauvin, DV | 1 |
| Harland, RD | 1 |
| Criado, JR | 1 |
| Michaelis, RC | 1 |
| Holloway, FA | 1 |
4 other studies available for pentylenetetrazole and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Elec | 1995 |
Effect of acute alcohol withdrawal on sensitivity to pro- and anticonvulsant treatments in WSP mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Arousal; Convulsants; Diazepam; Dizocilpine M | 1993 |
The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Dose-Response Relationship, Drug; Drug Tole | 1993 |
The discriminative stimulus properties of ethanol and acute ethanol withdrawal states in rats.
Topics: Affect; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholic Intoxication; Animals; Arousal; Chl | 1989 |