pentylenetetrazole has been researched along with Aging in 97 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This work describes a novel epilepsy model, combining pentylenetetrazole (PTZ) kindling with the senescence-accelerated mouse P8 (SAMP8) a model for aging." | 7.71 | The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism. ( Bidar, A; Kondziella, D; Sletvold, O; Sonnewald, U; Urfjell, B, 2002) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 7.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| "The anticonvulsant action of NNC 711 [(1-(2-((diphenylmethylene) amino) oxy) ethyl)-1,2,4,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride], an inhibitor of the GABA transporter GAT-1, was studied in a model of pentylenetetrazol-induced motor seizures in rats 7, 12, 18, 25, and 90 days old." | 7.70 | Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. ( Haugvicová, R; Kubová, H; Mares, P, 1998) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "The effects of cinromide on two types of metrazol-induced seizures were studied in 236 male rats aged 7, 12, 18, 25 and 90 days." | 7.67 | Influence of cinromide on metrazol--induced seizures during ontogenesis in rats. ( Bernásková, K; Mares, P; Rokyta, R, 1988) |
| "An anticonvulsant action of ketamine, a noncompetitive NMDA receptor antagonist (1-40 mg/kg IP), on the metrazol-induced seizures was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.67 | Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. ( Blanková-Vanková, S; Mares, P; Mikolásová, R; Velísek, L, 1989) |
| "The incidence of seizures, their expression pattern and their latencies were registered and the severity was expressed by means of a five-point scale." | 5.39 | Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. ( Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B, 2013) |
| "Generalized tonic-clonic seizures were suppressed in all age groups, the three youngest groups being more sensitive than older animals." | 5.30 | The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Mikulecká, A, 1999) |
| "PCP injection had little effect on the seizure susceptibility of older rats." | 5.29 | Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures. ( Moshe, SL; Sircar, R; Veliskova, J, 1994) |
| "Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s." | 5.27 | Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats. ( Mares, P; Velísek, L, 1983) |
| "Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)." | 4.76 | Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984) |
| " In the present study, we induced lithium and pilocarpine status epilepticus (SE) in 10-day-old (P10) rats." | 3.71 | Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. ( Dubé, C; Koning, E; Nehlig, A, 2002) |
| "This work describes a novel epilepsy model, combining pentylenetetrazole (PTZ) kindling with the senescence-accelerated mouse P8 (SAMP8) a model for aging." | 3.71 | The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism. ( Bidar, A; Kondziella, D; Sletvold, O; Sonnewald, U; Urfjell, B, 2002) |
| "The present study was designed to evaluate the effects of age on the efficacy of the ketogenic diet in suppressing seizures evoked by tail-vein infusion of pentylenetetrazole (PTZ)." | 3.70 | Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. ( Bough, KJ; Eagles, DA; Han, FT; Valiyil, R, 1999) |
| " The intraperitoneal administration of pentylenetetrazole (PTZ) to rats of various ages evoked tonic-clonic seizures." | 3.70 | Delayed and blunted induction of mRNA for tissue plasminogen activator in the brain of old rats following pentylenetetrazole-induced seizure activity. ( Fischer, B; Kessler, C; Platt, D; Popa-Wagner, A; Schmoll, H, 2000) |
| "The anticonvulsant action of NNC 711 [(1-(2-((diphenylmethylene) amino) oxy) ethyl)-1,2,4,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride], an inhibitor of the GABA transporter GAT-1, was studied in a model of pentylenetetrazol-induced motor seizures in rats 7, 12, 18, 25, and 90 days old." | 3.70 | Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. ( Haugvicová, R; Kubová, H; Mares, P, 1998) |
| "Brain creatine kinase (CK) catalyzed phosphorus fluxes between phosphocreatine (PCr) and ATP and changes in reactant concentrations were measured using [31P] nuclear magnetic resonance spectroscopy ([31P]NMR) before and during pentylenetetrazole-induced seizures in 7 and 21 day old rats." | 3.69 | Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats. ( Holtzman, D; Jensen, F; Khait, I; Meyers, R, 1997) |
| "The action of progabide against motor seizures elicited by pentylenetetrazol was studied in 7-, 12-, 18-, 25-day-old and adult rats." | 3.69 | Anticonvulsant effect of progabide in rats during ontogenesis. ( Kozuchová, A; Mares, P; Stanková, L, 1997) |
| "The anticonvulsant actions of lamotrigine and phenytoin against pentylenetetrazol-induced seizures were compared in laboratory rats during ontogenesis." | 3.68 | Anticonvulsant action of lamotrigine during ontogenesis in rats. ( Kubová, H; Mares, P; Stanková, L, 1992) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "The influence of flumazenil on seizures induced by pentylenetetrazol (PTZ) was studied in rats aged 7, 12, 18, 25, and 90 days." | 3.68 | Anticonvulsant activity of flumazenil in rats during ontogenetic development. ( Kubová, H; Mares, P; Rathouská, J; Vorlícek, J, 1993) |
| "An anticonvulsant action of ketamine, a noncompetitive NMDA receptor antagonist (1-40 mg/kg IP), on the metrazol-induced seizures was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.67 | Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. ( Blanková-Vanková, S; Mares, P; Mikolásová, R; Velísek, L, 1989) |
| "The effects of cinromide on two types of metrazol-induced seizures were studied in 236 male rats aged 7, 12, 18, 25 and 90 days." | 3.67 | Influence of cinromide on metrazol--induced seizures during ontogenesis in rats. ( Bernásková, K; Mares, P; Rokyta, R, 1988) |
| "Hypoxia-induced neonatal seizure mainly leads to deleterious effects on brain function, especially cognitive impairments and increased susceptibility to epilepsy later in life." | 1.62 | FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation. ( Farbood, Y; Ghafouri, S; Najafian, SA; Sarkaki, A, 2021) |
| "Pretreatment with ifenprodil resulted in an anticonvulsant effect in 15-day-old rats only, on the contrary, proconvulsant action was found in 18- and 25-day-old animals (decrease of thresholds especially for transition into the second, limbic type of ADs and increase in duration of ADs)." | 1.40 | Age and activation determines the anticonvulsant effect of ifenprodil in rats. ( Mareš, P, 2014) |
| "The incidence of seizures, their expression pattern and their latencies were registered and the severity was expressed by means of a five-point scale." | 1.39 | Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. ( Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B, 2013) |
| "Caffeine treatment at a daily dose of 10 and/or 20 mg/kg, sc was executed during postnatal days 7-11." | 1.39 | Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. ( Kubová, H; Mareš, P; Tchekalarova, JD, 2013) |
| "However, the effect of stress on the convulsion in juvenile animals has been rarely investigated." | 1.38 | Involvement of dopaminergic system in stress-induced anticonvulsant effect in juvenile mice. ( Abe, K; Hiroyama, S; Horiuchi, M; Itoh, T, 2012) |
| "The incidence of spontaneous seizures has been reported to be increased in sporadic AD as well as in the early onset autosomal dominant forms of AD." | 1.38 | Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. ( Bales, K; Cirrito, JR; Delong, C; Holtzman, DM; Hunter, JM; Kinley, RD; Koger, D; Lin, S; Liu, F; Paul, SM; Restivo, JL; Sullivan, PM; Zhao, L, 2012) |
| "Seizures were induced 30 min later using a chemoconvulsant (pentylenetetrazol, PTZ) model, which has been widely used to determine anticonvulsant efficacy of many other antiepileptic drugs in neonatal animals." | 1.38 | Anticonvulsant effect of retigabine during postnatal development in rats. ( Forcelli, PA; Gale, K; Kondratyev, A; Lakhkar, A; Soper, C, 2012) |
| "Epilepsy is a chronic neurological disorder and well documented to induce cognitive impairment." | 1.38 | Age dependent learning and memory deficit in Pentylenetetrazol kindled mice. ( Goel, RK; Mishra, A, 2012) |
| "The effect of zolpidem against tonic seizures was greater than against two other seizure components and death." | 1.36 | Zolpidem is a potent anticonvulsant in adult and aged mice. ( Pericić, D; Vlainić, J, 2010) |
| "Palmitone is a secondary metabolite of polyketide origin extracted from leaves of Annona diversifolia Saff." | 1.36 | Palmitone prevents pentylenetetrazole-caused neuronal damage in the CA3 hippocampal region of prepubertal rats. ( Blas-Valdivia, V; Cano-Europa, E; González-Trujano, ME; Hernández-García, A; Ortiz-Butrón, R; Reyes-Ramírez, A, 2010) |
| "Bumetanide is a specific inhibitor of this cotransporter." | 1.35 | Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009) |
| "The effects of chronic administration of pentylenetetrazole (PTZ) during early ontogenesis (from postnatal day 14) on the dynamics of age-related changes in electrophysiological characteristics of rat hippocampal slices were studied." | 1.34 | Kindling in the early postnatal period: Effects on the dynamics of age-related changes in electrophysiological characteristics of hippocampal neurons. ( Egorova, LK; Gulyaeva, NV; Kudryashov, IE; Kudryashova, IV; Pavlova, TV, 2007) |
| "From that age onwards, the seizure threshold significantly decreased and reached a minimum at PN 220." | 1.31 | PTZ-induced seizures in rats: effects of age and strain. ( Chepurnov, SA; Chepurnova, NE; Klioueva, IA; van Luijtelaar, EL, 2001) |
| "Hippocampal area was unaffected." | 1.30 | Dextromethorphan ameliorates effects of neonatal hypoxia on brain morphology and seizure threshold in rats. ( Baggs, R; Guillet, R; Laroia, N; McBride, L, 1997) |
| "Results indicate that seizure threshold was significantly elevated with increasing ketogenic ratios (i." | 1.30 | Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat. ( Bough, KJ; Chen, RS; Eagles, DA, 1999) |
| "Pentylenetetrazole treatment in young rats resulted in a robust induction of microtubule-associated protein 1B immunoreactivity in the granule cells of the dentate gyrus and in layers II/III of the entorhinal cortex, but also produced a large decrease in the retrosplenial cortex." | 1.30 | Anomalous expression of microtubule-associated protein 1B in the hippocampus and cortex of aged rats treated with pentylenetetrazole. ( Fischer, B; Kessler, C; Neubig, R; Platt, D; Popa-Wagner, A; Schmoll, H, 1999) |
| "Generalized tonic-clonic seizures were suppressed in all age groups, the three youngest groups being more sensitive than older animals." | 1.30 | The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Mikulecká, A, 1999) |
| "At P21, l-Arg improved the outcome of seizures while LNA had no effect." | 1.30 | Age-dependent regulation of seizure activity by nitric oxide in the developing rat. ( Marescaux, C; Nehlig, A; Pereira de Vasconcelos, A, 1998) |
| " We demonstrate that jerky has a dosage-sensitive function (haploinsufficiency) in brain and that this sensitivity to reduced jerky dosage could explain the occurrence of seizures in hemizygotes." | 1.30 | Sensitivity to jerky gene dosage underlies epileptic seizures in mice. ( Donovan, GP; Gal, J; Gudas, LJ; Harden, C; Ho, L; Sibille, E; Toth, M; Trifiletti, R, 1997) |
| "SL 75 102 suppressed generalized tonic-clonic seizures in adult rats and restricted the tonic phase of these seizures in rat pups." | 1.30 | Anticonvulsant effect of SL 75 102 in adult and immature rats. ( Haugvicová, R; Kubová, H; Mares, P, 1997) |
| "Seizures were induced by repetitive injections of subconvulsive doses of PTZ." | 1.30 | Mapping of neuronal networks underlying generalized seizures induced by increasing doses of pentylenetetrazol in the immature and adult rat: a c-Fos immunohistochemical study. ( André, V; Marescaux, C; Motte, JE; Nehlig, A; Pineau, N, 1998) |
| "The effect of a single neonatal convulsion on subsequent behaviour was investigated in the male rat." | 1.29 | The effects of a single neonatally induced convulsion on spatial navigation, locomotor activity and convulsion susceptibility in the adult rat. ( Boon, F; Cain, DP; Kornelsen, RA; Leung, LS, 1996) |
| "After PTZ or flurothyl seizures, both ages exhibited similar patterns of IR in amygdala, pyriform cortex, and hypothalamus." | 1.29 | Differences in c-fos immunoreactivity due to age and mode of seizure induction. ( Firkusny, IR; Jensen, FE; Mower, GD, 1993) |
| "A single seizure was induced by pentylenetetrazol (PTZ; 150 mg/kg i." | 1.29 | Persistent physiological effects caused by a single pentylenetetrazol induced seizure in neonatal rats. ( Boon, F; Cain, DP; Leung, LS; Zhao, D, 1994) |
| "PCP injection had little effect on the seizure susceptibility of older rats." | 1.29 | Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures. ( Moshe, SL; Sircar, R; Veliskova, J, 1994) |
| "Ontogenetic differences in seizure thresholds to pentylenetetrazol (PTZ) were examined in young, developing rats (ages: 10, 18, 28, and 60 days)." | 1.29 | Ontogenetic development and pentylenetetrazol seizure thresholds in rats. ( Mostofsky, DI; Weller, A, 1995) |
| "At P14, LC was not affected by seizures." | 1.28 | An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. I. Behavioral characterization and determination of lumped constant. ( de Vasconcelos, AP; el Hamdi, G; Nehlig, A; Vert, P, 1992) |
| "A quantitative description of motor seizures induced by pentylenetetrazol (PTZ, metrazol) was performed." | 1.28 | Pentylenetetrazol-induced seizures in rats: an ontogenetic study. ( Kubova, H; Mares, P; Pohl, M; Schickerova, R; Stankova, L; Velisek, L, 1992) |
| "The incidence and latency of minimal seizures (pure clonic without the loss of righting ability) and of generalized tonic-clonic seizures (major) were evaluated and compared with the control groups." | 1.28 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. ( Kulovaná, M; Kusá, R; Mares, P; Velísek, L, 1990) |
| "Evans blue was used as a visual indicator of BBB integrity." | 1.28 | Age-related changes in regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by pentylenetetrazol. ( Ates, N; Ziylan, YZ, 1989) |
| "Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s." | 1.27 | Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats. ( Mares, P; Velísek, L, 1983) |
| "Similar action on minimal metrazol seizures (mMS) was present in rats aged 18 days and more." | 1.27 | Anti-metrazol action of R 57720 during postnatal development in rats. ( Lanstiaková, M; Mares, P; Pohl, M, 1988) |
| "The thresholds for inducing the maximal seizure by pentylenetetrazole (PTZ) were compared for BDF1 mice of both sexes with varying ages after intraperitoneal administration of various doses of PTZ." | 1.27 | Age-dependent increase in the threshold for pentylenetetrazole induced maximal seizure in mice. ( Kanai, S; Kitani, K; Masuda, Y; Nokubo, M; Ohta, M; Sato, Y, 1986) |
| "In 4- and 5-day-old rats, generalized seizures were manifested as slow waves only." | 1.26 | Electrocorticographic activity elicited by metrazol during ontogenesis in rats. ( Brozek, G; Mares, P; Zouhar, A, 1980) |
| "The pentylenetetrazole and peptide treatments also improved reversal learning." | 1.26 | Brain aging correlates: retardation by hormonal-pharmacological treatments. ( Baskin, RK; Landfield, PW; Pitler, TA, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (38.14) | 18.7374 |
| 1990's | 39 (40.21) | 18.2507 |
| 2000's | 11 (11.34) | 29.6817 |
| 2010's | 9 (9.28) | 24.3611 |
| 2020's | 1 (1.03) | 2.80 |
| Authors | Studies |
|---|---|
| Najafian, SA | 1 |
| Farbood, Y | 1 |
| Sarkaki, A | 1 |
| Ghafouri, S | 1 |
| Mareš, P | 32 |
| Kubová, H | 11 |
| Hen, N | 1 |
| Yagen, B | 1 |
| Bialer, M | 1 |
| Tchekalarova, JD | 1 |
| Vlainić, J | 1 |
| Pericić, D | 1 |
| Cano-Europa, E | 1 |
| González-Trujano, ME | 1 |
| Reyes-Ramírez, A | 1 |
| Hernández-García, A | 1 |
| Blas-Valdivia, V | 1 |
| Ortiz-Butrón, R | 1 |
| Mishra, A | 1 |
| Goel, RK | 1 |
| Forcelli, PA | 1 |
| Soper, C | 1 |
| Lakhkar, A | 1 |
| Gale, K | 1 |
| Kondratyev, A | 1 |
| Hunter, JM | 1 |
| Cirrito, JR | 1 |
| Restivo, JL | 1 |
| Kinley, RD | 1 |
| Sullivan, PM | 1 |
| Holtzman, DM | 1 |
| Koger, D | 1 |
| Delong, C | 1 |
| Lin, S | 1 |
| Zhao, L | 1 |
| Liu, F | 1 |
| Bales, K | 1 |
| Paul, SM | 1 |
| Hiroyama, S | 1 |
| Horiuchi, M | 1 |
| Abe, K | 1 |
| Itoh, T | 1 |
| Nehlig, A | 6 |
| Dubé, C | 1 |
| Koning, E | 1 |
| ANDOSCA, JB | 1 |
| CALLAN, JR | 1 |
| STARNES, WL | 1 |
| SUTER, WB | 1 |
| FISHER, J | 1 |
| FRIEDLANDER, WJ | 1 |
| THEOPOLD, W | 1 |
| FORSTER, E | 1 |
| KAPERNICK, JS | 1 |
| CADILHAC, J | 1 |
| PASSOUANT-FONTAINE, T | 1 |
| MIHAILOVIC, J | 1 |
| Mikulecká, A | 2 |
| Kudryashov, IE | 1 |
| Pavlova, TV | 1 |
| Kudryashova, IV | 1 |
| Egorova, LK | 1 |
| Gulyaeva, NV | 1 |
| Vernadakis, A | 1 |
| Timiras, PS | 1 |
| Landfield, PW | 1 |
| Baskin, RK | 1 |
| Pitler, TA | 1 |
| Lippa, AS | 1 |
| Meyerson, LR | 1 |
| Beer, B | 1 |
| Abbracchio, MP | 1 |
| Balduini, W | 1 |
| Coen, E | 1 |
| Lombardelli, G | 1 |
| Peruzzi, G | 1 |
| Cattabeni, F | 1 |
| Goodnick, P | 1 |
| Gershon, S | 1 |
| Zouhar, A | 2 |
| Brozek, G | 2 |
| Velísek, L | 8 |
| Hlavatá, J | 1 |
| Lisková, K | 1 |
| Mudrochová, M | 1 |
| Vachová, D | 1 |
| Hussenet, F | 1 |
| Boyet, S | 1 |
| Weller, A | 1 |
| Mostofsky, DI | 1 |
| Sircar, R | 1 |
| Veliskova, J | 2 |
| Moshe, SL | 1 |
| Zhao, D | 1 |
| Leung, LS | 2 |
| Boon, F | 2 |
| Cain, DP | 2 |
| Seidl, J | 1 |
| Nováková, J | 1 |
| Kaminska, B | 1 |
| Kaczmarek, L | 2 |
| Rathouská, J | 1 |
| Vorlícek, J | 1 |
| Jensen, FE | 1 |
| Firkusny, IR | 1 |
| Mower, GD | 1 |
| Kornelsen, RA | 1 |
| Grecksch, G | 1 |
| Becker, A | 1 |
| Rauca, C | 1 |
| Holtzman, D | 1 |
| Meyers, R | 1 |
| Khait, I | 1 |
| Jensen, F | 1 |
| Donovan, GP | 1 |
| Harden, C | 1 |
| Gal, J | 1 |
| Ho, L | 1 |
| Sibille, E | 1 |
| Trifiletti, R | 1 |
| Gudas, LJ | 1 |
| Toth, M | 1 |
| Laroia, N | 1 |
| McBride, L | 1 |
| Baggs, R | 1 |
| Guillet, R | 1 |
| Tsuda, M | 1 |
| Suzuki, T | 1 |
| Misawa, M | 1 |
| Pereira de Vasconcelos, A | 2 |
| Marescaux, C | 2 |
| da Silva, LF | 1 |
| Pereira, P | 1 |
| Elisabetsky, E | 1 |
| Haugvicová, R | 4 |
| Stanková, L | 4 |
| Kozuchová, A | 1 |
| André, V | 1 |
| Pineau, N | 1 |
| Motte, JE | 1 |
| Bough, KJ | 2 |
| Valiyil, R | 1 |
| Han, FT | 1 |
| Eagles, DA | 2 |
| Górecki, DC | 1 |
| Szklarczyk, A | 1 |
| Lukasiuk, K | 1 |
| Simons, JP | 1 |
| Chen, RS | 1 |
| Popa-Wagner, A | 2 |
| Fischer, B | 2 |
| Platt, D | 3 |
| Neubig, R | 1 |
| Schmoll, H | 3 |
| Kessler, C | 3 |
| Wagner, AP | 1 |
| Badan, I | 1 |
| Bazyan, AS | 1 |
| Zhulin, VV | 1 |
| Karpova, MN | 1 |
| Klishina, NY | 1 |
| Glebov, RN | 1 |
| Klioueva, IA | 1 |
| van Luijtelaar, EL | 1 |
| Chepurnova, NE | 1 |
| Chepurnov, SA | 1 |
| Kondziella, D | 1 |
| Bidar, A | 1 |
| Urfjell, B | 1 |
| Sletvold, O | 1 |
| Sonnewald, U | 1 |
| Bartus, RT | 1 |
| Paoletti, R | 1 |
| Folco, GC | 1 |
| Spagnuolo, C | 1 |
| Terzi, C | 1 |
| Consroe, P | 1 |
| Picchioni, A | 1 |
| Chin, L | 1 |
| Ryan, LJ | 1 |
| Sharpless, SK | 1 |
| Ghosh, S | 1 |
| Maiti, AK | 1 |
| Chiba, S | 1 |
| Muneoka, Y | 1 |
| Sato, Y | 3 |
| Miyagishi, T | 1 |
| el Hamdi, G | 2 |
| de Vasconcelos, AP | 1 |
| Vert, P | 2 |
| Pohl, M | 3 |
| Schickerova, R | 1 |
| Ziylan, YZ | 2 |
| Lefauconnier, JM | 1 |
| Ates, N | 2 |
| Bernard, G | 1 |
| Bourre, JM | 1 |
| Jänicke, B | 1 |
| Coper, H | 1 |
| Veresová, S | 1 |
| Pôbisová, H | 1 |
| Rokyta, R | 2 |
| Kusá, R | 1 |
| Kulovaná, M | 1 |
| Maresová, S | 1 |
| Maresová, D | 1 |
| Mikolásová, R | 1 |
| Blanková-Vanková, S | 1 |
| Lanstiaková, M | 1 |
| Bernásková, K | 1 |
| Kitani, K | 3 |
| Kanai, S | 2 |
| Ohta, M | 2 |
| Nokubo, M | 3 |
| Masuda, Y | 2 |
| Masserini, C | 1 |
| Rosina, E | 1 |
| Morosini, F | 1 |
| Altamura, AC | 1 |
| Cazzullo, CL | 1 |
| Torcello, L | 1 |
| Stein, DG | 1 |
| Schlesinger, K | 1 |
| Uphouse, LL | 1 |
| Gaetti, R | 1 |
| Frolkis, VV | 1 |
| Bezrukov, VV | 1 |
| Sinitsky, VN | 1 |
| Stoller, W | 1 |
4 reviews available for pentylenetetrazole and Aging
| Article | Year |
|---|---|
Molecular substrates of anxiety: clues from the heterogeneity of benzodiazepine receptors.
Topics: Aging; Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Chemical Phenomen | 1982 |
Chemotherapy of cognitive disorders in geriatric subjects.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co | 1984 |
Audiogenic seizure susceptible rats.
Topics: Acoustic Stimulation; Aging; Aluminum Hydroxide; Animals; Anticonvulsants; Behavior, Animal; Brain; | 1979 |
Pyridoxine dependency and central nervous system excitability.
Topics: Acoustic Stimulation; Aging; Aminobutyrates; Animals; Brain Chemistry; Drug Interactions; Electric S | 1972 |
93 other studies available for pentylenetetrazole and Aging
| Article | Year |
|---|---|
FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation.
Topics: Aging; Animals; Animals, Newborn; Cognitive Dysfunction; Epilepsy; Female; Fingolimod Hydrochloride; | 2021 |
Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats.
Topics: Aging; Allylisopropylacetamide; Amides; Animals; Anticonvulsants; Convulsants; Epilepsy, Generalized | 2013 |
Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
Topics: Aging; Animals; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Myoc | 2013 |
Age and activation determines the anticonvulsant effect of ifenprodil in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Electric Stimulation; Male; Pentylenetetrazole; P | 2014 |
Age-dependent anticonvulsant action of antagonists of group I glutamate metabotropic receptors in rats.
Topics: Aging; Analysis of Variance; Animal Diseases; Animals; Animals, Newborn; Anticonvulsants; Dicarboxyl | 2009 |
AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Benzhydryl Compounds; Disease Models, Animal; Dose-Res | 2008 |
Zolpidem is a potent anticonvulsant in adult and aged mice.
Topics: Age Factors; Aging; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interact | 2010 |
Palmitone prevents pentylenetetrazole-caused neuronal damage in the CA3 hippocampal region of prepubertal rats.
Topics: Aging; Animals; CA3 Region, Hippocampal; Cell Count; Convulsants; Hydrocarbons; Ketones; Neurons; Ne | 2010 |
Age- and dose-specific anticonvulsant action of bumetanide in immature rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Dose-Response Rela | 2009 |
Age dependent learning and memory deficit in Pentylenetetrazol kindled mice.
Topics: Aging; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Feasibility Studies; Learning; M | 2012 |
Anticonvulsant effect of retigabine during postnatal development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Convulsants; Dose-Response Relationsh | 2012 |
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
Topics: Aging; Amyloid beta-Peptides; Animals; Apolipoprotein E4; Behavior, Animal; Biomarkers; Body Weight; | 2012 |
Involvement of dopaminergic system in stress-induced anticonvulsant effect in juvenile mice.
Topics: Aging; Animals; Brain; Convulsants; Dopamine; Mice; Microdialysis; Norepinephrine; Pentylenetetrazol | 2012 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; | 2002 |
Effects of pentylenetrazol on senile patients; a clinical study.
Topics: Aged; Aging; Biomedical Research; Humans; Patients; Pentylenetetrazole | 1954 |
Analeptic action of oral metrazol in geriatric practice; a preliminary report.
Topics: Aged; Aging; Central Nervous System Stimulants; Humans; Pentylenetetrazole | 1954 |
Oral metrazol therapy in senility; a preliminary report.
Topics: Aging; Dementia; Mental Disorders; Pentylenetetrazole; Psychotic Disorders | 1955 |
The relation of age to metrazol-activated EEGs.
Topics: Aging; Electroencephalography; Humans; Pentylenetetrazole | 1955 |
[Spasmophilia and age; studies on cardiazol convulsive threshold in rabbits].
Topics: Aging; Animals; Humans; Lagomorpha; Pentylenetetrazole; Rabbits; Seizures; Tetany | 1956 |
Metrazol for central nervous system arteriosclerosis in aging patients.
Topics: Aging; Arteriosclerosis; Central Nervous System; Central Nervous System Diseases; Pentylenetetrazole | 1957 |
[Modification according to age, from 0 to 45 days, of cortical, hippocampal, thalamic and reticular after-discharges as well as cardiazolic crises in the kitten].
Topics: Aging; Animals; Cats; Electroencephalography; Female; Hippocampus; Pentylenetetrazole; Thalamus | 1960 |
MPEP, an antagonist of metabotropic glutamate receptors, exhibits anticonvulsant action in immature rats without a serious impairment of motor performance.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Ep | 2004 |
Kindling in the early postnatal period: Effects on the dynamics of age-related changes in electrophysiological characteristics of hippocampal neurons.
Topics: Aging; Animals; Animals, Newborn; Convulsants; Data Interpretation, Statistical; Electrophysiology; | 2007 |
Interrelation between convulsant drugs and x-irradiation on the central nervous system of rats.
Topics: Aging; Animals; Animals, Newborn; Central Nervous System; Male; Pentylenetetrazole; Radiation Effect | 1967 |
Brain aging correlates: retardation by hormonal-pharmacological treatments.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aging; Animals; Brain; Hippocampus; Learning; Pentylenet | 1981 |
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid; | 1983 |
The electrocorticographic pattern of generalized seizures in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Dominance, Cerebral; Electroencephalography; Evoked Potentials; Mal | 1980 |
Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Ethosuximide; Male; Pentylenetetrazole; Rats; Rats | 1983 |
Effects of carbamazepine and diphenylhydantoin on metrazol seizures during ontogenesis in rats.
Topics: Aging; Animals; Carbamazepine; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seiz | 1983 |
Electrocorticographic activity elicited by metrazol during ontogenesis in rats.
Topics: Aging; Animals; Electroencephalography; Male; Pentylenetetrazole; Rats; Seizures | 1980 |
Kainate/AMPA receptor antagonists are anticonvulsant against the tonic hindlimb component of pentylenetetrazol-induced seizures in developing rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Anticonvulsants; Behavior, Animal; Epilepsy, T | 1995 |
Long-term metabolic effects of pentylenetetrazol-induced status epilepticus in the immature rat.
Topics: Aging; Animals; Blood Glucose; Brain Chemistry; Female; Glucose; Hemodynamics; Male; Pentylenetetraz | 1995 |
Ontogenetic development and pentylenetetrazol seizure thresholds in rats.
Topics: Aging; Animals; Behavior, Animal; Epilepsy, Tonic-Clonic; Female; Male; Pentylenetetrazole; Rats; Ra | 1995 |
Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Pentylenetetrazole; Phencyclidine; Rats; Rats, Sp | 1994 |
Persistent physiological effects caused by a single pentylenetetrazol induced seizure in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Electrodes, Implanted; Evoked Potentials; Hippocampus; In Vitro Te | 1994 |
Differential action of phenytoin and carbamazepine on cortical interhemispheric responses in young but not in adult rats.
Topics: Aging; Analysis of Variance; Animals; Carbamazepine; Electric Stimulation; Epilepsy, Tonic-Clonic; M | 1993 |
Robust induction of AP-1 transcription factor DNA binding activity in the hippocampus of aged rats.
Topics: Aging; Animals; Base Sequence; Brain Chemistry; DNA; Electrophoresis, Polyacrylamide Gel; Gene Expre | 1993 |
Anticonvulsant activity of flumazenil in rats during ontogenetic development.
Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; F | 1993 |
Differences in c-fos immunoreactivity due to age and mode of seizure induction.
Topics: Aging; Animals; Flurothyl; Hypoxia; Immunohistochemistry; Pentylenetetrazole; Proto-Oncogene Protein | 1993 |
The effects of a single neonatally induced convulsion on spatial navigation, locomotor activity and convulsion susceptibility in the adult rat.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Disease Susceptibility; Hot Temperature; Mal | 1996 |
Effect of age on pentylenetetrazol-kindling and kindling-induced impairments of learning performance.
Topics: Aging; Animals; Avoidance Learning; Brain Chemistry; Convulsants; Kindling, Neurologic; Male; Pentyl | 1997 |
Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats.
Topics: Adenosine Triphosphate; Aging; Animals; Brain; Brain Chemistry; Creatine Kinase; Electroencephalogra | 1997 |
Sensitivity to jerky gene dosage underlies epileptic seizures in mice.
Topics: Aging; Alleles; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; Disease Susceptibility; DNA Pr | 1997 |
Dextromethorphan ameliorates effects of neonatal hypoxia on brain morphology and seizure threshold in rats.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Brain; Cerebral Cortex; | 1997 |
Age-related decrease in the antiseizure effect of ifenprodil against pentylenetetrazole in mice.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists | 1997 |
Age-dependent regulation of seizure activity by nitric oxide in the developing rat.
Topics: Aging; Animals; Enzyme Inhibitors; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pentylenetetr | 1998 |
A neuropharmacological analysis of PTZ-induced kindling in mice.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Diazepam; Glutamic Acid; Kindling, Neurologic; Male; M | 1998 |
Qualitative changes of anticonvulsant action of felbamate during development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Fe | 1998 |
Anticonvulsant effect of progabide in rats during ontogenesis.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Convulsants; gamma-Aminobutyric Acid; Male; Penty | 1997 |
Anticonvulsant effect of SL 75 102 in adult and immature rats.
Topics: Aging; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Pentylenetetrazole; Rats; Seizures | 1997 |
Mapping of neuronal networks underlying generalized seizures induced by increasing doses of pentylenetetrazol in the immature and adult rat: a c-Fos immunohistochemical study.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Electroencepha | 1998 |
Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroencephalograp | 1998 |
Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Behavior, Animal; Convulsants; Diet; Energy Intake; Growth; K | 1999 |
Differential seizure-induced and developmental changes of neurexin expression.
Topics: Aging; Animals; Animals, Newborn; Gene Expression; Isomerism; Kainic Acid; Male; Nerve Tissue Protei | 1999 |
Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Body Weight; Convulsants; Diet; Differential Threshold; Disea | 1999 |
Anomalous expression of microtubule-associated protein 1B in the hippocampus and cortex of aged rats treated with pentylenetetrazole.
Topics: Aging; Animals; Blotting, Northern; Cerebral Cortex; Female; Gene Expression Regulation, Development | 1999 |
The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; GABA-A Receptor Anta | 1999 |
Delayed and blunted induction of mRNA for tissue plasminogen activator in the brain of old rats following pentylenetetrazole-induced seizure activity.
Topics: Aging; Analysis of Variance; Animals; Blotting, Northern; Brain; Enzyme Induction; Female; Gene Expr | 2000 |
Brain plasticity: to what extent do aged animals retain the capacity to coordinate gene activity in response to acute challenges.
Topics: Aging; Animals; Brain; Gene Expression Regulation, Developmental; Hippocampus; Immunohistochemistry; | 2000 |
Long-term reduction of benzodiazepine receptor density in the rat cerebellum by acute seizures and kindling and its recovery 6 months later by a pentylenetetrazole challenge.
Topics: Acute Disease; Aging; Animals; Cerebellum; Convulsants; Diazepam; Drug Administration Schedule; Epil | 2001 |
PTZ-induced seizures in rats: effects of age and strain.
Topics: Aging; Animals; Brain; Convulsants; Epilepsy, Tonic-Clonic; Male; Pentylenetetrazole; Rats; Rats, Wi | 2001 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism.
Topics: Aging; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Epilepsy; Excita | 2002 |
Four stimulants of the central nervous system: effects on short-term memory in young versus aged monkeys.
Topics: Aging; Animals; Caffeine; Central Nervous System Stimulants; Female; Haplorhini; Macaca mulatta; Mal | 1979 |
Relationship between the prostaglandin system and responsiveness to epileptogenic agents in mature and immature rats.
Topics: Aging; Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic GMP; Harmaline; Pentylenetetrazole; Pros | 1978 |
Genetically determined spontaneous and pentylenetetrazol-induced brief spindle episodes in mice.
Topics: Aging; Animals; Brain; Electroencephalography; Female; Genes; Male; Mice; Mice, Inbred BALB C; Mice, | 1979 |
Seizure susceptibility & convulsibility in neonate chicks.
Topics: Aging; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Male; Penicillins; Penty | 1979 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
[Seizure susceptibility in aged rats--pentylenetetrazol-induced seizures and amygdaloid kindling seizures].
Topics: Aging; Amygdala; Animals; Disease Susceptibility; Kindling, Neurologic; Male; Pentylenetetrazole; Ra | 1992 |
An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. I. Behavioral characterization and determination of lumped constant.
Topics: Aging; Animals; Blood Glucose; Brain; Disease Models, Animal; Female; Glucose; Kinetics; Lactates; M | 1992 |
An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. II. Mapping of brain metabolism using the quantitative [14C]2-deoxyglucose technique.
Topics: Aging; Animals; Autoradiography; Blood Glucose; Brain; Brain Mapping; Carbon Radioisotopes; Deoxyglu | 1992 |
Pentylenetetrazol-induced seizures in rats: an ontogenetic study.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Injections, Subcutaneous; | 1992 |
Anticonvulsant action of lamotrigine during ontogenesis in rats.
Topics: Aging; Animals; Anticonvulsants; Epilepsy, Tonic-Clonic; Injections, Intraperitoneal; Lamotrigine; M | 1992 |
Age-dependent alteration in regional cerebrovascular permeability during drug-induced epilepsy.
Topics: Aging; Animals; Blood-Brain Barrier; Capillary Permeability; Cerebrovascular Circulation; Epilepsy; | 1992 |
Anticonvulsant effects of benzodiazepine Ro 16-6028 during ontogenesis in the rat.
Topics: Aging; Animals; Anticonvulsants; Benzodiazepinones; Pentylenetetrazole; Rats; Receptors, GABA-A | 1991 |
Effects of age and drugs on food and fluid intake.
Topics: Aging; Amphetamines; Animals; Behavior, Animal; Benzodiazepines; Body Weight; Diazepam; Drinking; Dr | 1991 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. II. The effects of MK-801.
Topics: Aging; Amino Acids; Animals; Dizocilpine Maleate; Epilepsies, Myoclonic; Male; Pentylenetetrazole; P | 1991 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inb | 1990 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate.
Topics: 2-Amino-5-phosphonovalerate; Aging; Amino Acids; Animals; Anticonvulsants; Male; Motor Activity; Pen | 1990 |
Antimetrazol action and plasma levels of valproate in developing rats.
Topics: Aging; Animals; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valpro | 1989 |
Effects of ketamine on metrazol-induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Behavior, Animal; Ketamine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Re | 1989 |
Age-related changes in regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by pentylenetetrazol.
Topics: Aging; Animals; Blood Pressure; Blood-Brain Barrier; Cell Membrane Permeability; Epilepsy; Evans Blu | 1989 |
Anti-metrazol action of R 57720 during postnatal development in rats.
Topics: Aging; Animals; Anticonvulsants; Imidazoles; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; S | 1988 |
Influence of cinromide on metrazol--induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Anticonvulsants; Cinnamates; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; S | 1988 |
The neurotoxicity of phenobarbital and its effect in preventing pentylenetetrazole-induced maximal seizure in aging mice.
Topics: Administration, Oral; Aging; Animals; Drug Tolerance; Female; Injections, Intraperitoneal; Mice; Pen | 1988 |
Age-dependent decrease in the lethal threshold of pentylenetetrazole in mice.
Topics: Aging; Animals; Brain; Female; Male; Mice; Pentylenetetrazole; Respiratory Insufficiency; Seizures; | 1988 |
Effects of flunarizine on Metrazol-induced seizures in developing rats.
Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Flunarizine; Male; Pentylenetetra | 1987 |
Influence of clonazepam on electrocorticographic changes induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Clonazepam; Electrodes, Implanted; Electroencephalography; Male; Pentylenetetrazole; | 1987 |
Age-dependent increase in the threshold for pentylenetetrazole induced maximal seizure in mice.
Topics: Aging; Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Female; Male; Mice; Pentyle | 1986 |
Hyperbaric oxygen induced experimental epilepsy: the age factor.
Topics: Aging; Animals; Disease Models, Animal; Epilepsy; Hyperbaric Oxygenation; Male; Mice; Mice, Inbred S | 1986 |
The effects of early saline injections and pentylenetetrazol on Hebb-Williams maze performance in the adult rat.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Child; Discrimination Learning; Humans; Injectio | 1974 |
[Clinical experience with Cardiazol-Paracodin in bronchopathies of aged persons].
Topics: Acute Disease; Aged; Aging; Bronchitis; Chronic Disease; Cough; Drug Combinations; Humans; Laryngiti | 1972 |
Sensitivity of central nervous structures to humoral factors in aging.
Topics: Acetylcholine; Aging; Animals; Brain; Camphor; Electroencephalography; Electrophysiology; Epinephrin | 1972 |
Brain RNA hydrogen bonding in young and old rats after metrazol-induced convulsion.
Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Chemical Phenomena; Chemistry; Formaldehyde; Hydr | 1970 |