pentylenetetrazole has been researched along with Aggression in 47 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior." | 5.27 | Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984) |
| "Sodium phenobarbitone (20 and 70 mg/kg) had a significant anticonvulsant action against pentylenetetrazole-induced seizures, which persisted for 21 days of treatment." | 3.68 | Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal. ( File, SE; Wilks, LJ, 1990) |
| " In line with this hypothesis, it was found that three functional benzodiazepine antagonists (FG 7142, pentylenetetrazol, caffeine) decreased food intake, lowered aggression and strengthened freezing in lactating mother rats." | 3.67 | Behavioural similarities between mother rats and benzodiazepine-treated non-maternal animals. ( Ferreira, A; Hansen, S; Selart, ME, 1985) |
| "This study investigated the effects of acute and chronic caffeine treatment on behavior in the social interaction, holeboard and home-cage aggression tests and on proconvulsant actions with pentylenetetrazol." | 3.67 | Behavioral effects of acute and chronic administration of caffeine in the rat. ( Baldwin, HA; File, SE; Johnston, AL; Wilks, LJ, 1988) |
| " The anticonflict effect of brotizolam in rats was approximately as potent as that of diazepam and was augmented following chronic administration for 10 days." | 1.27 | Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative. ( Shibata, K; Shibata, S; Ueki, S; Watanabe, S; Yamamoto, T, 1984) |
| "Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior." | 1.27 | Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984) |
| "A residual effect of DPA against seizures induced by pentetrazole was shown, i." | 1.26 | Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment. ( Ciesielski, L; Klein, M; Mandel, P; Simler, S, 1982) |
| "Ptosis and catalepsy induced at these doses." | 1.25 | [Effect of beta-phenylethylamine derivatives on the central nervous system. II. Pharmacological effect of the intracerebral administration of metaraminol on the central nervous system]. ( Kisara, K; Sakurada, S; Shoji, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (85.11) | 18.7374 |
| 1990's | 5 (10.64) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (4.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Canzian, J | 1 |
| Fontana, BD | 1 |
| Quadros, VA | 1 |
| Müller, TE | 1 |
| Duarte, T | 1 |
| Rosemberg, DB | 1 |
| Becker, JA | 1 |
| Clesse, D | 1 |
| Spiegelhalter, C | 1 |
| Schwab, Y | 1 |
| Le Merrer, J | 1 |
| Kieffer, BL | 1 |
| BOURGAULT, PC | 1 |
| KARCZMAR, AG | 1 |
| SCUDDER, CL | 1 |
| Ueki, S | 1 |
| Watanabe, S | 1 |
| Yamamoto, T | 1 |
| Shibata, S | 1 |
| Shibata, K | 1 |
| Post, RM | 1 |
| Kennedy, C | 1 |
| Shinohara, M | 1 |
| Squillace, K | 1 |
| Miyaoka, M | 1 |
| Suda, S | 1 |
| Ingvar, DH | 1 |
| Sokoloff, L | 1 |
| Beltcheva, I | 1 |
| Stoytchev, T | 1 |
| Simler, S | 1 |
| Ciesielski, L | 1 |
| Klein, M | 1 |
| Mandel, P | 1 |
| Polc, P | 1 |
| Bonetti, EP | 1 |
| Pieri, L | 1 |
| Cumin, R | 1 |
| Angioi, RM | 1 |
| Möhler, H | 1 |
| Haefely, WE | 1 |
| Mellanby, J | 1 |
| Strawbridge, P | 1 |
| Collingridge, GI | 1 |
| George, G | 1 |
| Rands, G | 1 |
| Stroud, C | 1 |
| Thompson, P | 1 |
| Portavella, M | 1 |
| Depaulis, A | 2 |
| Vergnes, M | 2 |
| Yoshimoto, M | 1 |
| Kamioka, T | 1 |
| Miyadera, T | 1 |
| Kobayashi, S | 1 |
| Takagi, H | 2 |
| Ager, IR | 1 |
| Danswan, GW | 1 |
| Harrison, DR | 1 |
| Kay, DP | 1 |
| Kennewell, PD | 1 |
| Taylor, JB | 1 |
| Archer, GA | 1 |
| Kalish, RI | 1 |
| Ning, RY | 2 |
| Sluboski, BC | 1 |
| Stempel, A | 1 |
| Steppe, TV | 1 |
| Sternbach, LH | 2 |
| Tahara, T | 2 |
| Araki, K | 2 |
| Shiroki, M | 2 |
| Matsuo, H | 1 |
| Munakata, T | 1 |
| Shoji, T | 1 |
| Sakurada, S | 1 |
| Kisara, K | 1 |
| Sunjić, V | 1 |
| Kuftinec, J | 1 |
| Kajfez, F | 1 |
| Piret, B | 1 |
| Becker, A | 1 |
| Ruethrich, HL | 1 |
| Schneider, R | 1 |
| Grecksch, G | 1 |
| Matthies, H | 1 |
| Bhattacharya, SK | 1 |
| Mitra, SK | 1 |
| File, SE | 2 |
| Wilks, LJ | 2 |
| Krsiak, M | 1 |
| Treit, D | 1 |
| Traversa, U | 1 |
| de Angelis, L | 1 |
| Della Loggia, R | 1 |
| Bertolissi, M | 1 |
| Nardini, G | 1 |
| Vertua, R | 1 |
| Hansen, S | 1 |
| Ferreira, A | 1 |
| Selart, ME | 1 |
| Bernard, PS | 1 |
| Bennett, DA | 1 |
| Pastor, G | 1 |
| Yokoyama, N | 1 |
| Liebman, JM | 1 |
| Danneberg, P | 2 |
| Böke-Kuhn, K | 2 |
| Bechtel, WD | 1 |
| Lehr, E | 2 |
| Baldwin, HA | 1 |
| Johnston, AL | 1 |
| Nakao, K | 1 |
| Higashio, T | 1 |
| Inukai, T | 1 |
| Carlini, EA | 1 |
| Leite, JR | 1 |
| Tannhauser, M | 1 |
| Berardi, AC | 1 |
| Heilman, RD | 1 |
| Bauer, EW | 1 |
| Da Vanzo, JP | 1 |
| Asami, Y | 1 |
| Otsuka, M | 1 |
| Hirohashi, T | 1 |
| Inaba, S | 1 |
| Yamamoto, H | 2 |
| Ferrini, R | 1 |
| Miragoli, G | 1 |
| Taccardi, B | 1 |
| Mayer, O | 1 |
| Barnett, A | 1 |
| Goldstein, J | 1 |
| Fiedler, EP | 1 |
| Taber, RI | 1 |
| Baker, WW | 1 |
| Nakanishi, M | 1 |
| Tsumagari, T | 1 |
| Pool, W | 1 |
| Randall, LO | 1 |
| Goldberg, ME | 1 |
| Sledge, K | 1 |
| Dubinsky, B | 1 |
| Robichaud, RC | 2 |
| van Riezen, H | 1 |
| van der Burg, WJ | 1 |
| Berendsen, H | 1 |
| Jaspar, ML | 1 |
| Saito, C | 1 |
| Sakai, S | 1 |
| Yukawa, Y | 1 |
| Gylys, JA | 1 |
| Sledge, KL | 1 |
| Hillyard, IW | 1 |
| Schut, RN | 1 |
| Ward, FE | 1 |
| Rodriguez, R | 1 |
| Wohlfarth-Ribbentrop, A | 1 |
| Schaumann, W | 1 |
| Christmas, AJ | 1 |
| Maxwell, DR | 1 |
| Bavin, PM | 1 |
| Ganellin, CR | 1 |
| Loynes, JM | 1 |
| Spickett, RG | 1 |
| Haas, H | 1 |
| Jantos, W | 1 |
47 other studies available for pentylenetetrazole and Aggression
| Article | Year |
|---|---|
Single pentylenetetrazole exposure increases aggression in adult zebrafish at different time intervals.
Topics: Aggression; Animals; Behavior, Animal; Disease Models, Animal; Female; GABA Antagonists; Male; Penty | 2019 |
Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.
Topics: Aggression; Anilides; Animals; Anxiety; Behavior, Animal; Brain; Child Development Disorders, Pervas | 2014 |
CONTRASTING BEHAVIORAL, PHARMACOLOGICAL, NEUROPHYSIOLOGICAL, AND BIOCHEMICAL PROFILES OF C57 B1/6 AND SC-I STRAINS OF MICE.
Topics: Adrenal Glands; Aggression; Animals; Avoidance Learning; Behavior, Animal; Chlorpromazine; Mice; Neu | 1963 |
Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative.
Topics: Aggression; Anesthesia; Animals; Anticonvulsants; Azepines; Behavior, Animal; Conflict, Psychologica | 1984 |
Metabolic and behavioral consequences of lidocaine-kindled seizures.
Topics: Aggression; Amygdala; Animals; Electroshock; Glucose; Humans; Lidocaine; Limbic System; Male; Pentyl | 1984 |
Central depressive action of two N-aminomethyl derivatives of diethylpyridinedione.
Topics: Aggression; Amphetamine; Animals; Anticonvulsants; Humans; Male; Mice; Motor Activity; Pentylenetetr | 1983 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; | 1982 |
Caffeine antagonizes several central effects of diazepam.
Topics: Aggression; Animals; Caffeine; Cats; Central Nervous System; Conflict, Psychological; Diazepam; Huma | 1981 |
Behavioural correlates of an experimental hippocampal epileptiform syndrome in rats.
Topics: Aggression; Animals; Behavior, Animal; Evoked Potentials; Exploratory Behavior; Hippocampus; Humans; | 1981 |
22-28 kHz ultrasonic vocalizations associated with defensive reactions in male rats do not result from fear or aversion.
Topics: Acetates; Acetic Acid; Aggression; Animals; Avoidance Learning; Electroshock; Fear; Lithium; Male; P | 1993 |
Quantitative structure-activity relationships in minor tranquilizers. Benzodiazepinooxazole derivatives.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anticonvulsants; Bemegride; Benzodiazepines; Drug Synergis | 1977 |
Central nervous system activity of a novel class of annelated 1,4-benzodiazepines, aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-ones.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Chlorprothixene; Drug | 1977 |
Quinazolines and 1,4-benzodiazepines. 82.1 5-Pyrimidyl-and 5-pyrazinylbenzodiazepines.
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Cats; Electroshock; Humans; | 1977 |
Syntheses and structure-activity relationships of 6-aryl-4H-s-triazolo[3,4-c]thieno[2,3-e] [1,4]diazepines.
Topics: Aggression; Animals; Azepines; Female; Humans; Male; Mice; Pentylenetetrazole; Psychotropic Drugs; S | 1978 |
[Effect of beta-phenylethylamine derivatives on the central nervous system. II. Pharmacological effect of the intracerebral administration of metaraminol on the central nervous system].
Topics: Aggression; Anesthesia, Intravenous; Animals; Anticonvulsants; Avoidance Learning; Blepharoptosis; C | 1975 |
Chiral 1,4-benzodiazepine. VII. Cyclization rates of 2-(n-alpha-ammoniumacyl)-amino-5-chloro-benzophenones in the chiral 1,4-benzodiazepin-2-ones.
Topics: Aggression; Amino Acids; Animals; Behavior, Animal; Benzodiazepinones; Benzophenones; Cyclization; E | 1975 |
Opposite effects of pentylenetetrazol on self-defensive and submissive postures in the rat.
Topics: Aggression; Animals; Behavior, Animal; Exploratory Behavior; Grooming; Male; Pentylenetetrazole; Pos | 1992 |
Pharmacological effects on two inbred substrains of AB mice.
Topics: Aggression; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Haloperidol; Hexo | 1991 |
Anxiolytic activity of Panax ginseng roots: an experimental study.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain Chemistry; Conflict, Psychological | 1991 |
Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal.
Topics: Aggression; Animals; Anticonvulsants; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Phen | 1990 |
Effects of muscimol, cetyl-GABA, pentetrazol and picrotoxin on timidity during intraspecies conflict in mice.
Topics: Aggression; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pentylenetetra | 1989 |
Animal models for the study of anti-anxiety agents: a review.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Cats; Condi | 1985 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; El | 1985 |
Behavioural similarities between mother rats and benzodiazepine-treated non-maternal animals.
Topics: Aggression; Animals; Benzodiazepines; Caffeine; Carbolines; Fear; Feeding Behavior; Female; Humans; | 1985 |
CGS 9896: agonist-antagonist benzodiazepine receptor activity revealed by anxiolytic, anticonvulsant and muscle relaxation assessment in rodents.
Topics: Acoustic Stimulation; Aggression; Agonistic Behavior; Animals; Conditioning, Operant; Diazepam; Dose | 1985 |
Pharmacological action of some known and possible metabolites of brotizolam.
Topics: Aggression; Animals; Azepines; Biotransformation; Conflict, Psychological; Electroshock; Hypnotics a | 1986 |
Behavioral effects of acute and chronic administration of caffeine in the rat.
Topics: Aggression; Animals; Behavior, Animal; Caffeine; Drug Administration Schedule; Exploratory Behavior; | 1988 |
Therapeutic safety studies of brotizolam in animals.
Topics: Aggression; Animals; Azepines; Diazepam; Hypnotics and Sedatives; Mice; Pentylenetetrazole; Psychomo | 1986 |
Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
Topics: Aggression; Animals; Bicuculline; Carbamazepine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Ha | 1985 |
Letter: Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents.
Topics: Aggression; Animals; Anticonvulsants; Barbiturates; Cannabis; Humans; Male; Mice; Pentylenetetrazole | 1973 |
Pharmacologic studies with triflubazam (ORF 8063): a new psychotherapeutic agent.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Appetite Depressants; Behavi | 1974 |
The synthesis and pharmacology of a novel benzodiazepine derivative, 1-methyl-5-(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one(ID-540).
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Bemegride; Benzodiazepinones; Cats; Chlo | 1974 |
Neuro-pharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class.
Topics: Aggression; Amphetamine; Animals; Anti-Anxiety Agents; Avoidance Learning; Carbamates; Chlordiazepox | 1974 |
Proceedings: The effect of sodium gamma-hydroxybutyrate on the CNS of rats and mice.
Topics: Aggression; Animals; Anticonvulsants; Depression, Chemical; Dose-Response Relationship, Drug; Explor | 1974 |
The pharmacology of fletazepam a centrally-acting muscle relaxant.
Topics: Aggression; Animals; Anticonvulsants; Avoidance Learning; Benzazepines; Benzodiazepines; Cats; Diaze | 1974 |
Excitatory responses following intracaudate injection of N-methyl-dl-aspartic acid.
Topics: Aggression; Animals; Arousal; Aspartic Acid; Carbachol; Cats; Caudate Nucleus; Humans; Male; Methyla | 1972 |
Studies on psychotropic drugs. 18. Synthesis and structure-activity relationships of 5-phenyl-1,3-dihydro-2H-thieno(2,3-e) (1,4) diazepin-2-ones.
Topics: Aggression; Animals; Azepines; Behavior, Animal; Central Nervous System; Depression, Chemical; Elect | 1973 |
Quinazolines and 1,4-benzodiazepines. 58. The azido group, a novel pharmacophoric substitutent. 7-Azido-5-phenyl-1,4-benzodiazepines.
Topics: Aggression; Animals; Anticonvulsants; Azides; Behavior, Animal; Benzazepines; Cats; Electroshock; Hu | 1973 |
The influence of SKF-525A on the acute pharmacological properties of chlordiazepoxide.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Brain; Chlordiazepoxide; Conflict, Psycho | 1973 |
OI 77, a new tricyclic antidepressant.
Topics: Aggression; Amphetamine; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Cats; Drug Sy | 1973 |
Pharmacological studies on 2-methyl-3(2'-methyl-4'-chlorophenyl)-5-chloro-4[H)-quinazolinone (SL-164).
Topics: Aggression; Analgesics; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Blood Pressu | 1969 |
The pharmacology of prazepam. A new benzodiazepine derivative.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Cats; Chlordiazepoxide; Dia | 1970 |
Bicyclic Mannich bases. 1. Psychotropic activity of 2-(4-aryl-1-piperazinyl)bicyclo(3.3.1)nonan-9-ones and derivatives.
Topics: Aggression; Animals; Behavior, Animal; Bridged-Ring Compounds; Cats; Central Nervous System; Cyclopa | 1972 |
[Animal experimental comparison of tranquilizing effect of doxepine with known psychopharmaceuticals].
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Conditioni | 1969 |
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.
Topics: Aggression; Animals; Chlordiazepoxide; Diazepam; Electroshock; Exploratory Behavior; Humans; Locomot | 1970 |
Compounds affecting the central nervous system. V. Substituted 3-dialkylaminoalkylindenes.
Topics: Aggression; Alkylation; Analgesia; Animals; Central Nervous System; Chemical Phenomena; Chemistry; E | 1969 |
[Modification of central mechanisms of action by anticholinergics].
Topics: Aggression; Amphetamine; Animals; Apomorphine; Atropine; Biperiden; Bridged-Ring Compounds; Central | 1969 |