pentylenetetrazole has been researched along with Acute Disease in 26 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| "All the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole." | 7.81 | Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats. ( Ballesteros-Zebadúa, P; Franco-Pérez, J; Manjarrez-Marmolejo, J, 2015) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| "All the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole." | 3.81 | Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats. ( Ballesteros-Zebadúa, P; Franco-Pérez, J; Manjarrez-Marmolejo, J, 2015) |
| " In acute study, seizures were induced by either pentylenetetrazole (PTZ) injection or maximal electroshock seizures, while in the chronic study, kindling was induced by injecting PTZ (30 mg/kg, s." | 3.76 | Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats. ( Arora, T; Banerjee, BD; Joshi, V; Mahajan, P; Mediratta, PK; Mehta, AK; Mehta, KD; Rathor, N; Sharma, AK; Sharma, KK, 2010) |
| "The present study was to examine the effect on the blood-brain barrier function of a rapid blood pressure elevation and the duration of this pressure during bicuculline and pentylenetetrazol-induced seizures." | 3.68 | The effect of acute hypertension on blood-brain barrier permeability to albumin during experimentally induced epileptic seizures. ( Kaya, M; Oztaş, B, 1991) |
| "Ellagic acid (EA) is a natural dietary polyphenol that has many beneficial properties, including anti-inflammatory, antioxidant, antiviral, antibacterial, and neuroprotective effects." | 1.62 | Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice. ( Pieróg, M; Poleszak, E; Socała, K; Wlaź, P; Wyska, E, 2021) |
| "The different effects of quercetin on seizure threshold may occur through several mechanisms." | 1.43 | Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models. ( Abbasi, E; Hajiali, F; Mohseni, F; Nassiri-Asl, M; Taghiloo, M; Yousefi, F, 2016) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "In two chronic mouse seizure models this clear tasteless oil was found to be reproducibly anticonvulsant." | 1.38 | Triheptanoin in acute mouse seizure models. ( Borges, K; Sweetman, L; Thomas, NK; Willis, S, 2012) |
| "The only seizure test where short-term rapamycin treatment protected mice was against tonic hindlimb extension in the MES threshold test, though this protection waned with longer rapamycin treatment." | 1.38 | The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. ( Dolce, A; Hardwick, JM; Hartman, AL; Santos, P, 2012) |
| "Epileptiform convulsions occurred in presentation of "difficult" experimental tasks." | 1.26 | [Characteristics of the function of the higher portions of the central nervous system of rats subjected to acute hypoxia in the antenatal period]. ( Kruglikov, RI; Maĭzelis, MIa; Zabludovskiĭ, AL, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (15.38) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Mishra, P | 1 |
| Mittal, AK | 1 |
| Rajput, SK | 1 |
| Sinha, JK | 1 |
| Pieróg, M | 1 |
| Socała, K | 1 |
| Wyska, E | 1 |
| Poleszak, E | 1 |
| Wlaź, P | 1 |
| Paiva, DS | 1 |
| Romariz, SAA | 1 |
| Valente, MF | 1 |
| Moraes, LB | 1 |
| Covolan, L | 1 |
| Calcagnotto, ME | 1 |
| Monteiro Longo, B | 1 |
| Islas-Espinoza, AM | 1 |
| Campos-Rodriguez, C | 1 |
| San Juan, ER | 1 |
| Godoy, LD | 1 |
| Liberato, JL | 1 |
| da Silva Junior, PI | 1 |
| dos Santos, WF | 1 |
| Nassiri-Asl, M | 1 |
| Hajiali, F | 1 |
| Taghiloo, M | 1 |
| Abbasi, E | 1 |
| Mohseni, F | 1 |
| Yousefi, F | 1 |
| Li, J | 1 |
| Jiang, G | 1 |
| Chen, Y | 1 |
| Chen, L | 1 |
| Li, Z | 1 |
| Wang, Z | 1 |
| Wang, X | 1 |
| Franco-Pérez, J | 1 |
| Ballesteros-Zebadúa, P | 1 |
| Manjarrez-Marmolejo, J | 1 |
| Joshi, V | 1 |
| Arora, T | 1 |
| Mehta, AK | 1 |
| Sharma, AK | 1 |
| Rathor, N | 1 |
| Mehta, KD | 1 |
| Mahajan, P | 1 |
| Mediratta, PK | 1 |
| Banerjee, BD | 1 |
| Sharma, KK | 1 |
| Zhang, B | 1 |
| Wong, M | 1 |
| Thomas, NK | 1 |
| Willis, S | 1 |
| Sweetman, L | 1 |
| Borges, K | 1 |
| Hartman, AL | 1 |
| Santos, P | 1 |
| Dolce, A | 1 |
| Hardwick, JM | 1 |
| Cavazos, JE | 1 |
| Jones, SM | 1 |
| Cross, DJ | 1 |
| De Sarro, G | 1 |
| Ibbadu, GF | 1 |
| Marra, R | 1 |
| Rotiroti, D | 1 |
| Loiacono, A | 1 |
| Donato Di Paola, E | 1 |
| Russo, E | 1 |
| Tchekalarova, J | 1 |
| Georgiev, V | 1 |
| Xu, K | 1 |
| Stringer, JL | 1 |
| Karpova, MH | 1 |
| Abrosimov, IIu | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Agadzhanian, NA | 2 |
| Torshin, VI | 2 |
| Shevchenko, LV | 2 |
| Elfimov, AI | 2 |
| Cornford, EM | 1 |
| Nguyen, EV | 1 |
| Landaw, EM | 1 |
| Bazyan, AS | 1 |
| Zhulin, VV | 1 |
| Karpova, MN | 1 |
| Klishina, NY | 1 |
| Glebov, RN | 1 |
| Zabludovskiĭ, AL | 1 |
| Maĭzelis, MIa | 1 |
| Kruglikov, RI | 1 |
| Oztaş, B | 1 |
| Kaya, M | 1 |
| Testa, G | 1 |
| Gloor, P | 1 |
| Celesia, GG | 1 |
| Booker, HE | 1 |
| Sato, S | 1 |
| Gaetti, R | 1 |
26 other studies available for pentylenetetrazole and Acute Disease
| Article | Year |
|---|---|
Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice models of epilepsy using antiepileptogenic Nux vomica.
Topics: Acute Disease; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Cog | 2021 |
Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice.
Topics: Acute Disease; Animals; Brain; Ellagic Acid; Male; Mice; Motor Activity; Muscle Strength; Pentylenet | 2021 |
Transplantation of inhibitory precursor cells from medial ganglionic eminence produces distinct responses in two different models of acute seizure induction.
Topics: Acute Disease; Animals; Disease Models, Animal; Electroshock; Female; Hippocampus; Interneurons; Mal | 2017 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
Mygalin: a new anticonvulsant polyamine in acute seizure model and neuroethological schedule.
Topics: Acute Disease; Animals; Anticonvulsants; Cognition; Diazepam; Dizocilpine Maleate; Drug Evaluation, | 2013 |
Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models.
Topics: Acute Disease; Administration, Oral; Animals; Anticonvulsants; Chronic Disease; Convulsants; Disease | 2016 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats.
Topics: Acute Disease; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats.
Topics: Acetylcholinesterase; Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease | 2010 |
Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Enzyme Activation; Epi | 2012 |
Triheptanoin in acute mouse seizure models.
Topics: Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Mice; Mice, Inbred C3H; Pentylenete | 2012 |
The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Animals; Anticonvulsants; Blood Glucose; Blotting, Western; Ce | 2012 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lob | 2004 |
Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Dystrophin; Epilepsy; | 2004 |
Effect of acute versus chronic theophylline administration on acute restraint stress-induced increase of pentylenetetrazol seizure threshold in mice.
Topics: Acute Disease; Animals; Anticonvulsants; Chronic Disease; Convulsants; Dose-Response Relationship, D | 2006 |
Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures.
Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dose-Response Relati | 2008 |
[Effect of cerebral ischemia of various severity on acute seizures and chronic epileptogenesis].
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Brain Ischemia; Carotid Artery Diseases; Chroni | 1998 |
[Effect of carotid glomectomy on seizures induced by corasol].
Topics: Acute Disease; Animals; Carotid Body; Convulsants; Hypoxia; Male; Pentylenetetrazole; Rats; Reflex; | 1998 |
Acute upregulation of blood-brain barrier glucose transporter activity in seizures.
Topics: 1-Butanol; Acute Disease; Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Carbon Radioisotopes | 2000 |
Long-term reduction of benzodiazepine receptor density in the rat cerebellum by acute seizures and kindling and its recovery 6 months later by a pentylenetetrazole challenge.
Topics: Acute Disease; Aging; Animals; Cerebellum; Convulsants; Diazepam; Drug Administration Schedule; Epil | 2001 |
[Characteristics of the function of the higher portions of the central nervous system of rats subjected to acute hypoxia in the antenatal period].
Topics: Acute Disease; Altitude; Animals; Atmosphere Exposure Chambers; Central Nervous System; Conditioning | 1976 |
The effect of acute hypertension on blood-brain barrier permeability to albumin during experimentally induced epileptic seizures.
Topics: Acute Disease; Albumins; Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Evans Blue; Fema | 1991 |
[Effects of acute hypoxia on the development of corazol-induced seizures].
Topics: Acute Disease; Animals; Epilepsy; Hypoxia; Injections, Subcutaneous; Male; Pentylenetetrazole; Rats | 1990 |
Intracarotid pentylenetetrazol injections in the cat.
Topics: Acute Disease; Animals; Carotid Arteries; Cats; Chronic Disease; Electroencephalography; Epilepsies, | 1974 |
Brain and serum concentrations of diazepam in experimental epilepsy.
Topics: Acute Disease; Animals; Brain; Cats; Diazepam; Dose-Response Relationship, Drug; Penicillin G; Penty | 1974 |
[Clinical experience with Cardiazol-Paracodin in bronchopathies of aged persons].
Topics: Acute Disease; Aged; Aging; Bronchitis; Chronic Disease; Cough; Drug Combinations; Humans; Laryngiti | 1972 |