pentylenetetrazole has been researched along with Acute Brain Injuries in 24 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Taken together, although the seizure threshold is reduced in naive Spry2/4(+/-) mice, neurodegeneration and GCD is mitigated following KA induced hippocampal lesions, identifying Spry proteins as possible pharmacological targets in brain injuries resulting in neurodegeneration." | 5.43 | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. ( Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L, 2016) |
| "Pentylenetetrazole (PTZ) is preferred for experimental epilepsy induction." | 4.12 | The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats. ( Bayrak, G; Turkyilmaz, IB; Yanardag, R, 2022) |
| " The rats were decapitated at the 24th or 72nd hour of seizures and brain tissues were obtained for histopathological examination and for measuring levels of malondialdehyde (MDA), glutathione (GSH), reactive oxygen radicals and myeloperoxidase (MPO) activity." | 3.85 | Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure. ( Akakın, D; Atal, SS; Kervancıoğlu Demirci, E; Koyuncuoğlu, T; Üren, D; Vızdıklar, C; Yeğen, BÇ; Yıldırım, Ç; Yılmaz, H; Yüksel, M, 2017) |
| "What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inflammatory effects? What is the main finding and its importance? Chronic administration of oestrogen, progesterone, ER modulators/agonists or blockade of testosterone exhibited anti-inflammatory and antioxidant actions on single seizure-induced neuronal injury, while ER agonists additionally improved memory function and up-regulated CREB signalling and hippocampal GABA(A)α1 receptor density, suggesting that ERα or ERβ receptor activation may be beneficial in protecting against seizure-related oxidative brain injury and cognitive dysfunction." | 1.51 | Oestrogen receptor ERα and ERβ agonists ameliorate oxidative brain injury and improve memory dysfunction in rats with an epileptic seizure. ( Akakın, D; Arabacı Tamer, S; Erzik, C; Karagöz, A; Koyuncuoğlu, T; Yeğen, BÇ; Yüksel, M, 2019) |
| "Ginsenoside Rb1 (Rb1) has been reported to have varieties of neuroprotective effects." | 1.48 | Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling. ( Miao, W; Shi, Y; Teng, J; Zhang, L, 2018) |
| "These data suggest that convulsive seizures can be obtained in FPI-treated rats when NSS is used as an inclusion criterion to select rats with severe injury." | 1.48 | Convulsive seizures and EEG spikes after lateral fluid-percussion injury in the rat. ( Kelly, W; MacWilliams, Z; Patterson, D; Poulsen, A; Poulsen, D; Rau, T; Smith, D, 2018) |
| "Taken together, although the seizure threshold is reduced in naive Spry2/4(+/-) mice, neurodegeneration and GCD is mitigated following KA induced hippocampal lesions, identifying Spry proteins as possible pharmacological targets in brain injuries resulting in neurodegeneration." | 1.43 | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. ( Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L, 2016) |
| "Firstly, seizure latency induced by pentylenetetrazole was significantly prolonged 6 weeks after brain injury in group of SR141716A treatment." | 1.43 | CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus. ( Liu, C; Wang, X; Wang, Y; Wei, N; Zhang, C; Zhang, JG; Zhang, K; Zhao, B, 2016) |
| "When the head injuries were inflicted either at the 15th min." | 1.30 | A common morphological response of astrocytes to various injuries: "dark" astrocytes. A light and electron microscopic analysis. ( Gallyas, F; Ribak, CE; Séress, L; Tóth, P; Tóth, Z, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 14 (58.33) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bayrak, G | 1 |
| Turkyilmaz, IB | 1 |
| Yanardag, R | 1 |
| Fang, Q | 1 |
| Zheng, S | 1 |
| Chen, Q | 1 |
| Chen, L | 1 |
| Yang, Y | 1 |
| Wang, Y | 2 |
| Zhang, H | 1 |
| Chen, J | 1 |
| Tran, NB | 1 |
| Lee, SJ | 1 |
| Koyuncuoğlu, T | 2 |
| Arabacı Tamer, S | 1 |
| Erzik, C | 1 |
| Karagöz, A | 1 |
| Akakın, D | 2 |
| Yüksel, M | 2 |
| Yeğen, BÇ | 2 |
| Shi, Y | 1 |
| Miao, W | 1 |
| Teng, J | 1 |
| Zhang, L | 1 |
| Smith, D | 1 |
| Rau, T | 1 |
| Poulsen, A | 1 |
| MacWilliams, Z | 1 |
| Patterson, D | 1 |
| Kelly, W | 1 |
| Poulsen, D | 1 |
| Immonen, R | 2 |
| Kharatishvili, I | 2 |
| Gröhn, O | 2 |
| Pitkänen, A | 4 |
| Silva, LF | 3 |
| Hoffmann, MS | 3 |
| Gerbatin, Rda R | 1 |
| Fiorin, Fda S | 1 |
| Dobrachinski, F | 1 |
| Mota, BC | 1 |
| Wouters, AT | 1 |
| Pavarini, SP | 1 |
| Soares, FA | 1 |
| Fighera, MR | 3 |
| Royes, LF | 3 |
| Huusko, N | 2 |
| Römer, C | 1 |
| Ndode-Ekane, XE | 1 |
| Lukasiuk, K | 1 |
| Pastore, V | 1 |
| Wasowski, C | 1 |
| Higgs, J | 1 |
| Mangialavori, IC | 1 |
| Bruno-Blanch, LE | 1 |
| Marder, M | 1 |
| Thongrong, S | 1 |
| Hausott, B | 1 |
| Marvaldi, L | 1 |
| Agostinho, AS | 1 |
| Zangrandi, L | 1 |
| Burtscher, J | 1 |
| Fogli, B | 1 |
| Schwarzer, C | 1 |
| Klimaschewski, L | 1 |
| Eslami, M | 1 |
| Sayyah, M | 1 |
| Soleimani, M | 1 |
| Alizadeh, L | 1 |
| Hadjighassem, M | 1 |
| Wang, X | 1 |
| Zhang, C | 1 |
| Liu, C | 1 |
| Zhao, B | 1 |
| Wei, N | 1 |
| Zhang, JG | 1 |
| Zhang, K | 1 |
| Vızdıklar, C | 1 |
| Üren, D | 1 |
| Yılmaz, H | 1 |
| Yıldırım, Ç | 1 |
| Atal, SS | 1 |
| Kervancıoğlu Demirci, E | 1 |
| Rambo, LM | 1 |
| Ribeiro, LR | 1 |
| Lima, FD | 1 |
| Furian, AF | 2 |
| Oliveira, MS | 2 |
| Saraiva, AL | 1 |
| Ferreira, AP | 1 |
| Dutra, FD | 1 |
| Ilhan, A | 1 |
| Iraz, M | 1 |
| Kamisli, S | 1 |
| Yigitoglu, R | 1 |
| Tóth, Z | 1 |
| Séress, L | 1 |
| Tóth, P | 1 |
| Ribak, CE | 1 |
| Gallyas, F | 1 |
| Golarai, G | 1 |
| Greenwood, AC | 1 |
| Feeney, DM | 1 |
| Connor, JA | 1 |
| Swinyard, EA | 1 |
| Lloyd-Smith, DL | 1 |
| Nieschulz, O | 1 |
2 reviews available for pentylenetetrazole and Acute Brain Injuries
| Article | Year |
|---|---|
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; El | 1969 |
The electroencephalogram as a diagnostic aid in neurosurgery: a review.
Topics: Adult; Age Factors; Amobarbital; Brain Diseases; Brain Injuries; Brain Neoplasms; Child; Child, Pres | 1969 |
22 other studies available for pentylenetetrazole and Acute Brain Injuries
| Article | Year |
|---|---|
The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Brain; Brain Injuries; Epilepsy; Glutathione; Male; Nit | 2022 |
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway.
Topics: Animals; Brain Injuries; Caspase 3; Dimethyl Sulfoxide; Epilepsy; Hippocampus; Kindling, Neurologic; | 2023 |
Effects of Gryllus bimaculatus and Oxya chinensis sinuosa extracts on brain damage via blood-brain barrier control and apoptosis in mice with pentylenetetrazol-induced epilepsy.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Endothelial Cells; Epil | 2023 |
Oestrogen receptor ERα and ERβ agonists ameliorate oxidative brain injury and improve memory dysfunction in rats with an epileptic seizure.
Topics: Animals; Avoidance Learning; Brain Injuries; Estrogen Receptor alpha; Estrogen Receptor beta; Male; | 2019 |
Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling.
Topics: Animals; Antioxidant Response Elements; Brain Injuries; Down-Regulation; Epilepsy; Ginsenosides; Glu | 2018 |
Convulsive seizures and EEG spikes after lateral fluid-percussion injury in the rat.
Topics: Animals; Brain Injuries; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; E | 2018 |
MRI biomarkers for post-traumatic epileptogenesis.
Topics: Animals; Area Under Curve; Biomarkers; Brain Injuries; Brain Mapping; Convulsants; Diffusion Tensor | 2013 |
Treadmill exercise protects against pentylenetetrazol-induced seizures and oxidative stress after traumatic brain injury.
Topics: Animals; Brain; Brain Chemistry; Brain Injuries; Convulsants; Electrodes, Implanted; Electroencephal | 2013 |
Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy.
Topics: Animals; Brain Injuries; Brain Waves; Calbindin 2; Cell Death; Cholecystokinin; Convulsants; Disease | 2015 |
Parvalbumin immunoreactivity and expression of GABAA receptor subunits in the thalamus after experimental TBI.
Topics: Animals; Brain Injuries; Disease Models, Animal; Electroencephalography; Epilepsy; Functional Latera | 2014 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazep | 2014 |
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Survival; Disease Models, Animal; Excitatory Ami | 2016 |
Lipopolysaccharide preconditioning prevents acceleration of kindling epileptogenesis induced by traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Convulsants; Disease Models, Animal; Dose-Response Re | 2015 |
CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus.
Topics: Animals; Brain Injuries; Hippocampus; Male; Pentylenetetrazole; Piperidines; Pyrazoles; Rats; Rats, | 2016 |
Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure.
Topics: Animals; Antioxidants; Brain; Brain Injuries; Disease Models, Animal; Epilepsy; Ghrelin; Glutathione | 2017 |
The involvement of Na+, K+-ATPase activity and free radical generation in the susceptibility to pentylenetetrazol-induced seizures after experimental traumatic brain injury.
Topics: Animals; Brain Injuries; Enzyme Activation; Free Radicals; Male; Pentylenetetrazole; Rats; Rats, Wis | 2011 |
Creatine reduces oxidative stress markers but does not protect against seizure susceptibility after severe traumatic brain injury.
Topics: Animals; Brain Injuries; Creatine; Dietary Supplements; Disease Models, Animal; Electroencephalograp | 2012 |
Pentylenetetrazol-induced kindling seizure attenuated by Ginkgo biloba extract (EGb 761) in mice.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Convulsants; Ginkgo biloba; Housing, Animal; Kindli | 2006 |
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis.
Topics: Animals; Brain Injuries; Cerebral Cortex; Convulsants; Diffusion Magnetic Resonance Imaging; Disease | 2007 |
A common morphological response of astrocytes to various injuries: "dark" astrocytes. A light and electron microscopic analysis.
Topics: Animals; Astrocytes; Brain; Brain Injuries; Craniocerebral Trauma; Female; Kainic Acid; Male; Micros | 1997 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
[Experimental retrograde amnesias in mice].
Topics: Amnesia; Animals; Behavior, Animal; Brain Injuries; Humans; Mice; Pentylenetetrazole; Seizures | 1967 |