pentylenetetrazole has been researched along with Absence Seizure in 3437 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Flurothyl inhalation-induced seizures were as clinically effective as electrical inductions with lesser effects on memory functions." | 8.90 | The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely? ( Cooper, K; Fink, M, 2014) |
| " The present study was conducted to evaluate the effect of probiotic supplementation on pentylenetetrazole (PTZ)-induced seizures in rats." | 8.31 | Electrophysiological, histopathological, and biochemical evaluation of the protective effect of probiotic supplementation against pentylenetetrazole-induced seizures in rats. ( Akin, AT; Aygun, H; Karabulut, D; Kızılaslan, N; Sumbul, O, 2023) |
| "Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment." | 8.31 | Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 8.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " Activation of GPR39 by TC-G 1008 facilitated the development of epileptogenesis in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy." | 8.31 | Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy. ( Barałkiewicz, D; Doboszewska, U; Mlyniec, K; Nieoczym, D; Pieróg, M; Sajnóg, A; Sawicki, J; Socała, K; Sowa, I; Szewczyk, B; Wlaź, P, 2023) |
| " We aimed to evaluate the effect of quercetin on pentylenetetrazole- (PTZ-) induced seizures in male mice focusing on its possible anti-neuroinflammatory and anti-oxidative stress." | 8.31 | Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress. ( Amini-Khoei, H; Korani, MS; Lorigooini, Z; Rahimi-Madiseh, M; Tahmasebi Dehkordi, H; Tavakoli, Z, 2023) |
| "Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic epilepsy models with comorbid neurobehavioral and neuroinflammatory parameters." | 8.31 | Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers. ( Ahmad, T; Alasmari, AF; Alasmari, F; Alqahtani, F; Alqarni, SA; Anjum, SMM; Ashraf, W; Imran, I; Javaid, S; Rasool, MF, 2023) |
| " Here, we evaluated its neuroprotective effects at different doses (100 and 200 mg/kg) against pentylenetetrazole (PTZ)-induced seizures." | 8.31 | Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress. ( Dolatshahi, M; Hashemi, P; Karimpour, S; Nazarinia, D, 2023) |
| "Cannabidiol (CBD) is the main active ingredient in the cannabis plant used for treating epilepsy and related diseases." | 8.31 | The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis. ( He, M; Jiang, X; Lu, H; Wang, Q; Wei, M; Zhao, Y, 2023) |
| "To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats." | 8.31 | Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023) |
| " In the present work, BCRP's role as a mechanism that might contribute to drug-resistant epilepsy (DRE) in a mouse model of acute seizures was studied with further assessment of the effect of its inhibition by ko143 and metformin (MET) on lamotrigine (LTG) bioavailability and efficacy." | 8.31 | Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine. ( El-Sayed, NS; Fathelbab, MH; Harby, SA; Khalil, NA; Saleh, SR; Thabet, EH, 2023) |
| " Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures." | 8.31 | Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. ( Antonowski, T; Juranek, J; Podlasz, P; Wiśniewski, K; Wojtkiewicz, J, 2023) |
| " Hence, the methanol extract was further explored for its anticonvulsant potential in pentylenetetrazole (PTZ) induced acute seizures in mice." | 8.31 | Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies. ( Arora, S; Kaur, S; Kumar, N; Rajput, A; Sharma, P; Singh Bedi, PM; Singh, B; Singh, H; Singh, S; Singh, T, 2023) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 8.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| " In this regard, the effects of oxaprozin (OXP) (a nonsteroidal anti-inflammatory drug) on the experimental model of seizure and memory impairment caused by seizures in rats were investigated in the present study." | 8.12 | Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| "Serotonin and fluoxetine, but not sumatriptan, alleviated PTZ-induced seizures by prolonging onset times of myoclonic-jerk and generalized tonic-clonic seizures." | 8.12 | Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats. ( Kilinc, E; Kılınc, YB; Torun, IE, 2022) |
| "Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory." | 8.12 | Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage. ( Emik, S; Sahin, H; Senturk, GE; Yucel, O, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 8.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| " Conversely, higher dose of anandamide, AM404, URB597 (100 µg/mouse) as well as capsaicin (a TRPV1 agonist: 1, 10, or 100 µg/mouse) attenuated the protective effect of diazepam against PTZ-induced seizures." | 8.12 | Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice. ( Manna, SSS, 2022) |
| " In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects." | 8.12 | Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022) |
| " This study investigated the effects and mechanisms of compound 48/80-stimulated mast cell activation on pentylenetetrazole-induced epileptic seizures in rats." | 8.12 | Mast cell activation ameliorates pentylenetetrazole-induced seizures in rats: The potential role for serotonin. ( Cetinkaya, A; Kilinc, E; Tore, F; Torun, IE, 2022) |
| "We aimed to reveal the anti-convulsant effects sulfasalazine and its mechanism in pentylenetetrazole (PTZ)-induced seizures in rats." | 8.02 | The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats. ( Akyol, PY; Bora, ES; Erbaş, O; Karaali, R; Yurtsever, G, 2021) |
| "In spite of use of cannabidiol (CBD), a non-psychoactive cannabinoid, in pediatric patients with epilepsy, preclinical studies on its effects in immature animals are very limited." | 8.02 | Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats. ( Hložek, T; Kubová, H; Mareš, P; Páleníček, T; Uttl, L, 2021) |
| " In this study, it was aimed to investigate the effect of pantoprazole on pentylenetetrazole-induced epileptic seizures in rats and neurotoxicity in the SH-SY5Y cell line." | 8.02 | The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line. ( Ergul, M; Gunes, H; Ozdemir, E; Ozturk, A; Sahin, B; Taskiran, AS, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 8.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " The seizures were induced with pentylenetetrazole (PTZ) intraperitoneally at 170 mg/kg, and diazepam (DZP) was used as the control anticonvulsant (2 mg/kg, oral); PA was tested at 10, 50, and 100 mg/kg orally." | 8.02 | Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. ( Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL, 2021) |
| " In the pentylenetetrazole-induced seizure model, 1, 5, or 10 mg/kg vortioxetine demonstrated a significant dose-dependent decrease in mean spike frequency, an increase in the latency to minor and major seizures, and a decrease in total duration of major seizure and convulsion stage." | 8.02 | Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats. ( Aygun, H; Ayyildiz, M, 2021) |
| " The study looked at how the thiamine supplement impacted pentylenetetrazole (PTZ)-induced seizures in rats and pentylenetetrazole-induced neurotoxicity in the SH-SY5Y cell line." | 8.02 | The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. ( Ergul, M; Taskiran, AS, 2021) |
| " citratus essential oil (EO) and hydroalcoholic extract (E1) from its leaves, as well as of its related compounds citral (CIT) and geraniol (GER) against the effects of pentylenetetrazole (PTZ) induced seizures in zebrafish (Danio rerio)." | 8.02 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish. ( Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP, 2021) |
| " We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats." | 8.02 | Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats. ( Ankarali, H; Ankarali, S; Ayhan, D; Cetinkaya, A; Kilinc, E; Torun, IE, 2021) |
| "The aim of the present study was to investigate the effect of rutin administration (100 mg/kg/day) to pentylenetetrazol (PTZ)-treated Balb-c mice (60 mg/kg/day), with respect to anxiety-like behavior using both open-field and elevated plus-maze (EPM) tests, and acetylcholinesterase (AChE) activity in salt-soluble (SS) fraction and detergent-soluble (DS) fraction of the cerebral cortex, hippocampus, striatum, midbrain, and diencephalon." | 7.96 | Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice. ( Anesti, M; Atsopardi, K; Lamari, FN; Margarity, M; Panagopoulos, NT; Stavropoulou, N, 2020) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| " The main goal of the current study is to investigate the possible anticonvulsant effect of selenium nanoparticles (SeNPs) against pentylenetetrazole (PTZ)-mediated epileptic seizures in mice hippocampus." | 7.96 | Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice. ( Abdel Moneim, AE; Al-Ghamdy, AO; Alkandiri, A; Fu, Z; Guo, L; Habotta, OA; Ji, P; Kassab, RB; Yuan, X, 2020) |
| " This study aimed to investigate the effect of sCT on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole (PTZ)-induced epilepsy model in rats." | 7.96 | The effects of salmon calcitonin on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole-induced epilepsy model in rats. ( Ergul, M; Gumus, E; Ozdemir, E; Taskıran, AS, 2020) |
| "To investigate the neuroprotective effect of ferulic acid (FA) in a pentylenetetrazol (PTZ)-induced seizures model in rat, the motor response, spatial learning ability and memory capability of the rats were assessed." | 7.91 | Ferulic acid ameliorates pentylenetetrazol-induced seizures by reducing neuron cell death. ( Hu, Q; Liu, D; Wang, S; Zhang, SH; Zhou, S; Zhu, J, 2019) |
| "Larval movement times and total distances traveled by zebrafish larvae experiencing pentylenetetrazole (PTZ)-induced seizures were decreased by valproate treatment." | 7.91 | Rongchang and Xifeng capsules suppress pentylenetetrazole-induced seizures and change rest/wake behavior in zebrafish larvae. ( Chen, D; Dai, L; Fang, Y; Feng, D; Feng, X; He, X; Kuang, X; Wang, C; Xu, J; Zhang, S; Zhu, S, 2019) |
| " The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model." | 7.91 | Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy. ( Ahmadian, SR; Ghasemi-Kasman, M; Pouramir, M; Sadeghi, F, 2019) |
| "The use of losartan with sodium valproate in epilepsy may prevent the cognitive and cardiac sequelae of seizures." | 7.91 | Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats. ( Arava, S; Gupta, YK; Joshi, D; Katyal, J, 2019) |
| "The aim of this study is to investigate the therapeutic effects of vitamin U (Vit U) on lung tissue of pentyleneterazole (PTZ)-induced seizures in rats." | 7.88 | The effect of vitamin U on the lung tissue of pentyleneterazole-induced seizures in rats. ( Alev, B; Bayrak, G; Emekli-Alturfan, E; Ipekci, H; Oktay, S; Pisiriciler, R; Tunali-Akbay, T; Turkyilmaz, IB; Ustundag, UV; Yanardag, R; Yarat, A, 2018) |
| "Pentylenetetrazole (PTZ)-induced seizures in Zebrafish models are now widely accepted for investigating human disease epilepsy." | 7.88 | Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish. ( Cui, Y; Han, L; He, Q; Jin, M; Liu, K; Zhang, S, 2018) |
| " The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy." | 7.88 | Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy. ( Chang, LY; Wei, LL; Yu, H; Yu, X; Zhou, T, 2018) |
| " We investigated probable involvement of PPARα in the anticonvulsant effect of DHA in pentylenetetrazole (PTZ) model of clonic seizures." | 7.88 | A role for peroxisome proliferator-activated receptor α in anticonvulsant activity of docosahexaenoic acid against seizures induced by pentylenetetrazole. ( Babaei, J; Gavzan, H; Hashemi, F; Sayyah, M, 2018) |
| " Accordingly, the aim of this study is to determine if coenzyme Q10 (CoQ10) and alpha-tocopherol (α-Toc) have a neuroprotective effect in rats against the observed oxidative stress and inflammation during seizures induced by pentylenetetrazole (PTZ) in rats, and to study their interactions with the conventional antiseizure drug phenytoin (PHT), either alone or in combination." | 7.88 | Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways. ( Al-Khalek, HAA; Khalifa, AE; Masoud, SI; Nagib, MM; Rahmo, RM; Sabri, NA; Tadros, MG, 2018) |
| "Curcumin, derived from turmeric, has been demonstrated to be effective in controlling seizures, although the exact mechanism is yet unknown." | 7.88 | The role of serotonin and its receptors on the anticonvulsant effect of curcumin in pentylenetetrazol-induced seizures. ( Amin, B; Arbabi Jahan, A; Ghanbarabadi, M; Mohammad-Zadeh, M; Rad, A, 2018) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " Ferulic acid is a phenolic phytochemical with antioxidant and neuroprotective properties that prompted us to evaluate its therapeutic potential in epilepsy which is usually associated with oxidative stress and cognitive decline." | 7.85 | Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy. ( Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P, 2017) |
| "In this study, the effects of levosimendan on seizure susceptibility was studied by PTZ-induced seizures model in mice." | 7.85 | Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for K ( Aleyasin, AR; Amini-Khoei, H; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Mojahedi, P; Tabaeizadeh, M; Vafaei, A; Yousefi, F, 2017) |
| " Here, we found that gastrodin ameliorated pentylenetetrazole (PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice." | 7.85 | Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice. ( Chen, L; Liu, X; Qu, M; Wang, H, 2017) |
| " We investigated the effects of oleuropein on pentylenetetrazole (PTZ)-induced seizures in male NMRI mice, with diazepam as the standard drug." | 7.85 | Effects of oleuropein on pentylenetetrazol-induced seizures in mice: involvement of opioidergic and nitrergic systems. ( Dehpour, AR; Delfan, B; Motamed-Gorji, N; Rahimi, N, 2017) |
| " Based on previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish." | 7.85 | Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish. ( Bernabeu, R; Bruno-Blanch, L; Otero, S; Pisera-Fuster, A; Talevi, A, 2017) |
| " Seizures were induced with one of Pentelyntetrazole (PTZ), 4-Aminopyridine (AP) and Strychnine (STR)." | 7.85 | Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats. ( Desalu, OO; Kolo, PM; Olarinoye, JK; Olatunji, LA; Sanya, EO; Soladoye, AO, 2017) |
| " The present study was designed to investigate synergistic anticonvulsant effects of pregabalin with amlodipine on acute seizure model of epilepsy in mice." | 7.85 | Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice. ( Khan, RA; Qureshi, IH; Riaz, A; Siddiqui, AA, 2017) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 7.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| "Our findings indicate that the administration of nicotine may attenuate microglial activity and increase eclampsia-like seizure threshold in rat hippocampus through the α7 nicotinic receptor." | 7.83 | Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor. ( Bao, J; Han, X; Li, X; Liu, H; Liu, Y; Thakur, M; Ye, A, 2016) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 7.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| " In the present study, the effect of tianeptine, an antidepressant, was evaluated against pentylenetetrazole (PTZ)-induced seizures, cognitive impairment and oxidative stress in rats." | 7.83 | Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats. ( Gupta, YK; Prabhakar, P; Reeta, Kh, 2016) |
| " In this study, we aimed to investigate the anticonvulsant effect of acute administration of dextrometrophan on pentylenetetrazole (PTZ)-induced seizures and the probable involvement of the nitric oxide (NO) pathway and NMDA receptors in this effect." | 7.83 | Anticonvulsant effect of dextrometrophan on pentylenetetrazole-induced seizures in mice: Involvement of nitric oxide and N-methyl-d-aspartate receptors. ( Akbarian, R; Chamanara, M; Dehpour, AR; Mohseni, G; Norouzi-Javidan, A; Ostadhadi, S, 2016) |
| " We aim to reveal the anticonvulsant effects of dexketoprofen in pentylenetetrazol (PTZ)-induced seizures in rats." | 7.81 | Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures. ( Aksoy, D; Erbaş, O; Solmaz, V, 2015) |
| "Influence of ozone's treatments in mice submitted to PTZ-induced seizures was studied." | 7.81 | Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors. ( Cedeño, RI; Fernández, OS; Mallok, A; Pérez, AF; Soto, MT; Vaillant, JD; Viart, Mde L; Viebahn-Hänsler, R, 2015) |
| " In this study, we investigate the anti-convulsant and neuroprotective effects of thymoquinone (TQ) and vitamin C against pentylenetetrazole (PTZ)-induced generalized seizures." | 7.81 | Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus. ( Badshah, H; Kim, MO; Lee, HY; Naseer, MI; Ullah, I, 2015) |
| "Montelukast showed anticonvulsant action and led to amelioration of oxidative stress markers in PTZ-induced seizures in rats." | 7.81 | Montelukast inhibits pentylenetetrazol-induced seizures in rats. ( Aksoy, D; Cevik, B; Erbas, O; Solmaz, V, 2015) |
| "All the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole." | 7.81 | Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats. ( Ballesteros-Zebadúa, P; Franco-Pérez, J; Manjarrez-Marmolejo, J, 2015) |
| " In this study, we investigated the expression of JIP3 in temporal lobe epilepsy (TLE) and in a kainic acid (KA)-induced mouse model of epileptic seizures, and determined whether down-regulation of JIP3 can decrease susceptibility to seizures and neuron damage induced by KA." | 7.81 | Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures. ( Chen, X; Chen, Y; Cheng, L; Deng, W; Li, J; Li, Y; Lü, Y; Mi, X; Wang, N; Wang, X; Wang, Z; Xu, X; Zhang, Y, 2015) |
| " Seizures were then induced with pentylenetetrazole (PTZ)." | 7.81 | Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). ( Del Valle-Mojica, LM; Ortíz, JG; Torres-Hernández, BA, 2015) |
| " In the present study, we examined its effect on convulsions, oxidative stress and cognitive impairment in pentylenetetrazole (PTZ) induced seizures in rats." | 7.81 | Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats. ( Gupta, YK; Joshi, R; Reeta, KH; Sharma, SK; Tripathi, M, 2015) |
| "The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats." | 7.81 | Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015) |
| " Since previous works suggested a capacity for HupA to prophylax against seizures, we tested the HupA antiepileptic potential in pentylenetetrazole (PTZ) rat epilepsy model and explored its mechanism of action by spectral EEG analysis and by paired-pulse transcranial magnetic stimulation (ppTMS), a measure of GABA-mediated intracortical inhibition." | 7.81 | Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition. ( Dhamne, SC; Ekstein, D; Gersner, R; Rotenberg, A; Schachter, SC, 2015) |
| " Thus, we suggested that the dual FAAH and TRPV1 blockade with N-arachidonoyl-serotonin (AA-5-HT) would be efficacious in inhibiting pentylenetetrazole (PTZ)-induced seizures in mice." | 7.80 | Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels. ( de Oliveira, AC; Medeiros, DC; Moraes, MF; Moreira, FA; Vilela, LR, 2014) |
| "To explore the effect of edaravone (ED) on apoptosis of hippocampus neurons in seizures rats induced by pentylenetetrazole (PTZ)." | 7.80 | Effect of edaravone on apoptosis of hippocampus neuron in seizures rats kindled by pentylenetetrazole. ( Cheng, XL; Zhang, JJ, 2014) |
| " The occurrence of the pentylenetetrazole (PTZ)-induced seizures in mice was significantly prevented by CLZ, even when exposed a lower dose of CLZ-SLN after administration by the oral route." | 7.80 | Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram. ( Allémann, E; Couraud, PO; Delie, F; González-Trujano, ME; Leyva-Gómez, G; López-Ruiz, E; Miller, F; Quintanar-Guerrero, D; Romero, I; Wekslerg, B, 2014) |
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 7.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 7.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "Besides the clinical applications of penicillamine, some reports show that use of D-penicillamine (D-pen) has been associated with adverse effects such as seizures." | 7.80 | Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways. ( Dehpour, AR; Heidary, MR; Javadi-Paydar, M; Jazaeri, F; Rahimi, N; Sadeghzadeh, M, 2014) |
| ") and some flavonoids in the pentylenetetrazole-induced seizures in mice." | 7.80 | Anticonvulsant and antioxidant effects of Tilia americana var. mexicana and flavonoids constituents in the pentylenetetrazole-induced seizures. ( Aguirre-Hernández, E; Cárdenas-Rodríguez, N; Carmona-Aparicio, L; Coballase-Urrutia, E; González-Trujano, ME; Ruíz-García, M; Sampieri, A, 2014) |
| "We recently discovered that the antidepressant sertraline is an effective inhibitor of hippocampus presynaptic Na+ channel permeability in vitro and of tonic-clonic seizures in animals in vivo." | 7.80 | Sertraline reduces IL-1β and TNF-α mRNA expression and overcomes their rise induced by seizures in the rat hippocampus. ( Aldana, BI; Gómez, CD; Sitges, M, 2014) |
| " This study was envisaged to evaluate the ameliorative effect of Curcumin on depression like behavior and cognitive impairment observed in pentylenetetrazole kindled animals." | 7.79 | Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice. ( Choudhary, KM; Goel, RK; Mishra, A; Poroikov, VV, 2013) |
| "Although caffeine supplementation has a beneficial effect on people with neurological disorders, its implications for oxidative damage related to seizures are not well documented." | 7.79 | Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rats. ( Castro, M; Fighera, MR; Gerbatin, RR; Mota, BC; Rodrigues, FS; Royes, LF; Souza, MA, 2013) |
| "Alterations in the NO pathway play an important role in the development of convulsive seizures via the glutamatergic and GABAergic systems in acute pentylenetetrazole (PTZ) seizure animals." | 7.79 | The threshold of pentylenetetrazole-induced convulsive seizures, but not that of nonconvulsive seizures, is controlled by the nitric oxide levels in murine brains. ( Danjo, S; Itoh, K; Miyai, A; Nakamura, Y; Watanabe, M, 2013) |
| "In the present study the contribution of estradiol in sex-dependent differences of pentylenetetrazole (PTZ)-induced seizures was investigated in rats." | 7.79 | Contribution of estradiol in sex-dependent differences of pentylenetetrazole-induced seizures in rats. ( Hosseini, M; Sadeghnia, HR; Salehabadi, S; Soukhtanloo, M, 2013) |
| ") administration of α-MSH altered PTZ- and pilocarpine-induced seizures." | 7.79 | Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures. ( Guerra, GP; Jesse, AC; Lenz, QF; Marafiga, JR; Mello, CF; Oliveira, SM; Santos, AC; Scimonelli, TN; Temp, FR, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 7.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| " Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice." | 7.79 | Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice. ( Agarwal, NB; Agarwal, NK; Jain, S; Mediratta, PK; Nagpal, D; Sharma, KK, 2013) |
| "We aimed to reveal the anti-convulsant effects of oxytocin (OT) in pentylenetetrazol (PTZ)-induced seizures in rats." | 7.79 | Oxytocin inhibits pentylentetrazol-induced seizures in the rat. ( Bora, S; Erbas, O; Evren, V; Korkmaz, HA; Peker, G; Yılmaz, M, 2013) |
| "To study the effects of noninvasive transcranial focal electrical stimulation (TFS) via tripolar concentric ring electrodes (TCRE) on the electrographic and behavioral activity from pentylenetetrazole (PTZ)-induced seizures in rats." | 7.79 | Effects of transcranial focal electrical stimulation via tripolar concentric ring electrodes on pentylenetetrazole-induced seizures in rats. ( Besio, WG; Gale, K; Makeyev, O; Medvedev, A, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 7.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| " In this study, we tested the hypothesis that a new KYNA analog administered systemically in a sufficient dose results in a decreased population spike activity recorded from the pyramidal layer of area CA1 of the hippocampus, and also provides protection against pentylenetetrazole-induced epileptiform seizures." | 7.78 | A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study : special issue related to kynurenine. ( Demeter, I; Fülöp, F; Gellért, L; Nagy, K; Toldi, J; Vécsei, L, 2012) |
| "Taken together, sub-chronic pioglitazone treatment exerts anti-convulsant effects in intravenous and intraperitoneal pentylenetetrazole-induced seizures of mice probably through induction of constitutive nitric oxide synthase." | 7.78 | Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide. ( Dehpour, AR; Ghorbani, H; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H; Zaeri, M, 2012) |
| " Thus, the present study investigated the influence of anandamide on pentylenetetrazole-induced seizures in mice pretreated with TRPV1 or CB(1) receptor antagonists." | 7.78 | Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. ( Manna, SS; Umathe, SN, 2012) |
| "The present study demonstrates the anticonvulsant effect of acute pioglitazone on PTZ-induced seizures in mice." | 7.78 | Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice. ( Adabi Mohazab, R; Dehpour, AR; Delfan, B; Javadi-Paydar, M, 2012) |
| " mascula (HEOM) tuber was evaluated against seizures, seizure-induced oxidative stress and cognitive deficit in pentylenetetrazole and maximal electroshock-induced seizures in rats." | 7.78 | Anticonvulsant and antioxidative activity of hydroalcoholic extract of tuber of Orchis mascula in pentylenetetrazole and maximal electroshock induced seizures in rats. ( Kumar Gupta, Y; Mehla, J; Pahuja, M, 2012) |
| "Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy." | 7.78 | The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012) |
| "), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine." | 7.78 | The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. ( Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M, 2012) |
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 7.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "To study the different effects of soy extract on pentylenetetrazole (PTZ)-induced seizures in the presence and absence of ovarian hormones in rats, and the gender-dependent differences in the effects of phytoestrogens on behavior." | 7.78 | Estrogen-dependent effect of soy extract on pentylenetetrazole-induced seizures in rats. ( Ebrahimzadeh Bideskan, AR; Enayatfard, L; Hosseini, M; Karami, R; Mohammadpour, T; Sadeghnia, HR, 2012) |
| "To investigate the possible anticonvulsant effect of different extracts of Eugenia caryophyllata (clove) on pentylenetetrazole (PTZ)-induced seizures in mice." | 7.78 | Effects of different extracts of Eugenia caryophyllata on pentylenetetrazole-induced seizures in mice. ( Ghorbani, A; Hosseini, M; Jafarianheris, T; Parvaneh, M; Rakhshandeh, H; Sadeghnia, HR; Seddighi, N, 2012) |
| "Magnesium sulfate (MgSO₄) has been used to prevent seizures in eclampsia." | 7.77 | The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats. ( Futuro Neto, Hde A; Nakamura-Palacios, EM; Oliveira, LD; Oliveira, RW, 2011) |
| " In the current study we investigated whether atorvastatin or simvastatin alters the seizures induced by pentylenetetrazol (PTZ), a classical convulsant." | 7.77 | Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol-induced seizures. ( de Mello, CF; de Oliveira, CV; Ferreira, J; Funck, VR; Furian, AF; Guerra, GP; Mallmann, CA; Oliveira, MS; Pereira, LM; Rambo, LM; Ribeiro, LR; Royes, LF, 2011) |
| " In this study, we tested the effect of pentylenetetrazole (PTZ)-induced seizures on ectonucleotidase and ADA activities in adult zebrafish brain." | 7.77 | PTZ-induced seizures inhibit adenosine deamination in adult zebrafish brain membranes. ( Bogo, MR; Bonan, CD; Capiotti, KM; Piato, AL; Seibt, KJ; Siebel, AM, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 7.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| "In various animals methionine sulfoximine (MSO) induces tonic-clonic seizures resembling the most striking form of human epilepsies." | 7.76 | Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures. ( Cloix, JF; Hévor, T; Martin, B; Tahi, Z, 2010) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 7.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures." | 7.76 | Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice. ( Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 7.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| "Effects of the inhibitor of the expression of Heat shock proteins 70 kDa (Hsp70), quercetin on seizures and movement disorders induced by N-methyl D-aspartate (NMDA) or pentylenetetrazole in adult rats Wistar were investigated using behavioral methods." | 7.76 | [EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures]. ( Ekimova, IV; Feĭzulaev, BA; Guzhova, IV; Nitsinskaia, LE; Pastukhov, IuF, 2010) |
| "Pioglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, is used in inflammatory brain diseases, and it was shown to protect against seizures in genetically epileptic mice." | 7.76 | Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice. ( Abdallah, DM, 2010) |
| " In the present study, using a model of clonic seizures induced with pentylenetetrazole (PTZ) in male Swiss mice, we investigated whether there is any interaction between lithium and either calcium channel blockers (CCBs: nifedipine, verapamil, and diltiazem) or N-methyl-D-aspartate (NMDA) receptor antagonists (ketamine and MK-801) in modulating seizure threshold." | 7.76 | Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Heydarpour, P; Meskar, H; Nazarbeiki, S; Shafaroodi, H; Talab, SS; Ziai, P, 2010) |
| " The effects of the protein synthesis inhibitor cycloheximide (CHX) were examined on the expression and reconsolidation of pentylenetetrazole (PTZ) - induced kindled seizures and for comparative purposes, on the reconsolidation of conditioned fear response (conditioned freezing)." | 7.76 | The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures. ( Bidziński, A; Lehner, M; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D, 2010) |
| " Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats." | 7.76 | Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. ( Gupta, P; Gupta, YK; Mehla, J; Reeta, KH, 2010) |
| "In the present study, the effects of tramadol on pentylenetetrazole (PTZ)-induced seizures and involvement of nitric oxide (NO) were assessed in mice." | 7.76 | Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice. ( Asghari-Roodsari, A; Dehpour, AR; Javadi-Paydar, M; Khodadad, TK; Lesani, A; Norouzi, A; Shirkhodaei, M, 2010) |
| "Although morphine has an anticonvulsant effect in several animal models of seizures, its potential clinical application in epilepsy may be hindered by its adverse effects like opioid tolerance." | 7.76 | Administration of lithium and magnesium chloride inhibited tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Moezi, L; Montaser-Kouhsari, L; Saberi, M; Shafaroodi, H; Ziai, P, 2010) |
| "This study investigated the anticonvulsant effect of 3-alkynyl selenophene (3-ASP) on pilocarpine (PC)-, pentylenetetrazole (PTZ)- and kainic acid (KA)-induced seizures and mortality in 21-day-old rats." | 7.75 | Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA, 2009) |
| " In this study, we investigated the basic mechanism of aminophylline [theophylline-2-ethylenediamine]-induced convulsions and the effects of Brewer's yeast-induced pyrexia in mice." | 7.75 | Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice. ( Araki, H; Kawasaki, H; Ochi, R; Suemaru, K, 2009) |
| " 3,5-DBr-L-Phe was also given as a single bolus prior to pentylenetetrazole (PTZ) injection to induce seizures or prior to the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) to cause disruption of prepulse inhibition (PPI) of startle (sensorimotor gating deficit)." | 7.75 | Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. ( Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2009) |
| "The aim of this study was to determine the correlations among hippocampal damage, spontaneous recurrent seizures (SRS), and mossy fiber sprouting (MFS) using pentylenetetrazole (PTZ) kindling model." | 7.75 | Mossy fiber sprouting, hippocampal damage and spontaneous recurrent seizures in pentylenetetrazole kindling rat model. ( Cai, XF; Chen, JM; Chen, Y; Dang, J; Fang, J; Fu, JJ; Guo, TH; Huang, WJ; Li, FR; Ma, YF; Tian, FF; Wang, XH; Zeng, C, 2009) |
| " This study examined the anticonvulsant activity of its aqueous stem bark extract (100 - 400mg/kg) against maximal electroshock and pentylenetetrazole-induced seizures in rodents." | 7.75 | Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents. ( Ching, FP; Omogbai, EK; Otokiti, IO, 2009) |
| "Oleamide exhibits antiepileptic activity and significantly decreases the degree of pentylenetetrazole-induced seizures." | 7.74 | Effect of oleamide on pentylenetetrazole-induced seizures in rats. ( Abkhazava, D; Avaliani, N; Kiguradze, T; Kuchiashvili, N; Mamulaishvili, I; Mikautadze, E; Mikeladze, E; Nozadze, M; Pkhakadze, V; Solomonia, R, 2008) |
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 7.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| "The present study was aimed to evaluate a liposomal formulation of amiloride on experimental seizure models including the increasing current electroshock seizure threshold test (ICES), pentylenetetrazole (PTZ)-induced seizures and PTZ-induced status epilepticus in mice." | 7.74 | Comparative efficacy of liposome-entrapped amiloride and free amiloride in animal models of seizures and serum potassium in mice. ( Ali, A; Dua, Y; Iqbal Khan, Z; Jalees Ahmad, F; Kolappa Pillai, K; Vohora, D, 2007) |
| "In the present study, we used both histidine decarboxylase-deficient (HDC-KO) mice and wild-type (WT) mice to elucidate the possible role of carnosine in pentylenetetrazol (PTZ)-induced seizures." | 7.74 | Carnosine inhibits pentylenetetrazol-induced seizures by histaminergic mechanisms in histidine decarboxylase knock-out mice. ( Chen, Z; Liu, LY; Ohtsu, H; Wang, S; Wu, DC; Zhu, YY; Zhu-Ge, ZB, 2007) |
| " We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg/kg or 70 mg/kg of pentylenetetrazole (PTZ); the anticonvulsant effect of thalidomide was also compared with that of valproic acid." | 7.74 | Thalidomide inhibits pentylenetetrazole-induced seizures. ( Calderon, A; Palencia, G; Sotelo, J, 2007) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 7.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| " Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels." | 7.74 | Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. ( Rensing, N; Rothman, SM; Thio, LL; Weisenfeld, AE; Wong, M; Xu, L; Yamada, KA; Yang, XF; Zhang, HX, 2008) |
| "To characterize the anticonvulsant effects and types of interactions exerted by mixtures of vigabatrin (VGB) and conventional antiepileptic drugs (valproate (VPA), ethosuximide (ESM), phenobarbital (PB), and clonazepam (CZP)) in pentylenetetrazole (PTZ)-induced seizures in mice, the isobolographic analysis for three fixed-ratio combinations of 1 : 3, 1 : 1, and 3 : 1 was used." | 7.73 | Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Andres, MM; Czuczwar, SJ; Luszczki, JJ; Wojcik-Cwikla, J, 2005) |
| "The effects of tianeptine and fluoxetine on pentylenetetrazole (PTZ)-induced seizures in rats were investigated." | 7.73 | Investigation of the effects of tianeptine and fluoxetine on pentylenetetrazole-induced seizures in rats. ( Ceyhan, M; Kayir, H; Uzbay, IT, 2005) |
| "The aim of this study was to examine the effects of acute fluoxetine treatment on pentylenetetrazol-induced convulsions in order to shape a model of seizures associated with treatment with antidepressants in rats." | 7.73 | The effect of fluoxetine in a model of chemically induced seizures--behavioral and immunocytochemical study. ( Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Taracha, E; Wisłowska, A; Zienowicz, M, 2005) |
| "In the present study, we investigated the effects of micro-injecting 2-chloroadenosine (2-CADO; an adenosine receptor agonist) into the thalamus alone and with theophylline (a nonspecific adenosine receptor antagonist) pretreatment on pentylenetetrazol (PTZ)-induced tonic-clonic seizures in male Wistar albino rats." | 7.73 | Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application. ( Ates, N; Ilbay, G; Sahin, D, 2005) |
| "Isobolographic analysis was used to characterize the interactions between loreclezole (LCZ) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced seizures and in producing acute neurotoxic adverse effects in the chimney test in mice so as to identify optimum combinations." | 7.73 | Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "The aim of this work was to study the effects of prolonged exposure to lead on the threshold of experimental seizures induced by pentylenetetrazole (PTZ)." | 7.73 | Prolonged exposure to lead lowers the threshold of pentylenetetrazole-induced seizures in rats. ( Arrieta, O; García-Arenas, G; Hernández-Pedro, N; Morales-Espinosa, D; Palencia, G; Sotelo, J, 2005) |
| "We investigated the effects of lipopolysachharide (LPS) on functional and structural properties of the blood-brain barrier (BBB) during pentylenetetrazole (PTZ)-induced epileptic seizures in rats." | 7.73 | Effects of lipopolysaccharide on blood-brain barrier permeability during pentylenetetrazole-induced epileptic seizures in rats. ( Ahishali, B; Arican, N; Bilgic, B; Elmas, I; Gurses, C; Kalayci, R; Kaya, M; Kucuk, M; Uzun, H; Uzun, M, 2006) |
| "We investigated whether the severity of blood-brain barrier disruption caused by pentylenetetrazole-induced seizures is modified by long-term nitric oxide synthase inhibition in rats." | 7.73 | Long-term L-NAME treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats. ( Ahishali, B; Arican, N; Elmas, I; Kalayci, R; Kaya, M; Kucuk, M, 2006) |
| " Pentylenetetrazole (PTZ)-induced seizures were used to evaluate the anticonvulsant effect of drugs." | 7.73 | Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine. ( Pillai, KK; Uma Devi, P; Vohora, D, 2006) |
| "The effects of chloroquine on glial fibrillary acidic protein (GFAP), proliferation cell nuclear antigen (PCNA) and Cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole (PTZ) were observed in the present study." | 7.73 | Effects of chloroquine on GFAP, PCNA and cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole. ( Liu, Q; Wang, W; Zhang, S; Zhu, C, 2005) |
| " Anticonvulsant effects were evaluated against seizures induced by both 14 mg/kg of 4-aminopyridine and 110 mg/kg of pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 7.72 | Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Bravo, J; Cuadrado, A, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| "We examined the effect of melatonin on brain levels of amino acids and nitric oxide (NO) after pentylenetetrazole (PTZ)-induced seizures in rats." | 7.72 | Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. ( Acuña-Castroviejo, D; Bikjdaouene, L; Escames, G; Ferrer, JM; Khaldy, H; León, J; Vives, F, 2003) |
| "0 mg kg(-1), significantly and dose-dependently inhibited the seizures induced by pentylenetetrazole." | 7.72 | Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. ( Li, CL; Song, HR; Wang, YL; Wu, CF; Yang, JY; Zhang, HF, 2003) |
| "The purpose of this study was to investigate whether or not clobenpropit, a selective and potent histamine H(3) receptor antagonist, can protect from pentylenetetrazole (35 mg/kg)-kindled seizures in rats." | 7.72 | Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats. ( Chen, J; Chen, Z; Leurs, R; Ren, K; Timmerman, H; Wei, E; Ye, B; Zhang, L; Zhang, W, 2003) |
| "The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice." | 7.72 | Effect of harmane on the convulsive threshold in epilepsy models in mice. ( Aricioglu, F; Berkman, K; Korcegez, E; Yillar, O, 2003) |
| " The present study was undertaken to examine the role of ALLO in the anticonvulsant action of fluoxetine against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.72 | Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice. ( Chopde, CT; Hirani, K; Mittal, N; Ugale, RR, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "The kynurenine pathway converts tryptophan into various compounds, including l-kynurenine, which in turn can be converted to the excitatory amino acid receptor antagonist kynurenic acid, which may therefore serve as a protective agent in such neurological disorders as epileptic seizures." | 7.72 | Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study. ( Farkas, T; Janáky, T; Kis, Z; Marosi, M; Németh, H; Robotka, H; Rózsa, E; Somlai, C; Toldi, J; Vécsei, L, 2004) |
| " Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsions in mice." | 7.71 | Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M, 2002) |
| "A 10 mmol/kg injection of acetone suppressed seizures in 60% of rats (P<0." | 7.71 | Ketogenic diet: does acetone stop seizures? ( Burnham, WM; Likhodii, SS, 2002) |
| " Anticonvulsant effects were evaluated against seizures induced by both 4-aminopyridine and pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 7.71 | Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Cuadrado, A; de las Cuevas, I; Valdizán, EM, 2002) |
| " Dbh -/- mice are hypersensitive to pentylenetetrazole (PTZ)-induced seizures, demonstrating that endogenous NE inhibits PTZ-induced seizures in the wild type." | 7.71 | Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine. ( Miller, NS; Palmiter, RD; Szot, P; Weinshenker, D, 2001) |
| "Molsidomine (25 mg kg(-1)), a donor of nitric oxide, commonly used in the treatment of coronary artery disease, enhanced the protective activity of valproate against the clonic phase of pentylenetetrazole-induced seizures in mice, significantly reducing the ED(50) of valproate from 123." | 7.71 | Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. ( Arent, K; Kleinrok, Z; Tutka, P; Wielosz, M; Łuszczki, J, 2002) |
| " In previous studies, we demonstrated that Stx and lipopolysaccharide (LPS) act in concert to enhance mice sensitivity to pentylenetetrazole (PTZ)-induced seizures via mechanisms involving tumor necrosis factor alpha (TNFalpha), interleukinl beta and nitric oxide." | 7.71 | Enhancement of pentylenetetrazole-induced seizures by Shigella dysenteriae in LPS-resistant C3H/HeJ mice: role of the host response. ( Ashkenazi, S; Nofech-Mozes, Y; Weizman, A; Yuhas, Y, 2002) |
| "The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats." | 7.71 | Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. ( Chaudhary, G; Gupta, YK; Srivastava, AK, 2002) |
| " To compare the CK reaction in GM and WM when ATP metabolism is high, CK reactants and reaction rates were measured in predominantly GM and WM slices in vivo in 2 and 14-day old piglets during pentylenetetrazole (PTZ) seizures using 31P nuclear magnetic resonance (NMR) 1-dimensional chemical shift imaging (CSI)." | 7.70 | In vivo phosphocreatine and ATP in piglet cerebral gray and white matter during seizures. ( Allred, E; Cook, C; Holtzman, D; Jensen, F; Khait, I; Laussen, P; Meyers, R; Mulkern, R; Tsuji, M, 1998) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 7.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| "The anticonvulsant action of NNC 711 [(1-(2-((diphenylmethylene) amino) oxy) ethyl)-1,2,4,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride], an inhibitor of the GABA transporter GAT-1, was studied in a model of pentylenetetrazol-induced motor seizures in rats 7, 12, 18, 25, and 90 days old." | 7.70 | Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. ( Haugvicová, R; Kubová, H; Mares, P, 1998) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 7.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| " In this study, the proconvulsant effects exhibited by a novel series of 6-desfluoroquinolones and some classic quinolones on pentylenetetrazole (PTZ)-induced seizures in mice were evaluated and compared." | 7.70 | Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in mice. ( Cecchetti, V; De Sarro, A; De Sarro, G; Fravolini, V; Naccari, F; Tabarrini, O, 1999) |
| "The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate." | 7.70 | Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1999) |
| " Seizure threshold was tested by intravenous infusion of pentylenetetrazole (PTZ) whereas seizure severity was determined from measuring the hindlimb extension to flexion (E/F) ratio after seizures were evoked by maximal electroshock stimulation (MES)." | 7.70 | A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion. ( Bough, KJ; Eagles, DA; Matthews, PJ, 2000) |
| "The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice." | 7.70 | Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice. ( Pal, SN; Pillai, KK; Vohora, D, 2000) |
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 7.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 7.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| " A nearly fivefold elevation in NO content was found at the peak time of pentylenetetrazole (PTZ)-induced seizures." | 7.70 | Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures. ( Bashkatova, V; Mikoyan, V; Narkevich, V; Rayevsky, K; Vanin, A; Vitskova, G, 2000) |
| "The nitric oxide (NO) synthase inhibitor N omega-nitro-L-arginine (NNA) and the putative brain-selective NO synthase inhibitor 7-nitroindazole (7-NI) were used to determine the role of endogenous NO on seizures induced by kainic acid (KA) in rats and KA, pilocarpine, bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice." | 7.69 | Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. ( Davis, W; Penix, LP; Subramaniam, S, 1994) |
| "Pentylenetetrazole (PTZ) evoked seizures, known to be dependent on stimulation of excitatory amino acids (EAA) receptors, serve as a useful model to study genomic responses to increased brain activity." | 7.69 | AP-1 and CRE DNA binding activities in rat brain following pentylenetetrazole induced seizures. ( Kaczmarek, L; Lukasiuk, K, 1994) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 7.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "The purpose of this investigation was to determine whether paraplegia induced by neoplastic cord compression affects the pharmacodynamics of phenobarbital general anesthesia or of pentylenetetrazol (PTZ)-induced convulsions." | 7.69 | Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. ( Alfon, J; Hoffman, A; Siegal, T, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 7.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| " Therefore, we used this model to study the influence of flunarizine, a calcium antagonist, on kindled seizures as well as related learning impairments." | 7.69 | Flunarizine--its effect on pentylenetetrazol-kindled seizures and on related cognitive disturbances. ( Becker, A; Grecksch, G, 1995) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 7.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| " However, it did not affect seizures elicited by picrotoxin (2." | 7.69 | Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice. ( Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T, 1996) |
| " Insulin was shown to be ineffective to suppress ouabain (5 micrograms/intracerebroventricular) induced seizures." | 7.69 | Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats. ( Akarsu, ES; Ayhan, IH; Cağlar, S; Inan, LE; Kuli, P; Palaoğlu, O; Uysal, H, 1996) |
| "5 g/l in drinking water) on bicuculline- and pentylenetetrazol (PTZ)-induced seizures and c-fos expression were studied in mice." | 7.69 | Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. ( Fredholm, BB; Georgiev, V; Johansson, B; Kuosmanen, T, 1996) |
| "When ddY mice were pretreated with L-carnitine (5, 10 or 20 mmol/kg), clonic as well as tonic seizures induced by pentylenetetrazol (PTZ) were dose-dependently suppressed." | 7.69 | Suppression of pentylenetetrazol-induced seizures by carnitine in mice. ( Igisu, H; Ikeda, M; Iryo, Y; Matsuoka, M; Yu, Z, 1997) |
| " The effects of adenosine, the adenosine analogue, 2-chloroadenosine (2-CADO), the specific adenosine A1 receptor agonist, N6-cyclopentyladenosine (CPA) and A2 receptor agonist 5'-(N-cyclopropyl) carboxamidoadenosine (CPCA), were examined against seizures induced by acute administration of pentylenetetrazole (PTZ), 60 mg kg-1, and PTZ kindled seizures, in rats." | 7.69 | Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| " Disinhibition of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and/or activation of NMDA receptor appears to be factors involved in the initiation and generalization of the pentylenetetrazole (PTZ) induced seizures." | 7.69 | L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice. ( Kaputlu, I; Uzbay, T, 1997) |
| " (Myrtaceae) was studied against lethal seizures induced by intraperitoneal injection of pentylenetetrazole (80 mg/kg), picroptoxin (6 mg/kg), and strychnine (2 mg/kg) in mice." | 7.69 | The leaf essential oil of Psidium guyanensis offers protection against pentylenetetrazole-induced seizures. ( Rao, VS; Santos, FA; Silveira, ER, 1997) |
| " At subeffective doses, beta-eudesmol and phenytoin showed additive effect in preventing electroshock seizures." | 7.69 | Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices. ( Chang, CC; Chiou, LC; Ling, JY, 1997) |
| "The effects of prostaglandin E-analogue misoprostol on the susceptibility to pentilenetetrazol (PTZ)-induced seizures were examined in mice." | 7.69 | Effects of misoprostol on pentylenetetrazol-induced seizures in mice. ( Figueiredo, EG; Medeiros F das, C; Medeiros, MA; Rao, VS, 1997) |
| " The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats." | 7.69 | Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "We have studied the effect of Pentylenetetrazole (PTZ)-induced seizures on the state of phosphorylation of microtubule-associated protein 2 (MAP-2) from rat hippocampus." | 7.68 | Rapid dephosphorylation of microtubule-associated protein 2 in the rat brain hippocampus after pentylenetetrazole-induced seizures. ( Avila, J; Díez-Guerra, FJ, 1993) |
| "The action of ethosuximide (125 or 250 mg/kg, IP) against picrotoxin-induced seizures (3-6 mg/kg, IP) was assessed in rats 12, 18, 25, and 90 days old." | 7.68 | Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. ( Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J, 1993) |
| "Immunohistological and in situ hybridization techniques were used to study the influence of kainic acid-induced seizures and of pentylenetetrazol kindling on neurokinin B immunoreactivity and neurokinin B mRNA in the rat hippocampus." | 7.68 | Limbic seizures cause pronounced changes in the expression of neurokinin B in the hippocampus of the rat. ( Bellmann, R; Krause, JE; Marksteiner, J; Ortler, M; Sperk, G; Wahler, R, 1992) |
| "The influence of sustained epileptic seizures evoked by intraperitoneal injection of kainic acid on the gene expression of the neuropeptides somatostatin and neuropeptide Y and on the damage of neurons containing these peptides was studied in the rat brain." | 7.68 | Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat. ( Bellmann, R; Gruber, B; Mahata, M; Marksteiner, J; Ortler, M; Sperk, G, 1992) |
| "This study determined the effects of bilateral discrete partial lesions of cholinergic neurons of the laterodorsal tegmental nucleus (LDTg) of the pontomesencephalic tegmentum on seizures induced by intravenous pentylenetetrazol (PTZ)." | 7.68 | Effects of selective toxic lesions of cholinergic neurons of the laterodorsal tegmental nucleus on experimental seizures. ( Bardgett, ME; Gray, BC; Miller, JW, 1992) |
| "The anticonvulsant effects of felbamate alone or in combination with diazepam were investigated against maximal electroshock-, pentylenetetrazol-, isoniazid- and bicuculline-induced seizures in mice." | 7.68 | Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1991) |
| "Appearances of pentetrazole-, picrotoxin- and strychnine-induced convulsive seizures in taurine-deficient mice produced by treatment with guanidinoethyl sulfonate (GES), a taurine transport antagonist, were investigated." | 7.68 | [Drug-induced seizures in taurine-deficient mice]. ( Araki, H; Sano, M; Shimada, C; Tanaka, S, 1991) |
| "The anticonvulsant actions of the adenosine receptor agonists, 1-phenylisopropyladenosine, 2-chloroadenosine and cyclohexyl-adenosine, against DMCM (methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate)-induced seizures in mice were studied with an infusion technique." | 7.68 | Selective protection by adenosine receptor agonists against DMCM-induced seizures. ( Petersen, EN, 1991) |
| "This study evaluates the glycine potentiation of anticonvulsant drugs in subcutaneous pentylenetetrazol seizures in rats." | 7.68 | Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats. ( Peterson, SL, 1991) |
| " Its protective efficacy against theophylline-induced seizures was determined in this investigation in view of the limited effectiveness of presently available anticonvulsants against this manifestation of serious theophylline intoxication." | 7.68 | Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| " Effect of quinine on electroshock and pentylenetetrazol (leptazol)-induced seizures was investigated in mice." | 7.68 | Effect of quinine on electroshock and pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Sokomba, E; Wambebe, C, 1990) |
| "The effects of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole were studied in mice." | 7.68 | Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice. ( Kaneto, H; Miwa, T; Nakamura, J; Sasaki, H; Shibasaki, J, 1990) |
| "Fumitremorgin A (FTA), a neurotropic mycotoxin induced dose-dependent abnormal behaviors, including tremor, clonic convulsion, kangaroo posture and tonic extensor convulsion in the mouse." | 7.67 | Abnormal behavioral effects elicited by a neurotropic mycotoxin, fumitremorgin A in mice. ( Kikkawa, K; Suzuki, S; Yamazaki, M, 1984) |
| "The potencies of seven benzodiazepines (BDZs) were established by three tests: inhibition of [3H]flunitrazepam receptor binding, inhibition of [3H]adenosine uptake, and prevention of pentylenetetrazol-induced seizures in mice." | 7.67 | Benzodiazepine inhibition of flunitrazepam receptor binding, adenosine uptake, and pentylenetetrazol-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Wolf, HH, 1984) |
| "Injections of 5,7-dihydroxytryptamine (5,7-DHT) in the rat ventromedial tegmentum, which depleted forebrain serotonin, and of 6-hydroxydopamine in the dorsal noradrenergic bundle, which caused a marked reduction of forebrain noradrenaline, intensified pentylenetetrazol (PTZ)-induced seizures." | 7.67 | Evidence that the dorsal raphe area is involved in the effect of clonidine against pentylenetetrazole-induced seizures in rats. ( Bendotti, C; Lazarova, M; Samanin, R, 1984) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 7.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "The threshold for pentylenetetrazol (PTZ)-induced clonic seizures is below control levels 15 min after administration of apomorphine (APO) but above them 60 min after APO administration." | 7.67 | Effects of ascorbate on a dopaminergic response: apomorphine-induced modification of pentylenetetrazol-induced seizures in mice. ( Goldman, CP; Riffee, WH; Wilcox, RE; Young, RK, 1984) |
| "The purposes of this investigation were to determine the effect of pregnancy on the susceptibility of female rats to experimentally induced seizures and on the relationship between serum phenytoin concentration and antiseizure activity." | 7.67 | Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats. ( Chou, RC; Levy, G, 1984) |
| "The seizure sensitive Mongolian gerbil, a genetic model of epilepsy, has been used to investigate the effects of prior spontaneous seizures on the threshold for pentylenetetrazole (PTZ) and maximum electroshock (MES) induced convulsions." | 7.67 | The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil. ( Lee, RJ; Lomax, P, 1984) |
| "The goal of this study was to test the hypothesis that phentolamine and propranolol premedication would affect tonus differently than clonus in pentylenetetrazol (PTZ)-induced tonic-clonic seizures in dogs." | 7.67 | Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs. ( Cunningham, JG; Stephenson, RB, 1984) |
| "Changes in immunoreactivity of calcitonin gene-related peptide (CGRP) were investigated in the brains of rats subsequently to seizures induced by intraperitoneal injection of kainic acid (10 mg/kg, i." | 7.67 | Pronounced increases in brain levels of calcitonin gene-related peptide after kainic acid induced seizures. ( Humpel, C; Marksteiner, J; Saria, A; Sperk, G, 1989) |
| "An anticonvulsant action of ketamine, a noncompetitive NMDA receptor antagonist (1-40 mg/kg IP), on the metrazol-induced seizures was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.67 | Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. ( Blanková-Vanková, S; Mares, P; Mikolásová, R; Velísek, L, 1989) |
| "The effects of the diterpene sclareol glycol (SG) of the labdane family on convulsive seizures induced by pentylenetetrazole (PTZ), picrotoxin and bicuculline in mice were studied." | 7.67 | Effects of the diterpene sclareol glycol on convulsive seizures. ( Georgieva, J, 1989) |
| "L-lysine, an essential amino acid for man and animals, and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice." | 7.67 | Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures. ( Chang, YF; Chen, JS; Hargest, V, 1988) |
| "In mice, the influence of small (analgesic range) doses of morphine, fentanyl, meperidine and pentazocine on the thresholds for seizures induced by electroshock and pentetrazole was studied." | 7.67 | Effect of morphine and morphine-like analgesics on susceptibility to seizures in mice. ( Czuczwar, SJ; Frey, HH, 1986) |
| "The effects of cinromide on two types of metrazol-induced seizures were studied in 236 male rats aged 7, 12, 18, 25 and 90 days." | 7.67 | Influence of cinromide on metrazol--induced seizures during ontogenesis in rats. ( Bernásková, K; Mares, P; Rokyta, R, 1988) |
| "The effects of acute exposure to acrylonitrile (ACN), 10, 20, or 40 mg/kg by gavage, on the ability of metrazol (MTZ) to induce seizures was studied in adult, male Sprague-Dawley rats." | 7.67 | Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat. ( Adams, PM; Ahmed, AE; Fanini, D; Sadagopa Ramanujam, VM; Trieff, NM, 1985) |
| "Lysine and its metabolic intermediates were studied for their effect on pentylenetetrazol (PTZ)-induced seizures in mice." | 7.67 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "An association has recently been proposed between the incidence of seizures and prolonged consumption of the phenylalanine-containing artificial sweetener, aspartame." | 7.67 | Administration of aspartame potentiates pentylenetetrazole- and fluorothyl-induced seizures in mice. ( Maher, TJ; Pinto, JM, 1988) |
| "The ability of betaine to block homocysteine, pentylenetetrazol, and electroshock induced seizures in mice has previously been observed." | 7.67 | Effects of betaine on seizures in the rat. ( Freed, WJ; Ghoz, EH, 1985) |
| "Acute administration of phenytoin (40 and 75 mg/kg) was unable to counteract seizures induced by pentylenetetrazole and even prolonged them in some cases." | 7.67 | Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse. ( File, SE; Pellow, S; Wilks, L, 1985) |
| "The antagonism of various components of maximal metrazol-seizures and the induction of ataxia have been studied in mice and rats by comparing Denzimol to 10 standard antiepileptic drugs." | 7.67 | Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and mice. ( Ibba, M; Testa, R; Vanasia, A, 1985) |
| "The anticonvulsant effects of clonazepam, nitrazepam and chlordiazepoxide alone, or combined with diphenylhydantoin, were studied on pentylenetetrazol- and bicuculline-induced seizures." | 7.66 | Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, L, 1982) |
| "70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures." | 7.66 | Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures. ( Anisman, H; Hill, DA; Ings, R; Pappas, BA, 1983) |
| "In adult male albino BALB/c mice inosine (INS, 100 and 200 micrograms, intraventricularly) prolonged the latency of pentylenetetrazol (PTZ) seizures while nicotinamide (NAM) exerted an opposite effect." | 7.66 | Dissimilar effects of nicotinamide and inosine, putative endogenous ligands of the benzodiazepine receptors, on pentylenetetrazol seizures in four strains of mice. ( Lapin, IP, 1980) |
| "Nicotinamide (NAM, 1000 mg/kg), inosine (INS, 1000 mg/kg), hypoxanthine (HXT, 500 mg/kg), putative endogenous ligands of the benzodiazepine receptor, and nicotinic acid (NA, 500 mg/kg) diminished DL-kynurenine-(DL-K, 50 micrograms ICV) induced seizures in C57BL/6 adult male mice and only prolonged the latency of pentylenetetrazol (PTZ, 500 micrograms iCV) seizures." | 7.66 | Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures. ( Lapin, IP, 1981) |
| "10 mg/kg yohimbine significantly reduced the latency to the first convulsion of rats treated with 90 mg/kg pentylenetetrazol (PTZ) and markedly increased the number of animals showing generalized strong clonic seizures and dying within 1 h." | 7.66 | Potentiation by yohimbine of pentylenetetrazol-induced seizures in rats: role of alpha 2 adrenergic receptors. ( Lazarova, M; Samanin, R, 1983) |
| "The dose response curves of picrotoxin-induced seizures and pentylenetetrazol-induced seizures were shifted to the right by the benzodiazepine (BZ) receptor agonist lorazepam, and to the left by the inverse agonists, DMCM, ZK 90886, FG 7142 and CGS 8216." | 7.66 | Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures. ( Jensen, LH; Petersen, EN, 1983) |
| "The effect of valproic acid and 10 close analogues (7 branched and 3 non-branched) were studied on the content of gamma-aminobutyric acid (GABA) in brain and on seizures induced by pentylenetetrazol (PTZ) in mice." | 7.66 | The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice. ( Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J, 1983) |
| "In several species, larger doses of systemically-administered morphine induce seizures while smaller doses potentiate chemically-induced convulsions." | 7.66 | Effect of morphine pretreatment on pentylenetetrazol-induced seizures in the rat. ( Wallenstein, M, 1983) |
| "The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice." | 7.66 | Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice. ( Bruni, J; Hammond, EJ; Wilder, BJ, 1981) |
| "Based on previous work examining the effects of dextroamphetamine on pentylenetetrazol (PTZ)-induced clonic seizure threshold, the objective of the present study was to determine the effects of two other dopamine agonists, apomorphine (AP) and piribedil, on PTZ seizures." | 7.66 | Effects of apomorphine and piribedil on pentylenetetrazol-induced seizures in mice. ( Goldman, CP; Riffee, WH; Smith, RV; Wilcox, RE, 1981) |
| "5 mg/kg clonidine significantly increased the latency to the first convulsion and reduced tonic seizures and mortality caused by pentylenetetrazol (PTZ), 90 mg/kg, administered subcutaneously to rats." | 7.66 | Serotonin mediation of the protective effect of clonidine against pentylenetetrazol-induced seizures in rats. ( Lazarova, M; Samanin, R, 1983) |
| "Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia." | 7.66 | Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia. ( Amory, DW; Heavner, JE, 1981) |
| " Intracerebroventricular administration of inosine to mice of the C3H/HEN and NIH general purpose strains caused a dose- and time-dependent increase in the latency to clonicotonic seizures produced by intraperitoneal administration of the convulsant pentylenetetrazole." | 7.66 | Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures. ( Marangos, PJ; Moncada, V; Paugh, BA; Paul, SM; Skolnick, P; Syapin, PJ, 1979) |
| "The neutral glycolipids of rabbit central cortex were analyzed during epileptic seizures produced by insulin or pentetrazol injection." | 7.66 | Effect of insulin-induced epileptic seizures on neutral glycolipids of rabbit cerebral cortex. ( Freysz, L; Mandel, P; Mesdjian, D; Mesdjian, JL; Rebel, G, 1978) |
| " Cycloheximide, which antagonizes the puromycin-induced amnesia 3 hours after training, also antagonizes the puromycin effect on susceptibility to seizure." | 7.64 | Puromycin effect on memory may be due to occult seizures. ( Barondes, SH; Cohen, HD, 1967) |
| "Seizures are a combination of electrical and behavioral events that can induce biochemical, molecular, and anatomic changes." | 6.66 | Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits. ( Adem, A; Alachkar, A; Frank, A; Ojha, SK; Sadek, B; Sadeq, A; Stark, H, 2020) |
| "Epilepsy is a complex neurological disease characterized by spontaneous recurrent seizures that affect around 1% of the global population." | 5.91 | Comprehensive characterization of amino acids and water-soluble vitamins in a pentylenetetrazole-induced seizures rat model. ( Jiang, X; Liu, J; Wang, Y, 2023) |
| "Pretreatment with rosiglitazone significantly prevented the progression of kindling in comparison with control group." | 5.91 | Effect of Rosiglitazone, the Peroxisome Proliferator-Activated Receptor (PPAR)-γ Agonist, on Apoptosis, Inflammatory Cytokines and Oxidative Stress in pentylenetetrazole-Induced Seizures in Kindled Mice. ( Amini, A; Ayatollahi, AA; Chen, S; Koohsar, F; Li, J; Wang, F; Zeyghami, MA; Zhang, J, 2023) |
| "Epilepsy is one of the most serious worldwide neurological disorders that lead to the cognitive-psychosocial insults in recurrent seizures." | 5.91 | Ceftriaxone and selenium mitigate seizures and neuronal injury in pentylenetetrazole-kindled rats: Oxidative stress and inflammatory pathway. ( Abdelaziz, EZ; Ali, DA; Kolieb, E; Mohamed, AM, 2023) |
| " A major challenge lies in the lack of knowledge about the bioavailability and pharmacodynamic effects of bioactive compounds in this model organism." | 5.91 | Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation. ( Budzyńska, B; Gertsch, J; Kozioł, E; Lee, SM; Morozova, V; Pellegata, D; Skalicka-Woźniak, K; Skiba, A, 2023) |
| " Berberine (BBR), an isoquinoline alkaloid, has shown promising effect in the kindling model of epileptogenesis, but due to the poor oral bioavailability its clinical application is limited." | 5.91 | Neuroprotective effect of Berberine Nanoparticles Against Seizures in Pentylenetetrazole Induced Kindling Model of Epileptogenesis: Role of Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms. ( Bhatia, A; Bhattacharya, S; Chakrabarti, A; Gautam, V; Kumari, P; Rawat, K; Saha, L; Sandhu, A; Singh, N; Sinha, VR, 2023) |
| "Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population." | 5.91 | Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| "nitidula leaves showed significant anti-seizure effects in the primary screen and were selected for further study." | 5.72 | Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae. ( Aizawa, H; Gwedela, MNV; Lampiao, F; Matsunami, K; Terai, H, 2022) |
| "Dravet syndrome is characterized by multiple seizure types: generalized tonic-clonic, focal, myoclonic, and absence seizures." | 5.72 | Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels. ( Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M, 2022) |
| "Seizures are a disorder caused by structural brain lesions, life-threatening metabolic derangements, or drug toxicity." | 5.72 | Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside. ( Andrade, AR; Barbas, LAL; Ferreira, LO; Hamoy, AO; Hamoy, M; Jóia de Mello, V; Leitão, DS; Lopes, DCF; Martins, MFC; Medeiros, NCL; Muto, NA; Santos, VC, 2022) |
| " Hence, reducing VPA dosage to minimize side effects while maintaining its efficacy is necessary, and transcranial photobiomodulation (tPBM) add-on therapy could facilitate this." | 5.72 | Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats. ( Chang, H; Chang, SF; Tsai, CM, 2022) |
| " However, the low bioavailability of resveratrol and the difficulty of reaching the targeted location in the brain reduce its efficacy considerably." | 5.72 | Resveratrol-Loaded Glutathione-Coated Collagen Nanoparticles Attenuate Acute Seizures by Inhibiting HMGB1 and TLR-4 in the Hippocampus of Mice. ( Aggarwal, NB; Akhter, J; Arora, I; Asad, M; Hoda, U; Rastogi, S; Samim, M; Siddiqui, MA, 2022) |
| "Allopurinol increases the seizure threshold in PTZ-induced seizure and enhances the survival rate in MES-induced seizure." | 5.72 | The possible role of nitric oxide signaling and NMDA receptors in allopurinol effect on maximal electroshock- and pentylenetetrazol-induced seizures in mice. ( Asgari Dafe, E; Dehpour, AR; Faghir-Ghanesefat, H; Farzad Maroufi, S; Modabberi, S; Rahimi, N; Shayan, M, 2022) |
| "Evidence suggests that improving brain inflammation can inhibit the epileptogenesis process and help the emergence of new drugs for the treatment of epilepsy." | 5.72 | Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model. ( Akkaya, R; Filiz, AK; Karabulut, S, 2022) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 5.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "We induced seizure using intravenous administration of PTZ." | 5.72 | The Role of the NMDA Receptor in the Anticonvulsant Effect of Ellagic Acid in Pentylenetetrazole-Induced Seizures in Male Mice. ( Amini-Khoei, H; Boroujeni, SN; Lorigooini, Z; Rahimi-Madiseh, M; Taji, M, 2022) |
| "Epilepsy is characterized by the occurrence of seizures, and the high prevalence of epilepsy-associated comorbidities affects the quality of patients' life." | 5.72 | Pentylenetetrazole-induced seizures cause impairment of memory acquisition and consolidation in zebrafish (Danio rerio). ( Bertoncello, KT; Bonan, CD; Zanandrea, R, 2022) |
| "Seizures were induced by pentylenetetrazol and maximal electroshock." | 5.72 | Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 5.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "Ferulic acid treatment, on the other hand, significantly decreased seizure susceptibility and depression like behavior, possibly because of increased progesterone, restored estradiol, corticosterone, monoamines, and GAD enzyme activity." | 5.72 | Ferulic acid inhibits catamenial epilepsy through modulation of female hormones. ( Dhillon, HK; Goel, RK; Singh, T, 2022) |
| "CBD inhibited PTZ-induced seizures in mice." | 5.72 | Cannabidiol effect in pentylenetetrazole-induced seizures depends on PI3K. ( Bellozi, PMQ; da Silva, MCM; de Assis Lima, IV; de Oliveira, ACP; Moraes, MFD; Moreira, FA; Pinto, HPP; Vilela, LR, 2022) |
| "One month after the seizures, we detected a moderate neuronal loss in several hippocampal regions: CA1, CA3, and hilus, but not in the dentate gyrus." | 5.72 | Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats. ( Brazhe, AR; Korzhevskii, DE; Nosova, OI; Postnikova, TY; Semyanov, AV; Trofimova, AM; Zaitsev, AV; Zakharova, MV, 2022) |
| "The latency, frequency and duration of seizures evaluated using EEG recordings from the frontal and parietal cortices of rats showed significant changes demonstrating the inhibition of paroxystic activity." | 5.62 | Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats. ( Contreras-Murillo, G; González-Trujano, ME; Hidalgo-Flores, FJ; López-Najera, CA; Magdaleno-Madrigal, VM; Navarrete-Castro, A; Sánchez, CG, 2021) |
| "In various organisms, stress is a seizure-related comorbidity." | 5.62 | Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish. ( Canzian, J; Franscescon, F; Müller, TE; Rosa, LV; Rosemberg, DB; Souza, TP; Stefanello, FV, 2021) |
| "Perampanel is a new antiepileptic drug with unique mechanism of action - antagonism of AMPA receptors." | 5.62 | Perampanel exhibits anticonvulsant action against pentylentetrazol-induced seizures in immature rats. ( Kubová, H; Mareš, P, 2021) |
| "Epileptic seizures are characterized by imbalanced inhibition-excitation cycle that triggers biochemical alterations responsible for jeopardized neuronal integrity." | 5.62 | Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures. ( Mishra, P; Rajput, SK; Sinha, JK, 2021) |
| "Pentylenetetrazole (45 mg/kg) was given to induce a seizure in the tenth day except for the control." | 5.62 | The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats. ( Taskiran, AS; Tastemur, Y, 2021) |
| "Seizures were evaluated by video-EEG during one hour and scored according to Racine scale." | 5.62 | Effect of Memantine on Pentylenetetrazol-induced Seizures and EEG Profile in Animal Model of Cortical Malformation. ( Cagliari Zenki, K; Calcagnotto, ME; Klippel Zanona, Q; Lazzarotto, G, 2021) |
| "The intensity of convulsion was scored according to a seven-point scale ranging from stage 0-7." | 5.62 | Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice. ( Abiola, AL; Akhigbemen, AM; Chinazamoku, O; Igbe, I; Ogundepo, GE; Okwuofu, EO; Ozolua, RI, 2021) |
| "Pentylenetetrazole (PTZ) was used to induce convulsions in rats through elevating seizure stages, releasing neuroinflammatory mediators and reducing excitatory amino acid transporter 2 (EAAT 2) and γ-aminobutyric acid (GABA) brain contents." | 5.62 | Single step nanospray drying preparation technique of gabapentin-loaded nanoparticles-mediated brain delivery for effective treatment of PTZ-induced seizures. ( Elhabak, M; Salama, AAA; Salama, AH, 2021) |
| "Acute seizures can severely affect brain function and development." | 5.62 | Alterations in mRNA and Protein Expression of Glutamate Receptor Subunits Following Pentylenetetrazole-induced Acute Seizures in Young Rats. ( Kovalenko, AA; Postnikova, TY; Schwarz, AP; Zaitsev, AV; Zakharova, MV; Zubareva, OE, 2021) |
| "As a result, α-asaronol ameliorated seizures with increase of seizure latency, as well as decrease of seizure-like behavior, c-fos expression, and abnormal neuronal discharge in a concentration dependent manner." | 5.56 | Involvement of peroxisome proliferator-activated receptor γ in anticonvulsant activity of α-asaronol against pentylenetetrazole-induced seizures in zebrafish. ( Bai, Y; Jin, M; Li, X; Liu, K; Sik, A; Sun, Y; Zhang, B; Zhang, S; Zheng, X, 2020) |
| "Here, we studied pentylenetetrazole seizure-induced regulation of genes for plasminogen activator system in the mouse brain." | 5.56 | Urokinase receptor and tissue plasminogen activator as immediate-early genes in pentylenetetrazole-induced seizures in the mouse brain. ( Anokhin, KV; Gruzdeva, AM; Ivashkina, OI; Rubina, KA; Rysenkova, KD; Semina, EV; Shmakova, AA; Tkachuk, VA, 2020) |
| "In India, it is used for the treatment of epilepsy as traditional medicine." | 5.56 | An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy. ( Dinda, AK; Kaleekal, T; Katyal, J; Pattnaik, SS; Sarangi, SC, 2020) |
| "Epileptic seizures are characterized by synchronized discharges of neurons, leading to the activation of inflammatory responses that in turn contributes to seizure progression." | 5.56 | Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. ( Ji, X; Jin, M; Liu, K; Sik, A; Wang, L; Zhang, B; Zhang, S, 2020) |
| "Mean total seizure score decreased by 48." | 5.56 | Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures. ( Abdel-Salam, OME; Sayed, MAEBM; Shaffie, N; Sleem, AA; Youness, ER, 2020) |
| "Convulsive status epilepticus is the most common neurological emergency in children." | 5.56 | Transcranial photobiomodulation attenuates pentylenetetrazole-induced status epilepticus in peripubertal rats. ( Chang, H; Chang, SF; Tsai, CM, 2020) |
| "In contrast, the same ES inhibited EEG seizures when delivered after a combination of DIA‑1." | 5.56 | Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats. ( Godlevsky, LS; Pervak, MP; Shandra, AA; Shandra, OO, 2020) |
| "Previous studies have shown that seizures can cause cognitive disorders." | 5.56 | Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. ( Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M, 2020) |
| "The animals were assessed for seizure score, neuronal damage and inflammatory cytokines levels (IL-1β, IL-6 and TNF-α) in hippocampus." | 5.51 | Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats. ( Banerjee, D; Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N, 2019) |
| "However, the latency time to seizure onset was unaltered." | 5.51 | The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE. ( Hong, Z; Sun, W; Wang, Y; Wu, X; Xu, L; Zhang, L; Zhu, G, 2019) |
| "We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats." | 5.48 | Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018) |
| "Sumatriptan has been among the top choices in the management of migraine headaches." | 5.48 | Biphasic effect of sumatriptan on PTZ-induced seizures in mice: Modulation by 5-HT1B/D receptors and NOS/NO pathway. ( Aghamollaii, V; Ahmadi, M; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Rohani, MM; Tafakhori, A, 2018) |
| "Epilepsy is one of the furthermost common neurodegenerative diseases affecting above 50 million individuals worldwide." | 5.48 | Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy. ( El-Azab, MF; Moustafa, YM; Tawfik, KM, 2018) |
| "The relationships between seizures, neuronal death, and epilepsy remain one of the most disputed questions in translational neuroscience." | 5.48 | Transient Morphological Alterations in the Hippocampus After Pentylenetetrazole-Induced Seizures in Rats. ( Kim, KK; Lavrentyeva, VV; Lukomskaya, NY; Magazanik, LG; Tumanova, NL; Vasilev, DS; Zaitsev, AV; Zhuravin, IA, 2018) |
| "Seizures are sustained neuronal hyperexcitability in brain that result in loss of consciousness and injury." | 5.48 | Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. ( Han, L; He, Q; Ji, X; Jin, M; Liu, K; Sheng, W, 2018) |
| "In six-hertz-seizure test the MeCO (25, 50, 100 and 200mg/kg) and AeCO (50, 100, 200, 400 and 800mg/kg) showed significant protection compared to control group, and MeCO was more potent than AeCO." | 5.46 | Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism. ( Prasad, NBL; Venkataranganna, MV; Viswanatha, GL, 2017) |
| "LCM and LEV were both effective against seizures induced by PTZ." | 5.46 | Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia. ( Alexopoulos, AV; Gonzalez-Martinez, J; Najm, IM; Nemes, AD; O'Dwyer, R; Ying, Z, 2017) |
| "RESV modified brain inflammation during epileptogenesis and found to possess nootropic activity in the kindled mice." | 5.46 | Resveratrol suppressed seizures by attenuating IL-1β, IL1-Ra, IL-6, and TNF-α in the hippocampus and cortex of kindled mice. ( Agarwal, NB; Hoda, U; Parvez, S; Raisuddin, S; Vohora, D, 2017) |
| "Epilepsy is a common brain disorder characterized by the occurrence of recurring, unprovoked seizures." | 5.46 | EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors. ( Cai, M; Cai, S; Chen, L; Duan, S; Gu, H; Lin, R; Ling, C; Lu, J; Pan, X; Wang, Y; Zhu, H, 2017) |
| "Sumatriptan has been used for the acute treatment of migraine attacks." | 5.46 | Sumatriptan, an Antimigraine Drug, Inhibits Pentylenetetrazol-induced Seizures in NMRI Mice. ( Jand, A; Palizvan, MR, 2017) |
| "Understanding how the brain responds to seizures is important for development of new treatment strategies for epilepsy, a neurological condition characterized by recurrent and unprovoked seizures." | 5.46 | Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain. ( Beattie, CE; Berberoglu, MA; Duy, PQ; Hall, CW, 2017) |
| "Taken together, although the seizure threshold is reduced in naive Spry2/4(+/-) mice, neurodegeneration and GCD is mitigated following KA induced hippocampal lesions, identifying Spry proteins as possible pharmacological targets in brain injuries resulting in neurodegeneration." | 5.43 | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. ( Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Neonatal or early-life seizures (ELS) are often associated with life-long neurophysiological, cognitive and behavioral deficits, but the underlying mechanisms contributing to these deficits remain poorly understood." | 5.43 | Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons. ( Atkinson, EW; Coleman, JE; Hoang-Minh, LB; Le, MM; Parker, AK; Sarkisian, MR; Semple-Rowland, S; Smith, TS; Ugartemendia, G, 2016) |
| "Racine convulsion scores, first myoclonic jerk time, spike percentages, and antioxidant status were evaluated in the groups." | 5.43 | Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures. ( Çavuşoğlu, T; Çetin, EÖ; Çınar, BP; Erbaş, O; Solmaz, V; Sur, HY; Uyanıkgil, Y, 2016) |
| "Rosmarinic acid is a naturally occurring substance which displays several biological effects including antioxidant and neuroprotective activity." | 5.43 | Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice. ( Freitas, ML; Furian, AF; Grauncke, AC; Grigoletto, J; Oliveira, CV; Oliveira, MS; Santos, AR; Souto, NS; Souza, TL, 2016) |
| "Behavioral scoring was used to access seizure." | 5.43 | Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. ( Asadi-Shekaari, M; Esmaeili-Mahani, S; Kalantaripour, TP; Pasban-Aliabadi, H; Sheibani, V, 2016) |
| "Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties." | 5.42 | Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish. ( Bogo, MR; Bonan, CD; Capiotti, KM; da Costa Schaefer, I; Da Silva, RS; Frantz, JZ; Kist, LW; Menezes, FP; Siebel, AM, 2015) |
| "Seizures are a known co-occurring symptom of Alzheimer's disease, and they can accelerate cognitive and neuropathological dysfunction." | 5.42 | Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. ( Harrison, FE; Kang, JQ; Kennard, JA; Warner, TA, 2015) |
| "Pentylenetetrazole-induced seizures, in contrast, were not able to change Homer1a mRNA expression." | 5.42 | Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures. ( Blanco, MM; Cavarsan, CF; Matsuo, A; Mello, LE, 2015) |
| "Constipation is a common gastrointestinal disorder characterized by symptoms such as straining, hard stool, and infrequent defecation." | 5.42 | Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "Aripiprazole is a novel atypical antipsychotic." | 5.42 | The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Aripiprazole is an antipsychotic drug which acts through dopamine and serotonin receptors." | 5.42 | The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Levetiracetam (LEV) is a unique, effective, relatively safe antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 5.42 | Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats. ( Abdel-Wahab, BA; Habeeb, SM; Khateeb, MM; Shaikh, IA, 2015) |
| "Erythropoietin (EPO) suppresses epileptic seizures, but the mechanism is unclear." | 5.40 | Erythropoietin pretreatment suppresses seizures and prevents the increase in inflammatory mediators during pentylenetetrazole-induced generalized seizures. ( Akgün-Dar, K; Albeniz, I; Bahçekapılı, N; Kandil, A; Kapucu, A; Üzüm, G; Yağız, O, 2014) |
| "Our study supports the concept of seizure-related modifications in brain cytokine production during epileptogenesis." | 5.40 | The role of interleukin-1β in the pentylenetetrazole-induced kindling of seizures, in the rat hippocampus. ( Kołosowska, K; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D, 2014) |
| "Thalidomide is an old glutamic acid derivative which was initially used as a sedative medication but withdrawn from the market due to the high incidence of teratogenicity." | 5.40 | Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice. ( Ahmadi-Dastgerdi, M; Amanlou, M; Aminizade, M; Bahremand, A; Berijani, S; Dehpour, AR; Dianati, V; Gholizadeh, R; Gooshe, M; Payandemehr, B; Rahimian, R; Sarreshte-Dari, A, 2014) |
| "Metformin was injected intraperitoneally in dose of 200mg/kg along with alternate-day PTZ." | 5.40 | Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. ( Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR, 2014) |
| "Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold." | 5.40 | Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014) |
| "Naringin is a bioflavonoid present in the grapefruit." | 5.40 | Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection. ( Arya, DS; Bhatia, J; Chaudhry, U; Golechha, M; Saluja, D; Sarangal, V, 2014) |
| "Rats with repetitive PTZ-induced seizures demonstrated lower phenytoin-induced anticonvulsant effects, increased number of DiBAC4(3) fluorescence cells and P-gp overexpression in hippocampus and neocortex, as well as augmentation of the induced fEPSP in CA1 field." | 5.39 | P-glycoprotein contributes to cell membrane depolarization of hippocampus and neocortex in a model of repetitive seizures induced by pentylenetetrazole in rats. ( Auzmendi, JA; Bañuelos-Cabrera, I; Calixto González, E; González-Trujano, ME; Lazarowski, A; Orozco-Suárez, S; Rocha, L, 2013) |
| "The incidence of seizures, their expression pattern and their latencies were registered and the severity was expressed by means of a five-point scale." | 5.39 | Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. ( Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B, 2013) |
| "Atorvastatin has shown to possess neuroprotective, antiexcitotoxic, and antiepileptic effects besides its cholesterol-lowering properties." | 5.39 | Anticonvulsive effect of atorvastatin on pentylenetetrazole-induced seizures in mice: the role of nitric oxide pathway. ( Emamzadeh-Fard, S; Moazzami, K; Shabani, M, 2013) |
| "Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex." | 5.39 | Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish. ( Beattie, CE; Hall, CW; Pineda, R, 2013) |
| "In the remaining animals that exhibited seizures, KB-R7943 (3 mg/kg; p." | 5.39 | Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats. ( N'Gouemo, P, 2013) |
| "BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific." | 5.39 | Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013) |
| "KM rats exhibited increased seizure severity relative to Wistar rats, and the death of KM rats was observed in 2." | 5.38 | [The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats]. ( Kim, KKh; Lavrent'eva, VV; Lukomskaia, NIa; Magazanik, LG; Vataev, SI; Zaĭtsev, AV; Zhabko, EP, 2012) |
| "The CD₅₀ values for clonic and tonic seizures after oral administration were 0." | 5.38 | Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. ( Banks, CN; Bruun, DA; Dhir, A; Hammock, BD; Inceoglu, B; Lein, PJ; McCoy, MR; Rogawski, MA; Sanborn, JR; Zolkowska, D, 2012) |
| "Studies have shown that recurrent seizures may increase the concentration of reactive oxygen species, which can lead to oxidative stress and neuronal damage." | 5.38 | Neuroprotective and anticonvulsant effects of organic and conventional purple grape juices on seizures in Wistar rats induced by pentylenetetrazole. ( Coitinho, AS; Dani, C; de Freitas, SC; Fank, B; Henriques, JA; Rodrigues, AD; Salvador, M; Santos, MT; Scheffel, TB; Scola, G; Vanderlinde, R, 2012) |
| "EDA has been shown to reduce seizures caused by systemic injection of proconvulsants in an animal model of generalized tonic-clonic seizures." | 5.38 | Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety. ( Addae, JI; Cruickshank, R; Stone, TW; Walkins, K, 2012) |
| " This protective effect led to a dose-response curve following a U-shaped form." | 5.38 | Neurohypophyseal hormones protect against pentylenetetrazole-induced seizures in zebrafish: role of oxytocin-like and V1a-like receptor. ( Braida, D; Donzelli, A; Martucci, R; Pauletti, A; Ponzoni, L; Sala, M, 2012) |
| "In our previous work the detectors of seizure onset were based on seizure-induced changes in signal power in the frequency range up to 100 Hz, while in this preliminary study we assess the feasibility of recording high frequency oscillations (HFOs) in the range up to 300 Hz noninvasively with scalp TCREs during PTZ-induced seizures." | 5.38 | Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats. ( Besio, WG; Liu, X; Makeyev, O; Medvedev, AV; Taveras, A; Troiano, D; Wang, L; Zhu, Z, 2012) |
| " However, extensive animal studies followed by clinical trials are necessary to develop a product suitable for emergencies of acute seizures in status epilepticus and patients suffering from drug tolerance and hepatic impairment on long-term use in treatment of epilepsy, schizophrenia, and anxiety." | 5.37 | Intranasal clobazam delivery in the treatment of status epilepticus. ( Ambikanandan, M; Ankur, K; Florence, K; Kumar, BA; Kumar, MA; Manisha, L, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 5.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| "Here we report on the development of a seizure detecting algorithm to be used for automatic application of TFS." | 5.37 | Algorithm for automatic detection of pentylenetetrazole-induced seizures in rats. ( Besio, WG; Koka, K; Liu, X; Liu, Y; Medvedev, AV; Sun, YL, 2011) |
| "Overall, the results indicate that seizure may be associated with an increase in energy demand, altered neurotransmitter balance and an increase in neuronal loss and gliosis." | 5.36 | Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain. ( Brennan, L; Carmody, S, 2010) |
| "Minimal clonic seizures in 18-day and older rats were suppressed by high doses of 2-chloroadenosine." | 5.36 | Anticonvulsant action of 2-chloroadenosine against pentetrazol-induced seizures in immature rats is due to activation of A1 adenosine receptors. ( Mareš, P, 2010) |
| "shortening seizure latency and inducing a more profound increase of NO production than PTZ in all brain structures." | 5.36 | Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures. ( Bjelaković, G; Jelenković, A; Jevtović-Stoimenov, T; Pavlović, D; Stevanović, I; Stojanović, I, 2010) |
| "Our data revealed that seizure threshold was increased 6 to 72 hours after nasal obstruction, reaching a peak 48 hours afterward, compared with either control or sham-operated mice (P<0." | 5.35 | Mouth breathing increases the pentylenetetrazole-induced seizure threshold in mice: a role for ATP-sensitive potassium channels. ( Dehpour, AR; Fakhimi, A; Ghasemi, M; Niaki, SE; Shafaroodi, H; Shakiba, B, 2008) |
| "It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood." | 5.35 | Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures. ( Gonzalez-Ramirez, M; Orozco-Suarez, SA; Rocha, L; Salgado-Ceballos, H, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 5.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| " The present study carried out to evaluate the effect of chronic administration of L-arginine (LA) and L-NAME (LN) on pentylenetetrazole (PTZ) induced epilepsy in ovariectomized (OVX) and naïve female rats." | 5.35 | The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo study. ( Alavi, H; Gorji, A; Hosseini, M; Sadeghnia, HR; Salehabadi, S, 2009) |
| "Occurrence of seizures following long-term oral administration of caffeine (0." | 5.35 | Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2008) |
| "In order to generate epileptic seizures, PTZ (50mg/kg) was injected intraperitoneally." | 5.34 | Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. ( Bilgin, HM; Obay, BD; Sermet, A; Tasdemir, E; Tümer, C, 2007) |
| "Progesterone has antiseizure effects, which may be due to the actions of its 5alpha-reduced metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP)." | 5.33 | Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures. ( Frye, CA; Rhodes, ME, 2005) |
| "infusion of PTZ; (2) suppress the seizures (clonic and tonic) and lethality induced by i." | 5.33 | Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice. ( Narenjkar, J; Sayyah, M; Yousefi-Pour, M, 2005) |
| "In PTZ-induced epileptic seizures, the i." | 5.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "Agmatine pre-treatment significantly reduced the seizure grade and increased the onset time." | 5.33 | Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. ( Feng, Y; LeBlanc, MH; Regunathan, S, 2005) |
| " Both acute and chronic administration of quercetin (25 or 50 mg/kg, p." | 5.33 | Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions. ( Joshi, D; Kulkarni, SK; Naidu, PS; Singh, A, 2005) |
| "Recurrent seizures were induced by injecting rat pups with pentylenetetrazole (PTZ) between P10 (10 days of age) and P14." | 5.33 | Menhaden fish oil improves spatial memory in rat pups following recurrent pentylenetetrazole-induced seizures. ( Chaung, HC; Chen, CC; Chung, MY; Huang, LT, 2006) |
| "In the seizure development process, 500 mg/kg carnosine also significantly delayed the onset of PTZ kindled seizures." | 5.33 | Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat. ( Chen, Z; Ding, MP; Jin, CL; Wu, XH; Zhu, YY; Zhu-Ge, ZB, 2006) |
| "No spontaneous seizures occurred and no EEG differences were observed between the genotypes in drug naïve mice." | 5.32 | Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor. ( Berkovic, SF; Drago, J; Finkelstein, DI; Horne, MK; McColl, CD; Wong, JY, 2003) |
| "Latency and incidence of a clonic seizure were recorded." | 5.32 | Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. ( Ahmadiani, A; Mandgary, A; Sayyah, M, 2003) |
| "Seizure activity was observed and seizure patterns and convulsion times were recorded." | 5.32 | Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats. ( Ates, N; Ilbay, G; Sahin, D, 2003) |
| "In the early seizure developmental process, both NR1 and NR2A were markedly increased in the cortex, and NR1 was significantly increased in the hippocampus." | 5.32 | Spatiotemporal changes of the N-methyl-D-aspartate receptor subunit levels in rats with pentylenetetrazole-induced seizures. ( Chen, Z; Luo, JH; Xu, AJ; Xu, SJ; Zhang, LS; Zhu, LJ, 2004) |
| "In PTZ-induced convulsions, the highest dose of agmatine (100 mg/kg) increased the seizure onset time and decreased percent survival." | 5.32 | Effect of agmatine on electrically and chemically induced seizures in mice. ( Aricioglu, F; Berkman, K; Kan, B; Korcegez, E; Yillar, O, 2003) |
| "In PTZ seizure model Kyo and its analogues exerted strong inhibition on seizure intensity compared with control group." | 5.32 | Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures. ( Bocheva, AI; Dzambazova-Maximova, EB, 2004) |
| "gummosa protected mice against tonic convulsions induced by maximal electroshock (the median effective dose [ED(50)]=198." | 5.31 | Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. ( Kamalinejad, M; Mandgary, A; Sayyah, M, 2002) |
| "The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats." | 5.31 | Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats? ( Haugvicová, R; Kubová, H; Mares, P, 2002) |
| "These results suggest that NPY reduces seizures of hippocampal origin through activation of Y(5) receptors." | 5.31 | Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation. ( Benmaamar, R; Carnahan, J; Depaulis, A; Larmet, Y; Marescaux, C; Nadi, S; Reibel, S, 2001) |
| "Following cocaine-induced seizures, intense c-fos induction was observed in piriform cortex, amygdala, and hippocampus." | 5.31 | Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats. ( Keller, RW; Snyder-Keller, A, 2001) |
| "The ED50 value of AML against clonic seizures induced by PTZ was 5." | 5.31 | Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures. ( Czuczwar, SJ; Kamiński, RM; Kleinrok, Z; Mazurek, M; Turski, WA, 2001) |
| "In MES seizures significant protection was seen with aspirin 100 mg/kg where as higher dose of aspirin 500 mg/kg was required to elicit maximum protection against PTZ seizures." | 5.31 | Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice. ( Gupta, YK; Srivastava, AK, 2001) |
| "alprazolam and ketamine, was tested in two types of seizure activity." | 5.30 | Effect of alprazolam and ketamine on seizures induced by two different convulsants. ( Herink, J, 1997) |
| "rats with a pentylenetetrazole-induced seizure score of 3 or more on a seizure scale ranging from 0 to 6) and death rate compared with those obtained for rats pre-treated with an equivalent intraperitoneal dose (140 mg kg-1) of acepifylline ('equivalent dose' referred to here denotes the theophylline content of the two preparations)." | 5.30 | A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1997) |
| "To determine whether seizures affect GABA(A)-receptor gene transcription in vivo, a transgenic mouse line carrying a lacZ-fusion gene driven by GABA(A)-receptor delta-subunit promoter and upstream sequences was subjected to pentylenetetrazol (PTZ)-induced seizures." | 5.30 | Activation of the GABA(A)-receptor delta-subunit gene promoter following pentylenetetrazole-induced seizures in transgenic mice. ( Crestani, F; Fritschy, JM; Lüscher, B; Penschuck, S, 1997) |
| "Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant." | 5.30 | Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. ( Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV, 1998) |
| "Adenosine has been shown to play a significant role as a modulator of neuronal activity in convulsion disorders, acting as an endogenous anticonvulsant agent." | 5.30 | Time development and regional distribution of [3H]nitrobenzylthioinosine adenosine uptake site binding in the mouse brain after acute Pentylenetetrazol-induced seizures. ( Angelatou, F; Pagonopoulou, O, 1998) |
| "were studied on seizures induced by subcutaneous injection of pentylenetetrazole (PTZ), a widely used antiepileptic screening test believed to model generalized myoclonic seizures." | 5.30 | Antiepileptic effects of NPY on pentylenetetrazole seizures. ( Woldbye, DP, 1998) |
| "In the maximal electroshock seizure threshold test, clobenpropit dose-dependently raised the electroconvulsive threshold for tonic (hindlimb extension) seizures, but a significant increase of about 15% was determined only at the high dose of 40 mg/kg i." | 5.30 | Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice. ( Fischer, W; van der Goot, H, 1998) |
| "Neurologic manifestations, mainly convulsions, are the most frequent extraintestinal complications of shigellosis." | 5.30 | Involvement of tumor necrosis factor alpha and interleukin-1beta in enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae. ( Ashkenazi, S; Kaminsky, E; Shulman, L; Vanichkin, A; Weizman, A; Yuhas, Y, 1999) |
| "The mean convulsion scores were 0." | 5.30 | Role of nitric oxide in the enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae. ( Ashkenazi, S; Balter-Seri, J; Kaminsky, E; Nofech-Mozes, Y; Weizman, A; Yuhas, Y, 1999) |
| "Generalized tonic-clonic seizures were suppressed in all age groups, the three youngest groups being more sensitive than older animals." | 5.30 | The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Mikulecká, A, 1999) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 5.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| " Since several pathophysiological phenomena are common for both ischemia and seizures, we have explored the effect of acute and chronic administration of the adenosine A3 receptor selective agonist IB-MECA (N6-(3-iodobenzyl) adenosine-5'-N-methylcarboxamide) prior to seizures induced by N-methyl-D-aspartate (NMDA), pentamethylenetetrazole, or electric shock." | 5.29 | The effects of adenosine A3 receptor stimulation on seizures in mice. ( Carter, MF; Deutsch, SI; Jacobson, KA; Lin, RC; Mastropaolo, J; Meshulam, Y; Von Lubitz, DK, 1995) |
| "PCP injection had little effect on the seizure susceptibility of older rats." | 5.29 | Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures. ( Moshe, SL; Sircar, R; Veliskova, J, 1994) |
| "Midazolam is a water-soluble benzodiazepine proven to be efficacious in sedation, hypnosis, and induction and maintenance of anesthesia." | 5.29 | Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine. ( Bradford, SM; Orebaugh, SL, 1994) |
| "Nifedipine was found to have anticonvulsant activity in both models but flunarizine only had an anticonvulsant effect in the PTZ seizure incidence/latency test." | 5.29 | Protective effect of flunarizine and nifedipine alone and in combination with anticonvulsant drugs against PTZ-induced seizures in mice. ( Pleuvry, BJ; Rodger, C, 1993) |
| "However, they do not affect clonic seizures with preserved righting reflexes." | 5.29 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester. ( Kusá, R; Mares, P; Roztocilová, L; Velísek, L, 1995) |
| "Occasional, mild seizures occur in NPY-deficient mice and mutants are more susceptible to seizures induced by a GABA (gamma-aminobutyric acid) antagonist." | 5.29 | Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. ( Clegg, KE; Erickson, JC; Palmiter, RD, 1996) |
| "When isbufylline-pretreated rats were challenged with pentylenetetrazole, the EEG was characterized by a short run of wave discharges (whose duration was shorter than that of other groups)." | 5.28 | Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study. ( Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S, 1992) |
| "Tonic-clonic seizures, matched for duration, were induced by MES applied by earclips (40 mA, 1 s) and intraperitoneal injections of PTZ (60 mg/kg); tonic hindlimb extension was present only after MES." | 5.28 | Regional expression of fos-like immunoreactivity following seizures induced by pentylenetetrazole and maximal electroshock. ( Coffey, P; Dean, P; Redgrave, P; Shehab, S, 1992) |
| "Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain." | 5.28 | Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. ( Beal, MF; MacGarvey, U; Miller, J; Vécsei, L, 1992) |
| "PTZ not only induced seizures, but also inhibited specific [3H]FTZ binding to brain membranes in a dose-dependent manner." | 5.28 | Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by L-lysine. ( Chang, YF; Chen, JS; Gao, XM, 1991) |
| "After daily repeated PTZ convulsions, a significant increase of A1 receptors by 26% appeared also in cortex, while the changes of A1 receptors observed in the other brain areas after a single PTZ convulsion were maintained in almost the same range." | 5.28 | Alterations of A1 adenosine receptors in different mouse brain areas after pentylentetrazol-induced seizures, but not in the epileptic mutant mouse 'tottering'. ( Angelatou, F; Kostopoulos, G; Pagonopoulou, O, 1990) |
| "The percentage of convulsions was greater in the kindled mice, compared to controls." | 5.28 | Threshold to elicit seizures by picrotoxin is lowered in pentylenetetrazol-kindled mice. ( Becker, A; Grecksch, G; Matthies, H, 1990) |
| "Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior." | 5.27 | Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984) |
| "Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s." | 5.27 | Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats. ( Mares, P; Velísek, L, 1983) |
| "The onset of seizures was accompanied by a small perturbation of cerebral cortical energy state, but sustained changes were confined to decreases in phosphocreatine, glycogen, and glucose and increases in lactate, pyruvate, and cyclic nucleotides." | 5.27 | Metabolic, circulatory, and structural alterations in the rat brain induced by sustained pentylenetetrazole seizures. ( Folbergrová, J; Ingvar, M; Kalimo, H; Olsson, Y; Siesjö, BK; Söderfeldt, B, 1984) |
| "Three flurothyl convulsions decreased the afterdischarge threshold of the amygdala and enhanced the rate of development of electrical kindling without affecting the intensity of postictal refractoriness." | 5.27 | Unidirectional interaction between flurothyl seizures and amygdala kindling. ( Albala, BJ; Moshé, SL; Okada, R; Ono, K, 1985) |
| "Leptazol B." | 5.24 | Effect of aldosterone and cortisol on leptazol-induced seizures in rats. ( SELLER, MJ; SPECTOR, RG, 1962) |
| " Flurothyl inhalation-induced seizures were as clinically effective as electrical inductions with lesser effects on memory functions." | 4.90 | The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely? ( Cooper, K; Fink, M, 2014) |
| " Though the conventional pentylenetetrazole-induced seizures and electroshock-induced seizures remain the mainstay of any antiepileptic drug screening protocol, considering the diversity of seizure types and underlying pathologies encountered in epilectics, numerous other seizure models have been developed." | 4.80 | METHODS AND CONSIDERATIONS FOR EXPERIMENTAL EVALUATION OF ANTIEPILEPTIC DRUGS. ( George, B; Gupta, YK; Kulkarni, SK; Malhotra, J, 1999) |
| " The present study was conducted to evaluate the effect of probiotic supplementation on pentylenetetrazole (PTZ)-induced seizures in rats." | 4.31 | Electrophysiological, histopathological, and biochemical evaluation of the protective effect of probiotic supplementation against pentylenetetrazole-induced seizures in rats. ( Akin, AT; Aygun, H; Karabulut, D; Kızılaslan, N; Sumbul, O, 2023) |
| "A new series of spiro[indene-1,2'-quinazolin]-4'(3'H)-one derivatives 4a-m were synthesized via a one-pot method and evaluated for anticonvulsant activities using pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures." | 4.31 | Novel spiro[indene-1,2'-quinazolin]-4'(3'H)-one derivatives as potent anticonvulsant agents: One-pot synthesis, in vivo biological evaluation, and molecular docking studies. ( Ahangar, N; Ahdenov, R; Darjani, PS; Larijani, B; Mahdavi, M; Masihi, PH; Mohammadi, AA; Mohammadi-Khanaposhtani, M; Shakiba, A; Shisheboran, S; Taheri, S, 2023) |
| "Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment." | 4.31 | Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023) |
| "05) and STR (42%) and had no effect on pilocarpine-induced seizures." | 4.31 | Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity. ( Adassi, MB; Foutsop, AF; Kom, TD; Ngo Bum, E; Ngoupaye, GT; Yassi, FB, 2023) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 4.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " Seizures were induced in adult mice by sequential injections of a sub-convulsive dose of 35 mg/kg pentylenetetrazole (PTZ) every 48 h to develop the chemical kindling until the mice reached full kindled state (showing three consecutive seizure stages 4 or 5)." | 4.31 | Tonic and phasic stimulations of ventral tegmental area have opposite effects on pentylenetetrazol kindled seizures in mice. ( Fathollahi, Y; Mirnajafi-Zadeh, J; Raoufy, MR; Rezaei, M; Shojaei, A, 2023) |
| " Activation of GPR39 by TC-G 1008 facilitated the development of epileptogenesis in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy." | 4.31 | Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy. ( Barałkiewicz, D; Doboszewska, U; Mlyniec, K; Nieoczym, D; Pieróg, M; Sajnóg, A; Sawicki, J; Socała, K; Sowa, I; Szewczyk, B; Wlaź, P, 2023) |
| " We aimed to evaluate the effect of quercetin on pentylenetetrazole- (PTZ-) induced seizures in male mice focusing on its possible anti-neuroinflammatory and anti-oxidative stress." | 4.31 | Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress. ( Amini-Khoei, H; Korani, MS; Lorigooini, Z; Rahimi-Madiseh, M; Tahmasebi Dehkordi, H; Tavakoli, Z, 2023) |
| "Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic epilepsy models with comorbid neurobehavioral and neuroinflammatory parameters." | 4.31 | Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers. ( Ahmad, T; Alasmari, AF; Alasmari, F; Alqahtani, F; Alqarni, SA; Anjum, SMM; Ashraf, W; Imran, I; Javaid, S; Rasool, MF, 2023) |
| "The aim of this study was to investigate the protective effects of triterpene oleanolic acid on the brain tissue of mice with pentylenetetrazole (PTZ)-induced epileptic seizures." | 4.31 | Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo. ( Akünal Türel, C; Yunusoğlu, O, 2023) |
| " Here, we evaluated its neuroprotective effects at different doses (100 and 200 mg/kg) against pentylenetetrazole (PTZ)-induced seizures." | 4.31 | Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress. ( Dolatshahi, M; Hashemi, P; Karimpour, S; Nazarinia, D, 2023) |
| "Cannabidiol (CBD) is the main active ingredient in the cannabis plant used for treating epilepsy and related diseases." | 4.31 | The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis. ( He, M; Jiang, X; Lu, H; Wang, Q; Wei, M; Zhao, Y, 2023) |
| "To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats." | 4.31 | Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023) |
| " In the present work, BCRP's role as a mechanism that might contribute to drug-resistant epilepsy (DRE) in a mouse model of acute seizures was studied with further assessment of the effect of its inhibition by ko143 and metformin (MET) on lamotrigine (LTG) bioavailability and efficacy." | 4.31 | Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine. ( El-Sayed, NS; Fathelbab, MH; Harby, SA; Khalil, NA; Saleh, SR; Thabet, EH, 2023) |
| " Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures." | 4.31 | Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. ( Antonowski, T; Juranek, J; Podlasz, P; Wiśniewski, K; Wojtkiewicz, J, 2023) |
| "Pentylenetetrazole (PTZ) was administered to induce seizures in a total number of 48 Sprague-Dawley rats." | 4.31 | N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions. ( Azak Pazarlar, B; Bilister Egilmez, C; Erbas, O; Erdogan, MA, 2023) |
| "Using chemogenetics, we evaluated the effect of ANT parvalbumin (PV) neurons on pentylenetetrazole (PTZ)-induced absence seizures in mice." | 4.31 | Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures. ( Jiang, T; Sun, Y; Tuo, M; Wang, J; Wang, Y; Yu, X; Zhang, M; Zhang, X; Zhao, Z, 2023) |
| " Hence, the methanol extract was further explored for its anticonvulsant potential in pentylenetetrazole (PTZ) induced acute seizures in mice." | 4.31 | Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies. ( Arora, S; Kaur, S; Kumar, N; Rajput, A; Sharma, P; Singh Bedi, PM; Singh, B; Singh, H; Singh, S; Singh, T, 2023) |
| " Here, we conducted present study to evaluate its neuroprotective effects against pentylenetetrazole (PTZ)-induced seizures in rats." | 4.31 | (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress. ( Hashemi, P; Moslehi, A; Nazarinia, D, 2023) |
| "In the IP PTZ model, edaravone increased time latencies to seizures (P<0." | 4.31 | Acute and Sub-chronic Anticonvulsant Effects of Edaravone on Seizure Induced by Pentylenetetrazole or Electroshock in Mice, Nitric Oxide Involvement. ( Dastgheib, M; Moezi, L; Oftadehgan, S; Pirsalami, F; Purkhosrow, A; Sattarinezhad, E, 2023) |
| " Experiment 3: ECoG response to anticonvulsant treatment (Phenytoin, Phenobarbital and Diazepam) of seizures induced by association IPDE5 + PTZ." | 4.31 | Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility. ( Azevedo, JEC; de Araujo, DB; de Mello, VJ; Favacho Lopes, DC; Hamoy, AO; Hamoy, M; Martins Rodrigues, JC; Nascimento, CP; Silva, ALMD; Tiago, ACDS; Vieira, LR, 2023) |
| " In this regard, the effects of oxaprozin (OXP) (a nonsteroidal anti-inflammatory drug) on the experimental model of seizure and memory impairment caused by seizures in rats were investigated in the present study." | 4.12 | Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| " Ablation of TRPC3 lessens pilocarpine-induced seizures in mice, suggesting that TRPC3 inhibition might represent a novel antiseizure strategy." | 4.12 | Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. ( Boda, VK; Hou, R; Jiang, J; Li, L; Li, W; Nagib, MM; Wu, Z; Yasmen, N; Yu, Y; Zhang, S, 2022) |
| "Serotonin and fluoxetine, but not sumatriptan, alleviated PTZ-induced seizures by prolonging onset times of myoclonic-jerk and generalized tonic-clonic seizures." | 4.12 | Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats. ( Kilinc, E; Kılınc, YB; Torun, IE, 2022) |
| "The effect of oxaprozin (OXP) on an experimental model of seizures in rats was investigated in this study." | 4.12 | Anticonvulsant activity of oxaprozin in a rat model of pentylenetetrazole-induced seizure by targeting oxidative stress and SIRT1/PGC1α signaling. ( Bananej, M; Khatami, P; Khosravi, M; Mirazi, N, 2022) |
| "Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory." | 4.12 | Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage. ( Emik, S; Sahin, H; Senturk, GE; Yucel, O, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 4.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| " After 24 h, CCI-injured rats received intraperitoneal injection of pentylenetetrazole 35 mg/kg once every other day until acquisition of generalized seizures." | 4.12 | Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats. ( Choopani, S; Pourbadie, HG; Radpour, M; Sayyah, M, 2022) |
| "Morin is a bioactive flavonoid with prominent neuroprotective potentials, however, its impact on epilepsy-provoked cognitive dysregulations has not been revealed." | 4.12 | Morin offsets PTZ-induced neuronal degeneration and cognitive decrements in rats: The modulation of TNF-α/TNFR-1/RIPK1,3/MLKL/PGAM5/Drp-1, IL-6/JAK2/STAT3/GFAP and Keap-1/Nrf-2/HO-1 trajectories. ( Abd El-Aal, SA; Abulfadl, YS; El-Abhar, HS, 2022) |
| " Conversely, higher dose of anandamide, AM404, URB597 (100 µg/mouse) as well as capsaicin (a TRPV1 agonist: 1, 10, or 100 µg/mouse) attenuated the protective effect of diazepam against PTZ-induced seizures." | 4.12 | Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice. ( Manna, SSS, 2022) |
| " In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects." | 4.12 | Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022) |
| " The compound had a pronounced anticonvulsant effect, significantly reducing the mortality of mice in models of seizures induced by pentylenetetrazole, picrotoxin, strychnine, and caffeine." | 4.12 | Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico. ( Georgiyants, V; Kayal, WE; Mishchenko, M; Severina, H; Shtrygol, D; Shtrygol, S; Zalevskyi, S, 2022) |
| " This study investigated the effects and mechanisms of compound 48/80-stimulated mast cell activation on pentylenetetrazole-induced epileptic seizures in rats." | 4.12 | Mast cell activation ameliorates pentylenetetrazole-induced seizures in rats: The potential role for serotonin. ( Cetinkaya, A; Kilinc, E; Tore, F; Torun, IE, 2022) |
| " In this study, the effect of antidepressant sertraline (SRT) in combination with AEDs sodium valproate (SV) and levetiracetam (LEV) on seizures, cognitive impairment and oxidative stress in rats was evaluated." | 4.02 | Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats. ( Hussain, M; Katyal, J; Rashid, H, 2021) |
| " OV329, a novel drug candidate for the treatment of epilepsy and addiction, has been shown in vitro to be substantially more potent as a GABA-AT inactivator than vigabatrin, an antiseizure drug approved as an add-on therapy for adult patients with refractory complex partial seizures and monotherapy for pediatric patients with infantile spasms." | 4.02 | OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats. ( Deking, LS; During, MJ; Feja, M; Gernert, M; Kaczmarek, E; Meller, S; Silverman, RB, 2021) |
| " Mice in CSA exhibited electroencephalography (EEG) patterns distinct from kainic acid-induced SE and PTZ alone, clearly differentiating CSA from SE and PTZ-induced myoclonic seizures." | 4.02 | Continuous seizure emergency evoked in mice with pharmacological, electrographic, and pathological features distinct from status epilepticus. ( Barker-Haliski, M; Knox, KM; White, HS; Zierath, DK, 2021) |
| " Therefore, the present study hypothesized an antiepileptic potential of chondroitin sulfate (CS) in pentylenetetrazole-induced kindled epilepsy and pilocarpine-induced status epilepticus in mice." | 4.02 | Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice. ( Abdel-Daim, MM; Almeer, R; Kamel, M; Najda, A; Nurzyńska-Wierdak, R; Singh, M; Singh, S; Singh, TG, 2021) |
| "We aimed to reveal the anti-convulsant effects sulfasalazine and its mechanism in pentylenetetrazole (PTZ)-induced seizures in rats." | 4.02 | The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats. ( Akyol, PY; Bora, ES; Erbaş, O; Karaali, R; Yurtsever, G, 2021) |
| "In spite of use of cannabidiol (CBD), a non-psychoactive cannabinoid, in pediatric patients with epilepsy, preclinical studies on its effects in immature animals are very limited." | 4.02 | Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats. ( Hložek, T; Kubová, H; Mareš, P; Páleníček, T; Uttl, L, 2021) |
| " In this study, it was aimed to investigate the effect of pantoprazole on pentylenetetrazole-induced epileptic seizures in rats and neurotoxicity in the SH-SY5Y cell line." | 4.02 | The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line. ( Ergul, M; Gunes, H; Ozdemir, E; Ozturk, A; Sahin, B; Taskiran, AS, 2021) |
| " Our data showed that micronized resveratrol decreased the occurrence of the tonic-clonic seizure stage and slowed the development of the seizures in a similar manner of diazepam." | 4.02 | Micronized Resveratrol Shows Anticonvulsant Properties in Pentylenetetrazole-Induced Seizure Model in Adult Zebrafish. ( Aguiar, GPS; Almeida, ER; Decui, L; Garbinato, C; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Schneider, SE; Siebel, AM, 2021) |
| "LMR-101 is a bisphenol derivative of propofol, a short-acting general anesthetic, which is also used to manage status epilepticus (SE)." | 4.02 | LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors. ( An, L; Chen, T; Guo, S; Huang, X; Liu, L; Mei, Q; Sun, X; Tian, H; Wang, R; Zhao, Y, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 4.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " The seizures were induced with pentylenetetrazole (PTZ) intraperitoneally at 170 mg/kg, and diazepam (DZP) was used as the control anticonvulsant (2 mg/kg, oral); PA was tested at 10, 50, and 100 mg/kg orally." | 4.02 | Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. ( Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL, 2021) |
| " Some antiseizure drugs (ASDs) have been shown to produce discrepant results in larvae and adults zebrafish, therefore, their anticonvulsant efficacy in subsequent stages of the pentylenetetrazole (PTZ)-induced seizures should be more precisely characterized." | 4.02 | Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish. ( Doboszewska, U; Guz, L; Pieróg, M; Poleszak, E; Serefko, A; Socała, K; Szopa, A; Wlaź, P; Wyska, E, 2021) |
| " In the pentylenetetrazole-induced seizure model, 1, 5, or 10 mg/kg vortioxetine demonstrated a significant dose-dependent decrease in mean spike frequency, an increase in the latency to minor and major seizures, and a decrease in total duration of major seizure and convulsion stage." | 4.02 | Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats. ( Aygun, H; Ayyildiz, M, 2021) |
| " We examined the effect of these metabolites on the threshold of clonic seizures induced by pentylenetetrazole (PTZ)." | 4.02 | The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors. ( Ghanbari, MM; Loron, AG; Sayyah, M, 2021) |
| " Impact of AdCA on (1) threshold and occurrence of clonic seizures induced by pentylenetetrazole (PTZ) in mice, (2) incidence of tonic seizures induced by maximal electroshock (MES) in mice, and (3) incidence of generalized seizures and duration of evoked afterdischarges in amygdala-kindled rats, were determined." | 4.02 | Anti-Seizure Activity of 1-Adamantane Carboxylic Acid in Common Experimental Seizure Models: Role of Benzodiazepine-GABAA Receptors. ( Gavzan, H; Ghanbari, E; Khoshkroodian, B; Sayyah, M, 2021) |
| " The study looked at how the thiamine supplement impacted pentylenetetrazole (PTZ)-induced seizures in rats and pentylenetetrazole-induced neurotoxicity in the SH-SY5Y cell line." | 4.02 | The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. ( Ergul, M; Taskiran, AS, 2021) |
| " In the present study, we evaluated data from one of the largest global databases to identify drugs with antiepileptic effects, and subsequently attempted to understand the effect of the combination of antiepileptic drugs and valacyclovir in epileptic seizures using a kindling model." | 4.02 | Examination of the antiepileptic effects of valacyclovir using kindling mice- search for novel antiepileptic agents by drug repositioning using a large medical information database. ( Chuma, M; Goda, M; Horinouchi, Y; Ikeda, Y; Imanishi, M; Ishizawa, K; Izawa-Ishizawa, Y; Jozukuri, N; Niimura, T; Takahashi, S; Takechi, K; Tsuchiya, K; Yanagawa, H; Zamami, Y, 2021) |
| " citratus essential oil (EO) and hydroalcoholic extract (E1) from its leaves, as well as of its related compounds citral (CIT) and geraniol (GER) against the effects of pentylenetetrazole (PTZ) induced seizures in zebrafish (Danio rerio)." | 4.02 | Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish. ( Hacke, ACM; Marques, JA; Miyoshi, E; Pereira, RP, 2021) |
| "This study explored the role of succinate accumulation in the oxidative stress and iron accumulation in both pentylenetetrazol (PTZ)-induced epileptogenesis and kainic acid (KA)-induced status epilepticus (SE)." | 4.02 | Succinate accumulation contributes to oxidative stress and iron accumulation in pentylenetetrazol-induced epileptogenesis and kainic acid-induced seizure. ( Cheng, Y; Cui, Y; Huang, W; Li, S; Liu, W; Sun, H; Xin, W; Zhang, M; Zhang, Y; Zhu, W, 2021) |
| " Adaptation of zebrafish to study seizures was initially established using the common convulsant agent pentylenetetrazole (PTZ)." | 4.02 | A zebrafish-centric approach to antiepileptic drug development. ( Baraban, SC, 2021) |
| " In this study, the pentylenetetrazole seizure test (PTZ) was performed to assess the effectiveness of four new ASDs: lamotrigine (LTG), topiramate (TPM), felbamate (FBM), and levetiracetam (LEV) in the subsequent stages of seizures in adult fish." | 4.02 | Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish. ( Doboszewska, U; Guz, L; Pieróg, M; Poleszak, E; Serefko, A; Socała, K; Szopa, A; Wlaź, P; Wyska, E, 2021) |
| " We investigated effects of long-term probiotics supplementation on epileptic seizures, and inflammatory and oxidant/antioxidant biomarkers in a pentylenetetrazole(PTZ)-induced seizure model in rats." | 4.02 | Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats. ( Ankarali, H; Ankarali, S; Ayhan, D; Cetinkaya, A; Kilinc, E; Torun, IE, 2021) |
| " ES was applied bilaterally to the amygdala in animals subjected to the pentylenetetrazole continuous infusion (10 mg/ml/min) model, myoclonic or tonic-clonic generalized seizures were triggered." | 4.02 | Survival analysis of nonperiodic stimulation (NPS) performance. ( Batista Tsukahara, VH; Cota, VR; de Oliveira, JC; Maciel, CD, 2021) |
| " In pentylenetetrazole-induced acute seizures only BUM532 combined with a sub-effective dose of PB increased the seizure threshold." | 3.96 | Functional characterization of novel bumetanide derivatives for epilepsy treatment. ( Auer, T; Erker, T; Schreppel, P; Schwarzer, C, 2020) |
| " Importantly, the isobolographic analysis showed that a combination of AS-1 and valproic acid (VPA) at the fixed ratio of 1:1 displayed a supra-additive (synergistic) interaction against PTZ-induced seizures in mice." | 3.96 | N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug. ( Abram, M; Andres-Mach, M; Esguerra, CV; Gawel, K; Jakubiec, M; Kamiński, K; Latacz, G; Lubelska, A; Nieoczym, D; Pieróg, M; Rapacz, A; Socała, K; Szewczyk, A; Szulczyk, B; Wlaź, P; Zagaja, M; Łuszczki, JJ, 2020) |
| " In this study we show that low-dose intranasal insulin inhibited kainic acid (KA)- or pentylenetetrazole (PTZ)-induced acute seizures and reduced epileptic discharge activities in mice, potentially by alleviating the increase in seizure-induced glutamate in the hippocampus." | 3.96 | Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy. ( Fan, Y; Hou, C; Jiang, G; Peng, S; Tang, F; Wang, X; Wang, Y; Yang, J; Yu, J, 2020) |
| "The aim of the present study was to investigate the effect of rutin administration (100 mg/kg/day) to pentylenetetrazol (PTZ)-treated Balb-c mice (60 mg/kg/day), with respect to anxiety-like behavior using both open-field and elevated plus-maze (EPM) tests, and acetylcholinesterase (AChE) activity in salt-soluble (SS) fraction and detergent-soluble (DS) fraction of the cerebral cortex, hippocampus, striatum, midbrain, and diencephalon." | 3.96 | Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice. ( Anesti, M; Atsopardi, K; Lamari, FN; Margarity, M; Panagopoulos, NT; Stavropoulou, N, 2020) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| " The extracts were evaluated for antiseizure activity using a larval zebrafish epilepsy model with pentylenetetrazole (PTZ)-induced seizures." | 3.96 | Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles. ( Brillatz, T; Crawford, AD; Houriet, J; Jacmin, M; Kalpoutzakis, E; Marcourt, L; Pellissier, L; Petrakis, EA; Queiroz, EF; Rutz, A; Skaltsounis, AL; Vougogiannopoulou, K; Wolfender, JL, 2020) |
| "Adult zebrafish were repeatedly exposed to subeffective concentrations of pentylenetetrazole (PTZ), until appearance to tonic-clonic seizures, considered as kindled." | 3.96 | Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents. ( Kumari, S; Mazumder, AG; Rana, AK; Sharma, P; Sharma, S; Singh, D, 2020) |
| " The main goal of the current study is to investigate the possible anticonvulsant effect of selenium nanoparticles (SeNPs) against pentylenetetrazole (PTZ)-mediated epileptic seizures in mice hippocampus." | 3.96 | Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice. ( Abdel Moneim, AE; Al-Ghamdy, AO; Alkandiri, A; Fu, Z; Guo, L; Habotta, OA; Ji, P; Kassab, RB; Yuan, X, 2020) |
| " This study aimed to investigate the effect of sCT on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole (PTZ)-induced epilepsy model in rats." | 3.96 | The effects of salmon calcitonin on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole-induced epilepsy model in rats. ( Ergul, M; Gumus, E; Ozdemir, E; Taskıran, AS, 2020) |
| " In the earlier work, 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine demonstrated anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.96 | In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. ( Askani, M; Malhi, SM; Nisar, U; Shaheen, F; Shahid, M; Simjee, SU, 2020) |
| "To investigate the neuroprotective effect of ferulic acid (FA) in a pentylenetetrazol (PTZ)-induced seizures model in rat, the motor response, spatial learning ability and memory capability of the rats were assessed." | 3.91 | Ferulic acid ameliorates pentylenetetrazol-induced seizures by reducing neuron cell death. ( Hu, Q; Liu, D; Wang, S; Zhang, SH; Zhou, S; Zhu, J, 2019) |
| "These findings suggest that the combination of 5-FU and cefepime exacerbates early-onset convulsive seizures and elicits delayed-onset convulsive status epilepticus." | 3.91 | 5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice. ( Aso, H; Suemaru, K; Watanabe, M; Yoshikawa, M, 2019) |
| " In addition, Salubrinal, an ER stress inhibitor, was used as a positive control, and exhibited neuroprotective effects via inhibiting excessive ER stress in the seizure model, which further supported that the inhibition in ER stress by VPA treatment could exert neuroprotection in seizures." | 3.91 | Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress. ( Chen, TC; Chen, Y; Fu, J; He, H; Peng, L; Wang, W; Zeng, S, 2019) |
| "We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1β) in pentylenetetrazol-induced seizures in rats." | 3.91 | Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats. ( Gunes, H; Kilinc, E, 2019) |
| " This study evaluated the efficacy of sodium valproate encapsulated in nanoparticles in pentylenetetrazole (PTZ) induced acute and kindling models of seizures in male Wistar rats." | 3.91 | Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models. ( Dinda, AK; Gupta, YK; Kottarath, SK; Meenu, M; Reeta, KH, 2019) |
| "Larval movement times and total distances traveled by zebrafish larvae experiencing pentylenetetrazole (PTZ)-induced seizures were decreased by valproate treatment." | 3.91 | Rongchang and Xifeng capsules suppress pentylenetetrazole-induced seizures and change rest/wake behavior in zebrafish larvae. ( Chen, D; Dai, L; Fang, Y; Feng, D; Feng, X; He, X; Kuang, X; Wang, C; Xu, J; Zhang, S; Zhu, S, 2019) |
| " The present study was designed to investigate the effect of acute and chronic administration of thiamine alone and in combination with sub-effective dose of diazepam on pentylenetetrazole (PTZ)-induced tonic-clonic seizures in mice." | 3.91 | Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. ( Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A, 2019) |
| " This study was designed to investigate whether acute treatment with boldine could alter seizures induced by pentylenetetrazole or electroshock in mice." | 3.91 | Acute Boldine Treatment Induces Anti-convulsant Effects in Mice through its Antioxidant Activity. ( Jamshizadeh, A; Moezi, L; Pirsalami, F; Yahosseini, S, 2019) |
| " The present study was designed to evaluate the effect of arbutin supplementation on seizures behavior, memory performance, glial activation, release of inflammatory factors and neuroprotection in pentylenetetrazole-induced kindling model." | 3.91 | Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy. ( Ahmadian, SR; Ghasemi-Kasman, M; Pouramir, M; Sadeghi, F, 2019) |
| " Seizures were induced in 3-week old rats by a single injection of pentylenetetrazole (PTZ)." | 3.91 | Transient Switching of NMDA-Dependent Long-Term Synaptic Potentiation in CA3-CA1 Hippocampal Synapses to mGluR ( Ergina, JL; Kalemenev, SV; Postnikova, TY; Trofimova, AM; Zaitsev, AV; Zubareva, OE, 2019) |
| "The use of losartan with sodium valproate in epilepsy may prevent the cognitive and cardiac sequelae of seizures." | 3.91 | Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats. ( Arava, S; Gupta, YK; Joshi, D; Katyal, J, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| " The aim of this study was evaluating as well as comparing the effects of rubidium chloride (RbCl) and lithium chloride (LiCl) on different seizures paradigms in mice and determining the involvement of NMDA receptors and nitrergic pathway." | 3.91 | Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium. ( Bahramnejad, E; Dehpour, AR; Faghir-Ghanesefat, H; Hassanipour, M; Pourshadi, N; Rahimi, N; Yarmohammadi, F, 2019) |
| " The present study aimed to investigate the anticonvulsant effects of Senna spectabilis decoction on seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ), pilocarpine (PC) and its possible action mechanisms in animal models using flumazenil (FLU), methyl-ß-carboline-3-carboxylate (BC) and bicuculline (BIC)." | 3.88 | Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock. ( Josiane Ojong, L; Jules Fifen, J; Kameni Njapdounke, JS; Kavaye Kandeda, A; Ngo Bum, E; Nkamguie Nkantchoua, GC; Sotoing Taiwe, G, 2018) |
| "The underlying mechanisms for the neuroprotective effects of lithium chloride in neurodegenerative diseases such as seizures remain unknown." | 3.88 | The anticonvulsant activity and cerebral protection of chronic lithium chloride via NMDA receptor/nitric oxide and phospho-ERK. ( Dehpour, AR; Ejtemaei Mehr, S; Esmaeili, J; Ghahremani, MH; Mohammad Jafari, R; Rahimi, N; Rashidian, A; Shadboorestan, A, 2018) |
| " Eighty-four male Balb/C mice were divided into 7 groups: control-naïve, pentylenetetrazole (PTZ)-induced seizures, PTZ-calcitonin, PTZ-valproic acid, PTZ-pregabalin, PTZ-calcitonin-valproic acid (PCV) combination, and PTZ-calcitonin-pregabalin (PCP) combination." | 3.88 | Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice. ( Ashour, RH; El-Beltagi, HM; Hamada, NM; Shalaby, AA, 2018) |
| "The aim of this study is to investigate the therapeutic effects of vitamin U (Vit U) on lung tissue of pentyleneterazole (PTZ)-induced seizures in rats." | 3.88 | The effect of vitamin U on the lung tissue of pentyleneterazole-induced seizures in rats. ( Alev, B; Bayrak, G; Emekli-Alturfan, E; Ipekci, H; Oktay, S; Pisiriciler, R; Tunali-Akbay, T; Turkyilmaz, IB; Ustundag, UV; Yanardag, R; Yarat, A, 2018) |
| " Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures." | 3.88 | Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs. ( Araki, H; Aso, H; Suemaru, K; Tanaka, A; Watanabe, M; Yoshikawa, M, 2018) |
| " For in-vivo study, seizures were induced in Wistar rats (200-225g) by pentylenetetrazole (PTZ) and maximal-electroshock." | 3.88 | Protective effect of Terminalia chebula against seizures, seizure-induced cognitive impairment and oxidative stress in experimental models of seizures in rats. ( Agarwal, A; Arora, R; Gupta, YK; Kumar, R, 2018) |
| " Here, we investigated whether embryonic exposure to ethanol can increase the susceptibility to pentylenetetrazole (PTZ)-induced seizures in larval zebrafish." | 3.88 | Embryonic exposure to ethanol increases the susceptibility of larval zebrafish to chemically induced seizures. ( Cai, L; Chen, SY; Chen, X; Feng, W; Liu, J; Wang, K; Wu, X; Zou, LP, 2018) |
| "Pentylenetetrazole (PTZ)-induced seizures in Zebrafish models are now widely accepted for investigating human disease epilepsy." | 3.88 | Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish. ( Cui, Y; Han, L; He, Q; Jin, M; Liu, K; Zhang, S, 2018) |
| " Therefore, hippocampal Pol1 activity was examined in mouse models of epilepsy including kainic acid- and pilocarpine-induced status epilepticus (SE) as well as a single seizure in response to pentylenetetrazole (PTZ)." | 3.88 | RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. ( Hetman, M; Kolikonda, M; Naik, SP; Parlato, R; Pietrzak, M; Slomnicki, LP; Smith, SC; Vashishta, A, 2018) |
| " The aim of the present study was to explore the effect of a selective CB2 receptor agonist β-caryophyllene (BCP) in models of seizures and cognition in mice." | 3.88 | Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice. ( da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R, 2018) |
| " marinoi was extracted by solvents with increasing polarities (hexane, dichloromethane, methanol and water) and these extracts were screened for anticonvulsant activity using a larval zebrafish epilepsy model with seizures induced by the GABAA antagonist pentylenetetrazole." | 3.88 | Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi. ( Brillatz, T; Crawford, AD; Esposito, F; Ianora, A; Jacmin, M; Khamma, S; Lauritano, C; Marcourt, L; Queiroz, EF; Righi, D; Romano, G; Wolfender, JL, 2018) |
| " The aim of this study was to evaluate the effects of corilagin, an ellagitannin extracted from medicinal plants, on the frequency of seizures and cognitive function in a rat model of chronic epilepsy." | 3.88 | Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy. ( Chang, LY; Wei, LL; Yu, H; Yu, X; Zhou, T, 2018) |
| " We investigated probable involvement of PPARα in the anticonvulsant effect of DHA in pentylenetetrazole (PTZ) model of clonic seizures." | 3.88 | A role for peroxisome proliferator-activated receptor α in anticonvulsant activity of docosahexaenoic acid against seizures induced by pentylenetetrazole. ( Babaei, J; Gavzan, H; Hashemi, F; Sayyah, M, 2018) |
| " Accordingly, the aim of this study is to determine if coenzyme Q10 (CoQ10) and alpha-tocopherol (α-Toc) have a neuroprotective effect in rats against the observed oxidative stress and inflammation during seizures induced by pentylenetetrazole (PTZ) in rats, and to study their interactions with the conventional antiseizure drug phenytoin (PHT), either alone or in combination." | 3.88 | Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways. ( Al-Khalek, HAA; Khalifa, AE; Masoud, SI; Nagib, MM; Rahmo, RM; Sabri, NA; Tadros, MG, 2018) |
| "Curcumin, derived from turmeric, has been demonstrated to be effective in controlling seizures, although the exact mechanism is yet unknown." | 3.88 | The role of serotonin and its receptors on the anticonvulsant effect of curcumin in pentylenetetrazol-induced seizures. ( Amin, B; Arbabi Jahan, A; Ghanbarabadi, M; Mohammad-Zadeh, M; Rad, A, 2018) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " Treatment with the high dose of naringin (80 mg/kg) along with phenytoin has shown to offer protection against seizures, development of kindling, and cognition enhancement through Y-maze test and improved % conditioned avoidance response (% CAR) through pole climbing test in pentylenetetrazole (PTZ)-induced kindling model." | 3.88 | Naringin in a combined therapy with phenytoin on pentylenetetrazole-induced kindling in rats. ( Akula, A; Danduga, RCSR; Ineedi, S; Kola, PK; Mohammad, A; Nissankara Rao, LS, 2018) |
| "The effects of tamoxifen and soy on apoptosis of the hippocampus and dentate gyrus of ovariectomized rats after repeated seizures were investigated." | 3.88 | The effects of soy and tamoxifen on apoptosis in the hippocampus and dentate gyrus in a pentylenetetrazole-induced seizure model of ovariectomized rats. ( Ataei, ML; Ebrahimzadeh-Bideskan, AR; Hosseini, M; Jahanshahi, M; Mansouri, S, 2018) |
| " In the present study, we investigated the effect of genistein on pentylenetetrazole-induced seizures in ovariectomized mice and the possible involvement of estrogenic and serotonergic pathways in the probable effects of genistein." | 3.85 | Genistein modulation of seizure: involvement of estrogen and serotonin receptors. ( Algazo, M; Alshaib, H; Amiri Gheshlaghi, S; Dehpour, AR; Mohammad Jafari, R; Rahimi, N, 2017) |
| "In view of well-evidenced antiepileptic effects of melatonin and few reports of anticonvulsant action of agomelatine, the present study investigated whether agomelatine protects against pentylenetetrazole (PTZ)-induced kindling in mice and kindling-associated oxidative stress, depression, and impairment of spatial memory." | 3.85 | Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine. ( Agarwal, NB; Azim, MS; Vohora, D, 2017) |
| " In contrast, impaired performance in the Morris water maze test and decreased anxiety-like behavior persisted together with an increased susceptibility to pentylenetetrazole-induced seizures suggesting alterations in neural activity patterns." | 3.85 | Traumatic brain injury causes long-term behavioral changes related to region-specific increases of cerebral blood flow. ( Angenstein, F; Goldschmidt, J; Hummel, R; Pöttker, B; Radyushkin, K; Schäfer, MKE; Stöber, F, 2017) |
| "For the anticonvulsant experiment lamotrigine dose-dependently suppressed pentylenetetrazole-induced seizures." | 3.85 | Effect of lamotrigine on seizure development in a rat pentylenetetrazole kindling model. ( Chen, Y; Fang, Z; He, X; Sun, Q; Zhou, L, 2017) |
| "We induced generalized tonic-clonic seizures with the administration of 60 mg/kg pentylenetetrazole (PTZ) in male Wistar Albino rats." | 3.85 | The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model. ( Ateş, N; Dede, F; Eraldemir, FC; Karadenizli, S; Özsoy, ÖD; Şahin, D, 2017) |
| " 24h later, animals were subjected to seizures by using either maximal electro shock or pentylenetetrazole." | 3.85 | Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides. ( Chakrabarti, A; Medhi, B; Modi, M; Saikia, UN; Sewal, RK, 2017) |
| " The effects of TNS (3-hour session; 30-s ON, 5-min OFF; 30Hz; 500μs; 2mA) were evaluated on: (i) behavioral pattern of pentylenetetrazole (PTZ)-induced seizures as measured by the Racine scale; (ii) c-Fos-like immunoreactivity in discrete brain areas; (iii) hippocampal cell proliferation by bromodeoxyuridine (BrdU)-like immunoreactivity." | 3.85 | Trigeminal nerve stimulation induces Fos immunoreactivity in selected brain regions, increases hippocampal cell proliferation and reduces seizure severity in rats. ( Boi, M; Deriu, F; Enrico, P; Floris, G; Follesa, P; Mercante, B; Quartu, M; Serra, MP, 2017) |
| " In the present study, we determined the effect of repeated restraint stress exposure on the susceptibility of pentylenetetrazole (PTZ)-induced seizures and the possible mechanisms involved using a rodent model." | 3.85 | Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress. ( Chao, J; Dong, J; Xia, Z; Yao, H; Zhang, A; Zhu, X, 2017) |
| " The role of MAC in oxidative stress and inflammation after pentylenetetrazole (PTZ)-induced kindling was investigated by measuring reactive oxygen species (ROS) production, superoxide dismutase (SOD), and catalase (CAT) activities, nitrite content, and deoxyribonucleic acid (DNA) damage in cerebral cortex." | 3.85 | Manual acupuncture improves parameters associated with oxidative stress and inflammation in PTZ-induced kindling in mice. ( Coelho, VR; da Silva, JB; da Silva, LL; de Souza, MS; Frantz, AL; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Saffi, J; Viau, CM, 2017) |
| " Ferulic acid is a phenolic phytochemical with antioxidant and neuroprotective properties that prompted us to evaluate its therapeutic potential in epilepsy which is usually associated with oxidative stress and cognitive decline." | 3.85 | Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy. ( Arbabi, E; Atyabi, F; Dinarvand, R; Hassanzadeh, P, 2017) |
| " Anticonvulsant activity was tested against clonic seizures induced by pentylenetetrazole (PTZ, 60 mg/kg, i." | 3.85 | In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures. ( Gharibi Loron, A; Narenjkar, J; Sardari, S; Sayyah, M, 2017) |
| "In this study, the effects of levosimendan on seizure susceptibility was studied by PTZ-induced seizures model in mice." | 3.85 | Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for K ( Aleyasin, AR; Amini-Khoei, H; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Mojahedi, P; Tabaeizadeh, M; Vafaei, A; Yousefi, F, 2017) |
| " Here, we found that gastrodin ameliorated pentylenetetrazole (PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice." | 3.85 | Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice. ( Chen, L; Liu, X; Qu, M; Wang, H, 2017) |
| " Owing to the major role of neuronal nitric oxide synthase (nNOS) in brain and ineffectiveness of antiepileptic drugs (AEDs) in restoring nitrosative stress, the present study was envisaged to evaluate the adjuvant nNOS inhibitor, 7-nitroindazole (7-NI) with valproic acid for combined treatment of epilepsy and associated depression." | 3.85 | Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2017) |
| " We investigated the effects of oleuropein on pentylenetetrazole (PTZ)-induced seizures in male NMRI mice, with diazepam as the standard drug." | 3.85 | Effects of oleuropein on pentylenetetrazol-induced seizures in mice: involvement of opioidergic and nitrergic systems. ( Dehpour, AR; Delfan, B; Motamed-Gorji, N; Rahimi, N, 2017) |
| " Based on previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish." | 3.85 | Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish. ( Bernabeu, R; Bruno-Blanch, L; Otero, S; Pisera-Fuster, A; Talevi, A, 2017) |
| "The present study investigated the effects of ferulic acid (FA) on pentylenetetrazole (PTZ)-induced seizures, oxidative stress markers (malondialdehyde (MDA), catalase, and reduced glutathione (GSH)), connexin (Cx) 43, heat shock protein 70 (Hsp 70), and monoamines (serotonin (5-HT) and norepinephrine (NE)) levels in a rat model of PTZ-induced kindling." | 3.85 | Effects of ferulic acid on oxidative stress, heat shock protein 70, connexin 43, and monoamines in the hippocampus of pentylenetetrazole-kindled rats. ( Abbas, KM; Abulseoud, OA; El-Hussainy, EMA; Hussein, AM, 2017) |
| " The rats were decapitated at the 24th or 72nd hour of seizures and brain tissues were obtained for histopathological examination and for measuring levels of malondialdehyde (MDA), glutathione (GSH), reactive oxygen radicals and myeloperoxidase (MPO) activity." | 3.85 | Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure. ( Akakın, D; Atal, SS; Kervancıoğlu Demirci, E; Koyuncuoğlu, T; Üren, D; Vızdıklar, C; Yeğen, BÇ; Yıldırım, Ç; Yılmaz, H; Yüksel, M, 2017) |
| " Seizures were induced with one of Pentelyntetrazole (PTZ), 4-Aminopyridine (AP) and Strychnine (STR)." | 3.85 | Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats. ( Desalu, OO; Kolo, PM; Olarinoye, JK; Olatunji, LA; Sanya, EO; Soladoye, AO, 2017) |
| " The present study was designed to investigate synergistic anticonvulsant effects of pregabalin with amlodipine on acute seizure model of epilepsy in mice." | 3.85 | Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice. ( Khan, RA; Qureshi, IH; Riaz, A; Siddiqui, AA, 2017) |
| "Folic acid (FA) is physiologically important in mammals and is a common vitamin supplement used during pregnancy and lactation." | 3.83 | Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant- and prepubertal rats after pentylenetetrazole-induced seizure. ( Caglayan, B; Kaptan, E; Oztas, B; Seker, FB; Yorulmaz, H, 2016) |
| "Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice." | 3.83 | Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205. ( Anisimova, VA; Grechko, OY; Kalitin, KY; Spasov, AA, 2016) |
| " The initial anticonvulsant screening was performed in mice (ip) using the 'classical' maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests as well as in the six-Hertz (6Hz) model of pharmacoresistant limbic seizures." | 3.83 | New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones. ( Abram, M; Andres-Mach, M; Kamiński, K; Obniska, J; Rapacz, A; Zagaja, M; Łuszczki, JJ, 2016) |
| " In addition to anxiety and depressive-like behaviors, we previously showed that juvenile SIS increases susceptibility to pentylenetetrazole (PTZ)-induced seizures in mice through enhancing the nitrergic system activity in the hippocampus." | 3.83 | NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice. ( Amini-khoei, H; Amiri, S; Azizi, R; Dehpour, AR; Ghazi-Khansari, M; Haj-Mirzaian, A; Mehr, SE; Momeny, M; Rahimi-Balaei, M; Shirzadian, A; Zarrinrad, G, 2016) |
| " This study was conducted to investigate whether or not triamterene, a K(+)-sparing diuretic, can generate protection against seizures induced by intravenous or intraperitoneal pentylenetetrazole (PTZ) models." | 3.83 | A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice. ( Almasirad, A; Barati, S; Ghasemi, M; Moezi, L; Shafaroodi, H, 2016) |
| "A number of acridone-based oxadiazoles 11a-n have been synthesized and evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ)- and maximal electroshock (MES)-induced seizures in mice." | 3.83 | Design, synthesis, pharmacological evaluation, and docking study of new acridone-based 1,2,4-oxadiazoles as potential anticonvulsant agents. ( Aghaei, I; Akbarzadeh, T; Emami, S; Faizi, M; Foroumadi, A; Jahani, R; Mahdavi, M; Mohammadi-Khanaposhtani, M; Shabani, M; Shafiee, A; Shamsaei Zafarghandi, N; Sharafi, Z, 2016) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 3.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| " All the synthesized title derivatives were assessed for in vivo anticonvulsant screening by the two most employed standard animal seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ)-induced seizures, along with minimal motor impairment screening by rotarod test." | 3.83 | Design, Synthesis, and Biological Evaluation of 6-(2-Amino-substituted phenyl)-4-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Anticonvulsant Agents. ( Akhtar, MJ; Ali, Z; Khan, AA; Siddiqui, N; Yar, MS, 2016) |
| "Our findings indicate that the administration of nicotine may attenuate microglial activity and increase eclampsia-like seizure threshold in rat hippocampus through the α7 nicotinic receptor." | 3.83 | Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor. ( Bao, J; Han, X; Li, X; Liu, H; Liu, Y; Thakur, M; Ye, A, 2016) |
| " In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically altered uric acid levels by targeting urate oxidase, which is the enzyme responsible for uric acid breakdown." | 3.83 | Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice. ( Boon, P; Carrette, E; Delbeke, J; Glorieux, G; Larsen, LE; Portelli, J; Raedt, R; Sprengers, M; Thyrion, L; Van Lysebettens, W; Vonck, K, 2016) |
| " Changes in breathing and cardiac electrical activity in DBA/1 and C57BL/6J mice that incurred sudden death during generalized seizures evoked by pentylenetetrazole (PTZ) were studied by plethysmography and electrocardiography." | 3.83 | 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. ( Cotten, JF; Feng, HJ; Xue, Q; Yang, X; Zhang, H; Zhao, H, 2016) |
| "The new N-Mannich bases were effective in maximal electroshock or pentylenetetrazole seizures screens; and the most interesting compound 4 (1-{[4-(1-phenyethyl)-piperazin-1-yl]methyl}-3',4'-dihydro-1'H,2H,5H-spiro[imidazolidine-4,2'-naphthalene]-2,5-dione) displayed anticonvulsant activity in both the aforementioned tests." | 3.83 | Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin. ( Bednarski, M; Byrtus, H; Czopek, A; Kazek, G; Pawłowski, M; Sapa, J; Siwek, A; Zagórska, A, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The present study aimed to develop a neurochemistry-based single or adjuvant therapy approach for comprehensive management of epilepsy and associated depression employing pentylenetetrazole-kindled animals." | 3.83 | Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression. ( Goel, RK; Singh, T, 2016) |
| " This study investigates the effect of Arginine-Vasopressin (AVP) in pentylenetetrazol (PTZ)-induced seizures threshold and the probable role of nitric oxide (NO)." | 3.83 | The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice. ( Dehpour, AR; Doustimotlagh, AH; Javadi-Paydar, M; Javadian, N; Rahimi, N, 2016) |
| "The results indicate that pretreatment with the iridoid glycosides extracts of Feretia apodenthera improves generalized tonic-clonic seizures-induced by chemo-convulsants, protects mice against kindling development and oxidative stress, and improves brain GABA content in pentylenetetrazole-kindled mice." | 3.83 | Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures. ( Dabole, B; De Waard, M; Dzeufiet, PD; Menanga, JR; Taiwe, GS; Tchoya, TB, 2016) |
| " Additionally, noneffective doses of either KATP channel opener (cromakalim) or nonselective μ-opioid receptor agonist (morphine) in combination with a noneffective dose of zolpidem exerted a significant anticonvulsive effect on PTZ-induced seizures in mice." | 3.83 | Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice. ( Amiri, S; Dehdashtian, A; Dehpour, AR; Ghasemi, M; Ostadhadi, S; Sheikhi, M; Shirzadian, A, 2016) |
| " In the present study, the effect of tianeptine, an antidepressant, was evaluated against pentylenetetrazole (PTZ)-induced seizures, cognitive impairment and oxidative stress in rats." | 3.83 | Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats. ( Gupta, YK; Prabhakar, P; Reeta, Kh, 2016) |
| " This study aimed to investigate the effects of rebaudioside A (Reb-A), which is a steviol glycoside produced from the herb Stevia rebaudiana (Bertoni), on epileptic seizures and convulsions induced by pentylenetetrazole (PTZ)." | 3.83 | Rebaudioside A inhibits pentylenetetrazol-induced convulsions in rats. ( Balcıoglu, HA; Cavusoglu, T; Erbas, O; Erten, N; Gurgul, S; Ozlece, HK; Solmaz, V; Uyanikgil, Y, 2016) |
| "Hence, this study was conducted to evaluate the effects of an active fraction extracted from the leaves of Crinum jagus against seizures, depression-like behaviour and oxidative stress in pentylenetetrazole (PTZ)-induced kindling in mice." | 3.83 | Anticonvulsant activity of an active fraction extracted from Crinum jagus L. (Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models. ( Dabole, B; De Waard, M; Menanga, JR; Taiwe, GS; Tchoya, TB, 2016) |
| "The present experiments were performed in ten pigs where IT seizures were induced by controlled infusion of pentylenetetrazole." | 3.83 | Changes in vagus nerve activity associated with ictal tachycardia in pigs. ( Nielsen, TN; Sevcencu, C; Struijk, JJ, 2016) |
| " Although efficacious, AMPA-receptor antagonists, including perampanel (Fycompa), the only approved antagonist for epilepsy, induce dizziness and motor impairment." | 3.83 | Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. ( Bredt, DS; Burris, KD; Catlow, JT; Ding, C; Fitch, TE; Fitzjohn, SM; Gardinier, KM; Gernert, DL; Gleason, SD; Heinz, BA; Isaac, JT; Kato, AS; Lee, MR; Nisenbaum, ES; Ornstein, PL; Pasqui, F; Porter, WJ; Qian, Y; Rasmussen, K; Reel, J; Schober, DA; Sher, E; Tu, Y; Wafford, KA; Wang, H; Witkin, JM; Yu, H; Zwart, R, 2016) |
| " In this study, we aimed to investigate the anticonvulsant effect of acute administration of dextrometrophan on pentylenetetrazole (PTZ)-induced seizures and the probable involvement of the nitric oxide (NO) pathway and NMDA receptors in this effect." | 3.83 | Anticonvulsant effect of dextrometrophan on pentylenetetrazole-induced seizures in mice: Involvement of nitric oxide and N-methyl-d-aspartate receptors. ( Akbarian, R; Chamanara, M; Dehpour, AR; Mohseni, G; Norouzi-Javidan, A; Ostadhadi, S, 2016) |
| " We aim to reveal the anticonvulsant effects of dexketoprofen in pentylenetetrazol (PTZ)-induced seizures in rats." | 3.81 | Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures. ( Aksoy, D; Erbaş, O; Solmaz, V, 2015) |
| " Intraperitoneal pentylenetetrazole injection did not induce any seizure activity in the control rats, although it elicited seizures of variable severity in the polymicrogyria rats." | 3.81 | Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria. ( Matsui, K; Takano, T, 2015) |
| "Influence of ozone's treatments in mice submitted to PTZ-induced seizures was studied." | 3.81 | Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors. ( Cedeño, RI; Fernández, OS; Mallok, A; Pérez, AF; Soto, MT; Vaillant, JD; Viart, Mde L; Viebahn-Hänsler, R, 2015) |
| " This study compared the anticonvulsant properties of two NMDA receptor channel blockers, memantine and 1-phenylcyclohexylamine (IEM-1921), in a pentylenetetrazole (PTZ) model of seizures in rats and investigated their potencies in preventing PTZ-induced morphological changes in the brain." | 3.81 | N-methyl-D-aspartate receptor channel blockers prevent pentylenetetrazole-induced convulsions and morphological changes in rat brain neurons. ( Kim, KKh; Lavrentyeva, VV; Lukomskaya, NY; Magazanik, LG; Tumanova, NL; Vasilev, DS; Zaitsev, AV; Zhuravin, IA, 2015) |
| " In this study, we investigate the anti-convulsant and neuroprotective effects of thymoquinone (TQ) and vitamin C against pentylenetetrazole (PTZ)-induced generalized seizures." | 3.81 | Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus. ( Badshah, H; Kim, MO; Lee, HY; Naseer, MI; Ullah, I, 2015) |
| " We demonstrated that right common carotid ligation decreases the threshold for clonic seizures induced by pentylenetetrazole (PTZ), a GABA antagonist." | 3.81 | Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems. ( Abdolghaffari, AH; Aleyasin, AR; Azizi, Y; Chabouk, L; Dehpour, AR; Gooshe, M; Hassanzadeh, GR; Partoazar, A; Payandemehr, B; Tofigh, S, 2015) |
| "The present study evaluated the anticonvulsant effect of ginger in a model of clonic seizures induced with pentylenetetrazole (PTZ) in male mice." | 3.81 | Alteration of pentylenetetrazole-induced seizure threshold by chronic administration of ginger (Zingiber officinale) extract in male mice. ( Hosseini, A; Mirazi, N, 2015) |
| " This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)." | 3.81 | Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015) |
| "Montelukast showed anticonvulsant action and led to amelioration of oxidative stress markers in PTZ-induced seizures in rats." | 3.81 | Montelukast inhibits pentylenetetrazol-induced seizures in rats. ( Aksoy, D; Cevik, B; Erbas, O; Solmaz, V, 2015) |
| " Here, we expand on these findings to test whether ethosuximide can reduce the sensitivity to pentylenetetrazole-induced seizures during ethanol withdrawal." | 3.81 | Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal. ( Godwin, DW; Masicampo, ML; Riegle, MA; Shan, HQ; Xu, V, 2015) |
| "All the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole." | 3.81 | Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats. ( Ballesteros-Zebadúa, P; Franco-Pérez, J; Manjarrez-Marmolejo, J, 2015) |
| " In this study, we investigated the expression of JIP3 in temporal lobe epilepsy (TLE) and in a kainic acid (KA)-induced mouse model of epileptic seizures, and determined whether down-regulation of JIP3 can decrease susceptibility to seizures and neuron damage induced by KA." | 3.81 | Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures. ( Chen, X; Chen, Y; Cheng, L; Deng, W; Li, J; Li, Y; Lü, Y; Mi, X; Wang, N; Wang, X; Wang, Z; Xu, X; Zhang, Y, 2015) |
| " We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy." | 3.81 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015) |
| " In our study, we investigated the effects of rapamycin pretreatment on pentylenetetrazole (PTZ)-induced seizures in zebrafish." | 3.81 | Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish. ( Bonan, CD; da Costa Schaefer, I; Menezes, FP; Petersen, BD; Siebel, AM, 2015) |
| " All the newly synthesized compounds were investigated for the anticonvulsant activity against maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) models and their neurotoxicity were also evaluated by rotarod test." | 3.81 | Anticonvulsant and Neurotoxicity of Some Novel 1-([1,3,4]thiadiazino[6,5- b]indol-3-yl Semicarbazides. ( Deshmukh, R; Jha, AK; Kumar, SP; Thakur, AS, 2015) |
| " Seizures were then induced with pentylenetetrazole (PTZ)." | 3.81 | Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). ( Del Valle-Mojica, LM; Ortíz, JG; Torres-Hernández, BA, 2015) |
| " Thirty mice that developed seizures were randomly divided into three groups and administered PHT as well as the following treatments: saline (negative control); verapamil (20 mg/kg, positive control); and G." | 3.81 | Reversal of P-glycoprotein overexpression by Ginkgo biloba extract in the brains of pentylenetetrazole-kindled and phenytoin-treated mice. ( Chen, SL; Fan, Q; Ma, H; Zhang, C, 2015) |
| " In the present study, we examined its effect on convulsions, oxidative stress and cognitive impairment in pentylenetetrazole (PTZ) induced seizures in rats." | 3.81 | Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats. ( Gupta, YK; Joshi, R; Reeta, KH; Sharma, SK; Tripathi, M, 2015) |
| " Epileptic rats that developed spontaneous recurrent seizures after a pilocarpine-induced status epilepticus were treated with a KD or control diet (CD)." | 3.81 | Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. ( Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN, 2015) |
| "The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats." | 3.81 | Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. ( Choopankareh, S; Hosseini, M; Sadeghnia, HR; Salarinia, R; Shafei, MN; Vafaee, F; Zarepoor, L, 2015) |
| " Since previous works suggested a capacity for HupA to prophylax against seizures, we tested the HupA antiepileptic potential in pentylenetetrazole (PTZ) rat epilepsy model and explored its mechanism of action by spectral EEG analysis and by paired-pulse transcranial magnetic stimulation (ppTMS), a measure of GABA-mediated intracortical inhibition." | 3.81 | Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition. ( Dhamne, SC; Ekstein, D; Gersner, R; Rotenberg, A; Schachter, SC, 2015) |
| "The objective of this study was to evaluate the potential anticonvulsant effect of isopentyl ferulate, a new ester derived from ferulic acid in mice (Mus musculus) subjected to two models of induced seizures." | 3.81 | Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate. ( De Sousa, DP; Freitas, RM; Islam, MT; Junior, AL; Machado, KC; Oliveira, GL, 2015) |
| " Secondly, we determined seizure threshold for H1 and H3 receptors agonists and antagonists in mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.81 | Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice. ( Alijanpour, S; Amini-Khoei, H; Amiri, S; Dehpour, AR; Gooshe, M; Haj-Mirzaian, A; Hassanipour, M; Mehr, SE; Rahimi-Balaei, M; Shirzadian, A, 2015) |
| "To investigate the antiepileptic effects of Chaihushugan decoction (CHSGD) in rats with pentylenetetrazole (PTZ)-induced seizures and to discuss the impact of CHSGD on glutamate metabolism, a hypothesized underlying mechanism of seizure reduction." | 3.81 | Chaihushugan decoction exerts antiepileptic effects by increasing hippocampal glutamate metabolism in pentylenetetrazole-kindled rats. ( Wang, C; Xie, W; Yu, Y, 2015) |
| " We investigated whether neonatal morphine exposure affects pentylenetetrazol (PTZ)-induced seizures in adulthood." | 3.80 | The long-term effects of neonatal morphine administration on the pentylenetetrazol seizure model in rats: the role of hippocampal cholinergic receptors in adulthood. ( Gholami, M; Roshan-Milani, S; Saboory, E; Zare, S, 2014) |
| " In addition, the potency of compound 4n against seizures induced by Pentylenetetrazole, 3-Mercaptopropionic acid, and Bicuculline suggested its broad spectrum activity, and the mechanisms of action including inhibition of voltage-gated ion channels and modulation of GABAergic activity might involve in its anticonvulsant activity." | 3.80 | Design, synthesis and anticonvulsant activity evaluation of novel 4-(4-substitutedphenyl)-3-methyl-1H-1,2,4-triazol-5(4H)-ones. ( Cao, X; Liu, DC; Quan, ZS; Shu, B; Wang, SB; Zheng, Y, 2014) |
| " The present study evaluated the anticonvulsant effect of ginger in a model of clonic seizures induced with pentylenetetrazole (PTZ) in male mice." | 3.80 | Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice. ( Hosseini, A; Mirazi, N, 2014) |
| " Thus, we suggested that the dual FAAH and TRPV1 blockade with N-arachidonoyl-serotonin (AA-5-HT) would be efficacious in inhibiting pentylenetetrazole (PTZ)-induced seizures in mice." | 3.80 | Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels. ( de Oliveira, AC; Medeiros, DC; Moraes, MF; Moreira, FA; Vilela, LR, 2014) |
| "Novel N3 aryl/heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7-dimethoxyquinazolin-4(3H)- ones (8a-8l) were synthesized and evaluated for their anticonvulsant activity using various models of epilepsy, such as maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and intracerebroventricular AMPA (α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid)-induced seizures in mice." | 3.80 | Design, synthesis and pharmacological evaluation of N3 aryl/ heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7- dimethoxyquinazolin-4(3H)-ones as potential anticonvulsant agents. ( Banerjee, AG; Das, N; Shrivastava, SK, 2014) |
| "To explore the effect of edaravone (ED) on apoptosis of hippocampus neurons in seizures rats induced by pentylenetetrazole (PTZ)." | 3.80 | Effect of edaravone on apoptosis of hippocampus neuron in seizures rats kindled by pentylenetetrazole. ( Cheng, XL; Zhang, JJ, 2014) |
| "2 µL) were microinjected into the PPTN and after 5 min, the tail-withdrawal latency was measured again at 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, and 120 min after seizures evoked by intraperitoneal injection of pentylenetetrazole (64 mg/kg)." | 3.80 | Intrinsic connections within the pedunculopontine tegmental nucleus are critical to the elaboration of post-ictal antinociception. ( Almada, RC; Coimbra, NC; de Oliveira, RC; dos Anjos Garcia, T; Falconi-Sobrinho, LL; Mazzei-Silva, EC, 2014) |
| " We have previously reported the presence of SBH in a rodent model of low level hypothyroidism induced by maternal exposure to the goitrogen, propylthiouracil (PTU)." | 3.80 | Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. ( Gilbert, ME; Goodman, JH; McCloskey, DP; Ramos, RL, 2014) |
| "Single intramuscular injection of selective of NMDA receptor blocker memantine in the maximum dose of 20 mg/kg prevented the development of acute generalized tonic-clonic kainate seizures in 60% rats, but did not alleviate clonic kainate seizures and prevented chronic kainate lethality in only 30% rats." | 3.80 | Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats. ( Gmiro, VE; Serdyuk, SE; Veselkina, OS, 2014) |
| " The occurrence of the pentylenetetrazole (PTZ)-induced seizures in mice was significantly prevented by CLZ, even when exposed a lower dose of CLZ-SLN after administration by the oral route." | 3.80 | Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram. ( Allémann, E; Couraud, PO; Delie, F; González-Trujano, ME; Leyva-Gómez, G; López-Ruiz, E; Miller, F; Quintanar-Guerrero, D; Romero, I; Wekslerg, B, 2014) |
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 3.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| " We report that, among a spectrum of in vivo activities, both 15b and 15c displayed significant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.80 | Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides. ( Filipek, B; Höfner, GC; Kowalczyk, P; Kulig, K; Mucha, M; Podkowa, A; Rapacz, A; Sałat, K; Wanner, KT, 2014) |
| " Susceptibility to pentylenetetrazole-induced seizures was assessed by electrocorticography in head-restrained nonanesthetized rats." | 3.80 | Normotopic cortex is the major contributor to epilepsy in experimental double cortex. ( Buhler, E; Chauvin, Y; Jalabert, M; Malvache, A; Manent, JB; Peret, A; Petit, LF; Represa, A; Watrin, F, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 3.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "Besides the clinical applications of penicillamine, some reports show that use of D-penicillamine (D-pen) has been associated with adverse effects such as seizures." | 3.80 | Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways. ( Dehpour, AR; Heidary, MR; Javadi-Paydar, M; Jazaeri, F; Rahimi, N; Sadeghzadeh, M, 2014) |
| "We have previously reported that an episode of pentylenetetrazole (PTZ)-induced status epilepticus (SE) in immature rats induces a long-term increase in cholinergic excitation assessed in the adult brain in vitro." | 3.80 | A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way. ( Kouis, P; Mikroulis, A; Psarropoulou, C, 2014) |
| "It was the aim of this study to determine the potential effect of walnut kernel extract (WKE) on experimentally induced seizures in rats and to evaluate the role of benzodiazepines and ethosuximide (ESM) within these pathways." | 3.80 | Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure. ( Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T, 2014) |
| ") and some flavonoids in the pentylenetetrazole-induced seizures in mice." | 3.80 | Anticonvulsant and antioxidant effects of Tilia americana var. mexicana and flavonoids constituents in the pentylenetetrazole-induced seizures. ( Aguirre-Hernández, E; Cárdenas-Rodríguez, N; Carmona-Aparicio, L; Coballase-Urrutia, E; González-Trujano, ME; Ruíz-García, M; Sampieri, A, 2014) |
| "Adenosine has anticonvulsant effects in various models of seizures." | 3.80 | The role of alpha-2 adrenoceptors in the anticonvulsant effects of adenosine on pentylenetetrazole-induced seizure threshold in mice. ( Mansoori, E; Moezi, L; Niknahad, H; Shafaroodi, H, 2014) |
| "We recently discovered that the antidepressant sertraline is an effective inhibitor of hippocampus presynaptic Na+ channel permeability in vitro and of tonic-clonic seizures in animals in vivo." | 3.80 | Sertraline reduces IL-1β and TNF-α mRNA expression and overcomes their rise induced by seizures in the rat hippocampus. ( Aldana, BI; Gómez, CD; Sitges, M, 2014) |
| " To do this, we used the pentylenetetrazole (PTZ) model of clonic seizures, open-field test, hole-board test, forced swimming test, and plasma corticosterone assay." | 3.80 | Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice. ( Amiri, S; Dehpour, AR; Haj-Mirzaian, A; Imran-Khan, M; Kordjazy, N; Mehr, SE; Rahimi Balaei, M; Shirzadian, A, 2014) |
| "In the current study the link among the γ-hydroxybutyrate (GHB)/pentylenetetrazole (PTZ)-induced absence-like seizures and concomitant decreases in the core temperature, as well as electroencephalographic (EEG) activity during rewarming from deep hypothermia produced by a drug-free protocol were investigated." | 3.79 | GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy. ( Andjus, PR; Ilić, TV; Ostojić, ZS; Vesković, SM, 2013) |
| " This study was envisaged to evaluate the ameliorative effect of Curcumin on depression like behavior and cognitive impairment observed in pentylenetetrazole kindled animals." | 3.79 | Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice. ( Choudhary, KM; Goel, RK; Mishra, A; Poroikov, VV, 2013) |
| "Although caffeine supplementation has a beneficial effect on people with neurological disorders, its implications for oxidative damage related to seizures are not well documented." | 3.79 | Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rats. ( Castro, M; Fighera, MR; Gerbatin, RR; Mota, BC; Rodrigues, FS; Royes, LF; Souza, MA, 2013) |
| "Alterations in the NO pathway play an important role in the development of convulsive seizures via the glutamatergic and GABAergic systems in acute pentylenetetrazole (PTZ) seizure animals." | 3.79 | The threshold of pentylenetetrazole-induced convulsive seizures, but not that of nonconvulsive seizures, is controlled by the nitric oxide levels in murine brains. ( Danjo, S; Itoh, K; Miyai, A; Nakamura, Y; Watanabe, M, 2013) |
| "In the present study the contribution of estradiol in sex-dependent differences of pentylenetetrazole (PTZ)-induced seizures was investigated in rats." | 3.79 | Contribution of estradiol in sex-dependent differences of pentylenetetrazole-induced seizures in rats. ( Hosseini, M; Sadeghnia, HR; Salehabadi, S; Soukhtanloo, M, 2013) |
| "Pentylenetetrazole (PTZ) is a widely-used convulsant used in studies of epilepsy; its subcutaneous injection generates an animal model with stable seizures." | 3.79 | BDNF-TrkB signaling pathway is involved in pentylenetetrazole-evoked progression of epileptiform activity in hippocampal neurons in anesthetized rats. ( Ding, J; Fan, W; Jin, LY; Liu, J; Liu, X; Liu, XL; Peng, LC; Wang, X; Wang, Y, 2013) |
| " We aimed to evaluate the anticonvulsant effect of the essential oil and methanolic extract of the plant on chemical and electrically seizures." | 3.79 | Anticonvulsant effect of the essential oil and methanolic extracts of Zataria multiflora Boiss. ( Abdar, M; Mandegary, A; Sharififar, F, 2013) |
| "Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures." | 3.79 | The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice. ( Akbarian, R; Moezi, L; Niknahad, H; Shafaroodi, H, 2013) |
| " Initial anticonvulsant screening was performed in mice (ip) using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizures tests." | 3.79 | Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones. ( Chlebek, I; Kamiński, K; Obniska, J; Rzepka, S; Wiklik, B, 2013) |
| ") administration of α-MSH altered PTZ- and pilocarpine-induced seizures." | 3.79 | Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures. ( Guerra, GP; Jesse, AC; Lenz, QF; Marafiga, JR; Mello, CF; Oliveira, SM; Santos, AC; Scimonelli, TN; Temp, FR, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 3.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| " This new method documented that seizures in the zebrafish EAST model were ameliorated by pentobarbitone, but not diazepam, validating its usefulness." | 3.79 | Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings. ( Bockenhauer, D; Kleta, R; Mahmood, F; Russell, C; Stanescu, HC; Zdebik, AA, 2013) |
| "In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar-turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ)." | 3.79 | Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. ( Afrikanova, T; Aibuldinov, YK; de Witte, PA; Dehaen, W; Esguerra, CV; Orellana-Paucar, AM; Thomas, J, 2013) |
| " The analgesic and anticonvulsant effects of piperine were studied in mice using acetic acid-induced writhing, tail flick assay, pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures models." | 3.79 | The analgesic and anticonvulsant effects of piperine in mice. ( Alhumayyd, MS; Bukhari, IA; Gilani, AH; Mahesar, AL; Pivac, N, 2013) |
| " Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice." | 3.79 | Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice. ( Agarwal, NB; Agarwal, NK; Jain, S; Mediratta, PK; Nagpal, D; Sharma, KK, 2013) |
| ") was used to evaluate the potential effect on pentylenetetrazole induced seizures in mice." | 3.79 | Selenium induced anticonvulsant effect: a potential role of prostaglandin E(1) receptor activation linked mechanism. ( Rehni, AK; Singh, TG, 2013) |
| " And the potency of compound 14 against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide and 3-Mercaptopropionic acid in the chemical-induced seizure tests suggested that compound 14 displayed wide spectrum of activity in several models." | 3.79 | Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives. ( Bian, M; Deng, XQ; Gong, GH; Quan, ZS; Wei, CX, 2013) |
| "We aimed to reveal the anti-convulsant effects of oxytocin (OT) in pentylenetetrazol (PTZ)-induced seizures in rats." | 3.79 | Oxytocin inhibits pentylentetrazol-induced seizures in the rat. ( Bora, S; Erbas, O; Evren, V; Korkmaz, HA; Peker, G; Yılmaz, M, 2013) |
| " Our data have demonstrated that pentylenetetrazole (PTZ)-induced seizures did not alter ATP, ADP, and AMP hydrolysis in brain membrane fractions." | 3.79 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| "To study the effects of noninvasive transcranial focal electrical stimulation (TFS) via tripolar concentric ring electrodes (TCRE) on the electrographic and behavioral activity from pentylenetetrazole (PTZ)-induced seizures in rats." | 3.79 | Effects of transcranial focal electrical stimulation via tripolar concentric ring electrodes on pentylenetetrazole-induced seizures in rats. ( Besio, WG; Gale, K; Makeyev, O; Medvedev, A, 2013) |
| "The neuropharmacological effects of the extract were evaluated using a variety of models, such as the elevated plus maze (EPM), the forced swimming test (FST), the pentobarbital potentiation test (PTBt), pentylenetetrazole-induced seizures test (PTZt), and the open field test (OFT)." | 3.79 | Neuropharmacological in vivo effects and phytochemical profile of the extract from the aerial parts of Heteropterys brachiata (L.) DC. (Malpighiaceae). ( Aguilar-Rojas, A; González-Cortazar, M; Herrera-Ruiz, M; Huerta-Reyes, M; León, E; Reyes-Chilpa, R; Tortoriello, J; Zamilpa, A, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 3.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "To investigate the anticonvulsant activity of the lobeline isolated from the Lobelia nicotianaefolia in chemoconvulsant-induced seizures and its biochemical mechanism by investigating relationship between seizure activities and altered gamma amino butyric acid (GABA) in brain of mice in Pentylenetetrazol (PTZ) seizure models." | 3.78 | Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice. ( Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM, 2012) |
| "Peripheral subchronic (24 h) pre-treatment with naloxonazine antagonised the antinociception elicited by tonic-clonic seizures." | 3.78 | Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits μ1-opioid receptor to modulate post-ictal antinociception. ( Coimbra, NC; de Freitas, RL; Felippotti, TT, 2012) |
| " In vitro, sodium selenate reduced tau phosphorylation in human neuroblastoma cells and reversed the increase in tau phosphorylation induced by the PP2A inhibitor, okadaic acid." | 3.78 | Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models. ( Chen, T; Corcoran, NM; Grundy, R; Hovens, CM; Jones, NC; Nguyen, T; O'Brien, TJ; Velakoulis, D, 2012) |
| "The possible involvement of oxytocin (OT) in the generation of seizures has not received a lot of attention in the past, although generalized epileptic convulsions were observed in humans following intravenous OT infusion." | 3.78 | Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors. ( Loyens, E; Michotte, Y; Schallier, A; Smolders, I; Vermoesen, K, 2012) |
| " In this study, we tested the hypothesis that a new KYNA analog administered systemically in a sufficient dose results in a decreased population spike activity recorded from the pyramidal layer of area CA1 of the hippocampus, and also provides protection against pentylenetetrazole-induced epileptiform seizures." | 3.78 | A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study : special issue related to kynurenine. ( Demeter, I; Fülöp, F; Gellért, L; Nagy, K; Toldi, J; Vécsei, L, 2012) |
| " calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole-induced seizures model in rats." | 3.78 | Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine. ( Gupta, YK; Katyal, J; Sarangal, V, 2012) |
| "In pentylenetetrazole-induced seizure, the ethanol extract at doses of 250 and 1000mg/kg prolonged the onset of seizures." | 3.78 | UPLC-TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities. ( Aslan, M; Deliorman Orhan, D; Orhan, IE; Orhan, N; Süküroğlu, M, 2012) |
| "Taken together, sub-chronic pioglitazone treatment exerts anti-convulsant effects in intravenous and intraperitoneal pentylenetetrazole-induced seizures of mice probably through induction of constitutive nitric oxide synthase." | 3.78 | Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide. ( Dehpour, AR; Ghorbani, H; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H; Zaeri, M, 2012) |
| " Thus, the present study investigated the influence of anandamide on pentylenetetrazole-induced seizures in mice pretreated with TRPV1 or CB(1) receptor antagonists." | 3.78 | Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures. ( Manna, SS; Umathe, SN, 2012) |
| " Administration of both the extract and diazepam (2 mg/kg) reduced spontaneous locomotory activity, potentiated hexobarbital (60 mg/kg)-induced sleeping parameters and prevented pentylenetetrazole (80 mg/kg)-induced seizures relative to the controls." | 3.78 | Effects of Hypericum montbretti extract on the central nervous system and involvement of GABA (A)/Benzodiazepine receptors in its pharmacological activity. ( Can, OD; Ozkay, UD, 2012) |
| "The present study demonstrates the anticonvulsant effect of acute pioglitazone on PTZ-induced seizures in mice." | 3.78 | Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice. ( Adabi Mohazab, R; Dehpour, AR; Delfan, B; Javadi-Paydar, M, 2012) |
| " mascula (HEOM) tuber was evaluated against seizures, seizure-induced oxidative stress and cognitive deficit in pentylenetetrazole and maximal electroshock-induced seizures in rats." | 3.78 | Anticonvulsant and antioxidative activity of hydroalcoholic extract of tuber of Orchis mascula in pentylenetetrazole and maximal electroshock induced seizures in rats. ( Kumar Gupta, Y; Mehla, J; Pahuja, M, 2012) |
| "Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy." | 3.78 | The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012) |
| " Initial anticonvulsant screening was performed in mice after intraperitoneal administration in the maximal electroshock seizure test (MES) and subcutaneous pentylenetetrazole seizures test (scPTZ)." | 3.78 | Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II. ( Kamiński, K; Obniska, J; Rzepka, S, 2012) |
| " The in vivo screening data suggest that all the analogs have the ability to protect against pentylenetetrazole-induced seizures." | 3.78 | Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore. ( Amini, M; Davood, A; Iman, M; Nematollahi, A; Shafaroodi, H; Shirazi, M, 2012) |
| " The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA-a highly selective cannabinoid CB1 receptor agonist) on the protective action of clonazepam, ethosuximide, phenobarbital, and valproate against pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.78 | Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, M; Barcicka-Klosowska, B; Florek-Luszczki, M; Haratym-Maj, A; Luszczki, JJ; Zolkowska, D, 2012) |
| " Additionally, the anticonvulsant profile of CBDV (50-200 mg·kg(-1) ) in vivo was investigated in four rodent seizure models: maximal electroshock (mES) and audiogenic seizures in mice, and pentylenetetrazole (PTZ) and pilocarpine-induced seizures in rats." | 3.78 | Cannabidivarin is anticonvulsant in mouse and rat. ( Duncan, M; Futamura, T; Glyn, SE; Hill, AJ; Hill, TD; Jones, NA; Mercier, MS; Stephens, GJ; Stott, CG; Whalley, BJ; Williams, CM; Yamasaki, Y, 2012) |
| "), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine." | 3.78 | The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. ( Aldana, BI; Gómez, CD; Nekrassov, V; Sitges, M, 2012) |
| " We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target." | 3.78 | Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures. ( Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C, 2012) |
| "To study the different effects of soy extract on pentylenetetrazole (PTZ)-induced seizures in the presence and absence of ovarian hormones in rats, and the gender-dependent differences in the effects of phytoestrogens on behavior." | 3.78 | Estrogen-dependent effect of soy extract on pentylenetetrazole-induced seizures in rats. ( Ebrahimzadeh Bideskan, AR; Enayatfard, L; Hosseini, M; Karami, R; Mohammadpour, T; Sadeghnia, HR, 2012) |
| "To investigate the possible anticonvulsant effect of different extracts of Eugenia caryophyllata (clove) on pentylenetetrazole (PTZ)-induced seizures in mice." | 3.78 | Effects of different extracts of Eugenia caryophyllata on pentylenetetrazole-induced seizures in mice. ( Ghorbani, A; Hosseini, M; Jafarianheris, T; Parvaneh, M; Rakhshandeh, H; Sadeghnia, HR; Seddighi, N, 2012) |
| " Previously, we applied noninvasive transcranial focal stimulation via tripolar concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole." | 3.78 | Sensor integration of multiple tripolar concentric ring electrodes improves pentylenetetrazole-induced seizure onset detection in rats. ( Besio, WG; Ding, Q; Kay, SM; Makeyev, O, 2012) |
| " It showed a significant inhibition of the seizures induced by electroshock and pentylenetetrazole in a dose dependent manner and the activity was comparable to phenytoin and diazepam." | 3.77 | Anticonvulsant activity of embelin isolated from Embelia ribes. ( Badami, S; Mahendran, S; Thippeswamy, BS; Veerapur, VP, 2011) |
| "These results show that the anesthetics propofol and 2,6-di-sec-butylphenol may be substituted in the para position with a 1-hydroxy-2,2,2-trifluoroethyl moiety and the resulting molecules have anticonvulsant activity in the 6 Hz model while exhibiting less toxicity (ataxia) than the parent 2,6-dialkylphenols." | 3.77 | The anticonvulsant effects of propofol and a propofol analog, 2,6-diisopropyl-4-(1-hydroxy-2,2,2-trifluoroethyl)phenol, in a 6 Hz partial seizure model. ( Baker, MT, 2011) |
| " Three tests were used: pentylenetetrazole (PTZ)-induced seizures, isolation-induced ultrasonic vocalizations, and motor performance." | 3.77 | Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats. ( Kubová, H; Mareš, P; Mikulecká, A, 2011) |
| " Despite this increase, chronic rofecoxib treatment did not attenuate the severity of acute PTZ-induced seizures and failed to alter kindling development or maintenance." | 3.77 | Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition. ( Claycomb, RJ; Hewett, JA; Hewett, SJ, 2011) |
| "The anticonvulsant activity of BmK AS, a sodium channel site 4-selective modulator purified from scorpion venom (Buthus martensi Karsch), was investigated in unanesthetized rats with acute pentylenetetrazole (PTZ)- and pilocarpine-induced seizures." | 3.77 | Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator. ( Chen, L; Feng, Q; Ji, YH; Wang, Y; Weng, CC; Zhang, XY; Zhao, R; Zhu, HY, 2011) |
| " Inhibition of the GAT1 by the clinically available anti-epileptic drug tiagabine has been an effective strategy for the treatment of some patients with partial seizures." | 3.77 | Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. ( Clausen, RP; Danbolt, NC; Guo, C; Holen, T; Holmseth, S; Hua, R; Laake, P; Lehre, AC; Madsen, KK; Olofsson, AM; Poblete-Naredo, I; Rowley, NM; Rusakov, DA; Schousboe, A; White, HS; Zhou, Y, 2011) |
| " In addition, the potence of compound 1i against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide, 3-Mercaptopropionic acid, and Bicuculline in the chemical-induced seizure tests suggested that compound 1i displayed broad spectrum activity in several models, and it is likely to have several mechanisms of action including inhibiting voltage-gated ion channels and modulating GABAergic activity." | 3.77 | Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. ( Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX, 2011) |
| "Magnesium sulfate (MgSO₄) has been used to prevent seizures in eclampsia." | 3.77 | The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats. ( Futuro Neto, Hde A; Nakamura-Palacios, EM; Oliveira, LD; Oliveira, RW, 2011) |
| " Similar to lithium, agmatine also plays a protective role in the CNS against seizures and has been reported to enhance the effect of different antiepileptic agents." | 3.77 | Additive anticonvulsant effects of agmatine and lithium chloride on pentylenetetrazole-induced clonic seizure in mice: involvement of α₂-adrenoceptor. ( Amouzegar, A; Bahremand, A; Dehpour, AR; Ebrahimi, A; Ghasemi, A; Ghasemi, M; Khezrian, M; Meibodi, MA; Montaser-Kouhsari, L; Payandemehr, B; Rahimian, R; Ziai, P, 2011) |
| " This study investigated the effect of the interaction of melatonin and agmatine on seizure susceptibility in the mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.77 | The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H, 2011) |
| " In the current study we investigated whether atorvastatin or simvastatin alters the seizures induced by pentylenetetrazol (PTZ), a classical convulsant." | 3.77 | Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol-induced seizures. ( de Mello, CF; de Oliveira, CV; Ferreira, J; Funck, VR; Furian, AF; Guerra, GP; Mallmann, CA; Oliveira, MS; Pereira, LM; Rambo, LM; Ribeiro, LR; Royes, LF, 2011) |
| " In this study, we tested the effect of pentylenetetrazole (PTZ)-induced seizures on ectonucleotidase and ADA activities in adult zebrafish brain." | 3.77 | PTZ-induced seizures inhibit adenosine deamination in adult zebrafish brain membranes. ( Bogo, MR; Bonan, CD; Capiotti, KM; Piato, AL; Seibt, KJ; Siebel, AM, 2011) |
| " The present study was designed to determine the anticonvulsant and/or proconvulsant effects of three antidepressants (citalopram, reboxetine, bupropion) against pilocarpine- and pentylenetetrazole-induced acute seizures in larval zebrafish and mice." | 3.77 | Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models. ( Afrikanova, T; Clinckers, R; Crawford, AD; de Witte, PA; Esguerra, CV; Loyens, E; Massie, A; Michotte, Y; Schallier, A; Serruys, AS; Smolders, I; Vermoesen, K, 2011) |
| "The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures." | 3.77 | Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. ( Citó, AM; de Almeida, AA; de Freitas, RM; Júnior, JS; Saffi, J; Tomé, Ada R, 2011) |
| " In this study we applied noninvasive transcranial focal stimulation (TFS) via concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole (PTZ) to assess the effect of TFS on the electrographic activity." | 3.77 | Transcranial focal stimulation via concentric ring electrodes reduced power of pentylenetetrazole-induced seizure activity in rat electroencephalogram. ( Besio, WG; Kay, SM; Koka, K; Liu, X; Makeyev, O, 2011) |
| "The present study was performed to investigate whether or not carvedilol (a beta-adrenoreceptor antagonist) potentiates the anticonvulsive activity of gabapentin against ICES (Increasing current electroshock) and PTZ (Pentylenetetrazole) induced seizures in mice." | 3.77 | Influence of carvedilol on anticonvulsant effect of gabapentin. ( Goel, A; Goel, R; Kumar, Y, 2011) |
| "The physiologic response of wild-types and mice lacking both CK-B and UbCKmit (CK--/--mice) to pentylenetetrazole (PTZ)-induced seizures was measured using electroencephalography (EEG) recordings and behavioral monitoring." | 3.76 | Complete brain-type creatine kinase deficiency in mice blocks seizure activity and affects intracellular calcium kinetics. ( Oerlemans, F; Scheenen, WJ; Streijger, F; Van der Zee, CE; van Luijtelaar, G; Wieringa, B, 2010) |
| " CBD (1, 10, and 100 mg/kg) effects were also examined in vivo using the pentylenetetrazole model of generalized seizures." | 3.76 | Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. ( Bevan, SA; Hill, AJ; Jones, NA; Smith, I; Stephens, GJ; Whalley, BJ; Williams, CM, 2010) |
| " The extract was submitted to a screening in anticonvulsant assays including NMDA-, kainic acid (KA)-, pentylenetetrazol (PTZ)- and bicuculline (BIC)-induced seizures in rats." | 3.76 | Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats. ( Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG, 2010) |
| "In various animals methionine sulfoximine (MSO) induces tonic-clonic seizures resembling the most striking form of human epilepsies." | 3.76 | Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures. ( Cloix, JF; Hévor, T; Martin, B; Tahi, Z, 2010) |
| "The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test." | 3.76 | Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 3.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures." | 3.76 | Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice. ( Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| " Seizures were induced by the 6 Hz test, kainic acid, maximal electroshock, or pentylenetetrazol." | 3.76 | Seizure tests distinguish intermittent fasting from the ketogenic diet. ( Bergbower, E; Hardwick, JM; Hartman, AL; Kennedy, M; Zheng, X, 2010) |
| " The anticonvulsant activity of all of the synthesized compounds was evaluated against maximal electrical shock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizures." | 3.76 | Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives. ( Abd El-Latif, HA; Abu Yossef, HA; Hassan, GS; Ragab, FA; Yahya, TA, 2010) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 3.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| " Here, tonic-clonic seizures were induced with a convulsive dose of pentylenetetrazole (PTZ), and acute seizure recurrence was evoked with a subconvulsive dose of the drug." | 3.76 | Stress within the postseizure time window inhibits seizure recurrence. ( Cao, J; Duan, TT; Mao, RR; Tan, JW; Tian, M; Xu, L; Zhou, QX, 2010) |
| "Effects of the inhibitor of the expression of Heat shock proteins 70 kDa (Hsp70), quercetin on seizures and movement disorders induced by N-methyl D-aspartate (NMDA) or pentylenetetrazole in adult rats Wistar were investigated using behavioral methods." | 3.76 | [EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures]. ( Ekimova, IV; Feĭzulaev, BA; Guzhova, IV; Nitsinskaia, LE; Pastukhov, IuF, 2010) |
| "For the acute study, in the maximal electroshock seizure model, the administration of 1 mg/kg of amlodipine resulted in the complete abolition of seizures in 33 percent of the mice, and this was increased to 67 percent with the administration of 4 mg/kg." | 3.76 | An experimental study of the anticonvulsant effect of amlodipine in mice. ( Sathyanarayana Rao, KN; Subbalakshmi, NK, 2010) |
| "Pioglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, is used in inflammatory brain diseases, and it was shown to protect against seizures in genetically epileptic mice." | 3.76 | Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice. ( Abdallah, DM, 2010) |
| " In the present study, using a model of clonic seizures induced with pentylenetetrazole (PTZ) in male Swiss mice, we investigated whether there is any interaction between lithium and either calcium channel blockers (CCBs: nifedipine, verapamil, and diltiazem) or N-methyl-D-aspartate (NMDA) receptor antagonists (ketamine and MK-801) in modulating seizure threshold." | 3.76 | Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Heydarpour, P; Meskar, H; Nazarbeiki, S; Shafaroodi, H; Talab, SS; Ziai, P, 2010) |
| " The effects of the protein synthesis inhibitor cycloheximide (CHX) were examined on the expression and reconsolidation of pentylenetetrazole (PTZ) - induced kindled seizures and for comparative purposes, on the reconsolidation of conditioned fear response (conditioned freezing)." | 3.76 | The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures. ( Bidziński, A; Lehner, M; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D, 2010) |
| "2 s, while chemical seizures were induced by intraperitoneal injection of pentylenetetrazole at its CD97 dose (97% convulsive dose for the clonic phase)." | 3.76 | Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice. ( Anitha, T; Gajera, K; Jayaraman, R; Joshi, VD; Ladani, K; Manisenthil, KT; Palei, NN, 2010) |
| " Initial anticonvulsant screening was performed using intraperitoneal (ip) maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizures tests." | 3.76 | Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins. ( Byrtus, H; Kamiński, K; Karolak-Wojciechowska, J; Obniska, J; Pawłowski, M; Szczesio, M, 2010) |
| " In acute study, seizures were induced by either pentylenetetrazole (PTZ) injection or maximal electroshock seizures, while in the chronic study, kindling was induced by injecting PTZ (30 mg/kg, s." | 3.76 | Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats. ( Arora, T; Banerjee, BD; Joshi, V; Mahajan, P; Mediratta, PK; Mehta, AK; Mehta, KD; Rathor, N; Sharma, AK; Sharma, KK, 2010) |
| " officinalis (HAEEO) administered intraperitoneally to rats was evaluated on pentylenetetrazole (PTZ) induced seizures, cognitive deficit and oxidative stress markers viz malondialdehyde (MDA) and glutathione." | 3.76 | Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats. ( Arya, DS; Bhatia, J; Golechha, M, 2010) |
| " Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats." | 3.76 | Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. ( Gupta, P; Gupta, YK; Mehla, J; Reeta, KH, 2010) |
| "In the present study, the effects of tramadol on pentylenetetrazole (PTZ)-induced seizures and involvement of nitric oxide (NO) were assessed in mice." | 3.76 | Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice. ( Asghari-Roodsari, A; Dehpour, AR; Javadi-Paydar, M; Khodadad, TK; Lesani, A; Norouzi, A; Shirkhodaei, M, 2010) |
| "This study investigated the in vitro antioxidant activity of (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD), the anticonvulsant effect of BPD on seizures induced by pilocarpine (PC), pentylenetetrazole (PTZ) and 4-aminopyridine (4-AMP) and the mechanism involved." | 3.76 | Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Roman, SS; Wilhelm, EA, 2010) |
| "Although morphine has an anticonvulsant effect in several animal models of seizures, its potential clinical application in epilepsy may be hindered by its adverse effects like opioid tolerance." | 3.76 | Administration of lithium and magnesium chloride inhibited tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Moezi, L; Montaser-Kouhsari, L; Saberi, M; Shafaroodi, H; Ziai, P, 2010) |
| " Also, it was found to be protective against picrotoxin- and kainic acid-induced seizures." | 3.75 | Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog. ( Jain, R; Kaur, N; Krishnamoorthy, S; Meena, CL; Monga, V; Pawar, C; Rajput, SK; Sharma, SS, 2009) |
| "The time response of changes in the brain concentration of kynurenic acid (KYNA) was examined in rats subjected to the pentylenetetrazol (PTZ)-induced kindling of seizures (n=32)." | 3.75 | Time course of changes in the concentration of kynurenic acid in the brain of pentylenetetrazol-kindled rats. ( Bidziński, A; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Sobolewska, A; Szyndler, J; Taracha, E; Turzyńska, D, 2009) |
| "Our findings suggest that the induction of acute seizures with PTZ, but not with MES, in animals pretreated with pilocarpine (regardless of SE induction) might constitute an effective and valuable method to screen AEDs and to study mechanisms involved in pharmacoresistant temporal lobe epilepsy (TLE)." | 3.75 | Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models. ( Albuquerque, C; Blanco, MM; Cavarsan, CF; dos Santos, JG; Hummel, M; Kohek, SR; Mello, LE; Perez-Mendes, P, 2009) |
| "Intraperitoneal injection of paxilline was sufficient to eliminate tonic-clonic seizures in picrotoxin-treated animals." | 3.75 | Anticonvulsant effects of the BK-channel antagonist paxilline. ( Barth, AL; Benedetti, BL; Sheehan, JJ, 2009) |
| "The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance." | 3.75 | Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone. ( Dehpour, AR; Ghahremani, MH; Ghasemi, M; Rafiei-Tabatabaei, N; Riazi, K; Roshanpour, M, 2009) |
| " platyphylla stem bark were studied on pentylenetetrazole-, strychnine- and maximal electroshock seizures in mice." | 3.75 | Anticonvulsant properties of saponins from Ficus platyphylla stem bark. ( Adamu, SS; Amos, S; Anuka, JA; Chindo, BA; Connelly, WK; Gamaniel, KS; Lees, G; McNeil, L; Yaro, AH, 2009) |
| "To characterize the interactions between levetiracetam and the antiepileptic drugs gabapentin, tiagabine, and vigabatrin in suppressing pentylenetetrazole-induced clonic seizures in mice, type II isobolographic analysis was used." | 3.75 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| " The anticonvulsant activity of all the title compounds was investigated against maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scMET) models and their neurotoxicity was also evaluated." | 3.75 | Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene. ( Adhikari, AV; Kulandasamy, R; Stables, JP, 2009) |
| " In the pentylenetetrazole-induced seizures test the C." | 3.75 | Sedative and anticonvulsant effects of an alcoholic extract of Capparis decidua. ( Goyal, M; Nagori, BP; Sasmal, D, 2009) |
| "This study investigated the anticonvulsant effect of 3-alkynyl selenophene (3-ASP) on pilocarpine (PC)-, pentylenetetrazole (PTZ)- and kainic acid (KA)-induced seizures and mortality in 21-day-old rats." | 3.75 | Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA, 2009) |
| " The anticonvulsant actions of the extracted compounds were studied in pentylenetetrazole-induced clonic seizures in mice and their effect on motor coordination was studied using the rota-rod test in rats." | 3.75 | The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) N.E. Brown chemotypes. ( Beleboni, RO; França, SC; Marques, MO; Neto, AC; Netto, JC; Pereira, AM; Pereira, PS; Taleb-Contini, SH, 2009) |
| "In order to assess the role of nitric oxide/cyclicGMP signaling pathway in the anticonvulsant effect of benzodiazepines, we studied the potential interaction of a phosphodiesterase type 5 inhibitor, sildenafil with the effect of diazepam on a mouse model of clonic seizures induced by intravenous infusion of GABA antagonist, pentylenetetrazole (PTZ)." | 3.75 | The interaction of sildenafil with the anticonvulsant effect of diazepam. ( Dehpour, AR; Gholipour, T; Jabbarzadeh, A; Nezami, BG; Rasouli, A; Riazi, K; Sharifzadeh, M, 2009) |
| "This study was designed so as to characterize the interactions between levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of type II isobolographic analysis." | 3.75 | Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2009) |
| " injection to mice at doses of 30, 100, and 300 mg/kg body weight synthesized compounds were examined in the maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice." | 3.75 | Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea. ( Jain, NK; Kashaw, SK; Kashaw, V; Mishra, P; Stables, JP, 2009) |
| "TNBS-induced colitis increased seizure susceptibility to a subconvulsive dose of pentylenetetrazole; the immunomodulator thalidomide was protective." | 3.75 | Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model. ( Avti, PK; Chakrabarti, A; Khanduja, KL; Medhi, B; Prakash, A, 2009) |
| ") pretreatment significantly delayed onset and reduced the frequency of convulsions in pentylenetetrazole-induced seizures." | 3.75 | Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters. ( Ingole, S; Jain, G; Jain, R; Kaur, N; Meena, CL; Monga, V; Rajput, SK; Sharma, SS; Singh, JN, 2009) |
| " A number of VPA analogues and their amide, N-methylamide and urea derivatives, were synthesized and evaluated in animal models of neuropathic pain and epilepsy." | 3.75 | Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. ( Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B, 2009) |
| " In this study, we investigated the basic mechanism of aminophylline [theophylline-2-ethylenediamine]-induced convulsions and the effects of Brewer's yeast-induced pyrexia in mice." | 3.75 | Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice. ( Araki, H; Kawasaki, H; Ochi, R; Suemaru, K, 2009) |
| " 3,5-DBr-L-Phe was also given as a single bolus prior to pentylenetetrazole (PTZ) injection to induce seizures or prior to the administration of the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) to cause disruption of prepulse inhibition (PPI) of startle (sensorimotor gating deficit)." | 3.75 | Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. ( Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C, 2009) |
| "The aim of this study was to determine the correlations among hippocampal damage, spontaneous recurrent seizures (SRS), and mossy fiber sprouting (MFS) using pentylenetetrazole (PTZ) kindling model." | 3.75 | Mossy fiber sprouting, hippocampal damage and spontaneous recurrent seizures in pentylenetetrazole kindling rat model. ( Cai, XF; Chen, JM; Chen, Y; Dang, J; Fang, J; Fu, JJ; Guo, TH; Huang, WJ; Li, FR; Ma, YF; Tian, FF; Wang, XH; Zeng, C, 2009) |
| " This study examined the anticonvulsant activity of its aqueous stem bark extract (100 - 400mg/kg) against maximal electroshock and pentylenetetrazole-induced seizures in rodents." | 3.75 | Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents. ( Ching, FP; Omogbai, EK; Otokiti, IO, 2009) |
| " Therefore, we determined the effects of two Rho-kinase inhibitors, Y-27632 and fasudil, on seizures induced by pentylenetetrazole (PTZ) or maximal electroconvulsive shock (MES)." | 3.74 | Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. ( Büyükafşar, K; Inan, S, 2008) |
| "The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis." | 3.74 | Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. ( Luszczki, JJ, 2008) |
| "The present study was designed to investigate the importance of sex differences in the interaction between dizocilpine (MK-801) pretreatment and acute cold-restraint stress (CRS) in pentylenetetrazole (PTZ)-induced seizures in Swiss albino mice." | 3.74 | Influence of sex on the interaction between dizocilpine (MK-801) pretreatment and acute cold-restraint stress in epilepsy susceptibility in an animal study. ( Aksu, F; Inan, SY, 2008) |
| "BmK IT2 showed anticonvulsant activity as it inhibited the widespread seizures induced by PTZ and pilocarpine-induced SE in rats." | 3.74 | Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy. ( Ji, YH; Jiang, LL; Shu, XQ; Weng, CC; Yang, J; Zhang, JW; Zhang, XY; Zhao, R, 2008) |
| "A series of appropriate alkanolamine and amide derivatives of xanthone were prepared and evaluated for anticonvulsant activity using maximal electroshock (MES) and subcutaneous pentylenetetrazole (scMet) induced seizures, and for neurotoxicity (TOX) using the rotorod test on mice and rats." | 3.74 | Anticonvulsant activity of some xanthone derivatives. ( Antkiewicz-Michaluk, L; Marona, H; Pekala, E; Szneler, E; Walczak, M, 2008) |
| " In ovariectomized Swiss mice, the threshold for seizures induced by intravenous infusion of pentylenetetrazole was determined after treatment with progesterone (25, 50, or 75 mg/kg, given subcutaneously 6h before seizure testing) or vehicle." | 3.74 | Role of nitric oxide in the anticonvulsive effect of progesterone. ( Dehpour, AR; Gholipour, T; Jabbarzadeh, A; Nezami, BG; Rasouli, A; Riazi, K; Sharifzadeh, M, 2008) |
| " Isobolographic analysis was used in two mouse experimental models of epilepsy: the maximal electroshock seizure threshold test and pentylenetetrazole-induced seizures." | 3.74 | Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2008) |
| "Pasipay could dose-dependently affected minimal clonic seizures and generalized tonic-clonic seizures induced by pentylenetetrazole, through increment in seizure onset significantly." | 3.74 | Possible role of GABAA-benzodiazepine receptor in anticonvulsant effects of Pasipay in rats. ( Nassiri-Asl, M; Shariati-Rad, S; Zamansoltani, F, 2008) |
| "Oleamide exhibits antiepileptic activity and significantly decreases the degree of pentylenetetrazole-induced seizures." | 3.74 | Effect of oleamide on pentylenetetrazole-induced seizures in rats. ( Abkhazava, D; Avaliani, N; Kiguradze, T; Kuchiashvili, N; Mamulaishvili, I; Mikautadze, E; Mikeladze, E; Nozadze, M; Pkhakadze, V; Solomonia, R, 2008) |
| " In the absence of other, more efficacious treatment methods, these therapies-such as insulin coma or atropine coma-brought at least some relief to those who suffered from serious mental disorders." | 3.74 | A few facts from the history of selected biological treatment methods in psychiatry. ( Jarema, M, 2008) |
| "Intramuscular injection of selective NMDA receptor antagonists memantine and arcaine 4-fold decreased the incidence of pentylenetetrazole-induced generalized tonic-clonic seizures in rats, while the incidence of clonic seizures decreased by 1." | 3.74 | Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia. ( Gmiro, VE; Serdyuk, SE, 2008) |
| " Dumont (Polygalaceae) were evaluated for anticonvulsant activity against tonic seizures produced in mice by pentylenetetrazole (PTZ), bicuculline, picrotoxin, and N-methyl-DL-aspartic acid (NMDLA)." | 3.74 | Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice. ( Amabeoku, G, 2008) |
| "The present study was aimed to evaluate a liposomal formulation of amiloride on experimental seizure models including the increasing current electroshock seizure threshold test (ICES), pentylenetetrazole (PTZ)-induced seizures and PTZ-induced status epilepticus in mice." | 3.74 | Comparative efficacy of liposome-entrapped amiloride and free amiloride in animal models of seizures and serum potassium in mice. ( Ali, A; Dua, Y; Iqbal Khan, Z; Jalees Ahmad, F; Kolappa Pillai, K; Vohora, D, 2007) |
| " In the present study, we examined the ability of diazepam to reduce pentylenetetrazoLe (PTZ)-induced and maximal electroshock (MES)-induced seizures in mice containing point mutations in single (alpha1H101R, alpha2H101R or alpha5H105R) or multiple (alpha125H-->R) alpha subunits that render the resulting GABA(A) receptors diazepam-insensitive." | 3.74 | Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. ( Atack, JR; Bull, S; Dawson, GR; Fradley, RL; Garrett, EM; Goodacre, SC; Guscott, MR; Hallett, DJ; Newman, RJ; O'Meara, GF; Reynolds, DS; Rosahl, TW; Wafford, KA; Whiting, PJ, 2007) |
| "The anticonvulsant effects of benzyl- and benzhydryl ureides in mice models of seizures (maximal electroshock seizure test, pentylenetetrazol test, picrotoxin-induced seizure test) and the influence on spontaneous locomotor activity has been assessed." | 3.74 | Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides. ( Gütschow, M; Kubacka, M; Librowski, T; Meusel, M; Müller, CE; Scolari, S, 2007) |
| " Tyrianthin 6 (6), scammonin 1 (8), and scammonin 2 (9) exhibited dose-dependent protective effects against pentylenetetrazole-induced seizures." | 3.74 | Resin glycosides from the roots of Ipomoea tyrianthina and their biological activity. ( Aguirre-Crespo, F; Estrada-Soto, S; Herrera-Ruiz, M; León-Rivera, I; Mirón-López, G; Vazquez-Navarrete, L, 2007) |
| "In the present study, we used both histidine decarboxylase-deficient (HDC-KO) mice and wild-type (WT) mice to elucidate the possible role of carnosine in pentylenetetrazol (PTZ)-induced seizures." | 3.74 | Carnosine inhibits pentylenetetrazol-induced seizures by histaminergic mechanisms in histidine decarboxylase knock-out mice. ( Chen, Z; Liu, LY; Ohtsu, H; Wang, S; Wu, DC; Zhu, YY; Zhu-Ge, ZB, 2007) |
| " (Crassulaceae) was investigated by studying the effects of both aqueous and methanol extracts of the plant species on seizures induced by pentylenetetrazole, bicuculline, picrotoxin and N-methyl-dl-aspartic in mice." | 3.74 | Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice. ( Amabeoku, GJ; Green, I; Kabatende, J, 2007) |
| "In the present work, we studied the effects of piplartine (PIP), an amide alkaloid isolated from the roots of Piper tuberculatum (Piperaceae), in the elevated plus maze, open field, rota rod, pentylenetetrazole (PTZ)-induced seizures, and forced swimming tests, in mice (Swiss, male, 25 g) to assess anxiolytic, sedative, muscle relaxant, anticonvulsant and antidepressant effects, respectively." | 3.74 | Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice. ( Alexandre Silveira, J; Cícero Bezerra Felipe, F; de Barros Viana, GS; de Oliveira Souza, LE; Deusdênia Loiola Pessoa, O; Esdras de Andrade Uchoa, D; Rocha Silveira, E; Trajano Sousa Filho, J, 2007) |
| "To investigate the modulatory effects of morphine on the susceptibility to pentylenetetrazole-induced seizures, and the involvement of endogenous histamine in this process." | 3.74 | [Involvement of endogenous histamine in modulatory effect of morphine on seizure susceptibility in mice]. ( Chen, Z; Jin, CL; Wu, DC; Zhu, YY; Zhu-Ge, ZB, 2007) |
| " We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg/kg or 70 mg/kg of pentylenetetrazole (PTZ); the anticonvulsant effect of thalidomide was also compared with that of valproic acid." | 3.74 | Thalidomide inhibits pentylenetetrazole-induced seizures. ( Calderon, A; Palencia, G; Sotelo, J, 2007) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 3.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| "Seizures were induced with pentylenetetrazole (PTZ)." | 3.74 | A large-scale mutagenesis screen to identify seizure-resistant zebrafish. ( Baraban, SC; Castro, PA; Chege, S; Dinday, MT; Guyenet, S; Taylor, MR, 2007) |
| " Furthermore, pretreatment with sarcosine was effective in controlling pentylenetetrazol-induced seizures." | 3.74 | Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. ( Fei, D; Gong, N; Xu, L; Xu, TL; Zhang, LH, 2008) |
| " The anticonvulsant activity of all the synthesized compounds was evaluated against maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (ScPTZ) induced seizure models in mice." | 3.74 | Synthesis and anticonvulsant activity of some novel 3-aryl amino/amino-4-aryl-5-imino-Delta2-1,2,4-thiadiazoline. ( Gupta, A; Jatav, V; Kashaw, SK; Mishra, P; Stables, JP, 2008) |
| ") against pentylenetetrazole (PTZ)-, picrotoxin (PCT)- and bicuculline (BCL)-induced seizures in mice." | 3.74 | Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ('African potato') aqueous extract in mice. ( Ojewole, JA, 2008) |
| "Both opioid and cannabinoid CB(1) receptors may be involved in the dramatic increase in pentylenetetrazole-induced seizure threshold in cholestasis." | 3.74 | Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems. ( Dehpour, AR; Ghasemi, M; Shafaroodi, H, 2008) |
| "Domoic acid (DA) is a neurotoxin produced by diatoms of the genus Pseudo-nitzschia that targets the limbic system to induce tonic-clonic seizures and memory impairment." | 3.74 | Embryonic exposure to domoic Acid increases the susceptibility of zebrafish larvae to the chemical convulsant pentylenetetrazole. ( Ramsdell, JS; Tiedeken, JA, 2007) |
| "We studied the effect of myo-inositol on pentylenetetrazole and kainic acid-induced seizures in rats." | 3.74 | Effect of myo-inositol on convulsions induced by pentylenetetrazole and kainic acid in rats. ( Bolkvadze, T; Kigyradze, T; Kiladze, M; Kuchiashvili, N; Nozadze, M; Pkhakadze, V; Solomonia, R; Zhvania, M, 2007) |
| " Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels." | 3.74 | Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. ( Rensing, N; Rothman, SM; Thio, LL; Weisenfeld, AE; Wong, M; Xu, L; Yamada, KA; Yang, XF; Zhang, HX, 2008) |
| ") against pentylenetetrazole (PTZ)-, picrotoxin (PCT)- and bicuculline (BCL)-induced seizures in mice." | 3.74 | Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract. ( Ojewole, JA, 2008) |
| " The threshold to generalized clonic seizures induced by timed intravenous infusion of pentylenetetrazole (PTZ) was used as an index of seizure propensity." | 3.74 | Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide. ( Dehpour, AR; Doratotaj, B; Gholipour, T; Honar, H; Jannati, A; Nik, HH; Noorian, AR; Riazi, K; Shariftabrizi, A, 2008) |
| " rupestris (100 mg/kg, intraperitoneally) in pentylenetetrazole-induced seizures on mice." | 3.74 | Neuropharmacological effects in mice of Lychnophora species (Vernonieae, Asteraceae) and anticonvulsant activity of 4,5-di-O-[E]-caffeoylquinic acid isolated from the stem of L. rupestris and L. staavioides. ( Lopes, JL; Lopes, NP; Mortari, MR; Santos, WF; Taleb-Contini, SH, 2008) |
| " Some selected compounds were assayed against seizures induced by pentylenetetrazole (PTZ) and strychnine in mice." | 3.74 | Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents. ( Al-Eryani, YA; Amin, KM; Rahman, DE, 2008) |
| "To characterize the anticonvulsant effects and types of interactions exerted by mixtures of vigabatrin (VGB) and conventional antiepileptic drugs (valproate (VPA), ethosuximide (ESM), phenobarbital (PB), and clonazepam (CZP)) in pentylenetetrazole (PTZ)-induced seizures in mice, the isobolographic analysis for three fixed-ratio combinations of 1 : 3, 1 : 1, and 3 : 1 was used." | 3.73 | Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Andres, MM; Czuczwar, SJ; Luszczki, JJ; Wojcik-Cwikla, J, 2005) |
| "The effects of tianeptine and fluoxetine on pentylenetetrazole (PTZ)-induced seizures in rats were investigated." | 3.73 | Investigation of the effects of tianeptine and fluoxetine on pentylenetetrazole-induced seizures in rats. ( Ceyhan, M; Kayir, H; Uzbay, IT, 2005) |
| "The aim of this study was to examine the effects of acute fluoxetine treatment on pentylenetetrazol-induced convulsions in order to shape a model of seizures associated with treatment with antidepressants in rats." | 3.73 | The effect of fluoxetine in a model of chemically induced seizures--behavioral and immunocytochemical study. ( Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Taracha, E; Wisłowska, A; Zienowicz, M, 2005) |
| "One hour after treatment with normal saline, or one of the three ginseng preparations, seizures were induced in adult, male, Sprague-Dawley rats with kainic acid (KA; 10 mg/kg), pilocarpine (300 mg/kg, preceded by methylscopolamine, 1 mg/kg, s." | 3.73 | Anticonvulsant activity of ginseng on seizures induced by chemical convulsants. ( Lian, XY; Stringer, JL; Zhang, ZZ, 2005) |
| " Lower doses of valproate and carbamazepine were required to prevent hyperactivity compared to doses required to block tonic-clonic seizures induced by pentylenetetrazole." | 3.73 | Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. ( Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L, 2005) |
| "The anticonvulsant activity of acetone extract of the seeds of Heracleum persicum (Umbelliferae) was examined against pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures in mice." | 3.73 | Anticonvulsant activity of Heracleum persicum seed. ( Kamalinejad, M; Moaied, S; Sayyah, M, 2005) |
| " The mice displayed increased anxiety-like behaviour in several tests including elevated plus-maze and were more susceptible to pentylenetetrazole-induced seizures." | 3.73 | Behavioural phenotypes of hypomorphic KCC2-deficient mice. ( Airaksinen, MS; Rauvala, H; Savilahti, H; Tornberg, J; Voikar, V, 2005) |
| "5 hours later by administration of saline vehicle or a regimen of bicuculline (1 mg/kg, sc), a GABA(A) receptor antagonist, which does not produce any intrinsic effects on seizures." | 3.73 | Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins. ( Frye, CA; Rhodes, ME, 2005) |
| "NEF inhibited electroshock-induced seizures at nontoxic doses, whereas it had no effect on seizures chemically induced by pentylenetetrazole, bicuculline, picrotoxin, strychnine, or N-methyl-D-aspartate." | 3.73 | Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats. ( Kitano, Y; Komiyama, C; Makino, M; Sakurada, S; Takasuna, K; Takazawa, A, 2005) |
| " The thresholds for the clonic seizures induced by the intravenous administration of gamma-aminobutyric acid (GABA)-antagonist, pentylenetetrazole (PTZ) were assessed in mice." | 3.73 | The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors. ( Dehpour, AR; Ebrahimkhani, MR; Ghaffari, K; Homayoun, H; Honar, H; Jannati, A; Kiani, S; Noorian, AR; Rashidi, N; Riazi, K, 2005) |
| "In the present study, we investigated the effects of micro-injecting 2-chloroadenosine (2-CADO; an adenosine receptor agonist) into the thalamus alone and with theophylline (a nonspecific adenosine receptor antagonist) pretreatment on pentylenetetrazol (PTZ)-induced tonic-clonic seizures in male Wistar albino rats." | 3.73 | Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application. ( Ates, N; Ilbay, G; Sahin, D, 2005) |
| "), status epilepticus (SE) of limbic seizures produced by kainic acid (KA, 10 mg/kg, i." | 3.73 | 5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats. ( González-Trujano, ME; Hong, E; López-Meraz, ML; Neri-Bazán, L; Rocha, LL, 2005) |
| " To test this idea, we assessed the effects of chronic administration (via osmotic minipump) of the selective NET inhibitor reboxetine on flurothyl-induced seizures in mice." | 3.73 | The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice. ( Ahern, TH; Eagles, DA; Javors, MA; Liles, LC; Martillotti, J; Mitchell, HA; Weinshenker, D, 2006) |
| " Two experiments investigated effects of different estrogen-priming regimen (Experiment 1--10 microg; Experiment 2--2 microg) on pentylenetetrazole (PTZ)-induced seizures and levels of estrogen, progesterone and allopregnanolone in plasma and hippocampus." | 3.73 | Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone. ( Frye, CA; Rhodes, ME, 2005) |
| " Anticonvulsant and acute neurotoxic adverse effect profiles of combinations of GBP and TGB with other AEDs at fixed ratios of 1:3, 1:1 and 3:1 were investigated in pentylenetetrazole (PTZ)-induced seizures and the chimney test (as a measure of motor impairment) in mice so as to identify optimal combinations." | 3.73 | Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ, 2005) |
| "Isobolographic analysis was used to characterize the interactions between loreclezole (LCZ) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced seizures and in producing acute neurotoxic adverse effects in the chimney test in mice so as to identify optimum combinations." | 3.73 | Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures." | 3.73 | Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanisms. ( Li, JX; Liu, KL; Liu, YQ; Ruan, JX; Wang, YA; Yue, YJ; Zheng, JQ; Zhou, WX, 2005) |
| "The aim of this work was to study the effects of prolonged exposure to lead on the threshold of experimental seizures induced by pentylenetetrazole (PTZ)." | 3.73 | Prolonged exposure to lead lowers the threshold of pentylenetetrazole-induced seizures in rats. ( Arrieta, O; García-Arenas, G; Hernández-Pedro, N; Morales-Espinosa, D; Palencia, G; Sotelo, J, 2005) |
| " Thresholds for producing seizures in brain-derived neurotrophic factor wild-type and brain-derived neurotrophic factor heterozygous mice were compared in several seizure models, including thresholds for electrically-induced clonic, tonic-clonic and 6 Hz limbic seizures, as well as seizures induced chemically by kainate, pilocarpine and pentylenetetrazol." | 3.73 | The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice. ( Barton, ME; Shannon, HE, 2005) |
| "Structural changes in neurons and oxidative stress in hippocampus were studied in rats "tolerant" (TR) and susceptible (SR) to tonic and clonic seizures in pentylenetetrazole (PTZ) kindling." | 3.73 | [Pentylenetetrazole kindling in rats: whether neurodegeneration is associated with manifestations of seizure activity?]. ( Guliaeva, NV; Iakovleva, AA; Pavlova, TV; Stepanichev, MIu, 2005) |
| ") in mice chronically treated with temazepam or diazepam induced the appearance of withdrawal signs: clonic seizures, tonic convulsions and death episodes." | 3.73 | Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. ( Fidecka, S; Listos, J; Malec, D, 2005) |
| "This study assesses the use of the serial day Rapid Kindling with Recurrent Hippocampal Seizures (RKRHS) model in drug testing by investigating the anti-epileptic effect of levetiracetam (LEV), a novel anti-epileptic drug (AED) with a unique preclinical profile." | 3.73 | Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam. ( Boon, P; Claeys, P; De Smedt, T; Dedeurwaerdere, S; Legros, B; Raedt, R; Vonck, K; Wadman, W; Wyckhuys, T, 2005) |
| "001) delayed the onset of, and antagonized, pentylenetetrazole (PTZ)-induced seizures." | 3.73 | Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice. ( Ojewole, JA, 2005) |
| " In the present study, the involvement of NO pathway in the anticonvulsant effect of melatonin in pentylenetetrazole (PTZ)-induced clonic seizures was investigated in mice." | 3.73 | Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2006) |
| "We investigated the effects of lipopolysachharide (LPS) on functional and structural properties of the blood-brain barrier (BBB) during pentylenetetrazole (PTZ)-induced epileptic seizures in rats." | 3.73 | Effects of lipopolysaccharide on blood-brain barrier permeability during pentylenetetrazole-induced epileptic seizures in rats. ( Ahishali, B; Arican, N; Bilgic, B; Elmas, I; Gurses, C; Kalayci, R; Kaya, M; Kucuk, M; Uzun, H; Uzun, M, 2006) |
| "We investigated whether the severity of blood-brain barrier disruption caused by pentylenetetrazole-induced seizures is modified by long-term nitric oxide synthase inhibition in rats." | 3.73 | Long-term L-NAME treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats. ( Ahishali, B; Arican, N; Elmas, I; Kalayci, R; Kaya, M; Kucuk, M, 2006) |
| " Pharmacological effects were tested on ambulatory activity, anti-anxiety response, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced seizures in comparison to honokiol, buspirone, ethosuximide and diazepam as corresponding reference drugs." | 3.73 | Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. ( Chávez, M; Domínguez, F; González, M; González-Trujano, ME; Martínez, AL; Orozco, S; Salgado, H, 2006) |
| " A crude extract was given systemically and its effects were tested on pentylenetetrazole (PTZ)-induced seizures, sodium pentobarbital-induced hypnosis, exploratory activity, anxiety and nociception." | 3.73 | Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice. ( Carrera, D; Cedillo-Portugal, E; Gonzalez-Trujano, ME; Navarrete, A; Ventura-Martinez, R, 2006) |
| "Anticonvulsant activity of allopregnanolone, a neurosteroid allosterically modulating GABA(A) receptor was tested in a model of motor seizures elicited by pentetrazol in immature rats." | 3.73 | Anticonvulsant action of allopregnanolone in immature rats. ( Haugvicová, R; Kasal, A; Mares, P; Mikulecká, A, 2006) |
| " This study evaluated the neuroprotective activity of citronellol on pentylenetetrazol- and picrotoxin-induced convulsions and maximal electroshock-induced seizures in mice." | 3.73 | Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents. ( Araújo, DA; Cruz, JS; de Almeida, RN; de Sousa, DP; Gonçalves, JC; Quintans-Júnior, L, 2006) |
| " Pentylenetetrazole (PTZ)-induced seizures were used to evaluate the anticonvulsant effect of drugs." | 3.73 | Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine. ( Pillai, KK; Uma Devi, P; Vohora, D, 2006) |
| "The effects of chloroquine on glial fibrillary acidic protein (GFAP), proliferation cell nuclear antigen (PCNA) and Cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole (PTZ) were observed in the present study." | 3.73 | Effects of chloroquine on GFAP, PCNA and cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole. ( Liu, Q; Wang, W; Zhang, S; Zhu, C, 2005) |
| " Increasing current electroshock test (ICES), pentylenetetrazole (PTZ)-induced seizures, forced swim test (FST), passive avoidance response (PAR), spontaneous alternation behaviour (SAB) and elevated plus maze (EPM) were used for studying the acute effects of sparfloxacin while ICES, grip strength test (GST) and urinary hydroxyproline estimations were done for studying its chronic effects." | 3.73 | Effects of sparfloxacin on CNS functions and urinary hydroxyproline in mice. ( Bharal, N; Pillai, KK; Vohora, D, 2006) |
| "The effect of the selective 5-hydroxytryptamine1B (5-HT1B) receptor agonist 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine (CP 94253) and the 5-HT1A/1B/1D receptor agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole (RU 24969) in maximal electroshock- and pentylenetetrazol-induced seizures in mice was examined." | 3.73 | Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice. ( Chojnacka-Wójcik, E; Nikiforuk, A; Wesołowska, A, 2006) |
| ") against pentylenetetrazole (PTZ)-, picrotoxin (PCT)- and bicuculline (BCL)-induced seizures in mice." | 3.73 | Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice. ( Amabeoku, GJ; Ojewole, JA, 2006) |
| "0 mg/kg) as well as increasing the threshold to electrically- and pentylenetetrazole-induced seizures (TID(10)s 7." | 3.73 | In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. ( Anderson, NJ; Slough, S; Watson, WP, 2006) |
| " When administered in a formulation specifically designed to achieve relatively constant plasma drug concentrations, and therefore maintain selective occupancy of alpha5- compared to alpha1-, alpha2- and alpha3-containing receptors (75+/-4% versus 22+/-10%, respectively), L-655,708 did not alter the dose of pentylenetetrazole required to induce seizures, indicating that the inverse agonist effects of L-655,708 at the alpha5 subtype are not associated with a proconvulsant liability." | 3.73 | L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors. ( Atack, JR; Bayley, PJ; Dawson, GR; McKernan, RM; Seabrook, GR; Wafford, KA, 2006) |
| "6 microg/microl) effectively prevented seizures induced by the unilateral GABAergic blockade of Area tempestas (bicuculline, 0." | 3.73 | Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae). ( Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR, 2006) |
| "Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.73 | Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| " This study shows that substitution on the N-terminus confers the greatest antiseizure activity, particularly against pilocarpine-induced seizures." | 3.72 | N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities. ( Tan, CY; Wainman, D; Weaver, DF, 2003) |
| "This work evaluates the seizure susceptibility of nai;ve female Wistar Audiogenic rats (WARs), a genetic model of reflex epilepsy in which seizures are induced by high-intensity sound stimulation (120 dB SPL), to other pro-convulsive stimuli: transauricular electroshock (ES), pentylenetetrazole (PTZ) and pilocarpine (PILO)." | 3.72 | Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine. ( Doretto, MC; Magalhães, LH; Moraes, MF; Scarlatelli-Lima, AV, 2003) |
| "The effect of methanolic extract of Asparagus pubescens was investigated on chemical, thermal-induced pain as well as fresh egg albumin-induced inflammation and pentylenetetrazol (PTZ)-induced convulsion in rodents." | 3.72 | Anti-nociceptive and anti-inflammatory effects of methanolic extract of Asparagus pubescens root in rodents. ( Nwafor, PA; Okwuasaba, FK, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by both 14 mg/kg of 4-aminopyridine and 110 mg/kg of pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 3.72 | Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Bravo, J; Cuadrado, A, 2003) |
| "We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was proconvulsive in this respect." | 3.72 | Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures. ( Ashkenazi, S; Weizman, A; Yuhas, Y, 2003) |
| "The objective of this study was to evaluate the interaction of the novel antiepileptic drug (AED), topiramate (TPM), with conventional AEDs against amygdala-kindled seizures in rats and pentylenetetrazol-induced convulsions in mice." | 3.72 | Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. ( Borowicz, KK; Czuczwar, SJ; Duda, AM; Luszczki, JJ, 2003) |
| "Seizures were induced in rats by intraperitoneal injection of pentylenetetrazole (PTZ, 70 mg/kg), followed, 30 min later, by injection of [1-13C]glucose and [1,2-13C]acetate." | 3.72 | Pentylenetetrazole decreases metabolic glutamate turnover in rat brain. ( Dahl, CB; Eloqayli, H; Götestam, KG; Hadidi, H; Sonnewald, U; Unsgård, G, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| "We examined the effect of melatonin on brain levels of amino acids and nitric oxide (NO) after pentylenetetrazole (PTZ)-induced seizures in rats." | 3.72 | Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. ( Acuña-Castroviejo, D; Bikjdaouene, L; Escames, G; Ferrer, JM; Khaldy, H; León, J; Vives, F, 2003) |
| "0 mg kg(-1), significantly and dose-dependently inhibited the seizures induced by pentylenetetrazole." | 3.72 | Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. ( Li, CL; Song, HR; Wang, YL; Wu, CF; Yang, JY; Zhang, HF, 2003) |
| " The doses increased the latency time to convulsions induced by picrotoxin and pilocarpine but prevented the onset of pentylenotetrazol and strychnine induced seizures." | 3.72 | Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L. ( Carvalho, JC; Carvalho, JE; Perazzo, FF; Rehder, VL, 2003) |
| "Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA) respectively." | 3.72 | Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1. ( Fei, J; Guo, LH; Ma, YH; Mei, ZT; Zhao, WJ, 2003) |
| " To assess the responsiveness of all new neurons we also analysed the expression patterns of three IEGps (c-fos, zif268 and Homer1A) after kainic acid (KA)- or pentylenetetrazol (PTZ)-induced seizures." | 3.72 | Adult-born hippocampal neurons mature into activity-dependent responsiveness. ( Jessberger, S; Kempermann, G, 2003) |
| "The purpose of this study was to investigate whether or not clobenpropit, a selective and potent histamine H(3) receptor antagonist, can protect from pentylenetetrazole (35 mg/kg)-kindled seizures in rats." | 3.72 | Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats. ( Chen, J; Chen, Z; Leurs, R; Ren, K; Timmerman, H; Wei, E; Ye, B; Zhang, L; Zhang, W, 2003) |
| "The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice." | 3.72 | Effect of harmane on the convulsive threshold in epilepsy models in mice. ( Aricioglu, F; Berkman, K; Korcegez, E; Yillar, O, 2003) |
| " Three days after pentylenetrazol (PTZ)-induced generalized seizures, rats received 5-bromodeoxyuridine (BrdU) injections to label dividing cells, followed 4 weeks later by the second PTZ injection to induce second episode of generalized seizures." | 3.72 | Response of seizure-induced newborn neurons in the dentate gyrus of adult rats to second episode of seizures. ( Jiang, W; Sheerin, AH; Wang, JC; Zhang, X; Zhang, Z, 2004) |
| " 3alpha-Androstanediol protected mice against seizures induced by GABAA receptor antagonists pentylenetetrazol, picrotoxin, and beta-carboline ester in a dose-dependent fashion." | 3.72 | Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol. ( Reddy, DS, 2004) |
| " After a single injection of PTZ at a dose evoking clonic-tonic seizures, PBN did not modify either the formation of free hydroxyl radicals measured by the levels of 2,3-dihydroxybenzoic acid (DHBA) and 2,5-DHBA or the susceptibility to PTZ." | 3.72 | The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone. ( Keilhoff, G; Krug, M; Rauca, C; Wiswedel, I; Zerbe, R, 2004) |
| "The decoction of Mimosa pudica leaves given intraperitoneally at dose of 1000-4000 mg/kg protected mice against pentylentetrazol and strychnine-induced seizures." | 3.72 | Anticonvulsant activity of Mimosa pudica decoction. ( Dawack, DL; Herrling, P; Jeker, A; Ngo Bum, E; Olpe, HR; Portet, C; Rakotonirina, A; Rakotonirina, SV; Schmutz, M, 2004) |
| "The authors' previous studies have shown that in nicotine-induced seizures sensitivity was decreased and blood-brain barrier (BBB) disruption was prevented as a consequence of nicotine pretreatment." | 3.72 | Tolerance to pentylentetrazol-induced convulsions and protection of cerebrovascular integrity by chronic nicotine. ( Bahçekapili, N; Diler, AS; Uzüm, G; Ziylan, YZ, 2004) |
| " The essential oil exerted dose- and time-dependent antiseizure activity in both maximal electroshock (MES) and pentylenetetrazole models of experimental seizures with ED50 values of 0." | 3.72 | Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil. ( Kamalinejad, M; Nadjafnia, L; Sayyah, M, 2004) |
| "The threshold for the clonic seizures (CST) induced by acute intravenous administration of gamma-aminobutyric acid (GABA)-antagonist pentylenetetrazole (PTZ) was assessed in male and female mice." | 3.72 | Sex and estrus cycle differences in the modulatory effects of morphine on seizure susceptibility in mice. ( Dehghani, M; Dehpour, AR; Gaskari, SA; Homayoun, H; Honar, H; Rashidi, N; Riazi, K; Sadeghipour, H, 2004) |
| " The present study was undertaken to examine the role of ALLO in the anticonvulsant action of fluoxetine against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.72 | Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice. ( Chopde, CT; Hirani, K; Mittal, N; Ugale, RR, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "The kynurenine pathway converts tryptophan into various compounds, including l-kynurenine, which in turn can be converted to the excitatory amino acid receptor antagonist kynurenic acid, which may therefore serve as a protective agent in such neurological disorders as epileptic seizures." | 3.72 | Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study. ( Farkas, T; Janáky, T; Kis, Z; Marosi, M; Németh, H; Robotka, H; Rózsa, E; Somlai, C; Toldi, J; Vécsei, L, 2004) |
| " Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsions in mice." | 3.71 | Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M, 2002) |
| "A 10 mmol/kg injection of acetone suppressed seizures in 60% of rats (P<0." | 3.71 | Ketogenic diet: does acetone stop seizures? ( Burnham, WM; Likhodii, SS, 2002) |
| "The novel putative anticonvulsant drug 1-[2,6-difluorophenyl)-methyl]-1H-1,2,3-triazolo[4,5-c]) pyridine-4-amine monohydrochloride (BW534U87) effectively reduced seizures induced in rodents by threshold maximal and supramaximal electroshock, electrical kindling, pentylenetetrazole (PTZ) infusion and by vestibular stimulation in the genetically seizure-prone epilepsy-like (EL) mouse." | 3.71 | Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism. ( Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC, 2002) |
| " Anticonvulsant effects were evaluated against seizures induced by both 4-aminopyridine and pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 3.71 | Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Cuadrado, A; de las Cuevas, I; Valdizán, EM, 2002) |
| " The compounds were assayed against seizures induced by maximal electroshock (MES) and pentylenetetrazole (scMet)." | 3.71 | Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines. ( Kishore Gnanasam, S; Leonard, JT; Ramachandran, S; Sivakumar, R, 2002) |
| " The aim of this study was to examine an interaction of lidocaine, articaine and mepivacaine with some antihypertensive drugs clonidine and reserpine on the pentylenetetrazole induced seizures." | 3.71 | Interaction between local anesthetics and centrally acting antihypertensive drugs. ( Borzecki, A; Pikuła, A; Sieklucka-Dziuba, M; Zółkowska, D, 2002) |
| "The effects of a common industrial solvent, trichloroethylene (TCE), which was once used as an anesthetic agent but its in vivo mechanism is still unknown, on convulsant-induced seizures in mice were examined." | 3.71 | Acute exposure to trichloroethylene differentially alters the susceptibility to chemoconvulsants in mice. ( Chen, HH; Chiu, TH; Shih, CL, 2001) |
| "In mice VGD afforded complete protection against maximal electroshock (MES)-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz "psychomotor" seizures with median effective dose (ED50) values of 151, 132, 275, 248, and 237 mg/kg, respectively." | 3.71 | Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. ( Bialer, M; Isoherranen, N; White, HS; Woodhead, JH, 2001) |
| " Dbh -/- mice are hypersensitive to pentylenetetrazole (PTZ)-induced seizures, demonstrating that endogenous NE inhibits PTZ-induced seizures in the wild type." | 3.71 | Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine. ( Miller, NS; Palmiter, RD; Szot, P; Weinshenker, D, 2001) |
| " Seizures were induced by timed infusion of pentylenetetrazole (PTZ) and maximal electroshock (MES)." | 3.71 | Comparison of the anticonvulsant efficacies and neurotoxic effects of valproic acid, phenytoin, and the ketogenic diet. ( Bough, KJ; Eagles, DA, 2001) |
| "Four dihydropyridine calcium channel antagonists were compared for their ability to protect against the hyperexcitability produced in mice by withdrawal from chronic ethanol treatment and to protect against seizures due to bicuculline or pentylenetetrazol." | 3.71 | Selectivity of the protective effects of dihydropyridine calcium channel antagonists against the ethanol withdrawal syndrome. ( Little, HJ; Watson, WP, 2002) |
| "Based on these findings, both opioid receptors and nitric oxide may be involved in the dramatic increase in pentylenetetrazole-induced seizure threshold in cholestasis." | 3.71 | The additive effect of opioids and nitric oxide in increasing pentylenetetrazole-induced seizure threshold in cholestatic mice. ( Dehpour, AR; Homayoun, H; Sayyah, M, 2002) |
| "In mice, M-TMCD afforded protection against maximal electroshock (MES)-induced, pentylenetetrazol (Metrazol)-induced, and bicuculline-induced seizures, as well as against 6-Hz "psychomotor" seizures and sound-induced seizures with ED50 values of 99, 39, 81, 51, and 10 mg/kg, respectively." | 3.71 | Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug. ( Barton, ME; Bennett, GD; Bialer, M; Finnell, RH; Isoherranen, N; White, HS; Wilcox, KS; Woodhead, JH; Yagen, B, 2002) |
| "Molsidomine (25 mg kg(-1)), a donor of nitric oxide, commonly used in the treatment of coronary artery disease, enhanced the protective activity of valproate against the clonic phase of pentylenetetrazole-induced seizures in mice, significantly reducing the ED(50) of valproate from 123." | 3.71 | Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. ( Arent, K; Kleinrok, Z; Tutka, P; Wielosz, M; Łuszczki, J, 2002) |
| " In previous studies, we demonstrated that Stx and lipopolysaccharide (LPS) act in concert to enhance mice sensitivity to pentylenetetrazole (PTZ)-induced seizures via mechanisms involving tumor necrosis factor alpha (TNFalpha), interleukinl beta and nitric oxide." | 3.71 | Enhancement of pentylenetetrazole-induced seizures by Shigella dysenteriae in LPS-resistant C3H/HeJ mice: role of the host response. ( Ashkenazi, S; Nofech-Mozes, Y; Weizman, A; Yuhas, Y, 2002) |
| "The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats." | 3.71 | Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. ( Chaudhary, G; Gupta, YK; Srivastava, AK, 2002) |
| "Water extract of Leonotis leonurus was tested for anticonvulsant activity against seizures produced in mice by pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid (intraperitoneal injections)." | 3.71 | Anticonvulsant activity of aqueous extract of Leonotis leonurus. ( Amabeoku, GJ; Bienvenu, E; Eagles, PK; Scott, G; Springfield, EP, 2002) |
| "The involvement of endogenous opioids and nitric oxide (NO) in the anticonvulsant effects of stress against pentylenetetrazole (PTZ)- or electroconvulsive shock-induced seizures was assessed in mice." | 3.71 | The involvement of endogenous opioids and nitricoxidergic pathway in the anticonvulsant effects of foot-shock stress in mice. ( Dehpour, AR; Homayoun, H; Khavandgar, S, 2002) |
| " Finally, a delayed development of pentylenetetrazole-induced seizures (creating a high-energy demand) was observed in B-CK-/- mice." | 3.71 | Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. ( Cools, AR; Fransen, J; Heerschap, A; In 't Zandt, HJ; Jost, CR; Oerlemans, F; Streijger, F; Van Der Zee, CE; Verheij, M; Wieringa, B, 2002) |
| " To compare the CK reaction in GM and WM when ATP metabolism is high, CK reactants and reaction rates were measured in predominantly GM and WM slices in vivo in 2 and 14-day old piglets during pentylenetetrazole (PTZ) seizures using 31P nuclear magnetic resonance (NMR) 1-dimensional chemical shift imaging (CSI)." | 3.70 | In vivo phosphocreatine and ATP in piglet cerebral gray and white matter during seizures. ( Allred, E; Cook, C; Holtzman, D; Jensen, F; Khait, I; Laussen, P; Meyers, R; Mulkern, R; Tsuji, M, 1998) |
| "Nimodipine, a dihydropyridine derivative central nervous system (CNS) selective calcium channel blocker was studied at four different dosage schedules in five different models of seizures in rats." | 3.70 | Dose-finding study with nimodipine: a selective central nervous system calcium channel blocker on aminophylline induced seizure models in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1998) |
| " The obtained compounds were evaluated for anticonvulsant activity in the maximal electroshock (MES)- and subcutaneous pentylenetetrazole (scMet)-induced seizures and for neurotoxicity in the rotorod test in mice and rats." | 3.70 | Aminoalkanolic derivatives of xanthone with potential antiepileptic activity. ( Górka, Z; Marona, H; Szneler, E, 1998) |
| "Action of ethosuximide (ESI) against two types of experimental seizures elicited by systemic administration of pentylenetetrazol (PTZ) and characterized by spike-and-wave activity in the EEG was studied in immature rats 18 and 25 days old, i." | 3.70 | Ontogeny of ethosuximide action against two seizure models in rats is different. ( Mares, P, 1998) |
| " The evaluation is reported of their anticonvulsant effects, both in the audiogenic seizures test with DBA/2 mice and against the maximal electroshock- and pentylenetetrazole-induced seizures in Swiss mice." | 3.70 | 3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists. ( Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Libri, V; Quartarone, S; Zappalà, M, 1998) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 3.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| "The anticonvulsant action of NNC 711 [(1-(2-((diphenylmethylene) amino) oxy) ethyl)-1,2,4,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride], an inhibitor of the GABA transporter GAT-1, was studied in a model of pentylenetetrazol-induced motor seizures in rats 7, 12, 18, 25, and 90 days old." | 3.70 | Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. ( Haugvicová, R; Kubová, H; Mares, P, 1998) |
| " AR-R 15896AR prevented tonic seizures in rodents for up to 6 to 8 h in response to maximal electroshock (MES), 4-aminopyridine, bicuculline, or strychnine, as well as characteristic seizures following injections of N-methyl-DL-aspartic or kainic acids." | 3.70 | [S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties. ( Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML, 1999) |
| " The group I mGluR antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) dose-dependently antagonised PTZ-induced seizures with a mean ED50 value of 465 nmol." | 3.70 | Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice. ( Dalby, NO; Thomsen, C, 1998) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 3.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| "To characterize the potential interaction between the excitatory and inhibitory neurotransmitter systems, the effects of dizocilpine, CPP, and lorazepam on open-field behavior and pentylenetetrazol-induced seizures were evaluated in mice." | 3.70 | Lorazepam attenuates the behavioral effects of dizocilpine. ( Fahey, JM; Greenblatt, DJ; Pratt, JS; Pritchard, GA; Shader, RI, 1999) |
| "N(G)-nitro-L-arginine (NNA; an inhibitor of nitric oxide synthase) in a dose of 40 mg/kg impaired the protective activity of ethosuximide against the clonic phase of pentylenetetrazol-induced seizures in mice." | 3.70 | N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol. ( Czuczwar, SJ; Kleinrok, Z; Klonowski, P; Tutka, P, 1999) |
| "In this study, the effect of an essential oil of Eugenia caryophyllata (Myrtaceae), an antiepileptic remedy in Iranian folk medicine, against seizures induced by maximal electroshock (MES) or pentylenetetrazole (PTZ) in male mice was studied." | 3.70 | Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice. ( Javadi, M; Kamalinejad, M; Majzoob, S; Pourgholami, MH; Sayyah, M, 1999) |
| "This study was designed to evaluate the blood-brain barrier permeability characteristics of the WAG/Rij strain of rats that are an ideal model for human absence epilepsy, in controls and pentylenetetrazole-induced seizures conditioned to Evans blue-albumin." | 3.70 | Absence epilepsy and regional blood-brain barrier permeability: the effects of pentylenetetrazole-induced convulsions. ( Ates, N; Esen, N; Ilbay, G, 1999) |
| "The present study was designed to evaluate the effects of age on the efficacy of the ketogenic diet in suppressing seizures evoked by tail-vein infusion of pentylenetetrazole (PTZ)." | 3.70 | Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. ( Bough, KJ; Eagles, DA; Han, FT; Valiyil, R, 1999) |
| " The present study was conducted to determine if the adenosinergic system and adenosine A1 receptors are involved in the anticonvulsant action of the antiepileptic drugs phenobarbitone and carbamazepine, in pentylenetetrazole (PTZ)-induced seizures in rats." | 3.70 | Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine. ( Gupta, YK; Malhotra, J, 1999) |
| " In this study, the proconvulsant effects exhibited by a novel series of 6-desfluoroquinolones and some classic quinolones on pentylenetetrazole (PTZ)-induced seizures in mice were evaluated and compared." | 3.70 | Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in mice. ( Cecchetti, V; De Sarro, A; De Sarro, G; Fravolini, V; Naccari, F; Tabarrini, O, 1999) |
| " To examine the mechanisms underlying these seizures, we determined the impact of prior forebrain ischemia on the seizure thresholds of four convulsants with differing modes of action: lidocaine, pentylenetetrazol (PTZ), N-methyl-D-aspartate (NMDA), and picrotoxin." | 3.70 | Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat. ( Kim, DC; Todd, MM, 1999) |
| "This study investigates anticonvulsant effects of an essential oil of the fruits of Pimpinella anisum (Umbelliferae), a folkloric remedy in the Iranian traditional medicine, against seizures induced by pentylenetetrazole (PTZ) or maximal electroshock (MES) in male mice." | 3.70 | The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. ( Fanaee, GH; Javadi, M; Kamalinejad, M; Majzoob, S; Pourgholami, MH; Sayyah, M, 1999) |
| " We tested this hypothesis by examining the influence of gamma-aminobutyric acid (GABA) ergic and glutamatergic transmission in the NTS on seizures evoked by systemic and focal bicuculline and systemic pentylenetetrazol (PTZ) in rats." | 3.70 | Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999) |
| "LY 300164 [7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4, 5H)-2,3-benzodiazepine], an antagonist of AMPA/kainate receptors, at 5 mg/kg exerted a significant anticonvulsant effect, as regards seizure and afterdischarge durations in amygdala-kindled seizures in rats." | 3.70 | Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J; Szadkowski, M, 1999) |
| "We have previously shown that 1-aryl-3,5-dihydro-7, 8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (3) possess marked anticonvulsant properties and antagonize seizures induced by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) in analogy to the structurally related 1-(4-aminophenyl)-4-methyl-7, 8-methylenedioxy-5H-2,3-benzodiazepine (1, GYKI 52466), a well-known noncompetitive AMPA/kainate receptor antagonist." | 3.70 | Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists. ( Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M, 1999) |
| " In vivo tolerance was measured by a reduced ability of the alpha(1)-subunit-selective agonist zolpidem to suppress pentylenetetrazole-induced seizures." | 3.70 | Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance. ( Chen, S; Kometiani, P; Lilly, SM; Rosenberg, HC; Tietz, EI; Zeng, XJ, 1999) |
| " Results also showed that the animals fed calorie-restricted high-fat diets exhibited significant ketonemia and protection from pentylenetetrazole (PTZ)-induced seizures." | 3.70 | Higher ketogenic diet ratios confer protection from seizures without neurotoxicity. ( Bough, KJ; Eagles, DA; Yao, SG, 2000) |
| "We tested the sensitivity of PrPc knockout mice to seizures induced by single convulsant or repeated subconvulsant (kindling) doses of pentylenetetrazol (PTZ), and to status epilepticus (SE) induced by kainic acid or pilocarpine." | 3.70 | Increased sensitivity to seizures in mice lacking cellular prion protein. ( Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R, 1999) |
| "The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate." | 3.70 | Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1999) |
| " Seizure threshold was tested by intravenous infusion of pentylenetetrazole (PTZ) whereas seizure severity was determined from measuring the hindlimb extension to flexion (E/F) ratio after seizures were evoked by maximal electroshock stimulation (MES)." | 3.70 | A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion. ( Bough, KJ; Eagles, DA; Matthews, PJ, 2000) |
| " In this report, we provide pharmacologic evidence in experimental models of seizures, suggesting that somatostatin (SRIF) and neuropeptide Y (NPY) are endogenous modulators of glutamate-mediated hyperexcitability in the CNS." | 3.70 | Modulatory role of neuropeptides in seizures induced in rats by stimulation of glutamate receptors. ( Conti, M; Rizzi, M; Samanin, R; Vezzani, A, 2000) |
| " ZnT3-/- mice, which lack histochemically reactive zinc in synaptic vesicles, had slightly higher thresholds to seizures elicited by the GABA(A) antagonist, bicuculline, and no differences in seizure threshold were seen in response to pentylenetetrazol or flurothyl." | 3.70 | Seizures and neuronal damage in mice lacking vesicular zinc. ( Cole, TB; Palmiter, RD; Robbins, CA; Schwartzkroin, PA; Wenzel, HJ, 2000) |
| " All synthesized compounds were evaluated for anticonvulsant activity against maximal electroshock (MES) and subcutaneous pentylenetetrazole (ScMet) induced seizures." | 3.70 | Synthesis and preliminary anticonvulsant activity evaluation of new 2-thioxo-4,5-imidazolidinedione derivatives. ( Gürsu, E; Ozkirimli, S; Ulusoy, N, 1999) |
| " The intraperitoneal administration of pentylenetetrazole (PTZ) to rats of various ages evoked tonic-clonic seizures." | 3.70 | Delayed and blunted induction of mRNA for tissue plasminogen activator in the brain of old rats following pentylenetetrazole-induced seizure activity. ( Fischer, B; Kessler, C; Platt, D; Popa-Wagner, A; Schmoll, H, 2000) |
| "The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice." | 3.70 | Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice. ( Pal, SN; Pillai, KK; Vohora, D, 2000) |
| "The aim of this study was to evaluate the influence of 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5 H)-2,3-benzodiazepine (LY 300164), a selective non-competitive antagonist at alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptors, on the protection provided by diazepam against electrically- and chemically-evoked seizures in rodents." | 3.70 | The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z, 2000) |
| " In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures." | 3.70 | Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. ( Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 3.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| " A nearly fivefold elevation in NO content was found at the peak time of pentylenetetrazole (PTZ)-induced seizures." | 3.70 | Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures. ( Bashkatova, V; Mikoyan, V; Narkevich, V; Rayevsky, K; Vanin, A; Vitskova, G, 2000) |
| "Benzodiazepines are used to treat the anxiety associated with cocaine withdrawal, as well as cocaine-induced seizures." | 3.70 | Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression. ( Lilly, SM; Tietz, EI, 2000) |
| "The influence of progesterone and testosterone on the incidence of seizures after administration of intraperitoneal pentylenetetrazol and subcutaneous strychnine was evaluated in mice." | 3.70 | Progesterone and testosterone modulate the convulsant actions of pentylenetetrazol and strychnine in mice. ( Acevedo, X; Bustamante, D; Miranda, HE; Pesce, ME; Pinardi, G, 2000) |
| " The new compounds were found to possess anticonvulsant effects against seizures induced both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice." | 3.70 | Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones. ( Bevacqua, F; Chimirri, A; De Sarro, A; De Sarro, G; Gitto, R; Quartarone, S; Rizzo, M; Zappalà, M, 2000) |
| "The interaction of 7-nitroindazole (7-NI), a nitric oxide synthase (NOS) inhibitor, with the protective activity of conventional antiepileptics against pentylenetetrazol (PTZ)-induced seizures was tested in mice." | 3.70 | 7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J, 2000) |
| " The aim of this paper was to investigate antiepileptogenic properties of phenobarbital, focusing on the neurochemical changes associated with repeated seizures induced by low convulsive dose of pentylenetetrazol (PTZ) (60 mg/kg, sc) in mice." | 3.70 | Antiepileptogenic properties of phenobarbital: behavior and neurochemical analysis. ( Elisabetsky, E; Silva Brum, LF, 2000) |
| "The nitric oxide (NO) synthase inhibitor N omega-nitro-L-arginine (NNA) and the putative brain-selective NO synthase inhibitor 7-nitroindazole (7-NI) were used to determine the role of endogenous NO on seizures induced by kainic acid (KA) in rats and KA, pilocarpine, bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice." | 3.69 | Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. ( Davis, W; Penix, LP; Subramaniam, S, 1994) |
| " We have studied the susceptibility to bicuculline and pentylenetetrazol-induced seizures in developing 10-, 20- and 30-day old rats, gestationally exposed to cocaine." | 3.69 | Prenatal cocaine: seizure susceptibility in rat offspring. ( de Feo, MR; Del Priore, D; Mecarelli, O, 1995) |
| "In situ hybridization histochemistry for somatostatin receptors-1, -2, -3 and -4 section and receptor autoradiography using [125I]CGP 23996, [125I]somatostatin-28, [125I]seglitide and [125I]Tyr3 octreotide were carried out to determine the expression of somatostatin receptor messenger RNAs and binding sites in the hippocampus and cerebral cortex of rats 21 days following generalized limbic seizures induced by subcutaneous injection of 12mg/kg kainic acid." | 3.69 | Functional effects of D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2 and differential changes in somatostatin receptor messenger RNAs, binding sites and somatostatin release in kainic acid-treated rats. ( Civenni, G; Hoyer, D; Pérez, J; Rizzi, M; Schüpbach, E; Tutka, P; Vezzani, A, 1995) |
| " The anticonvulsant activity of the title compounds were determined against pentylenetetrazole induced seizures." | 3.69 | Synthesis and anticonvulsant activity of some new 1,1-bis(4-substituted 1,2,4-triazoline-5-thione-3-yl)-2-methylbutanes. ( Ekinci, AC; Ergenç, N; Ulusoy, N, 1995) |
| " Administration of pentylenetetrazole (PTZ; 50 mg/kg) to rats of various ages evoked tonic-clonic seizures." | 3.69 | Pentylenetetrazole-induced seizure up-regulates levels of microtubule-associated protein 1B mRNA and protein in the hippocampus of the rat. ( Bauer, J; Fischer, B; Platt, D; Popa-Wagner, A; Retchkiman, I, 1995) |
| "We measured the release of neuropeptide Y (NPY) from hippocampal slices of rats at various times after limbic seizures induced by a subcutaneous injection of 12 mg/kg kainic acid (KA)." | 3.69 | Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats. ( Civenni, G; Messali, S; Monno, A; Rizzi, M; Samanin, R; Vezzani, A, 1994) |
| "The anticonvulsant properties of a mixture of non-esterified alpha-linolenic acid and linoleic acid with a ratio of 1:4 (SR-3) were evaluated in four rat models of epileptic seizures: (1) i." | 3.69 | Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. ( Carasso, RL; Mostofsky, DI; Yehuda, S, 1994) |
| "We performed studies to determine the anatomical regions and chemical phenotypes of neurons within the rat medulla oblongata activated by pentylenetetrazole-induced seizures." | 3.69 | Activation of the c-fos gene in prodynorphin- and proenkephalin-expressing cells of nucleus tractus solitarius after seizures. ( Erickson, JT; Kanter, RK; Millhorn, DE, 1994) |
| "Pentylenetetrazole (PTZ) evoked seizures, known to be dependent on stimulation of excitatory amino acids (EAA) receptors, serve as a useful model to study genomic responses to increased brain activity." | 3.69 | AP-1 and CRE DNA binding activities in rat brain following pentylenetetrazole induced seizures. ( Kaczmarek, L; Lukasiuk, K, 1994) |
| "Oxcarbazepine (OCBZ, Trileptal) and its main human monohydroxy metabolite (MHD) protected mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13." | 3.69 | Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. ( Brugger, F; Gentsch, C; McLean, MJ; Olpe, HR; Schmutz, M, 1994) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 3.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "The purpose of this investigation was to determine whether paraplegia induced by neoplastic cord compression affects the pharmacodynamics of phenobarbital general anesthesia or of pentylenetetrazol (PTZ)-induced convulsions." | 3.69 | Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. ( Alfon, J; Hoffman, A; Siegal, T, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 3.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| "Pretreatment of mice with 30 mg xylazine/kg ip protected against convulsions induced by amphetamine, but it intensified pentylenetetrazole- and strychnine-induced seizures." | 3.69 | Pro and anticonvulsant effects of xylazine on convulsion models in rodents. ( Bernardi, MM; Gorniak, SL; Palermo-Neto, J; Spinosa, FR; Spinosa, Hde S, 1994) |
| " Systemic kainic acid (5-20 mg/kg) caused limbic-like seizures, with staring, catatonia, fasciculations, and severe motor seizures, which were almost always lethal." | 3.69 | Experimental seizures in the frog (Rana pipiens). ( Blisard, KS; Fagin, K; Falivena, P; Harrington, DA; Olejniczak, P; Privitera, MD; Scremin, OU; Taylor, KL, 1994) |
| " To test the effect of antiepileptic drugs on kindled seizures and kindling-induced learning deficits we injected ethosuximide, dipropylacetate, and phenobarbital prior to each kindling stimulation or after kindling completion, and tested these animals in a shuttle-box paradigm." | 3.69 | Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments. ( Becker, A; Brosz, M; Grecksch, G, 1995) |
| " Therefore, we used this model to study the influence of flunarizine, a calcium antagonist, on kindled seizures as well as related learning impairments." | 3.69 | Flunarizine--its effect on pentylenetetrazol-kindled seizures and on related cognitive disturbances. ( Becker, A; Grecksch, G, 1995) |
| " In addition, the plant extract delayed the onset of PTZ forelimb clonus, and generalized limbic seizures induced by kainic acid." | 3.69 | Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents. ( Baldy-Moulinier, M; N'gouemo, P; Nguemby-Bina, C, 1996) |
| "The protective effects of the selective adenosine A1 receptor agonist 2-chloro-N(6)-cyclopentyladenosine (CCPA), the selective adenosine A2A receptor agonist, 2-hexynyl-5'-N-ethylcarboxamidoadenosine (2HE-NECA), and the non-selective agonist, 5'-N-ethylcarboxamidoadenosine (NECA) were studied against lethal seizures induced by intraperitoneal (i." | 3.69 | Effects of repeated administration of selective adenosine A1 and A2A receptor agonists on pentylenetetrazole-induced convulsions in the rat. ( Adami, M; Bertorelli, R; Ferri, N; Foddi, MC; Ongini, E, 1995) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 3.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| " administration, NNC 14-0185 and NNC 14-0189 prevented audiogenic seizures in DBA/2 mice and the clonic convulsions induced in mice by pentylenetetrazole, DMCM (methyl 6, 7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate), 3-mercaptopropionic acid and a low dose of bicuculline." | 3.69 | Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice. ( Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD, 1996) |
| "The possible anticonvulsant action of baclofen, a GABAB (gamma-aminobutyric acid) receptor agonist, was studied using two types of motor seizures (minimal, clonic and generalized tonicoclonic) elicited by pentylenetetrazol in adult rats and rat pups, 7, 12, 18, and 25 days old." | 3.69 | Moderate anticonvulsant action of baclofen does not change during development. ( Haugvicová, R; Kubová, H; Mares, P, 1996) |
| " However, it did not affect seizures elicited by picrotoxin (2." | 3.69 | Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice. ( Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T, 1996) |
| "Among three calcium channel inhibitors, only nicardipine (10-40 mg/kg) significantly inhibited clonic seizures induced by pentylenetetrazol administered at its CD97 (convulsive dose 97%) of 81 mg/kg, subcutaneously." | 3.69 | Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. ( Brudniak, T; Czuczwar, SJ; Gasior, M; Kamiński, R; Kleinrok, Z, 1996) |
| " serraefolia significantly delayed the onset of tonic seizures induced by strychnine and pentylenetetrazol; besides, it diminished the death rate and number of animals that exhibited convulsions." | 3.69 | Evaluation of the calcium-antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia. ( Aguilar-Santamaría, L; Tortoriello, J, 1996) |
| "The effect of the nitric oxide synthase (NOS) inhibitors N-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI) on seizures induced by N-methyl-D-aspartate (NMDA), pilocarpine (PIL) and pentylenetetrazol (PTZ), as well as on the electroconvulsive threshold was studied in mice." | 3.69 | The role of nitric oxide in chemically- and electrically-induced seizures in mice. ( Baran, L; Przegaliñski, E; Siwanowicz, J, 1996) |
| "The effects of non-peptide AT1- and AT2-receptor antagonists DuP 753 (losartan) and PD 123319 on the intensity of pentylenetetrazol (PTZ)-kindled seizures in mice were studied." | 3.69 | Effects of non-peptide angiotensin II-receptor antagonists on pentylenetetrazol kindling in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1996) |
| " Insulin was shown to be ineffective to suppress ouabain (5 micrograms/intracerebroventricular) induced seizures." | 3.69 | Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats. ( Akarsu, ES; Ayhan, IH; Cağlar, S; Inan, LE; Kuli, P; Palaoğlu, O; Uysal, H, 1996) |
| "Pentylenetetrazole and kainic acid, seizure-inducing agents that are known to increase glucose utilization in brain, were used to produce chronic seizures in mature rats." | 3.69 | Chronic seizures increase glucose transporter abundance in rat brain. ( Drewes, LR; Gerhart, DZ; Gronlund, KM; Leino, RL; McCall, AL, 1996) |
| "Mice deficient for the fyn gene were examined for their susceptibility to seizures induced by various convulsive drugs, including pentylenetetrazol, picrotoxin, bicuculline, kainic acid, N-methyl-D-aspartate (NMDA) and strychnine." | 3.69 | Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice. ( Miyakawa, T; Niki, H; Tateishi, K; Yagi, T, 1996) |
| "5 g/l in drinking water) on bicuculline- and pentylenetetrazol (PTZ)-induced seizures and c-fos expression were studied in mice." | 3.69 | Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. ( Fredholm, BB; Georgiev, V; Johansson, B; Kuosmanen, T, 1996) |
| "The relative ability of derivatives of 2-piperidinecarboxylic acid (2-PC; pipecolic acid) and 3-piperidinecarboxylic acid (3-PC; nipecotic acid) to block maximal electroshock (MES)-induced seizures, elevate the threshold for electroshock-induced seizures and be neurotoxic in mice was investigated." | 3.69 | Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats. ( Andersen, PH; Burns, CM; Chang, H; Crider, AM; el-Assadi, AA; Hinko, CN; Ho, B; Kliem, MA; Klitgaard, H; Seo, TH; Steinmiller, CL; Tietz, EI; Venkatarangan, P, 1996) |
| "When ddY mice were pretreated with L-carnitine (5, 10 or 20 mmol/kg), clonic as well as tonic seizures induced by pentylenetetrazol (PTZ) were dose-dependently suppressed." | 3.69 | Suppression of pentylenetetrazol-induced seizures by carnitine in mice. ( Igisu, H; Ikeda, M; Iryo, Y; Matsuoka, M; Yu, Z, 1997) |
| " The seizures were evoked both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice." | 3.69 | 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. ( Chapman, AG; Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Giusti, P; Grasso, S; Libri, V; Quartarone, S; Zappalà, M, 1997) |
| " The effects of adenosine, the adenosine analogue, 2-chloroadenosine (2-CADO), the specific adenosine A1 receptor agonist, N6-cyclopentyladenosine (CPA) and A2 receptor agonist 5'-(N-cyclopropyl) carboxamidoadenosine (CPCA), were examined against seizures induced by acute administration of pentylenetetrazole (PTZ), 60 mg kg-1, and PTZ kindled seizures, in rats." | 3.69 | Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| " Disinhibition of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and/or activation of NMDA receptor appears to be factors involved in the initiation and generalization of the pentylenetetrazole (PTZ) induced seizures." | 3.69 | L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice. ( Kaputlu, I; Uzbay, T, 1997) |
| " (Myrtaceae) was studied against lethal seizures induced by intraperitoneal injection of pentylenetetrazole (80 mg/kg), picroptoxin (6 mg/kg), and strychnine (2 mg/kg) in mice." | 3.69 | The leaf essential oil of Psidium guyanensis offers protection against pentylenetetrazole-induced seizures. ( Rao, VS; Santos, FA; Silveira, ER, 1997) |
| "Brain creatine kinase (CK) catalyzed phosphorus fluxes between phosphocreatine (PCr) and ATP and changes in reactant concentrations were measured using [31P] nuclear magnetic resonance spectroscopy ([31P]NMR) before and during pentylenetetrazole-induced seizures in 7 and 21 day old rats." | 3.69 | Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats. ( Holtzman, D; Jensen, F; Khait, I; Meyers, R, 1997) |
| " This compound blocked bicuculline induced seizures, did not elevate seizure threshold following iv infusion of metrazole, and blocked influx of Ca2+ ions into cerebellar granule cells induced by K+ or veratridine." | 3.69 | Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents. ( Almond, HR; Carmosin, RJ; Carson, JR; Pitis, PM; Stables, JP; Swinyard, EA; Vaught, JL; White, HS; Wolf, HH, 1997) |
| " Initial screening in mice dosed intraperitoneally and rats dosed orally indicated that 4-AEPB is active against maximal electroshock-induced seizures (MES), but does not protect animals against subcutaneous pentylenetetrazole (sc Ptz)-induced seizures." | 3.69 | Anticonvulsant and neurotoxicological properties of 4-amino-N-(2-ethylphenyl)benzamide, a potent ameltolide analogue. ( Bourhim, M; Diouf, O; Lambert, DM; Poupaert, JH; Stables, JP; Vamecq, J, 1997) |
| " At subeffective doses, beta-eudesmol and phenytoin showed additive effect in preventing electroshock seizures." | 3.69 | Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices. ( Chang, CC; Chiou, LC; Ling, JY, 1997) |
| " also induced seizures after treatment with a subthreshold dose of pentylenetetrazole (40 mg/kg i." | 3.69 | Comparative in vivo and in vitro studies with the potent GABAB receptor antagonist, CGP 56999A. ( Badran, S; Olpe, HR; Schmutz, M, 1997) |
| "The anticonvulsant topiramate is effective in laboratory animals against maximal electroshock seizures, amygdala kindling, and spike-wave discharges and has demonstrated efficacy in humans for the treatment of complex partial seizures." | 3.69 | Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. ( Brown, SD; Skeen, GA; White, HS; Wolf, HH; Woodhead, JH, 1997) |
| "The effects of 3,5,3'-triiodothyronine (T3) levels on threshold, latency and duration of pentylenetetrazole-induced seizures were tested in rats treated with thyroxine (300 micrograms/kg." | 3.69 | T3 deficiency prolongs convulsions induced by acute pentylenetetrazole. ( Chambert, G; Pacheco-Rosado, J; Quevedo-Corona, L; Zamudio-Hernández, SR, 1997) |
| "The effects of prostaglandin E-analogue misoprostol on the susceptibility to pentilenetetrazol (PTZ)-induced seizures were examined in mice." | 3.69 | Effects of misoprostol on pentylenetetrazol-induced seizures in mice. ( Figueiredo, EG; Medeiros F das, C; Medeiros, MA; Rao, VS, 1997) |
| "The action of progabide against motor seizures elicited by pentylenetetrazol was studied in 7-, 12-, 18-, 25-day-old and adult rats." | 3.69 | Anticonvulsant effect of progabide in rats during ontogenesis. ( Kozuchová, A; Mares, P; Stanková, L, 1997) |
| " The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats." | 3.69 | Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| " GYKI 52466 was also protective against seizures and lethality induced by 4-aminopyridine, kainate and AMPA, but not by NMDA, whereas NBQX was ineffective in these chemoconvulsant tests." | 3.68 | Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. ( Donevan, SD; Rogawski, MA; Yamaguchi, S, 1993) |
| "6 mg/kg pentylenetetrazole and exhibited an increase in susceptibility to clonic seizures." | 3.68 | State-dependent stimulus control: cueing attributes of ethanol "hangover" in rats. ( Gauvin, DV; Goulden, KL; Holloway, FA, 1993) |
| " 1,3-Dihydro-1,3-dimethyl-5-phenyl-2H-pyrido[3,2-e]-1,4-diazepin-2- one (13) inhibited sc bicuculline and sc picrotoxin induced seizures, but it did not inhibit in vitro benzodiazepine binding which suggests it may act by a different mechanism of action." | 3.68 | Synthesis and anticonvulsant activity of 1,3-dihydro-5-phenyl-2H-pyrido[3,2-e]-1,4-diazepin-2-ones. ( Fiakpui, CY; Knaus, EE, 1993) |
| "We have studied the effect of Pentylenetetrazole (PTZ)-induced seizures on the state of phosphorylation of microtubule-associated protein 2 (MAP-2) from rat hippocampus." | 3.68 | Rapid dephosphorylation of microtubule-associated protein 2 in the rat brain hippocampus after pentylenetetrazole-induced seizures. ( Avila, J; Díez-Guerra, FJ, 1993) |
| "D-Cycloserine has been shown to exert anticonvulsant activity in maximal electroshock seizures." | 3.68 | The anticonvulsant activity of D-cycloserine is specific for tonic convulsions. ( Peterson, SL; Schwade, ND, 1993) |
| " None of the quinolones tested including BMY-40062 modified the seizures induced by bicuculline, a specific GABA A antagonist." | 3.68 | Pharmacological properties of a new fluoroquinolone on the central nervous system in rodents. ( Guiol, C; Ledoussal, C; Surgé, JM, 1993) |
| "The influence of flumazenil on seizures induced by pentylenetetrazol (PTZ) was studied in rats aged 7, 12, 18, 25, and 90 days." | 3.68 | Anticonvulsant activity of flumazenil in rats during ontogenetic development. ( Kubová, H; Mares, P; Rathouská, J; Vorlícek, J, 1993) |
| " In flurothyl-induced seizures, CA deficient mice displayed longer latencies to the onset of both clonic and tonic-clonic seizures." | 3.68 | Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice. ( Cammer, W; Moshé, SL; Velísek, L; Xu, SG, 1993) |
| "The action of ethosuximide (125 or 250 mg/kg, IP) against picrotoxin-induced seizures (3-6 mg/kg, IP) was assessed in rats 12, 18, 25, and 90 days old." | 3.68 | Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. ( Mares, P; Micianiková, D; Rokyta, R; Velísek, L; Velísková, J, 1993) |
| "Immunohistological and in situ hybridization techniques were used to study the influence of kainic acid-induced seizures and of pentylenetetrazol kindling on neurokinin B immunoreactivity and neurokinin B mRNA in the rat hippocampus." | 3.68 | Limbic seizures cause pronounced changes in the expression of neurokinin B in the hippocampus of the rat. ( Bellmann, R; Krause, JE; Marksteiner, J; Ortler, M; Sperk, G; Wahler, R, 1992) |
| " In the strychnine seizure test (mice), ralitoline (5 and 10 mg/kg) prolonged the latency of tonic seizures as well as the survival time." | 3.68 | Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models. ( Bodewei, R; Fischer, W; Satzinger, G, 1992) |
| "The influence of sustained epileptic seizures evoked by intraperitoneal injection of kainic acid on the gene expression of the neuropeptides somatostatin and neuropeptide Y and on the damage of neurons containing these peptides was studied in the rat brain." | 3.68 | Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat. ( Bellmann, R; Gruber, B; Mahata, M; Marksteiner, J; Ortler, M; Sperk, G, 1992) |
| " (ED50 and ED85 doses, respectively, for inhibiting pentylenetetrazole-induced tonic seizures)." | 3.68 | The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. ( Fink-Jensen, A; Hansen, L; Judge, ME; Nielsen, PG; Suzdak, PD; Swedberg, MD, 1992) |
| " In vivo, NNC-711 was a potent anticonvulsant compound against rodent seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) (ED50 (clonic) = 1." | 3.68 | NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. ( Andersen, KE; Frederiksen, K; Knutsen, LJ; Nielsen, EB; Suzdak, PD; Sørensen, PO, 1992) |
| "The anticonvulsant actions of lamotrigine and phenytoin against pentylenetetrazol-induced seizures were compared in laboratory rats during ontogenesis." | 3.68 | Anticonvulsant action of lamotrigine during ontogenesis in rats. ( Kubová, H; Mares, P; Stanková, L, 1992) |
| "Tolerance to the anticonvulsant effects of clobazam has been studied in three murine models of epilepsy: pentylenetetrazole- and N-methyl-D,L-aspartic acid-induced seizures and audiogenic-induced seizures in the DBA/2 strain." | 3.68 | Tolerance to the anticonvulsant effects of clobazam in mice. ( Pleuvry, BJ; Wildin, JD, 1992) |
| "The anticonvulsant effects and duration of protective action of midazolam against Metrazol induced seizures were studied in 528 rats aged 7,12,18,25 and 90 days." | 3.68 | The effect of ontogenetic development on the anticonvulsant activity of midazolam. ( Kubová, H; Mares, P, 1992) |
| "This study determined the effects of bilateral discrete partial lesions of cholinergic neurons of the laterodorsal tegmental nucleus (LDTg) of the pontomesencephalic tegmentum on seizures induced by intravenous pentylenetetrazol (PTZ)." | 3.68 | Effects of selective toxic lesions of cholinergic neurons of the laterodorsal tegmental nucleus on experimental seizures. ( Bardgett, ME; Gray, BC; Miller, JW, 1992) |
| "The protective effects of subanesthetic and anesthetic doses of propofol and thiopentone against pentylenetetrazol (PTZ)- induced seizures were studied in the rat." | 3.68 | The effect of propofol and thiopentone on pentylenetetrazol seizure threshold in the rat. ( al-Hader, AA; Hasan, MM; Hasan, ZA; Takrouri, MS, 1992) |
| " The effects of the octapeptide angiotensin II (AT II) on some types of behaviour [threshold of seizures induced by timed intravenous infusion of pentylenetetrazol (PTZ), exploratory behaviour: ambulation, rearing and head-dips on a hole-board, and passive avoidance performance--step-through paradigm] were studied following repeated systemic administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to mice (30 mg/kg, i." | 3.68 | Behavioural effects of angiotensin II in the mouse following MPTP administration. ( Georgiev, V; Kambourova, T, 1991) |
| "The anticonvulsant effects of felbamate alone or in combination with diazepam were investigated against maximal electroshock-, pentylenetetrazol-, isoniazid- and bicuculline-induced seizures in mice." | 3.68 | Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1991) |
| " The anticonvulsant effects of subanaesthetic doses of propofol and thiopentone against PTZ-induced seizures and mortality were examined in the rat." | 3.68 | A comparison of the anticonvulsant effects of propofol and thiopentone against pentylenetetrazol-induced convulsions in the rat. ( al-Hader, A; Hasan, M; Hasan, Z; Takrouri, M, 1991) |
| " Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced seizures in mice is related to the elevation of whole brain GABA concentrations: The mentioned doses of MDL 72483 which cause a decrease of GABA-T activity by 50%, produce within 5 h after dosing an increase of GABA concentration by about 3 mumol." | 3.68 | (4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor. ( Casara, P; Knödgen, B; Sarhan, S; Seiler, N, 1991) |
| "Appearances of pentetrazole-, picrotoxin- and strychnine-induced convulsive seizures in taurine-deficient mice produced by treatment with guanidinoethyl sulfonate (GES), a taurine transport antagonist, were investigated." | 3.68 | [Drug-induced seizures in taurine-deficient mice]. ( Araki, H; Sano, M; Shimada, C; Tanaka, S, 1991) |
| " The anticonvulsant activity of tiagabine was evaluated against seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), pentylenetetrazol, bicuculline, maximal electrostimulation (MES), or high intensity sound." | 3.68 | Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. ( Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD, 1991) |
| "The anticonvulsant actions of the adenosine receptor agonists, 1-phenylisopropyladenosine, 2-chloroadenosine and cyclohexyl-adenosine, against DMCM (methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate)-induced seizures in mice were studied with an infusion technique." | 3.68 | Selective protection by adenosine receptor agonists against DMCM-induced seizures. ( Petersen, EN, 1991) |
| "This study determined the effects of discrete microinjections of GABA agonists in the cholinergic nuclei of the pontomesencephalic tegmentum on spontaneous behavior and seizures induced by intravenous pentylenetetrazol, bicuculline or strychnine, in the rat." | 3.68 | The role of the laterodorsal tegmental nucleus of the rat in experimental seizures. ( Bardgett, ME; Gray, BC; Miller, JW, 1991) |
| " The compounds were screened in mice for their ability to antagonize maximal electroshock-, pentylenetetrazole- and bicuculline-induced seizures; sedative effects were evaluated by a study of the spontaneous motor activity." | 3.68 | Synthesis and pharmacological evaluation of 6,8-diaryl 1,2,4-triazolo [4,3,-b] and 1,2,3,4,-tetrazolo [1,5-b] pyridazines. ( Bastide, J; Bastide, P; Coudert, P; Couquelet, JM; Rubat, C; Tronche, P, 1990) |
| "This study evaluates the glycine potentiation of anticonvulsant drugs in subcutaneous pentylenetetrazol seizures in rats." | 3.68 | Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats. ( Peterson, SL, 1991) |
| "The present study was to examine the effect on the blood-brain barrier function of a rapid blood pressure elevation and the duration of this pressure during bicuculline and pentylenetetrazol-induced seizures." | 3.68 | The effect of acute hypertension on blood-brain barrier permeability to albumin during experimentally induced epileptic seizures. ( Kaya, M; Oztaş, B, 1991) |
| "In gerbils pentylenetetrazole- or handling-induced seizures were accompanied by cerebral formation of small amounts of cysteinyl-leukotrienes (LT) but large amounts of prostaglandin (PG) F2 alpha." | 3.68 | On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures. ( Simmet, T; Tippler, B, 1991) |
| " The parameters studies included body weight, pentobarbitone (50 mg/kg) sleeping time, chlorpromazine (6 mg/kg) induced motor incoordination and convulsions induced by leptazol (100 mg/kg) and electrical stimulation (18 mA for 0." | 3.68 | Effect of subacute insecticide exposure on body weight, drug responses & electrical convulsions in mice. ( Agarwal, AK; Sankaranarayanan, A; Sharma, PL, 1990) |
| " Its protective efficacy against theophylline-induced seizures was determined in this investigation in view of the limited effectiveness of presently available anticonvulsants against this manifestation of serious theophylline intoxication." | 3.68 | Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "In order to determine the gamma-L-glutamyl-L-aspartate (gamma-LGLA) site of action in excitatory amino acids (EAA) systems, we studied the gamma-LGLA anticonvulsant activity against seizures induced in mice by pentylenetetrazol, picrotoxin and EAA agonists." | 3.68 | NMDA antagonist properties of gamma-L-glutamyl-L-aspartate demonstrated on chemically induced seizures in mice. ( De Barry, J; Mathis, C; Ungerer, A, 1990) |
| ") were studied on model motor seizures induced by strychnine, bicuculline, 3-mercaptopropionic acid and metrazol in male laboratory rats (Wistar strain)." | 3.68 | Anticonvulsant effects of clonazepam on chemically induced convulsions. ( Bohuslav, T; Kubová, H; Mares, P, 1990) |
| " Effect of quinine on electroshock and pentylenetetrazol (leptazol)-induced seizures was investigated in mice." | 3.68 | Effect of quinine on electroshock and pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Sokomba, E; Wambebe, C, 1990) |
| "Sodium phenobarbitone (20 and 70 mg/kg) had a significant anticonvulsant action against pentylenetetrazole-induced seizures, which persisted for 21 days of treatment." | 3.68 | Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal. ( File, SE; Wilks, LJ, 1990) |
| "The effects of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole were studied in mice." | 3.68 | Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice. ( Kaneto, H; Miwa, T; Nakamura, J; Sasaki, H; Shibasaki, J, 1990) |
| " PK 11195 (up to 120 mg kg-1) was ineffective at counteracting seizures caused by the convulsant benzodiazepine Ro 5-3663, although this dose did increase the latency to seize after injection with pentylenetetrazole." | 3.67 | Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance. ( File, SE, 1984) |
| "Fumitremorgin A (FTA), a neurotropic mycotoxin induced dose-dependent abnormal behaviors, including tremor, clonic convulsion, kangaroo posture and tonic extensor convulsion in the mouse." | 3.67 | Abnormal behavioral effects elicited by a neurotropic mycotoxin, fumitremorgin A in mice. ( Kikkawa, K; Suzuki, S; Yamazaki, M, 1984) |
| "The potencies of seven benzodiazepines (BDZs) were established by three tests: inhibition of [3H]flunitrazepam receptor binding, inhibition of [3H]adenosine uptake, and prevention of pentylenetetrazol-induced seizures in mice." | 3.67 | Benzodiazepine inhibition of flunitrazepam receptor binding, adenosine uptake, and pentylenetetrazol-induced seizures in mice. ( Chweh, AY; Swinyard, EA; Wolf, HH, 1984) |
| "Injections of 5,7-dihydroxytryptamine (5,7-DHT) in the rat ventromedial tegmentum, which depleted forebrain serotonin, and of 6-hydroxydopamine in the dorsal noradrenergic bundle, which caused a marked reduction of forebrain noradrenaline, intensified pentylenetetrazol (PTZ)-induced seizures." | 3.67 | Evidence that the dorsal raphe area is involved in the effect of clonidine against pentylenetetrazole-induced seizures in rats. ( Bendotti, C; Lazarova, M; Samanin, R, 1984) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 3.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "The threshold for pentylenetetrazol (PTZ)-induced clonic seizures is below control levels 15 min after administration of apomorphine (APO) but above them 60 min after APO administration." | 3.67 | Effects of ascorbate on a dopaminergic response: apomorphine-induced modification of pentylenetetrazol-induced seizures in mice. ( Goldman, CP; Riffee, WH; Wilcox, RE; Young, RK, 1984) |
| "The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures." | 3.67 | Glycine potentiates the action of some anticonvulsant drugs in some seizure models. ( Lajtha, A; Toth, E, 1984) |
| "The purposes of this investigation were to determine the effect of pregnancy on the susceptibility of female rats to experimentally induced seizures and on the relationship between serum phenytoin concentration and antiseizure activity." | 3.67 | Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats. ( Chou, RC; Levy, G, 1984) |
| "The seizure sensitive Mongolian gerbil, a genetic model of epilepsy, has been used to investigate the effects of prior spontaneous seizures on the threshold for pentylenetetrazole (PTZ) and maximum electroshock (MES) induced convulsions." | 3.67 | The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil. ( Lee, RJ; Lomax, P, 1984) |
| " Picrotoxin and pentylenetrazol-induced seizures were also blocked with corresponding ED50 values for clonic convulsions of 224." | 3.67 | Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate. ( Crider, AM; Hinko, CN; Seibert, K, 1984) |
| " Aminolaevulinic acid was administered by intraperitoneal or subcutaneous injection to mice in doses up to 1000 mg/kg and effects on nociception (hot-plate and abdominal constriction tests), CNS excitability (pentobarbitone sleep-time and pentylenetetrazole-induced seizures), motor co-ordination and grip (rotating rod test) were studied." | 3.67 | Neuropharmacology of delta-aminolaevulinic acid--I. Effect of acute administration in rodents. ( Edwards, SR; Reynoldson, JA; Shanley, BC, 1984) |
| "The goal of this study was to test the hypothesis that phentolamine and propranolol premedication would affect tonus differently than clonus in pentylenetetrazol (PTZ)-induced tonic-clonic seizures in dogs." | 3.67 | Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs. ( Cunningham, JG; Stephenson, RB, 1984) |
| " The compounds were tested in mice against seizures induced by electroshock and pentylenetetrazole ( metrazole ) and in the rotorod assay for neurologic deficit." | 3.67 | Anticonvulsant activity of some 4-aminobenzamides. ( Clark, CR; Dockens, RC; Norris, GN; Ravis, WR; Sansom, RT; Wells, MJ, 1984) |
| "The effects of chemically and electrically-evoked seizures on [3H]nitrendipine binding to voltage-dependent calcium channels in mouse brain were determined 30 and 60 min following the initiation of convulsions." | 3.67 | The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain. ( Bolger, GT; Weissman, BA, 1987) |
| " In the present investigations the action of the calcium antagonist verapamil on generalized tonic-clonic seizures was studied." | 3.67 | Suppression of recurrent generalized tonic-clonic seizure discharges by intraventricular perfusion of a calcium antagonist. ( Speckmann, EJ; Walden, J, 1988) |
| "Concentrations of plasma amino acids and brain monoamines as well as pentylenetetrazol-induced seizures were monitored in CD-1 mice treated with aspartame in acute oral doses from 0 to 2500 mg/kg." | 3.67 | Aspartame fails to facilitate pentylenetetrazol-induced convulsions in CD-1 mice. ( Bettendorf, AF; Burger, RL; Dailey, JW; Jobe, PC; Lasley, SM; Mishra, PK, 1989) |
| "Changes in immunoreactivity of calcitonin gene-related peptide (CGRP) were investigated in the brains of rats subsequently to seizures induced by intraperitoneal injection of kainic acid (10 mg/kg, i." | 3.67 | Pronounced increases in brain levels of calcitonin gene-related peptide after kainic acid induced seizures. ( Humpel, C; Marksteiner, J; Saria, A; Sperk, G, 1989) |
| "An anticonvulsant action of ketamine, a noncompetitive NMDA receptor antagonist (1-40 mg/kg IP), on the metrazol-induced seizures was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.67 | Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. ( Blanková-Vanková, S; Mares, P; Mikolásová, R; Velísek, L, 1989) |
| "The anticonvulsant activity of two competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor, 2-amino-7-phosphonoheptanoic acid (APH) and 3-[2-carboxypiperazin-4-yl]-propyl-1-phosphonate (CPP), and two non-competitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), were compared in 4 models of induced seizures in mice." | 3.67 | A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor. ( Arnolde, SM; Nevins, ME, 1989) |
| " We determined the role of gamma-aminobutyric acid (GABA)ergic activity of the SN and the target sites of SN efferents, the pedunculopontine nucleus (PPN) and superior colliculus (SC), in pentylenetetrazol-induced seizures in rats." | 3.67 | The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures. ( Nagaya, H; Negishi, N; Okada, R, 1989) |
| "The effects of the diterpene sclareol glycol (SG) of the labdane family on convulsive seizures induced by pentylenetetrazole (PTZ), picrotoxin and bicuculline in mice were studied." | 3.67 | Effects of the diterpene sclareol glycol on convulsive seizures. ( Georgieva, J, 1989) |
| " The compounds which inhibited the electroshock-induced seizures (MES) in mice, namely N-[4-(beta-phenylethyl)phenacyl]formamide (VII) and N-[2-[4-(beta-phenylethyl)phenyl]-2-hydroxyethyl]formamide (IX), proved active also as inhibitors of the pentylenetetrazole-induced tonic seizures." | 3.67 | Synthesis and anticonvulsant evaluation of 1,2-diphenylethane derivatives, potential metabolites of denzimol. ( Catto, A; Leonardi, A; Nardi, D; Rossi, A; Testa, R, 1989) |
| "L-lysine, an essential amino acid for man and animals, and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice." | 3.67 | Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures. ( Chang, YF; Chen, JS; Hargest, V, 1988) |
| "In mice, the influence of small (analgesic range) doses of morphine, fentanyl, meperidine and pentazocine on the thresholds for seizures induced by electroshock and pentetrazole was studied." | 3.67 | Effect of morphine and morphine-like analgesics on susceptibility to seizures in mice. ( Czuczwar, SJ; Frey, HH, 1986) |
| "The rate of development of tolerance to the benzodiazepines clorazepate and clonazepam against pentetrazole-induced seizures in mice was compared." | 3.67 | Tolerance to the anticonvulsant effect of clorazepate and clonazepam in mice. ( Frey, HH; Kurudi, D; Scherkl, R, 1988) |
| " RO 15-3505 induced seizures in mice treated with a subconvulsant dose of pentylenetetrazole, the most efficient doses being 3 and 6 mg/kg." | 3.67 | The benzodiazepine receptor inverse agonists beta-CCM and RO 15-3505 both reverse the anxiolytic effects of ethanol in mice. ( Belzung, C; Misslin, R; Vogel, E, 1988) |
| " alpha 2-Adrenoceptor antagonists were proconvulsant; dose dependently reducing the threshold for pentylenetetrazol- or bicuculline-induced tonic seizures." | 3.67 | A proconvulsant action of selective alpha 2-adrenoceptor antagonists. ( Fletcher, A; Forster, EA, 1988) |
| ") to mice, had only a marginal protective effect against seizures induced 1 hr later by 3-mercaptopropionic acid (MPA)." | 3.67 | Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor. ( Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N, 1985) |
| "The anticonvulsive action of diazepam, carbamazepine, sodium valproate and their combinations with pyridoxal-5-phosphate, nicotinamide, and alpha-tocopherol were investigated in acute experiments on mice with corazole-induced seizures." | 3.67 | [Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity]. ( Kryzhanovskiĭ, GN; Shandra, AA, 1985) |
| "The effects of cinromide on two types of metrazol-induced seizures were studied in 236 male rats aged 7, 12, 18, 25 and 90 days." | 3.67 | Influence of cinromide on metrazol--induced seizures during ontogenesis in rats. ( Bernásková, K; Mares, P; Rokyta, R, 1988) |
| "The effects of acute exposure to acrylonitrile (ACN), 10, 20, or 40 mg/kg by gavage, on the ability of metrazol (MTZ) to induce seizures was studied in adult, male Sprague-Dawley rats." | 3.67 | Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat. ( Adams, PM; Ahmed, AE; Fanini, D; Sadagopa Ramanujam, VM; Trieff, NM, 1985) |
| "Lysine and its metabolic intermediates were studied for their effect on pentylenetetrazol (PTZ)-induced seizures in mice." | 3.67 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "Repeated administration of the beta-carboline benzodiazepine receptor ligand FG 7142 produces sensitization to its effects so that full seizures develop (chemical kindling); initially it is only pro-convulsant." | 3.67 | The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142. ( Little, HJ; Nutt, DJ; Taylor, SC, 1986) |
| "The effects of various metabolically-stable analogs of adenosine on the threshold for seizures in rats was determined by measuring the dose of pentylenetetrazol (PTZ), infused through a tail vein, required to elicit a myoclonic jerk." | 3.67 | Purinergic modulation of the seizure threshold for pentylenetetrazol in the rat. ( Murray, TF; Schultz, CS; Sylvester, D; Szot, P, 1985) |
| "2-Amino-6-trifluoromethoxy benzothiazole (PK 26124) prevented convulsions induced in rodents by maximal electroshock, inhibitors of the synthesis of gamma-aminobutyric acid (GABA) and ouabain, but was inactive against seizures provoked by GABA antagonists, unlike diazepam, chlordiazepoxide, phenobarbital and valproic acid." | 3.67 | 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties. ( Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A, 1985) |
| " ED50 value of diazepam was established against pentylenetetrazole-induced seizures in rats." | 3.67 | Apparent pA2 estimation of benzodiazepine receptor antagonists. ( Kulkarni, SK; Kunchandy, J, 1986) |
| " The present study aimed at investigating the effects of microgram doses of this benzodiazepine on i) the threshold doses of either pentylenetetrazole, picrotoxin or bicuculline required to induce seizures in mice and ii) the suppression of lever pressing for food induced by the delivery of one electric footshock every ten presses in rats pretreated or not with isoniazid (64 mg/kg IP)." | 3.67 | Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents. ( Laporte, AM; Soubrié, P; Thiébot, MH, 1987) |
| "GDEE, a specific but low-potency antagonist of the quisqualate or 'Type 2' excitatory amino acid receptor, blocks seizures induced by homocysteine and quisqualic acid." | 3.67 | Anticonvulsant activity of deaminated analogues of glutamic acid diethyl ester (GDEE). ( Braun, DE; Freed, WJ, 1988) |
| "The relationship between the focus of cobalt seizures in the cerebral cortex and neuron loss in the hippocampus, as well as the CD50 of pentylenetetrazol was examined in rats." | 3.67 | Damage of hippocampal neurons caused by cobalt focus in the cerebral cortex of rats. ( Hosoya, E; Iizuka, S; Ishige, A; Sediguchi, K; Sugaya, E; Sugimoto, A; Yuzurihara, M, 1988) |
| "This study investigated the effects of acute and chronic caffeine treatment on behavior in the social interaction, holeboard and home-cage aggression tests and on proconvulsant actions with pentylenetetrazol." | 3.67 | Behavioral effects of acute and chronic administration of caffeine in the rat. ( Baldwin, HA; File, SE; Johnston, AL; Wilks, LJ, 1988) |
| "The anticonvulsant activity of avermectin B (AVM) was studied after systemic administration in DBA/2 mice (seizures induced by sound) and rats (seizures induced by pentylenetetrazol, cephazolin and maximal electroshock test)." | 3.67 | Anticonvulsant effects of avermectin in DBA/2 mice and rat. ( Ammendola, D; De Sarro, A; De Sarro, GB; Germanà, G; Naccari, F; Rotiroti, D, 1988) |
| "An association has recently been proposed between the incidence of seizures and prolonged consumption of the phenylalanine-containing artificial sweetener, aspartame." | 3.67 | Administration of aspartame potentiates pentylenetetrazole- and fluorothyl-induced seizures in mice. ( Maher, TJ; Pinto, JM, 1988) |
| " The GABA-T inhibitor dose-dependently protected mice against isoniazid-induced seizures, simultaneously causing an increase in brain GABA concentrations." | 3.67 | Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice. ( Bernasconi, R; Christen, P; Hafner, T; Klein, M; Martin, P; Portet, C; Schmutz, M, 1988) |
| " The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively." | 3.67 | A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties. ( Balm, M; Coyle, JT; Markl, A; Zaczek, R, 1986) |
| "Nimodipine, a dihydropyridine that interacts with a Ca++ channel-associated binding site, when delivered (30 to 150 micrograms/kg) intra-arterially (ia) to enflurane-anesthetized cats, produced a dose-dependent suppression of seizures evoked by pentylenetetrazol." | 3.67 | Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats. ( Anderson, RE; Ots, ME; Sundt, TM; Yaksh, TL, 1987) |
| "Continuous release of diazepam from subcutaneously implanted silastic capsules provided significant protection against pentylenetetrazol seizures in rats for up to 3 weeks." | 3.67 | Tolerance to anti-pentylenetetrazol effects following chronic diazepam. ( Gallager, DW; Gonsalves, SF, 1986) |
| " The compounds were tested in mice against seizures induced by maximal electroshock (MES) and pentylenetetrazole and in the rotorod assay for neurologic deficit." | 3.67 | Anticonvulsant activity of 2- and 3-aminobenzanilides. ( Clark, CR; Lin, CM; Sansom, RT, 1986) |
| "Blood-brain barrier (BBB) permeability to macromolecules was assessed during seizures induced by pentylenetetrazole, bicuculline, methoxypyridoxine, methionine sulfoximine, and kainic acid." | 3.67 | Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures. ( Goping, G; Klatzo, I; Nitsch, C, 1986) |
| "The relative ability of phenytoin, ethosuximide and valproate to prevent minimal (clonic) threshold, maximal (tonic extension of the hindlimbs) threshold and supramaximal (tonic extension of the hindlimbs) seizures elicited by electrical and chemical (Metrazol, bicuculline, and picrotoxin) stimulation was determined." | 3.67 | Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate. ( Piredda, SG; Swinyard, EA; Woodhead, JH, 1985) |
| " The compounds were screened in mice for their ability to antagonize maximal electroshock- and bicuculline-induced seizures; neurotoxicity was evaluated in the rotorod test." | 3.67 | Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. ( Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J, 1986) |
| " We report herein the influence of nimodipine, a selective central nervous system calcium channel blocker, in 60 rabbits with seizures that had been induced through ischemia, postischemia reperfusion, pentylenetetrazol, and bicuculline." | 3.67 | Selective central nervous system calcium channel blockers--a new class of anticonvulsant agents. ( Anderson, RE; Meyer, FB; Sharbrough, FW; Sundt, TM, 1986) |
| "The ability of betaine to block homocysteine, pentylenetetrazol, and electroshock induced seizures in mice has previously been observed." | 3.67 | Effects of betaine on seizures in the rat. ( Freed, WJ; Ghoz, EH, 1985) |
| "The effect of inhibiting endogenous brain thromboxane (TXB2) on pentylenetetrazole-induced seizures was studied using the thromboxane synthetase inhibitors OKY-1581 (20 mg/kg) and UK 38,485 (50 mg/kg)." | 3.67 | The effect of inhibiting brain thromboxane biosynthesis on pentylenetetrazole-induced seizure threshold. ( Centra, M; Lysz, TW; McGinley, S, 1985) |
| " The compounds were tested in mice against seizures induced by electroshock and metrazole (pentylenetetrazole) and in the rotorod assay for neurologic deficit." | 3.67 | Anticonvulsant activity of some 4-aminobenzanilides. ( Clark, CR; Lin, CM; Norris, GN; Sansom, RT, 1985) |
| "The anticonvulsant efficacy of the GABAmimetic drugs cetyl GABA, progabide and THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-ol) was studied against minor (myoclonic) and major (generalized tonic-clonic) seizures in gerbils as well as against maximal electroshock and s." | 3.67 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "Acute administration of phenytoin (40 and 75 mg/kg) was unable to counteract seizures induced by pentylenetetrazole and even prolonged them in some cases." | 3.67 | Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse. ( File, SE; Pellow, S; Wilks, L, 1985) |
| "The antagonism of various components of maximal metrazol-seizures and the induction of ataxia have been studied in mice and rats by comparing Denzimol to 10 standard antiepileptic drugs." | 3.67 | Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and mice. ( Ibba, M; Testa, R; Vanasia, A, 1985) |
| " The onset of generalized seizures induced by isoniazid (800 mg/kg) or by thiosemicarbazide (64 mg/kg) i." | 3.66 | Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats. ( Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH, 1980) |
| "The combined use of di-n-propylacetate with phenazepam, diazepam, phenobarbital or phenytoin was shown to be followed by reciprocal potentiation of the anticonvulsant activity of the drugs in a variety of experimental epileptic seizures in mice according to the tests of shock and antagonism with corasole and thiosemicarbazide." | 3.66 | [Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin]. ( Kosoĭ, MIu, 1981) |
| "The anticonvulsant effects of clonazepam, nitrazepam and chlordiazepoxide alone, or combined with diphenylhydantoin, were studied on pentylenetetrazol- and bicuculline-induced seizures." | 3.66 | Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, L, 1982) |
| "70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures." | 3.66 | Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures. ( Anisman, H; Hill, DA; Ings, R; Pappas, BA, 1983) |
| "In adult male albino BALB/c mice inosine (INS, 100 and 200 micrograms, intraventricularly) prolonged the latency of pentylenetetrazol (PTZ) seizures while nicotinamide (NAM) exerted an opposite effect." | 3.66 | Dissimilar effects of nicotinamide and inosine, putative endogenous ligands of the benzodiazepine receptors, on pentylenetetrazol seizures in four strains of mice. ( Lapin, IP, 1980) |
| "Nicotinamide (NAM, 1000 mg/kg), inosine (INS, 1000 mg/kg), hypoxanthine (HXT, 500 mg/kg), putative endogenous ligands of the benzodiazepine receptor, and nicotinic acid (NA, 500 mg/kg) diminished DL-kynurenine-(DL-K, 50 micrograms ICV) induced seizures in C57BL/6 adult male mice and only prolonged the latency of pentylenetetrazol (PTZ, 500 micrograms iCV) seizures." | 3.66 | Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures. ( Lapin, IP, 1981) |
| " None of the drugs tested had any consistent effect on the regulation of cyclic GMP levels in brain during seizures." | 3.66 | Relationships between norepinephrine and cyclic nucleotides in brain and seizure activity. ( Ferrendelli, JA; Gross, RA, 1982) |
| "10 mg/kg yohimbine significantly reduced the latency to the first convulsion of rats treated with 90 mg/kg pentylenetetrazol (PTZ) and markedly increased the number of animals showing generalized strong clonic seizures and dying within 1 h." | 3.66 | Potentiation by yohimbine of pentylenetetrazol-induced seizures in rats: role of alpha 2 adrenergic receptors. ( Lazarova, M; Samanin, R, 1983) |
| "The dose response curves of picrotoxin-induced seizures and pentylenetetrazol-induced seizures were shifted to the right by the benzodiazepine (BZ) receptor agonist lorazepam, and to the left by the inverse agonists, DMCM, ZK 90886, FG 7142 and CGS 8216." | 3.66 | Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures. ( Jensen, LH; Petersen, EN, 1983) |
| "5,7-Dihydroxytryptamine (5,7-DHT) injections which caused selective depletion of serotonin in the forebrain enhanced the seizures caused by pentylenetetrazol (PTZ 90 mg/kg s." | 3.66 | Studies on the role of serotonin in different regions of the rat central nervous system on pentylenetetrazol-induced seizures and the effect of di-n-propylacetate. ( Bendotti, C; Lazarova, M; Samanin, R, 1983) |
| "The effect of valproic acid and 10 close analogues (7 branched and 3 non-branched) were studied on the content of gamma-aminobutyric acid (GABA) in brain and on seizures induced by pentylenetetrazol (PTZ) in mice." | 3.66 | The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice. ( Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J, 1983) |
| "The effect of chronic para-chlorphenylalanine (PCPA) treatment was investigated in two different seizure models: the pentylenetetrazole (PTX) seizure model in rats and the kindled seizures from rabbit amygdala." | 3.66 | Effect of chronic para-chlorophenylalanine treatment on convulsive-seizure reactions. ( Kacz, D; Lazarova, M; Petkov, V; Roussinov, K; Stach, R; Yanev, S, 1981) |
| " Although none of the compounds tested showed significant activity against convulsions induced by pentylenetetrazole (PTZ), some showed significant activity against maximal electroshock seizures in mice." | 3.66 | Synthesis of aminomethyl-substituted cyclic imide derivatives for evaluation as anticonvulsants. ( Curley, RW; Stratford, ES, 1983) |
| "In several species, larger doses of systemically-administered morphine induce seizures while smaller doses potentiate chemically-induced convulsions." | 3.66 | Effect of morphine pretreatment on pentylenetetrazol-induced seizures in the rat. ( Wallenstein, M, 1983) |
| "The development of tolerance to the protective effects of diazepam (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) were studied in 3 strains of mice." | 3.66 | Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam. ( File, SE, 1983) |
| "Neurotoxicity and protection against maximal electroshock and Metrazol seizures from primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA) were determined in mice for each drug separately and expressed in terms of brain concentrations." | 3.66 | Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice. ( Bourgeois, BF; Dodson, WE; Ferrendelli, JA, 1983) |
| "Neurotoxicity and protection against maximal electroshock (MES) and pentylenetrazol (Metrazol) seizures were determined in mice for various combinations of primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA)." | 3.66 | Primidone, phenobarbital, and PEMA: II. Seizure protection, neurotoxicity, and therapeutic index of varying combinations in mice. ( Bourgeois, BF; Dodson, WE; Ferrendelli, JA, 1983) |
| "The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice." | 3.66 | Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice. ( Bruni, J; Hammond, EJ; Wilder, BJ, 1981) |
| " Catalepsy and analgesia were found in varying degrees after maximal electroshock (MES), metrazol, picrotoxin, and Ro 5-3663 activated seizures." | 3.66 | Convulsant-specific architecture of the postictal behavior syndrome in the rat. ( Kofman, O; Mintz, M; Myslobodsky, M, 1981) |
| "Based on previous work examining the effects of dextroamphetamine on pentylenetetrazol (PTZ)-induced clonic seizure threshold, the objective of the present study was to determine the effects of two other dopamine agonists, apomorphine (AP) and piribedil, on PTZ seizures." | 3.66 | Effects of apomorphine and piribedil on pentylenetetrazol-induced seizures in mice. ( Goldman, CP; Riffee, WH; Smith, RV; Wilcox, RE, 1981) |
| "5 mg/kg clonidine significantly increased the latency to the first convulsion and reduced tonic seizures and mortality caused by pentylenetetrazol (PTZ), 90 mg/kg, administered subcutaneously to rats." | 3.66 | Serotonin mediation of the protective effect of clonidine against pentylenetetrazol-induced seizures in rats. ( Lazarova, M; Samanin, R, 1983) |
| "Pentylenetetrazole was administered to Swiss-Albino mice, producing clonic-tonic seizures." | 3.66 | Pentylenetetrazole induced changes in cerebellar energy metabolism. ( McCandless, DM; Schwartzenburg, FC, 1982) |
| " Blockade of tonic hindlimb extension in the maximal electroshock test and blockade of tonic and clonic seizures produced by pentylenetetrazole and bicuculline were obtained by elevating GABA in the ventral midbrain tegmentum." | 3.66 | Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid. ( Gale, K; Iadarola, MJ, 1982) |
| "Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia." | 3.66 | Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia. ( Amory, DW; Heavner, JE, 1981) |
| "Midbrain tegmental lesions, which prevent the hindlimb extensor (HLE) component of maximal electroshock seizures (MES), were found to have no effect on the electroshock, flurothyl, or pentylenetetrazol (PTZ) seizures thresholds." | 3.66 | Antagonism of experimentally induced tonic seizures following a lesion in the midbrain tegmentum. ( Browning, RA; Simonton, RL; Turner, FJ, 1981) |
| "Fluorometry and dual-wave-length spectrophotometry were used to detect transitory shifts in the redox state of mitochondrial NADH and cytochrome aa3 in the exposed cerebral cortex of anesthetized paralyzed cats as seizures were induced with pentylenetetrazol." | 3.66 | Redox transitions in mitochondria of cat cerebral cortex with seizures and hemorrhagic hypotension. ( Hempel, FG; Kariman, K; Saltzman, HA, 1980) |
| "Changes in cortical extracellular potassium activity ([K+]0), NADH fluorescence, and oxygen consumption were studied in anesthetized cats during pentylenetetrazol seizures." | 3.66 | Effects of ischemia on the removal of extracellular potassium in cat cortex during pentylenetetrazol seizures. ( Mutsuga, N; Schuette, WH; Vern, BA; Whitehouse, WC, 1979) |
| " In animals pretreated with reserpine, propranolol, or aminophylline, pentylenetetrazol seizures were more severe, cyclic AMP elevations were attenuated or blocked, and cyclic GMP increases were unaffected or augmented." | 3.66 | Effects of reserpine, propranolol, and aminophylline on seizure activity and CNS cyclic nucleotides. ( Ferrendelli, JA; Gross, RA, 1979) |
| " Intracerebroventricular administration of inosine to mice of the C3H/HEN and NIH general purpose strains caused a dose- and time-dependent increase in the latency to clonicotonic seizures produced by intraperitoneal administration of the convulsant pentylenetetrazole." | 3.66 | Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures. ( Marangos, PJ; Moncada, V; Paugh, BA; Paul, SM; Skolnick, P; Syapin, PJ, 1979) |
| "The onset of sustained multiple unit activity (MUA) in corticofugal axons was found to precede the onset of tonic EEG activity in 91 of 92 seizures produced by administering pentylenetetrazol, strychnine, or dieldrin to cats." | 3.66 | Correlations between EEG and multiple unit activity of cortifugal axons at the onset of drug induced seizures in cats. ( Joy, RM, 1978) |
| "The neutral glycolipids of rabbit central cortex were analyzed during epileptic seizures produced by insulin or pentetrazol injection." | 3.66 | Effect of insulin-induced epileptic seizures on neutral glycolipids of rabbit cerebral cortex. ( Freysz, L; Mandel, P; Mesdjian, D; Mesdjian, JL; Rebel, G, 1978) |
| "Seizures induced in the rat by electroshock or by injections of pentylenetetrazol increase the specific binding of diazepam to putative receptor sites in cerebral cortical membranes." | 3.66 | Rapid changes in brain benzodiazepine receptors after experimental seizures. ( Paul, SM; Skolnick, P, 1978) |
| " Amantadine in a dose of 25 mg/kg and particularly markedly in a dose of 100 mg/kg potentaites convulsive seizures." | 3.66 | On certain effects of dopaminergic agents in pentylenetetrazol convulsions. ( Lazarova, MB; Roussinov, KS, 1978) |
| "The influence of pharmacological modifications of the functional activity of the central histaminergic system was studied on the susceptibility of mice to pentylenetetrazol-induced minimal (clonic) and maximal (tonic) seizures." | 3.65 | Studies on the effects of histaminergic agents on seizure susceptibility in mice. ( Gerald, MC; Richter, NA, 1976) |
| " Dantrolene, a muscle contraction antagonist, and MI-65-S, a muscle spindle suppressant, significantly delayed THE." | 3.65 | Blockade of the tonic hindlimb extensor component of maximal electroshock and pentylenetetrazol-induced seizures by drugs acting on muscle and muscle spindle systems: a perspective on method. ( Anderson, RJ; Britton, LW; Helke, CJ; Iadarola, MJ; Raines, A, 1976) |
| " Mice pretreated with procaine, lidocaine, and tetracaine had a lower incidence of seizures when convulsive doses of either nikethamide or doxapram hydrochloride were given intraperitoneally." | 3.65 | Interaction between local anesthetics and analeptic drugs. ( Aldrete, JA; Thompson, RG, 1975) |
| "The activity of the dissociative anaesthetics ketamine and gamma-hydroxybutyrate against seizures induced by mercaptopropionate and pentylenetetrazol have been determined." | 3.65 | The anticonvulsant activity of ketamine agains siezures induced by pentylenetetrazol and mercaptopropionic acid. ( Taberner, PV, 1976) |
| " Of particular interest are 1,3-bis(methoxymethyl)-5,5-diphenylhydantoin and 3-acetoxymethyl-5-ethyl-5-phenylhydantoin, which show good activity against maximal electroshock seizures, and 3-methoxymethyl-5-ethyl-5-phenylhydantoin, which is effective against both maximal electroshock and pentylenetetrazole." | 3.65 | Anticonvulsants. 5. Derivatives of 5-ethyl-5-phenylhydantoin and 5,5-diphenylhydantoin. ( O'Dea, MH; Reinhard, JF; Samour, CM; Vida, JA, 1975) |
| " Pentylenetetrazol was given intraveneously in 50-mg increments or 4% enflurane was inspired until grand mal seizures occurred spontaneously or were triggered by photic or auditory stimuli." | 3.65 | Effects of acute and chronic paleocerebellar stimulation on experimental models of epilepsy in the cat: studies with enflurane, pentylenetetrazol, penicillin, and chloralose. ( Bickford, RG; Burchiel, KJ; Myers, RR; Stockard, JJ, 1975) |
| "Reserpine analogues obtained from strip-down parts of the parent molecule were studied for their effects on experimental convulsive seizures and amphetamine antagonism." | 3.65 | Pharmacological actions of some simple analogues of reserpine. II. Anticonvulsant effects. ( Bhattacharya, IC; Ghosh, DK; Majumdar, DN, 1975) |
| "The anticonvulsive properties of orally administered cinnarizine [(E)-1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine], its difluoro derivative flunarizine [(E)-1-(bis-(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-piperazine], diphenylhydantoin and phenobarbital, were studied against maximal metrazol seizures (MMS) in rats and maximal electroshock seizures (MES) in mice." | 3.65 | Anticonvulsive properties of cinnarizine and flunarizine in rats and mice. ( Desmedt, LK; Janssen, PA; Niemegeers, CJ, 1975) |
| ", the maximal electroshock test (MES), and seizures induced by pentylenetetrazol, strychnine and nicotine." | 3.65 | Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs. ( Barry, H; Sofia, RD; Solomon, TA, 1976) |
| "The concentration of adenosine triphosphate in the brain decreased before the onset of generalized convulsions in unanesthetized rats subjected to acute hypoxia or treated with hydroxylamine or pentylenetetrazole (Metrazol)." | 3.65 | Brain adenosine triphosphate: decreased concentration precedes convulsions. ( Currie, WD; Kramer, RS; Sanders, AP; Woodhall, B, 1970) |
| " Cycloheximide, which antagonizes the puromycin-induced amnesia 3 hours after training, also antagonizes the puromycin effect on susceptibility to seizure." | 3.64 | Puromycin effect on memory may be due to occult seizures. ( Barondes, SH; Cohen, HD, 1967) |
| "Epilepsy is a neurological disorder affecting both children and adults, and many aspects of this disease are still poorly understood." | 3.01 | Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions. ( D'Amora, M; De Angelis, F; Faraguna, U; Galgani, A; Giorgi, FS; Marchese, M; Tantussi, F, 2023) |
| "The main outcomes assessed were seizure scores and locomotion." | 3.01 | Chemically-induced epileptic seizures in zebrafish: A systematic review. ( Benvenutti, R; Calcagnotto, ME; Chitolina, R; Gallas-Lopes, M; Herrmann, AP; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| "Since 1993, over 20 new anti-seizure drugs (ASDs) have been identified in well-established animal seizure and epilepsy models and subsequently demonstrated to be clinically effective in double-blinded, placebo-controlled clinical trials in patients with focal onset seizures." | 2.66 | Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening. ( Barker-Haliski, M; Steve White, H, 2020) |
| "Seizures are a combination of electrical and behavioral events that can induce biochemical, molecular, and anatomic changes." | 2.66 | Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits. ( Adem, A; Alachkar, A; Frank, A; Ojha, SK; Sadek, B; Sadeq, A; Stark, H, 2020) |
| "Patients with epilepsy are often affected by not only seizures but also a variety of cognitive and psychiatric comorbidities that further impair their quality of life." | 2.61 | [Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor]. ( Takechi, K, 2019) |
| "Furthermore, testosterone's antiseizure effects may involve actions of its 5alpha-reduced metabolite and neuroactive steroid, 5alpha-androstane-3alpha,17beta-diol (3alpha-diol)." | 2.42 | Androgens in the hippocampus can alter, and be altered by, ictal activity. ( Frye, CA; Rhodes, ME, 2004) |
| "GABA related drugs acting on PTZ clonic seizures tend to induce sedation and muscle hypotonia." | 2.41 | Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs. ( Meldrum, B, 2002) |
| "Epilepsy is a common neurological disorder affecting more than 70 million people worldwide." | 1.91 | ( Gao, Y; Jiang, X; Liang, X; Liu, W; Lu, H; Wang, N; Xing, B; Xu, X; Zhao, Q; Zhou, L, 2023) |
| "Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue that is used to treat type-2 diabetes mellitus." | 1.91 | The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties. ( Erbas, O; Erdogan, A; Erdogan, MA, 2023) |
| "PTZ gradually provoked seizure-related behaviors." | 1.91 | The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure. ( Abnous, K; Gorji Valokola, M; Heydari, FS; Mehri, S; Roohbakhsh, A, 2023) |
| "Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into novel pharmacological therapies." | 1.91 | Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions. ( Erbas, O; Erdogan, A; Erdogan, MA; Gurgul, S, 2023) |
| "Nocturnal epilepsy is a neurological disease that has a significant effect on sleep." | 1.91 | Effect of valproate on sleep patterns disturbed by epilepsy. ( Ayala-Guerrero, F; Castro-Domínguez, D; Gutiérrez-Chávez, CA; Mateos-Salgado, EL; Mexicano-Medina, G, 2023) |
| "PTZ was used for the induction of seizures." | 1.91 | Chronic stress but not acute stress decreases the seizure threshold in PTZ-induced seizure in mice: role of inflammatory response and oxidative stress. ( Amini-Khoei, H; Bijad, E; Dehkordi, HT; Korrani, MS; Saghaei, E, 2023) |
| "Early onset of PTZ-induced seizure-like behavioural scores, the heightened intensity of seizure and reduced latency in different scores were found in PG and CPFX-administered groups." | 1.91 | Antibiotics modulate frequency and early generation of epileptic seizures in zebrafish. ( Ramachandran, B; Sivarajan, D, 2023) |
| "Epilepsy is characterized by the manifestation of spontaneous and recurrent seizures." | 1.91 | The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish. ( Bertoncello, KT; Bonan, CD, 2023) |
| "Tacrolimus pre-treatment dose-dependently resulted in lesser seizure severity according to Racine's scale, delayed start-up latency of the first myoclonic jerk and attenuated the spike percentages detected by EEG in seizure-induced rats." | 1.91 | Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats. ( Egilmez, CB; Erbas, O; Erdogan, MA; Pazarlar, BA, 2023) |
| "Epilepsy is a complex neurological disease characterized by spontaneous recurrent seizures that affect around 1% of the global population." | 1.91 | Comprehensive characterization of amino acids and water-soluble vitamins in a pentylenetetrazole-induced seizures rat model. ( Jiang, X; Liu, J; Wang, Y, 2023) |
| "The administration of TMP reduced the seizure score and percentage of kindled animals dose-dependently." | 1.91 | Tetramethylpyrazine contributes to the neuroprotection in a rodent epileptic model of pentylenetetrazole-induced kindling. ( Danduga, RCSR; Kanakaraju, VK; Kandaswamy, S; Kola, PK; Polopalli, S; Shaik, HB, 2023) |
| "CA6 and CA12 (p." | 1.91 | Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment. ( Nieoczym, D; Pieróg, M; Samorek-Pieróg, M; Socała, K; Wlaź, P; Wyska, E, 2023) |
| "Pretreatment with rosiglitazone significantly prevented the progression of kindling in comparison with control group." | 1.91 | Effect of Rosiglitazone, the Peroxisome Proliferator-Activated Receptor (PPAR)-γ Agonist, on Apoptosis, Inflammatory Cytokines and Oxidative Stress in pentylenetetrazole-Induced Seizures in Kindled Mice. ( Amini, A; Ayatollahi, AA; Chen, S; Koohsar, F; Li, J; Wang, F; Zeyghami, MA; Zhang, J, 2023) |
| "Epilepsy is one of the most serious worldwide neurological disorders that lead to the cognitive-psychosocial insults in recurrent seizures." | 1.91 | Ceftriaxone and selenium mitigate seizures and neuronal injury in pentylenetetrazole-kindled rats: Oxidative stress and inflammatory pathway. ( Abdelaziz, EZ; Ali, DA; Kolieb, E; Mohamed, AM, 2023) |
| " A major challenge lies in the lack of knowledge about the bioavailability and pharmacodynamic effects of bioactive compounds in this model organism." | 1.91 | Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation. ( Budzyńska, B; Gertsch, J; Kozioł, E; Lee, SM; Morozova, V; Pellegata, D; Skalicka-Woźniak, K; Skiba, A, 2023) |
| " Berberine (BBR), an isoquinoline alkaloid, has shown promising effect in the kindling model of epileptogenesis, but due to the poor oral bioavailability its clinical application is limited." | 1.91 | Neuroprotective effect of Berberine Nanoparticles Against Seizures in Pentylenetetrazole Induced Kindling Model of Epileptogenesis: Role of Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms. ( Bhatia, A; Bhattacharya, S; Chakrabarti, A; Gautam, V; Kumari, P; Rawat, K; Saha, L; Sandhu, A; Singh, N; Sinha, VR, 2023) |
| "While CCI mice have no change in seizure susceptibility at 7d post-injury (dpi), at 70dpi they have reduced latency to PTZ-induced seizure onset, higher seizure frequency and longer seizure duration." | 1.91 | Delayed treatment with ceftriaxone reverses the enhanced sensitivity of TBI mice to chemically-induced seizures. ( Burns, MP; Harvey, AC; Longo, BM; Main, BS; Romariz, SAA, 2023) |
| " Following that, mice were intraperitoneally given a single convulsive dosage of PTZ (60 mg/kg) and then monitored for 30 min for symptoms of seizures." | 1.91 | Neuroprotective anticonvulsant and anxiolytic effects of octreotide in wistar rats. ( Abdolmaleki, A; Asadi, A; Hassanpour, H; Shayan, TK, 2023) |
| "Meanwhile, it decreased the seizure severity and reduced seizure-caused anxious behavior in the PTZ-kindling mice, suggesting a significant antiepileptic activity and anxiolytic/anxiogenic potential." | 1.91 | Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway. ( He, X; Liu, Y; Xie, Y; Yang, Y; Yuan, X, 2023) |
| "Epilepsy is a chronic brain disorder characterized by unprovoked and recurrent seizures, of which 60% are of unknown etiology." | 1.91 | Seizure-induced increase in microglial cell population in the developing zebrafish brain. ( Ameli, C; Cordero-Maldonado, ML; Crawford, AD; Donato, C; Martins, TG; Mombaerts, L; Peri, F; Skupin, A; Soliman, R, 2023) |
| "Seizures were evoked by adding PTZ solution to obtain a final concentration of 20 mM." | 1.91 | Optimization of the Zebrafish Larvae Pentylenetetrazol-Induced Seizure Model for the Study of Caffeine and Topiramate Interactions. ( Bartoszek, A; Fornal, E; Kozub, A; Trzpil, A, 2023) |
| "Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population." | 1.91 | Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| "Epilepsy is a chronic neurological disease with recurrent seizures." | 1.91 | Can endoplasmic reticulum stress observed in the PTZ-kindling model seizures be prevented with TUDCA and 4-PBA? ( Akyüz, E; Ateş, Ş; Doğanyiğit, Z; Okan, A; Shaikh, MF; Taheri, S; Yılmaz, S; Yılmaz, Z, 2023) |
| "CCN1 decreasing effectively prolongs seizure incubation period and decreases seizure duration." | 1.91 | Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice. ( Huang, S; Liao, Y; Zhang, H; Zhang, Y; Zhao, H, 2023) |
| "Epilepsy is a chronic neurological condition that disrupts the normal functioning of the brain and it is characterized by seizures." | 1.91 | Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties. ( Amidu, SB; Boamah, VE; Ekuadzi, E; Mante, PK, 2023) |
| "The treatment with sinigrin significantly delayed the appearance of the seizure symptoms in comparison to that of the PTZ group." | 1.72 | Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway. ( Aghaie, F; Hosseini, A; Koneshlou, S; Moradifar, F; Rajabi, M, 2022) |
| "Sumatriptan is a specific 5-Hydroxytryptamine 1B/1D receptor agonist and has neuroprotective effects in various neuropsychiatric disorders." | 1.72 | Neuroprotective effect of sumatriptan in pentylenetetrazole-induced seizure is mediated through N-methyl-D-aspartate/nitric oxide and cAMP response element-binding protein signaling pathway. ( Abdollahi, A; Alotaibi, G; Dehpour, AR; Ghazi-Khansari, M; Imran Khan, M; Mumtaz, F; Rashki, A; Shadboorestan, A, 2022) |
| "Treatment with finasteride increased seizure susceptibility and depression due to decreased progesterone and elevated estrogen levels coupled with decreased monoamine and elevated corticosterone levels." | 1.72 | Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy. ( Goel, RK; Pahwa, P; Singh, T, 2022) |
| "nitidula leaves showed significant anti-seizure effects in the primary screen and were selected for further study." | 1.72 | Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae. ( Aizawa, H; Gwedela, MNV; Lampiao, F; Matsunami, K; Terai, H, 2022) |
| "Dravet syndrome is characterized by multiple seizure types: generalized tonic-clonic, focal, myoclonic, and absence seizures." | 1.72 | Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels. ( Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M, 2022) |
| "Seizures are a disorder caused by structural brain lesions, life-threatening metabolic derangements, or drug toxicity." | 1.72 | Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside. ( Andrade, AR; Barbas, LAL; Ferreira, LO; Hamoy, AO; Hamoy, M; Jóia de Mello, V; Leitão, DS; Lopes, DCF; Martins, MFC; Medeiros, NCL; Muto, NA; Santos, VC, 2022) |
| "Epilepsy is a neurological disease that pathologically affects brain functions." | 1.72 | Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus. ( Acar, S; Akbas, F; Gorucu Yilmaz, Ş; Meral, I; Okur, SK; Pala Acikgoz, N; Pala, M; Taslidere, E, 2022) |
| " Hence, reducing VPA dosage to minimize side effects while maintaining its efficacy is necessary, and transcranial photobiomodulation (tPBM) add-on therapy could facilitate this." | 1.72 | Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats. ( Chang, H; Chang, SF; Tsai, CM, 2022) |
| "Among models of acutely evoked seizures, whereas anticonvulsive effects of soticlestat were identified in Frings mice, a genetic model of audiogenic seizures, it was found ineffective in MES, acute PTZ seizures, and 6-Hz seizures." | 1.72 | Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor. ( Fujimoto, S; Hasegawa, S; Kondo, S; Metcalf, CS; Miyamoto, M; Nishi, T; Sunahara, E; Watanabe, S; White, HS, 2022) |
| "A coil method was used to detect motor seizures consisting of small amplitude 19-21 Hz muscle contractions." | 1.72 | Detection of pentylenetetrazol-induced seizure activity in the 19-21 Hz beta range using a magnetic coil induction method. ( Chang, WJ; Lu, HC; Shyu, BC; Wei Huang, AC, 2022) |
| " However, the low bioavailability of resveratrol and the difficulty of reaching the targeted location in the brain reduce its efficacy considerably." | 1.72 | Resveratrol-Loaded Glutathione-Coated Collagen Nanoparticles Attenuate Acute Seizures by Inhibiting HMGB1 and TLR-4 in the Hippocampus of Mice. ( Aggarwal, NB; Akhter, J; Arora, I; Asad, M; Hoda, U; Rastogi, S; Samim, M; Siddiqui, MA, 2022) |
| "Allopurinol increases the seizure threshold in PTZ-induced seizure and enhances the survival rate in MES-induced seizure." | 1.72 | The possible role of nitric oxide signaling and NMDA receptors in allopurinol effect on maximal electroshock- and pentylenetetrazol-induced seizures in mice. ( Asgari Dafe, E; Dehpour, AR; Faghir-Ghanesefat, H; Farzad Maroufi, S; Modabberi, S; Rahimi, N; Shayan, M, 2022) |
| "However, the effect of 5-HT7 on seizures has not been exactly elucidated yet." | 1.72 | The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats. ( Ergul, M; Gumus, E; Ozdemir, E; Sahin, B; Taskiran, AS, 2022) |
| "We optimized a locomotor-based seizure assay in zebrafish with pentylenetetrazol (PTZ) as the pharmacological proconvulsant to generate a therapeutic window in which proconvulsant-treated zebrafish larvae could be discriminated from a non-treated control." | 1.72 | Optimization of a locomotion-based zebrafish seizure model. ( Luyten, W; Panda, SK; Shaw, PAG; Stanca, A, 2022) |
| "Evidence suggests that improving brain inflammation can inhibit the epileptogenesis process and help the emergence of new drugs for the treatment of epilepsy." | 1.72 | Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model. ( Akkaya, R; Filiz, AK; Karabulut, S, 2022) |
| "Epileptic seizures are associated with the overproduction of free radicals in the brain leading to neuronal cell death." | 1.72 | The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice. ( Dehdashtian, E; Hosseinzadeh, A; Jafari-Sabet, M; Mehrzadi, S, 2022) |
| "MES and PTZ-induced seizure models were utilized to evaluate the antiepileptic effect of the prepared ligands." | 1.72 | Pyrrolopyridine and Isoindole as Potential Anticonvulsant Agents: Design, Synthesis, and Pharmacological Evaluation. ( Behbahaninia, K; Davood, A; Jahromy, MH; Taghizad, S, 2022) |
| "We induced seizure using intravenous administration of PTZ." | 1.72 | The Role of the NMDA Receptor in the Anticonvulsant Effect of Ellagic Acid in Pentylenetetrazole-Induced Seizures in Male Mice. ( Amini-Khoei, H; Boroujeni, SN; Lorigooini, Z; Rahimi-Madiseh, M; Taji, M, 2022) |
| "Epilepsy was attenuated in AG490 and miR-146a agomir + AG490 groups compared with that in Model group." | 1.72 | miR-146a/KLF4 axis in epileptic mice: A novel regulator of synaptic plasticity involving STAT3 signaling. ( Chen, J; Chen, Y; Li, Y, 2022) |
| "Epilepsy is characterized by the occurrence of seizures, and the high prevalence of epilepsy-associated comorbidities affects the quality of patients' life." | 1.72 | Pentylenetetrazole-induced seizures cause impairment of memory acquisition and consolidation in zebrafish (Danio rerio). ( Bertoncello, KT; Bonan, CD; Zanandrea, R, 2022) |
| "Epilepsy is a common neurological disorder which affects 50 million people worldwide." | 1.72 | Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio). ( Aguiar, GPS; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Piato, A; Schneider, SE; Siebel, AM, 2022) |
| "Malformations of the polymicrogyria spectrum can be mimicked in rodents through neonatal transcranial focal cortical freeze lesions." | 1.72 | Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria. ( Adriani Marques, S; Blanco Martinez, AM; Borges Savoldi, LM; Campello Costa Lopes, P; de Souza Aguiar Dos Santos, DM; Dos Santos Heringer, L; Magalhães Portela, D; Martinez Martinez Toledo, AL; Rios Carvalho, J; Rocha Mendonça, H; Teixeira Oliveira, J; Texeira Silva, B, 2022) |
| "Seizures were induced by pentylenetetrazol and maximal electroshock." | 1.72 | Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 1.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "Ferulic acid treatment, on the other hand, significantly decreased seizure susceptibility and depression like behavior, possibly because of increased progesterone, restored estradiol, corticosterone, monoamines, and GAD enzyme activity." | 1.72 | Ferulic acid inhibits catamenial epilepsy through modulation of female hormones. ( Dhillon, HK; Goel, RK; Singh, T, 2022) |
| "The maximal seizure stage (SS), stage 2 and 4 latency (S2L, S4L), stage 4 and 5 duration (S4D, S5D), and seizure duration (SD) were all assessed 20 min after PTZ administration by observation." | 1.72 | Glial cells inhibition affects the incidence of metaplasticity in the hippocampus of Pentylentetrazole-induced kindled rats. ( Giahi, M; Hosseinmardi, N; Janahmadi, M; Tavassoli, Z, 2022) |
| "CBD inhibited PTZ-induced seizures in mice." | 1.72 | Cannabidiol effect in pentylenetetrazole-induced seizures depends on PI3K. ( Bellozi, PMQ; da Silva, MCM; de Assis Lima, IV; de Oliveira, ACP; Moraes, MFD; Moreira, FA; Pinto, HPP; Vilela, LR, 2022) |
| "Epilepsy is a neurological disorder caused by abnormally elevated neuronal firing and excitability." | 1.72 | Decreased Spire2 Expression is Involved in Epilepsy. ( Guo, Y; Hao, L; Jing, W; Peng, X; Wang, X; Yang, M; Yang, Y; Zhang, H, 2022) |
| " Using an animal model of chemically-induced epileptic seizures, we tested exercise alone as non-pharmacological therapy, and exercise combined with an anti-inflammatory drug." | 1.72 | Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures. ( Barbosa, BB; Coitinho, AS; de Lima Rosa, G; Domingues, AM; Guzzo, EFM; Nunes, SEB; Padilha, RB; Siqueira, IR, 2022) |
| "Caffeine is a psychoactive substance used worldwide." | 1.72 | Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats. ( Araújo, DB; Azevedo, JEC; Barbas, LAL; da Silva, ALM; Hamoy, AO; Hamoy, M; Lopes, DCF; Lopez, MEC; Mello, VJ; Nascimento, CP; Pereira, RG; Rodrigues, SF; Vieira, LR, 2022) |
| "Seizures were observed and scored 30 min after PTZ injection." | 1.72 | Downregulatory effect of miR-342-3p on epileptogenesis in the PTZ-kindling model. ( Acar, S; Akbas, F; Gorucu Yilmaz, S; Meral, I; Okur, SK; Pala Acikgoz, N; Pala, M; Polat, Y, 2022) |
| "Only rats that presented tonic-clonic seizures during the first 1-5 min after PTZ treatment were included in the study." | 1.72 | Pentylenetetrazol-induced seizures are followed by a reduction in the multiunitary activity of hippocampal CA1 pyramidal neurons in adult rats. ( González-Burgos, I; Guevara, MÁ; Hernández-González, M; Romero-Guerrero, C, 2022) |
| "The anti-seizure activity of the extract was assessed in three doses of 25, 50, and 100 mg/kg." | 1.72 | Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat. ( Arabi, M; Fatahinezhad, N; Lorigooini, Z; Rabiei, Z; Rafieian-Kopaei, M; Sheykhshabani, SK, 2022) |
| "One month after the seizures, we detected a moderate neuronal loss in several hippocampal regions: CA1, CA3, and hilus, but not in the dentate gyrus." | 1.72 | Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats. ( Brazhe, AR; Korzhevskii, DE; Nosova, OI; Postnikova, TY; Semyanov, AV; Trofimova, AM; Zaitsev, AV; Zakharova, MV, 2022) |
| "The risk of seizures is 10-fold higher in patients with Alzheimer's disease than the general population, yet the mechanisms underlying this susceptibility and the effects of these seizures are poorly understood." | 1.72 | The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. ( Barbour, AJ; Eberwine, G; Gourmaud, S; Irwin, DJ; Jensen, FE; O'Brien, WT; Roberts, N; Stewart, DA; Talos, DM; Vassar, R, 2022) |
| "The current study evaluates the anticonvulsant effect low dose whole body gamma irradiation (LDR) alone or combined with topiramate against pentylenetetrazole (PTZ)-induced convulsions." | 1.72 | Modulation of PTZ-induced convulsions in rats using topiramate alone or combined with low dose gamma irradiation: involving AKT/m-TOR pathway. ( Hassan, SHM; Kenawy, SA; Lotfy, DM; Safar, MM, 2022) |
| "Their effects on seizure susceptibility and spontaneous epileptic seizures were evaluated with a pentylenetetrazol (PTZ) test in 2 weeks and with continuous video and wireless electroencephalography (EEG) monitoring between 2 and 6 weeks after injury, respectively." | 1.62 | Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice. ( Chai, Z; Jin, X; Ma, C; Ping, X; Wang, W; White, FA, 2021) |
| "oleracea (LEO) on PTZ-induced seizures, using juvenile Colossoma macropomum fish (9." | 1.62 | Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum. ( Barbas, LAL; da Silva, TVN; Hamoy, M; Monserrat, JM; Sampaio, LA; Torres, MF, 2021) |
| "Melatonin has been used in clinical anti-epileptic studies, but its effect on epileptic comorbidities is unknown, and the underlying mechanism needs further investigation." | 1.62 | Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. ( Gao, D; Jin, M; Li, N; Liu, K; Mou, L; Ren, Q; Sik, A; Zhang, M; Zhang, S, 2021) |
| "First myoclonic jerks decreased while seizure severity and total spike count increased in the PTZ group." | 1.62 | Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ-induced kindling rat model. ( Taskiran, M; Unal, G, 2021) |
| "In the search for new antiseizure drugs (ASDs) to treat epilepsy, it is yet unclear which types of coumarins are particularly interesting as a systematic analysis has not been reported." | 1.62 | Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish. ( Budzyńska, B; Copmans, D; de Witte, PAM; Jóźwiak, K; Kozioł, E; Skalicka-Woźniak, K, 2021) |
| "Therefore, early cellular response to seizures in the brain includes induction of the Ntrk2, Ntrk3, Ngfr, miRNA-9, and miRNA-29a expression, as well as activation of Bcl-2 and Bax signaling pathways, which may characterize them as important mediators of neuronal adaptation and survival upon induction of the generalized brain activity." | 1.62 | Early Induction of Neurotrophin Receptor and miRNA Genes in Mouse Brain after Pentilenetetrazole-Induced Neuronal Activity. ( Anokhin, KV; Gruzdeva, AM; Ivashkina, OI; Klimovich, PS; Popov, VS; Rubina, KA; Rysenkova, KD; Semina, EV; Shmakova, AA; Tkachuk, VA, 2021) |
| "The latency, frequency and duration of seizures evaluated using EEG recordings from the frontal and parietal cortices of rats showed significant changes demonstrating the inhibition of paroxystic activity." | 1.62 | Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats. ( Contreras-Murillo, G; González-Trujano, ME; Hidalgo-Flores, FJ; López-Najera, CA; Magdaleno-Madrigal, VM; Navarrete-Castro, A; Sánchez, CG, 2021) |
| "In various organisms, stress is a seizure-related comorbidity." | 1.62 | Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish. ( Canzian, J; Franscescon, F; Müller, TE; Rosa, LV; Rosemberg, DB; Souza, TP; Stefanello, FV, 2021) |
| "Seizures are a threat to the host brain and body and can even cause death in epileptic children." | 1.62 | Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of pentylenetetrazole-induced acute seizure. ( Eor, JY; Kim, SH; Kwak, MJ; Son, YJ; Tan, PL, 2021) |
| "Perampanel is a new antiepileptic drug with unique mechanism of action - antagonism of AMPA receptors." | 1.62 | Perampanel exhibits anticonvulsant action against pentylentetrazol-induced seizures in immature rats. ( Kubová, H; Mareš, P, 2021) |
| "Epileptic seizures are characterized by imbalanced inhibition-excitation cycle that triggers biochemical alterations responsible for jeopardized neuronal integrity." | 1.62 | Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures. ( Mishra, P; Rajput, SK; Sinha, JK, 2021) |
| "We also examined the degree of seizure severity and the modulation of pro-inflammatory cytokines in the treated animals." | 1.62 | Effects of prednisolone on behavioral and inflammatory profile in animal model of PTZ-induced seizure. ( Bremm Padilha, R; de Lima Rosa, G; Dias de Oliveira Amaral, V; Muliterno Domingues, A; Muller Guzzo, E; Simon Coitinho, A, 2021) |
| "Pentylenetetrazole (45 mg/kg) was given to induce a seizure in the tenth day except for the control." | 1.62 | The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats. ( Taskiran, AS; Tastemur, Y, 2021) |
| "In the NE-100-induced seizure model, Sig1R-/- animals demonstrated lower seizure scores, shorter durations and increased latency times of seizures compared to WT mice." | 1.62 | Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures. ( Dambrova, M; Kupats, E; Lauberte, L; Mezapuke, R; Stelfa, G; Svalbe, B; Vavers, E; Vilks, K; Zvejniece, B; Zvejniece, L, 2021) |
| "Seizures were evaluated by video-EEG during one hour and scored according to Racine scale." | 1.62 | Effect of Memantine on Pentylenetetrazol-induced Seizures and EEG Profile in Animal Model of Cortical Malformation. ( Cagliari Zenki, K; Calcagnotto, ME; Klippel Zanona, Q; Lazzarotto, G, 2021) |
| "Seizures were induced in rats (postnatal day 10) by 5% O2 exposure for 15 min." | 1.62 | FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation. ( Farbood, Y; Ghafouri, S; Najafian, SA; Sarkaki, A, 2021) |
| "Epileptic seizures are the most common neurological diseases that change the function of neurovascular unit at molecular levels accompanied by activation of a wide variety of neurodegenerative cascades." | 1.62 | Fenofibrate protects the neurovascular unit and ameliorates plasma corticosterone levels in pentylenetetrazole-induced kindling seizure in mice. ( Darabi, S; Faghihi, N; Mohammadi, MT; Sarahian, N, 2021) |
| "The intensity of convulsion was scored according to a seven-point scale ranging from stage 0-7." | 1.62 | Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice. ( Abiola, AL; Akhigbemen, AM; Chinazamoku, O; Igbe, I; Ogundepo, GE; Okwuofu, EO; Ozolua, RI, 2021) |
| "camptopus in acute models of epileptic seizures in Wistar rats." | 1.62 | Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. ( Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD, 2021) |
| "Pediatric patients with epilepsy are prone to cognitive impairments during growth and long-term use of most antiepileptic drugs (AED)." | 1.62 | Pharmacological Activity of Pyrazole Derivatives as an Anticonvulsant for Benefit against Epilepsy. ( Gao, M; Qu, K; Wang, X; Zhang, W, 2021) |
| "In our model we have measured rat seizure activity with EEG, the convulsion scala of Racine (RCS), the time of first myoclonic jerk (FMJ) and MDA levels to assess if OB has antiepileptic properties." | 1.62 | Effects of the Calcium Channel Blocker Otilonium Bromide on Seizure Activity in Rats With Pentylenetetrazole-Induced Convulsions. ( Atasoy, O; Erbas, O; Erdogan, A; Erdogan, MA, 2021) |
| "Pentylenetetrazole (PTZ) was used to induce convulsions in rats through elevating seizure stages, releasing neuroinflammatory mediators and reducing excitatory amino acid transporter 2 (EAAT 2) and γ-aminobutyric acid (GABA) brain contents." | 1.62 | Single step nanospray drying preparation technique of gabapentin-loaded nanoparticles-mediated brain delivery for effective treatment of PTZ-induced seizures. ( Elhabak, M; Salama, AAA; Salama, AH, 2021) |
| "However, ND with synbiotics seizure reducing effect requires further analysis." | 1.62 | Neuroprotective effect of both synbiotics and ketogenic diet in a pentylenetetrazol-induced acute seizure murine model. ( Eor, JY; Kang, HC; Kim, JH; Kim, JY; Kim, SH; Son, YJ; Youn, SE, 2021) |
| "Therefore, we hypothesized that seizure detection is possible through vagus nerve electroneurogram (VENG) recording." | 1.62 | Vagus Nerve Electroneurogram-Based Detection of Acute Pentylenetetrazol Induced Seizures in Rats. ( Cury, J; Delbeke, J; Doguet, P; El Tahry, R; Nonclercq, A; Smets, H; Stumpp, L; Vespa, S, 2021) |
| "Acute seizures can severely affect brain function and development." | 1.62 | Alterations in mRNA and Protein Expression of Glutamate Receptor Subunits Following Pentylenetetrazole-induced Acute Seizures in Young Rats. ( Kovalenko, AA; Postnikova, TY; Schwarz, AP; Zaitsev, AV; Zakharova, MV; Zubareva, OE, 2021) |
| "On the 15th day, the seizure was induced (except the control group) by intraperitoneal injection of PTZ." | 1.62 | Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress. ( Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Karimi, MY; Mehrzadi, S, 2021) |
| "Epilepsy is a chronic encephalopathy and one of the most common neurological disorders." | 1.62 | Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice. ( Chen, D; Gan, CL; Hu, L; Lan, G; Lee, TH; Liu, H; Mei, Y; Shui, X; Wang, L; Xia, Y; Zhang, T; Zou, Y, 2021) |
| "The latency and duration of induced convulsion, as well as mortality protection percentage were recorded 30 min after PTZ injection." | 1.62 | Effects of probiotics on pentylenetetrazol-induced convulsions in mice. ( Kangi, S; Najimi, S; Rahimi, HR; Sabouri, S, 2021) |
| " Luteolin low bioavailability could be a limiting factor to obtain better results." | 1.62 | Investigation on the Anticonvulsant Potential of Luteolin and Micronized Luteolin in Adult Zebrafish (Danio rerio). ( Aguiar, GPS; Dos Santos, AE; Garbinato, C; Lanza, M; Lima-Rezende, CA; Müller, LG; Pedroso, J; Petry, F; Piato, A; Schneider, SE; Siebel, AM; Vladimir Oliveira, J, 2021) |
| " Curcumin is the principle curcuminoid of Curcuma longa, or colloquially turmeric, and has been experimentally proven to have anti-convulsive properties, but its poor bioavailability has dampened further therapeutic interest." | 1.62 | Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models. ( Abas, F; Choo, BKM; Faudzi, SMM; Kundap, UP; Samarut, É; Shaikh, MF, 2021) |
| "Rats receiving LTG-BF1 recorded reduced seizure scores at all stages, longer latency time, and higher threshold PTZ dose compared to PTZ and market product groups." | 1.62 | Micellar buccal film for safe and effective control of seizures: Preparation, in vitro characterization, ex vivo permeation studies and in vivo assessment. ( Basha, M; Salama, AAA; Salama, AH, 2021) |
| "Epilepsy is a neurodegenerative brain disorder characterized by recurrent seizure attacks." | 1.62 | Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the ( Al Kury, LT; Alattar, A; Alshaman, R; Alvi, AM; Feng, J; Khan, AU; Li, S; Muhammad, AJ; Shah, FA; Ullah, I, 2021) |
| "Ellagic acid (EA) is a natural dietary polyphenol that has many beneficial properties, including anti-inflammatory, antioxidant, antiviral, antibacterial, and neuroprotective effects." | 1.62 | Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice. ( Pieróg, M; Poleszak, E; Socała, K; Wlaź, P; Wyska, E, 2021) |
| "Unregulated neuro-inflammation mediates seizures in temporal lobe epilepsy (TLE)." | 1.62 | Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures. ( Anderson, T; Borenstein, R; Howard, K; Major, CK; Musto, AE; Ojeda, A; Pototskiy, E; Sharma, D; Vinokuroff, K, 2021) |
| "As a result, α-asaronol ameliorated seizures with increase of seizure latency, as well as decrease of seizure-like behavior, c-fos expression, and abnormal neuronal discharge in a concentration dependent manner." | 1.56 | Involvement of peroxisome proliferator-activated receptor γ in anticonvulsant activity of α-asaronol against pentylenetetrazole-induced seizures in zebrafish. ( Bai, Y; Jin, M; Li, X; Liu, K; Sik, A; Sun, Y; Zhang, B; Zhang, S; Zheng, X, 2020) |
| "Increased behavioral manifestations and seizure severity was observed in the stress group compared with the control group at both ages." | 1.56 | Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring. ( Arida, RM; da Silva, EA; Gutierre, RC; Lopim, GM, 2020) |
| "Here, we studied pentylenetetrazole seizure-induced regulation of genes for plasminogen activator system in the mouse brain." | 1.56 | Urokinase receptor and tissue plasminogen activator as immediate-early genes in pentylenetetrazole-induced seizures in the mouse brain. ( Anokhin, KV; Gruzdeva, AM; Ivashkina, OI; Rubina, KA; Rysenkova, KD; Semina, EV; Shmakova, AA; Tkachuk, VA, 2020) |
| "In India, it is used for the treatment of epilepsy as traditional medicine." | 1.56 | An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy. ( Dinda, AK; Kaleekal, T; Katyal, J; Pattnaik, SS; Sarangi, SC, 2020) |
| " The employment of different dosage groups enabled us to characterize the dose range reliably inducing seizures." | 1.56 | Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy. ( De Deyn, PP; Valkenburg, F; Van Dam, D; Van Erum, J, 2020) |
| " Despite its pharmacological properties, the poor bioavailability of resveratrol has been an important barrier that hinders its application as an anticonvulsant." | 1.56 | Micronized resveratrol shows promising effects in a seizure model in zebrafish and signalizes an important advance in epilepsy treatment. ( Aguiar, GPS; Almeida, ER; Decui, L; Garbinato, CLL; Mazon, SC; Müller, LG; Oliveira, JV; Schneider, SE; Siebel, AM, 2020) |
| "Lacosamide (LCM) has been shown to possess complex anticonvulsant and neuroprotective actions, being an enhancer of the slow inactivation of voltage-gated sodium channels, and it has the potential to prevent epileptogenesis." | 1.56 | Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats. ( Gáll, Z; Kelemen, K; Kolcsár, M; Mihály, I; Miklóssy, I; Salamon, P; Zsigmond, B, 2020) |
| "Epileptic seizures are characterized by synchronized discharges of neurons, leading to the activation of inflammatory responses that in turn contributes to seizure progression." | 1.56 | Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. ( Ji, X; Jin, M; Liu, K; Sik, A; Wang, L; Zhang, B; Zhang, S, 2020) |
| "EPO pretreatment decreased seizure severity and prolonged seizure latency." | 1.56 | Effects of erythropoietin pretreatment on single dose pentylentetrazole-induced seizures in rats. ( Akgün-Dar, K; Kaptan, Z; Kapucu, A; Üzüm, G, 2020) |
| "Mean total seizure score decreased by 48." | 1.56 | Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures. ( Abdel-Salam, OME; Sayed, MAEBM; Shaffie, N; Sleem, AA; Youness, ER, 2020) |
| "Recurrent seizures induce some cognitive problems, such as, depression, learning and memory deficits, and neurodegeneration." | 1.56 | Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole. ( Beheshti, S; Doostmohammadi, M; Pourhossein Majarshin, F; Yazdi, A, 2020) |
| "Salvinorin A is a potent plant-derived hallucinogen that acts as a highly selective κ-opioid receptor agonist." | 1.56 | Salvinorin A Does Not Affect Seizure Threshold in Mice. ( Doboszewska, U; Socała, K; Wlaź, P, 2020) |
| "Seizures were induced by intravenous PTZ infusion." | 1.56 | Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. ( Heydari, A; Jamali, H, 2020) |
| "Convulsive status epilepticus is the most common neurological emergency in children." | 1.56 | Transcranial photobiomodulation attenuates pentylenetetrazole-induced status epilepticus in peripubertal rats. ( Chang, H; Chang, SF; Tsai, CM, 2020) |
| "The antiseizure activity of BERB was shown previously in experimental epilepsy models." | 1.56 | The Influence of Palmatine Isolated from ( Banono, NS; Ent, WV; Esguerra, CV; Gawel, K; Kukula-Koch, W; Nieoczym, D; Stepnik, K; Tarabasz, D; Turski, WA, 2020) |
| "Pretreatment with daidzin remarkably reduced the severity of epileptogenesis in a dose-dependent manner." | 1.56 | Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling. ( Kazmi, Z; Khan, A; Khan, S; Malik, S; Seo, EK; Shehzad, A; Zeeshan, S, 2020) |
| "Recurrent seizures or persistent seizures may cause irreversible brain damage." | 1.56 | MS275 reduces seizure-induced brain damage in developing rats by regulating p38 MAPK signaling pathways and epigenetic modification. ( Hu, QP; Huang, XY; Peng, F; Wu, C; Yang, H, 2020) |
| "In all dosing regimens, ziconotide significantly decreased the seizure frequency and also delayed the latency period compared with control." | 1.56 | Intracerebroventricular administration of N-type calcium channel blocker ziconotide displays anticonvulsant, anxiolytic, and sedative effects in rats: A preclinical and pilot study. ( Bozorgi, H; Budde, T; Zamani, M, 2020) |
| "As seizures are commonly associated with autonomic manifestations, we believe that biomarkers for diseases affecting autonomic functions such as epilepsy can be found in vagus nerve signals." | 1.56 | Recording of spontaneous vagus nerve activity during Pentylenetetrazol-induced seizures in rats. ( Cury, J; Delbeke, J; Doguet, P; Hermans, E; Nielsen, TN; Nonclercq, A; Sevcencu, C; Smets, H; Stumpp, L; Tahry, RE; Vespa, S, 2020) |
| "Epileptic seizures constitute a significant comorbidity of Alzheimer's disease (AD), which are recapitulated in transgenic mouse models of amyloidogenesis." | 1.56 | Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy. ( Basquin, M; Blum, D; Boison, D; Buée, L; Ferry, B; Gomez-Murcia, V; Laurent, C; Parrot, S; Sandau, U, 2020) |
| "Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical-imaging syndrome as well as a critical maternal complication." | 1.56 | Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study. ( Chen, D; Fang, X; Liang, Y; Liu, Y; Xie, M; Zhang, W, 2020) |
| "Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic." | 1.56 | Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion. ( Albayrak, Y; Atasoy, Ö; Beyazyüz, M; Durankuş, F; Erbaş, O; Şenkal, E; Sünnetçi, E, 2020) |
| "A dose-dependent biphasic seizure modulation of morphine was demonstrated in the acute treatment with morphine; acute treatment at a dose of 0." | 1.56 | Interaction of morphine tolerance with pentylenetetrazole-induced seizure threshold in mice: The role of NMDA-receptor/NO pathway. ( Aghaei, I; Bahremand, T; Dehpour, AR; Ejtemaei-Mehr, S; Rahimi, N; Shafaroodi, H; Shayan, M; Zamanian, G, 2020) |
| "A rat model of convulsion in the developmental stage was prepared by an intraperitoneal injection of PTZ." | 1.56 | [Regulatory mechanism of MS275 on the p38 MAPK signaling pathway in rats with convulsion in the developmental stage]. ( Hu, QP; Huang, XY; Peng, F, 2020) |
| "New mouse models of epilepsy are needed to better understand the complex genetic architecture of seizures and to identify therapeutics." | 1.56 | Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. ( Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH, 2020) |
| "Here, we investigated the seizure susceptibility and the role of NRG1-ErbB4 signaling in PV interneurons in the suppression of epileptic seizures for rats subject to early life hypoxia." | 1.56 | Increased Seizure Susceptibility for Rats Subject to Early Life Hypoxia Might Be Associated with Brain Dysfunction of NRG1-ErbB4 Signaling in Parvalbumin Interneurons. ( Ding, W; Fan, F; Fang, Y; Hu, L; Lei, B; Liang, D; Zhang, M, 2020) |
| "In contrast, the same ES inhibited EEG seizures when delivered after a combination of DIA‑1." | 1.56 | Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats. ( Godlevsky, LS; Pervak, MP; Shandra, AA; Shandra, OO, 2020) |
| "Previous studies have shown that seizures can cause cognitive disorders." | 1.56 | Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. ( Arabi, M; Bijad, E; Kazemi, S; Lorigooini, Z; Mahmoudi, T; Rabiei, Z; Rafieian-Kopaei, M, 2020) |
| "After knockdown of Sema7A, seizure activity was suppressed based on the latency to the first epileptic seizure, number of seizures, and duration of seizures." | 1.56 | Sema7A, a brain immune regulator, regulates seizure activity in PTZ-kindled epileptic rats. ( Chen, YM; Deng, J; Fu, J; Jiang, Q; Li, Q; Li, R; Ma, JX; Xu, T; Yang, J; Yu, XY; Zhang, KM, 2020) |
| "Epilepsy seizures was induced by repetitive injections of pentylenetetrazol at a dose of 37 mg per kg." | 1.51 | Propionate relieves pentylenetetrazol-induced seizures, consequent mitochondrial disruption, neuron necrosis and neurological deficits in mice. ( Cheng, Y; Ding, H; Li, J; Mai, Q; Tang, L; Wang, H; Xiao, Y; Zeng, X; Zhang, Y, 2019) |
| "Paeonol can also increase the activities of total antioxidant capacity, SOD and catalase activity and reduce MDA content as well." | 1.51 | Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats. ( Agbo, E; Liu, DH; Zhang, SH; Zhu, JL, 2019) |
| "Furthermore, PTZ evoked seizure severity was considerably decreased, while latency to clonic-like seizure was increased in adult zebrafish group treated with 100 nM of LY294002." | 1.51 | Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. ( Kumari, S; Mazumder, AG; Singh, D, 2019) |
| "What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inflammatory effects? What is the main finding and its importance? Chronic administration of oestrogen, progesterone, ER modulators/agonists or blockade of testosterone exhibited anti-inflammatory and antioxidant actions on single seizure-induced neuronal injury, while ER agonists additionally improved memory function and up-regulated CREB signalling and hippocampal GABA(A)α1 receptor density, suggesting that ERα or ERβ receptor activation may be beneficial in protecting against seizure-related oxidative brain injury and cognitive dysfunction." | 1.51 | Oestrogen receptor ERα and ERβ agonists ameliorate oxidative brain injury and improve memory dysfunction in rats with an epileptic seizure. ( Akakın, D; Arabacı Tamer, S; Erzik, C; Karagöz, A; Koyuncuoğlu, T; Yeğen, BÇ; Yüksel, M, 2019) |
| "Pentylenetetrazole-treated FVB/NJ and C57BL/6NJ strains of mice showed strong, clear seizure responses." | 1.51 | Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration. ( Adhikari, A; Copping, NA; Petkova, SP; Silverman, JL, 2019) |
| "Taurine (TAU) is an amino sulfonic acid which acts an endogenous inhibitory neuromodulator." | 1.51 | Taurine Protects from Pentylenetetrazole-Induced Behavioral and Neurochemical Changes in Zebrafish. ( Barbosa, NV; Canzian, J; Dos Santos, MM; Fontana, BD; Loro, VL; Mello, CF; Mezzomo, NJ; Müller, TE; Rosemberg, DB; Ziani, PR, 2019) |
| "The animals were assessed for seizure score, neuronal damage and inflammatory cytokines levels (IL-1β, IL-6 and TNF-α) in hippocampus." | 1.51 | Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats. ( Banerjee, D; Bhatia, A; Chakrabarti, A; Kumari, P; Saha, L; Singh, J; Singh, N, 2019) |
| "IVA attenuated PTZ- and PICRO-induced seizures while presented an antioxidant effect in all brain areas studied." | 1.51 | Ivabradine possesses anticonvulsant and neuroprotective action in mice. ( Aguiar, CCT; Bessa, MC; Borges, LTN; Campos, AR; Cavalcante, TMB; Chaves Filho, AJM; De Melo, JMA; Fonteles, MMF; Lopes, LB; Macêdo, D; Santos, JG; Vasconcelos, LC; Vasconcelos, SMM; Vieira Neto, AE, 2019) |
| "This study aims to identify the anti-seizure components from Semen Pharbitidis." | 1.51 | Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model. ( Copmans, D; de Witte, PAM; Jiang, ZH; Liu, M; Lu, JG; Luyten, W; Ny, A; Sourbron, J; Yang, MR, 2019) |
| "Determination of seizure threshold revealed significant enhancement after preconditioning with low dose of PTZ." | 1.51 | The Possible Role of Nitric Oxide Pathway in Pentylenetetrazole Preconditioning Against Seizure in Mice. ( Bahramnejad, E; Dehpour, AR; Faghir-Ghanesefat, H; Kazemi Roodsari, S; Keshavarz-Bahaghighat, H; Mokhtari, T; Rajai, N, 2019) |
| "In the pentylenetetrazol (PTZ) seizure-susceptibility test, dKO mice had a shorter latency to the first epileptiform spike (p = 0." | 1.51 | Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility. ( Bolkvadze, T; Ekolle Ndode-Ekane, X; Koivisto, H; Kyyriäinen, J; Lipponen, A; Pérez, LO; Pitkänen, A; Tanila, H, 2019) |
| "Acute seizures were induced in zebrafish using pentylenetetrazol (PTZ) and cognitive function was assessed using the T-maze test of learning and memory." | 1.51 | Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model. ( Choo, BKM; Johan Arief, MFB; Kumari, Y; Kundap, UP; Othman, I; Shaikh, MF; Wong, CP; Yap, JL, 2019) |
| "Methadone is a synthetic opioid used to treat opiate withdrawal and addiction." | 1.51 | Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling. ( Aghaei, I; Bahramnejad, E; Dehpour, AR; Kazemi Roodsari, S; Rahimi, N, 2019) |
| "Thereafter, PTZ seizure threshold was measured in control and treated rats, and different brain regions were analyzed for levels of oxidative stress biomarkers." | 1.51 | Vitamin E modifies high-fat diet-induced reduction of seizure threshold in rats: Role of oxidative stress. ( Al Yacoub, ON; Alomari, MA; Alrabadi, NN; Alzoubi, KH; Banihani, SA; Hasan, ZA; Khabour, OF; Mayyas, FA, 2019) |
| "Febrile seizure is a common neurological disorder observed in neonates." | 1.51 | Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures. ( Moghimi, A; Roohbakhsh, A; Zandi, N; Zaniani, NR, 2019) |
| "Epilepsy is a group of neurological disorders characterized by recurrent seizures that disturbs about 60 million people worldwide." | 1.51 | Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives. ( Bai, Y; Chen, X; He, X; Sun, Y; Wu, S; Xie, J; Zhang, Y; Zhao, Z; Zheng, X, 2019) |
| "The results indicated that more severe seizures, decreased neural density, decreased expression of Bcl-2, increased expression of Bax and cleaved caspase-3, and inactivation of AKT/CREB/BDNF signaling occurred in the 'PTZ' group in comparison with the control group." | 1.51 | Anticonvulsant and anti-apoptosis effects of salvianolic acid B on pentylenetetrazole-kindled rats via AKT/CREB/BDNF signaling. ( Guan, Q; Jin, Y; Lu, X; Shen, H; Wang, Y; Yu, X; Zhai, L, 2019) |
| "Based on the understanding that seizures are the expression of neural hypersynchronism, our group developed and tested a non-standard form of low-energy temporally unstructured ES termed NPS (Non-periodic stimulation), with pseudo-randomized inter-pulse intervals." | 1.51 | Seizure suppression by asynchronous non-periodic electrical stimulation of the amygdala is partially mediated by indirect desynchronization from nucleus accumbens. ( Cota, VR; de Oliveira, JC; Drabowski, BMB; Maciel, RM; Moraes, MFD; Rodrigues, SMAF, 2019) |
| "However, the impact of seizure induced neurogenesis on behaviour remains poorly understood." | 1.51 | Spatial exploration induced expression of immediate early genes Fos and Zif268 in adult-born neurons Is reduced after pentylenetetrazole kindling. ( Carr, J; Fournier, NM; Kalinina, A; Lehmann, H; Maletta, T, 2019) |
| "Animals were divided into sham, seizure, exercise (EX), co-seizure-induced exercise (Co-SI EX) and Pre-SI EX groups." | 1.51 | The effect of exercise on GABA signaling pathway in the model of chemically induced seizures. ( Barzroodi Pour, M; Bayat, M; Eftekharzadeh, M; Golab, F; Karimzadeh, F; Katebi, M; Soleimani, M, 2019) |
| "However, the latency time to seizure onset was unaltered." | 1.51 | The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE. ( Hong, Z; Sun, W; Wang, Y; Wu, X; Xu, L; Zhang, L; Zhu, G, 2019) |
| "The susceptibility to seizures was evaluated by seizure frequency and duration." | 1.51 | Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats. ( Chen, W; Cui, Y; Lin, XY; Wang, L, 2019) |
| "The proposed animal model of seizures is characterized by SW discharges which remain stable for 2 h." | 1.48 | A New Rat Model of Seizures Suitable for Screening Antiepileptic Electrical Stimulation Therapies. ( Harreby, KR; Jensen, W; Jiao, J; Sevcencu, C, 2018) |
| "KD alleviated seizure severity, decreased the number of Fluoro-jade B (FJB)-positive cells in the hippocampus of kindled rats." | 1.48 | Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures. ( Hou, Q; Jia, MM; Jiang, Y; Lu, YQ; Qiu, T; Wang, BH; Wang, XH; Zhang, ZX, 2018) |
| "Pretreatment with genistein delayed seizure onset, reduced the seizure duration, improved oxidative stress profile, decreased estrogen receptor expression, reduced apoptosis, and improved the histopathological pattern." | 1.48 | Effects of genistein on pentylenetetrazole-induced behavioral and neurochemical deficits in ovariectomized rats. ( Elsayed, AA; Ibrahim, BMM; Khalifa, AE; Menze, ET; Sabri, NA; Tadros, MG, 2018) |
| "We assessed the seizure vulnerability and anxiety responses following the chronic co-administration of, and withdrawal from, caffeine and ethanol in male rats." | 1.48 | Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model. ( Alele, PE; Matovu, D, 2018) |
| "Boldine is an aporphine alkaloid which is best known for its antioxidant, anti-inflammatory and cytoprotective characteristics." | 1.48 | Sub-chronic boldine treatment exerts anticonvulsant effects in mice. ( Dastgheib, M; Jamshidzadeh, A; Moezi, L; Pirsalami, F; Yahosseini, S, 2018) |
| "The acute PTZ-induced seizure threshold was also unchanged in mice lacking TIA-1 protein, indicating that this RNA binding protein does not influence the innate seizure threshold." | 1.48 | Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1. ( Gong, Y; Hewett, JA, 2018) |
| "Despite the development of newer anti-seizure medications over the past 50 years, 30-40% of patients with epilepsy remain refractory to treatment." | 1.48 | A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target. ( de la Hoz, CL; Gavrilovici, C; Ibhazehiebo, K; Kaushik, G; Kim, DY; Kurrasch, DM; Ma, SC; Meza Santoscoy, PL; Nath, N; Rehak, R; Rho, JM; Scott, L, 2018) |
| "Sumatriptan has been among the top choices in the management of migraine headaches." | 1.48 | Biphasic effect of sumatriptan on PTZ-induced seizures in mice: Modulation by 5-HT1B/D receptors and NOS/NO pathway. ( Aghamollaii, V; Ahmadi, M; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Rohani, MM; Tafakhori, A, 2018) |
| "Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the influence of tadalafil on seizure susceptibility has not been studied so far." | 1.48 | Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice. ( Doboszewska, U; Nieoczym, D; Pieróg, M; Socała, K; Szafarz, M; Wlaź, P; Wyska, E, 2018) |
| ")-induced tonic-clonic seizures were assayed via a dose-response (100, 200 and 300 mg/kg, i." | 1.48 | Behavioral and electroencephalographic evaluation of the anticonvulsive activity of Moringa oleifera leaf non-polar extracts and one metabolite in PTZ-induced seizures. ( Contreras-Murillo, G; Flores-Carrillo, M; González-Trujano, ME; Luna-Nophal, SI; Magdaleno-Madrigal, VM; Martínez-González, CL, 2018) |
| "Tonic-clonic seizures were induced by an injection of Pentylenetetrazol (80 mg/kg, i." | 1.48 | Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures. ( Moradi-Chameh, H; Palizvan, MR; Sadegh, M; Zareie, P, 2018) |
| "Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet." | 1.48 | Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice. ( Nieoczym, D; Socała, K; Wlaź, P, 2018) |
| "Furthermore, time dependent seizure protection capability of the most potent compound was also evaluated." | 1.48 | Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation. ( Angeli, A; Bua, S; Kumari, S; Mishra, CB; Supuran, CT; Tiwari, M, 2018) |
| "The overexpression of AZGP1 reduced the seizure severity, prolonged the latency of kindling, and alleviated epileptiform discharges in EEG changes induced by PTZ." | 1.48 | Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats. ( Chen, L; Ding, X; Liu, X; Liu, Y; Mo, L; Tan, X; Wang, T; Wei, X; Wen, Y; Xu, T; Yin, M; Yu, X, 2018) |
| "Seizures affect about 50 million people around the world." | 1.48 | Clarified Açaí ( ( Arrifano, GPF; Carvalho, JCT; Crespo-López, ME; Farina, M; Lichtenstein, MP; Rogez, H; Souza-Monteiro, JR; Suñol, C, 2018) |
| "Generalised tonic-clonic seizures, generated by abnormal neuronal hyper-activity, cause a significant and long-lasting increase in the nociceptive threshold." | 1.48 | Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception. ( Almada, RC; Bazaglia-de-Sousa, G; Biagioni, AF; Coimbra, NC; de Oliveira, R; de Oliveira, RC; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL; Khan, AU, 2018) |
| "To assess seizure activity, we employed 2 in vivo mouse models of epilepsy, intravenous (iv) pentylenetetrazol (PTZ) and hippocampal electrical kindling, in the presence or absence of Sema4D treatment." | 1.48 | Semaphorin 4D promotes inhibitory synapse formation and suppresses seizures in vivo. ( Acker, DWM; Kang, M; Paradis, S; Wong, I, 2018) |
| "Epilepsy is one of the furthermost common neurodegenerative diseases affecting above 50 million individuals worldwide." | 1.48 | Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy. ( El-Azab, MF; Moustafa, YM; Tawfik, KM, 2018) |
| "TTA-P2 (10 mg/kg) reduced seizure severity in mice undergoing alcohol WD with concurrent PTZ treatment (20 mg/kg)." | 1.48 | Selective Blockade of T-Type Ca2+ Channels is Protective Against Alcohol-Withdrawal Induced Seizure and Mortality. ( Godwin, DW; Masicampo, ML; Shan, HQ; Speagle, M; Xu, V, 2018) |
| "The relationships between seizures, neuronal death, and epilepsy remain one of the most disputed questions in translational neuroscience." | 1.48 | Transient Morphological Alterations in the Hippocampus After Pentylenetetrazole-Induced Seizures in Rats. ( Kim, KK; Lavrentyeva, VV; Lukomskaya, NY; Magazanik, LG; Tumanova, NL; Vasilev, DS; Zaitsev, AV; Zhuravin, IA, 2018) |
| "Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist." | 1.48 | Pentylenetetrazole-Induced Kindling Mouse Model. ( Shimada, T; Yamagata, K, 2018) |
| "Thereafter, the PTZ seizure threshold was measured in control and HFD rats." | 1.48 | The effect of high-fat diet on seizure threshold in rats: Role of oxidative stress. ( Al Yacoub, ON; Alrabadi, N; Alzoubi, KH; Azab, MA; Banihani, SA; Hasan, ZA; Khabour, OF; Mayyas, FA, 2018) |
| "Head-bobbing convulsions were previously reported to be inducible by pentylenetetrazol (PTZ) in C." | 1.48 | A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action. ( Barclay, JW; Burgoyne, RD; Cunliffe, VT; Dodd, S; Grimes, D; Jones, A; Marson, AG; Morgan, A; Sills, GJ; Wong, SQ, 2018) |
| "Seizures are sustained neuronal hyperexcitability in brain that result in loss of consciousness and injury." | 1.48 | Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. ( Han, L; He, Q; Ji, X; Jin, M; Liu, K; Sheng, W, 2018) |
| "These data suggest that convulsive seizures can be obtained in FPI-treated rats when NSS is used as an inclusion criterion to select rats with severe injury." | 1.48 | Convulsive seizures and EEG spikes after lateral fluid-percussion injury in the rat. ( Kelly, W; MacWilliams, Z; Patterson, D; Poulsen, A; Poulsen, D; Rau, T; Smith, D, 2018) |
| "Cunaniol-induced seizures displayed a cyclic development of electrocorticographic seizures, presenting interictal-like spike and ictal period, which correlates to the behavioral observations and is in line with acute seizures induced by pentylenetetrazole." | 1.48 | Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses. ( Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF, 2018) |
| "The current study evaluates the anticonvulsant effect of valproic acid (VPA) alone or combined with low dose γ-irradiation (LDR) against pentylenetetrazol-induced convulsions in rats." | 1.48 | Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway. ( Kenawy, SA; Lotfy, DM; Mohamed, SH; Safar, MM, 2018) |
| "The anti-seizure activities and interactions of selective Sig1R agonist PRE-084, selective Sig1R antagonist NE-100 and novel positive allosteric Sig1R modulator E1R were evaluated in pentylenetetrazol (PTZ) and (+)-bicuculline (BIC)-induced seizure models in mice." | 1.46 | The activity of selective sigma-1 receptor ligands in seizure models in vivo. ( Dambrova, M; Lauberte, L; Misane, I; Stonans, I; Svalbe, B; Vavers, E; Zvejniece, L, 2017) |
| "In six-hertz-seizure test the MeCO (25, 50, 100 and 200mg/kg) and AeCO (50, 100, 200, 400 and 800mg/kg) showed significant protection compared to control group, and MeCO was more potent than AeCO." | 1.46 | Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism. ( Prasad, NBL; Venkataranganna, MV; Viswanatha, GL, 2017) |
| "The duration of generalized convulsions induced by PTZ was not altered." | 1.46 | Anticonvulsant activity of Caryocar coriaceum Wittm. fixed pulp oil against pentylenetetrazol-induced seizures. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Meier, L; Menezes, IRA; Oliveira, CC; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LFF, 2017) |
| "In PTZ - model onset of tonic- clonic seizures, latencies to the beginning of the seizure activity, and mortality, and similarly in audiogenic seizures behavioral convulsive reactions , facial automatisms and latency to wild running were evaluated." | 1.46 | [ANTISEIZURE ACTIVITY OF C EPHALARIA GIGANTEA ROOT EXTRACT]. ( Dekanosidze, G; Gedevanishvili, M; Gogitidze, N; Mushkiashvili, N; Tabatadze, N, 2017) |
| "Seizures are epileptic manifestations that are intrinsically modulated through different neurotransmitters and receptor systems." | 1.46 | Posterior hypothalamus glutamate infusion decreases pentylenetetrazol-induced seizures of male rats through hippocampal histamine increase. ( Arzhang, A; Elahdadi Salmani, M; Goudarzi, I; Lashkarbolouki, T, 2017) |
| "It has been established that febrile seizures and its extended syndromes like generalized epilepsy with febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes." | 1.46 | Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2 ( Kang, JQ; Liu, Z; Macdonald, RL; Warner, TA, 2017) |
| "Recurrent seizures that define epilepsy are often accompanied by psychosocial problems and cognitive deficits with incompletely understood aetiology." | 1.46 | The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space. ( Ahmadi, M; Dufour, JP; Mirnajafi-Zadeh, J; Saab, BJ; Seifritz, E, 2017) |
| " JsAE was assessed in a dose-response manner (30, 100 and 1000mg/kg, i." | 1.46 | Justicia spicigera Schltdl. and kaempferitrin as potential anticonvulsant natural products. ( Aguillón, M; Almazán-Alvarado, S; Domínguez, F; González-Trujano, ME; Martínez, A; Martínez-Vargas, D; Pérez-Ortega, G, 2017) |
| "In the PTZ-induced seizures test, VRB showed anticonvulsant activity at doses of 200 mg/kg i." | 1.46 | Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos. ( Braga, RM; da Fonsêca, DV; de Almeida, RN; de Farias, IEV; de Luna Freire Pessôa, H; de Melo, CGF; de Sousa, DP; do Amaral, IPG; Filho, MRDC; Lima, EM; Salgado, PRR, 2017) |
| "Epilepsy is a chronic neurological condition, with over 30% of cases unresponsive to treatment." | 1.46 | Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy. ( Copmans, D; de Witte, PAM; Hunyadi, B; Siekierska, A; Sourbron, J, 2017) |
| "The onset and duration of seizure were recorded." | 1.46 | Intranasal nerve growth factor attenuating the seizure onset via p75R/Caspase pathway in the experimental epilepsy. ( Duan, Y; Feng, F; Lei, J; Lian, L; Liang, Q; Liu, Z; Wang, F; Xu, F; Zhang, N, 2017) |
| "Most antidepressants lower seizure threshold, which might be due to the modulation of serotonergic neurotransmission." | 1.46 | HBK-14 and HBK-15, triple 5-HT ( Gryboś, A; Nieoczym, D; Pieróg, M; Pytka, K; Rapacz, A; Siwek, A; Socała, K; Waszkielewicz, A; Wlaź, P, 2017) |
| "The intensity of seizures in pretreated mice varied significantly according to circadian stage." | 1.46 | Circadian variation in anticonvulsant activity of valproic acid in mice. ( Aouam, K; Ben-Attia, M; Boughattas, NA; Dridi, I; Khedhaier, WBC; Reinberg, A, 2017) |
| "LCM and LEV were both effective against seizures induced by PTZ." | 1.46 | Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia. ( Alexopoulos, AV; Gonzalez-Martinez, J; Najm, IM; Nemes, AD; O'Dwyer, R; Ying, Z, 2017) |
| " Serum levels of valproate were estimated using HPLC for pharmacokinetic study." | 1.46 | Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate. ( Gupta, YK; Joshi, D; Kaleekal, T; Kumar, R; Sarangi, SC, 2017) |
| "Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction." | 1.46 | Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques. ( Nuñez, A; Reyes-Marin, KE, 2017) |
| "RESV modified brain inflammation during epileptogenesis and found to possess nootropic activity in the kindled mice." | 1.46 | Resveratrol suppressed seizures by attenuating IL-1β, IL1-Ra, IL-6, and TNF-α in the hippocampus and cortex of kindled mice. ( Agarwal, NB; Hoda, U; Parvez, S; Raisuddin, S; Vohora, D, 2017) |
| "3 or 1mg/kg dosage of FTY720, 1h before PTZ injections." | 1.46 | Fingolimod enhances myelin repair of hippocampus in pentylenetetrazol-induced kindling model. ( Ghasemi-Kasman, M; Ghorbanian, D; Gol, M; Hassanzadeh, S; Javan, M; Mirnajafi-Zadeh, J, 2017) |
| "The median seizure stage, latency onset of first stage 4/5 seizures, and incidence of convulsing animals were recorded." | 1.46 | Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms. ( Al-Shorbagy, MY; Nassar, NN, 2017) |
| "Convulsive seizures are due to abnormal synchronous and repetitive neuronal discharges in the central nervous system (CNS)." | 1.46 | SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats. ( Asadi, S; Fereidoni, M; Kordi Jaz, E; Moghimi, A; Roohbakhsh, A; Shamsizadeh, A, 2017) |
| "Epilepsy is a common brain disorder characterized by the occurrence of recurring, unprovoked seizures." | 1.46 | EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors. ( Cai, M; Cai, S; Chen, L; Duan, S; Gu, H; Lin, R; Ling, C; Lu, J; Pan, X; Wang, Y; Zhu, H, 2017) |
| "Crocin treatment at 5, 10 and 20 mg/kg p." | 1.46 | Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation. ( Mazumder, AG; Patial, V; Sharma, P; Singh, D, 2017) |
| "Luteolin was investigated on the course of kindling development and oxidative stress markers [reduced glutathione (GSH) and malondialdehyde (MDA)] in kindled mice." | 1.46 | Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy. ( Jain, P; Patil, A; Sancheti, J; Sathaye, S; Somani, G; Tambe, R, 2017) |
| "Sumatriptan has been used for the acute treatment of migraine attacks." | 1.46 | Sumatriptan, an Antimigraine Drug, Inhibits Pentylenetetrazol-induced Seizures in NMRI Mice. ( Jand, A; Palizvan, MR, 2017) |
| "In spite of recent advances in the treatment of epilepsy, up to 35% of people living with the condition do not respond to accessible anti-epileptic drugs (AEDs) and continue to experience regular, devastating and potentially life-threatening seizures." | 1.46 | Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity. ( Asadi-Shekaari M, M; Esmaeili-Mahani, S; Kalantaripour, TP; Najafipour, H; Sheibani, V, 2017) |
| "In PTZ-induced acute seizures model, behavioral assay showed that chronic metformin treatment decreased the mortality, and LFPs recording showed that chronic metformin treatment shortened the duration of generalized tonic-clonic seizures and prolonged the duration of postictal depression." | 1.46 | Chronic metformin treatment facilitates seizure termination. ( Hu, Y; Li, Y; Wang, X; Yang, Y; Zhang, Y; Zheng, F; Zhu, B, 2017) |
| "Understanding how the brain responds to seizures is important for development of new treatment strategies for epilepsy, a neurological condition characterized by recurrent and unprovoked seizures." | 1.46 | Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain. ( Beattie, CE; Berberoglu, MA; Duy, PQ; Hall, CW, 2017) |
| "Epilepsy is a kind of neurogenic diseases with high prevalence and characterized by seizure, brain paradoxical discharge and convulsion in spontaneous, transient, recurrent and uncontrolled manner." | 1.43 | [Establish and use of an epilepsy model in larval zebrafish]. ( Song, DQ; Tang, S; Zhang, JP; Zheng, YM, 2016) |
| "The different effects of quercetin on seizure threshold may occur through several mechanisms." | 1.43 | Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models. ( Abbasi, E; Hajiali, F; Mohseni, F; Nassiri-Asl, M; Taghiloo, M; Yousefi, F, 2016) |
| "Many drugs have been associated with seizures as a side effect." | 1.43 | Positive effects of ceftriaxone on pentylenetetrazol-induced convulsion model in rats. ( Çavuşoğlu, T; Erbas, O; Özkeşkek, K; Solmaz, V; Tümer, MK; Uyanikgil, Y, 2016) |
| "Treatment with phenytoin per se and along with the flavonoid rich fraction showed significant reduction in seizure severity score as compared to vehicle control." | 1.43 | Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants. ( Goel, RK; Singh, D; Singh, P, 2016) |
| "We examined the anti-seizure effect of TMCA." | 1.43 | 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. ( Chen, CR; Chen, CY; Wei, XD, 2016) |
| "We observed increased latency of tonic-clonic seizures that was inversely proportional to the dose of MRE, with a similar impact on the lethal effects of pentylenetetrazol." | 1.43 | Anticonvulsant activity of methanolic extract from Kalanchoe pinnata Lam. stems and roots in mice: A comparison to diazepam. ( Hernández-Medel, Mdel R; Mora-Pérez, A, 2016) |
| "Using the maximal electroshock seizure (MES) as a model of tonic-clonic generalized seizures, we report that mice treated with TTA-A2 (0." | 1.43 | Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model. ( Chemin, J; Forichon, L; Françon, D; Gangarossa, G; Lerat, B; Lerner-Natoli, M; Lory, P; Sakkaki, S; Valjent, E, 2016) |
| "Taken together, although the seizure threshold is reduced in naive Spry2/4(+/-) mice, neurodegeneration and GCD is mitigated following KA induced hippocampal lesions, identifying Spry proteins as possible pharmacological targets in brain injuries resulting in neurodegeneration." | 1.43 | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. ( Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L, 2016) |
| "Adequate control of seizures remains an unmet need in epilepsy." | 1.43 | Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols. ( Gunia-Krzyżak, A; Koczurkiewicz, P; Marona, H; Nitek, W; Pękala, E; Szkaradek, N; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E, 2016) |
| " Strychnine, an inhibitor of glycine receptor activity, reversed the threshold elevation at a subconvulsive dosage (0." | 1.43 | A Highly Selective Inhibitor of Glycine Transporter-1 Elevates the Threshold for Maximal Electroshock-Induced Tonic Seizure in Mice. ( Cai, Y; Cheng, W; Cui, L; Li, K; Liang, G; Tao, H; Xian, W; Yin, M; Zhao, B; Zhao, J, 2016) |
| "Pretreatment by flumazenil could inhibit the effect of Citrullus colocynthis on latency of seizure to some extent and administration of naloxone significantly inhibited changes in latency and duration of seizure produced by Citrullus colocynthis This study showed that Citrullus colocynthis has significant anticonvulsant effect in pentylenetetrazole-induced seizures in mice, and these effects may be related to its effect on γ-aminobutyric acid-ergic and opioid systems." | 1.43 | Anticonvulsant Activity of Hydroalcoholic Extract of Citrullus colocynthis Fruit: Involvement of Benzodiazepine and Opioid Receptors. ( Mehrzadi, S; Motevalian, M; Pur, SA; Shojaii, A, 2016) |
| "Chloroquine has long been used for the treatment of malaria and rheumatological disorders." | 1.43 | Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016) |
| "The threshold for seizure induction with progressive intravenous infusion of pentylenetrazole (PTZ) was evaluated in anesthetized Wistar rats after a ten-day oral administration of BD-AcAc2 (gavage)." | 1.43 | Different calorie restriction treatments have similar anti-seizure efficacy. ( Arnold, P; Coppola, G; D'Agostino, D; Monda, M; Pilla, R; Viggiano, A; Zeppa, P, 2016) |
| "During ongoing SW seizures, SCS was conducted at 30, 80, 130, and 180 Hz and VNS at 10, 30, 80, 130, and 180 Hz." | 1.43 | The Influence of Vagus Nerve and Spinal Cord Stimulation on the Ictal Fast Ripple Activity in a Spike-and-Wave Rat Model of Seizures. ( Harreby, KR; Jensen, W; Jiao, J; Sevcencu, C; Yang, X, 2016) |
| "Spontaneous seizures were not detected more often in APParc mice than in their wild-type control mice." | 1.43 | Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease. ( Graff, C; Gurevicius, K; Miszczuk, D; Pitkänen, A; Rönnbäck, A; Tanila, H; Winblad, B; Ziyatdinova, S, 2016) |
| "In this study, three seizure models, including intravenous pentylenetetrazole (PTZ), intraperitoneal PTZ and electroshock, were examined in mice." | 1.43 | The interaction between morphine and propranolol in chemical and electrical seizure models of mice. ( Fakhrzad, A; Khosravani, E; Moezi, L; Shafaroodi, H, 2016) |
| "PTZ) seizure test, the maximal electroshock seizure threshold (MEST) test and the 6 Hz seizure test were used in the present study." | 1.43 | SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice. ( Socała, K; Szuster-Ciesielska, A; Wlaź, P, 2016) |
| "BPPU also successfully inhibited seizures induced by 3-mercaptopropionic acid (3-MPA) and thiosemicarbazide (TSC) in mice thus, suggested that BPPU might influence GABA-ergic neurotransmission in the brain." | 1.43 | Pharmacological evaluation of novel 1-[4-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent. ( Kumari, S; Mishra, CB; Tiwari, M, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Seizures were induced in rats by daily injection of PTZ for 36 days." | 1.43 | Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling. ( Chang, YN; Fu, T; Liu, JQ; Qu, ZZ; Wang, WP; Zhen, JL, 2016) |
| "Vigabatrin is a clinically approved anti-seizure drug, which acts by increasing brain GABA levels by irreversibly inhibiting GABA-aminotransferase (GABA-T)." | 1.43 | Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models. ( Gernert, M; Gey, L; Löscher, W, 2016) |
| "Neonatal or early-life seizures (ELS) are often associated with life-long neurophysiological, cognitive and behavioral deficits, but the underlying mechanisms contributing to these deficits remain poorly understood." | 1.43 | Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons. ( Atkinson, EW; Coleman, JE; Hoang-Minh, LB; Le, MM; Parker, AK; Sarkisian, MR; Semple-Rowland, S; Smith, TS; Ugartemendia, G, 2016) |
| "Effects on seizure threshold and locomotion were studied using C57BL/6N mice and compared with saline-treated controls." | 1.43 | Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives. ( Haider, M; Hering, S; Hintersteiner, J; Khom, S; Luger, D; Mihovilovic, MD; Pototschnig, G; Schwarzer, C, 2016) |
| "The Pentylenetetrazole-induced seizure was used as a standard convulsion model in this study." | 1.43 | Oxytocin is involved in the proconvulsant effects of Sildenafil: Possible role of CREB. ( Dehpour, AR; Ejtemaei Mehr, S; Fakhfouri, G; Khodagholi, F; Khoshneviszadeh, M; Payandemehr, B; Rahimian, R, 2016) |
| "Firstly, seizure latency induced by pentylenetetrazole was significantly prolonged 6 weeks after brain injury in group of SR141716A treatment." | 1.43 | CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus. ( Liu, C; Wang, X; Wang, Y; Wei, N; Zhang, C; Zhang, JG; Zhang, K; Zhao, B, 2016) |
| "The ketogenic diet (KD) controls seizure and improves cognition in patients with drug refractory epilepsy." | 1.43 | Ketogenic diet attenuates spatial and item memory impairment in pentylenetetrazol-kindled rats. ( Hou, Q; Jia, M; Jiang, Y; Lu, Y; Wang, B; Wang, X; Zhang, Z, 2016) |
| "The mechanism responsible for the anti-seizure effect of ketogenic diets is poorly understood." | 1.43 | Ketogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats. ( Coppola, G; Iovane, V; Monda, M; Operto, FF; Pisano, S; Stoddard, M; Viggiano, A, 2016) |
| "Stress is a trigger factor for seizure initiation which activates hypothalamic pituitary adrenal (HPA) axis as well other brain areas." | 1.43 | Lateral hypothalamus orexinergic system modulates the stress effect on pentylenetetrazol induced seizures through corticotropin releasing hormone receptor type 1. ( Abrari, K; Elahdadi Salmani, M; Goudarzi, I; Lashkarbolouki, T; Mokhtarpour, M, 2016) |
| "Racine convulsion scores, first myoclonic jerk time, spike percentages, and antioxidant status were evaluated in the groups." | 1.43 | Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures. ( Çavuşoğlu, T; Çetin, EÖ; Çınar, BP; Erbaş, O; Solmaz, V; Sur, HY; Uyanıkgil, Y, 2016) |
| "Rosmarinic acid is a naturally occurring substance which displays several biological effects including antioxidant and neuroprotective activity." | 1.43 | Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice. ( Freitas, ML; Furian, AF; Grauncke, AC; Grigoletto, J; Oliveira, CV; Oliveira, MS; Santos, AR; Souto, NS; Souza, TL, 2016) |
| "They inhibited induction of convulsion and gave 100% protections against mortality." | 1.43 | Anticonvulsant activities of Sambucus nigra. ( Ataee, R; Ebrahimzadeh, MA; Falahati, A; Shokrzadeh, M, 2016) |
| "Seizures were recorded inside the open field apparatus for an average of 10min." | 1.43 | Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception. ( Biagioni, AF; Coimbra, NC; de Oliveira, R; de Oliveira, RC; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL, 2016) |
| "Seizures were detected in real time from cortical local field potentials, after which DCS was applied." | 1.43 | A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. ( Guggenmos, D; Lebedev, M; Moreira, D; Nicolelis, MAL; Pais-Vieira, M; Santos, A; Yadav, AP, 2016) |
| "Rats were observed for 30min and the seizure severity behavior measured using a modified Racine's scale." | 1.43 | The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats. ( de Carvalho, CR; Franco, PL; Hoeller, AA; Lin, K; Martini, AP; Prediger, RD; Soares, FM; Walz, R; Whalley, BJ, 2016) |
| "In Akt1(-/-) and wild-type mice, seizures induced using pentylenetetrazol (a GABAAR antagonist) were measured, and GABAAR expression and GABAergic interneuron abundance in the brain were examined." | 1.43 | Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions. ( Chang, CY; Chen, YW; Lai, WS; Wang, TW, 2016) |
| "During this time, the occurrence of seizures and death was recorded." | 1.43 | Structure-activity relationship for the anticonvulsant effects of organic solvents. ( Cruz, SL; Gauthereau-Torres, MY; Rivera-García, MT, 2016) |
| "Behavioral scoring was used to access seizure." | 1.43 | Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. ( Asadi-Shekaari, M; Esmaeili-Mahani, S; Kalantaripour, TP; Pasban-Aliabadi, H; Sheibani, V, 2016) |
| "A prominent, seizure intensity-dependent increase of Nav1." | 1.43 | Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis. ( Ji, Y; Jiang, N; Jin, J; Lin, W; Wang, Z; Wu, H; Zhao, Y; Zhu, H, 2016) |
| "Finally, using multiple in vivo seizure models, we identify potent lead candidates for the treatment of epilepsy." | 1.42 | Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. ( Cano-Jaimez, M; Chang, P; Close, AJ; McEvoy, JP; Spencer, J; Walker, MC; Williams, RS; Williams, S; Zuckermann, AM, 2015) |
| "The enhanced seizure susceptibility of the NaV1." | 1.42 | 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour. ( Aumann, TD; Churilov, L; Featherby, TJ; Gazina, EV; Hammond, VE; Kim, TH; Leaw, BT; Petrou, S; Reid, CA; Richards, KL; Wimmer, VC, 2015) |
| "Diazepam was used as reference anticonvulsant drug." | 1.42 | Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed. ( FallahHuseini, H; Ghaznavi, H; Gholamine, B; Hosseinzadeh, A; Mehrzadi, S; Sadr, S; Shahbazi, A, 2015) |
| "However, preclinical seizure experiments need to be conducted in awake animals with images reconstructed and displayed in real-time." | 1.42 | Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography. ( Carney, PR; Jiang, H; Zhang, T; Zhou, J, 2015) |
| "Pretreatment with pioglitazone, as a PPARγ agonist, potentiated the anticonvulsant effects of WIN, while PPARγ antagonist inhibited these anticonvulsant effects partially." | 1.42 | Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2. ( Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B, 2015) |
| "PTZ-induced generalized tonic-clonic seizures were suppressed in 18- and 25-day-old rats by 10 and 20mg/kg doses of IEM1460." | 1.42 | An antagonist of calcium permeable AMPA receptors, IEM1460: Anticonvulsant action in immature rats? ( Mareš, P; Szczurowska, E, 2015) |
| "In contrast, seizures between P20 and P30 did not result in cerebral atrophy or significant imaging abnormalities in the hippocampus or white matter, but irreversibly decreased PPI in the DG compared to normal adult controls." | 1.42 | Age-dependent long-term structural and functional effects of early-life seizures: evidence for a hippocampal critical period influencing plasticity in adulthood. ( Hutchinson, E; Meyerand, ME; Sayin, U; Sutula, T, 2015) |
| "Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties." | 1.42 | Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish. ( Bogo, MR; Bonan, CD; Capiotti, KM; da Costa Schaefer, I; Da Silva, RS; Frantz, JZ; Kist, LW; Menezes, FP; Siebel, AM, 2015) |
| "Moreover, the latency of seizure development was elevated under these conditions." | 1.42 | Increase of the seizure threshold in C57BL/6 mice after citicoline administration. ( Karpova, MN; Klishina, NV; Kuznetsova, LV; Zin'kovskii, KA, 2015) |
| "PTZ-kindled mice showed high seizure activity, hippocampal neuronal loss, and expression of growth-associated phosphoprotein (GAP-43) compared with saline-treated mice." | 1.42 | Fluvoxamine alleviates seizure activity and downregulates hippocampal GAP-43 expression in pentylenetetrazole-kindled mice: role of 5-HT3 receptors. ( Alhaj, MW; Moustafa, YM; Zaitone, SA, 2015) |
| " Susceptibility to absence seizures was examined by analysing the frequency and duration of spike-and-wave discharge (SWD) events and accompanying motor seizure activity induced by subcutaneous administration of low dosage (20 or 30mg/kg) PTZ." | 1.42 | Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism. ( Anderson, P; Argyropoulos, A; Hannan, AJ; Hill-Yardin, EL; Hosie, S; O'Brien, TJ; Rind, G, 2015) |
| "Behavioral convulsions were provoked by intravenous pentylenetetrazol (PTZ) application model." | 1.42 | Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats. ( Elahdadi Salmani, M; Goudarzi, E; Goudarzi, I; Lashkarbolouki, T, 2015) |
| "apodanthera showed dose-dependent antiseizure effects." | 1.42 | Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice. ( Ayissi, ER; Kandeda, AK; Kouemou, N; Moto, FC; Ngo Bum, E; Ngoupaye, GT; Njapdounke, JS; Nkantchoua, GC; Omam, JP; Pahaye, D; Pale, S; Taiwe, GS, 2015) |
| "Seizures are a known co-occurring symptom of Alzheimer's disease, and they can accelerate cognitive and neuropathological dysfunction." | 1.42 | Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. ( Harrison, FE; Kang, JQ; Kennard, JA; Warner, TA, 2015) |
| "FP ameliorates seizure severity, cognitive deficits and neuronal cell loss in PTZ kindled mice." | 1.42 | Methanol extract of Ficus platyphylla ameliorates seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice. ( Becker, A; Chindo, BA; Schröder, H, 2015) |
| "Pentylenetetrazole-induced seizures, in contrast, were not able to change Homer1a mRNA expression." | 1.42 | Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures. ( Blanco, MM; Cavarsan, CF; Matsuo, A; Mello, LE, 2015) |
| "Constipation is a common gastrointestinal disorder characterized by symptoms such as straining, hard stool, and infrequent defecation." | 1.42 | Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. ( Inaloo, S; Moezi, L; Pirsalami, F, 2015) |
| "In two chemically induced seizure models, mice with reduced Homerb/c protein had less severe seizures than control mice." | 1.42 | Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling. ( Cao, L; Di, ZL; Jiang, Y; Lei, H; Tian, Y; Zhang, GJ, 2015) |
| "Observed adverse effects differed between CsA treatment regimens and included reversible diarrhea, lowered body temperature, and tremor, the latter two of which were also induced by vehicle injections containing ethanol and/or polyethoxylated castor oil." | 1.42 | Different preparations, doses, and treatment regimens of cyclosporine A cause adverse effects but no robust changes in seizure thresholds in rats. ( Elger, DA; Gernert, M; Gey, L; Handreck, A; Mall, EM, 2015) |
| "Convulsions were induced by pentylenetetrazole, N-methyl-D-aspartate, and by kainic acid." | 1.42 | Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§. ( Anderson, WH; Bui, HH; Falcone, JF; Gleason, SD; Kato, A; Kuo, MS; Li, X; Stutz, PV; Thompson, LK; Valli, SN; Witkin, JM, 2015) |
| "The results indicate that cardiac arrest did not modify the threshold for electroconvulsions either one or two months, following the surgery." | 1.42 | Seizure susceptibility to electroconvulsions or pentylenetetrazol after complete cerebral ischemia in rats due to cardiac arrest. ( Andres-Mach, M; Czuczwar, SJ; Dudra-Jastrzębska, M; Januszewski, S; Pluta, R; Ułamek-Kozioł, M; Łuszczki, JJ, 2015) |
| "Aripiprazole is a novel atypical antipsychotic." | 1.42 | The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "The latency time and tonic—clonic seizure time were registered." | 1.42 | Vitis labrusca leaf extract prevents pentylenetetrazol-induced oxidative damage but not seizures in rats. ( Coitinho, AS; da Costa, BM; Dani, C; Dos Santos, MT; Fank, B; Hackmann, CL; Salvador, M, 2015) |
| "The threshold for seizure induction with progressive intravenous infusion of pentylenetrazole (PTZ) was evaluated in anesthetized Wistar rats two hours after a single 1 ml intragastric administration of BD-AcAc2 (i." | 1.42 | Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure. ( Arnold, P; Coppola, G; D'Agostino, D; Monda, M; Pilla, R; Viggiano, A, 2015) |
| "Aripiprazole is an antipsychotic drug which acts through dopamine and serotonin receptors." | 1.42 | The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Levetiracetam (LEV) is a unique, effective, relatively safe antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 1.42 | Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats. ( Abdel-Wahab, BA; Habeeb, SM; Khateeb, MM; Shaikh, IA, 2015) |
| " administration, however, the dose-response relationship for DHA has shown an inverted U-pattern." | 1.42 | Intravenous infusion of docosahexaenoic acid increases serum concentrations in a dose-dependent manner and increases seizure latency in the maximal PTZ model. ( Bazinet, RP; Burnham, WM; Chen, CT; Domenichiello, AF; Kwong, KM; Trépanier, MO, 2015) |
| "Because oxidative stress and seizures are intimately linked, this study investigated the potential neuroprotective and anticonvulsant effects of commercial clarified açai juice (EO)." | 1.42 | Anticonvulsant properties of Euterpe oleracea in mice. ( Arrifano, GP; Costa-Malaquias, A; Crespo-López, ME; da Silva, RF; de Oliveira, DL; do Nascimento, JL; Hamoy, M; Mendonça, JR; Monteiro, WS; Paraense, RS; Rogez, H; Santana-Coelho, D; Souza-Monteiro, JR, 2015) |
| " Chronic administration of PTZ at 40mg/kg resulted in kindling seizure development." | 1.42 | Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice. ( Ago, Y; Hasebe, S; Hashimoto, H; Inoue, A; Kawanai, T; Matsuda, T; Ooi, Y; Takuma, K; Taruta, A; Watanabe, R, 2015) |
| "We found that the increased seizure susceptibility in the TSP1 knockout (KO) mice was not due to a compensatory increase in TSP2 mRNA as TSP1/2 KO mice were sensitive to PTZ, similar to the TSP1 KO mice." | 1.42 | Increased sensitivity to kindling in mice lacking TSP1. ( Mendus, D; Mustapha, M; Porter, BE; Rankin-Gee, EK, 2015) |
| "Latency to induce seizure, seizure stages and latency and duration of fifth stage of seizure was recorded for each animal." | 1.42 | Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors. ( Aghaei, I; Babaei, P; Khakpour-Taleghani, B; Motamedi, F; Naderi, N; Rostampour, M; Shabani, M, 2015) |
| "Seizures were assessed by video observation of each animal and the electroencephalogram by an automated seizure detection programme." | 1.42 | Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model. ( Bartram, J; Hashemi, K; Lang, B; Stasiak, L; Upton, AL; Vincent, A; Wright, S, 2015) |
| "Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission." | 1.42 | Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery. ( Çengelli Ünel, Ç; Erol, K; Kırımlıoğlu, GY; Yazan, Y, 2015) |
| "In the maximal electroshock-induced seizures (MES) test, prevention of tonic seizures was also verified for all of the isomers tested." | 1.42 | Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers. ( Andrade, LN; Braga, RM; da Fonsêca, DV; de Almeida, RN; de Melo, CG; de Sousa, DP; Salgado, PR, 2015) |
| " Moreover, its use is less toxic and safer." | 1.42 | Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine. ( Gmiro, VE; Serdyuk, SE; Veselkina, OS, 2015) |
| "Sleep deprivation has been shown to be an activator of seizures in clinical and animal studies." | 1.40 | Pentylenetetrazol-induced seizures are exacerbated by sleep deprivation through orexin receptor-mediated hippocampal cell proliferation. ( Liu, XM; Ni, LY; Song, Y; Tang, JY; Zhu, MJ, 2014) |
| "The identification of epileptic seizure-induced alterations on the brain related to their pathologies may provide information for its action mechanism." | 1.40 | Investigation of compositional, structural, and dynamical changes of pentylenetetrazol-induced seizures on a rat brain by FT-IR spectroscopy. ( Ilbay, G; Severcan, F; Severcan, M; Turker, S, 2014) |
| "Erythropoietin (EPO) suppresses epileptic seizures, but the mechanism is unclear." | 1.40 | Erythropoietin pretreatment suppresses seizures and prevents the increase in inflammatory mediators during pentylenetetrazole-induced generalized seizures. ( Akgün-Dar, K; Albeniz, I; Bahçekapılı, N; Kandil, A; Kapucu, A; Üzüm, G; Yağız, O, 2014) |
| "Latency and probability of PTZ-induced seizures were shorter and higher respectively, in hyperthermia-treated animals compared to controls." | 1.40 | Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat. ( Abdeen, Z; Al Shawaaf, F; Al-Ansari, S; Alsaffar, Y; Hassan, Z; Kamal, A; Mandeel, M; Rajab, E, 2014) |
| "Body weight was significantly higher in morphine groups than saline treated rats." | 1.40 | Effect of prenatal forced-swim stress and morphine co-administration on pentylentetrazol-induced epileptic behaviors in infant and prepubertal rats. ( Ebrahimi, L; Hashemi, P; Roshan-Milani, S; Saboory, E, 2014) |
| "Hydrogen sulfide (H2 S) is a gas transmitter that may mediate cerebral ischemic injury." | 1.40 | Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability. ( Chen, JG; Guan, XL; He, JG; Hu, ZL; Luo, Y; Wang, F; Wu, PF; Xiao, W; Zhang, JT; Zhou, J, 2014) |
| "Pentylenetetrazol (PTZ)-induced convulsion test was used to study the anticonvulsant effect of standardized bark extract of F." | 1.40 | Revealing pharmacodynamics of medicinal plants using in silico approach: a case study with wet lab validation. ( Gawande, DY; Goel, RK; Poroikov, V; Singh, D; Singh, T, 2014) |
| "Eclampsia is a poorly understood but potentially fatal complication of pregnancy." | 1.40 | Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments. ( Brennecke, SP; Di, X; Hu, B; Huang, Q; Liu, H; Liu, L, 2014) |
| "Our study supports the concept of seizure-related modifications in brain cytokine production during epileptogenesis." | 1.40 | The role of interleukin-1β in the pentylenetetrazole-induced kindling of seizures, in the rat hippocampus. ( Kołosowska, K; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D, 2014) |
| "On day 15, one subset of animals was seizure tested in the maximal PTZ model (Experiment 1)." | 1.40 | Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model. ( Bazinet, RP; Burnham, WM; Chen, CT; Cho, HJ; Domenichiello, AF; Lai, TK; Lim, J; Taha, AY; Trépanier, MO, 2014) |
| "Valerenic acid (VA) is a β2/3 subunit-specific modulator of γ-aminobutyric acid (GABA) type A (GABAA) receptors inducing anxiolysis." | 1.40 | Esters of valerenic acid as potential prodrugs. ( Haider, M; Hering, S; Hintersteiner, J; Jäger, W; Khom, S; Luger, D; Mihovilovic, MD; Reznicek, G; Schwarzer, C, 2014) |
| "Firstly, seizure latency was significantly prolonged by a 5-HT3 receptor agonist SR 57227 in a dose-dependent manner." | 1.40 | The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice. ( Cui, R; Dong, X; Li, B; Liu, C; Lv, J; Shao, D; Song, Y; Sun, Z; Wang, L; Wang, P; Zhang, X; Zhao, J; Zhou, Y, 2014) |
| "Thalidomide is an old glutamic acid derivative which was initially used as a sedative medication but withdrawn from the market due to the high incidence of teratogenicity." | 1.40 | Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice. ( Ahmadi-Dastgerdi, M; Amanlou, M; Aminizade, M; Bahremand, A; Berijani, S; Dehpour, AR; Dianati, V; Gholizadeh, R; Gooshe, M; Payandemehr, B; Rahimian, R; Sarreshte-Dari, A, 2014) |
| "Metformin was injected intraperitoneally in dose of 200mg/kg along with alternate-day PTZ." | 1.40 | Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. ( Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR, 2014) |
| "Pretreatment with ifenprodil resulted in an anticonvulsant effect in 15-day-old rats only, on the contrary, proconvulsant action was found in 18- and 25-day-old animals (decrease of thresholds especially for transition into the second, limbic type of ADs and increase in duration of ADs)." | 1.40 | Age and activation determines the anticonvulsant effect of ifenprodil in rats. ( Mareš, P, 2014) |
| "We have reported significantly higher convulsion prevalence in patients treated with cefepime than in those treated with meropenem." | 1.40 | Convulsive liability of cefepime and meropenem in normal and corneal kindled mice. ( Araki, H; Suemaru, K; Takechi, K; Tanaka, A; Tanaka, M; Watanabe, S, 2014) |
| "Although epilepsy is a common neurological disorder, its mechanism(s) are still not completely understood." | 1.40 | Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models. ( Chen, L; Chen, Y; Jiang, G; Li, J; Li, Z; Wang, X; Wang, Z, 2014) |
| "Seizures were induced by a daily intraperitoneal (i." | 1.40 | Effects of grape seed proanthocyanidin extract on pentylenetetrazole-induced kindling and associated cognitive impairment in rats. ( Fang, H; Fu, L; Qu, Z; Wang, H; Wang, W; Wu, Y; Zang, H; Zhen, J, 2014) |
| "The maximal electroshock-induced seizure (MES) and pentetrazole (PTZ)-induced seizure models in mice were performed." | 1.40 | Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives. ( Bednarski, M; Dudek, M; Filipek, B; Kulig, K; Kusak, A; Malawska, B; Nowak, G; Sapa, J; Zygmunt, M, 2014) |
| " ABHD6 blockade retained its antiepileptic activity over chronic dosing and was not associated with psychomotor or cognitive effects." | 1.40 | ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. ( Blankman, JL; Cao, JK; Cheah, CS; Cherry, AE; Cravatt, BF; Fung, S; Horne, EA; Hsu, KL; Li, W; Marrs, W; Naydenov, AV; Oakley, JC; Saporito, MS; Selley, DE; Stella, N; Swinney, K; Tu, S; Wen, A, 2014) |
| "Muscimol was administered in doses from 0." | 1.40 | Anticonvulsant and behavioral effects of muscimol in immature rats. ( Mareš, P; Mikulecká, A; Tichá, K, 2014) |
| "Kainate-induced seizures are accompanied by leukotriene formation, and are reduced by inhibitors of LOX/COX pathway." | 1.40 | Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. ( Arroyo, DS; Iribarren, P; Jesse, AC; Lenz, QF; Marafiga, JR; Masson, CJ; Mello, CF; Poersch, AB; Reschke, CR; Temp, FR, 2014) |
| "torvum leaves is used to treat epileptic seizures." | 1.40 | Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum. ( Bock, M; Buenafe, OE; Challal, S; Crawford, AD; Dayrit, FM; de Witte, PA; Esguerra, CV; Harvey, AL; Kloeti, W; Lerche, H; Maljevic, S; Marcourt, L; Queiroz, EF; Wolfender, JL, 2014) |
| "Here, we hypothesized severe preeclampsia is a state of increased seizure susceptibility due to blood-brain barrier (BBB) disruption and neuroinflammation that lowers seizure threshold." | 1.40 | Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. ( Chan, SL; Cipolla, MJ; Johnson, AC; LaMarca, B; Moseley, J; Nagle, KJ; Tremble, SM, 2014) |
| "Naringin is a bioflavonoid present in the grapefruit." | 1.40 | Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection. ( Arya, DS; Bhatia, J; Chaudhry, U; Golechha, M; Saluja, D; Sarangal, V, 2014) |
| " The combined oral chronic administration of phenylephrine in threshold, noneffective alone dose of 0." | 1.40 | [Stimulation of gastric mucosa afferents by phenylephrine potentiates anticonvulsive and eliminates sedative action of sodium valproate in the pentylenetetrazol kindling model in rats]. ( Gmiro, VE; Serdiuk, SE; Veselkina, OS, 2014) |
| "Perinatal stroke is a common cerebrovascular disorder affecting 1 in every 4000 births; typically associated with epilepsy." | 1.39 | Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7. ( Brima, T; Mareš, P; Otáhal, J, 2013) |
| "Idiopathic epilepsy is characterized by seizures without a clear etiology and is believed to have a strong genetic component but exhibits a complex inheritance pattern." | 1.39 | Down-regulation of RalBP1 expression reduces seizure threshold and synaptic inhibition in mice. ( Bae, YS; Chung, W; Han, K; Kim, E; Kim, H; Kim, MH; Park, KY, 2013) |
| "Pentylenetetrazole effectiveness was dependent on the time of treatment; cognitive performance improved after treatment during the light (inactive) phase, but not during the dark (active) phase." | 1.39 | Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome. ( Blank, M; Buckmaster, P; Chuluun, B; Colas, D; Garner, CC; Heller, HC; Warrier, D; Wetmore, DZ, 2013) |
| "Rats with repetitive PTZ-induced seizures demonstrated lower phenytoin-induced anticonvulsant effects, increased number of DiBAC4(3) fluorescence cells and P-gp overexpression in hippocampus and neocortex, as well as augmentation of the induced fEPSP in CA1 field." | 1.39 | P-glycoprotein contributes to cell membrane depolarization of hippocampus and neocortex in a model of repetitive seizures induced by pentylenetetrazole in rats. ( Auzmendi, JA; Bañuelos-Cabrera, I; Calixto González, E; González-Trujano, ME; Lazarowski, A; Orozco-Suárez, S; Rocha, L, 2013) |
| "During the follow-up study, the seizure severity increased in animals treated with 0." | 1.39 | Effect of different frequencies of repetitive transcranial magnetic stimulation on acquisition of chemical kindled seizures in rats. ( Firoozabadi, SM; Javan, M; Mirnajafi-Zadeh, J; Mongabadi, S; Shojaei, A, 2013) |
| "Seizures were analyzed using the Lamberty & Klitgaard score and kindling was considered as established after at least three consecutive seizures of score 4 or 5." | 1.39 | Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats. ( Beleboni, RO; Cunha, AO; Dos Santos, WF; Gelfuso, EA; Liberato, JL; Lopes, NP; Mortari, MR, 2013) |
| "A chronic kindling seizures rat model was established by intraperitoneal injecting pentylenetetrazol (PTZ)." | 1.39 | [Effects of heterotherapy for homopathy on the metabolism path of glutamate in the pentylenetetrazol-kindled seizure rats' hippocampus]. ( Xie, W; Yu, YH; Zhao, YY, 2013) |
| " However, there is no available report for the effect of chronic administration of Lavandula extract in development (acquisition) of epilepsy." | 1.39 | Anti-epileptogenic and antioxidant effect of Lavandula officinalis aerial part extract against pentylenetetrazol-induced kindling in male mice. ( Ahghari, P; Khalili, M; Rahmati, B; Roghani, M, 2013) |
| "The behavioral signs of kindled seizures were observed for 20 min after each PTZ injection." | 1.39 | Comparison between standard protocol and a novel window protocol for induction of pentylenetetrazol kindled seizures in the rat. ( Davoudi, M; Javan, M; Mirnajafi-Zadeh, J; Palizvan, MR; Shojaei, A, 2013) |
| "In the PTZ-induced seizure model, i." | 1.39 | The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice. ( Ahmad-Molaei, L; Motamedi, F; Naderi, N; Shirazi-zand, Z, 2013) |
| "Agmatine also potentiates the anti-seizure activity of morphine." | 1.39 | Role of nitric oxide in additive anticonvulsant effects of agmatine and morphine. ( Bahremand, A; Dehpour, AR; Derakhshanian, H; Ebrahimi, A; Fadakar, K; Moghaddas, P; Payandemehr, B; Rahimian, R; Saadat, S, 2013) |
| "Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together." | 1.39 | Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. ( Augustin, I; Begemann, M; Brose, N; Ehrenreich, H; Gurvich, A; Ju, A; Man, KN; Müller-Ribbe, K; Papiol, S; Ronnenberg, A; Shin, Y; Stepniak, B; Tantra, M; Wojcik, SM, 2013) |
| "Pretreatment with clonidine (0." | 1.39 | The role of α₂-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice. ( Bahremand, A; Dehpour, AR; Moezi, L; Shafaroodi, H, 2013) |
| "In the pilocarpine-induced seizure model, all dosages of agomelatine or melatonin showed a significant decrease in TBARS levels and nitrite content in all brain areas when compared to controls." | 1.39 | Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. ( Aguiar, CC; Almeida, AB; Araújo, PV; Chaves, EM; de Barros Viana, GS; do Vale, OC; Leal, LK; Macêdo, DS; Vasconcelos, GS; Vasconcelos, SM, 2013) |
| "The incidence of seizures, their expression pattern and their latencies were registered and the severity was expressed by means of a five-point scale." | 1.39 | Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. ( Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B, 2013) |
| " Luteolin did not exhibit any consistent anti- or pro-convulsant actions after single dosing in the 6 Hz (0." | 1.39 | Anticonvulsant screening of luteolin in four mouse seizure models. ( Borges, K; Shaikh, MF; Tan, KN, 2013) |
| "Diazepam-induced sleep was used for the evaluation of the sedative properties." | 1.39 | The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice. ( Moto, FC; Ngah, E; Ngo Bum, E; Ngoupaye, GT; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS; Talla, E, 2013) |
| "Hypericum (H." | 1.39 | Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved. ( Ahangar, N; Ebrahimzadeh, MA; Nabavi, SF; Nabavi, SM, 2013) |
| "In two chemically induced seizure models, mice with reduced tau protein had less severe seizures than control mice." | 1.39 | Antisense reduction of tau in adult mice protects against seizures. ( Bennett, CF; Chen, G; Cirrito, JR; DeVos, SL; Goncharoff, DK; Holtzman, DM; Kebodeaux, CS; Maloney, SE; Miller, TM; Rigo, F; Schuler, DR; Stewart, FR; Wozniak, DF; Yamada, K, 2013) |
| "Handling-evoked and spontaneous convulsive seizures were observed in many BoNT/B-treated animals but not in vehicle-treated controls." | 1.39 | Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat. ( Bröer, S; Gernert, M; Rogawski, MA; Zolkowska, D, 2013) |
| "Piperine could activate transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor, and the rapid activation of whole-cell currents is antagonized by the competitive TRPV1 antagonist capsazepine." | 1.39 | Piperine exerts anti-seizure effects via the TRPV1 receptor in mice. ( Chen, CR; Chen, CY; Li, W; Qu, KP, 2013) |
| "In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i." | 1.39 | Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ( Buenafe, OE; Crawford, AD; De Borggraeve, W; de Witte, P; Esguerra, CV; Huang, H; Luyten, W; Maes, J; Orellana-Paucar, A; Ying, X, 2013) |
| "Recently, seizures in dogs have been proposed as a translational platform for human therapeutic trials on new epilepsy treatments." | 1.39 | The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs. ( Hoffmann, K; Löscher, W; Potschka, H; Töllner, K; Twele, F, 2013) |
| "FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice." | 1.39 | Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice. ( Cui, R; Li, B; Li, Y; Liu, L; Song, Y; Tang, F; Wang, L; Wang, Y; Zhao, J; Zhou, Y, 2013) |
| "We tested adult male rats for seizures evoked by pentylenetetrazole (70 mg/kg) between 3 and 20 days following placement of bilateral craniotomies (either 2." | 1.39 | Delayed effect of craniotomy on experimental seizures in rats. ( Forcelli, PA; Gale, K; Kalikhman, D, 2013) |
| "Peroral chronic administration the standard antiepileptic drug sodium valproate in a dose of 200 mg/kg eliminates development of generalized clonic-tonic pentylenetetrazol kindling seizures in 100% of rats, but only in 57% of rats this treatment prevents clonic kindling seizures." | 1.39 | [Combined blockade of AMPA- and NMDA-receptors has maximum effect to eliminate development of pentylenetetrazole-induced kindling in rats]. ( Gmiro, VE; Serdiuk, SE; Veselkina, OS, 2013) |
| "Atorvastatin has shown to possess neuroprotective, antiexcitotoxic, and antiepileptic effects besides its cholesterol-lowering properties." | 1.39 | Anticonvulsive effect of atorvastatin on pentylenetetrazole-induced seizures in mice: the role of nitric oxide pathway. ( Emamzadeh-Fard, S; Moazzami, K; Shabani, M, 2013) |
| "Our findings indicated that PTZ-induced seizure showed not only decrease in GABABR expression but also cause neuronal apoptosis in the developing rat brain." | 1.39 | Decreased GABABR expression and increased neuronal cell death in developing rat brain after PTZ-induced seizure. ( Al-Qahtani, MH; Ansari, SA; Bibi, F; Karim, S; Kim, MO; Naseer, MI; Ullah, I; Ullah, N, 2013) |
| "Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex." | 1.39 | Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish. ( Beattie, CE; Hall, CW; Pineda, R, 2013) |
| "In the remaining animals that exhibited seizures, KB-R7943 (3 mg/kg; p." | 1.39 | Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats. ( N'Gouemo, P, 2013) |
| "The activity of these compounds on seizure control is independent of histone deacetylase inhibitory activity (associated with the teratogenicity of VPA), and does not correlate with liver cell toxicity." | 1.39 | Seizure control by ketogenic diet-associated medium chain fatty acids. ( Chang, P; Chen, PE; Plant, N; Terbach, N; Walker, MC; Williams, RS, 2013) |
| "Evans blue was used as BBB tracer." | 1.39 | The effects of zinc treatment on the blood-brain barrier permeability and brain element levels during convulsions. ( Demir, G; Oztaş, B; Seker, FB; Yalçın, IE; Yorulmaz, H, 2013) |
| "We examined the seizure susceptibility of these mice to determine if the presence (BXD29-Trl4(lps-2J)/J) or absence (C57BL/10J) of p-ACC, in strains with MCD, confers a differential response to chemi-convulsive treatment." | 1.39 | Differential seizure response in two models of cortical heterotopia. ( Gabel, LA; Ibanez, N; Manglani, M; Ramos, RL; Roberts, J; Rosen, GD, 2013) |
| "In the animal seizure models tested, the anticonvulsant profile of indazole most resembled that of gabapentin and somewhat resembled those of the AMPA/kainate antagonist NBQX and the sodium channel inhibitor phenytoin, but differed from that of benzodiazepine." | 1.39 | Anticonvulsant action of indazole. ( Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Sakamaki, K; Watabe, M, 2013) |
| "Latency for the first seizure, tonic-clonic and generalized seizures time, frequency of seizures and mortality induced by PTZ were recorded." | 1.39 | Anticonvulsant, neuroprotective and behavioral effects of organic and conventional yerba mate (Ilex paraguariensis St. Hil.) on pentylenetetrazol-induced seizures in Wistar rats. ( Branco, Cdos S; Cesio, V; Coitinho, AS; de Freitas, SC; Dos Santos, MT; Fank, B; Heinzen, H; Laprovitera, M; Rodrigues, AD; Salvador, M; Scola, G, 2013) |
| "Thioperamide plays a protective role in seizure development and cognitive impairment of PTZ-induced kindling in rats." | 1.39 | Effects of thioperamide on seizure development and memory impairment induced by pentylenetetrazole-kindling epilepsy in rats. ( Chen, GF; Chen, JF; Ding, MP; Hu, XY; Zhang, LS, 2013) |
| "A clonic-tonic seizure episode was induced by a single i." | 1.39 | A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. ( Aniol, VA; Guekht, AB; Gulyaeva, NV; Ivanova-Dyatlova, AY; Keren, O; Sarne, Y, 2013) |
| "Recurrent generalized seizures were caused by repetitive injection of pentylenetetrazol (PTZ) for a period of 4 weeks every other day." | 1.39 | Behavioural and histopathological assessment of the effects of periodic fasting on pentylenetetrazol-induced seizures in rats. ( Coulon, P; Gharakhani, M; Gorji, A; Jafarian, M; Karimzadeh, F; Kazemi, H; Khallaghi, B; Kolivand, PH; Mohamadzadeh, E; Razeghi Jahromi, S, 2013) |
| "BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific." | 1.39 | Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013) |
| "KM rats exhibited increased seizure severity relative to Wistar rats, and the death of KM rats was observed in 2." | 1.38 | [The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats]. ( Kim, KKh; Lavrent'eva, VV; Lukomskaia, NIa; Magazanik, LG; Vataev, SI; Zaĭtsev, AV; Zhabko, EP, 2012) |
| " The predicted lethal effect and hERG toxicity of the compounds showed that IIa, IVa, Va and Vb might be toxic at higher concentrations." | 1.38 | Synthesis, in silico metabolic and toxicity prediction of some novel imidazolinones derivatives as potent anticonvulsant agents. ( Karthikeyan, C; Moorthy, NS; Saxena, V; Trivedi, P, 2012) |
| "In the present study, 6-Hz seizure threshold, maximal electroshock seizure threshold (MEST) test, and intravenous pentylenetetrazole (i." | 1.38 | Clavulanic acid does not affect convulsions in acute seizure tests in mice. ( Gasior, M; Nieoczym, D; Socała, K; Wlaź, P, 2012) |
| "Finally, we showed that kainate induced seizures and glycemia were not modified by spadin treatments." | 1.38 | Spadin as a new antidepressant: absence of TREK-1-related side effects. ( Borsotto, M; Coppola, T; Gandin, C; Heurteaux, C; Labbal, F; Mazella, J; Moha Ou Maati, H; Veyssiere, J; Widmann, C, 2012) |
| "In animal convulsion models, some anticonvulsants have been found to suppress oxidative reactions associated with convulsions." | 1.38 | Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model. ( Arai, Y; Higuchi, H; Maeda, S; Miyawaki, T; Shimada, M; Tomoyasu, Y, 2012) |
| "Acute epileptic seizure activity was modeled using two mechanistically distinct chemoconvulsants, kainic acid (KA) and pentylenetetrazole (PTZ)." | 1.38 | Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2. ( Claycomb, RJ; Hewett, JA; Hewett, SJ, 2012) |
| "pyrethrum (HEAP) root against seizures, seizure-induced oxidative stress and cognitive impairment in experimental models of seizures." | 1.38 | Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals. ( Gupta, YK; Joshi, S; Mehla, J; Pahuja, M; Reeta, KH, 2012) |
| "Midazolam is a short-acting benzodiazepine that is widely used as an i." | 1.38 | Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012) |
| "After induction of seizure by PTZ, initiation time of myoclonic seizures (ITMS), initiation time of tonic-clonic seizures (ITTS), seizures duration (SD) and mortality rate (MR) were recorded for 30 min." | 1.38 | The antiepileptic effect of sodium valproate during different phases of the estrous cycle in PTZ-induced seizures in rats. ( Azimi, M; Habibian, S; Kaboutari, J; Karimi, B; Shaker, M; Zendehdel, M, 2012) |
| "During drug development, seizure threshold tests are widely used to identify potential proconvulsant activity of investigational drugs." | 1.38 | Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models. ( Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W, 2012) |
| "In two chronic mouse seizure models this clear tasteless oil was found to be reproducibly anticonvulsant." | 1.38 | Triheptanoin in acute mouse seizure models. ( Borges, K; Sweetman, L; Thomas, NK; Willis, S, 2012) |
| "Although NMDAr antagonists decrease seizures, it remains to be determined whether traxoprodil, a selective antagonist at the NR2B subunit of the NMDAr, decreases seizures and whether spermidine facilitates pentylenetetrazol (PTZ)-induced seizures." | 1.38 | Traxoprodil decreases pentylenetetrazol-induced seizures. ( Barron, S; Cocco, AR; Furian, AF; Mello, CF; Naspolini, AP; Oliveira, MS; Rambo, LM; Rubin, MA; Villa Martignoni, F, 2012) |
| "The tonic seizures were prevented by essential oil in both methods at dose of 1mL/kg and higher doses." | 1.38 | Anticonvulsant activity of the essential oil and methanolic extract of Bunium persicum (Boiss). B. Fedtsch. ( Arab-Nozari, M; Mandegary, A; Ramiar, H; Sharififar, F, 2012) |
| "The CD₅₀ values for clonic and tonic seizures after oral administration were 0." | 1.38 | Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. ( Banks, CN; Bruun, DA; Dhir, A; Hammock, BD; Inceoglu, B; Lein, PJ; McCoy, MR; Rogawski, MA; Sanborn, JR; Zolkowska, D, 2012) |
| "Minimal clonic seizures (mS) were moderately potentiated by low doses of CGP7930 in 18-day-old but suppressed by the highest dose in 25-day-old rats." | 1.38 | Anticonvulsant action of GABAB receptor positive modulator CGP7930 in immature rats. ( Mareš, P, 2012) |
| "Ondansetron is a highly selective 5-hydroxytryptamine 3 (5-HT(3)) receptor antagonist used as antiemetic agent for chemotherapy-, and radiotherapy-induced nausea and vomiting." | 1.38 | Evaluation of anticonvulsant and nootropic effect of ondansetron in mice. ( Agarwal, NB; Jain, S; Mediratta, PK; Sharma, KK, 2012) |
| "Atorvastatin has neuroprotective effects, and there is some evidence that nitric oxide is involved in atorvastatin effects." | 1.38 | Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide. ( Dehpour, AR; Fakhrzad, A; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H, 2012) |
| "This reduction of seizure severity was also observed in EEG recording and EEG power analysis." | 1.38 | Anticonvulsant effect of Marsilea quadrifolia Linn. on pentylenetetrazole induced seizure: a behavioral and EEG study in rats. ( Dutta, G; Ghosh, T; Goswami, AR; Mandal, N; Sahu, S, 2012) |
| " A sustained (>20 min) generalized convulsion was induced in Sprague-Dawley juvenile rats by intraperitoneal injection with pentylenetetrazole (PTZ, 70-90 mg/kg) at postnatal day (P) 20." | 1.38 | Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure. ( Mikroulis, AV; Psarropoulou, C, 2012) |
| "Studies have shown that recurrent seizures may increase the concentration of reactive oxygen species, which can lead to oxidative stress and neuronal damage." | 1.38 | Neuroprotective and anticonvulsant effects of organic and conventional purple grape juices on seizures in Wistar rats induced by pentylenetetrazole. ( Coitinho, AS; Dani, C; de Freitas, SC; Fank, B; Henriques, JA; Rodrigues, AD; Salvador, M; Santos, MT; Scheffel, TB; Scola, G; Vanderlinde, R, 2012) |
| " Seizure threshold for PTZ, including the dose-response convulsions and the threshold dose, was compared between NRSF cKO and control mice." | 1.38 | Neuronal conditional knockout of NRSF decreases vulnerability to seizures induced by pentylenetetrazol in mice. ( Cai, L; Fei, J; Liu, M; Sheng, Z; Tian, Y; Zhao, K, 2012) |
| "Seizures were induced 30 min later using a chemoconvulsant (pentylenetetrazol, PTZ) model, which has been widely used to determine anticonvulsant efficacy of many other antiepileptic drugs in neonatal animals." | 1.38 | Anticonvulsant effect of retigabine during postnatal development in rats. ( Forcelli, PA; Gale, K; Kondratyev, A; Lakhkar, A; Soper, C, 2012) |
| "Pretreatment with flumazenil suppressed the anticonvulsant effects of vitexin during the onset of both the seizures." | 1.38 | Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats. ( Abbasi, E; Nassiri-Asl, M; Shafeei, M; Sheikhi, M, 2012) |
| "Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders." | 1.38 | 5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide. ( Amouzegar, A; Bahremand, A; Dehpour, AR; Payandemehr, B; Rahimian, R; Sharifzadeh, M; Ziai, P, 2012) |
| "First, we repeatedly determined the PTZ seizure threshold by i." | 1.38 | Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy. ( Brandt, C; Löscher, W; Rattka, M, 2012) |
| "This beneficial effect of a 4 Hz MF on seizure has the same implication as the anti-oxidative effects of a 4 Hz MF observed in our previous work." | 1.38 | Inhibition of pentylenetetrazole-induced seizure in mice by using a 4 Hz magnetic field: a comparative study with a 60 Hz magnetic field. ( Chae, YJ; Lee, BC; Park, WH; Pyo, MY; Soh, KS, 2012) |
| "The incidence of spontaneous seizures has been reported to be increased in sporadic AD as well as in the early onset autosomal dominant forms of AD." | 1.38 | Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. ( Bales, K; Cirrito, JR; Delong, C; Holtzman, DM; Hunter, JM; Kinley, RD; Koger, D; Lin, S; Liu, F; Paul, SM; Restivo, JL; Sullivan, PM; Zhao, L, 2012) |
| "This seizure-like swimming pattern was alleviated by the addition of either pyridoxal-5'-phosphate (PLP) or GABA and responded quickly to the anti-convulsing activity of gabapentin and phenytoin, two commonly prescribed anti-epileptic drugs (AEDs)." | 1.38 | Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. ( Chang, WN; Du, HC; Fu, TF; Hsiao, TH; Kao, TT; Lee, GH; Safo, MK; Sung, SY, 2012) |
| "Moreover, the seizure susceptibility increased 10 days after diphenhydramine withdrawal in wild-type mice but not in histidine decarboxylase knockout mice, which lack histamine." | 1.38 | Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase. ( Chen, Z; Fan, YY; Fang, Q; He, P; Hu, WW; Ohtsu, H; Xu, TL; Xu, ZH; Yan, HJ; Yang, Y; Zhang, CY; Zhang, XN; Zhong, K, 2012) |
| "Total spike number and the generalized seizure duration were reduced in the carbenoxolone treated group compared to the PTZ group." | 1.38 | Influence of carbenoxolone on the anticonvulsant efficacy of phenytoin in pentylenetetrazole kindled rats. ( Acar, MD; Bagirici, F; Marangoz, C; Sefil, F, 2012) |
| "EDA has been shown to reduce seizures caused by systemic injection of proconvulsants in an animal model of generalized tonic-clonic seizures." | 1.38 | Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety. ( Addae, JI; Cruickshank, R; Stone, TW; Walkins, K, 2012) |
| " This protective effect led to a dose-response curve following a U-shaped form." | 1.38 | Neurohypophyseal hormones protect against pentylenetetrazole-induced seizures in zebrafish: role of oxytocin-like and V1a-like receptor. ( Braida, D; Donzelli, A; Martucci, R; Pauletti, A; Ponzoni, L; Sala, M, 2012) |
| "However, the effect of stress on the convulsion in juvenile animals has been rarely investigated." | 1.38 | Involvement of dopaminergic system in stress-induced anticonvulsant effect in juvenile mice. ( Abe, K; Hiroyama, S; Horiuchi, M; Itoh, T, 2012) |
| "We found that brief seizures immediately resulted in cell cycle retardation in the SVZ." | 1.38 | Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation. ( Hirahara, Y; Koike, T; Kurokawa, K; Mori, T; Takamori, Y; Wakabayashi, T; Yamada, H, 2012) |
| " The results of this study demonstrate a plausible novel anticonvulsant activity of β-carotene at a low dose of 2 mg/kg, with brain-targeted nanodelivery, thus increasing its bioavailability and stability." | 1.38 | Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles. ( Ahmed, B; Khan, M; Khan, RA; Yusuf, M, 2012) |
| "The only seizure test where short-term rapamycin treatment protected mice was against tonic hindlimb extension in the MES threshold test, though this protection waned with longer rapamycin treatment." | 1.38 | The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. ( Dolce, A; Hardwick, JM; Hartman, AL; Santos, P, 2012) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was significantly suppressed by intracerebroventricular (i." | 1.38 | Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal. ( Mori, T; Shibasaki, M; Shimizu, N; Suzuki, T, 2012) |
| "At the spontaneous recurrent seizure period, acute stress stimulations such as cat's urine and foot electrical shock were applied to observe the behavioral changes and seizure occurrence." | 1.38 | [Effect of acute stress stimulation on the seizure induction in epileptic model rats]. ( Ju, JG; Li, ST; Li, XR; Lu, QC; Sun, Z; Wu, SJ; Zhou, P, 2012) |
| "In our previous work the detectors of seizure onset were based on seizure-induced changes in signal power in the frequency range up to 100 Hz, while in this preliminary study we assess the feasibility of recording high frequency oscillations (HFOs) in the range up to 300 Hz noninvasively with scalp TCREs during PTZ-induced seizures." | 1.38 | Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats. ( Besio, WG; Liu, X; Makeyev, O; Medvedev, AV; Taveras, A; Troiano, D; Wang, L; Zhu, Z, 2012) |
| " However, extensive animal studies followed by clinical trials are necessary to develop a product suitable for emergencies of acute seizures in status epilepticus and patients suffering from drug tolerance and hepatic impairment on long-term use in treatment of epilepsy, schizophrenia, and anxiety." | 1.37 | Intranasal clobazam delivery in the treatment of status epilepticus. ( Ambikanandan, M; Ankur, K; Florence, K; Kumar, BA; Kumar, MA; Manisha, L, 2011) |
| "Behavioral and electroencephalographic seizures were monitored for 20 min following pentetrazol administration." | 1.37 | Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure. ( Fukuhara, S; Kaida, Y; Kamei, C; Takechi, K; Uehara, T; Watanabe, Y, 2011) |
| "seizures were induced in 10-day-old Wistar rats with a single convulsive dose (80μg/g b." | 1.37 | A single episode of neonatal seizures alters the cerebellum of immature rats. ( Lomoio, S; Mares, V; Necchi, D; Scherini, E, 2011) |
| "After induction of generalized tonic-clonic seizures by PTZ there were no differences in mRNA at 24h after seizures, equaling baseline quantities except for GAD1, which was decreased." | 1.37 | Differential molecular regulation of glutamate in kindling resistant rats. ( Doi, T; Takaki, M; Ueda, Y; Willmore, LJ, 2011) |
| " To conclude, long term administration of topiramate impairs cognitive functions during experimental epilepsy while lamotrigine and oxcarbazepine are safer." | 1.37 | Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice. ( Agarwal, NB; Agarwal, NK; Mediratta, PK; Sharma, KK, 2011) |
| "KA induced seizure in hippocampus is different to that of both CTA and PTZ." | 1.37 | Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats. ( Chen, L; Kong, S; Qian, B; Sun, Y; Wan, L; Wang, Y; Wang, ZY; Wu, Z; Zhang, B; Zhang, F, 2011) |
| "The analysis of mean latency to seizure onset of nonprotected animals, for specific doses of alkaloids, showed that (+)-erythravine increased latencies to seizures induced by bicuculline." | 1.37 | Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae). ( Beleboni, RO; Cunha, AO; dos Santos, WF; Fachim, HA; Faggion, SA; Gavin, AS; Pereira, AM, 2011) |
| "To assess clonic seizure threshold, pentylenetetrazole (PTZ) was administered intravenously." | 1.37 | Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: role of nitric oxide and μ receptors. ( Baradaran, N; Dehpour, AR; Dehpour, S; Kabiri, T; Moezi, L; Shafaroodi, H, 2011) |
| "Electrical stimulation to control seizures may be an additive therapy." | 1.37 | Transcutaneous focal electrical stimulation via concentric ring electrodes reduces synchrony induced by pentylenetetrazole in beta and gamma bands in rats. ( Besio, WG; Koka, K; Liu, X; Medvedev, AV; Wang, L, 2011) |
| "Memantine has been approved to treat moderate to severe Alzheimer disease (AD), which is characterized by cognitive impairment." | 1.37 | Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats. ( An, LW; Duan, RS; Jia, LJ; Li, ZP; Wang, WP; Zhen, JL, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 1.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| "Female hormones affect seizure severity induced by PTZ, and phytoestrogens of soy mimic this effects." | 1.37 | Effects of soy extract on pentylenetetrazol-induced seizures in ovariectomized rats. ( Alavi, H; Ebrahimzadeh Bideskan, AR; Hosseini, M; Karami, R; Khodamoradi, M; Mohammadpour, T; Nemati Karimooy, H, 2011) |
| "The closed-loop seizure controller was applied to three Long-Evans rats with spontaneous spike-wave discharges (non-convulsive) and three Long-Evans rats with epileptiform activities induced by pentylenetetrazol (PTZ) injection (convulsive) for evaluation." | 1.37 | Closed-loop seizure control on epileptic rat models. ( Chang, DW; Chiueh, H; Liang, SF; Liao, YC; Shaw, FZ; Young, CP, 2011) |
| "Twice-daily dosing of khat did not produce inhibition of weight gain." | 1.37 | Khat (Catha edulis) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model. ( Alele, PE; Rujumba, JB, 2011) |
| "Pentylenetetrazol (PTZ)-induced seizure model was used." | 1.37 | [Sedative, hypnotic and anticonvulsive effects of an adenosine analogue WS090501]. ( Li, W; Zhang, JJ, 2011) |
| "Recurrent seizure activity has been shown to induce a variety of permanent structural changes in the brain." | 1.37 | Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. ( Ibi, D; Itohara, S; Kamei, H; Koike, H; Mizoguchi, H; Nabeshima, T; Nakade, J; Sato, J; Sawada, M; Someya, E; Tachibana, M; Takuma, K; Yamada, K, 2011) |
| "Bucladesine significantly decreased seizure latency and threshold only at a high concentration (300 nM/mouse)." | 1.37 | Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice. ( Azami, K; Beyer, C; Ghadiri, T; Gholizadeh, S; Hosseini-Zare, MS; Mobasseri, M; Salehi, F; Seyedi, SY; Sharifzadeh, M, 2011) |
| "Latency to the first minimal clonic seizure (MCS) and generalized tonic-clonic seizure (GTCS) and the percent of mortality of rats in each group were recorded." | 1.37 | Effects of different extracts of Rosa damascena on pentylenetetrazol-induced seizures in mice. ( Ghasemzadeh Rahbardar, M; Hosseini, M; Rakhshandeh, H; Sadeghnia, HR, 2011) |
| "Knockdown of lgi1a results in a seizure-like hyperactivity phenotype with associated developmental abnormalities characterized by cellular loss in the eyes and brain." | 1.37 | Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior. ( Cowell, JK; Kozlowski, DJ; Mumm, JS; Saxena, M; Teng, Y; Walker, S; Xie, X, 2011) |
| " Thus we aim to evaluate the effect of an increase in Cstb gene dosage on spontaneous epileptic activity and susceptibility to PTZ-induced seizure." | 1.37 | Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. ( Bizot, JC; Brault, V; Costet, N; Hérault, Y; Martin, B, 2011) |
| "Epilepsy is suppressed by reducing the temperature to reduce the duration of this epileptic episode." | 1.37 | Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling. ( Chang, CW; Chiou, JC; Hou, KC; Huang, YH; Shaw, FZ, 2011) |
| "Here we report on the development of a seizure detecting algorithm to be used for automatic application of TFS." | 1.37 | Algorithm for automatic detection of pentylenetetrazole-induced seizures in rats. ( Besio, WG; Koka, K; Liu, X; Liu, Y; Medvedev, AV; Sun, YL, 2011) |
| " VCU was mainly eliminated by metabolism with a half-life of 2 h." | 1.36 | Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative. ( Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B, 2010) |
| "All samples reduced SMA and inhibited catalepsy." | 1.36 | Ayurvedic processed seeds of nux-vomica: neuropharmacological and chemical evaluation. ( Bhattacharya, SK; Katiyar, C; Kumar, A; Singh, RS, 2010) |
| "Overall, the results indicate that seizure may be associated with an increase in energy demand, altered neurotransmitter balance and an increase in neuronal loss and gliosis." | 1.36 | Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain. ( Brennan, L; Carmody, S, 2010) |
| "Zolpidem is a widely used hypnotic drug acting via benzodiazepine binding sites on GABA(A) receptors." | 1.36 | Zolpidem is a potent anticonvulsant in adult and aged mice. ( Pericić, D; Vlainić, J, 2010) |
| "There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e." | 1.36 | Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide. ( Dehpour, AR; Ghaffarpour, M; Ghasemi, M; Gholipour, T; Riazi, K, 2010) |
| "Lamotrigine treatment had no effect on oxidative stress parameters alone, while it significantly decreased oxidative stress in the pentylenetetrazole-kindled group as compared to the pentylenetetrazole-kindled carbamazepine-treated group." | 1.36 | Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in rats. ( Arora, T; Banerjee, BD; Garg, GR; Mediratta, PK; Mehta, AK; Sharma, AK; Sharma, KK, 2010) |
| "Palmitone is a secondary metabolite of polyketide origin extracted from leaves of Annona diversifolia Saff." | 1.36 | Palmitone prevents pentylenetetrazole-caused neuronal damage in the CA3 hippocampal region of prepubertal rats. ( Blas-Valdivia, V; Cano-Europa, E; González-Trujano, ME; Hernández-García, A; Ortiz-Butrón, R; Reyes-Ramírez, A, 2010) |
| "The latency to onset of clonic seizure and the PTZ threshold were recorded." | 1.36 | [Drugs and the mechanism for reversing the tolerance of flurazepan in rats]. ( Bian, FZ; Wang, L; Wang, YH; Wang, YX, 2010) |
| "Levetiracetam (LEV) is a unique antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 1.36 | Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model. ( Ishihara, S; Ohno, Y; Sasa, M; Serikawa, T; Terada, R, 2010) |
| "asiatica; and PTZ-induced seizure rats pretreated with diazepam (2mg/kg body wt)." | 1.36 | Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. ( Chetan, PS; Lokanatha, V; Prasad, KS; Rajendra, W; Visweswari, G, 2010) |
| "The first group ("seizure-tested rats") received saline, OA, or DHA (400mg/kg) subcutaneously, and were seizure tested in the maximal PTZ test 1 hour later to confirm the seizure latency measurements at that time." | 1.36 | Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats. ( Bala, S; Burnham, WM; Jeffrey, MA; Taha, AY; Taha, NM, 2010) |
| "After PTZ administration, mice showed myoclonic seizure (MCL) and clonic seizure (CL) in order." | 1.36 | Effects of antiepileptics on behavioral and electroencephalographic seizure induced by pentetrazol in mice. ( Fujiwara, A; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| "Based on their seizure scores during treatment and in a screening test performed 2 weeks post-treatment, the PTZ-treated animals were retrospectively divided into the kindled group and the unkindled group." | 1.36 | Increased hippocampal T2 in a rat model of pentylenetetrazol-induced kindling correlates with seizure scores. ( Fang, F; Lei, H, 2010) |
| "PTZ provoked clonic convulsions, reduced GABA content, deranged brain redox status, and elevated nitric oxide (NO)." | 1.36 | Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats. ( Abdallah, DM; Abdel-Aziz, MT; Arafa, NM; Safar, MM, 2010) |
| "Seizures are a common phenotype in all of these neurological disorders, yet the underlying molecular mechanism(s) of seizure induction and propagation remain largely unknown." | 1.36 | Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures. ( Malter, JS; Westmark, CJ; Westmark, PR, 2010) |
| "Kindling of seizures induced time-, seizure-, and structure-dependent increases in the local levels of NA, 5-HT, 5-hydroxyindolacetic acid, DA, homovanillic acid, and 3,4-dihydroxyphenylacetic acid." | 1.36 | Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats. ( Bidziński, A; Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D, 2010) |
| "Rutin is a flavonoid that is an important dietary constituent of foods and plant-based beverages." | 1.36 | The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats. ( Abbasi, E; Mortazavi, SR; Nassiri-Asl, M; Safdari, F; Samiee-Rad, F; Saroukhani, S; Zangivand, AA, 2010) |
| "Inverse correlations between seizure severity and the numbers of neurons in hippocampal fields CA1 and CA3 and the dentate fascia were seen in rats subjected to kindling." | 1.36 | Acquisition of an active avoidance reaction in rats and morphological changes in the hippocampus in pentylenetetrazol kindling. ( Gekht, AB; Gulyaeva, NV; Pavlova, TV; Stepanichev, MY, 2010) |
| "PTZ) or kainic acid (i." | 1.36 | Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose. ( French, A; Gasior, M; Hartman, AL; Rogawski, MA; Yankura, J, 2010) |
| "The latency for development of convulsions and mortality rate was recorded in these models using mice." | 1.36 | Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. ( Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S, 2010) |
| "For the anticonvulsant testing, seizure was induced by injection of pentylenetetrazole (PTZ), 90 mg/kg intraperitoneally (i." | 1.36 | Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species. ( Bagheri, SM; Gohari, AR; Iranshahi, M; Malmir, M; Saeidnia, S; Sahebkar, A, 2010) |
| "PTZ injection induced clonic seizures in MCH(1)R-WT mice but failed to induce them in MCH(1)R-KO mice." | 1.36 | Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures. ( Civelli, O; Gohil, K; Okumura, SM; Parks, GS, 2010) |
| "Minimal clonic seizures in 18-day and older rats were suppressed by high doses of 2-chloroadenosine." | 1.36 | Anticonvulsant action of 2-chloroadenosine against pentetrazol-induced seizures in immature rats is due to activation of A1 adenosine receptors. ( Mareš, P, 2010) |
| "Seizure and seizure-like behaviors were scored by examination of video collected for 20min." | 1.36 | Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors. ( Cursons, RT; Jacobson, GM; Mason, JP; Melin, SM; Sleigh, JW; Steyn-Ross, DA; Steyn-Ross, ML; Voss, LJ, 2010) |
| "shortening seizure latency and inducing a more profound increase of NO production than PTZ in all brain structures." | 1.36 | Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures. ( Bjelaković, G; Jelenković, A; Jevtović-Stoimenov, T; Pavlović, D; Stevanović, I; Stojanović, I, 2010) |
| "We report that brief seizures evoked by electroshock produced an increase in the number of NPY neurons in the dentate hilus and retrosplenial cortex, an effect that lasted 10 weeks." | 1.36 | Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis. ( Cardoso, A; Carvalho, LS; Freitas-da-Costa, P; Lukoyanov, NV, 2010) |
| "Our data revealed that seizure threshold was increased 6 to 72 hours after nasal obstruction, reaching a peak 48 hours afterward, compared with either control or sham-operated mice (P<0." | 1.35 | Mouth breathing increases the pentylenetetrazole-induced seizure threshold in mice: a role for ATP-sensitive potassium channels. ( Dehpour, AR; Fakhimi, A; Ghasemi, M; Niaki, SE; Shafaroodi, H; Shakiba, B, 2008) |
| "Most seizures stop spontaneously; however, the molecular mechanisms that terminate seizures remain unknown." | 1.35 | Seizure termination by acidosis depends on ASIC1a. ( Albert, GW; Howard, MA; Schnizler, MK; Severson, MA; Welsh, MJ; Wemmie, JA; Ziemann, AE, 2008) |
| "The evidence derived from animal seizure models, however, has been contradictory." | 1.35 | Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. ( Filo, E; Ma, DW; McIntyre Burnham, W; Taha, AY, 2009) |
| "In NPN2 deficient mice, we measured seizure susceptibility after kainic acid or pentylenetetrazol, neuronal excitability and synaptic throughput in slice preparations, principal and interneuron cell counts with immunocytochemical protocols, synaptosomal protein levels with immunoblots, and dendritic morphology with Golgi-staining." | 1.35 | Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy. ( Bachstetter, A; Barnes, GN; Blalock, EM; Gant, JC; Hauser, KF; Kotick, J; Li, Y; Mervis, R; Schauwecker, PE; Smith, GM; Thibault, O; Yang, J, 2009) |
| "Latency for seizures in control animals was 3,120+/-770 s (S." | 1.35 | Anticonvulsant serotonergic and deep brain stimulation in anterior thalamus. ( Chiang, J; Hinich, M; Mirski, MA; Sherman, D; Ziai, WC, 2009) |
| "Nicotine pretreatment reversed the anti-lipid peroxidative action of sodium valproate in the PTZ-induced seizure model in mice." | 1.35 | Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice. ( Chakrabarti, A; Medhi, B; Sahai, AK; Sood, N, 2008) |
| "Seizures were assessed in terms of the time latency of the onset of Straub's tail phenomenon, onset of jerky movements of whole body, convulsions and death." | 1.35 | Tramadol-induced seizurogenic effect: a possible role of opioid-dependent gamma-aminobutyric acid inhibitory pathway. ( Kumar, M; Rehni, AK; Singh, I, 2008) |
| "Cholestasis decreased seizure activity and increased lag phase before seizure and both effects were decreased by dithizone injection." | 1.35 | Effect of metal chelating agents on pentylenetetrazole-induced seizure threshold in cholestatic mice. ( Dehpour, AR; Ghasemi, M; Kebriaeezadeh, A; Mehr, SE; Nouri, M; Rayatzadeh, H, 2009) |
| "Ethanol-induced retrograde amnesia was investigated using a new odor-recognition test." | 1.35 | Alcohol-induced retrograde memory impairment in rats: prevention by caffeine. ( Cormack, LK; Feinberg, LM; Schallert, K; Schallert, T; Spinetta, MJ; Stroud, C; Woodlee, MT, 2008) |
| "Memantine suppressed generalized tonic-clonic seizures in all age groups; minimal seizures were potentiated." | 1.35 | Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats. ( Mares, P; Mikulecká, A, 2009) |
| "Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels." | 1.35 | Antiepileptic effects of quinine in the pentylenetetrazole model of seizure. ( Nassiri-Asl, M; Torabinejad, B; Zamansoltani, F, 2009) |
| " However, in both groups chronic administration of melatonin (20mg/kg) reversed the effect of LD cycle alteration on CST." | 1.35 | Effect of acute and chronic photoperiod modulation on pentylenetetrazole-induced clonic seizure threshold in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2008) |
| "Pentylenetetrazole (10mg/ml/min) was continuously infused through an intravenous catheter to induce seizures while four different patterns of temporally coded electrical stimulation were applied: periodic stimulation (PS), pseudo-randomized IPI stimulation (LH), restrictively randomized IPI stimulation (IH), and bursts of 20-ms IPIs (burst)." | 1.35 | Distinct patterns of electrical stimulation of the basolateral amygdala influence pentylenetetrazole seizure outcome. ( Cota, VR; Doretto, MC; Medeiros, Dde C; Moraes, MF; Vilela, MR, 2009) |
| "Khat lowers seizure threshold." | 1.35 | Proconvulsant effect of khat (Catha edulis) in Sprague dawley rats. ( Kioy, PG; Oyungu, E; Patel, NB, 2009) |
| "nNOS(-/-) mice exhibited severe convulsions following injection with a subconvulsive dose of PTZ (40 mg/kg i." | 1.35 | Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase. ( Itoh, K; Watanabe, M, 2009) |
| "Using model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice, we investigated whether NO is involved in the effects of cannabinoids on the seizure threshold." | 1.35 | Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Nasrabady, SE; Shafaroodi, H, 2009) |
| "The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described." | 1.35 | Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. ( Cook, JM; Edwankar, CR; Edwankar, RV; Furtmüller, R; Huang, S; Jain, HD; Majumder, S; Murphree, L; Ramerstorfer, J; Rivas, FM; Roth, BL; Sankar, S; Sieghart, W; Stables, JP; Zhou, H, 2009) |
| "The average duration of a single EEG seizure did not differ in these groups." | 1.35 | [Seizure activity in the EEG of rats sensitive and resistant to pentylenetetrazol kindling]. ( Fesenko, GN; Gekht, AB; Gulieva, NV; Koval'zon, VM; Pavlova, TV, 2009) |
| "After repeated treatment the PTZ seizure threshold was not different between the two drugs, while differences in sedation became larger than after the acute treatment." | 1.35 | Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam. ( Pericić, D; Vlainić, J, 2009) |
| "To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used." | 1.35 | Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. ( Krzyzanowski, M; Luszczki, JJ; Swiader, MJ, 2009) |
| "maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ), subcutaneous strychnine (scSTY), and subcutaneous picrotoxin (scPIC)-induced seizure threshold tests." | 1.35 | Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one. ( Shalini, M; Sriram, D; Stables, JP; Yogeeswari, P, 2009) |
| "It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood." | 1.35 | Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures. ( Gonzalez-Ramirez, M; Orozco-Suarez, SA; Rocha, L; Salgado-Ceballos, H, 2009) |
| "The intensities of seizures induced by pentylenetetrazol or pilocarpine, as well as the percentages of convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R KO) animals." | 1.35 | Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2009) |
| "This type of seizures never appeared in caffeine-treated 25-day-old animals." | 1.35 | Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats. ( Kubová, H; Mares, P; Tchekalarova, J, 2009) |
| "Severity of kindled seizures was assessed in terms of a composite kindled seizure severity score (KSSS)." | 1.35 | Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice. ( Kalra, R; Rehni, AK; Singh, N; Singh, TG, 2009) |
| "Flumazenil pretreatment decreased the prolongation of seizure latency induced by both diazepam and isopulegol, although it was not able to reverse the latency and protection percent for mortality." | 1.35 | Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity. ( de Aquino Neto, MR; de Lavor, EP; de Sousa, DP; de Sousa, FC; de Sousa, HL; de Vasconcelos, PF; Macêdo, DS; Moura, BA; Silva, MA; Silva, MI; Vasconcelos, SM, 2009) |
| "However, the effects of brief seizures on learning and memory remain unknown." | 1.35 | Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory. ( Cao, J; Mao, RR; Tian, M; Xu, L; Yang, YX; Zhou, QX, 2009) |
| "To test this we compared seizure kindling rates using the pentylenetetrazol (PTZ) model of epileptogenesis in sensitized and unsensitized adult Sprague-Dawley rats." | 1.35 | Acceleration of pentylenetetrazol seizure kindling associated with induction of sensitized visual responses evoked by strobe stimulation. ( Manning, KA; Uhlrich, DJ, 2009) |
| "The PTZ-induced seizures gradually increased in intensity." | 1.35 | A revised Racine's scale for PTZ-induced seizures in rats. ( Fabene, PF; Lüttjohann, A; van Luijtelaar, G, 2009) |
| " The present study carried out to evaluate the effect of chronic administration of L-arginine (LA) and L-NAME (LN) on pentylenetetrazole (PTZ) induced epilepsy in ovariectomized (OVX) and naïve female rats." | 1.35 | The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo study. ( Alavi, H; Gorji, A; Hosseini, M; Sadeghnia, HR; Salehabadi, S, 2009) |
| "Actions at ERbeta may underlie some antiseizure effects of T's metabolites." | 1.35 | Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta. ( Frye, CA; Rhodes, M; Ryan, A, 2009) |
| "Tonic flexion convulsion was occurred three fifth in the wild type mice group by administration of PTZ, but tonic flexion was not observed in NCX1 knockout mice groups." | 1.35 | Involvement of Na+/Ca2+ exchanger in pentylenetetrazol-induced convulsion by use of Na+/Ca2+ exchanger knockout mice. ( Baba, A; Honda, K; Iwamoto, T; Kaneko, E; Kita, S; Komuro, I; Matsuda, T; Saito, R; Takano, Y; Tanaka, Y, 2009) |
| "Accordingly, the risk of occurrence of convulsion related to TBPM-PI administration was low compared to IPM/CS administration, and TBPM-PI was considered to be less potential to induce convulsions in clinical use." | 1.35 | [Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil]. ( Kurata, Y; Kurosawa, T; Nawa, T; Shibasaki, S; Suzuki, H; Yagi, Y, 2009) |
| "Epilepsy is a common (50 million patients worldwide) neurological disorder characterized by seizures that are caused by episodic abnormal electrical activity in the brain." | 1.35 | Acute seizure tests in epilepsy research: electroshock- and chemical-induced convulsions in the mouse. ( Gasior, M; Giardina, WJ, 2009) |
| "It suppressed tonic phase of generalized seizures induced by pentetrazol in 7-, 12- and 18-day-old rats and increased their latency in 7- and 12-day-old animals." | 1.35 | Anticonvulsant action of GABA-B receptor agonist SKF97541 differs from that of baclofen. ( Mares, P, 2008) |
| " The results showed proconvulsant effect of gatifloxacin (50 mg/kg) in pentylenetetrazole-induced seizure test after both short- and long-term administration studies." | 1.35 | Anxiogenic and proconvulsant effect of gatifloxacin in mice. ( Bharal, N; Gupta, S; Khurana, S; Mediratta, PK; Sharma, KK, 2008) |
| "They show, in two rodent seizure models, that leptin administered directly to the brain or nasal epithelium suppresses seizures via direct effects on glutamate neurotransmission in the hippocampus." | 1.35 | Anticonvulsant effects of leptin in epilepsy. ( Diano, S; Horvath, TL, 2008) |
| "The role of PGE(2) in the convulsions induced by PTZ was further investigated by administering anti-PGE(2) antibodies (4 microg/2 microl, i." | 1.35 | Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures. ( Bohrer, D; Castelli, M; Cavalheiro, EA; Ferreira, J; Fighera, MR; Fiorenza, NG; Furian, AF; Machado, P; Mello, CF; Oliveira, MS; Royes, LF; Veiga, M, 2008) |
| "This study was designed to characterize seizures induced with pentylenetetrazol (PTZ) in marmosets." | 1.35 | Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset. ( Bachiega, JC; Blanco, MM; Cinini, SM; Covolan, L; Mello, LE; Perez-Mendes, P, 2008) |
| "Pretreatment with rofecoxib (1." | 1.35 | Rofecoxib potentiates the anticonvulsant effect of topiramate. ( Akula, KK; Dhir, A; Kulkarni, SK, 2008) |
| "When seizures were induced by systemic injection of kainate, only SST(4) knock-outs showed an increase in seizure sensitivity." | 1.35 | Somatostatin receptor subtype 4 couples to the M-current to regulate seizures. ( de Lecea, L; Hochgeschwender, U; Johnson, B; Qiu, C; Tallent, MK; Zeyda, T, 2008) |
| "The present study showed that epileptic seizures induced by convulsive PTZ challenge during kindling-mediated epileptogenesis in the presence of CD changed both functional and ultrastructural properties of the BBB and considerably enhanced transendothelial vesicular transport, while paracellular pathway was apparently not involved in this setting." | 1.35 | Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia. ( Ahishali, B; Arican, N; Bilgic, B; Ekizoglu, O; Elmas, I; Gurses, C; Kalayci, R; Kaya, M; Kemikler, G; Kucuk, M; Oku, B; Orhan, N; Ustek, D, 2008) |
| "If treated with propofol alone (2 and 5 mg/kg), there was no significant difference as compared to controls." | 1.35 | Effect of propofol in altering pentylenetetrazol induced seizure threshold in rats. ( Medhi, B; Prakash, A; Puri, A; Saikia, B, 2008) |
| "Thus, for these mice, the antiseizure effects of 3*-diol for the chemoconvulsant PTZ occur independent of actions at ERbeta." | 1.35 | Antiseizure effects of 5*-androstane-3*,7beta-diol may be independent of actions at estrogen receptor beta. ( Frye, CA; Ryan, A, 2008) |
| "Furthermore, the increase in seizure threshold elicited by adenosine (100 mg/kg i." | 1.35 | Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol-induced seizure threshold in mice. ( Akula, KK; Dhir, A; Kulkarni, SK, 2008) |
| "Occurrence of seizures following long-term oral administration of caffeine (0." | 1.35 | Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. ( Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM, 2008) |
| "Thus, concerning the seizure modulating properties of both classes of receptors this study investigated whether the ultra-low dose opioid antagonist naltrexone influences cannabinoid anticonvulsant effects." | 1.35 | The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Gholizadeh, S; Nasrabady, SE; Shafaroodi, H, 2008) |
| "Decreased thresholds for PTZ-induced seizures were also observed in KOPr-1 knock out mice." | 1.34 | Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling. ( Kaminski, RM; Shippenberg, TS; Witkin, JM, 2007) |
| "Because seizures represent a strong distressing stimulus, stress-induced proteins such as heat shock proteins might counteract the pathology of increased neuronal excitation." | 1.34 | Pentylenetetrazol-kindling in mice overexpressing heat shock protein 70. ( Ammon-Treiber, S; Angelidis, C; Becker, A; Grecksch, G; Höllt, V; Vezyraki, P, 2007) |
| "On day 64 the escape latency of the seizure group was 82,424 ms +/- 35,622 ms, significantly longer than that of the control group (40,712 ms +/- 29,468 ms, P = 0." | 1.34 | [Long-term effects of recurrent seizures in neonate period on gamma-aminobutyric acid A receptor alpha1 and beta2 subunits expression in adult brain: experiment with rats]. ( Bo, T; Chen, Y; Li, YF; Mao, DA; Zhu, XH, 2007) |
| "Many potential treatments for Alzheimer's disease target amyloid-beta peptides (Abeta), which are widely presumed to cause the disease." | 1.34 | Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. ( Cheng, IH; Gerstein, H; Mucke, L; Palop, JJ; Roberson, ED; Scearce-Levie, K; Wu, T; Yan, F; Yu, GQ, 2007) |
| "Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown." | 1.34 | Modified variant of the Rieske iron-sulfur protein in the hippocampus of kindled rats and human epileptic patients. ( Dunoiu, C; Ioana, M; Mogoantă, L; Petcu, EB; Pirici, D; Popa-Wagner, A, 2007) |
| "In order to generate epileptic seizures, PTZ (50mg/kg) was injected intraperitoneally." | 1.34 | Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. ( Bilgin, HM; Obay, BD; Sermet, A; Tasdemir, E; Tümer, C, 2007) |
| "Seizures were induced by PTZ injection intraperitoneally (i." | 1.34 | Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field. ( Canseven, AG; Keskil, S; Keskil, ZA; Seyhan, N, 2007) |
| " In addition, modafinil at 180 mg/kg exerted an antiepileptic effect in the MES model; however, at the same dosage it increased the seizure stage in the PTZ-kindling model." | 1.34 | Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice. ( Chen, CR; Huang, ZL; Qiu, MH; Qu, WM; Urade, Y; Xu, XH; Yao, MH, 2007) |
| "Evans-blue was used as a BBB tracer." | 1.34 | Gender difference in the influence of antioxidants on the blood-brain barrier permeability during pentylenetetrazol-induced seizures in hyperthermic rat pups. ( Akgul, S; Oztas, B; Seker, FB, 2007) |
| "In the PTZ-induced seizures, KA at doses of 0." | 1.34 | On the anticonvulsant activity of kaurenic acid. ( Daló, NL; Sosa-Sequera, MC; Usubillaga, A, 2007) |
| "However, regarding the seizure modulating properties of both classes of receptors this study investigated whether ultra-low dose cannabinoid antagonist AM251 influences cannabinoid anticonvulsant effects." | 1.34 | Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. ( Bahremand, A; Dehpour, AR; Ghasemi, M; Gholizadeh, S; Shafaroodi, H; Sharifzadeh, M, 2007) |
| "cefazolin was also reversed by different doses of diazepam (0." | 1.34 | Pro-convulsant effect of cefazolin sodium against pentylenetetrazol- or picrotoxin-induced convulsions in mice. ( Akula, KK; Dhir, A; Kulkarni, SK, 2007) |
| "The effects of chronic administration of pentylenetetrazole (PTZ) during early ontogenesis (from postnatal day 14) on the dynamics of age-related changes in electrophysiological characteristics of rat hippocampal slices were studied." | 1.34 | Kindling in the early postnatal period: Effects on the dynamics of age-related changes in electrophysiological characteristics of hippocampal neurons. ( Egorova, LK; Gulyaeva, NV; Kudryashov, IE; Kudryashova, IV; Pavlova, TV, 2007) |
| "Convulsions were followed by statistically significant increase in the tail-flick latencies (TFL), at least for 120 min of the postictal period." | 1.33 | Intrinsic neural circuits between dorsal midbrain neurons that control fear-induced responses and seizure activity and nuclei of the pain inhibitory system elaborating postictal antinociceptive processes: a functional neuroanatomical and neuropharmacologi ( Carvalho, AD; Coimbra, NC; Elias-Filho, DH; Ferreira, CM; Freitas, RL; Garcia-Cairasco, N; Ribeiro, SJ, 2005) |
| "Progesterone has antiseizure effects, which may be due to the actions of its 5alpha-reduced metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP)." | 1.33 | Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures. ( Frye, CA; Rhodes, ME, 2005) |
| "infusion of PTZ; (2) suppress the seizures (clonic and tonic) and lethality induced by i." | 1.33 | Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice. ( Narenjkar, J; Sayyah, M; Yousefi-Pour, M, 2005) |
| "Rodent seizure models have significantly contributed to our basic understanding of epilepsy." | 1.33 | Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. ( Baier, H; Baraban, SC; Castro, PA; Taylor, MR, 2005) |
| "The LH diet induced an increase in seizure response (seizure susceptibility) to the first trial of PTZ, and resulted in facilitation of subsequent PTZ kindling process (seizure development)." | 1.33 | Influence of low dietary histamine on seizure development of chemical kindling induced by pentylenetetrazol in rats. ( Chen, Z; Jin, CL; Kiso, Y; Luo, JH; Sakurai, E; Yanai, K, 2005) |
| "In PTZ-induced epileptic seizures, the i." | 1.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "Both extracts can prevent convulsions as well as convulsion-related GABAergic neuron damage in the brain in the prolonged PTZ kindling model." | 1.33 | Study of antiepileptic effect of extracts from Acorus tatarinowii Schott. ( Chen, L; Gao, MM; Liao, WP; Su, T; Sun, WW; Yang, SQ; Yi, YH, 2005) |
| "In the pentylenetetrazole-seizure, it increased the first convulsion latency, diminished the severity of convulsions, reduced the percentage of animals which developed convulsion (50% and 25%) and protected animals from death." | 1.33 | Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense. ( Blanco, MM; Cunha, GM; Do Monte, FH; Dos Santos, JG; Lanziotti, VM; Leal, LK; Russi, M, 2005) |
| "However, this antagonist did not inhibit clonic seizures produced by pentylenetetrazol." | 1.33 | Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. ( Kingston, AE; Peters, SC; Shannon, HE, 2005) |
| "The latency and incidence of seizures were recorded by an observer who was uninformed of the estrous cycle and dietary treatment conditions of the rats." | 1.33 | Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. ( Frye, CA; Harney, JP; Rhodes, ME; Talluri, J, 2005) |
| "All subjects were seizure tested by using the PTZ infusion test." | 1.33 | A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats. ( Abdelmalik, PA; Burnham, WM; Clarke, J; Likhodii, S; Nylen, K, 2005) |
| "Agmatine pre-treatment significantly reduced the seizure grade and increased the onset time." | 1.33 | Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. ( Feng, Y; LeBlanc, MH; Regunathan, S, 2005) |
| "Maximal electroshock seizures (MES) in albino rats and pentylenetetarazole (PTZ) induced seizures in albino mice were used to study anticonvulsant activity of Vitex-negundo leaf extract." | 1.33 | An experimental evaluation of anticonvulsant activity of Vitex-negundo. ( Gupta, RK; Tandon, VR, 2005) |
| " Both acute and chronic administration of quercetin (25 or 50 mg/kg, p." | 1.33 | Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions. ( Joshi, D; Kulkarni, SK; Naidu, PS; Singh, A, 2005) |
| "Seizures were found to be more severe in females." | 1.33 | Nitric oxide involvement in seizures elicited by pentylentetrazol and sex dependence. ( Akgün-Dar, K; Bahçekapili, N; Diler, AS; Uzüm, G; Ziylan, YZ, 2005) |
| "Pentylenetetrazole (PTZ) is a chemical kindling agent used to examine the efficacy of potential anticonvulsants in rats." | 1.33 | Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats. ( Dunbar, GL; Ericson, M; Hulce, VD; Mortazavi, F; Story, D, 2005) |
| "Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy." | 1.33 | Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene. ( Kalueff, AV; Keisala, T; Kuuslahti, M; Miettinen, S; Minasyan, A; Tuohimaa, P, 2006) |
| "Seizures were observed and evaluated regard to latency and intensity for an hour." | 1.33 | Erythropoietin prevents the increase in blood-brain barrier permeability during pentylentetrazol induced seizures. ( Bahçekapili, N; Sarper Diler, A; Uzüm, G; Ziya Ziylan, Y, 2006) |
| "However, the seizure threshold of AE3-knockout mice exposed to bicuculline, pentylenetetrazole, or pilocarpine was reduced, and seizure-induced mortality was significantly increased compared to wild-type littermates." | 1.33 | Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold. ( Gal, A; Hentschke, M; Hentschke, S; Hermans-Borgmeyer, I; Hübner, CA; Jentsch, TJ; Kurth, I; Seidenbecher, T; Wiemann, M, 2006) |
| "(1) In the three groups, the latency of seizure and the latency of IV/V grade were significantly lower in the rats of group P10 and P20 [(1." | 1.33 | [Pathological changes of brain at different maturational stages caused by pentylenetetrazol-induced repeated seizure in rat models]. ( Huang, YL; Liu, YL; Sun, D, 2005) |
| " To assess pharmacodynamic and neurochemical effects of zolpidem, open-field behavior, pentylenetetrazole-induced seizure threshold and benzodiazepine receptor binding in vitro were evaluated in the same animal following a single dose of zolpidem." | 1.33 | Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses. ( Fahey, JM; Grassi, JM; Greenblatt, DJ; Reddi, JM, 2006) |
| "Recurrent seizures were induced by injecting rat pups with pentylenetetrazole (PTZ) between P10 (10 days of age) and P14." | 1.33 | Menhaden fish oil improves spatial memory in rat pups following recurrent pentylenetetrazole-induced seizures. ( Chaung, HC; Chen, CC; Chung, MY; Huang, LT, 2006) |
| "In the seizure development process, 500 mg/kg carnosine also significantly delayed the onset of PTZ kindled seizures." | 1.33 | Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat. ( Chen, Z; Ding, MP; Jin, CL; Wu, XH; Zhu, YY; Zhu-Ge, ZB, 2006) |
| "delta-Opioid agonists produce convulsions and antidepressant-like effects in rats." | 1.33 | The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol. ( Baladi, MG; Folk, JE; Jutkiewicz, EM; Rice, KC; Woods, JH, 2006) |
| "Doripenem and meropenem did not induce convulsions at up to 100 microg/mouse." | 1.33 | Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics. ( Abe, K; Arai, T; Hasebe, N; Horiuchi, M; Kimura, M; Tokumura, M, 2006) |
| "Kainate-induced seizures decrease zinc concentrations in the hippocampus, which is also decreased in young mice fed a zinc-deficient diet for 4 weeks, and is enhanced by zinc deficiency." | 1.33 | Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency. ( Hirate, M; Itoh, H; Oku, N; Takeda, A, 2006) |
| "Ethosuximide (ESM) also was used to block seizure activity." | 1.33 | Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures. ( Brevard, ME; Ferris, CF; King, JA; Kulkarni, P, 2006) |
| "In addition, convulsive seizure activity was induced by systemic administration of either 4-aminopyridine (4-AP; 10 mg/kg, i." | 1.33 | Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel. ( Henry, M; Hescheler, J; Kamp, M; Krieger, A; Radhakrishnan, K; Schneider, T; Weiergräber, M, 2006) |
| "Thus, rats " tolerant" to developing convulsions show signs of oxidative stress and neurodegenerative changes in the hippocampus." | 1.33 | Pentylenetetrazol kindling in rats: Is neurodegeneration associated with manifestations of convulsive activity? ( Gulyaeva, NV; Pavlova, TV; Stepanichev, MY; Yakovlev, AA, 2006) |
| "Convulsions were followed by statistically significant increase in the tail-flick latencies (TFL), at least for 120 min of the post-ictal period." | 1.33 | Involvement of 5-HT(2) serotonergic receptors of the nucleus raphe magnus and nucleus reticularis gigantocellularis/paragigantocellularis complex neural networks in the antinociceptive phenomenon that follows the post-ictal immobility syndrome. ( Coimbra, NC; de Oliveira, R; de Oliveira, RC; Ferreira, CM, 2006) |
| "Onset, duration of clonic convulsions and percentage mortality/recovery were recorded." | 1.33 | Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2006) |
| "In contrast, the incidence of seizures was reduced 18 h after LPS injection." | 1.33 | The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction. ( Akarsu, ES; Algan, E; Ozdayi, S; Ulupinar, F, 2006) |
| "Prazosin potentiated the anti-seizure effect of Ang III against MTW, GNCL, and THE in non-stressed mice while it reversed the seizure threshold-decreasing effect of this heptapeptide on MTW and GNCL in stressed mice." | 1.33 | Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism. ( Georgiev, V; Tchekalarova, J, 2006) |
| "Generalized seizures caused by the GABA(A) receptor antagonist, metrazole, induced the IEG, ZENK, in zebra finch brain." | 1.33 | Singing, but not seizure, induces synaptotagmin IV in zebra finch song circuit nuclei. ( Byun, JS; Herschman, HR; Poopatanapong, A; Teramitsu, I; Vician, LJ; White, SA, 2006) |
| "At subthreshold doses for seizure induction, picrotoxin produced an increased frequency of motor neuron action potential bursting, indicating that CNS GABAergic transmission regulates patterned activity." | 1.33 | Development of a Drosophila seizure model for in vivo high-throughput drug screening. ( Chouinard, SW; Littleton, JT; Saraswati, S; Stilwell, GE, 2006) |
| "Pretreatment with rofecoxib (1-5." | 1.33 | Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice. ( Dhir, A; Kulkarni, SK, 2006) |
| "The KD failed to suppress seizures in either of the tests involving suprathreshold stimulation (MMT and MES), although there was a significant increase in latency in the MMT test." | 1.32 | The effect of the 'classic' ketogenic diet on animal seizure models. ( Chow, C; Cunnane, S; McIntyre Burnham, W; Thavendiranathan, P, 2003) |
| "Seizures were terminated 30min later by ketamine (50mg/kg, i." | 1.32 | NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility. ( Sasaki-Adams, DM; Stafstrom, CE, 2003) |
| "We suggest that the seizure-induced decrease of sialidasic activity may not modify the number of sialic acid molecules bound to gangliosides in cell membranes, as compared to areas of increased activity, that may decrease them." | 1.32 | Neuraminidase activity in different regions of the seizing epileptic and non-epileptic brain. ( Ayala, J; Boyzo, A; Gutiérrez, R; Hernández-R, J, 2003) |
| "No spontaneous seizures occurred and no EEG differences were observed between the genotypes in drug naïve mice." | 1.32 | Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor. ( Berkovic, SF; Drago, J; Finkelstein, DI; Horne, MK; McColl, CD; Wong, JY, 2003) |
| "The role of brain histamine on seizure development of pentylenetetrazol (PTZ)-induced kindling was examined in H(1)-receptor gene knockout (H(1)KO), histidine decarboxylase-deficient (HDC(-/-)) and mast cell-deficient (W/W(v)) mice." | 1.32 | Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice. ( Chen, Z; Iinuma, K; Izadi Mobarakeh, J; Li, Z; Ohtsu, H; Sakurai, E; Watanabe, T; Yanai, K, 2003) |
| "Latency and incidence of a clonic seizure were recorded." | 1.32 | Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. ( Ahmadiani, A; Mandgary, A; Sayyah, M, 2003) |
| "Our proposed algorithm for seizure prediction is based on the principle that seizure build-up is always preceded by constantly changing bursting levels." | 1.32 | Prediction of PTZ-induced seizures using wavelet-based residual entropy of cortical and subcortical field potentials. ( Al-Nashash, H; Mirski, MA; Patel, CB; Paul, JS; Sherman, DL; Zhang, N; Ziai, WC, 2003) |
| "Seizure activity was observed and seizure patterns and convulsion times were recorded." | 1.32 | Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats. ( Ates, N; Ilbay, G; Sahin, D, 2003) |
| "Hypoosmolar treatment (water intoxication) was performed by the intraperitoneal administration of distilled water to a volume of 10% of the body weight; Six groups of rats were studied." | 1.32 | Influence of hypoosmolality on the blood-brain barrier permeability during epileptic seizures. ( Kaya, M; Küçük, M; Oztaş, B; Tuğran, N, 2003) |
| "Epileptic seizures originating from the limbic system have been shown to stimulate the proliferation rate of granule cell precursors in the adult brain, but it is not clear if other type(s) of seizures have the similar effects." | 1.32 | Dentate granule cell neurogenesis after seizures induced by pentylenetrazol in rats. ( Huang, YG; Jiang, W; Rao, ZR; Wan, Q; Wang, WD; Zhang, X; Zhang, ZJ, 2003) |
| "With pentylenetetrazol (PTZ) induced seizures pre-treated by CBZ, or SR-3, both CBZ and SR-3 were equally effective in providing seizure control and both were superior to the saline control." | 1.32 | Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). ( Mostofsky, DI; Rabinovitz, S; Yehuda, S, 2004) |
| "Third, forebrain seizures were induced in genetically epilepsy-prone rats (GEPRs) by microinfusion of bicuculline into the area tempestas (AT), while brainstem seizures in GEPRs were induced by audiogenic stimulation." | 1.32 | Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats. ( Browning, RA; Clough, RW; Eells, JB; Jobe, PC, 2004) |
| " This study was designed to assess the antiepileptic activity of aspirin and to investigate the potentiation of its activity in combination with a subconvulsive dose of lamotrigine." | 1.32 | Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice. ( Anuradha, K; Pandhi, P; Tandon, M, 2003) |
| "The inhibitory effects of BmK IM on seizures caused by pentylenetetrazol might depend on reductions in the release of presynaptic glutamate via the blocking of Na+ channels." | 1.32 | Inhibitory effects of recombinant neurotoxin BmK IM on seizures induced by pentylenetetrazol in Rats. ( He, X; Li, W; Liu, H; Peng, F; Zeng, X; Zhang, J, 2003) |
| "In the early seizure developmental process, both NR1 and NR2A were markedly increased in the cortex, and NR1 was significantly increased in the hippocampus." | 1.32 | Spatiotemporal changes of the N-methyl-D-aspartate receptor subunit levels in rats with pentylenetetrazole-induced seizures. ( Chen, Z; Luo, JH; Xu, AJ; Xu, SJ; Zhang, LS; Zhu, LJ, 2004) |
| "In models of complex partial seizures like the hippocampal stimulation and the amygdala kindling in rats, flunarizine showed only a moderate activity." | 1.32 | Anticonvulsant profile of flunarizine and relation to Na(+) channel blocking effects. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R, 2004) |
| "The alterations in clonic seizure threshold, induced by pentylenetetrazole, following the induction of intestinal inflammation by the administration of two consecutive daily oral doses of croton oil, was evaluated in mice." | 1.32 | Intestinal inflammation alters the susceptibility to pentylenetetrazole-induced seizure in mice. ( Bahadori, M; Dehpour, AR; Demehri, S; Homayoun, H; Honar, H; Riazi, K, 2004) |
| "In PTZ-induced seizure, the intraperitoneally injection of thymoquinone with doses of 40 and 80 mg/kg, prolonged the onset of seizures and reduced the duration of myoclonic seizures." | 1.32 | Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. ( Hosseinzadeh, H; Parvardeh, S, 2004) |
| "In PTZ-induced convulsions, the highest dose of agmatine (100 mg/kg) increased the seizure onset time and decreased percent survival." | 1.32 | Effect of agmatine on electrically and chemically induced seizures in mice. ( Aricioglu, F; Berkman, K; Kan, B; Korcegez, E; Yillar, O, 2003) |
| "Latency of the first seizure was significantly increased and its intensity reduced at the same doses, whereas the duration of the first seizure significantly decreased with doses of 20 mg/kg in most of the kynurenines tested." | 1.32 | Effects of some synthetic kynurenines on brain amino acids and nitric oxide after pentylenetetrazole administration to rats. ( Acuña-Castroviejo, D; Bikjdaouene, L; Camacho, E; De Dios Luna, J; Escames, G; Espinosa, A; Ferrer, JM; Gallo, MA; León, J, 2004) |
| "In PTZ kindled rats, convulsions produced changes in CaMKII Thr(286) phosphorylation and distribution in the same direction and of similar magnitude as after the acute convulsion, but lasting for a much longer time." | 1.32 | Prolonged changes in Ca2+/calmodulin-dependent protein kinase II after a brief pentylenetetrazol seizure; potential role in kindling. ( Dong, Y; Rosenberg, HC, 2004) |
| "In the second experiment, seizures were elicited in experimentally naive mice using 50mg/kg of PTZ once daily for 7 days." | 1.32 | MAO(A) knockout mice are more susceptible to seizures but show reduced epileptogenesis. ( Dyck, RH; Radford, KS; Seif, I; Teskey, GC, 2004) |
| "Experimental seizure models can be employed to identify potentially useful combinations for subsequent clinical evaluation." | 1.32 | Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. ( Brodie, MJ; Butler, E; Sills, GJ; Thompson, GG, 2004) |
| "The kindling seizure was induced by ip injection with subconvulsant dose of pentylenetetrazole every 48 h." | 1.32 | [Effect of alahistidine on brain histamine content and seizure development]. ( Chen, Z; Hu, WW; Jin, CL; Sakurai, E; Xu, LS; Yanai, K, 2004) |
| "It remains unclear whether the seizures result from aberrant neuronal placement, disruption of intrinsic properties of neurons, or both." | 1.32 | Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. ( Braden, AL; Caldwell, GA; Caldwell, KA; Locke, CJ; Williams, SN, 2004) |
| "Convulsions are common complications of shigellosis in children." | 1.32 | Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures. ( Ashkenazi, S; Chrousos, GP; Ovadia, H; Weizman, A; Yuhas, Y, 2004) |
| "increases seizure susceptibility." | 1.32 | Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia). ( Altrup, U; Joschko, A; Ure, A, 2004) |
| "Regarding the seizure-modulating properties of both classes of receptors, the present study examined the possibility of a functional interaction between these receptors." | 1.32 | The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hajrasouliha, AR; Homayoun, H; Moezi, L; Sadeghipour, H; Samini, M; Shafaroodi, H; Tavakoli, S, 2004) |
| "In the maximal electroshock-induced seizure test (MES), this compound had ED50 values of 108 mg/kg in rats and 115 mg/kg in mice." | 1.32 | Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives. ( Bialer, M; Sobol, E; Yagen, B, 2004) |
| "These results show that a brief seizure caused a decline in CREB expression up to 24 h later." | 1.32 | Decreased expression of brain cAMP response element-binding protein gene following pentylenetetrazol seizure. ( Lee, J; Li, F; Pi, X; Rosenberg, HC, 2004) |
| "Seizures have been shown to promote the proliferation of granule cell precursors in the adult brain, but the underlying mechanisms remain largely unknown." | 1.32 | Ionotropic glutamate receptor antagonists inhibit the proliferation of granule cell precursors in the adult brain after seizures induced by pentylenetrazol. ( Huang, YG; Jiang, W; Wolfe, K; Xiao, L; Zhang, X; Zhang, ZJ, 2004) |
| "Reports suggest that Alzheimer's disease (AD) patients show a high life-time prevalence of seizure-like disorders." | 1.32 | Increased seizure threshold and severity in young transgenic CRND8 mice. ( Del Vecchio, RA; Gold, LH; Hyde, LA; Novick, SJ; Wong, G, 2004) |
| "Epileptic seizures have been shown to increase the proliferation of granule cell precursors in the adult brain, but the underlying mechanisms remain largely unknown." | 1.32 | Effects of nitric oxide on dentate gyrus cell proliferation after seizures induced by pentylenetrazol in the adult rat brain. ( Huang, YG; Jiang, W; Wang, JC; Xiao, L; Zhang, X, 2004) |
| "Thus, Zac1 is highly induced in the seizure models that generate strong neuronal stimulation and/or extensive cell damage (cell death), reinforcing its putative role in the control of the cell cycle and/or apoptosis." | 1.32 | Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation. ( Auladell, C; Bellmann, A; Domínguez, MI; Ferrer, I; Journot, L; Valente, T, 2004) |
| "In PTZ seizure model Kyo and its analogues exerted strong inhibition on seizure intensity compared with control group." | 1.32 | Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures. ( Bocheva, AI; Dzambazova-Maximova, EB, 2004) |
| "Epilepsy is one of the most common but genetically complex neurological disorders in humans." | 1.32 | Genetic and phenotypic analysis of seizure susceptibility in PL/J mice. ( Ernest, S; Frankel, WN; Friedman, L; Gallaugher, L; Kitami, T; Nadeau, JH, 2004) |
| "When tested against PTZ-induced convulsions, PEA protected against tonic convulsions and prolonged the latency between convulsive episodes." | 1.32 | Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid. ( Corcoran, ME; Saucier, DM; Sheerin, AH; Zhang, X, 2004) |
| "After pentylenetetrazol-induced seizures: (i) S100B values increased from 10 to 30 min, returning to control levels at 24 h; NSE levels presented a biphasic increase: an increase at 10 to 30 min returning to control levels, and again at 240 min followed by a decline at 24 h; (ii) nucleotidase activities increased from 10 min, returning to control levels at 240 min; (iii) guanosine and inosine levels increased exclusively after 30 min." | 1.32 | Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. ( Casali, EA; Lara, DR; Leke, R; Oses, JP; Portela, LV; Sarkis, JJ; Schmidt, AP; Souza, DO; Wofchuk, S, 2004) |
| "2 Carcinine was highly selective for the histamine H3 receptor over H1 or H2 receptor (Ki (microM)=0." | 1.32 | Pharmacological effects of carcinine on histaminergic neurons in the brain. ( Chen, Z; Hu, W; Jin, C; Kato, M; Kiso, Y; Sakurai, E; Watanabe, T; Wei, E; Yanai, K, 2004) |
| "Pretreatment with letrozole, an aromatase inhibitor that blocks the conversion of testosterone to 17beta-estradiol, significantly inhibited testosterone-induced exacerbation of seizures." | 1.32 | Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol. ( Reddy, DS, 2004) |
| " The present study examined the effect of acute and chronic administration of lithium chloride (LiCl) on morphine's biphasic modulation of susceptibility to pentylenetetrazole (PTZ)-induced clonic seizure in mice." | 1.32 | Lithium inhibits the modulatory effects of morphine on susceptibility to pentylenetetrazole-induced clonic seizure in mice: involvement of a nitric oxide pathway. ( Dehghani, M; Dehpour, AR; Demehri, S; Ebrahimkhani, MR; Gaskari, SA; Homayoun, H; Honar, H; Rashidi, N; Riazi, K; Vafaie, K, 2004) |
| "Progestins can have profound effects on seizure processes." | 1.32 | Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model. ( Frye, CA; Rhodes, ME, 2004) |
| "Susceptibility to PTZ-induced convulsive seizures was significantly higher in -/- versus +/+ mice." | 1.31 | Behavior and physiology of mice lacking the GABAA-receptor delta subunit. ( Banerjee, PK; Homanics, GE; Li, Z; Mihalek, RM; Olsen, RW; Spigelman, I, 2002) |
| "gummosa protected mice against tonic convulsions induced by maximal electroshock (the median effective dose [ED(50)]=198." | 1.31 | Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. ( Kamalinejad, M; Mandgary, A; Sayyah, M, 2002) |
| " In dose-response studies, DOC suppressed MMT seizures with an ED(50) of about 5 mg/kg (sc)." | 1.31 | Dose-, time-, age-, and sex-response profiles for the anticonvulsant effects of deoxycorticosterone in 15-day-old rats. ( Burnham, WM; Edwards, HE; Vimal, S, 2002) |
| "All rats given PTZ developed recurrent seizures." | 1.31 | Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures. ( Holmes, GL; Huang, LT; Hung, PL; Lai, MC; Liou, CW; Wang, CL; Wang, TJ; Yang, CH; Yang, SN, 2002) |
| " Usually, the slope of the dose-response lines for RWJ-51204 was more shallow than the full agonist anxiolytics but steeper than partial agonists in efficacy tests but typically shallow in tests for central nervous system side effects." | 1.31 | 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. ( Carter, AR; Cheo-Isaacs, CT; Crooke, JJ; DeLuca, S; DeVine, A; Dubinsky, B; Hochman, C; Jordan, AD; Reitz, AB; Rosenthal, DI; Shank, RP; Vaidya, AH, 2002) |
| "The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats." | 1.31 | Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats? ( Haugvicová, R; Kubová, H; Mares, P, 2002) |
| "With the use of well defined animal seizure models, Con-R was found to possess an anticonvulsant profile superior to that of ifenprodil and dizocilpine (MK-801)." | 1.31 | In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. ( Abogadie, FC; Armstrong, H; Cruz, LJ; Donevan, SD; Hollmann, M; McCabe, RT; Olivera, BM; Paarmann, I; Rivier, JE; Torres, J; White, HS, 2000) |
| "The present study investigated the seizure-suppressing effects of systemic epinephrine." | 1.31 | Seizure suppression by systemic epinephrine is mediated by the vagus nerve. ( Handforth, A; Krahl, SE; Senanayake, SS, 2000) |
| "Seizures were induced by single administration of PTZ, which was associated with an increase in levels of NO metabolites (NOx) in the hippocampus." | 1.31 | Involvement of nitric oxide in pentylenetetrazole-induced kindling in rats. ( Han, D; Nabeshima, T; Nawa, H; Senzaki, K; Xiong, H; Yamada, K, 2000) |
| "In fact, the tests involving maximal seizures actually showed proconvulsant effects." | 1.31 | The MCT ketogenic diet: effects on animal seizure models. ( Burnham, WM; Cunnane, SC; Dell, C; Iracleous, C; Likhodii, SS; Mendonca, A; Musa, K; Thavendiranathan, P, 2000) |
| "Generalized tonic-clonic convulsions were induced on 2 consecutive days by pentylenetetrazol (PTZ) in immature rats (postnatal days 10 and 20), and hippocampal slices were prepared at different intervals post-injection." | 1.31 | Immature rat convulsions and long-term effects on hippocampal cholinergic neurotransmission. ( Carmant, L; Meilleur, S; Psarropoulou, C, 2000) |
| "Sensitivity to PTZ-induced seizures and lethality was not affected in mice with a history of repeated treatment with ganaxolone, diazepam, or valproate." | 1.31 | Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate. ( Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM, 2000) |
| "in untreated and in theophylline-treated male mice (50 mg/kg i." | 1.31 | Long-term theophylline treatment changes the effects of angiotensin II and adenosinergic agents on the seizure threshold. ( Georgiev, V; Kambourova, T; Tchekalarova, J, 2000) |
| "On the other hand, STT had no effect on convulsions in fully pentylenetetrazol-kindled mice." | 1.31 | Effect of shitei-to, a traditional Chinese medicine formulation, on pentylenetetrazol-induced kindling in mice. ( Fukuda, T; Minami, E; Nomoto, M; Shibata, H, 2000) |
| "Potentiation of convulsions by BSO treatment was recovered by supplying GSH (10 nmol, i." | 1.31 | The possible role of endogenous glutathione as an anticonvulsant in mice. ( Abe, K; Nakanishi, K; Saito, H, 2000) |
| "Amnestic effects induced seizures were shown to depend on relationships between the intensity of learning and the intensity of seizures." | 1.31 | [Pharmacological reminder of the emotional condition facilitates the amnestic memory trace retrieval]. ( Bazian, AS; Getsova, VM; Orlova, NV, 2000) |
| "In contrast, PTZ induced seizure did not increase BDNF protein levels in either tissue." | 1.31 | Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus. ( Mack, KJ; Nanda, SA, 2000) |
| "Seizures are also often associated with tics and compulsions, which likewise involve cortical-limbic hyperactivity." | 1.31 | TS+OCD-like neuropotentiated mice are supersensitive to seizure induction. ( Burton, FH; Campbell, KM; McGrath, MJ; Veldman, MB, 2000) |
| "Compound 21 also effectively suppresses seizures induced in Swiss mice by maximal electroshock (MES) and pentylenetetrazole (PTZ)." | 1.31 | Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones. ( Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M, 2000) |
| "Sound induced convulsions in DBA/2 mice were dose-dependently inhibited by all compounds (administered intraperitoneal, i." | 1.31 | GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. ( Dalby, NO, 2000) |
| " GTCSs were suppressed by TGB in the adult and 25-day-old rats, and a U-shaped dose-response curve was outlined in these two groups." | 1.31 | Two different anticonvulsant actions of tiagabine in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Skutová, M; Suchomelová, L, 2000) |
| "However, after kindled seizures, GluRAs block the monosynaptic excitatory postsynaptic potential (EPSP) and isolate a monosynaptic inhibitory postsynaptic potential (IPSP), suggesting that mossy fibers release GABA." | 1.31 | Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system. ( Gutiérrez, R, 2000) |
| "The role of morphine-dependence on the seizure susceptibility has been evaluated with models of pentylenetetrazol (PTZ)-kindling and acute convulsions induced by PTZ, N-methyl-D-aspartic acid (NMDA), picrotoxin and caffeine in adult male rats." | 1.31 | Chemical kindling and seizure susceptibility in morphine dependent rats. ( Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M, 2000) |
| "Convulsions were followed by significant increase in the tail-flick latencies (TFL), at least for 30 min of the post-ictal period." | 1.31 | Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms. ( Castro-Souza, C; Coimbra, NC; Garcia-Cairasco, N; Herrero, CF; Nora, JE; Segato, EN; Tedeschi-Filho, W, 2001) |
| "Acute seizures of the same intensity did not induce these alterations." | 1.31 | Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol--induced seizures. ( Eraković, V; Laginja, J; Simonić, A; Varljen, J; Zupan, G, 2001) |
| "Behavioral seizure thresholds were determined by intravenous infusion of the proconvulsant, pentylenetetrazol (PTZ), on PD 31 or on PD 90." | 1.31 | Reduced seizure threshold and hippocampal cell loss in rats exposed to alcohol during the brain growth spurt. ( Bonthius, DJ; Bonthius, NE; Lothman, EW; Taggard, DA; Woodhouse, J, 2001) |
| "From that age onwards, the seizure threshold significantly decreased and reached a minimum at PN 220." | 1.31 | PTZ-induced seizures in rats: effects of age and strain. ( Chepurnov, SA; Chepurnova, NE; Klioueva, IA; van Luijtelaar, EL, 2001) |
| "These results suggest that NPY reduces seizures of hippocampal origin through activation of Y(5) receptors." | 1.31 | Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation. ( Benmaamar, R; Carnahan, J; Depaulis, A; Larmet, Y; Marescaux, C; Nadi, S; Reibel, S, 2001) |
| " The analyses of the dose-response curves indicated that females were more susceptible than males when the 50- and 60-mg/kg doses were used." | 1.31 | Sex differences in sensitivity to seizures elicited by pentylenetetrazol in mice. ( Manhães, AC; Medina, AE; Schmidt, SL, 2001) |
| "Thirty seconds after VNS onset, seizures were induced by pentylenetetrazol (PTZ), and seizure severity was measured." | 1.31 | Destruction of peripheral C-fibers does not alter subsequent vagus nerve stimulation-induced seizure suppression in rats. ( Handforth, A; Krahl, SE; Senanayake, SS, 2001) |
| "It also delayed the onset of seizures induced by isonicotinic acid hydrazide and strongly antagonized N-methyl-D-aspartate-induced turning behavior." | 1.31 | Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae). ( Bopelet, M; Bum, EN; Herrling, P; Jeker, A; Meyer, C; Olpe, HR; Portet, C; Rakotonirina, A; Rakotonirina, SV; Schmutz, M, 2001) |
| "Following cocaine-induced seizures, intense c-fos induction was observed in piriform cortex, amygdala, and hippocampus." | 1.31 | Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats. ( Keller, RW; Snyder-Keller, A, 2001) |
| "Nafimidone oxime was synthesized by the reaction of nafimidone and hydroxylamine hydrochloride." | 1.31 | Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities. ( Dalkara, S; Karakurt, A; Kendi, E; Ozalp, M; Ozbey, S; Stables, JP, 2001) |
| "The ED50 value of AML against clonic seizures induced by PTZ was 5." | 1.31 | Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures. ( Czuczwar, SJ; Kamiński, RM; Kleinrok, Z; Mazurek, M; Turski, WA, 2001) |
| "In general, DBH KO mice were much more seizure-sensitive than NPY KO mice and had normal NPY expression, demonstrating that an NPY deficiency did not contribute to the DBH KO seizure phenotype." | 1.31 | Genetic comparison of seizure control by norepinephrine and neuropeptide Y. ( Hohmann, JG; Miller, NS; Palmiter, RD; Pyati, U; Rust, NC; Szot, P; Weinshenker, D; White, SS, 2001) |
| "GAD expression is increased after seizures, and simultaneous glutamatergic and GABAergic neurotransmission from the mossy fibers to CA3 appears, supporting the hypothesis that GABA can be released from the mossy fibers." | 1.31 | Vesicular GABA transporter mRNA expression in the dentate gyrus and in mossy fiber synaptosomes. ( Gómez-Lira, G; Gutiérrez, R; Lamas, M, 2001) |
| "After kindled seizures, this enzyme is transiently overexpressed and simultaneous glutamatergic and GABAergic transmission in the mossy fiber projection occurs." | 1.31 | Activity-dependent expression of GAD67 in the granule cells of the rat hippocampus. ( Gutiérrez, R; Ramírez, M, 2001) |
| "Testosterone's (T) anti-seizure effects may be mediated in part by actions of its 5alpha-reduced metabolites." | 1.31 | Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase. ( Frye, CA; Harney, JP; Rhodes, ME; Walf, AA, 2001) |
| "PTZ-induced seizures were inhibited by three standard anticonvulsant drugs, but not by the group III selective mGluR agonist (R,S)-4-phosphonophenylglycine (PPG)." | 1.31 | Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. ( Burnashev, N; Bushell, TJ; Clarke, VR; Collett, VJ; Collingridge, GL; Duvoisin, RM; Flor, PJ; Gasparini, F; Hampson, DR; Klebs, K; Knoepfel, T; Kuhn, R; Portet, C; Rozov, A; Sansig, G; Schmutz, M; Schroeder, M; Shigemoto, R; van Der Putten, H; Zhang, C, 2001) |
| "During seizures, PCr and ATP decreased in mutants but not in wild-types." | 1.31 | Altered brain phosphocreatine and ATP regulation when mitochondrial creatine kinase is absent. ( Benzecry, JM; Holtzman, D; Kekelidze, T; Khait, I; Togliatti, A; Wieringa, B, 2001) |
| " In the subchronic experiments, rats were exposed to PCE at a dosage of 5 and 50 mg/kg in corn oil, 5 days per week for 8 weeks." | 1.31 | Behavioural effects of tetrachloroethylene exposure in rats: acute and subchronic studies. ( Chan, MH; Chen, HH; Fu, SH, 2002) |
| "In MES seizures significant protection was seen with aspirin 100 mg/kg where as higher dose of aspirin 500 mg/kg was required to elicit maximum protection against PTZ seizures." | 1.31 | Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice. ( Gupta, YK; Srivastava, AK, 2001) |
| "Pretreatment with ketoconazole significantly increased the percentage of animals with induced seizures in oestrus but not in dioestrus as compared to controls, probably through reduced progesterone levels." | 1.31 | Effects of ketoconazole on oestrus cycle and convulsant action of pentylenetetrazol in mice. ( Acevedo, X; Bustamante, D; Miranda, HF; Pesce, ME; Pinardi, G, 2001) |
| "Clinical seizures after venlafaxine treatment have occasionally been reported when the drug was used at very high doses or in combination with other medications." | 1.31 | Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats. ( Agustine, PE; Do Monte, FH; Lanziotti, VM; Russi, M; Santos, JG, 2002) |
| "Stress affects seizure susceptibility in animals and humans, but the underlying mechanisms are obscure." | 1.31 | Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. ( Reddy, DS; Rogawski, MA, 2002) |
| "Other childhood seizures are also responsive to ACTH." | 1.31 | The effects of ACTH and adrenocorticosteroids on seizure susceptibility in 15-day-old male rats. ( Burnham, WM; Edwards, HE; Vimal, S, 2002) |
| "TBM also inhibited seizures induced by pentylenetetrazol (PTZ), electrical kindling, and the combination of lithium sulfate and pilocarpine nitrate (Li-Pilo)." | 1.31 | Anticonvulsive activity of Butea monosperma flowers in laboratory animals. ( Chopde, CT; Kasture, SB; Kasture, VS, 2002) |
| " Moreover, wv/- mice exhibit much milder cerebellar abnormalities than wv/wv mice, indicating a dosage effect of the GIRK2 G156S mutation." | 1.30 | Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. ( Duncan, SA; Jan, LY; Liao, YJ; Signorini, S; Stoffel, M, 1997) |
| "Alaproclate and GEA-857 antagonized seizures induced by NMDA, 200 mg/kg subcutaneously at doses similar to those antagonizing the harmaline- and NMDA-induced elevation of cerebellar cGMP." | 1.30 | NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. ( Hu, PS; Ross, SB, 1997) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was inhibited by pretreatment with MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate), 7-chlorokynurenic acid and ifenprodil." | 1.30 | Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| "The interstrain differences in seizure susceptibility are probably determined by SB mice nervous system traits rather than by differences in the particular neurochemical trait." | 1.30 | Pentylenetetrazol and strychnine convulsions in brain weight selected mice. ( Bogdanov, NN; Poletaeva, II; Popova, NV, 1997) |
| " We demonstrate that jerky has a dosage-sensitive function (haploinsufficiency) in brain and that this sensitivity to reduced jerky dosage could explain the occurrence of seizures in hemizygotes." | 1.30 | Sensitivity to jerky gene dosage underlies epileptic seizures in mice. ( Donovan, GP; Gal, J; Gudas, LJ; Harden, C; Ho, L; Sibille, E; Toth, M; Trifiletti, R, 1997) |
| "Hippocampal area was unaffected." | 1.30 | Dextromethorphan ameliorates effects of neonatal hypoxia on brain morphology and seizure threshold in rats. ( Baggs, R; Guillet, R; Laroia, N; McBride, L, 1997) |
| "AGV also induced increase of seizure intensity at doses of 0." | 1.30 | Effects of [arginine8, glycine-OH9]-vasopressin on pentylenetetrazol seizures in mice. Interaction with adrenaline. ( Georgiev, VP; Kambourova, TS; Lambadjieva, ND, 1997) |
| " It was reported to potentiate GABA-mediated chloride current in cultured cells with a moderate intrinsic activity and a biphasic dose-response relationship." | 1.30 | Anxiolytic-like effects of PNU-101017, a partial agonist at the benzodiazepine receptor. ( Carter, DB; Franklin, SR; Jacobsen, EJ; Needham, LM; Sethy, VH; Tang, AH; Von Voigtlander, PF, 1997) |
| "alprazolam and ketamine, was tested in two types of seizure activity." | 1.30 | Effect of alprazolam and ketamine on seizures induced by two different convulsants. ( Herink, J, 1997) |
| " The fact that long term administration of deprenyl was needed to produce its anticonvulsant effect may indicate that the anticonvulsant effect of deprenyl may be due to changes in levels of certain endogenous compounds or down or up-regulation of relevant receptor/effector units." | 1.30 | The anticonvulsant effect of deprenyl on pentylenetetrazol-induced seizures in Lewis rats. ( Afargan, M; Backon, J; Hoffman, A; Perlstein, I, 1997) |
| "In Nigeria, convulsion, especially in children, is managed by traditional healers employing plant decoctions." | 1.30 | Experimental study of the anticonvulsant plants used for treatment of infantile convulsion in Nigeria. ( Akah, PA; Gamaniel, KS; Nwambie, AI; Wambebe, C, 1997) |
| "rats with a pentylenetetrazole-induced seizure score of 3 or more on a seizure scale ranging from 0 to 6) and death rate compared with those obtained for rats pre-treated with an equivalent intraperitoneal dose (140 mg kg-1) of acepifylline ('equivalent dose' referred to here denotes the theophylline content of the two preparations)." | 1.30 | A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1997) |
| "This ethanol-induced increase in seizure rating was unaffected by carbamazepine (30 mg kg(-1)) but significantly reduced at a higher concentration (130 mg kg(-1))." | 1.30 | Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro. ( Boden, PR; Field, MJ; Ibbotson, T, 1997) |
| "To determine whether seizures affect GABA(A)-receptor gene transcription in vivo, a transgenic mouse line carrying a lacZ-fusion gene driven by GABA(A)-receptor delta-subunit promoter and upstream sequences was subjected to pentylenetetrazol (PTZ)-induced seizures." | 1.30 | Activation of the GABA(A)-receptor delta-subunit gene promoter following pentylenetetrazole-induced seizures in transgenic mice. ( Crestani, F; Fritschy, JM; Lüscher, B; Penschuck, S, 1997) |
| "Glycine is a small neutral amino acid exhibiting weak anticonvulsant activities in vivo." | 1.30 | N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants. ( Geurts, M; Lambert, DM; Poupaert, JH; Scriba, GK, 1998) |
| "Pentylenetetrazol (PTZ) seizure threshold was determined in the rat during recovery from anesthesia induced by intravenous administration of propofol (20 mg/kg) or thiopentone (30 mg/kg)." | 1.30 | Pentylenetetrazol seizure threshold in the rat during recovery phase from propofol and thiopentone induced anesthesia. ( Hasan, Z, 1997) |
| "Isatin was found to induce a dose-related effect on PTZ and 3MPA convulsions." | 1.30 | Dose-related proconvulsant and anticonvulsant activity of isatin, a putative biological factor, in rats. ( Bhattacharya, SK; Chakrabarti, A, 1998) |
| "The increase in seizure sensitivity of repeatedly withdrawn mice was prevented by treatment with the NMDA receptor antagonist CGP 39551 (20 mg/kg, i." | 1.30 | Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist. ( Dunworth, SJ; Stephens, DN, 1998) |
| "The decrease in the seizure threshold for pentylenetetrazole in diazepam-withdrawn mice was not significantly affected by L-arginine (50 and 100 microg/mouse, i." | 1.30 | Role of nitric oxide in the hypersusceptibility to pentylenetetrazole-induced seizure in diazepam-withdrawn mice. ( Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y, 1998) |
| "Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant." | 1.30 | Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. ( Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV, 1998) |
| " Both effects exhibited a tendency to a U-shaped dose-response curve." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "Forced restraint stress and PTZ-induced seizures generated c-fos mRNA expression of distinct intensities, but in similar brain regions, including the hippocampus, the amygdala, the piriform cortex, the paraventricular hypothalamic nucleus, the habenula, and parts of the cerebral cortex." | 1.30 | Differential expression of c-fos mRNA and Fos protein in the rat brain after restraint stress or pentylenetetrazol-induced seizures. ( Del Bel, EA; Garcia-Cairasco, N; Graeff, FG; Guimarães, FS; Silveira, MC, 1998) |
| "At P21, l-Arg improved the outcome of seizures while LNA had no effect." | 1.30 | Age-dependent regulation of seizure activity by nitric oxide in the developing rat. ( Marescaux, C; Nehlig, A; Pereira de Vasconcelos, A, 1998) |
| "at its CD97 of 90 mg/kg) convulsions." | 1.30 | GYKI 52466 [1-(4-aminophenyl)-4-methoxy-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] and the anticonvulsive activity of conventional antiepileptics against pentetrazol in mice. ( Czuczwar, SJ; Gasior, M; Kamiński, R; Kleinrok, Z; Kozicka, M; Ossowska, G; Pietrasiewicz, T, 1998) |
| "Adenosine has been shown to play a significant role as a modulator of neuronal activity in convulsion disorders, acting as an endogenous anticonvulsant agent." | 1.30 | Time development and regional distribution of [3H]nitrobenzylthioinosine adenosine uptake site binding in the mouse brain after acute Pentylenetetrazol-induced seizures. ( Angelatou, F; Pagonopoulou, O, 1998) |
| "SL 75 102 suppressed generalized tonic-clonic seizures in adult rats and restricted the tonic phase of these seizures in rat pups." | 1.30 | Anticonvulsant effect of SL 75 102 in adult and immature rats. ( Haugvicová, R; Kubová, H; Mares, P, 1997) |
| "Seizures were induced by repetitive injections of subconvulsive doses of PTZ." | 1.30 | Mapping of neuronal networks underlying generalized seizures induced by increasing doses of pentylenetetrazol in the immature and adult rat: a c-Fos immunohistochemical study. ( André, V; Marescaux, C; Motte, JE; Nehlig, A; Pineau, N, 1998) |
| "Pentylenetetrazol-induced seizure produces less disruption of the blood-brain barrier in right cerebral hemisphere than in left cerebral hemisphere in female rats." | 1.30 | Asymmetrical changes in blood-brain barrier permeability during pentylenetetrazol-induced seizures and in acute hypertension. ( Oztaş, B, 1998) |
| "were studied on seizures induced by subcutaneous injection of pentylenetetrazole (PTZ), a widely used antiepileptic screening test believed to model generalized myoclonic seizures." | 1.30 | Antiepileptic effects of NPY on pentylenetetrazole seizures. ( Woldbye, DP, 1998) |
| "Chemically kindled clonic seizures were observed in 100% of TMPP or FG-7142 and 50% of PTZ treated rats by the thirtieth dosing." | 1.30 | Repeated exposure to trimethylolpropane phosphate induces central nervous system sensitization and facilitates electrical kindling. ( Cassell, J; Lin, J; Nordholm, AF; Ritchie, GD; Rossi, J, 1998) |
| "In the maximal electroshock seizure threshold test, clobenpropit dose-dependently raised the electroconvulsive threshold for tonic (hindlimb extension) seizures, but a significant increase of about 15% was determined only at the high dose of 40 mg/kg i." | 1.30 | Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice. ( Fischer, W; van der Goot, H, 1998) |
| "Whereas neonatal seizures are a predictor of adverse neurological outcome, there is controversy regarding whether seizures simply reflect an underlying brain injury or can cause damage." | 1.30 | Consequences of neonatal seizures in the rat: morphological and behavioral effects. ( Ben-Ari, Y; Chevassus-Au-Louis, N; Gairsa, JL; Holmes, GL, 1998) |
| "F2 intercross progeny, derived from seizure-sensitive DBA/2J (D2) and seizure-resistant C57BL/6J (B6) inbred strains of mice, were tested for their sensitivity to the seizure-inducing effect of pentylenetetrazol (PTZ), a gamma-aminobutyric acid (GABA) receptor antagonist." | 1.30 | Genotyping microsatellite polymorphisms by agarose gel electrophoresis with ethidium bromide staining: application to quantitative trait loci analysis of seizure susceptibility in mice. ( Ballas, C; Berrettini, WH; Buono, RJ; Ferraro, TN; Golden, GT; Mulholland, N; Schill, JF; Smith, GG, 1998) |
| "Rats that received twice daily seizures on P10-P25 had an increase in dentate granule cells." | 1.30 | Mossy fiber sprouting after recurrent seizures during early development in rats. ( Ben-Ari, Y; Chevassus-Au-Louis, N; Holmes, GL; Sarkisian, M, 1999) |
| " The pharmacokinetics of the active compounds was studied in dogs, which is a common animal model for a comparative crossover pharmacokinetic studies." | 1.30 | Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives. ( Bialer, M; Dagan, A; Sussan, S, 1999) |
| "Neurologic manifestations, mainly convulsions, are the most frequent extraintestinal complications of shigellosis." | 1.30 | Involvement of tumor necrosis factor alpha and interleukin-1beta in enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae. ( Ashkenazi, S; Kaminsky, E; Shulman, L; Vanichkin, A; Weizman, A; Yuhas, Y, 1999) |
| " Studies on retrobenzamides in mice dosed intraperitoneally point out a good anticonvulsant potential in the MES test for the amino derivatives (N-(aminophenyl)benzamides) and moderate activity for corresponding "nitro" derivatives." | 1.30 | Design, anticonvulsive and neurotoxic properties of retrobenzamides. N-(Nitrophenyl)benzamides and N-(aminophenyl)benzamides. ( Bourhim, M; Poupaert, JH; Stables, JP; Vallée, L; Vamecq, J, 1999) |
| "Anticonvulsant drugs reduced the seizure manifestations and partially prevented the NO generation enhancement." | 1.30 | [Nitric oxide in the rat cerebral cortex in seizure models: potential ways of pharmacological modulation]. ( Bashkatova, VG; Mikoian, VD; Narkevich, VB; Raevskiĭ, KS; Vanin, AF; Vitskova, GIu, 1998) |
| " Pharmacokinetic analysis of several compounds indicated excellent oral bioavailability and a reasonable half-life in rats." | 1.30 | Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. ( Belonga, KL; Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; Mickelson, JW; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; TenBrink, RE; VonVoigtlander, PF; Zhong, WZ, 1999) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was significantly suppressed by intracerebroventricular (i." | 1.30 | Role of metabotropic glutamate receptors in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal. ( Misawa, M; Shimizu, N; Soma, M; Suzuki, T; Tsuda, M, 1999) |
| "Convulsions were induced in rats by a single injection of pentylenetetrazol (PTZ) and [3H]L-2-amino-4-phosphonobutyrate ([3H]L-AP4) in vitro receptor autoradiography was used to evaluate the effects on the expression of group III metabotropic glutamate receptors." | 1.30 | Pentylenetetrazol-induced seizures increase [3H]L-2-amino-4-phosphonobutyrate binding in discrete regions of the rat brain. ( Thomsen, C, 1999) |
| "Maximal protection against convulsions was effectively demonstrated by 8-(n-hexylthio)paeonimetabolin I (8) and 8-benzoylthiopaeonimetabolin I (18) at doses of 0." | 1.30 | Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis. ( Abdel-Hafez, AA; El-Gendy, MA; Hattori, M; Mahfouz, NM; Meselhy, MR; Mohamed, TA; Murakami, Y; Nakamura, N; Watanabe, H, 1999) |
| "Pregnenolone sulfate (PS) is an endogenous neurosteroid known to antagonize GABA(A) receptor-mediated inhibitory responses and potentiate NMDA receptor-mediated excitatory responses in vitro." | 1.30 | Convulsant actions of the neurosteroid pregnenolone sulfate in mice. ( Juhng, KN; Kirkby, RD; Kokate, TG; Llamas, J; Rogawski, MA; Yamaguchi, S, 1999) |
| "Latencies were used to calculate a seizure score that was used for quantitative mapping." | 1.30 | Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. ( Ballas, C; Berrettini, WH; Buono, RJ; Ferraro, TN; Golden, GT; Mulholland, N; Schill, J; Schork, NJ; Smith, GG; St Jean, P, 1999) |
| "Besides the seizure development, the kindling induced enhancement of glutamate binding and the kindling-induced learning deficit were examined." | 1.30 | Involvement of delta-opioid receptors in pentylenetetrazol kindling development and kindling-related processes in rats. ( Becker, A; Grecksch, G; Höllt, V; Schroeder, H, 1999) |
| "Epileptic seizures are associated with increases in hippocampal excitability, but the mechanisms that render the hippocampus hyperexcitable chronically (in epilepsy) or acutely (in status epilepticus) are poorly understood." | 1.30 | Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. ( Basbaum, AI; Cao, Y; Liu, H; Mazarati, AM; Sankar, R; Wasterlain, CG, 1999) |
| "The mean convulsion scores were 0." | 1.30 | Role of nitric oxide in the enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae. ( Ashkenazi, S; Balter-Seri, J; Kaminsky, E; Nofech-Mozes, Y; Weizman, A; Yuhas, Y, 1999) |
| "Results indicate that seizure threshold was significantly elevated with increasing ketogenic ratios (i." | 1.30 | Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat. ( Bough, KJ; Chen, RS; Eagles, DA, 1999) |
| " In the mouse pentylenetetrazole (PTZ) convulsive model, intravenous pretreatment with cefazolin (800 mg/kg) or imipenem (200 mg/kg) shifted the dose-response curve of PTZ (i." | 1.30 | Low convulsive activity of a new carbapenem antibiotic, DK-35C, as compared with existing congeners. ( Cho, JH; Jin, C; Jung, I; Kim, DH; Kim, M; Ku, HJ; Oh, CH; Yook, J, 1999) |
| "Pentylenetetrazole treatment in young rats resulted in a robust induction of microtubule-associated protein 1B immunoreactivity in the granule cells of the dentate gyrus and in layers II/III of the entorhinal cortex, but also produced a large decrease in the retrosplenial cortex." | 1.30 | Anomalous expression of microtubule-associated protein 1B in the hippocampus and cortex of aged rats treated with pentylenetetrazole. ( Fischer, B; Kessler, C; Neubig, R; Platt, D; Popa-Wagner, A; Schmoll, H, 1999) |
| "Generalized tonic-clonic seizures were suppressed in all age groups, the three youngest groups being more sensitive than older animals." | 1.30 | The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Mikulecká, A, 1999) |
| "In PTZ-induced seizures, L-arginine significantly decreased the dose of PTZ required to produce a threshold seizure, while NOARG increased it." | 1.30 | Role of nitric oxide in electroshock and pentylenetetrazole seizure threshold in rats. ( Balakrishnan, S; Nidhi, G; Pandhi, P, 1999) |
| "Minimal, predominantly clonic seizures with preserved righting ability were reliably induced by pentylenetetrazol and suppressed by clobazam in rats aged 18 days or more." | 1.30 | Antipentylenetetrazol action of clobazam in developing rats. ( Haugvicová, R; Kubová, H; Mares, P, 1999) |
| "All animals were tested three times for seizure threshold, and were then decapitated and the brains removed for analysis of the amino acids." | 1.30 | Effects of ammonia on pentylenetetrazole-induced seizure threshold. ( Arikan, K; Coskun, T; Guvener, B; Oran, O, 1999) |
| "Thus, recurrent limbic seizures activate both prodynorphin and proenkephalin genes, whereas generalized clonic-tonic seizures seem to decrease the prodynorphin and increase the proenkephalin gene expression in the dentate gyrus." | 1.29 | Seizure related changes in the regulation of opioid genes and transcription factors in the dentate gyrus of rat hippocampus. ( Kaczmarek, L; Kamińska, B; Lasoń, W; Lukasiuk, K; Nowicka, DZ; Przewłocka, B; Przewłocki, R, 1995) |
| " This anti-MES activity is achieved with nontoxic doses, with the optimal effect recorded in rats dosed orally with anti-MES ED50 and protective index (PI) values of 25." | 1.29 | Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide and prototype antiepileptic drugs in mice and rats. ( Bailleux, V; Hamoir, G; Nuyts, JP; Poupaert, JH; Stables, JP; Vallée, L; Vamecq, J, 1995) |
| " The anticonvulsant profile of chronic administration of BR-16A (100 and 500 mg/kg) was studied in this model of epilepsy." | 1.29 | Pentylenetetrazol-induced kindling in animals: protective effect of BR-16A. ( George, B; Kulkarni, SK, 1995) |
| "Withdrawal Seizure-Prone (WSP) and -Resistant (WSR) mice, which were selectively bred for severe (WSP) or mild (WSR) handling-induced convulsions (HICs) following chronic ethanol inhalation, were found to differ in sensitivity to the anticonvulsant effects of the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one (3 alpha,5 alpha-P." | 1.29 | Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice. ( Crabbe, JC; Finn, DA; Roberts, AJ, 1995) |
| "There were also gender differences in seizure susceptibility." | 1.29 | Neonatal caffeine exposure and seizure susceptibility in adult rats. ( Dunham, L; Guillet, R, 1995) |
| "In all experiments, the PTZ seizure threshold was repeatedly determined in individual rats with chronically implanted catheters at daily intervals." | 1.29 | Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats. ( Hönack, D; Löscher, W, 1995) |
| "Cypermethrin pretreatment potentiated the actions of pentobarbital and pentylene-tetrazole as evidenced by an increase in pentobarbital induced hypnosis and duration of pentylene-tetrazole induced chemoshock seizures." | 1.29 | Pharmacodynamic interactions of cypermethrin and centrally acting drugs in mice. ( Kanwar, RS; Varshneya, C, 1995) |
| "PTZ-induced convulsions were partly antagonized by the GVG treatment." | 1.29 | The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments. ( Sayin, U; Timmerman, W; Westerink, BH, 1995) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 1.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| "This was indicated by a higher mean convulsion score, increased number of mice responding with convulsions, and induction of seizures in animals pretreated with a subepileptic dose of pentylenetetrazol." | 1.29 | An animal model for the study of neurotoxicity of bacterial products and application of the model to demonstrate that Shiga toxin and lipopolysaccharide cooperate in inducing neurologic disorders. ( Ashkenazi, S; Dinari, G; Weizman, A; Yuhas, Y, 1995) |
| ", significantly lowered the convulsive threshold of pentylenetetrazol (PTZ) in mice and shifted the dose-response curve of PTZ." | 1.29 | Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem. ( Day, IP; Goudie, J; Nishiki, K; Williams, PD, 1995) |
| " Since several pathophysiological phenomena are common for both ischemia and seizures, we have explored the effect of acute and chronic administration of the adenosine A3 receptor selective agonist IB-MECA (N6-(3-iodobenzyl) adenosine-5'-N-methylcarboxamide) prior to seizures induced by N-methyl-D-aspartate (NMDA), pentamethylenetetrazole, or electric shock." | 1.29 | The effects of adenosine A3 receptor stimulation on seizures in mice. ( Carter, MF; Deutsch, SI; Jacobson, KA; Lin, RC; Mastropaolo, J; Meshulam, Y; Von Lubitz, DK, 1995) |
| "Ontogenetic differences in seizure thresholds to pentylenetetrazol (PTZ) were examined in young, developing rats (ages: 10, 18, 28, and 60 days)." | 1.29 | Ontogenetic development and pentylenetetrazol seizure thresholds in rats. ( Mostofsky, DI; Weller, A, 1995) |
| "PCP injection had little effect on the seizure susceptibility of older rats." | 1.29 | Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures. ( Moshe, SL; Sircar, R; Veliskova, J, 1994) |
| "Pentylenetetrazole-induced seizure thresholds were similar in mice treated for 14 days with lorazepam or alprazolam, 2 mg/kg/day." | 1.29 | Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam. ( Byrnes, JJ; Greenblatt, DJ; Miller, LG; Shader, RI, 1993) |
| "1." | 1.29 | Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil. ( Hönack, D; Löscher, W, 1994) |
| "Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor." | 1.29 | Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1993) |
| "When flumazenil or ZK 93426 was given to diazepam tolerant mice, this reversal was complete." | 1.29 | A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice. ( Kapetanovic, IM; Kupferberg, HJ; Torchin, CD, 1993) |
| "They also exhibited severe seizure discharge activity of prolonged duration at any given dose of either picrotoxin or pentylene tetrazole." | 1.29 | Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats. ( Bolster, B; Dakshinamurti, K; Sharma, SK, 1994) |
| " The compounds were tested against seizures induced by electroshock (MES) and pentylenetetrazol (scPTZ) in mice dosed intraperitoneally." | 1.29 | Anticonvulsant activity of some 4-amino-N-phenylphthalimides and N-(3-amino-2-methylphenyl)phthalimides. ( Bailleux, V; Nuyts, JP; Vallée, L; Vamecq, J, 1994) |
| "Rats treated with diazepam for 3 weeks were tolerant to diazepam, clonazepam, clobazam, and midazolam." | 1.29 | Comparison of anticonvulsant tolerance, crosstolerance, and benzodiazepine receptor binding following chronic treatment with diazepam or midazolam. ( Ramsey-Williams, VA; Rosenberg, HC; Wu, Y, 1994) |
| "A single seizure was induced by pentylenetetrazol (PTZ; 150 mg/kg i." | 1.29 | Persistent physiological effects caused by a single pentylenetetrazol induced seizure in neonatal rats. ( Boon, F; Cain, DP; Leung, LS; Zhao, D, 1994) |
| "An earlier pharmacodynamic study of the chiral antiepileptic drug stiripentol in an intravenous pentylenetetrazol-induced seizure model in the rat showed the development of a significant degree of tolerance to the anticonvulsant and neurotoxic effects following subacute treatment with the racemic compound." | 1.29 | Stereoselective pharmacokinetics of stiripentol: an explanation for the development of tolerance to anticonvulsant effect. ( Arends, RH; Baillie, TA; Levy, RH; Shen, DD; Zhang, K, 1994) |
| "There was no effect on seizure outcome, whereas the learning deficit was ameliorated in the kindled group." | 1.29 | Naloxone ameliorates the learning deficit induced by pentylenetetrazol kindling in rats. ( Becker, A; Brosz, M; Grecksch, G, 1994) |
| "Chronic seizures causes the decrease in tissue CA levels." | 1.29 | [Alimentary modification of catecholamine levels and status of the thiol-dependent protective system in the brain in convulsive syndrome]. ( Alekseeva, NR; Ikkert, OV; Sarbaev, BT; Sydykov, BU; Tazhibaev, ShS; Tishchenko, EG; Zhumasheva, LZh, 1993) |
| "Chemically provoked seizures have proved to serve as useful model to investigate long term neuronal responses collectively termed as neuronal plasticity." | 1.29 | Seizures-evoked activation of transcription factors. ( Kaczmarek, L; Kamińska, B; Lukasiuk, K, 1994) |
| "Other convulsion types, e." | 1.29 | Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice. ( Keith, LD; Roberts, AJ, 1994) |
| "During late seizures, this difference dropped to 2." | 1.29 | Membrane lipid degradation is related to interictal cortical activity in a series of seizures. ( Bazan, NG; Kreisman, NR; Rodriguez de Turco, EB; Visioli, F, 1994) |
| "In the case of the electrically induced seizures, we also compared the glial response in animals that had never experienced a seizure with the response in animals that previously had been kindled but had not experienced a seizure for 30 days." | 1.29 | Glial response to neuronal activity: GFAP-mRNA and protein levels are transiently increased in the hippocampus after seizures. ( Lothman, E; Steward, O; Torre, ER, 1993) |
| "Midazolam is a water-soluble benzodiazepine proven to be efficacious in sedation, hypnosis, and induction and maintenance of anesthesia." | 1.29 | Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine. ( Bradford, SM; Orebaugh, SL, 1994) |
| "2." | 1.29 | Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines. ( Chimirri, A; DeSarro, A; DeSarro, GB; Grasso, S; Zappalà, M, 1993) |
| "During early seizures, both FFA and diacylglycerols increased in the cerebral cortex, particularly arachidonate (20:4) and stearate (18:0)." | 1.29 | Free fatty acid and diacylglycerol accumulation in the rat brain during recurrent seizures is related to cortical oxygenation. ( Bazan, NG; Kreisman, NR; Rihn, LL; Rodriguez de Turco, EB; Visioli, F, 1993) |
| "By 24 h post seizure, baseline levels were detected." | 1.29 | Expression of the mas proto-oncogene in the rat hippocampal formation is regulated by neuronal activity. ( Hockfield, S; Martin, KA, 1993) |
| "A parenchymal brain granuloma is the final consequence of a localized inflammatory reaction against an infectious agent, particularly parasites." | 1.29 | Changes in the threshold of pentylenetetrazol-induced seizures in cats with a chronic granuloma in brain amygdala. ( Calvillo, M; Paz, C; Sotelo, J, 1993) |
| "The behavioral pattern of convulsion produced by pentylenetetrazol was similar to that produced by systemic administration of BW373U86." | 1.29 | Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice. ( Chang, KJ; Comer, SD; De Costa, BR; Hoenicke, EM; McNutt, RW; Mosberg, HI; Sable, AI; Woods, JH, 1993) |
| "glucocorticoids on convulsions." | 1.29 | Type I corticosteroid receptors modulate PTZ-induced convulsions of withdrawal seizure prone mice. ( Crabbe, JC; Keith, LD; Roberts, AJ, 1993) |
| " These observations indicated that 5-HT3 receptor antagonists are ineffective in attenuating hyperlocomotor activity following abrupt termination of chronic administration of ethanol or diazepam, and increased sensitivity to PTZ in the ethanol-withdrawn rats." | 1.29 | Ethanol- and diazepam-withdrawal hyperlocomotion is not due to 5-HT3 receptor stimulation. ( Mehta, AK; Ticku, MK, 1993) |
| "Acute epileptic seizures, induced by a convulsive dose of 50 mg/kg pentylenetetrazol (PTZ), strongly increased NGF mRNA in neurons of the granular layer of the dentate gyrus 3 hr but not 6 hr after the injection." | 1.29 | Pentylenetetrazol seizures increase pro-nerve growth factor-like immunoreactivity in the reticular thalamic nucleus and nerve growth factor mRNA in the dentate gyrus. ( Cao, Y; Ebendal, T; Humpel, C; Olson, L, 1993) |
| "On day 1 the clonic and tonic seizure latencies were increased from 160." | 1.29 | Chronic L-lysine develops anti-pentylenetetrazol tolerance and reduces synaptic GABAergic sensitivity. ( Cauley, RK; Chang, YF; Gao, XM; Wang, Y, 1993) |
| " The long-lasting decrease in seizure threshold following CIE treatment resembled the "kindling" phenomenon produced by chronic administration of PTZ (25 mg/kg, 3 times/week)." | 1.29 | The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol. ( Kokka, N; Olsen, RW; Sapp, DW; Taylor, AM, 1993) |
| "mice against convulsions induced by NMDLA and maximal electroshock but it had no significant effect on PTZ-induced convulsions." | 1.29 | Anticonvulsant effects of extracts of the west African black pepper, Piper guineense. ( Abila, B; Davies, JA; Richens, A, 1993) |
| "Nifedipine was found to have anticonvulsant activity in both models but flunarizine only had an anticonvulsant effect in the PTZ seizure incidence/latency test." | 1.29 | Protective effect of flunarizine and nifedipine alone and in combination with anticonvulsant drugs against PTZ-induced seizures in mice. ( Pleuvry, BJ; Rodger, C, 1993) |
| "After PTZ or flurothyl seizures, both ages exhibited similar patterns of IR in amygdala, pyriform cortex, and hypothalamus." | 1.29 | Differences in c-fos immunoreactivity due to age and mode of seizure induction. ( Firkusny, IR; Jensen, FE; Mower, GD, 1993) |
| "However, they do not affect clonic seizures with preserved righting reflexes." | 1.29 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester. ( Kusá, R; Mares, P; Roztocilová, L; Velísek, L, 1995) |
| "Convulsive seizure caused by kainate significantly induced the expression of activin beta A mRNA." | 1.29 | Increase in activin beta A mRNA in rat hippocampus during long-term potentiation. ( Hiraia, K; Hishinuma, F; Inokuchi, K; Inoue, M; Kato, A; Ozawa, F, 1996) |
| "Seizures were induced with i." | 1.29 | Glottal patency during experimental seizures in piglets. ( Kadison, A; Terndrup, TE; Woo, P, 1995) |
| "Occasional, mild seizures occur in NPY-deficient mice and mutants are more susceptible to seizures induced by a GABA (gamma-aminobutyric acid) antagonist." | 1.29 | Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. ( Clegg, KE; Erickson, JC; Palmiter, RD, 1996) |
| "To isolate seizure-related genes, we applied differential screening technique to the cDNA library which constructed from primary cultured cerebral cortical cells treated with pentylenetetrazol (PTZ)." | 1.29 | Molecular characterization of seizure-related genes isolated by differential screening. ( Kajiwara, K; Kimura, M; Nagawawa, H; Ookuri, T; Shimizu-Nishikawa, S; Sugaya, E, 1996) |
| "The effect of a single neonatal convulsion on subsequent behaviour was investigated in the male rat." | 1.29 | The effects of a single neonatally induced convulsion on spatial navigation, locomotor activity and convulsion susceptibility in the adult rat. ( Boon, F; Cain, DP; Kornelsen, RA; Leung, LS, 1996) |
| "Generalised or partial seizures are a common problem with many supratentorial gliomas." | 1.29 | The effects of malignant glioma on the EEG and seizure thresholds: an experimental study. ( Beaumont, A; Clarke, M; Whittle, IR, 1996) |
| "= 2." | 1.29 | D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. ( Bartsch, R; Engel, J; Hönack, D; Kutscher, B; Löscher, W; Polymeropoulos, EE; Rostock, A; Rundfeldt, C; Tober, C; White, HS; Wolf, HH, 1996) |
| "Increased susceptibility to seizures in the deficient animals was observed as increased severity of the seizures, decreased threshold for the dose of the chemostimulant and time to seizure, or a combination thereof." | 1.29 | Indispensable amino acid deficiency and increased seizure susceptibility in rats. ( Barrett, JA; Dixon, KD; Gietzen, DW; Jones, AC; Truong, BG; Washburn, DS, 1996) |
| "Zaleplon was more potent than zolpidem but the maximal effect of zolpidem for increasing the latency to isoniazid-induced convulsions was greater than that of zaleplon." | 1.29 | Comparison of the pharmacological profiles of the hypnotic drugs, zaleplon and zolpidem. ( Morel, E; Perrault, G; Sanger, DJ, 1996) |
| "Nitric oxide may be involved in seizure phenomena even though data often seem to be contradictory." | 1.29 | NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice. ( Borowicz, KK; Błaszczak, P; Czuczwar, SJ; Drelewska, E; Kleinrok, Z; Urbańska, EM, 1996) |
| "Furthermore, (+)MK-801 antagonized seizures induced by either lindane, PTX or PTZ with similar potencies in both mouse lines." | 1.28 | Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers. ( Serratosa, J; Trullas, R; Tusell, JM; Vendrell, M, 1992) |
| "When isbufylline-pretreated rats were challenged with pentylenetetrazole, the EEG was characterized by a short run of wave discharges (whose duration was shorter than that of other groups)." | 1.28 | Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study. ( Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S, 1992) |
| "Two types of motor seizures--minimal, clonic and major, generalized tonic-clonic--were elicited by a 100-mg/kg dose of metrazol (s." | 1.28 | Antimetrazol action of two potential anticonvulsants, CM 40907 and SR 41378, in immature rats. ( Mares, P; Stanková, L, 1992) |
| "Tonic-clonic seizures, matched for duration, were induced by MES applied by earclips (40 mA, 1 s) and intraperitoneal injections of PTZ (60 mg/kg); tonic hindlimb extension was present only after MES." | 1.28 | Regional expression of fos-like immunoreactivity following seizures induced by pentylenetetrazole and maximal electroshock. ( Coffey, P; Dean, P; Redgrave, P; Shehab, S, 1992) |
| "in the rat brain during and after seizure induced by PTZ were measured by using near-infrared spectrophotometry." | 1.28 | Cerebral oxygenation state in chemically-induced seizures in the rat--study by near infrared spectrophotometry. ( Hoshi, Y; Tamura, M, 1992) |
| "In posture change, the first signs of seizure appeared after age 6 weeks with maximal frequency at 8-9 weeks." | 1.28 | Intrinsic and drug-induced seizures of adult and developing gerbils. ( Ito, M; Kudo, T; Mizutani, A; Seto-Ohshima, A, 1992) |
| "This PTZ kindled seizure model appears to mimick generalized seizure and be useful in the investigation of seizure phenomenon." | 1.28 | Effects of injection interval on pentylenetetrazol (PTZ) kindled seizures in rats. ( Ono, J; Walson, PD, 1991) |
| "The preproenkephalin A gene is a neurotransmitter gene whose expression can be modulated "trans-synaptically" by changes in neuronal activity." | 1.28 | Preproenkephalin promoter "cassette" confers brain expression and synaptic regulation in transgenic mice. ( Brannock, MT; Donovan, DM; O'Hara, BF; Takemura, M; Uhl, GR, 1992) |
| "The number and intensity of generalized seizure reactions after injection of pentylenetetrazole were decreased." | 1.28 | [Increase of seizure threshold and resistance to stress in rats after immunization against fragment of diazepam-binding inhibitor]. ( Ashmarin, IP; Kalashnikov, VV; Maksimov, VV; Mizenko, GA; Rozhanets, VV; Samukov, VV; Vakulina, OP, 1992) |
| "At P14, LC was not affected by seizures." | 1.28 | An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. I. Behavioral characterization and determination of lumped constant. ( de Vasconcelos, AP; el Hamdi, G; Nehlig, A; Vert, P, 1992) |
| "Seizures were induced in dogs to further study the effect on central nervous system TRH in a species known to show epileptiform seizures." | 1.28 | Regional changes in central nervous system thyrotropin-releasing hormone after pentylenetetrazol-induced seizures in dogs. ( Durbin, S; Goodwin, S; Javed, T; Kubek, M; Sanders, S; Shapiro, S, 1992) |
| "In addition, ED and latency to convulsion were measured in WSP and WSR mice at 5 different concentrations of PTZ." | 1.28 | Neural sensitivity to pentylenetetrazol convulsions in inbred and selectively bred mice. ( Crabbe, JC; Cross, SJ; Kosobud, AE, 1992) |
| "Kindled seizures evoked by electrical stimulation of limbic pathways in the rat induce sprouting and synaptic reorganization of the mossy fiber pathway in the dentate gyrus (DG)." | 1.28 | Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization. ( Cavazos, JE; Golarai, G; Sutula, TP, 1992) |
| "Typical motor seizures accompanied by convulsions were evoked by intermittent light stimulation in F." | 1.28 | Pattern of electroencephalographic activity during light induced seizures in genetic epileptic chicken and brain chimeras. ( Batini, C; Guy, N; Le Douarin, N; Le Gal la Salle, G; Naquet, R; Schuler, B; Teillet, MA, 1992) |
| "Hence seizure-related changes in hippocampal prodynorphin neuron activity seem to depend on the experimental model of epilepsy." | 1.28 | The prodynorphin system in the rat hippocampus is differentially influenced by kainic acid and pentetrazole. ( Lasoń, W; Przewłocka, B; Przewłocki, R, 1992) |
| "Seizures were induced by PTZ in doses from 40 to 120 mg/kg s." | 1.28 | Pentylenetetrazol-induced seizures in rats: an ontogenetic study. ( Kubova, H; Mares, P; Pohl, M; Schickerova, R; Stankova, L; Velisek, L, 1992) |
| "The PTZ seizure threshold determined in various rabbit groups during the control phase of conducted experiments, was found to be in the range of 10." | 1.28 | The comparative effects of propofol, thiopental, and diazepam, administered intravenously, on pentylenetetrazol seizure threshold in the rabbit. ( al-Hader, A; Hasan, M; Hasan, Z, 1992) |
| "The effects of intratectal BMI were seizure model-dependent, suggesting different functional interconnections between tectum and those pathways responsible for generalization of MES as compared to PTZ or bicuculline convulsions." | 1.28 | Infusion of bicuculline methiodide into the tectum: model specificity of pro- and anticonvulsant actions. ( Rosenberg, HC; Weng, X, 1992) |
| "557 l/h/kg) and a shorter half-life (2." | 1.28 | Comparative anticonvulsant potency and pharmacokinetics of (+)-and (-)-enantiomers of stiripentol. ( Boddy, AV; Lepage, F; Levy, RH; Savitch, JL; Shen, DD; Tombret, F, 1992) |
| "The kindled-convulsion model was used to assess the development of tolerance and cross tolerance to the anticonvulsant effects of antiepileptic drugs." | 1.28 | Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine. ( Hudda, MM; Kim, CK; Pinel, JP; Wong, DJ; Yung, A, 1992) |
| "Ethyl acetate produced generalized clonic seizures and deaths at high doses and was ineffective to prevent electroshock- and PTZ-induced seizures at low doses." | 1.28 | Anticonvulsant and convulsant effects of organic solvents. ( Pires, ML; Shiotsuki, N; Silva-Filho, AR, 1992) |
| "Diazepam was antagonized by the benzodiazepine inverse agonists and by the neutral antagonist." | 1.28 | In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole. ( Ashton, D; Clincke, GH; Fransen, J; Heeres, J; Janssen, PA, 1992) |
| "Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain." | 1.28 | Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. ( Beal, MF; MacGarvey, U; Miller, J; Vécsei, L, 1992) |
| "motor seizures) as well as the development of kindling." | 1.28 | MK-801 prevents chemical kindling induced by pentylenetetrazol in rats. ( Corda, MG; Giorgi, O; Lecca, D; Orlandi, M, 1991) |
| "Flumazenil did not produce any significant pharmacological effect." | 1.28 | In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates. ( Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M, 1991) |
| "N-Ac-L-Phe-L-Glu was active against myoclonic seizures induced by GLU and NMDA under simultaneous i." | 1.28 | Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice. ( Garyaev, AP; Piotrovsky, LB; Poznyakova, LN, 1991) |
| "In fact, no convulsions were observed in the first week of treatment, but all the animals became sensitized to PTZ by the 12th week." | 1.28 | Decrease in the function of the gamma-aminobutyric acid-coupled chloride channel produced by the repeated administration of pentylenetetrazol to rats. ( Biggio, G; Corda, MG; Giorgi, O; Longoni, B; Orlandi, M, 1990) |
| "The concentrations of central neuropeptides, somatostatin (SS) and substance-P (SP), were determined in the different brain regions of young-aged male rats after a long-term administration of anticonvulsants Qingyangshen (QYS), Diphenylhydantoin (DPH), and Carbamazepine (CBZ)." | 1.28 | The investigation of antiepileptic action of qingyangshen (QYS)--effect of QYS on the concentrations of neuropeptides in rat brain. ( Kuang, P; Lang, S; Liu, J; Wu, W; Zhang, F, 1991) |
| "Intensity of convulsions was expressed in points." | 1.28 | [Corazol kindling in rats with different tolerance to hypoxia]. ( Agadzhanian, NA; Kryzhanovskiĭ, GN; Starykh, EV; Torshin, VI, 1991) |
| "The subsequent seizures were monitored and recorded on videotape and any subsequent mortalities were noted." | 1.28 | Inhibitory effects of powerline-frequency (60-Hz) magnetic fields on pentylenetetrazol-induced seizures and mortality in rats. ( Cain, DP; Ossenkopp, KP, 1991) |
| "Pretreatment with naloxone (10 mg/kg, SC, 30 min prior to testing), which did not affect the responsiveness of nonstressed mice to the hot plate or to the convulsant treatments, attenuated the development of analgesia following CRS, but not SS, and further prolonged the latency to onset of PTZ-induced convulsions in both stressed groups." | 1.28 | Effects of cold-restraint and swim stress on convulsions induced by pentylenetetrazol and electroshock: influence of naloxone pretreatment. ( De Lima, TC; Rae, GA, 1991) |
| "During early seizures, cortical CBF increased to 350% of control and cortical oxygenation also rose markedly." | 1.28 | Relative hypoperfusion in rat cerebral cortex during recurrent seizures. ( Brizzee, BL; Kreisman, NR; Magee, JC, 1991) |
| "The immunization lowered the seizure activity in single injections of threshold doses, (60 mg/kg) of pentylenetetrazole." | 1.28 | [The convulsive activity of white rats after immunization with a conjugate of sidnofen and serum albumin]. ( Ashmarin, IP; Danilova, RA; Kustova, EV; Obukhova, MF, 1991) |
| "The incidence of lidocaine-induced convulsions was decreased by treatments with alpha-MPT and disulfiram, while that of PTZ was increased by either treatment." | 1.28 | Changes in convulsion susceptibility of lidocaine by alteration of brain catecholaminergic functions. ( Dohi, T; Takada, K; Tanaka, S; Tsujimoto, A; Yoshimura, Y, 1991) |
| "PTZ not only induced seizures, but also inhibited specific [3H]FTZ binding to brain membranes in a dose-dependent manner." | 1.28 | Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by L-lysine. ( Chang, YF; Chen, JS; Gao, XM, 1991) |
| "Generalized convulsion appeared after intraperitoneal administration of 50 mg/kg PTZ with a latency of 68." | 1.28 | [Involvements of neuropeptides in pentylenetetrazol-induced convulsion in rats and effects of TRH and ceruletide on the convulsion]. ( Fujimoto, H; Hashiguchi, S; Kawai, H; Masuda, T; Saito, S, 1990) |
| "The seizures were interrupted at various stages of the syndrome (50 min to 24 h after injection of the toxin) by injecting thiopental (50 mg/kg i." | 1.28 | Effect of anticonvulsant treatment on kainic acid-induced increases in peptide levels. ( Marksteiner, J; Prommegger, R; Sperk, G, 1990) |
| "Convulsions were caused by intraabdominal injections of corazol." | 1.28 | [Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis]. ( Agadzhanian, NA; Starykh, EV; Torshin, VI, 1991) |
| "After daily repeated PTZ convulsions, a significant increase of A1 receptors by 26% appeared also in cortex, while the changes of A1 receptors observed in the other brain areas after a single PTZ convulsion were maintained in almost the same range." | 1.28 | Alterations of A1 adenosine receptors in different mouse brain areas after pentylentetrazol-induced seizures, but not in the epileptic mutant mouse 'tottering'. ( Angelatou, F; Kostopoulos, G; Pagonopoulou, O, 1990) |
| "The percentage of convulsions was greater in the kindled mice, compared to controls." | 1.28 | Threshold to elicit seizures by picrotoxin is lowered in pentylenetetrazol-kindled mice. ( Becker, A; Grecksch, G; Matthies, H, 1990) |
| "Major seizures were suppressed only in adult rats with a 20 mg/kg dose; on the other hand, ORG 6370 exhibited a selective action against the tonic phase of major seizures at all stages of development." | 1.28 | Influence of a new antiepileptic drug ORG 6370 on metrazol-induced seizures in rats during ontogenesis. ( Bĕlská, M; Mares, P; Mirvaldová, H, 1990) |
| "Major seizures were significantly suppressed with the highest dose of AP7 (60 mg/kg) in all groups except 7-day-old rats." | 1.28 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. ( Kulovaná, M; Kusá, R; Mares, P; Velísek, L, 1990) |
| "Chrysin was found to be a ligand for the benzodiazepine receptors, both central (Ki = 3 microM, competitive mechanism) and peripheral (Ki = 13 microM, mixed-type mechanism)." | 1.28 | Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. ( Calvo, D; Diaz, LE; Levi de Stein, M; Medina, JH; Paladini, AC; Peña, C; Wolfman, C, 1990) |
| "By using a rat seizure model, a comparison of the antiseizure activity of 12 dihydropyridine calcium channel antagonists (administered i." | 1.28 | The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat. ( Morón, MA; Stevens, CW; Yaksh, TL, 1990) |
| "However, the susceptibility to seizures induced by PTZ, which was measured by the mean number of generalized convulsions (GCs) as well as a mean duration of the 1st GC and severity score, was more enhanced in the rats exposed to perinatal hypoxia than in the control group at every age." | 1.28 | The effects of perinatal hypoxia on pentylenetetrazol-induced seizures in developing rats. ( Matsumoto, M, 1990) |
| "The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion." | 1.28 | Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures. ( Gonsalves, SF; Harbaugh, RE; Krogsgaard-Larsen, P; Schousboe, A; Twitchell, B, 1989) |
| "Pentylenetetrazol (PTZ)-induced convulsion were studied in control, chronic ethanol-maintained, and ethanol-withdrawal rats." | 1.28 | Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites. ( Mehta, AK; Ticku, MK, 1989) |
| " The pharmacokinetics of phenobarbital were studied in a separate set of rats (elimination half-life 11 +/- 2 hr)." | 1.28 | Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats. ( Danhof, M; Dingemanse, J; van Bree, JB, 1989) |
| "4." | 1.28 | Examination of the potential antiepileptic activity of calcium antagonists with different sites of action. ( Rahwan, RG; Wong, WS, 1989) |
| "In both seizure models Saffan induced anticonvulsant activity only at doses associated with neurological deficit." | 1.28 | Anticonvulsant profile of an anesthetic steroid. ( Peterson, SL, 1989) |
| "During the 30-min interval after seizure initiation, PGE2 secretion rates into the ventriculocisternal perfusate rose by five- to sevenfold." | 1.28 | CNS stimulation and PGE2 release. III. Pentamethylenetetrazole-induced seizures. ( Navarro, E; Romero, SD; Yaksh, TL, 1989) |
| "Seizures were induced in male, Swiss Webster mice with pentylenetetrazol (PTZ) or 3-mercaptoproprionic acid (3-MP)." | 1.27 | Anticonvulsant actions of fominoben: possible involvement of benzodiazepine receptors. ( Baldino, F; Geller, HM; Krespan, B, 1984) |
| "The treatment was found to prevent seizures induced by pentylenetetrazol." | 1.27 | Forskolin suppresses seizures induced by pentylenetetrazol in mice. ( Mizutani, A; Sano, M; Seto-Ohshima, A, 1984) |
| "Mice were kindled to produce minimal convulsions by repeated application of either electrical or chemical stimuli." | 1.27 | Interaction between delta-9-tetrahydrocannabinol and kindling by electrical and chemical stimuli in mice. ( Calder, LD; Karler, R; Sangdee, P; Turkanis, SA, 1984) |
| "Adenosine also appears to suppress seizure activity." | 1.27 | Regulatory effects of neurotransmitters on electroshock and pentylenetetrazol seizures. ( Burley, ES; Ferrendelli, JA, 1984) |
| "In audiogenic seizure mice, glial CA activity is increased and glial anion transport is reduced." | 1.27 | Ionic and acid-base regulation of neurons and glia during seizures. ( Chen, CF; Chow, SY; Engstrom, FL; Kemp, JW; White, HS; Woodbury, DM, 1984) |
| " for 14 days) the corresponding dose-response lines were shifted to the right suggesting tolerance development." | 1.27 | Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal. ( Gonzalez, JP; McCulloch, AJ; Nicholls, PJ; Sewell, RD; Tekle, A, 1984) |
| "Generalized tonic-clonic convulsions appeared with typical changes in the electroencephalogram 7-35 s after administration of the epileptogenic drugs." | 1.27 | Intracranial pressure during prolonged experimental convulsions in cats. ( Goitein, KJ; Shohami, E, 1983) |
| "Morphine dependence was induced in 90-day-old mice (weighing 29 to 32 g) by a 6-day schedule of twice daily i." | 1.27 | Effect of different convulsant drugs on some seizure parameters in morphine-dependent mice. ( Aleman, V; de Muñoz, DM, 1983) |
| "DMCM seizures were antagonized by benzodiazepine (BZ) receptor antagonists, such as Ro 15-1788, CGS 8216 and several beta-carboline-3-carboxylates, which all fail to inhibit pentylenetetrazol seizures." | 1.27 | DMCM: a potent convulsive benzodiazepine receptor ligand. ( Petersen, EN, 1983) |
| "Ro 15-1788 antagonised the tonic convulsions triggered by the drug combinations when it was given at the same time as Ro 5-4864; this antagonism was not observed when the drugs were injected at different times." | 1.27 | On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain. ( File, SE; Green, AR; Nutt, DJ; Vincent, ND, 1984) |
| "Ro 15-1788 suppressed generalized convulsive seizures induced by a minimal convulsive dose of pentylenetetrazol (25-35 mg/kg), but did not block the effects of higher doses (35-45 mg/kg)." | 1.27 | The partial benzodiazepine agonist properties of Ro 15-1788 in pentylenetetrazol-induced seizures in cats. ( Kaijima, M; Le Gal La Salle, G; Rossier, J, 1983) |
| "In chemically elicited seizures in mice, CM 40142 exhibited a higher potency than sodium valproate in antagonizing anti-GABAergic agents." | 1.27 | Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons). ( Bizière, K; Calassi, R; Chambon, JP; Leyris, R; Maruani, J; Molimard, JC; Rodier, D; Roncucci, R; Sigault, G, 1984) |
| "These results suggest that sustained convulsions induce overall excitation of the central nervous system and result in the enhancement of LH release from the pituitary." | 1.27 | Differential effects of picrotoxin- and pentylenetetrazol-induced convulsions on the secretion of luteinizing hormone and follicle-stimulating hormone in rats. ( Fujii, T; Ikeda, H; Nonaka, C, 1984) |
| "In the maximal electroshock seizure test, the median effective dose (ED50) is 457 mg/kg and the protective index (PI) is 3." | 1.27 | Anticonvulsant activity and neurotoxicity of piperonyl butoxide in mice. ( Ater, SB; Franklin, MR; Swinyard, EA; Tolman, KG, 1984) |
| "Diazepam treatment during the course of kindling significantly increased the number of stimulation trials required to produce stage 5 motor seizures but did not inhibit the fall in CaBP." | 1.27 | Hippocampal calcium-binding protein during commissural kindling-induced epileptogenesis: progressive decline and effects of anticonvulsants. ( Baimbridge, KG; Miller, JJ, 1984) |
| "The results indicated that seizure proneness, whether induced by a history of prior convulsions or brain damage, increased sensitivity to morphine." | 1.27 | Morphine responsiveness and seizure proneness. ( Mansour, A; Valenstein, ES, 1984) |
| "Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior." | 1.27 | Metabolic and behavioral consequences of lidocaine-kindled seizures. ( Ingvar, DH; Kennedy, C; Miyaoka, M; Post, RM; Shinohara, M; Sokoloff, L; Squillace, K; Suda, S, 1984) |
| "The effects of seizures on the cerebral and peripheral metabolism of essential metals were studied in mice." | 1.27 | Generalized seizures alter the cerebral and peripheral metabolism of essential metals in mice. ( Miller, ST; Papavasiliou, PS, 1983) |
| "Repetitive stimulation and spontaneous seizures resulted in delta [Ca2+]o of up to 0." | 1.27 | Changes in [Ca2+]o and [K+]o during repetitive electrical stimulation and during pentetrazol induced seizure activity in the sensorimotor cortex of cats. ( Heinemann, U; Louvel, J, 1983) |
| " Male EC and IC rats did not differ in the CD50 (50% convulsion dosage by log probit analysis) following injection of a range of metrazol doses (20 to 35 mg/kg, IP) when they were kept in a quiet dimly lighted room." | 1.27 | Differential rearing affects responsiveness of rats to depressant and convulsant drugs. ( Conlee, JW; Greenough, WT; Juraska, JM, 1983) |
| "Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s." | 1.27 | Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats. ( Mares, P; Velísek, L, 1983) |
| "Milacemide has a low toxicity (LD50: 2585 mg/kg in the mouse) and alters the behaviour of mouse, rat and monkey, only at high doses (greater than or equal to 1000 mg/kg)." | 1.27 | Anticonvulsant activity of milacemide. ( Barris, D; Cordi, A; Roba, J; van Dorsser, W, 1983) |
| "The persistence of seizure susceptibility into adulthood following kindling in the immature rat was assessed." | 1.27 | Increased susceptibility to pentylenetetrazol-induced seizures in adult rats following electrical kindling during brain development. ( Holmes, GL; Weber, DA, 1983) |
| "Diazepam (4 mg/kg) was completely effective in blocking GDSC 2 hr post administration." | 1.27 | Inhibition of pentylenetetrazol induced genetically-determined stereotypic convulsions in tottering mutant mice by diazepam. ( Syapin, PJ, 1983) |
| "In the maximal pentetrazol seizures test in rats denzimol showed a profile similar to that of phenytoin and carbamazepine, but different from that of barbiturates and benzodiazepines so that it is suggested that its clinical application would be that of "grand mal" and psychomotor type seizures therapy." | 1.27 | Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile. ( Barbadoro, E; Graziani, G; Testa, R; Tirone, F, 1983) |
| "The onset of seizures was accompanied by a small perturbation of cerebral cortical energy state, but sustained changes were confined to decreases in phosphocreatine, glycogen, and glucose and increases in lactate, pyruvate, and cyclic nucleotides." | 1.27 | Metabolic, circulatory, and structural alterations in the rat brain induced by sustained pentylenetetrazole seizures. ( Folbergrová, J; Ingvar, M; Kalimo, H; Olsson, Y; Siesjö, BK; Söderfeldt, B, 1984) |
| "Myoclonic jerks were elicited by PTZ in all age groups studied." | 1.27 | Correlation between electrocorticographic and motor phenomena induced by pentamethylenetetrazol during ontogenesis in rats. ( Mares, P; Schickerová, R; Trojan, S, 1984) |
| "These convulsions are tonic-clonic." | 1.27 | Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds. ( Colombo, R; Ossi, C; Pinelli, A; Spazzi, L; Tofanetti, O, 1984) |
| "Diazepam completely inhibited the convulsions, but it has an undesirable strong myorelaxing effect." | 1.27 | Comparative study of the anticonvulsive activity of N-aminomethylpiperazine-3,3-diethyl 2,4-pyridinedione with the activity of known antiepileptic agents. ( Alov, P; Belcheva, I; Stoytchev, T, 1984) |
| "A progressive development of seizure activity after this treatment was observed." | 1.27 | Development and persistence of kindled seizures after repeated injections of pentylenetetrazol in rats and guinea pigs. ( Diehl, RG; Gotwo, T; Smialowski, A, 1984) |
| "Sound-induced seizures are suppressed by the i." | 1.27 | Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration. ( Croucher, MJ; Krogsgaard-Larsen, P; Meldrum, BS, 1983) |
| "During seizures, induced by the centrally acting convulsant pentylenetetrazol, cerebral concentrations of both prostaglandins were markedly enhanced as compared to basal conditions." | 1.27 | Increase in brain prostaglandins during convulsions is due to increased neuronal activity and not to hypoxia. ( Förstermann, U; Heldt, R; Hertting, G, 1983) |
| "During tonic convulsions, the amplitude of the DOPAC oxidation peak significantly decreased to 75% of the peak height recorded prior to the injection of PTZ, and the minimum lasted for about 30 min; then the mean curve slowly recovered to the control level within 60 min." | 1.27 | Determination of neurotransmitter release into the caudate nucleus during convulsions induced by pentylenetetrazole using in vivo differential pulse voltammetry. ( Fujikawa, N; Mori, A; Shirasu, A; Yamamoto, M; Yokoi, I, 1986) |
| "Here we report that generalized tonic-clonic seizures in mice are associated with a massive increase in c-fos protein-like immunoreactivity in the cingulate and piriform cortices and the dentate gyrus 1 h after injection of pentylenetetrazol." | 1.27 | Generalized seizures induce c-fos protein(s) in mammalian neurons. ( Dragunow, M; Robertson, HA, 1987) |
| "gamma-HCH was a potent seizure-inducing agent in mice while the alpha or the delta isomer significantly decreased mouse motor activity." | 1.27 | CNS biochemical and pharmacological effects of the isomers of hexachlorocyclohexane (lindane) in the mouse. ( Fishman, BE; Gianutsos, G, 1988) |
| "In contrast, the severity of seizures produced by N-methyl-dl-aspartate (NMA) was increased by nitrendipine." | 1.27 | Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine. ( Dolin, SJ; Halsey, MJ; Hunter, AB; Little, HJ, 1988) |
| "For each strain, when equivalent seizure thresholds were observed at different time points, equivalent receptor occupancies were also observed." | 1.27 | Evidence of strain differences in GABA-benzodiazepine coupling. ( File, SE; Martin, IL; Wilks, L, 1987) |
| "Pulmonary edema was always accompanied by prolonged increases in blood pressure and paroxysmal electrocortical activity, and by hypoxemia, acidemia, and decreased cerebral oxygen supply." | 1.27 | Role of pulmonary edema in phasic changes of cerebral oxygenation during serial seizures. ( Hodin, RA; Kreisman, NR; Rosenthal, M; Sick, TJ, 1987) |
| "On the other hand, the body seizures produced by PTZ were unaffected by any of the three opiate receptor antagonists that were given before the convulsant." | 1.27 | The impairment of retention induced by pentylenetetrazol in mice may be mediated by a release of opioid peptides in the brain. ( Baratti, CM, 1987) |
| "Seizures were produced by bicuculline or pentylenetetrazole." | 1.27 | Activation of a cranial vasodilator pathway during seizures in rats. ( Faraci, FM; Heistad, DD; Motley, MG, 1986) |
| "The analgesic treatments lowered the seizure threshold considerably in 5 out of 6 dogs, and fentanyl and pentazocine led to an increased incidence of clonic-tonic seizures after the end of the pentetrazole infusion." | 1.27 | Morphine-like analgesics and convulsive threshold for pentetrazole in dogs. ( Czuczwar, SJ; Frey, HH; Scherkl, R, 1986) |
| "Thereafter seizures were induced by pentylenetetrazol (PTZ)." | 1.27 | Effect of pentylenetetrazol-induced convulsions on somatostatin-like immunoreactivity in rat cerebrospinal fluid. ( Honkanen, KL; Jolkkonen, J; Pitkänen, A; Riekkinen, P, 1987) |
| "The dose response curve for strychnine seizure was shifted 2." | 1.27 | Effect of inferior olive lesion on seizure threshold in the rat. ( Anderson, MC; Chung, EY; Van Woert, MH, 1987) |
| "CGS 19755 inhibited convulsions elicited by maximal electroshock in rat (ED50 = 3." | 1.27 | CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. ( Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M, 1988) |
| "Both anti-5HT agents shortened convulsion latency in non-stressed animals." | 1.27 | Participation of serotonergic mechanisms in the anticonvulsant effect of stress in mice treated with pentylenetetrazol. ( De-Lima, TC; Rae, GA, 1988) |
| "Similar action on minimal metrazol seizures (mMS) was present in rats aged 18 days and more." | 1.27 | Anti-metrazol action of R 57720 during postnatal development in rats. ( Lanstiaková, M; Mares, P; Pohl, M, 1988) |
| "Pentylenetetrazole and picrotoxin seizure thresholds, measured during constant rate iv infusion, were significantly lowered by pretreatment with diazepam (250 mg/kg) and Ro 15-1788 (20 mg/kg) administered 30 and 20 minutes, respectively, before seizure threshold measurement." | 1.27 | Convulsant component of a depressant benzodiazepine. ( Bourn, WM; Garrett, RL, 1985) |
| "The acute administration of an anticonvulsant dose of ethosuximide (150 mg/kg) had no effect on brain gamma-aminobutyric acid (GABA) concentration, whereas a toxic dose (400 mg/kg) increased significantly the concentration of brain GABA (1." | 1.27 | Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice. ( Chweh, AY; Lin-Michell, E; Swinyard, EA, 1986) |
| "While Metrazole still elicited seizures during this period, reinduction of c-fos was largely refractory." | 1.27 | Mapping patterns of c-fos expression in the central nervous system after seizure. ( Cohen, DR; Curran, T; Hempstead, JL; Morgan, JI, 1987) |
| "By contrast, pentylenetetrazol seizures' characteristics were significantly changed in response to the intraperitoneal administration of the norepinephrine antagonist, 6-hydroxydopamine, by abolishing the tonic and clonic phases of the seizure." | 1.27 | Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice. ( Abed, WT, 1986) |
| "Generalized seizures evoked by injection of pentylenetetrazol produced a massive induction of fos protein(s) in the piriform and cingulate cortices as well as the dentate gyrus of rats." | 1.27 | Localization and induction of c-fos protein-like immunoreactive material in the nuclei of adult mammalian neurons. ( Dragunow, M; Robertson, HA, 1988) |
| "Meclofenoxate treatment for 5 days had an even more pronounced inhibitory effect on PTZ kindling." | 1.27 | Effect of meclofenoxate on pentylenetetrazol kindling in albino rats. ( Genkova, M; Georgiev, V; Lazarova, M; Markovska, V; Petkov, VD, 1987) |
| "The threshold of the generalized clonic convulsions induced by intravenous infusion of pentylenetetrazol (PTZ) was significantly increased by the intraperitoneal administration of noradrenaline (NA) neurotoxin, 6-hydroxydopamine, which produced no changes in the levels of catecholamines in discrete areas of rat brain, but the effect was accompanied by spinal depletion of NA." | 1.27 | A possible role for spinal noradrenaline in the mechanisms of 6-hydroxydopamine against pentylenetetrazol induced convulsions in rats. ( Abed, WT, 1988) |
| " Purely additive interactions were found for the anticonvulsant effect when valproate was combined with carbamazepine as well as with phenobarbital." | 1.27 | Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital. ( Bourgeois, BF, 1988) |
| "Withdrawal seizure prone (WSP) and withdrawal seizure resistant (WSR) lines of mice have been genetically selected based on the severity of handling-induced convulsions after identical chronic ethanol exposure." | 1.27 | Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice. ( Crabbe, JC; Feller, DJ; Harris, RA, 1988) |
| "Sixty seconds after the onset of seizure activity, the animals either received no drug (control) or propranolol (IV or IO via an 18-gauge spinal needle placed in the right proximal tibia)." | 1.27 | Suppression of pentylenetetrazol-elicited seizure activity by intraosseous propranolol in pigs. ( Dolce, K; Jim, KF; Kahn, C; Lathers, CM; Matthews, WD; Spivey, WH, 1988) |
| " Dose-response and time course studies of Ro 15-4513 against gamma-aminobutyric acid (GABA) antagonists were performed." | 1.27 | Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants. ( Lister, RG; Nutt, DJ, 1988) |
| "The convulsive-seizure-increasing effect of AT II was enhanced after multiple administration of pimozide and particularly after its withdrawal for 21 days." | 1.27 | Adaptive changes in the effects of angiotensin II on the convulsive-seizure threshold in cases of altered sensitivity of dopamine receptors. ( Georgiev, V; Kambourova, T; Petkova, B, 1988) |
| "These levels normalized 2 h after the convulsion." | 1.27 | Measurement during convulsions of guanidino compound levels in cerebrospinal fluid collected with a catheter inserted into the cisterna magna of rabbits. ( Edamatsu, R; Fujikawa, N; Hiramatsu, M; Mori, A; Shirasu, A; Suzuki, S; Yamamoto, M, 1988) |
| " No marked differences in pharmacodynamic parameters between the three time groups were found, which indicates that serum and brain are pharmacokinetically indistinguishable from the effect compartment, that there is no (inter)activity of oxazepam metabolites and absence of development of acute tolerance during the investigated time frame." | 1.27 | Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure. ( Breimer, DD; Danhof, M; Dingemanse, J; Sollie, FA, 1988) |
| "PTZ seizures were prevented by GVG injections in the anterior thalamus, the caudal hypothalamus, the superior colliculus, cerebellar nuclei, and in a large area of the medial medullary, pontine, and mesencephalic tegmentum encompassing the vestibular nuclei, the reticular formation, and portions of the central gray." | 1.27 | Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brainstem. ( Ferrendelli, JA; McKeon, AC; Miller, JW, 1987) |
| "The corn diet facilitated seizures; the low-protein/high-carbohydrate/tryptophan diet prevented seizures." | 1.27 | Does dietary tryptophan play a role in the control of convulsive activity? ( Alécio-de-Oliveira, EJ; Barreira, AM; Cabral-Filho, JE; Castro, RM; Teodósio, NR, 1987) |
| "During convulsion induced by pentylenetetrazole, enormous amounts of prostaglandin D2 (ca." | 1.27 | Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues. ( Hayaishi, O; Hayashi, H; Ito, S; Kawabe, H; Negishi, M; Tanaka, T; Watanabe, K; Yokohama, H, 1987) |
| "Male Long-Evans rats experienced three convulsions induced by intravenously administered pentylenetetrazol (PTZ) and were then kindled by electrical stimulation of the olfactory bulb or amygdala." | 1.27 | Effect of pentylenetetrazol-induced convulsions on the development and expression of limbic kindled seizures. ( Gramlich, CA; Stripling, JS, 1987) |
| "Similar seizure susceptibility patterns and activity differences have also been reported for the Long-Sleep and Short-Sleep selectively-bred mouse lines." | 1.27 | Differential convulsive susceptibility of high-activity and low-activity selected mice in response to GABA antagonists. ( Alpern, HP; McIntyre, TD, 1987) |
| "The diazepam preparations were administered intravenously to male mice." | 1.27 | The anticonvulsive activity and toxicity of diazepam in three different formulations. An experimental study in mice. ( Angelo, H; Bredgaard Sørensen, M; Carl, P; Høgskilde, S; Nielsen, JW, 1987) |
| " kindled rats show in the fully kindled state a marked shift of the dose-response curve for PTZ-seizures to the left." | 1.27 | Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol. ( Schmidt, J, 1987) |
| "The thresholds for inducing the maximal seizure by pentylenetetrazole (PTZ) were compared for BDF1 mice of both sexes with varying ages after intraperitoneal administration of various doses of PTZ." | 1.27 | Age-dependent increase in the threshold for pentylenetetrazole induced maximal seizure in mice. ( Kanai, S; Kitani, K; Masuda, Y; Nokubo, M; Ohta, M; Sato, Y, 1986) |
| "Verapamil significantly decreased seizure incidence and both it and flunarizine lowered mortality." | 1.27 | Calcium channel antagonists decrease the ethanol withdrawal syndrome. ( Dolin, SJ; Halsey, MJ; Little, HJ, 1986) |
| "Diazepam (0." | 1.27 | Intraosseous diazepam suppression of pentylenetetrazol-induced epileptogenic activity in pigs. ( Lathers, CM; McNamara, RM; Spivey, WH; Unger, HD, 1987) |
| "Both types of seizures were prevented by injections into both of the above brain regions." | 1.27 | Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures. ( Ferrendelli, JA; McKeon, AC; Mirski, MA, 1986) |
| " The PTZ infusion model was tested in a preliminary dose-response study of the anticonvulsant valproic acid (VPA)." | 1.27 | A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. ( Pollack, GM; Shen, DD, 1985) |
| "(iv) Generalized seizures induced by cortical perfusions showed a clear predominance of contractions in the muscles contralateral to the perfusion site, whereas perfusions in the MRF induced generalized seizures indistinguishable from those produced by i." | 1.27 | Comparative effects of topical perfusions of pentylenetetrazol in the mesencephalon and cerebral cortex of cats. ( Márquez, I; Pacheco, T; Velasco, F; Velasco, M, 1985) |
| "The s." | 1.27 | Antiepileptic drugs: detection, quantification, and evaluation. ( Kupferberg, HJ; Swinyard, EA, 1985) |
| "Three flurothyl convulsions decreased the afterdischarge threshold of the amygdala and enhanced the rate of development of electrical kindling without affecting the intensity of postictal refractoriness." | 1.27 | Unidirectional interaction between flurothyl seizures and amygdala kindling. ( Albala, BJ; Moshé, SL; Okada, R; Ono, K, 1985) |
| "Convulsions were induced in young rats (1-21 days) with pentylenetetrazol or hyperthermia." | 1.27 | A single neonatal pentylenetetrazol or hyperthermia convulsion increases kindling susceptibility in the adult rat. ( Cain, DP; Gilbert, ME, 1985) |
| "The effect of drug-induced convulsions on subsequent cortical kindling was studied in male Long-Evans rats." | 1.27 | Effect of cocaine and pentylenetetrazol on cortical kindling. ( Russell, RD; Stripling, JS, 1985) |
| "At higher doses, however, convulsions again emerged." | 1.26 | Central excitatory actions of flurazepam. ( Rosenberg, HC, 1980) |
| "The rise in seizure threshold still occurred when animals were pretreated with alpha-methyl-p-tyrosine (200 mg ." | 1.26 | Studies on the post-ictal rise in seizure threshold. ( Cowen, PJ; Green, AR; Nutt, DJ, 1981) |
| "Mice treated with tryptophol plus ethanol became highly susceptible to convulsion." | 1.26 | Changes in seizure susceptibility after successive treatments of mice with tryptophol and ethanol. ( Fukumori, R; Kitagawa, H; Minegishi, A; Satoh, T, 1981) |
| "Results suggest that (i) PTZ-induced seizures start in the brain stem reticular formation and propagate to muscles by at least two different pathways: a pyramidal and an extrapyramidal pathway; (ii) that inhibition of seizure activity may start at the cortical level." | 1.26 | Specific and non-specific multiple unit activities during pentylenetetrazol seizures. I. Animals with 'encéphale isolé'. ( Romo, R; Velasco, F; Velasco, M, 1980) |
| "It also suggests that termination of seizures is due to inhibitory influences of supramesencephalic structures." | 1.26 | Specific and non-specific multiple unit activities during pentylenetetrazol seizures in animals with mesencephalic transections. ( Romo, R; Velasco, F; Velasco, M, 1982) |
| "The pattern of maximal electroshock seizure was not affected by LC lesion, although the recovery time was slightly prolonged." | 1.26 | The role of the locus coeruleus in regulation of seizure susceptibility in rats. ( Oishi, R; Suenaga, N, 1982) |
| "They also increased the seizure threshold doses of intravenously infused pentetrazol and picrotoxin." | 1.26 | Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam. ( Zetler, G, 1980) |
| "Initial seizures evoked by pentylenetetrazol were accompanied by transient increases in tissue pO2 and cytochrome a,a3 oxidation, confirming that oxygen provision is adequate to meet metabolic demand." | 1.26 | Oxidative metabolic responses with recurrent seizures in rat cerebral cortex: role of systemic factors. ( Kreisman, NR; Lamanna, JC; Rosenthal, M; Sick, TJ, 1981) |
| "The binding of [3H] diazepam and [3H] flunitrazepam in rat cerebral cortex was not altered by either acute or chronic administration of pentylenetetrazol except in rats made to convulse 30 min before sacrifice." | 1.26 | Effect of acute and chronic pentylenetetrazol treatment on benzodiazepine and cholinergic receptor binding in rat brain. ( Lal, H; Lippa, AS; Mann, PA; Shearman, GT, 1981) |
| "Following these treatments, seizure thresholds to these drugs were measured by an IV infusion method to minimise problems of systemic uptake and metabolism of the drugs." | 1.26 | Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling). ( Batts, CC; Cowen, PJ; Grahame-Smith, DG; Green, AR; Nutt, DJ, 1982) |
| "In the case of picrotoxin induced convulsive seizures where there is an alteration at the GABA receptor level, ther is a lack of efficiency after nDPA treatment which increases GABA at the synaptic level." | 1.26 | [Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin]. ( Ciesielski, L; Mandel, P; Simler, S, 1981) |
| "c." | 1.26 | [Effect of anticonvulsants on convulsions induced by kynurenine, quinolinic acid, strychnine and corazole]. ( Lapin, IP; Ryzhov, IV, 1981) |
| "Methionine thus promotes convulsions under certain conditions, plerhaps due to an accumulation of homocysteine or of other metabolites with convulsive properties." | 1.26 | Production of convulsions in mice by the combination of methionine and homocysteine. ( Freed, WJ; Gillin, JC; Luchins, DJ; Taylor, SP; Wyatt, RJ, 1980) |
| "The sensitivity to insulin hypoglycemic convulsions has been shown to decrease at early times (16 and 24 hr) and increase at later times (1 week) after gold thioglucose (GTG) treatment." | 1.26 | Change in sensitivity to insulin hypoglycemic convulsions after gold thioglucose treatment: time course of development. ( Fish, KW; Holliday, JF; Luby, JL; Marrazzi, MA, 1981) |
| "Seizures were induced in female Wistar rats by electroconvulsive shock (ECS) or administration of pentetrazole (PTZ)." | 1.26 | Regional distribution of arachidonic acid metabolites in rat brain following convulsive stimuli. ( Anhut, H; Berchtold-Kanz, E; Heldt, R; Hertting, G; Neufang, B, 1981) |
| "A residual effect of DPA against seizures induced by pentetrazole was shown, i." | 1.26 | Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment. ( Ciesielski, L; Klein, M; Mandel, P; Simler, S, 1982) |
| "In the maximal seizure tests, tonic hindlimb extension was always abolished at plasma valproic acid concentrations of 225 microgram ml-1 and above." | 1.26 | The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat. ( Howe, GM; Howe, SJ; Tulloch, IF; Walter, DS, 1982) |
| " The effect of disulfiram was augmented by combination with tryptophan plus lithium, although neither tryptophan or lithium prolonged the latency to clonic seizure." | 1.26 | Effect of disulfiram in combination with L-tryptophan and lithium on pentylenetetrazol-induced seizure. ( Fukumori, R; Kitagawa, H; Minegishi, A; Satoh, T, 1982) |
| "The potentiation of picrotoxin convulsions was correlated with the pattern of kindling development but not with the number of stimulations or seizures." | 1.26 | Pharmacological investigation of convulsant gamma-aminobutyric acid (GABA) antagonists in amygdala-kindled rats. ( Kalichman, MW, 1982) |
| " Four anticonvulsant drugs, phenobarbital, phenytoin, trimethadione, and ethosuximide, were tested against brainstem-triggered convulsions in the rat using a standard pharmacological dose-response paradigm." | 1.26 | The effect of anticonvulsant drugs on convulsions triggered by direct stimulation of the brainstem. ( Burnham, WM; Chiu, P, 1982) |
| "In this study the pentetrazole seizure threshold of dogs was compared with the concentration of GABA in the CSF and blood plasma." | 1.26 | Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability. ( Löscher, W, 1982) |
| "Only slight decreases in seizure responsiveness were observed with strychnine induced seizures at either 1 or 14 h." | 1.26 | Effect of trimethyltin on chemically-induced seizures. ( Costa, LG; Doctor, SV; Murphy, SD, 1982) |
| "Ketamine has been evaluated for convulsant properties in animals and humans with contradictory results." | 1.26 | Ketamine suppression of chemically induced convulsions in the two-day-old white leghorn cockerel. ( Reder, BS; Trapp, LD; Troutman, KC, 1980) |
| " In the pups of all dosed groups, the convulsive threshold for PTZ is reduced significantly compared with that in the naive group." | 1.26 | Alteration of convulsive threshold and sensitivity to CNS acting drugs in sedative-hypnotics-experienced rat offspring. ( Hiramori, T; Nakao, K; Tagashira, E; Urano, T; Yanaura, S, 1982) |
| "chemically or electrically induced seizures, anticonvulsant drugs tested can be classified into four main groups; 1) drugs (trimethadione, ethosuximide, nitrazepam, diazepam, erthotoin and metharbital) with an effect to antagonize all the whole seizure components." | 1.26 | Differential antagonisms of anticonvulsants to various components of maximal seizures induced by electroshock or pentylenetetrazol in mice. ( Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Yoshida, K, 1980) |
| "At the same time, during tonic convulsions lasting longer than 50 sec, no more increase in the PGF2 alpha content of the brain was observed." | 1.26 | Studies on prostaglandin F2 alpha formation caused by pentametylenetetrazol-induced convulsions in rat brain. ( Antal, M; Folly, G; Schaefer, A; Seregi, A; Serfözö, P, 1981) |
| "In 4- and 5-day-old rats, generalized seizures were manifested as slow waves only." | 1.26 | Electrocorticographic activity elicited by metrazol during ontogenesis in rats. ( Brozek, G; Mares, P; Zouhar, A, 1980) |
| "kg-1 elicited genuine minimal seizures (predominantly clonic) in adult, 45- and 25-day-old rats." | 1.26 | Seizures elicited by subcutaneous injection of metrazol during ontogenesis in rats. ( Mares, P; Schickerová, R, 1980) |
| "During pentylenetetrazol-induced generalized seizures, intestinal activity was blocked, as demonstrated by the disappearance of spikes from the EMG." | 1.26 | Effects of PTZ-induced generalized epilepsy on intestinal activity in cats. ( Cherubini, E; Gonella, J; Mancia, D; Mecarelli, O; Tassinari, CA, 1981) |
| "Cardiazol induced seizures in rabbits showed that the highest oxypurine concentrations can be detected in the CSF 1 hour after the convulsions." | 1.26 | Increased nucleotide catabolism after cerebral convulsions. ( Dörner, K; Manzke, H; Staemmler, W, 1981) |
| "Susceptibility to audiogenic seizures returned upon cessation of sound." | 1.26 | Post-ictal resistance to audiogenic seizures in inbred mice. ( Alexander, GJ; Kopeloff, LM, 1980) |
| "Like haloperidol-pretreated rats they were able to maintain uncomfortable postures on the vertical grid or horizontal bar; although signs of rigidity were noticed, the rats would fail to remain self-supporting when placed across metal bookends ("bridge" test)." | 1.26 | Pharmacologic analysis of the postictal immobility syndrome in the rat. ( Kofman, O; Mintz, M; Myslobodsky, MS, 1981) |
| "The effect of drug-induced convulsions on kindling was studied in male Long-Evans rats." | 1.26 | Facilitation of kindling by convulsions induced by cocaine or lidocaine but not pentylenetetrazol. ( Hendricks, C; Stripling, JS, 1981) |
| "However, kindled convulsions do increase the PTZ-induced convulsion duration and severity relative to that seen in stimulated or unstimulated animals." | 1.26 | Effects of kindling or brain stimulation on pentylenetetrazol-induced convulsion susceptibility. ( Cain, DP, 1980) |
| "In contrast to results obtained when seizures are due to other causes, these results suggest that brain glucose transport is decreased during a seizure if the microvasculature has been previously subjected to ischemia." | 1.26 | Cerebral microvessel 2-deoxy-D-glucose uptake during ischemia-induced seizures. ( Nell, JH; Welch, KM, 1980) |
| "The relationship of the PTZ-induced seizure sequence of myoclonus, clonus and hindlimb extension (TE) to brain PTZ levels has not been reported." | 1.26 | Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice. ( Kupferberg, HJ; Woodbury, DM; Yonekawa, WD, 1980) |
| "For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s." | 1.26 | Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse. ( Blake, GJ; Gilbert, MB; Raines, A; Richardson, B, 1979) |
| "Effects of different types of epileptic seizure on the sleep organization of baboon were studied through 12 h polygraphic recordings." | 1.26 | Epilepsy and sleep organization in the baboon Papio papio. ( Naquet, R; Tanaka, T, 1976) |
| "Seizures were induced by repeated intravenous injections of pentylenetetrazol (PTZ, 10-20 mg/kg) or by local application of 1 M Na-penicillin." | 1.26 | Coupling between neuronal activity and focal blood flow in experimental seizures. ( Heiss, WD; Rappelsberger, P; Turnheim, M; Vollmer, R, 1979) |
| "India showed no abnormal seizure susceptibility or EEG response to photic stimulation and no electro-clinical features of epilepsy after pentylenetetrazol, 40 mg/kg sc." | 1.26 | Photic and pentylenetetrazol-induced seizure susceptibility in Macaca mulatta. ( David, J; Grewal, RS, 1977) |
| "Experiments with pentylenetetrazol convulsion model in albino mice--80 mg/kg subcutaneously--have revealed the following." | 1.26 | On some relationships between dopaminergic and serotoninergic mechanisms in pentylenetetrazol convulsions in albino mice. ( Lazarova, M; Roussinov, K, 1979) |
| " After acute and chronic administration of (+)-amphetamine (2." | 1.26 | The effects of chronic administration and withdrawal of (+)-amphetamine on seizure threshold and endogenous catecholamine concentrations and their rates of biosynthesis in mice. ( Gerald, MC; Riffee, WH, 1977) |
| "The thresholds of twitch and clonic convulsion induced by intravenous infusion of pentylenetetrazol (PTZ) were measured in rats treated with 6-hydroxydopamine (6-OHDA)." | 1.26 | Possible involvement of brainstem norepinephrine in pentylenetetrazol convulsions in rats. ( Fukuda, T; Oishi, R; Suenaga, N, 1979) |
| "A significant potentiation of the seizures induced both by Metrazol and by electroconvulsive shock was found in animals depleted of brain noradrenaline, but no alteration was seen after depletion of brain dopamine on either measure." | 1.26 | Catecholamines and convulsions. ( Corcoran, ME; Mason, ST, 1979) |
| "They did not antagonize electrogenic convulsions, amphetamine potentiated motility and the action of reserpine, and had no analgetic action." | 1.26 | Central action of new derivatives of tetrahydropirimidinedione-4,6. ( Barczyńska, J; Felsztyńska, J; Kedzierska, L; Wilimowski, M; Witkowska, M; Wojewódzki, W, 1979) |
| "The lack of effect of metrazol convulsions on cerebral taurine in vivo indicates that further studies are needed to clarify the relationship between taurine, a putative inhibitory transmitter, and epilepsy." | 1.26 | Levels and uptake of taurine in various brain regions after drug-induced generalized convulsions. ( Battistin, L; Pistollato, L; Tezzon, F; Varotto, M, 1979) |
| "The hypothesis that the seizure susceptibility of chronically denervated cortex is due to interruption of recurrent inhibitory pathways was tested by examining the release of 3H-labeled gamma-aminobutyric acid ([3H]GABA) from chronic slabs and normal cortex of cats." | 1.26 | Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex. ( Reiffenstein, RJ, 1979) |
| "5." | 1.26 | The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam. ( Anhut, H; Hertting, G; Steinhauer, HB, 1979) |
| "The two behavioral seizure models tested, 6 Hz ECS and pentylenetetrazol, were unable to differentiate between exposed and unexposed animals, even at severe concentrations of CO (55% HbCO)." | 1.26 | Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia. ( Annau, Z; Burden, E; Dyer, RS; Hulebak, K; Schultz, N; Swartzwelder, HS, 1979) |
| "Bicuculline was found to augment PhADs in a manner similar to that found with pentylenetetrazol, with the exception that potentiation only occurred at convulsive levels whereas pentylenetetrazol augmentation occurred at both subconvulsive and convulsive levels." | 1.26 | Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges. ( Bigler, ED, 1977) |
| "Comparison of the PD50 from clonic seizure at the peak-effect hours revealed that the benzodiazepines were 16 to 96 times more potent than phenobarbitone on a molar basis, while phenobarbitone itself was 12 to 26 times more potent than ethosuximide and trimethadione." | 1.26 | The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats. ( Banerjee, U; Yeoh, PN, 1977) |
| "Generalized EEG seizures were induced in acute, conscious New Zealand albino rabbits with intravenous pentylenetetrazol (PTZ) (10 or 15 mg/kg) or electrical stimulation of the frontal cerebral cortex (ELEC) (50 Hz, 1 msec pulse duration, 2 sec train duration, 4." | 1.26 | Elevation of seizure thresholds: a comparison of cerebellar stimulation, phenobarbital, and diphenylhydantoin. ( Brockman, WH; Strain, GM; Van Meter, WG, 1978) |
| "n-DPA proved to be most active against convulsions induced by picrotoxin (ED50 200 mg/kg orally), which might indicate a role of the elevation of the central levels of gamma-aminobutyric acid in the anticonvulsant effect of the drug." | 1.26 | Di-n-propylacetic acid--profile of anticonvulsant activity in mice. ( Frey, HH; Löscher, W, 1976) |
| "The data suggest that overt convulsions may be necessary for the development of pentylenetetrazol-induced retrograde amnesia." | 1.26 | Pentylenetetrazol-induced amnesia: a case for overt seizures. ( Albala, B; Palfai, T, 1976) |
| "In DBA/2 mice, seizures following auditory stimulation were attenuated or abolished by NPA 0." | 1.26 | Inhibition of reflex epilepsy by (+/-)-N-n-propylnorapomorphine. ( Anlezark, G; Ashton, C; Meldrum, B, 1976) |
| "During seizure activity there was a calcium dependent increase in ACh efflux which was related to increase EEG activity and clonic muscle movements." | 1.26 | Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release. ( Gardner, CR; Webster, RA, 1977) |
| "During seizures an increase of K+e occurred subsequent to the electrical discharges, while during postictal depression of EEG normal levels of K+e were measured." | 1.26 | EEG and extracelluar K+ in rat brain during pentylenetetrazol seizures and during respiratory arrest. ( Astrup, J; Bolwig, TG; Christoffersen, GR, 1977) |
| "In rats showing these violent convulsions, the PTZ convulsive threshold was decreased and, even after a 4- to 10-month resting period, the violent convulsion was elicited with the same dose of PTZ." | 1.26 | Effect of anticonvulsants on seizures developing in the course of daily administration of pentetrazol to rats. ( Hori, M; Ito, T; Shimizu, M; Yoshida, K, 1977) |
| "During metrazol or strychnine-induced convulsions a diffuse decrease in ACh levels was found in rats killed by decapitation." | 1.26 | Changes in regional brain acetylcholine levels during drug-induced convulsions. ( Mulas, A; Pedata, F; Pepeu, G; Pepeu, IM, 1976) |
| "Paperine slightly lowers the convulsive-seizure reactivity only in pentylenetetrazol convulsions." | 1.26 | Experimental study of the effects of imidazol, papaverine and histamine on convulsive-seizure reactivity. ( Atanassova-Shopova, S; Lazarova, M; Roussinov, KS, 1976) |
| "Distinct convulsions were induced by 30--50 mg." | 1.26 | Behavioral and physiological studies of seizures induced by systemic injection of metrazol in chickens. ( Ookawa, T; Takagi, K, 1976) |
| "Epileptiform convulsions occurred in presentation of "difficult" experimental tasks." | 1.26 | [Characteristics of the function of the higher portions of the central nervous system of rats subjected to acute hypoxia in the antenatal period]. ( Kruglikov, RI; Maĭzelis, MIa; Zabludovskiĭ, AL, 1976) |
| "Clorazepate dipotassium and diazepam were administered daily for the first 5 days of each week to Rhesus monkeys at equimolar doses and challanged once a week with a convulsant dose of pentylenetetrazol." | 1.25 | Comparison of anticonvulsant effects of clorazepate dipotassium and diazepam. Four week anticonvulsant study in Rhesus monkeys. ( O'Brien, GS; Plotnikoff, NP, 1974) |
| "It is concluded that seizure-induced depolarization of neural elements in deep cortical layers, though inadequate to trigger spreading depression, does prevent it from spreading, in part by activating the sodium pump." | 1.25 | Blockage of cortical spreading depression by picrotoxin foci of paroxysmal activity. ( Borzek, G; Bures, J; von Schwarzenfeld, I, 1975) |
| "Pentylenetetrazol (PTZ)-induced convulsions were not inhibited by either ergotamine or methysergide but each drug interacted with PTZ to induce lethality, which is suggestive evidence of central 5-HT antagonist activity." | 1.25 | The effect of ergotamine and methysergide on serotonin metabolism in the rat brain. ( Sofia, RD; Vassar, HB, 1975) |
| "The effect of convulsions caused by injections of metrazol on the kinetics of 32P uptake in the brain is described." | 1.25 | In vivo measurement of 32P in the brain of a freely moving rat. ( Ewins, JH; Friedland, SS; Mayevsky, A; Samuel, D, 1975) |
| "Tonic seizure was seen at birth, myoclonic jerks at 2 weeks of age, myoclonic seizure and catalepsy at 3 weeks of age." | 1.25 | Maturation of convulsogenic activity induced by leptazol in the albino rat. ( de Casrilevitz, M; Engelhardt, E; Esbérard, CA, 1971) |
| "Leptazol B." | 1.24 | Effect of aldosterone and cortisol on leptazol-induced seizures in rats. ( SELLER, MJ; SPECTOR, RG, 1962) |
| "However, the effects of reserpine on convulsions due to leptazol and in causing ptosis were not antagonized by methyldopa." | 1.24 | INFLUENCE OF METHYLDOPA ON CENTRAL EFFECTS OF RESERPINE. ( BENFEY, BG; VARMA, DR, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1215 (35.35) | 18.7374 |
| 1990's | 490 (14.26) | 18.2507 |
| 2000's | 575 (16.73) | 29.6817 |
| 2010's | 859 (24.99) | 24.3611 |
| 2020's | 298 (8.67) | 2.80 |
| Authors | Studies |
|---|---|
| Azam, F | 1 |
| Alkskas, IA | 1 |
| Khokra, SL | 1 |
| Prakash, O | 1 |
| Hussain, M | 1 |
| Rashid, H | 1 |
| Katyal, J | 5 |
| Cetindag Ciltas, A | 1 |
| Ozdemir, E | 4 |
| Gumus, E | 3 |
| Taskiran, AS | 6 |
| Gunes, H | 4 |
| Arslan, G | 2 |
| Fayed, EA | 1 |
| Ragab, A | 1 |
| Ezz Eldin, RR | 1 |
| Bayoumi, AH | 2 |
| Ammar, YA | 1 |
| Ping, X | 1 |
| Chai, Z | 1 |
| Wang, W | 7 |
| Ma, C | 1 |
| White, FA | 1 |
| Jin, X | 1 |
| Aghaie, F | 2 |
| Rajabi, M | 2 |
| Hosseini, A | 5 |
| Moradifar, F | 1 |
| Koneshlou, S | 1 |
| Mumtaz, F | 1 |
| Rashki, A | 1 |
| Imran Khan, M | 2 |
| Shadboorestan, A | 2 |
| Abdollahi, A | 1 |
| Ghazi-Khansari, M | 2 |
| Alotaibi, G | 1 |
| Dehpour, AR | 81 |
| da Silva, TVN | 1 |
| Torres, MF | 2 |
| Sampaio, LA | 1 |
| Hamoy, M | 6 |
| Monserrat, JM | 1 |
| Barbas, LAL | 4 |
| Feja, M | 1 |
| Meller, S | 1 |
| Deking, LS | 1 |
| Kaczmarek, E | 1 |
| During, MJ | 1 |
| Silverman, RB | 1 |
| Gernert, M | 4 |
| Pahwa, P | 2 |
| Singh, T | 6 |
| Goel, RK | 10 |
| Knox, KM | 1 |
| Zierath, DK | 1 |
| White, HS | 13 |
| Barker-Haliski, M | 2 |
| Wang, L | 12 |
| Ding, J | 2 |
| Zhu, C | 2 |
| Guo, B | 1 |
| Yang, W | 1 |
| He, W | 2 |
| Li, X | 10 |
| Wang, Y | 25 |
| Li, W | 7 |
| Wang, F | 4 |
| Sun, T | 1 |
| Gwedela, MNV | 1 |
| Terai, H | 1 |
| Lampiao, F | 1 |
| Matsunami, K | 1 |
| Aizawa, H | 2 |
| Ren, Q | 2 |
| Gao, D | 1 |
| Mou, L | 2 |
| Zhang, S | 11 |
| Zhang, M | 4 |
| Li, N | 1 |
| Sik, A | 3 |
| Jin, M | 6 |
| Liu, K | 6 |
| Taskiran, M | 1 |
| Unal, G | 1 |
| de Calbiac, H | 1 |
| Dabacan, A | 1 |
| Muresan, R | 1 |
| Kabashi, E | 1 |
| Ciura, S | 1 |
| Kozioł, E | 2 |
| Jóźwiak, K | 1 |
| Budzyńska, B | 2 |
| de Witte, PAM | 3 |
| Copmans, D | 3 |
| Skalicka-Woźniak, K | 2 |
| Singh, S | 3 |
| Singh, TG | 4 |
| Singh, M | 2 |
| Najda, A | 1 |
| Nurzyńska-Wierdak, R | 1 |
| Almeer, R | 2 |
| Kamel, M | 1 |
| Abdel-Daim, MM | 1 |
| Bora, ES | 1 |
| Karaali, R | 1 |
| Akyol, PY | 1 |
| Yurtsever, G | 1 |
| Erbaş, O | 15 |
| Shmakova, AA | 2 |
| Rysenkova, KD | 2 |
| Ivashkina, OI | 2 |
| Gruzdeva, AM | 2 |
| Klimovich, PS | 1 |
| Popov, VS | 1 |
| Rubina, KA | 2 |
| Anokhin, KV | 2 |
| Tkachuk, VA | 2 |
| Semina, EV | 2 |
| Wu, J | 2 |
| Hou, Z | 1 |
| Chen, L | 10 |
| Lian, C | 1 |
| Meng, Q | 1 |
| Zhang, C | 7 |
| Huang, L | 2 |
| Yu, H | 4 |
| Barbosa, MOR | 1 |
| de Paulo, MEFDV | 1 |
| Nencioni, ALA | 1 |
| de Lima, AMDL | 1 |
| de Lima Rosa, G | 3 |
| Müller Guzzo, EF | 1 |
| Padilha, RB | 2 |
| Costa da Silva, R | 1 |
| Silveira, AK | 1 |
| de Lima Morales, D | 1 |
| Conci de Araujo, M | 1 |
| Fonseca Moreira, JC | 1 |
| Barth, AL | 2 |
| Coitinho, AS | 5 |
| Van Der Sand, ST | 1 |
| Uttl, L | 1 |
| Hložek, T | 1 |
| Mareš, P | 65 |
| Páleníček, T | 1 |
| Kubová, H | 23 |
| Khatami, P | 3 |
| Mirazi, N | 5 |
| Khosravi, M | 2 |
| Bananej, M | 2 |
| Wang, Q | 4 |
| Wu, D | 1 |
| Zhang, DW | 1 |
| Li, SC | 1 |
| Zhang, SW | 1 |
| Chen, X | 5 |
| Nagib, MM | 2 |
| Yasmen, N | 1 |
| Li, L | 5 |
| Hou, R | 1 |
| Yu, Y | 2 |
| Boda, VK | 1 |
| Wu, Z | 3 |
| Jiang, J | 1 |
| Wang, X | 18 |
| Guo, Z | 1 |
| Mei, D | 1 |
| Zhang, Y | 12 |
| Zhao, S | 1 |
| Hu, S | 1 |
| Luo, S | 1 |
| Gao, C | 1 |
| Riban, V | 1 |
| Heulard, I | 1 |
| Reversat, L | 1 |
| Si Hocine, H | 1 |
| Verleye, M | 1 |
| De La Rossa, A | 1 |
| Laporte, MH | 1 |
| Astori, S | 1 |
| Marissal, T | 1 |
| Montessuit, S | 1 |
| Sheshadri, P | 1 |
| Ramos-Fernández, E | 1 |
| Mendez, P | 1 |
| Khani, A | 1 |
| Quairiaux, C | 1 |
| Taylor, EB | 1 |
| Rutter, J | 1 |
| Nunes, JM | 1 |
| Carleton, A | 1 |
| Duchen, MR | 1 |
| Sandi, C | 1 |
| Martinou, JC | 1 |
| Janisset, NRLL | 1 |
| Romariz, SAA | 3 |
| Hashiguchi, D | 1 |
| Quintella, ML | 1 |
| Gimenes, C | 1 |
| Yokoyama, T | 1 |
| Filev, R | 1 |
| Carlini, E | 1 |
| Barbosa da Silva, R | 1 |
| Faber, J | 1 |
| Longo, BM | 2 |
| Leitão, DS | 1 |
| Andrade, AR | 1 |
| Medeiros, NCL | 1 |
| Martins, MFC | 1 |
| Ferreira, LO | 1 |
| Santos, VC | 1 |
| Hamoy, AO | 3 |
| Muto, NA | 1 |
| Jóia de Mello, V | 1 |
| Lopes, DCF | 2 |
| Torun, IE | 4 |
| Kılınc, YB | 1 |
| Kilinc, E | 5 |
| Pala, M | 2 |
| Meral, I | 2 |
| Pala Acikgoz, N | 2 |
| Gorucu Yilmaz, Ş | 2 |
| Taslidere, E | 1 |
| Okur, SK | 2 |
| Acar, S | 2 |
| Akbas, F | 2 |
| Wu, L | 1 |
| Qin, Y | 1 |
| Yuan, H | 1 |
| Zhu, Y | 1 |
| Hu, A | 1 |
| Tsai, CM | 2 |
| Chang, SF | 2 |
| Chang, H | 4 |
| Nishi, T | 1 |
| Metcalf, CS | 1 |
| Fujimoto, S | 1 |
| Hasegawa, S | 1 |
| Miyamoto, M | 1 |
| Sunahara, E | 1 |
| Watanabe, S | 3 |
| Kondo, S | 1 |
| Huang, Y | 3 |
| Xu, H | 1 |
| Wang, P | 2 |
| Gu, R | 1 |
| Xu, Y | 1 |
| Wang, J | 3 |
| Qiao, S | 1 |
| Shi, D | 1 |
| Gao, Z | 1 |
| Li, J | 7 |
| Lu, HC | 1 |
| Chang, WJ | 1 |
| Wei Huang, AC | 1 |
| Shyu, BC | 1 |
| Siddiqui, MA | 1 |
| Asad, M | 1 |
| Akhter, J | 1 |
| Hoda, U | 2 |
| Rastogi, S | 1 |
| Arora, I | 1 |
| Aggarwal, NB | 1 |
| Samim, M | 1 |
| Zhou, L | 2 |
| Gao, Y | 1 |
| Lu, H | 3 |
| Liu, W | 2 |
| Xu, X | 4 |
| Xing, B | 1 |
| Liang, X | 1 |
| Wang, N | 2 |
| Jiang, X | 4 |
| Zhao, Q | 1 |
| Rahimi, N | 14 |
| Modabberi, S | 1 |
| Faghir-Ghanesefat, H | 4 |
| Shayan, M | 3 |
| Farzad Maroufi, S | 1 |
| Asgari Dafe, E | 1 |
| Sahin, B | 2 |
| Ergul, M | 4 |
| Shaw, PAG | 1 |
| Panda, SK | 1 |
| Stanca, A | 1 |
| Luyten, W | 3 |
| Aygun, H | 2 |
| Akin, AT | 1 |
| Kızılaslan, N | 1 |
| Sumbul, O | 1 |
| Karabulut, D | 1 |
| Karabulut, S | 1 |
| Filiz, AK | 1 |
| Akkaya, R | 1 |
| Hosseinzadeh, A | 3 |
| Dehdashtian, E | 2 |
| Jafari-Sabet, M | 1 |
| Mehrzadi, S | 4 |
| Taghizad, S | 1 |
| Behbahaninia, K | 1 |
| Jahromy, MH | 1 |
| Davood, A | 3 |
| Rahimi-Madiseh, M | 2 |
| Lorigooini, Z | 4 |
| Boroujeni, SN | 1 |
| Taji, M | 1 |
| Amini-Khoei, H | 8 |
| da Guedes, E | 1 |
| Ribeiro, LR | 12 |
| Carneiro, CA | 1 |
| Santos, AMF | 1 |
| Brito Monteiro, Á | 1 |
| de Andrade, HHN | 1 |
| Castro, RD | 1 |
| Barbosa, FF | 1 |
| Barbosa Filho, JM | 1 |
| de Almeida, RN | 8 |
| Stiebbe Salvadori, MG | 1 |
| Wen, Y | 2 |
| Zhang, G | 1 |
| Liu, L | 4 |
| Zhang, P | 3 |
| Lin, L | 3 |
| Mei, R | 3 |
| Zhang, F | 3 |
| Chen, Y | 12 |
| Li, R | 6 |
| Liu, J | 7 |
| Sahin, H | 1 |
| Yucel, O | 1 |
| Emik, S | 1 |
| Senturk, GE | 1 |
| Chen, J | 5 |
| Li, Y | 13 |
| Bertoncello, KT | 2 |
| Zanandrea, R | 1 |
| Bonan, CD | 7 |
| Pedroso, J | 3 |
| Schneider, SE | 4 |
| Lima-Rezende, CA | 3 |
| Aguiar, GPS | 4 |
| Müller, LG | 4 |
| Oliveira, JV | 3 |
| Piato, A | 4 |
| Siebel, AM | 8 |
| Rzayev, E | 1 |
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| Doboszewska, U | 7 |
| Sawicki, J | 2 |
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| Szopa, A | 3 |
| Serefko, A | 3 |
| Socała, K | 23 |
| Pieróg, M | 11 |
| Nieoczym, D | 20 |
| Mlyniec, K | 2 |
| Nowak, G | 2 |
| Barałkiewicz, D | 2 |
| Sowa, I | 2 |
| Wlaź, P | 23 |
| Dos Santos Heringer, L | 1 |
| Rios Carvalho, J | 1 |
| Teixeira Oliveira, J | 1 |
| Texeira Silva, B | 1 |
| de Souza Aguiar Dos Santos, DM | 1 |
| Martinez Martinez Toledo, AL | 1 |
| Borges Savoldi, LM | 1 |
| Magalhães Portela, D | 1 |
| Adriani Marques, S | 1 |
| Campello Costa Lopes, P | 1 |
| Blanco Martinez, AM | 1 |
| Rocha Mendonça, H | 1 |
| Boroujeni, SS | 1 |
| Solaimanian, S | 2 |
| Jafari, RM | 1 |
| Sabzevari, O | 1 |
| Shafaroodi, H | 33 |
| Maleki, A | 1 |
| Mohammadi, P | 1 |
| Karimi, E | 1 |
| Alyami, NM | 1 |
| Abdi, S | 1 |
| Alyami, HM | 1 |
| Zhao, X | 1 |
| Cheng, P | 1 |
| Xu, R | 1 |
| Meng, K | 1 |
| Liao, S | 1 |
| Jia, P | 1 |
| Zheng, X | 4 |
| Xiao, C | 1 |
| Olubodun-Obadun, TG | 1 |
| Ishola, IO | 1 |
| Ben-Azu, B | 1 |
| Afolayan, O | 1 |
| Nwose, E | 1 |
| James, AB | 1 |
| Ajayi, AM | 1 |
| Umukoro, S | 1 |
| Adeyemi, OO | 1 |
| Dhillon, HK | 1 |
| Wilson, CD | 1 |
| Zheng, F | 3 |
| Fantegrossi, WE | 1 |
| Radpour, M | 1 |
| Choopani, S | 1 |
| Pourbadie, HG | 1 |
| Sayyah, M | 15 |
| Abd El-Aal, SA | 1 |
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| Erdogan, MA | 6 |
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| Smolders, I | 7 |
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| Wang, Z | 6 |
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| da Silva, MCM | 1 |
| Vilela, LR | 3 |
| Moreira, FA | 3 |
| Moraes, MFD | 4 |
| de Oliveira, ACP | 1 |
| Hao, L | 1 |
| Peng, X | 1 |
| Yang, M | 4 |
| Guo, Y | 4 |
| Jing, W | 1 |
| Guzzo, EFM | 1 |
| Nunes, SEB | 1 |
| Domingues, AM | 1 |
| Barbosa, BB | 1 |
| Siqueira, IR | 1 |
| Eslami, F | 1 |
| Amanlou, A | 1 |
| Rashidian, A | 2 |
| Ejtemaei-Mehr, S | 2 |
| Ghasemi, M | 22 |
| Mohammadi, AA | 1 |
| Taheri, S | 2 |
| Shisheboran, S | 1 |
| Ahdenov, R | 1 |
| Mohammadi-Khanaposhtani, M | 2 |
| Darjani, PS | 1 |
| Masihi, PH | 1 |
| Shakiba, A | 2 |
| Larijani, B | 1 |
| Mahdavi, M | 2 |
| Ahangar, N | 4 |
| Muhammad Bello, A | 1 |
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| Samaila Malgwi, I | 1 |
| Musa Chiroma, S | 1 |
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| Chen, S | 4 |
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| Jia, D | 1 |
| Li, Q | 3 |
| Azevedo, JEC | 2 |
| da Silva, ALM | 1 |
| Vieira, LR | 2 |
| Nascimento, CP | 2 |
| Pereira, RG | 1 |
| Rodrigues, SF | 1 |
| Mello, VJ | 1 |
| Araújo, DB | 1 |
| Lopez, MEC | 1 |
| Polat, Y | 1 |
| Romero-Guerrero, C | 1 |
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| Rafieian-Kopaei, M | 2 |
| Alhamzani, AG | 1 |
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| Raghu, MS | 1 |
| Yogesh Kumar, K | 1 |
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| Wang, G | 1 |
| Lu, J | 2 |
| Li, Z | 6 |
| Postnikova, TY | 3 |
| Trofimova, AM | 2 |
| Zakharova, MV | 2 |
| Nosova, OI | 1 |
| Brazhe, AR | 1 |
| Korzhevskii, DE | 1 |
| Semyanov, AV | 1 |
| Zaitsev, AV | 6 |
| Jourian, S | 3 |
| Rahimi, M | 3 |
| Manavi, MA | 3 |
| Pahlevan-Fallahy, MT | 3 |
| Mohammad Jafari, R | 5 |
| Amini, A | 4 |
| Zhuang, XF | 3 |
| Liu, YX | 3 |
| Yang, ZH | 3 |
| Gao, Q | 3 |
| Ju, C | 3 |
| Wang, K | 4 |
| Heydari, FS | 3 |
| Gorji Valokola, M | 3 |
| Mehri, S | 3 |
| Abnous, K | 3 |
| Roohbakhsh, A | 6 |
| Shtrygol, S | 3 |
| Zalevskyi, S | 3 |
| Mishchenko, M | 3 |
| Shtrygol, D | 3 |
| Severina, H | 3 |
| Kayal, WE | 3 |
| Georgiyants, V | 3 |
| Hu, Y | 6 |
| Meng, B | 3 |
| Yin, S | 3 |
| Liu, N | 3 |
| Li, S | 5 |
| Liu, Y | 11 |
| Sun, D | 4 |
| Fu, Z | 4 |
| Wu, Y | 6 |
| Pang, A | 3 |
| Sun, J | 3 |
| Yang, X | 6 |
| Gurgul, S | 3 |
| Ayala-Guerrero, F | 3 |
| Castro-Domínguez, D | 2 |
| Mateos-Salgado, EL | 2 |
| Mexicano-Medina, G | 2 |
| Gutiérrez-Chávez, CA | 2 |
| Adassi, MB | 2 |
| Ngoupaye, GT | 6 |
| Yassi, FB | 3 |
| Foutsop, AF | 3 |
| Kom, TD | 3 |
| Ngo Bum, E | 7 |
| Zhang, XL | 2 |
| Zhou, JY | 2 |
| Zhang, FL | 2 |
| Chen, YM | 3 |
| Danis, A | 1 |
| Baranoglu Kilinc, Y | 1 |
| Hanci, F | 1 |
| Ankarali, H | 2 |
| Dehkordi, HT | 1 |
| Bijad, E | 2 |
| Saghaei, E | 1 |
| Korrani, MS | 1 |
| Rezaei, M | 1 |
| Raoufy, MR | 1 |
| Fathollahi, Y | 3 |
| Shojaei, A | 4 |
| Mirnajafi-Zadeh, J | 6 |
| Sivarajan, D | 1 |
| Ramachandran, B | 1 |
| Szewczyk, B | 1 |
| Vega Rasgado, LA | 2 |
| Ramón-Gallegos, E | 1 |
| Rodríguez-Páez, L | 1 |
| Alcántara-Farfán, V | 1 |
| Tavakoli, Z | 1 |
| Tahmasebi Dehkordi, H | 1 |
| Korani, MS | 1 |
| Feng, G | 1 |
| Liu, X | 13 |
| Wang, B | 3 |
| Chang, Y | 1 |
| Guo, N | 1 |
| Chen, T | 3 |
| Ma, B | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study[NCT05881928] | Phase 4 | 50 participants (Anticipated) | Interventional | 2023-07-25 | Not yet recruiting | ||
| A Phase 2 Clinical Trial Testing the Safety and Efficacy of Voronistat in Pediatric Patients With Drug Resistant Epilepsy[NCT03894826] | Phase 2 | 12 participants (Anticipated) | Interventional | 2018-12-10 | Recruiting | ||
| Phase 2a Levetiracetam Trial for AD-Associated Network Hyperexcitability[NCT02002819] | Phase 2 | 34 participants (Actual) | Interventional | 2014-10-16 | Completed | ||
| Randomized, Double Blind, Placebo Controlled, Parallel Design Phase II b Study of Safety and Efficacy of MGCND00EP1 as an Add on Treatment in Children and Adolescents With Resistant Epilepsies[NCT04406948] | Phase 2 | 103 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | ||
| Role of Testosterone and Its Metabolites Regarding Different Physiological Functions in Subjects Affected by Gender Identity Disorder (FtM Transsexuals)[NCT00146146] | Phase 3 | 15 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) - The ADAS-cog rating instrument (Rosen et al. 1984) will be used to evaluate the global cognitive functioning. The ADAS-cog is a 70-point scale that includes an assessment of verbal memory, language, orientation, reasoning, and praxis.The score is derived from adding point values from each of its subsections. The higher your score on the ADAS-cog, the better you do. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam (Epileptiform Activity) | -1.0 |
| Placebo (Epileptiform Activity) | 1.5 |
Blood samples intended for Quest Diagnostics LEV and prolactin serum levels (one 6 mL tube) will be processed in the following manner, as outlined in the Quest Diagnostics lab manual. The whole blood will be allowed to clot for 60 minutes and centrifuged at 2200 - 2500 revolutions per minute (RPM) for at least 15 minutes. The resulting serum will be split into 2 cryovials which will be stored at -20°C and immediately shipped for external assessment of LEV and prolactin levels. Prolactin will be assessed via immunoassay. The concentration of LEV in serum will be measured using validated liquid chromatography/tandem mass spectrometry (LC/MS-MS) methods. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | ng/mL (Mean) |
|---|---|
| Levetiracetam | 0.1 |
| Placebo | 0.2 |
Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) - The ADAS-cog rating instrument (Rosen et al. 1984) will be used to evaluate the global cognitive functioning. The ADAS-cog is a 70-point scale that includes an assessment of verbal memory, language, orientation, reasoning, and praxis.The score is derived from adding point values from each of its subsections. The higher your score on the ADAS-cog, the better you do. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.2 |
| Placebo | 0.8 |
Alzheimer's Disease Cooperative Study Activities of Daily Living Scale (ADCS-ADL) - The ADCS-ADL rating instrument (Galasko et al. 1997) will be used to evaluate functional capacity. The ADCS-ADL is a caregiver rated questionnaire. Scores on the 24-item ADCS-ADL range from 0 to 78. A higher score indicates less severity while a lower score indicates greater severity. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.4 |
| Placebo | 0.3 |
ADCS-Clinical Global Impression of Change (ADCS-CGIC) - The ADCS-CGIC is a seven-point scale that gives a global rating of change from baseline (Schneider et al. 1997). The baseline and follow up assessments are based on interviews with the subject and the informant. The ADCS-CGIC is a clinician-rated measure of: global severity at baseline scored from 1 (normal, not at all ill) to 7 (among the most extremely ill patients); and global change at follow-up scored from 1 (marked improvement) to 7 (marked worsening), where 4 indicates no change. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 4.0 |
| Placebo | 4.0 |
Neuropsychiatric Inventory (NPI) - The NPI (Cummings et al. 1994) will be used to evaluate the severity of behavioral symptoms. The severity scale has scores ranging from 1 to 3 points (1=mild; 2=moderate; and 3=severe) and the scale for assessing caregiver distress has scores ranging from 0 to 5 points (0=no distress; 1=minimal distress; 2=mild distress; 3=moderate distress; 4=severe distress; and 5=extreme distress). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.8 |
| Placebo | 0.2 |
A 20-minute computer-based virtual navigation test will be used to assess how well a subject can navigate a virtual community to reach a goal destination. The subjects will then be measured on their ability to accurately navigate the virtual community after a period of a few hours. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | correct turns (Mean) |
|---|---|
| No Epileptiform Activity | -6.0 |
| Epileptic Activity | 17.4 |
"Epileptiform activity will be measured using a 1-hr resting magnetoencephalogram/electroencephalogram (M/EEG). M/EEG can detect abnormal epileptiform findings called spikes. The M/EEG will be read by an epileptologist with specialized training to assess whether there are any spikes. If spikes are observed during the M/EEG they will be counted to determine their frequency (e.g., 5 spikes per 1 hour recording). The frequency of spikes will then be compared to baseline values from before beginning the study treatment, using statistical tests to determine if the frequency changed with treatment." (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | Epileptiform events (Mean) |
|---|---|
| Levetiracetam | -0.1 |
| Placebo | -0.2 |
Changes in executive function were measured using the NIH EXAMINER, a 1-hour computer-based battery of various executive function tasks. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. The Examiner assessment consists of the following scales: antisaccade , set shifting , flanker task, dot counting, spatial 1-back, category fluency, and letter fluency. Scores for this task have an indefinite range. Higher scores however do indicate better performance. Scores for this scale were generated using item response theory. For this study, scores with SEs greater than 0.55 were classified as unreliable and excluded from analysis. Composite scores from 2 participants were excluded on this basis.The EXAMINER ranges for the participants in the study were -2.59 to 1.33. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.06 |
| Placebo | -0.14 |
Stroop Test - The Stroop Test (Stroop 1935) will be used to assess executive functions including selective attention, cognitive flexibility and processing speed. Subtasks include Stroop color naming and Stroop interference naming, and each subtask is restricted to 1 minute. The minimum score is 0 and the maximum score is 126. The higher the score the better a participant does. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 1.5 |
| Placebo | -1.4 |
Clinical Dementia Rating Sum of Boxes (CDR-SOB) - The CDR will be used as a global measure of dementia severity (Morris 1993). The CDR consists of questions addressed to the caregiver/informant. The lowest score one can receive is a 0 and the highest is a 3. Score is measured by getting the mean of the individual scores in each category. Lower scores equate to less dementia severity. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.1 |
| Placebo | 0.1 |
Changes in executive function will be measured using the NIH EXAMINER, a 1-hour computer-based battery of various executive function tasks. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. The Examiner assessment consists of the following scales: NIH EXAMINER - antisaccade , NIH EXAMINER - set shifting , NIH EXAMINER - flanker task, NIH EXAMINER - dot counting, NIH EXAMINER - spatial 1-back, NIH EXAMINER - category fluency, and NIH EXAMINER - letter fluency. Scores for this task have an indefinite range. Higher scores however do indicate better performance. Scores for this scale were generated using item response theory (Kramer et al. J Int Neuropsychol Soc. 2014;20(1):11-19. doi:10.1017/S1355617713001094). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| No Epileptiform Activity | -0.01 |
| Epileptiform Activity | 0.22 |
The One Day Fluctuation Assessment Scale will be used to quantitate fluctuations of dementia symptoms (Walker et al. 2000). The One Day Fluctuation Assessment Scale has a score range of 0-21 points,with higher scores indicatingmore fluctuations. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.3 |
| Placebo | -0.4 |
Two standardized methods will be used to quantitate fluctuations of dementia symptoms: The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale (Walker et al. 2000). : The Clinician Assessment of Fluctuation (score range,0-12 points, with higher scores indicating more fluctuations),26 the One Day Fluctuation Assessment Scale (score range,0-21 points, with higher scores indicatingmore fluctuations). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.9 |
| Placebo | 0.1 |
Stroop Test - The Stroop Test (Stroop 1935) will be used to assess executive functions including selective attention, cognitive flexibility and processing speed. Subtasks include Stroop color naming and Stroop interference naming, and each subtask is restricted to 1 minute. The minimum score is 0 and the maximum score is 126. The higher the score the better a participant does. The mean below represents the average change in score between the timepoints for all participants. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam (Epileptiform Activity) | 4.7 |
| Placebo (Epileptiform Activity) | -2.6 |
30 reviews available for pentylenetetrazole and Absence Seizure
| Article | Year |
|---|---|
Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions.
Topics: Animals; Anticonvulsants; Child; Disease Models, Animal; Epilepsy; Humans; Pentylenetetrazole; Seizu | 2023 |
Chemically-induced epileptic seizures in zebrafish: A systematic review.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Reproducibility of Results; Seizures; Zebraf | 2023 |
Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; | 2020 |
[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor].
Topics: Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Regulation; Epilepsy; Isoxa | 2019 |
Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Memory D | 2020 |
Factors influencing the acute pentylenetetrazole-induced seizure paradigm and a literature review.
Topics: Age Factors; Animals; Convulsants; Electroencephalography; Female; Male; Mice; Mice, 129 Strain; Mic | 2021 |
Neuropathological profile of the pentylenetetrazol (PTZ) kindling model.
Topics: Animals; Convulsants; Disease Models, Animal; Hippocampus; Humans; Kindling, Neurologic; Neurons; Pe | 2018 |
The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely?
Topics: Animals; Electroconvulsive Therapy; Flurothyl; Humans; Memory Disorders; Mental Disorders; Pentylene | 2014 |
METHODS AND CONSIDERATIONS FOR EXPERIMENTAL EVALUATION OF ANTIEPILEPTIC DRUGS.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Pentylenetetrazole; Seizures | 1999 |
The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroshock; Epilep | 2017 |
Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy.
Topics: Animals; Anticonvulsants; Arrhythmias, Cardiac; Cardiotonic Agents; Convulsants; Death, Sudden, Card | 2009 |
Possible therapeutic effects of transcutaneous electrical stimulation via concentric ring electrodes.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes; Penicillin G; Pentylenetetrazole; Pilocarp | 2010 |
Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electro | 2002 |
Androgens in the hippocampus can alter, and be altered by, ictal activity.
Topics: Androgens; Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; Humans; Male; Pentylenete | 2004 |
Chemoconvulsant-induced seizure susceptibility: toward a common genetic basis?
Topics: Animals; Carbolines; Chromosome Mapping; Chromosomes; Convulsants; GABA Agonists; Genetic Predisposi | 2007 |
Changes in CNS sensitivity to cannabinoids with repeated treatment: tolerance and auxoesthesia.
Topics: Animals; Brain; Cannabidiol; Cannabinoids; Dronabinol; Drug Tolerance; Electroshock; Kindling, Neuro | 1984 |
Differential pharmacological effects of benzodiazepine receptor inverse agonists.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Carbolines; Convulsants; Electroshock; Human | 1983 |
[Status of active and passive cation transport through cerebral synaptic membranes during seizures].
Topics: Animals; Anticonvulsants; Brain; Cell Membrane Permeability; Cerebral Cortex; Electric Stimulation; | 1981 |
[Cellular mechanism of seizure discharge and its normalization by a herbal mixture prescription "saikokeishito-ka-shakuyaku" (SK)].
Topics: Animals; Calcium; Cells, Cultured; Chromosome Mapping; Disease Models, Animal; Drug Resistance; Drug | 2001 |
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Aci | 1975 |
Behavioral and electroencephalographic manifestations of avian epilepsy: a review of the literature.
Topics: Animals; Behavior, Animal; Bird Diseases; Birds; Brain; Chickens; Coturnix; Electric Stimulation; El | 1977 |
Audiogenic seizure susceptible rats.
Topics: Acoustic Stimulation; Aging; Aluminum Hydroxide; Animals; Anticonvulsants; Behavior, Animal; Brain; | 1979 |
Spontaneous convulsions in beagle dogs.
Topics: Amino Acids; Animals; Brain; Cerebral Cortex; Dogs; Dronabinol; Electric Stimulation; Electroencepha | 1979 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
CNS effects of convulsive therapy: significance for a theory of depressive psychosis.
Topics: Alpha Rhythm; Amobarbital; Antidepressive Agents; Bipolar Disorder; Brain; Depression; Electroconvul | 1972 |
Pyridoxine dependency and central nervous system excitability.
Topics: Acoustic Stimulation; Aging; Aminobutyrates; Animals; Brain Chemistry; Drug Interactions; Electric S | 1972 |
[Biochemistry of epilepsy].
Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Electroencephalography; Epilepsy; Glutamates; Glutami | 1968 |
[Evaluation of the activation methods in epilepsy].
Topics: Adult; Age Factors; Animals; Bemegride; Cats; Cerebral Cortex; Child; Electric Stimulation; Electroe | 1967 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; El | 1969 |
5 trials available for pentylenetetrazole and Absence Seizure
| Article | Year |
|---|---|
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Avoidance Learning; Convulsants; | 2012 |
Ictal brain SPET during seizures pharmacologically provoked with pentylenetetrazol: a new diagnostic procedure in drug-resistant epileptic patients.
Topics: Adolescent; Adult; Cysteine; Drug Resistance; Electroencephalography; Epilepsy; Feasibility Studies; | 2002 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
[Fluorothyl: pharmacological aspect and clinical use].
Topics: Affective Symptoms; Animals; Bemegride; Bipolar Disorder; Central Nervous System Stimulants; Clinica | 1968 |
Comparable EEG activation by megimide and metrazol.
Topics: Adolescent; Adult; Aged; Bemegride; Body Weight; Clinical Trials as Topic; Electroencephalography; E | 1966 |
3403 other studies available for pentylenetetrazole and Absence Seizure
| Article | Year |
|---|---|
Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Brain Chemistry; Glutathione Peroxidase; Malondialdehyde; Mice; Motor Acti | 2009 |
Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition Disorders; Convulsants; Glutathione; Kindlin | 2021 |
The Anticonvulsant Effects of Alpha-2 Adrenoceptor Agonist Dexmedetomidine on Pentylenetetrazole-Induced Seizures in Rats.
Topics: Animals; Anticonvulsants; Dexmedetomidine; Male; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, | 2022 |
In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Injections | 2021 |
Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Post-Traumatic; Mice; Mice, Knockout; Pentylene | 2021 |
Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway.
Topics: Animals; Epilepsy; Glucosinolates; Inflammation; Male; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
Neuroprotective effect of sumatriptan in pentylenetetrazole-induced seizure is mediated through N-methyl-D-aspartate/nitric oxide and cAMP response element-binding protein signaling pathway.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Mice; N-Methylaspartate; Neuroprotective Agent | 2022 |
Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum.
Topics: Animals; Anticonvulsants; Brain; Characiformes; Diazepam; Diet; Euterpe; Lipid Peroxidation; Pentyle | 2021 |
OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Kindling, Neu | 2021 |
Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Epilepsy, Reflex; Female; Horses; Mice; Pentylenetetrazole; P | 2022 |
Continuous seizure emergency evoked in mice with pharmacological, electrographic, and pathological features distinct from status epilepticus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Emergencies; Glial Fibrillary Acidic Protei | 2021 |
Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice.
Topics: Animals; Apoptosis; Cell Line; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Epilepsy; G | 2021 |
Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae.
Topics: Animals; Anticonvulsants; Larva; Malawi; Medicine, African Traditional; Pentylenetetrazole; Plant Ex | 2022 |
Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy; Gene | 2021 |
Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ-induced kindling rat model.
Topics: Animals; Cognition; Disease Models, Animal; Male; Myoclonus; Pentylenetetrazole; Rats; Rats, Wistar; | 2021 |
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Humans; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Convulsants; Coumarins; Epilepsy; Mesencepha | 2021 |
Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice.
Topics: Animals; Anticonvulsants; Chondroitin Sulfates; Male; Mice; Molecular Docking Simulation; Neuroprote | 2021 |
The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats.
Topics: Animals; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Sulfasalazine | 2021 |
Early Induction of Neurotrophin Receptor and miRNA Genes in Mouse Brain after Pentilenetetrazole-Induced Neuronal Activity.
Topics: Animals; Brain; Cell Survival; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; | 2021 |
Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABA
Topics: Animals; Anticonvulsants; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Electro | 2022 |
Scorpion Envenomation of Lactating Rats Decreases the Seizure Threshold in Offspring.
Topics: Animals; Animals, Newborn; Behavior, Animal; Convulsants; Female; Lactation; Male; Maternal Behavior | 2021 |
Gut microbiota modulation by prednisolone in a rat kindling model of pentylenetetrazol (PTZ)-induced seizure.
Topics: Animals; Gastrointestinal Microbiome; Male; Pentylenetetrazole; Prednisolone; Rats; Rats, Wistar; Se | 2022 |
Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Disease Models, Animal; Epilepsy; Male; N-Methylaspart | 2021 |
Nonsteroidal Anti-inflammatory Drug Oxaprozin is Beneficial Against Seizure-induced Memory Impairment in an Experimental Model of Seizures in Rats: Impact On Oxidative Stress and Nrf2/HO-1 Signaling Pathway.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Male; Memory Disorders; Models, Theo | 2022 |
The effect of a novel anticonvulsant chemical Q808 on gut microbiota and hippocampus neurotransmitters in pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Gastrointestinal Microbiome; Hippocampus; Neurotransmitter Agents; Pentyle | 2022 |
Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.
Topics: Animals; Disease Models, Animal; Mice; Pentylenetetrazole; Pilocarpine; Pyrazoles; Seizures | 2022 |
The GluN2B-Trp373 NMDA Receptor Variant is Associated with Autism-, Epilepsy-Related Phenotypes and Reduces NMDA Receptor Currents in Rats.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Epilepsy; Pentylenetetrazole; Phenotype; Rats; | 2022 |
Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels.
Topics: Animals; Anticonvulsants; Calcium Channels, T-Type; Dioxolanes; Disease Models, Animal; Electroencep | 2022 |
Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency.
Topics: 3-Hydroxybutyric Acid; Animals; Anion Transport Proteins; Biological Transport; Calcium; Gene Expres | 2022 |
Partial protective effects of cannabidiol against PTZ-induced acute seizures in female rats during the proestrus-estrus transition.
Topics: Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Estrus; Female; Humans; Male; Pentyle | 2022 |
Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside.
Topics: Animals; Anticonvulsants; Benzodiazepines; Colchicine; Male; Pentylenetetrazole; Rats; Rats, Wistar; | 2022 |
Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats.
Topics: Animals; Anticonvulsants; Epilepsy; Fluoxetine; Humans; Interleukin-6; Male; Neuroinflammatory Disea | 2022 |
Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus.
Topics: Animals; Benzoquinones; Epilepsy; Hippocampus; Kindling, Neurologic; Male; MicroRNAs; Neuroprotectiv | 2022 |
Anti-inflammatory and neuroprotective effects of insulin-like growth factor-1 overexpression in pentylenetetrazole (PTZ)-induced mouse model of chronic epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Epilepsy; Hippocampus; Insulin-Like Growt | 2022 |
Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats.
Topics: Animals; Anticonvulsants; Humans; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Valproic | 2022 |
Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.
Topics: Animals; Anticonvulsants; Cholesterol 24-Hydroxylase; Disease Models, Animal; Epilepsy; Kindling, Ne | 2022 |
Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation.
Topics: Anticonvulsants; Diterpenes; Electroshock; Epilepsy; Guaifenesin; Humans; Pentylenetetrazole; Seizur | 2022 |
Detection of pentylenetetrazol-induced seizure activity in the 19-21 Hz beta range using a magnetic coil induction method.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Magnetic Phenomena; Mice; Pentyle | 2022 |
Resveratrol-Loaded Glutathione-Coated Collagen Nanoparticles Attenuate Acute Seizures by Inhibiting HMGB1 and TLR-4 in the Hippocampus of Mice.
Topics: Animals; Anticonvulsants; Collagen; Epilepsy; Glutathione; Hippocampus; HMGB1 Protein; Mice; Nanopar | 2022 |
Topics: Alzheimer Disease; Animals; Anticonvulsants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy | 2023 |
Anticonvulsant activity of oxaprozin in a rat model of pentylenetetrazole-induced seizure by targeting oxidative stress and SIRT1/PGC1α signaling.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Glutathione; Myoclonus; Oxaprozin; Oxidative Stres | 2022 |
The possible role of nitric oxide signaling and NMDA receptors in allopurinol effect on maximal electroshock- and pentylenetetrazol-induced seizures in mice.
Topics: Allopurinol; Animals; Anticonvulsants; Arginine; Convulsants; Dizocilpine Maleate; Electroshock; Enz | 2022 |
The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats.
Topics: Animals; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Pheno | 2022 |
Optimization of a locomotion-based zebrafish seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Larva; Locomotio | 2022 |
Electrophysiological, histopathological, and biochemical evaluation of the protective effect of probiotic supplementation against pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Dietary Supplements; Disease Models, Animal; Humans; Interleukin-6; Male; | 2023 |
Thiamine alleviates cognitive impairment and epileptogenesis by relieving brain inflammation in PTZ-induced kindling rat model.
Topics: Animals; Cognitive Dysfunction; Cyclooxygenase 2; Encephalitis; Epilepsy; Kindling, Neurologic; Male | 2022 |
The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice.
Topics: Animals; Anticonvulsants; Cholecalciferol; Disease Models, Animal; Epilepsy; Melatonin; Mice; Pentyl | 2022 |
Pyrrolopyridine and Isoindole as Potential Anticonvulsant Agents: Design, Synthesis, and Pharmacological Evaluation.
Topics: Amines; Anhydrides; Anticonvulsants; Electroshock; Humans; Isoindoles; Pentylenetetrazole; Phenytoin | 2022 |
The Role of the NMDA Receptor in the Anticonvulsant Effect of Ellagic Acid in Pentylenetetrazole-Induced Seizures in Male Mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Ellagic Acid; Ketamine; Male; Mice; N-Me | 2022 |
Anticonvulsant Activity of
Topics: Allylbenzene Derivatives; Animals; Anisoles; Anticonvulsants; Disease Models, Animal; Dose-Response | 2022 |
HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABA
Topics: 14-3-3 Proteins; Animals; Epilepsy; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Pentylenetetrazo | 2022 |
Simultaneous determination of four cobalamins in rat plasma using online solid phase extraction coupled to high performance liquid chromatography-tandem mass spectrometry: Application to pentylenetetrazole-induced seizures in Sprague-Dawley rats.
Topics: Animals; Chromatography, High Pressure Liquid; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizu | 2022 |
Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Male; Nanoparticles; Neurogenesis; Neurons; | 2022 |
miR-146a/KLF4 axis in epileptic mice: A novel regulator of synaptic plasticity involving STAT3 signaling.
Topics: Animals; Antagomirs; Epilepsy; Mice; MicroRNAs; Neuronal Plasticity; Pentylenetetrazole; Seizures; S | 2022 |
Pentylenetetrazole-induced seizures cause impairment of memory acquisition and consolidation in zebrafish (Danio rerio).
Topics: Animals; Anticonvulsants; Epilepsy; Memory; Pentylenetetrazole; Seizures; Zebrafish | 2022 |
Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio).
Topics: Animals; Anticonvulsants; Caspase 3; Diazepam; Epilepsy; Interleukin-1beta; Neuroprotective Agents; | 2022 |
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenet | 2022 |
Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy-The Effects of Treatment with a GPR39 Agonist and Knockout of the
Topics: Animals; Disease Models, Animal; Epilepsy; Magnesium; Mice; Mice, Knockout; Pentylenetetrazole; Rece | 2022 |
Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria.
Topics: Animals; Disease Models, Animal; GAP-43 Protein; Mice; Neocortex; Pentylenetetrazole; Polymicrogyria | 2022 |
Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice.
Topics: Animals; Anticonvulsants; Chloroquine; Disease Models, Animal; Electroshock; Mefloquine; Mice; Naltr | 2022 |
Proanthocyanidins alleviate pentylenetetrazole-induced epileptic seizures in mice via the antioxidant activity.
Topics: Animals; Anticonvulsants; Antioxidants; Epilepsy; Mice; NF-E2-Related Factor 2; Oxidative Stress; Pe | 2022 |
Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes.
Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Anima | 2022 |
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanos | 2022 |
Ferulic acid inhibits catamenial epilepsy through modulation of female hormones.
Topics: Adult; Animals; Corticosterone; Epilepsy; Estradiol; Female; Finasteride; Horses; Humans; Mice; Neur | 2022 |
Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice.
Topics: Animals; Benzodiazepines; Cannabinoid Receptor Agonists; Cannabinoids; Convulsants; Diazepam; Electr | 2022 |
Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Inflammation; Interleukin-10; Neuroinfla | 2022 |
Morin offsets PTZ-induced neuronal degeneration and cognitive decrements in rats: The modulation of TNF-α/TNFR-1/RIPK1,3/MLKL/PGAM5/Drp-1, IL-6/JAK2/STAT3/GFAP and Keap-1/Nrf-2/HO-1 trajectories.
Topics: Animals; Cognition; Epilepsy; Flavonoids; Hippocampus; Interleukin-6; Janus Kinase 2; Kindling, Neur | 2022 |
The Anti-Seizure Effect of Liraglutide on Ptz-Induced Convulsions Through its Anti-Oxidant and Anti-Inflammatory Properties.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; | 2023 |
Targeting firing rate neuronal homeostasis can prevent seizures.
Topics: Animals; Anticonvulsants; Benzaldehydes; Drosophila; Homeostasis; Mice; Neurons; Pentylenetetrazole; | 2022 |
Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation.
Topics: Animals; Benzoquinones; Epilepsy; Ferroptosis; Glutathione; Heptanoic Acids; Mice; Pentylenetetrazol | 2022 |
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Epilepsy; Heptanoic Acids; Lanoster | 2022 |
Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Capsaicin; Diazepam; Endocannabinoids; Mice; Pentylenetetrazole; Polyunsat | 2022 |
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway.
Topics: Animals; Brain Injuries; Caspase 3; Dimethyl Sulfoxide; Epilepsy; Hippocampus; Kindling, Neurologic; | 2023 |
Glial cells inhibition affects the incidence of metaplasticity in the hippocampus of Pentylentetrazole-induced kindled rats.
Topics: Animals; Astrocytes; Hippocampus; Incidence; Kindling, Neurologic; Neuronal Plasticity; Pentylenetet | 2022 |
DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-Actions in a Pentylenetetrazole-Induced Kindling Model in Mice.
Topics: Animals; Depression; Docosahexaenoic Acids; Eicosapentaenoic Acid; Ferroptosis; Mice; Neuroinflammat | 2022 |
Cannabidiol effect in pentylenetetrazole-induced seizures depends on PI3K.
Topics: Animals; Anticonvulsants; Cannabidiol; Mice; Pentylenetetrazole; Phosphatidylinositol 3-Kinase; Phos | 2022 |
Decreased Spire2 Expression is Involved in Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; | 2022 |
Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; Exercise; | 2022 |
Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; bcl-2-Associated X Protein; Benzamides; Disease Mo | 2022 |
Novel spiro[indene-1,2'-quinazolin]-4'(3'H)-one derivatives as potent anticonvulsant agents: One-pot synthesis, in vivo biological evaluation, and molecular docking studies.
Topics: Anticonvulsants; Binding Sites; Humans; Molecular Docking Simulation; Pentylenetetrazole; Receptors, | 2023 |
Stem bark chloroform extract of Bombax costatum Pellegr. & Vuillet exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Bombax; Chloroform; gamma-Aminobutyric Acid; Neuroprotective Agents; Penty | 2023 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model.
Topics: 4-Butyrolactone; Animals; Autophagy; Cognition; Disease Models, Animal; Epilepsy; Hippocampus; Kindl | 2022 |
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats.
Topics: Animals; Anticonvulsants; Caffeine; Diazepam; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Ra | 2022 |
Downregulatory effect of miR-342-3p on epileptogenesis in the PTZ-kindling model.
Topics: Animals; Down-Regulation; Hippocampus; Male; MicroRNAs; Pentylenetetrazole; Rats; Rats, Wistar; Seiz | 2022 |
Pentylenetetrazol-induced seizures are followed by a reduction in the multiunitary activity of hippocampal CA1 pyramidal neurons in adult rats.
Topics: Action Potentials; Animals; Hippocampus; Male; Pentylenetetrazole; Pyramidal Cells; Rats; Seizures | 2022 |
Effects of Hyssopus Officinalis Hydroalcoholic Extract on Pentylenetetrazol-Induced Convulsive Seizures in Rat.
Topics: Animals; Anticonvulsants; Antioxidants; Flumazenil; Hyssopus Plant; Kindling, Neurologic; Nitric Oxi | 2022 |
Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents.
Topics: Anticonvulsants; Electroshock; Humans; Molecular Docking Simulation; Molecular Structure; Pentylenet | 2022 |
Overexpression of Homer1b/c induces valproic acid resistance in epilepsy.
Topics: Animals; Anticonvulsants; Epilepsy; Mice; Pentylenetetrazole; Rats; Receptor, Metabotropic Glutamate | 2023 |
Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats.
Topics: Animals; Dizocilpine Maleate; Hippocampus; Neuronal Plasticity; Pentylenetetrazole; Rats; Receptors, | 2022 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ivermectin; Mice | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures.
Topics: Animals; Anticonvulsants; Cognition; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Pentyl | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.
Topics: Animals; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; NF-kappa B; Pentylenetetrazole; RNA, Ci | 2022 |
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.
Topics: Animals; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; NF-kappa B; Pentylenetetrazole; RNA, Ci | 2022 |
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.
Topics: Animals; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; NF-kappa B; Pentylenetetrazole; RNA, Ci | 2022 |
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.
Topics: Animals; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; NF-kappa B; Pentylenetetrazole; RNA, Ci | 2022 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Topics: Anethum graveolens; Animals; Anticonvulsants; Antioxidants; Epilepsy; Pentylenetetrazole; Picrotoxin | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep | 2023 |
Chronic stress but not acute stress decreases the seizure threshold in PTZ-induced seizure in mice: role of inflammatory response and oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Male; Mice; Oxidative Stress; | 2023 |
Tonic and phasic stimulations of ventral tegmental area have opposite effects on pentylenetetrazol kindled seizures in mice.
Topics: Anticonvulsants; Humans; Kindling, Neurologic; Pentylenetetrazole; Seizures; Ventral Tegmental Area | 2023 |
Antibiotics modulate frequency and early generation of epileptic seizures in zebrafish.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Seizures; Zebr | 2023 |
Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy.
Topics: Animals; Electroshock; Epilepsy; Mice; Pentylenetetrazole; Receptors, G-Protein-Coupled; Seizures; Z | 2023 |
The opposite effect of convulsant drugs on neuronal and endothelial nitric oxide synthase - A possible explanation for the dual proconvulsive/anticonvulsive action of nitric oxide.
Topics: Anticonvulsants; Convulsants; Enzyme Inhibitors; Humans; Neurons; Nitric Oxide; Nitric Oxide Synthas | 2023 |
The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish.
Topics: Adenosine; Animals; Dipyridamole; Epilepsy; Pentylenetetrazole; Quality of Life; Seizures; Valproic | 2023 |
Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Male; Mice; Mice, Inbred Strains; NL | 2023 |
Exploring the mechanism of Chaihujia Longgu Muli decoction in the treatment of epilepsy in rats based on the RhoA/ROCK signaling pathway.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; rho-Associated K | 2023 |
Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats.
Topics: Animals; Anticonvulsants; Brain; Dinoprost; Disease Models, Animal; Epilepsy; Humans; Immunosuppress | 2023 |
Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers.
Topics: Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Cognition; Epilepsy; Kindling, Neurolog | 2023 |
Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Male; Mice; Oleanolic Acid; Pentylenetetrazole; Seizu | 2023 |
Comprehensive characterization of amino acids and water-soluble vitamins in a pentylenetetrazole-induced seizures rat model.
Topics: Amino Acids; Animals; Epilepsy; Pentylenetetrazole; Rats; Seizures; Vitamins; Water | 2023 |
Neuroprotective effects of Royal Jelly (RJ) against pentylenetetrazole (PTZ)-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; Inflammation; Male; Neurop | 2023 |
The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis.
Topics: Animals; Anticonvulsants; Cannabidiol; Epilepsy; Mice; Multiomics; Pentylenetetrazole; Seizures | 2023 |
Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Seizures; Valproic Acid | 2023 |
Medial prefrontal cortex oxytocin mitigates epilepsy and cognitive impairments induced by traumatic brain injury through reducing neuroinflammation in mice.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; | 2023 |
Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; Epilepsy; Lamotri | 2023 |
Nicorandil Exerts Anticonvulsant Effects in Pentylenetetrazol-Induced Seizures and Maximal-Electroshock-Induced Seizures by Downregulating Excitability in Hippocampal Pyramidal Neurons.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Hippocampus; | 2023 |
Tetramethylpyrazine contributes to the neuroprotection in a rodent epileptic model of pentylenetetrazole-induced kindling.
Topics: Animals; Epilepsy; Hippocampus; Kindling, Neurologic; Neuroinflammatory Diseases; Neuroprotection; P | 2023 |
Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures.
Topics: Animals; Anticonvulsants; Epilepsy; Larva; Pentylenetetrazole; Seizures; Zebrafish | 2023 |
Antiseizure Properties of Histamine H
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Histamine; Histamine H3 Antagonists; Hum | 2023 |
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions.
Topics: Acetylcysteine; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy; | 2023 |
The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Topics: Animals; Apelin; Endocytosis; Kainic Acid; Mice; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate | 2023 |
Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment.
Topics: AMP-Activated Protein Kinases; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relat | 2023 |
Effect of Rosiglitazone, the Peroxisome Proliferator-Activated Receptor (PPAR)-γ Agonist, on Apoptosis, Inflammatory Cytokines and Oxidative Stress in pentylenetetrazole-Induced Seizures in Kindled Mice.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Cytokines; Interleukin-10; Interleukin-6; Kindlin | 2023 |
Pharmacognostic profiles, evaluation of analgesic, anti-inflammatory and anticonvulsant activities of Newbouldia laevis (P. Beauv.) Seem. ex Bureau leaf and root extracts in Wistar rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Edema; Inflammation; Methanol; Penty | 2023 |
Ceftriaxone and selenium mitigate seizures and neuronal injury in pentylenetetrazole-kindled rats: Oxidative stress and inflammatory pathway.
Topics: Animals; Anticonvulsants; Antioxidants; Ceftriaxone; Epilepsy; Glutamates; Neurotransmitter Agents; | 2023 |
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures.
Topics: Animals; Anterior Thalamic Nuclei; Epilepsy, Absence; Mice; Neurons; Parvalbumins; Pentylenetetrazol | 2023 |
Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation.
Topics: Acetylcholine; Animals; Anticonvulsants; Choline; Humans; Pentylenetetrazole; Seizures; Serotonin; T | 2023 |
Neuroprotective effect of Berberine Nanoparticles Against Seizures in Pentylenetetrazole Induced Kindling Model of Epileptogenesis: Role of Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Berberine; Kindling, Neurologic; Male; Neuroprot | 2023 |
Supplementation of n-3 PUFAs in Adulthood Attenuated Susceptibility to Pentylenetetrazol Induced Epilepsy in Mice Fed with n-3 PUFAs Deficient Diet in Early Life.
Topics: Animals; Diet; Dietary Supplements; Docosahexaenoic Acids; Epilepsy; Fatty Acids, Omega-3; Female; M | 2023 |
Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems.
Topics: Albizzia; Amnesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Epilepsy; gamma | 2023 |
Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies.
Topics: Animals; Anticonvulsants; Antioxidants; Chloroform; Epilepsy; Gallic Acid; gamma-Aminobutyric Acid; | 2023 |
The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties.
Topics: Alchemilla; Animals; Anticonvulsants; Antioxidants; Catalase; Epilepsy; Female; gamma-Aminobutyric A | 2023 |
Delayed treatment with ceftriaxone reverses the enhanced sensitivity of TBI mice to chemically-induced seizures.
Topics: Animals; Brain Injuries, Traumatic; Ceftriaxone; Disease Models, Animal; Epilepsy, Post-Traumatic; G | 2023 |
Effects of probiotics on GABA/glutamate and oxidative stress in PTZ- induced acute seizure model in rats.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Male; Oxidative Stress; | 2023 |
Neuroprotective anticonvulsant and anxiolytic effects of octreotide in wistar rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Male; Mice; Neuroprotective Agents; Octreot | 2023 |
Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway.
Topics: Acorus; Animals; Anticonvulsants; Anxiety; Epilepsy; gamma-Aminobutyric Acid; Inflammation; Mice; Ox | 2023 |
Seizure-induced increase in microglial cell population in the developing zebrafish brain.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Microglia; Pentylenetetrazole; Seizur | 2023 |
Optimization of the Zebrafish Larvae Pentylenetetrazol-Induced Seizure Model for the Study of Caffeine and Topiramate Interactions.
Topics: Animals; Caffeine; Chromatography, Liquid; Larva; Pentylenetetrazole; Seizures; Tandem Mass Spectrom | 2023 |
In Silico Analysis, Anticonvulsant Activity, and Toxicity Evaluation of Schisandrin B in Zebrafish Larvae and Mice.
Topics: Animals; Anticonvulsants; Glutamic Acid; Larva; Mice; Molecular Docking Simulation; Pentylenetetrazo | 2023 |
(-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Inflammation; Male; Memory Disorders; Ne | 2023 |
A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.
Topics: Animals; Child; Cognition; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Hum | 2023 |
Acute and Sub-chronic Anticonvulsant Effects of Edaravone on Seizure Induced by Pentylenetetrazole or Electroshock in Mice, Nitric Oxide Involvement.
Topics: Animals; Anticonvulsants; Edaravone; Electroshock; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine M | 2023 |
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish.
Topics: Acetylcarnitine; Acetylcysteine; Adult; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; | 2023 |
Can endoplasmic reticulum stress observed in the PTZ-kindling model seizures be prevented with TUDCA and 4-PBA?
Topics: Animals; Endoplasmic Reticulum Stress; Epilepsy; Kindling, Neurologic; Oxidative Stress; Pentylenete | 2023 |
Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice.
Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Epilepsy; Humans; Mice; Oxidative Stress; Pentylenet | 2023 |
Mechanochemical synthesis and anticonvulsant activity of 3-aminopyrrolidine-2,5-dione derivatives.
Topics: Animals; Anticonvulsants; Ethosuximide; Humans; Mice; Molecular Structure; Neuroblastoma; Pentylenet | 2023 |
Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Brain; Brain-Gut Axis; Epilepsy; Gastrointestinal M | 2023 |
Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility.
Topics: Animals; Anticonvulsants; Diazepam; Humans; Male; Pentylenetetrazole; Phenobarbital; Phosphodiestera | 2023 |
Ferulic acid ameliorates pentylenetetrazol-induced seizures by reducing neuron cell death.
Topics: Animals; Antioxidants; Apoptosis; Convulsants; Coumaric Acids; Malondialdehyde; Memory; Neurons; Neu | 2019 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Anima | 2020 |
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide | 2020 |
Propionate relieves pentylenetetrazol-induced seizures, consequent mitochondrial disruption, neuron necrosis and neurological deficits in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosine Triphosphate; Animals; Catalase; Exploratory Behavior; Female | 2019 |
Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogs.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Di | 2019 |
Involvement of peroxisome proliferator-activated receptor γ in anticonvulsant activity of α-asaronol against pentylenetetrazole-induced seizures in zebrafish.
Topics: Allylbenzene Derivatives; Anilides; Animals; Anisoles; Anticonvulsants; Behavior, Animal; Convulsant | 2020 |
5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Bacterial Agents; Cefepime; Convulsants; Disease Models, Animal; Fluorouracil; Kindlin | 2019 |
Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress.
Topics: Animals; Anticonvulsants; Apoptosis; Cinnamates; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Re | 2019 |
Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats.
Topics: Acetophenones; Animals; Anticonvulsants; Antioxidants; Apoptosis; Epilepsy; Hippocampus; Lipid Perox | 2019 |
Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Epilepsy; Female; Male; Pentylenetet | 2020 |
The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings.
Topics: Animals; Brain; Caffeine; Calcium Channels, T-Type; Epilepsy, Absence; Female; Male; Pentylenetetraz | 2019 |
Modeling psychiatric comorbid symptoms of epileptic seizures in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Female; GABA Antagonists; Humans; Locomo | 2019 |
Evaluation of the anticonvulsant effect of novel melatonin derivatives in the intravenous pentylenetetrazol seizure test in mice.
Topics: Administration, Intravenous; Animals; Anticonvulsants; Drug Interactions; Male; Melatonin; Mice; Mol | 2019 |
Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Brain; Cognition; Epilepsy; Insulin; Kainic Ac | 2020 |
Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Chromones; Class I Phosphatidylinositol 3-Kinases | 2019 |
Neuropharmacological effects of d-pinitol and its possible mechanisms of action.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Flumazenil; Hypnotics and Seda | 2019 |
Urokinase receptor and tissue plasminogen activator as immediate-early genes in pentylenetetrazole-induced seizures in the mouse brain.
Topics: Animals; Brain; Genes, Immediate-Early; Mice; Pentylenetetrazole; Receptors, Urokinase Plasminogen A | 2020 |
Oestrogen receptor ERα and ERβ agonists ameliorate oxidative brain injury and improve memory dysfunction in rats with an epileptic seizure.
Topics: Animals; Avoidance Learning; Brain Injuries; Estrogen Receptor alpha; Estrogen Receptor beta; Male; | 2019 |
Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Convulsants; Disease Models, Animal; Ghrelin; | 2019 |
Activation of adenosine receptors modulates the efflux transporters in brain capillaries and restores the anticonvulsant effect of carbamazepine in carbamazepine resistant rats developed by window-pentylenetetrazole kindling.
Topics: Animals; Anticonvulsants; Brain; Capillaries; Carbamazepine; Disease Models, Animal; Drug Resistant | 2020 |
Novel effect of Arthrocen (avocado/soy unsaponifiables) on pentylenetetrazole-induced seizure threshold in mice: Role of GABAergic pathway.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; GABAergic Neurons; Glycine max; Male; Mi | 2020 |
Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Epilepsies, Myoclonic; Mice; Mon | 2019 |
Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration.
Topics: Animals; Convulsants; Female; Genetic Background; Interpersonal Relations; Kainic Acid; Male; Memory | 2019 |
Neuroprotective Dihydro-β-agarofuran-Type Sesquiterpenes from the Seeds of
Topics: Amyloid beta-Peptides; Animals; Cell Line; Cell Survival; Convulsants; Euonymus; Humans; Locomotion; | 2019 |
Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Maze Learning; Oxidative Stress; Pentyle | 2019 |
An interaction study of Ocimum sanctum L. and levetiracetam in pentylenetetrazole kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Avoidance Learning; Disease Models, Animal; Drug Therapy, Combination; Epi | 2020 |
Synthesis and Evaluation of N-substituted (Z)-5-(Benzo[d][1,3]dioxol-5- ylmethylene)-2-Thioxothiazolidin-4-one Derivatives and 5-Substituted- Thioxothiazolidindione Derivatives as Potent Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Mice; Molecular Docking Si | 2019 |
Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice.
Topics: Acetylcholinesterase; Animals; Anxiety; Brain; Isoenzymes; Male; Maze Learning; Mice; Mice, Inbred B | 2020 |
Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
Topics: Animals; Anticonvulsants; Anxiety; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channe | 2019 |
Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Mice, Inbred | 2020 |
Micronized resveratrol shows promising effects in a seizure model in zebrafish and signalizes an important advance in epilepsy treatment.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Pentylenetetrazole; Resveratrol; Seizures; Treatme | 2020 |
Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists.
Topics: Animals; Brain; Bridged-Ring Compounds; Drug Evaluation, Preclinical; GABA-A Receptor Antagonists; P | 2020 |
Screening of Some Novel 4, 5 Disubstituted 1, 2, 4-Triazole-3-thiones for Anticonvulsant Activity.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Ataxia; Convulsants; Drug Evaluation, Precli | 2020 |
Design and synthesis of novel parabanic acid derivatives as anticonvulsants.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Hepatocytes; Hydantoins; Ma | 2020 |
Selective Blockade of Neuronal BK (α + β4) Channels Preventing Epileptic Seizure.
Topics: Animals; Anticonvulsants; GABA-A Receptor Antagonists; Humans; Large-Conductance Calcium-Activated P | 2020 |
Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats.
Topics: Animals; Anticonvulsants; Convulsants; Gene Expression Regulation; Hippocampus; Kindling, Neurologic | 2020 |
Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Berberine; Female; Macrophages; Male; Pentylenet | 2020 |
Garlic passion fruit (Passiflora tenuifila Killip): Assessment of eventual acute toxicity, anxiolytic, sedative, and anticonvulsant effects using in vivo assays.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Dia | 2020 |
Effects of erythropoietin pretreatment on single dose pentylentetrazole-induced seizures in rats.
Topics: Animals; Disease Models, Animal; Erythropoietin; Hippocampus; Male; Memory; Neurons; Neuroprotective | 2020 |
Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABA
Topics: Animals; Anticonvulsants; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats.
Topics: Animals; Cognition; Dietary Supplements; Excitatory Postsynaptic Potentials; Hippocampus; Kindling, | 2020 |
Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures.
Topics: Animals; Anticonvulsants; Brain; Capsaicin; Dose-Response Relationship, Drug; Lipid Peroxidation; Ma | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; D | 2020 |
Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole.
Topics: Animals; Anticonvulsants; Betahistine; Hippocampus; Kindling, Neurologic; Male; Memory Disorders; Mi | 2020 |
Inhibition of NMDA Receptors Downregulates Astrocytic AQP4 to Suppress Seizures.
Topics: Animals; Aquaporin 4; Astrocytes; Brain; Pentylenetetrazole; Rats, Sprague-Dawley; Receptors, N-Meth | 2020 |
The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of epilepsy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Epilepsy; Genetic Predisposition to Disease; Male; Penty | 2020 |
Salvinorin A Does Not Affect Seizure Threshold in Mice.
Topics: Animals; Diterpenes, Clerodane; Drug Evaluation, Preclinical; Electroshock; Injections, Intravenous; | 2020 |
Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide.
Topics: Acetamides; Animals; Anticonvulsants; Disopyramide; Dose-Response Relationship, Drug; Electroshock; | 2020 |
Design, synthesis and docking studies of novel benzopyrone derivatives as anticonvulsants.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Electroshock; Injections, S | 2020 |
Rongchang and Xifeng capsules suppress pentylenetetrazole-induced seizures and change rest/wake behavior in zebrafish larvae.
Topics: Animals; Anticonvulsants; Drugs, Chinese Herbal; Larva; Male; Pentylenetetrazole; Rest; Seizures; Wa | 2019 |
Potential anticonvulsant activity of novel VV-hemorphin-7 analogues containing unnatural amino acids: synthesis and characterization.
Topics: Amino Acids, Cyclic; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Hemoglobins; Mice; Molec | 2020 |
Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Female; Injections, Subcut | 2020 |
Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice.
Topics: Animals; Anticonvulsants; Dextromethorphan; Dose-Response Relationship, Drug; Male; Mice; Pentylenet | 2020 |
Transcranial photobiomodulation attenuates pentylenetetrazole-induced status epilepticus in peripubertal rats.
Topics: Animals; Hippocampus; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2020 |
Full-Spectrum
Topics: Animals; Anticonvulsants; Cannabidiol; Cannabis; Delayed-Action Preparations; Drug Liberation; Mice; | 2020 |
Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Topics: Animals; Anticonvulsants; Diclofenac; Epilepsy; Kindling, Neurologic; Male; Meloxicam; Mice; Pentyle | 2020 |
Glaucacetalin E and galphimidin B from Galphimia glauca and their anxiolytic activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Disease Models, Animal; Ex | 2020 |
The Influence of Palmatine Isolated from
Topics: Animals; Behavior, Animal; Berberine; Berberine Alkaloids; Berberis; Blood-Brain Barrier; Brain-Deri | 2020 |
Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Respons | 2020 |
Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; Disease Models, An | 2020 |
MS275 reduces seizure-induced brain damage in developing rats by regulating p38 MAPK signaling pathways and epigenetic modification.
Topics: Animals; Convulsants; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Male; MAP Kinase Signalin | 2020 |
Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Inflammation; Kindling, Neurologic; Male; Pe | 2020 |
Cannabis constituents reduce seizure behavior in chemically-induced and scn1a-mutant zebrafish.
Topics: Acyclic Monoterpenes; Animals; Animals, Genetically Modified; Anticonvulsants; Cannabidiol; Cannabin | 2020 |
Neuropolybin: A new antiseizure peptide obtained from wasp venom.
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy; Female; Male; Mice; Pentylenetetrazole; | 2020 |
Intracerebroventricular administration of N-type calcium channel blocker ziconotide displays anticonvulsant, anxiolytic, and sedative effects in rats: A preclinical and pilot study.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Calcium Channel Blockers; Calcium Channels, N-Type; D | 2020 |
The possible role of nitric oxide in anti-convulsant effects of Naltrindole in seizure-induced by social isolation stress in male mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Male; Mice; Naltrexone; Narcotic Anta | 2020 |
Recording of spontaneous vagus nerve activity during Pentylenetetrazol-induced seizures in rats.
Topics: Animals; Pentylenetetrazole; Rats; Reproducibility of Results; Seizures; Vagus Nerve; Vagus Nerve St | 2020 |
Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats.
Topics: Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopep | 2020 |
Mice Lacking Connective Tissue Growth Factor in the Forebrain Exhibit Delayed Seizure Response, Reduced C-Fos Expression and Different Microglial Phenotype Following Acute PTZ Injection.
Topics: Animals; Astrocytes; Cell Count; Claustrum; Connective Tissue Growth Factor; Convulsants; Gene Expre | 2020 |
Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Electroencephalography; Mice, Inbred C57BL; Mice | 2020 |
Contribution of excess inflammation to a possible rat model of eclamptic reversible posterior leukoencephalopathy syndrome induced by lipopolysaccharide and pentylenetetrazol: A preliminary study.
Topics: Animals; Astrocytes; Blood Pressure; Blood-Brain Barrier; Brain; Disease Models, Animal; Eclampsia; | 2020 |
Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion.
Topics: Animals; Anticonvulsants; Dinoprost; Ibuprofen; Male; Myoclonus; Pentylenetetrazole; Rats, Sprague-D | 2020 |
The anticonvulsant effect of sparteine on pentylenetetrazole-induced seizures in rats: a behavioral, electroencephalographic, morphological and molecular study.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biomarkers; Brain; Disease Management; Disease Models, A | 2020 |
Interaction of morphine tolerance with pentylenetetrazole-induced seizure threshold in mice: The role of NMDA-receptor/NO pathway.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Mice; Morphine; N-Methylaspartate; NG-Ni | 2020 |
Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole.
Topics: Animals; Inflammasomes; Kindling, Neurologic; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; P | 2021 |
Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity.
Topics: 3' Untranslated Regions; Animals; Axons; Cells, Cultured; Convulsants; Dependovirus; Disease Models, | 2020 |
Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Amides; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; | 2020 |
Metabolic Alterations Predispose to Seizure Development in High-Fat Diet-Treated Mice: the Role of Metformin.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Blood Glucose; Body Composition; Depression; | 2020 |
[Regulatory mechanism of MS275 on the p38 MAPK signaling pathway in rats with convulsion in the developmental stage].
Topics: Animals; Male; p38 Mitogen-Activated Protein Kinases; Pentylenetetrazole; Rats; Rats, Sprague-Dawley | 2020 |
Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents.
Topics: Animals; Anticonvulsants; Kindling, Neurologic; Pentylenetetrazole; Seizures; Zebrafish | 2020 |
Enantiomeric N-substituted phthalimides with excitatory amino acids protect zebrafish larvae against PTZ-induced seizures.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acids; Larva; Neuroprot | 2020 |
Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Computer Simulation; Disease Models, Animal; Electroencephalography; Ethos | 2021 |
Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain; Gene Knockout Techniques; Male; Mice; Mice, In | 2020 |
Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cytoskeletal Proteins; Epilepsy; Ergothion | 2020 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy | 2020 |
Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility.
Topics: Animals; Electroshock; GABA-A Receptor Antagonists; Mice; Neurons; Pentylenetetrazole; Peptide Chain | 2020 |
Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature-dependent seizures.
Topics: Animals; Animals, Newborn; Body Temperature; Cells, Cultured; Extracellular Fluid; gamma-Aminobutyri | 2021 |
The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Brain; Brain-Derived Neurotrophic Fac | 2021 |
Anti-convulsant Action and Attenuation of Oxidative Stress by Citrus limon Peel Extracts in PTZ and MES Induced Convulsion in Albino Rats.
Topics: Animals; Citrus; Oxidative Stress; Pentylenetetrazole; Plant Extracts; Rats; Seizures | 2020 |
Increased Seizure Susceptibility for Rats Subject to Early Life Hypoxia Might Be Associated with Brain Dysfunction of NRG1-ErbB4 Signaling in Parvalbumin Interneurons.
Topics: Animals; Animals, Newborn; Brain; Cell Count; Disease Susceptibility; Female; Gene Expression Regula | 2020 |
Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Anticonvulsants; Apoptosis; Cholinergic Agents; Hipp | 2020 |
Synthesis, anticonvulsant, and antinociceptive activity of new 3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)propanamides and 3-phenyl-butanamides.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pain | 2021 |
Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Cerebellum; Diazepam; Electric Stimulation; Kindling, Neurologic | 2020 |
Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Chemistry; Convulsants; Curcuma; Flumazenil; GABA Modu | 2020 |
Trehalose Ameliorates Seizure Susceptibility in Lafora Disease Mouse Models by Suppressing Neuroinflammation and Endoplasmic Reticulum Stress.
Topics: Animals; Autophagy; Brain; Calcium-Binding Proteins; Disease Models, Animal; Disease Susceptibility; | 2021 |
Micronized Resveratrol Shows Anticonvulsant Properties in Pentylenetetrazole-Induced Seizure Model in Adult Zebrafish.
Topics: Animals; Anticonvulsants; Diazepam; Female; Locomotion; Male; Particle Size; Pentylenetetrazole; Pro | 2021 |
Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Humans; Hydrazin | 2021 |
The effects of salmon calcitonin on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole-induced epilepsy model in rats.
Topics: Animals; Calcitonin; Epilepsy; Hippocampus; Kindling, Neurologic; Pentylenetetrazole; Rats; Seizures | 2020 |
Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest.
Topics: Acoustic Stimulation; Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals | 2021 |
Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug.
Topics: Animals; Anticonvulsants; Biological Transport; Blood-Brain Barrier; Esters; Hydrophobic and Hydroph | 2021 |
Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish.
Topics: Animals; Anxiety; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of pentylenetetrazole-induced acute seizure.
Topics: Animals; Diet, Ketogenic; Disease Models, Animal; Gastrointestinal Microbiome; Limosilactobacillus f | 2021 |
D-limonene Inhibits Pentylenetetrazole-Induced Seizure via Adenosine A2A Receptor Modulation on GABAergic Neuronal Activity.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Convulsants; Disease Models, Animal; GABAergi | 2020 |
Perampanel exhibits anticonvulsant action against pentylentetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Nitriles; Pentylenetetrazole; Pyridones; Rats; Rats, Wistar; Seizures | 2021 |
iTRAQ-based proteomic analysis of the hippocampus of pentylenetetrazole-kindled epileptic rats.
Topics: Animals; Chromatography, Liquid; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazo | 2021 |
Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures.
Topics: Anticonvulsants; Cicuta; Humans; Kindling, Neurologic; Oxidative Stress; Pentylenetetrazole; Seizure | 2021 |
Effects of prednisolone on behavioral and inflammatory profile in animal model of PTZ-induced seizure.
Topics: Animals; Anti-Inflammatory Agents; Brain; Inflammation Mediators; Locomotion; Male; Pentylenetetrazo | 2021 |
The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Dietary Supplements; Humans; Lycopene; Male; Nitric Oxide; Pentylenetetraz | 2021 |
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures.
Topics: Animals; Anisoles; Bicuculline; Convulsants; Gene Expression; Genetic Predisposition to Disease; Hab | 2021 |
LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroencephalography; GABA-A Receptor Ant | 2021 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction | 2021 |
Effect of Memantine on Pentylenetetrazol-induced Seizures and EEG Profile in Animal Model of Cortical Malformation.
Topics: Animals; Disease Models, Animal; Electroencephalography; Male; Memantine; Pentylenetetrazole; Rats; | 2021 |
Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Male; Me | 2021 |
Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relation | 2021 |
FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation.
Topics: Aging; Animals; Animals, Newborn; Cognitive Dysfunction; Epilepsy; Female; Fingolimod Hydrochloride; | 2021 |
Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Central Nervo | 2021 |
Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Dihydrotestosterone; Disease Models, | 2021 |
Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of Naphthoquinone Derivatives Containing Pyrazole and Pyrimidine Fragments.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Antidepressive Agents; Depression; Male; Mice; N | 2020 |
Fenofibrate protects the neurovascular unit and ameliorates plasma corticosterone levels in pentylenetetrazole-induced kindling seizure in mice.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Brain-Derived Neurotrophic Factor; Convulsants | 2021 |
In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dose-Response Re | 2021 |
Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice.
Topics: Animals; Anxiety; Convulsants; Creatine; Depression; Dose-Response Relationship, Drug; Glutathione; | 2021 |
Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats.
Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Electroencephalography; Epilepsy, Absen | 2021 |
Mast cell activation ameliorates pentylenetetrazole-induced seizures in rats: The potential role for serotonin.
Topics: Animals; Anticonvulsants; Cromolyn Sodium; Epilepsy; Male; Mast Cells; Pentylenetetrazole; Rats; Rat | 2022 |
The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Docosahexaenoic Acids; Fat | 2021 |
In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Pentylenetetrazole; Pilocarp | 2020 |
Antiseizure potential of peptides from the venom of social wasp Chartergellus communis against chemically-induced seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Pentylenetetrazole; Peptides; Seizures; Wasp Venom | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mi | 2021 |
A hydrogen sulfide donor suppresses pentylenetetrazol-induced seizures in rats via PKC signaling.
Topics: Animals; Anticonvulsants; Aquaporin 4; Brain Waves; Cytokines; Disease Models, Animal; Hippocampus; | 2021 |
Anti-Seizure Activity of 1-Adamantane Carboxylic Acid in Common Experimental Seizure Models: Role of Benzodiazepine-GABAA Receptors.
Topics: Adamantane; Amygdala; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Electroshoc | 2021 |
Nedd4-2 haploinsufficiency in mice causes increased seizure susceptibility and impaired Kir4.1 ubiquitination.
Topics: Animals; Convulsants; Endosomal Sorting Complexes Required for Transport; Haploinsufficiency; Male; | 2021 |
Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway.
Topics: Animals; Convulsants; Gene Expression Regulation; Hypoglycemic Agents; Insulin; Male; Mice; Mitochon | 2021 |
The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line.
Topics: Animals; Anticonvulsants; Antioxidants; Apoptosis; Brain; Caspase 3; Cell Line; Disease Models, Anim | 2021 |
Pharmacological Activity of Pyrazole Derivatives as an Anticonvulsant for Benefit against Epilepsy.
Topics: Animals; Anticonvulsants; Child; Disease Models, Animal; Epilepsy; Humans; Mice; Pentylenetetrazole; | 2021 |
Effects of the Calcium Channel Blocker Otilonium Bromide on Seizure Activity in Rats With Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Electroencephalography; Male; Malondialdehyde; P | 2021 |
Increased Excitatory Synaptic Transmission Associated with Adult Seizure Vulnerability Induced by Early-Life Inflammation in Mice.
Topics: Animals; Convulsants; Excitatory Postsynaptic Potentials; Female; Hippocampus; Inflammation; Lipopol | 2021 |
Single step nanospray drying preparation technique of gabapentin-loaded nanoparticles-mediated brain delivery for effective treatment of PTZ-induced seizures.
Topics: Animals; Brain; Chitosan; Drug Carriers; Gabapentin; Nanoparticles; Particle Size; Pentylenetetrazol | 2021 |
Examination of the antiepileptic effects of valacyclovir using kindling mice- search for novel antiepileptic agents by drug repositioning using a large medical information database.
Topics: Animals; Anticonvulsants; Cefepime; Databases, Factual; Disease Models, Animal; Drug Repositioning; | 2021 |
Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Brain Chemistry; Catalase; Cymbopogon; Disease Model | 2021 |
Gamma-Decanolactone Alters the Expression of GluN2B, A
Topics: Animals; Body Weight; Cyclooxygenase 2; DNA Damage; Female; Lactones; Male; Mice; Neuroprotective Ag | 2021 |
Neuroprotective effect of both synbiotics and ketogenic diet in a pentylenetetrazol-induced acute seizure murine model.
Topics: Animals; Diet, Ketogenic; Disease Models, Animal; Mice; Neuroprotective Agents; Pentylenetetrazole; | 2021 |
Vagus Nerve Electroneurogram-Based Detection of Acute Pentylenetetrazol Induced Seizures in Rats.
Topics: Animals; Epilepsy; Pentylenetetrazole; Rats; Seizures; Treatment Outcome; Vagus Nerve; Vagus Nerve S | 2021 |
Alterations in mRNA and Protein Expression of Glutamate Receptor Subunits Following Pentylenetetrazole-induced Acute Seizures in Young Rats.
Topics: Animals; Hippocampus; Pentylenetetrazole; Rats; Receptors, AMPA; Receptors, Glutamate; RNA, Messenge | 2021 |
Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress.
Topics: Animals; Apoptosis; Glycosides; Inflammation; Oxidative Stress; Pentylenetetrazole; Seizures; Zebraf | 2021 |
Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Melatonin; Mice; Oxidative Stress; Pentylene | 2021 |
Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats.
Topics: Animals; Brain; Disease Models, Animal; Kindling, Neurologic; Male; Memory; Memory Disorders; Neuron | 2021 |
Succinate accumulation contributes to oxidative stress and iron accumulation in pentylenetetrazol-induced epileptogenesis and kainic acid-induced seizure.
Topics: Animals; Cerebral Cortex; Hippocampus; Iron; Kainic Acid; Male; Malonates; Oxidative Stress; Pentyle | 2021 |
A zebrafish-centric approach to antiepileptic drug development.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Seizures; Zebrafish | 2021 |
Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
Topics: Animals; Death-Associated Protein Kinases; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, | 2021 |
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Humans; Mechanistic Targe | 2022 |
Modulation of PTZ-induced convulsions in rats using topiramate alone or combined with low dose gamma irradiation: involving AKT/m-TOR pathway.
Topics: Animals; Anticonvulsants; Male; Oxidative Stress; Pentylenetetrazole; Proto-Oncogene Proteins c-akt; | 2022 |
Effects of probiotics on pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Diazepam; Mice; Pentylenetetrazole; Probiotics; Seizures | 2021 |
Investigation on the Anticonvulsant Potential of Luteolin and Micronized Luteolin in Adult Zebrafish (Danio rerio).
Topics: Age Factors; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Luteolin; Male; Par | 2021 |
Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Dose-Response Relationship, Dru | 2021 |
Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Convulsants; Cytokines; Disease Models, Animal; Epile | 2021 |
Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyr | 2021 |
Survival analysis of nonperiodic stimulation (NPS) performance.
Topics: Animals; Anticonvulsants; Drug Resistant Epilepsy; Pentylenetetrazole; Rats; Seizures; Survival Anal | 2021 |
Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biological Availability; Curcumin; Disease Models, Anima | 2021 |
Micellar buccal film for safe and effective control of seizures: Preparation, in vitro characterization, ex vivo permeation studies and in vivo assessment.
Topics: Animals; Anticonvulsants; Humans; Lamotrigine; Micelles; Pentylenetetrazole; Rats; Seizures | 2021 |
Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the
Topics: Animals; Antioxidants; Cyclohexane Monoterpenes; Epilepsy; Kindling, Neurologic; Lipid Peroxidation; | 2021 |
Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice.
Topics: Acute Disease; Animals; Brain; Ellagic Acid; Male; Mice; Motor Activity; Muscle Strength; Pentylenet | 2021 |
Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures.
Topics: Animals; CD40 Antigens; CD40 Ligand; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lob | 2021 |
Early preclinical evaluation of dihydropyrimidin(thi)ones as potential anticonvulsant drug candidates.
Topics: Animals; Anticonvulsants; Cell Line; Cell Line, Tumor; Cell Survival; Electroshock; Humans; Male; Mi | 2017 |
Loss of Cannabinoid CB1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility.
Topics: Animals; Cell Movement; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Electropora | 2017 |
The activity of selective sigma-1 receptor ligands in seizure models in vivo.
Topics: Acetamides; Analysis of Variance; Animals; Anisoles; Anticonvulsants; Bicuculline; Convulsants; Male | 2017 |
Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism.
Topics: Animals; Anticonvulsants; Brain; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Lamiaceae; Medicin | 2017 |
Transplantation of inhibitory precursor cells from medial ganglionic eminence produces distinct responses in two different models of acute seizure induction.
Topics: Acute Disease; Animals; Disease Models, Animal; Electroshock; Female; Hippocampus; Interneurons; Mal | 2017 |
Genistein modulation of seizure: involvement of estrogen and serotonin receptors.
Topics: Animals; Anticonvulsants; Biguanides; Dose-Response Relationship, Drug; Fabaceae; Female; Genistein; | 2017 |
Pattern recognition analysis of proton nuclear magnetic resonance spectra of postmortem cerebrospinal fluid from rats with drug-induced seizure or coma.
Topics: Animals; Cerebrospinal Fluid; Coma; Convulsants; Discriminant Analysis; Hypnotics and Sedatives; Mag | 2017 |
Anticonvulsant activity of Caryocar coriaceum Wittm. fixed pulp oil against pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Convulsants; Electroencephalography; Ericales; Male; Mice; Mice, Inbred C5 | 2017 |
[ANTISEIZURE ACTIVITY OF C EPHALARIA GIGANTEA ROOT EXTRACT].
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dipsacaceae; Female; Hypnotics and Sedatives; Male; | 2017 |
HPLC-Based Activity Profiling for GABA
Topics: Animals; Blood-Brain Barrier; Molecular Structure; Pentylenetetrazole; Plant Extracts; Plant Roots; | 2017 |
Posterior hypothalamus glutamate infusion decreases pentylenetetrazol-induced seizures of male rats through hippocampal histamine increase.
Topics: Animals; Glutamic Acid; Histamine Release; Hypothalamus; Male; Pentylenetetrazole; Rats; Rats, Wista | 2017 |
The role of nitric oxide in anticonvulsant effect of nanocurcumine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Convulsants; Curcumin; Dose-Response Relationship, Drug; Indazoles; Male; | 2017 |
Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2
Topics: Age Factors; Animals; Body Temperature; Convulsants; Disease Models, Animal; Electroencephalography; | 2017 |
The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space.
Topics: Animals; Convulsants; Disease Models, Animal; Dopaminergic Neurons; Epilepsy; Hippocampus; Kindling, | 2017 |
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Frag | 2017 |
Justicia spicigera Schltdl. and kaempferitrin as potential anticonvulsant natural products.
Topics: Animals; Anticonvulsants; Biological Products; Dose-Response Relationship, Drug; Injections, Intrave | 2017 |
The influence of temperature on adult zebrafish sensitivity to pentylenetetrazole.
Topics: Animals; Anticonvulsants; Body Weight; Convulsants; Dizocilpine Maleate; Female; Fever; Male; Models | 2017 |
Anticonvulsive activity of (1S)-(-)-verbenone involving RNA expression of BDNF, COX-2, and c-fos.
Topics: Animals; Anticonvulsants; Bicyclic Monoterpenes; Brain-Derived Neurotrophic Factor; Cyclooxygenase 2 | 2017 |
Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy.
Topics: Animals; Automation, Laboratory; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; La | 2017 |
Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine.
Topics: Acetamides; Animals; Anticonvulsants; Antioxidants; Depression; Drug Therapy, Combination; Epilepsy; | 2017 |
Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokine levels in the cerebral cortex and hippocampus of mice.
Topics: Animals; Cerebral Cortex; Cyclooxygenase 2 Inhibitors; Cytokines; Hippocampus; Inflammation; Male; M | 2017 |
Traumatic brain injury causes long-term behavioral changes related to region-specific increases of cerebral blood flow.
Topics: Animals; Brain Injuries, Traumatic; Cerebrovascular Circulation; Conditioning, Psychological; Diseas | 2017 |
Optical mapping of neuronal activity during seizures in zebrafish.
Topics: Animals; Biomarkers; Brain; Calcium; Disease Models, Animal; High-Throughput Screening Assays; Molec | 2017 |
A New Rat Model of Seizures Suitable for Screening Antiepileptic Electrical Stimulation Therapies.
Topics: Animals; Convulsants; Disease Models, Animal; Electric Stimulation Therapy; Electrocorticography; El | 2018 |
Assessing the role of serotonergic receptors in cannabidiol's anticonvulsant efficacy.
Topics: Animals; Anticonvulsants; Cannabidiol; Fluorobenzenes; Male; Pentylenetetrazole; Piperazines; Piperi | 2017 |
Replicable in vivo physiological and behavioral phenotypes of the
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Biomarkers; Convulsants; Disease Models, Anim | 2017 |
EP2 receptor agonist ONO-AE1-259-01 attenuates pentylenetetrazole- and pilocarpine-induced seizures but causes hippocampal neurotoxicity.
Topics: Animals; Anticonvulsants; Dinoprostone; Hippocampus; Male; Mice; Neurons; Neurotoxicity Syndromes; P | 2017 |
Effect of the Leaf Essential Oil from Cinnamosma madagascariensis Danguy on Pentylenetetrazol-induced Seizure in Rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Magnoliopsida; Male; Oils, Volat | 2017 |
Evaluation of the Anticonvulsant Effect of Brilliant Blue G, a Selective P2X7 Receptor Antagonist, in the iv PTZ-, Maximal Electroshock-, and 6 Hz-Induced Seizure Tests in Mice.
Topics: Animals; Anticonvulsants; Benzenesulfonates; Dose-Response Relationship, Drug; Drug Evaluation, Prec | 2017 |
Intranasal nerve growth factor attenuating the seizure onset via p75R/Caspase pathway in the experimental epilepsy.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Brain; Caspase 3; Epilepsy; Male; Nerve Growth | 2017 |
HBK-14 and HBK-15, triple 5-HT
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Disease Models, Animal; Electr | 2017 |
Effect of lamotrigine on seizure development in a rat pentylenetetrazole kindling model.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Kindling, Neurologic; Lamotrigin | 2017 |
(+)-Dehydrofukinone modulates membrane potential and delays seizure onset by GABAa receptor-mediated mechanism in mice.
Topics: Animals; Anticonvulsants; Female; Flumazenil; GABA Modulators; Membrane Potentials; Mice; Pentylenet | 2017 |
Selective Silencing of Hippocampal Parvalbumin Interneurons Induces Development of Recurrent Spontaneous Limbic Seizures in Mice.
Topics: Animals; Electroencephalography; Hippocampus; Inhibitory Postsynaptic Potentials; Interneurons; Male | 2017 |
Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid.
Topics: Animals; Aromatase Inhibitors; Brain; Cerebral Cortex; Dietary Supplements; Docosahexaenoic Acids; E | 2017 |
Neuropharmacological and neuroprotective activities of some metabolites produced by cell suspension culture of Waltheria americana Linn.
Topics: Animals; Anticonvulsants; Biomass; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glial Fibrillar | 2017 |
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilep | 2019 |
Evidence for the involvement of the GABA-ergic pathway in the anticonvulsant activity of the roots bark aqueous extract of Anthocleista djalonensis A. Chev. (Loganiaceae).
Topics: Animals; Anticonvulsants; Benzodiazepines; gamma-Aminobutyric Acid; Loganiaceae; Male; Mice; Mice, I | 2017 |
The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model.
Topics: Adenosine; Animals; Brain; Caffeine; Central Nervous System Stimulants; Convulsants; Cytokines; Dise | 2017 |
Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cytokines; Disease Models, Animal; Disease Sus | 2017 |
A species dependent response to the pro-epileptic drug pentylentetrazole in birds.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Immu | 2017 |
Design, synthesis and evaluation of newer 5,6-dihydropyrimidine-2(1H)-thiones as GABA-AT inhibitors for anticonvulsant potential.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Desig | 2017 |
Trigeminal nerve stimulation induces Fos immunoreactivity in selected brain regions, increases hippocampal cell proliferation and reduces seizure severity in rats.
Topics: Amygdala; Animals; Cell Proliferation; Epilepsy; Hippocampus; Male; Pentylenetetrazole; Proto-Oncoge | 2017 |
Hybrid photoacoustic and electrophysiological recording of neurovascular communications in freely-moving rats.
Topics: Animals; Capillaries; Convulsants; Disease Models, Animal; Electrodes, Implanted; Hemodynamics; Male | 2017 |
Circadian variation in anticonvulsant activity of valproic acid in mice.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Drug Administration Schedule; Male; Mice; Pentylenetetra | 2017 |
Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia.
Topics: Acetamides; Animals; Anticonvulsants; Electroencephalography; Female; GABA Antagonists; Lacosamide; | 2017 |
Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition; Disease Models, Animal; Drug | 2017 |
Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress.
Topics: Animals; Endoplasmic Reticulum Stress; Hippocampus; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2017 |
Manual acupuncture improves parameters associated with oxidative stress and inflammation in PTZ-induced kindling in mice.
Topics: Acupuncture Therapy; Animals; Anticonvulsants; Antioxidants; Convulsants; Disease Models, Animal; In | 2017 |
Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques.
Topics: Alzheimer Disease; Animals; Benzylamines; Cerebral Cortex; Disease Models, Animal; Disease Susceptib | 2017 |
Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Electric Stimulation; Flumazenil; Male; Mice; Pe | 2018 |
Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Cytochromes c; Diet, Ketogenic; Epilepsy; Hippoca | 2018 |
Effects of genistein on pentylenetetrazole-induced behavioral and neurochemical deficits in ovariectomized rats.
Topics: Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Female; Genistein; Neuroprotectiv | 2018 |
The anticonvulsant activity and cerebral protection of chronic lithium chloride via NMDA receptor/nitric oxide and phospho-ERK.
Topics: Animals; Anticonvulsants; Cells, Cultured; Cerebellum; Cerebral Cortex; Disease Models, Animal; Dizo | 2018 |
Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Brain; Calcitonin; Drug Synergism; gamma-Aminobutyric Acid; Mi | 2018 |
CD36 Deficiency Suppresses Epileptic Seizures.
Topics: Action Potentials; Analysis of Variance; Animals; CD36 Antigens; Convulsants; Disease Models, Animal | 2017 |
Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Ethanol; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2018 |
Sub-chronic boldine treatment exerts anticonvulsant effects in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Aporphines; Ascorbic Acid; Brain; Disease Models, Animal; Do | 2018 |
Modulation of the anticonvulsant effect of swim stress by agmatine.
Topics: Agmatine; Analgesics, Opioid; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Respo | 2018 |
Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Excitator | 2018 |
The effect of vitamin U on the lung tissue of pentyleneterazole-induced seizures in rats.
Topics: Animals; Lipid Peroxidation; Lung; Male; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Sprague-D | 2018 |
Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq.
Topics: Animals; Cell Nucleus; Centrifugation, Density Gradient; Cerebral Cortex; Disease Models, Animal; Hi | 2017 |
Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cyclooxygenase Inh | 2018 |
Protective effect of Terminalia chebula against seizures, seizure-induced cognitive impairment and oxidative stress in experimental models of seizures in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzothiazoles; Biphenyl Compounds; Cognitive Dysfunctio | 2018 |
Altered expression of GABA-A receptor subunits in the hippocampus of PTZ-kindled rats.
Topics: Animals; Brain Waves; Disease Models, Animal; GABA Plasma Membrane Transport Proteins; Hippocampus; | 2018 |
Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1.
Topics: Animals; Brain; Cyclooxygenase 2; Disease Models, Animal; Gene Expression; Male; Mice, Inbred C57BL; | 2018 |
A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Disease Models, Animal; Drug Delivery Syste | 2018 |
Embryonic exposure to ethanol increases the susceptibility of larval zebrafish to chemically induced seizures.
Topics: Animals; Convulsants; Disease Models, Animal; Embryo, Nonmammalian; Epilepsy; Ethanol; Larva; Pentyl | 2018 |
Biphasic effect of sumatriptan on PTZ-induced seizures in mice: Modulation by 5-HT1B/D receptors and NOS/NO pathway.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Nitric Oxide; N | 2018 |
Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish.
Topics: Animals; Benzyl Alcohols; Convulsants; Disease Progression; Dose-Response Relationship, Drug; Glucos | 2018 |
Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Convulsants; Disease Models, Animal; Dose-Respo | 2018 |
Behavioral and electroencephalographic evaluation of the anticonvulsive activity of Moringa oleifera leaf non-polar extracts and one metabolite in PTZ-induced seizures.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroencephalography; Ethanol; Hexanes; Ma | 2018 |
Endophilin A1 mediates seizure activity via regulation of AMPARs in a PTZ-kindled epileptic mouse model.
Topics: Acyltransferases; Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hum | 2018 |
The anticonvulsant effect of a polysaccharide-rich extract from Genipa americana leaves is mediated by GABA receptor.
Topics: Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Hippocampus; Mice; Neuroprotective Agents; | 2018 |
Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Disease Models, Animal; Endocannabinoids; Glycerides; M | 2018 |
Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; M | 2018 |
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice, Inbred C57 | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Resp | 2018 |
Design, synthesis, in vivo and in silico evaluation of phenacyl triazole hydrazones as new anticonvulsant agents.
Topics: Animals; Anticonvulsants; Biological Availability; Drug Design; Hydrazones; Injections, Intraperiton | 2018 |
Anticonvulsant effect of minocycline on pentylenetetrazole-induced seizure in mice: involvement of nitric oxide and N-methyl-d-aspartate receptor.
Topics: Animals; Anticonvulsants; Arginine; Enzyme Inhibitors; Hippocampus; Male; Mice; Minocycline; Nitric | 2018 |
Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation.
Topics: Animals; Anticonvulsants; Benzene Derivatives; Carbonic Anhydrase Inhibitors; Convulsants; Dose-Resp | 2018 |
Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats.
Topics: Adipokines; Animals; Brain Waves; Carrier Proteins; Convulsants; Cytokines; Disease Models, Animal; | 2018 |
Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase-2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro and in-vivo evaluation.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Epilepsy; Huma | 2018 |
Elevation of MMP-9 Levels Promotes Epileptogenesis After Traumatic Brain Injury.
Topics: Animals; Brain Injuries, Traumatic; Cerebral Cortex; Epilepsy, Post-Traumatic; Genotype; Male; Matri | 2018 |
Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi.
Topics: Animals; Anticonvulsants; Chemical Fractionation; Diatoms; Disease Models, Animal; Inosine; Magnetic | 2018 |
Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor.
Topics: Animals; Bridged-Ring Compounds; Disease Models, Animal; Imidazoles; Larva; Mice; Mice, Inbred C57BL | 2018 |
Corilagin Reduces the Frequency of Seizures and Improves Cognitive Function in a Rat Model of Chronic Epilepsy.
Topics: Animals; Biomarkers; Brain; Carbonic Anhydrases; Catalase; Cell Count; Chronic Disease; Cognition; C | 2018 |
Clarified Açaí (
Topics: Animals; Anticonvulsants; Cells, Cultured; Complex Mixtures; Diazepam; Disease Models, Animal; Euter | 2018 |
Taurine Protects from Pentylenetetrazole-Induced Behavioral and Neurochemical Changes in Zebrafish.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Brain Chemistry; Cell Death; Cell Survival; Diazepam | 2019 |
Satb2 ablation decreases PTZ-induced seizure susceptibility and pyramidal neuronal excitability.
Topics: Animals; Epilepsy; Hippocampus; Matrix Attachment Region Binding Proteins; Mice, Transgenic; Pentyle | 2018 |
NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation.
Topics: Animals; Cells, Cultured; Drug Delivery Systems; Enzyme Inhibitors; Inflammation; Lipopolysaccharide | 2018 |
Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception.
Topics: Analgesia; Animals; Ibotenic Acid; Male; Microinjections; Pain Measurement; Pedunculopontine Tegment | 2018 |
2, 5-Disubstituted Phthalimides: Design, Synthesis and Anticonvulsant Activity in scPTZ and MES Models.
Topics: Animals; Anticonvulsants; Drug Design; Electroshock; Male; Mice; Molecular Docking Simulation; Penty | 2018 |
Semaphorin 4D promotes inhibitory synapse formation and suppresses seizures in vivo.
Topics: Animals; Animals, Newborn; Anticonvulsants; Antigens, CD; Cells, Cultured; Convulsants; Disease Mode | 2018 |
Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy.
Topics: Animals; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice; Neurons; Neuroprotective Agents; O | 2018 |
A role for peroxisome proliferator-activated receptor α in anticonvulsant activity of docosahexaenoic acid against seizures induced by pentylenetetrazole.
Topics: Animals; Anticonvulsants; Docosahexaenoic Acids; Injections, Intraventricular; Male; Mice; Oxazoles; | 2018 |
[Establish and use of an epilepsy model in larval zebrafish].
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Larva; Nerve Tissue Proteins; Pen | 2016 |
Overexpression of miRNA-137 in the brain suppresses seizure activity and neuronal excitability: A new potential therapeutic strategy for epilepsy.
Topics: Adolescent; Adult; Animals; Brain; Disease Models, Animal; Epilepsy; Female; Humans; Inhibitory Post | 2018 |
Selective Blockade of T-Type Ca2+ Channels is Protective Against Alcohol-Withdrawal Induced Seizure and Mortality.
Topics: Alcohol Withdrawal Seizures; Animals; Benzamides; Calcium Channel Blockers; Calcium Channels, T-Type | 2018 |
Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.
Topics: Administration, Inhalation; Albuterol; Animals; Atropine; Bronchodilator Agents; Convulsants; Diazep | 2018 |
Transient Morphological Alterations in the Hippocampus After Pentylenetetrazole-Induced Seizures in Rats.
Topics: Animals; Antigens, Nuclear; Caspase 3; Cell Death; Cell Survival; Excitatory Amino Acid Transporter | 2018 |
[PATHOLOGICAL CHANGES DEVELOPMENT IN THE HEART WITH UNDERLYING CONVULSIVE SYNDROME MODEL OF VARIOUS ETIOLOGIES.]
Topics: Adenosine Triphosphate; Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; L-Lact | 2016 |
Pentylenetetrazole-Induced Kindling Mouse Model.
Topics: Animals; Brain; Disease Models, Animal; GABA Antagonists; Injections, Intraperitoneal; Kindling, Neu | 2018 |
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.
Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heter | 2018 |
Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways.
Topics: alpha-Tocopherol; Animals; Anticonvulsants; Antioxidants; Brain; Inflammation; Male; Neurons; Neurop | 2018 |
Asynchronous, bilateral, and biphasic temporally unstructured electrical stimulation of amygdalae enhances the suppression of pentylenetetrazole-induced seizures in rats.
Topics: Amygdala; Animals; Cortical Synchronization; Deep Brain Stimulation; Disease Models, Animal; Drug Re | 2018 |
Acute Boldine Treatment Induces Anti-convulsant Effects in Mice through its Antioxidant Activity.
Topics: Animals; Anticonvulsants; Antioxidants; Aporphines; Ascorbic Acid; Brain; Disease Models, Animal; Do | 2019 |
Neuroanatomical Localization of Galanin in Zebrafish Telencephalon and Anticonvulsant Effect of Galanin Overexpression.
Topics: Animals; Animals, Genetically Modified; Convulsants; Galanin; Heat-Shock Response; HSP70 Heat-Shock | 2018 |
Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Calcium-Binding Proteins; Disease Models, Animal; DNA-B | 2018 |
Effects of Modafinil on Clonic Seizure Threshold Induced by Pentylenetetrazole in Mice: Involvement of Glutamate, Nitric oxide, GABA, and Serotonin Pathways.
Topics: Animals; Anticonvulsants; Enzyme Inhibitors; Glutamic Acid; Indazoles; Male; Mice; Modafinil; NG-Nit | 2018 |
The effect of high-fat diet on seizure threshold in rats: Role of oxidative stress.
Topics: Animals; Cerebellum; Cerebral Cortex; Diet, High-Fat; Disease Models, Animal; Epilepsy; Hippocampus; | 2018 |
Acute foot-shock stress decreased seizure susceptibility against pentylenetetrazole-induced seizures in mice: Interaction between endogenous opioids and cannabinoids.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Antagonists; Convulsants; Disease Models, Animal; | 2018 |
A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.
Topics: Animals; Anticonvulsants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Convulsants; Dise | 2018 |
Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Encephalitis; Epilepsy; G | 2018 |
[COMPARISON OF CHRONIC ANTICONVULSANT ACTIVITY AND SAFETY OF IEM-2062, SODIUM VALPROATE AND ME-MANTINE IN THE PENTYLENETETRAZOL KINDLING MODEL IN RATS].
Topics: Administration, Oral; Animals; Anticonvulsants; Convulsants; Cyclohexanes; Cyclohexylamines; Drug Ad | 2017 |
Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Cognitive Dysfunction; Convulsants; Hydroxyme | 2018 |
Comparative study of alpha- and beta-pinene effect on PTZ-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Bicyclic Monoterpenes; Brain; Bridged Bicyclo Compounds; Disease Models, A | 2019 |
The role of serotonin and its receptors on the anticonvulsant effect of curcumin in pentylenetetrazol-induced seizures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Convulsants; Curcumin; Drug Combi | 2018 |
KA-11, a Novel Pyrrolidine-2,5-dione Derived Broad-Spectrum Anticonvulsant: Its Antiepileptogenic, Antinociceptive Properties and in Vitro Characterization.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Molecular Struct | 2019 |
Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2.
Topics: Animals; Catalase; Convulsants; Diet, Ketogenic; Disease Models, Animal; Enzyme Inhibitors; Gene Exp | 2018 |
Convulsive seizures and EEG spikes after lateral fluid-percussion injury in the rat.
Topics: Animals; Brain Injuries; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; E | 2018 |
Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model.
Topics: Animals; Brain; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Gluta | 2019 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pen | 2018 |
Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Mice; Mice, | 2018 |
Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway.
Topics: Animals; Anticonvulsants; Convulsants; Gamma Rays; Gene Expression Regulation; Male; Pentylenetetraz | 2018 |
Effect of aliskiren, a direct renin inhibitor, on the protective action of antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice.
Topics: Amides; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Anima | 2019 |
Deep brain stimulation probing performance is enhanced by pairing stimulus with epileptic seizure.
Topics: Amygdala; Animals; Convulsants; Deep Brain Stimulation; Disease Models, Animal; Electroencephalograp | 2018 |
Single pentylenetetrazole exposure increases aggression in adult zebrafish at different time intervals.
Topics: Aggression; Animals; Behavior, Animal; Disease Models, Animal; Female; GABA Antagonists; Male; Penty | 2019 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
Naringin in a combined therapy with phenytoin on pentylenetetrazole-induced kindling in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Drug Therapy, Combination; Flavanones; Hippocampus; Kindling | 2018 |
Synthesis, molecular modeling studies, and anticonvulsant evaluation of novel 1-((2-hydroxyethyl)(aryl)amino)-N-substituted cycloalkanecarboxamides and their acetate esters.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru | 2018 |
Pycnogenol Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Mice.
Topics: Animals; Anticonvulsants; Antioxidants; Convulsants; Flavonoids; Mice; Oxidative Stress; Pentylenete | 2019 |
Flavonoids isolated from Tibetan medicines, binding to GABA
Topics: Animals; Anticonvulsants; Arenaria Plant; Asteraceae; China; Flavonoids; Flunitrazepam; GABA-A Recep | 2018 |
Effect of dimethyl fumarate on neuroinflammation and apoptosis in pentylenetetrazol kindling model in rats.
Topics: Animals; Apoptosis; Dimethyl Fumarate; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; | 2019 |
Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy.
Topics: Animals; Antigens, Nuclear; Arbutin; Astrocytes; Cognitive Dysfunction; Cytokines; Disease Models, A | 2019 |
High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.
Topics: Animals; Animals, Genetically Modified; Brain; Brain Mapping; Convulsants; Disease Models, Animal; D | 2018 |
Ivabradine possesses anticonvulsant and neuroprotective action in mice.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Ivabradine; Male; Mice; Neuroprot | 2019 |
Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model.
Topics: Animals; Anticonvulsants; Butyrates; Glycosides; Ipomoea nil; Pentylenetetrazole; Plant Extracts; Re | 2019 |
Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Caspase 3; Convul | 2019 |
Synthesis, characterization and anticonvulsant activity of new azobenzene-containing VV-hemorphin-5 bio photoswitch.
Topics: Animals; Anticonvulsants; Azo Compounds; Electric Capacitance; Electrochemistry; Hemoglobins; Light; | 2019 |
Transient Switching of NMDA-Dependent Long-Term Synaptic Potentiation in CA3-CA1 Hippocampal Synapses to mGluR
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Excitatory Postsynaptic Potentials; Long- | 2019 |
The Possible Role of Nitric Oxide Pathway in Pentylenetetrazole Preconditioning Against Seizure in Mice.
Topics: Animals; Brain; Enzyme Inhibitors; GABA Antagonists; Guanidines; Indazoles; Male; Mice; NG-Nitroargi | 2019 |
A novel oxazolidinone derivative PH192 demonstrates anticonvulsant activity in vivo in rats and mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Oxazolidinones; Pentylenetet | 2019 |
Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats.
Topics: Animals; Anticonvulsants; Drug Therapy, Combination; Enalapril; Heart Diseases; Kindling, Neurologic | 2019 |
Anticonvulsant evaluation and docking analysis of VV-Hemorphin-5 analogues.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Electroshock; Hemoglobins; Male; Mice, Inbred ICR; Mo | 2019 |
Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, | 2019 |
Effects of High- and Low-Frequency Stimulation of the Thalamic Reticular Nucleus on Pentylentetrazole-Induced Seizures in Rats.
Topics: Animals; Deep Brain Stimulation; Male; Pentylenetetrazole; Random Allocation; Rats; Rats, Wistar; Se | 2019 |
Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats.
Topics: Animals; Brain Injuries, Traumatic; Brain Waves; CA3 Region, Hippocampal; Cell Death; Creatine; Epil | 2019 |
The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Apiaceae; Bicyclic Monoterpenes; Catalase; Chromatography, H | 2019 |
Repulsive guidance molecule a suppresses seizures and mossy fiber sprouting via the FAK‑p120RasGAP‑Ras signaling pathway.
Topics: Animals; Disease Models, Animal; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; GPI-Linke | 2019 |
Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility.
Topics: Animals; Anxiety; Avoidance Learning; Brain Waves; Convulsants; Disease Models, Animal; Disease Susc | 2019 |
Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model.
Topics: Acetylcholine; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Cognitive Dysfunc | 2019 |
Persistent alterations in seizure susceptibility, drug responsiveness and comorbidities associated with chemical kindling after neonatal exposure to an organophosphate.
Topics: Affect; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Chlorpyrifos; Cholinest | 2019 |
Effect of Pterostilbene, a Natural Analog of Resveratrol, on the Activity of some Antiepileptic Drugs in the Acute Seizure Tests in Mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; Electrosho | 2019 |
The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy.
Topics: Animals; Biomarkers; Brain Chemistry; Convulsants; Disease Susceptibility; Glial Fibrillary Acidic P | 2019 |
Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Guanidines; Indazoles; Ketamine; Male; Methadone; Mic | 2019 |
Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva.
Topics: alpha-Linolenic Acid; Animals; Behavior, Animal; Convulsants; Dietary Supplements; Disease Models, A | 2019 |
Four N-(E)-cinnamoyl (cinnamamide) derivatives of aminoalkanols with promising anticonvulsant and analgesic activity.
Topics: Amino Alcohols; Analgesics; Animals; Anticonvulsants; Cinnamates; Dose-Response Relationship, Drug; | 2019 |
Vitamin E modifies high-fat diet-induced reduction of seizure threshold in rats: Role of oxidative stress.
Topics: Animals; Antioxidants; Biomarkers; Brain; Catalase; Diet, High-Fat; Disease Models, Animal; Glutathi | 2019 |
Evidence for the involvement of a GABAergic mechanism in the effectiveness of natural and synthetically modified incensole derivatives in neuropharmacological disorders: A computational and pharmacological approach.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biological Products; Diterpenes; Maze Learning; Mi | 2019 |
Immunohistochemical Study of Antioxidant Enzymes Regulated by Nrf2 in the Models of Epileptic Seizures (KA and PTZ).
Topics: Animals; Antioxidants; Behavior, Animal; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Model | 2019 |
Effect of probiotic supplementation on seizure activity and cognitive performance in PTZ-induced chemical kindling.
Topics: Animals; Biomarkers; Brain; Cognition; Convulsants; Gastrointestinal Microbiome; Kindling, Neurologi | 2019 |
PTZ-induced seizures in mice require a revised Racine scale.
Topics: Animals; Convulsants; Disease Models, Animal; Electroencephalography; Female; Male; Mice; Mice, Inbr | 2019 |
Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Convulsants; Disease Models, Animal; D | 2019 |
Interaction of sigma-1 receptor modulators with seizure development in pentylenetetrazole-induced kindled mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Convulsants; Kindling, Neurologic; Male; Mice; Mice, Inbred B | 2019 |
Evaluation of anticonvulsant and antiepileptogenic activity of Euphorbia nivulia in PTZ-induced kindling model of epilepsy in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Euphorbia; | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Binding Sites; Cinnamates; Drug Design; Epil | 2019 |
Anticonvulsant and anti-apoptosis effects of salvianolic acid B on pentylenetetrazole-kindled rats via AKT/CREB/BDNF signaling.
Topics: Animals; Anticonvulsants; Apoptosis; Benzofurans; Brain-Derived Neurotrophic Factor; Cyclic AMP Resp | 2019 |
Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures.
Topics: Animals; Anticonvulsants; Cannabidiol; Cannabinoids; Disease Models, Animal; Male; Pentylenetetrazol | 2019 |
Seizure suppression by asynchronous non-periodic electrical stimulation of the amygdala is partially mediated by indirect desynchronization from nucleus accumbens.
Topics: Action Potentials; Amygdala; Animals; Deep Brain Stimulation; Electroencephalography; Male; Nucleus | 2019 |
Sema7A, a brain immune regulator, regulates seizure activity in PTZ-kindled epileptic rats.
Topics: Adolescent; Adult; Animals; Antigens, CD; Child; Child, Preschool; Convulsants; Dentate Gyrus; Epile | 2020 |
Antiepileptic Effects of Protein-Rich Extract from
Topics: Animals; Anticonvulsants; Antioxidants; Apoptosis; Bombyx; Cell Survival; Convulsants; Electroshock; | 2019 |
Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium.
Topics: Animals; Anticonvulsants; Chlorides; Glutamic Acid; Lithium Chloride; Male; Mice; Neuroprotective Ag | 2019 |
Synthesis and Pharmacological Evaluation of 3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile Derivatives as Orally Active AMPA Receptor Antagonists.
Topics: Administration, Oral; Animals; Anticonvulsants; Hippocampus; Locomotion; Male; Mice; Mice, Inbred IC | 2019 |
Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Disease Models, Animal; gamma-Aminobu | 2018 |
Spatial exploration induced expression of immediate early genes Fos and Zif268 in adult-born neurons Is reduced after pentylenetetrazole kindling.
Topics: Animals; Bromodeoxyuridine; Convulsants; Doublecortin Protein; Early Growth Response Protein 1; Expl | 2019 |
The effect of exercise on GABA signaling pathway in the model of chemically induced seizures.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression; Glutamate Decarboxylase; | 2019 |
The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kaini | 2019 |
Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Pentylenetetrazole; Physical Conditioning, A | 2019 |
GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy.
Topics: Animals; Anticonvulsants; Benzoates; Body Temperature Regulation; Cerebral Cortex; Diazepam; Epileps | 2013 |
Anticonvulsant effect of Berberis integerrima L. root extracts in mice.
Topics: Animals; Anticonvulsants; Berberis; Humans; Male; Mice; Pentylenetetrazole; Plant Extracts; Plant Ro | 2013 |
Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7.
Topics: Animals; Brain; Brain Ischemia; Convulsants; Disease Models, Animal; Electroencephalography; Epileps | 2013 |
[The effect of ionotropic glutamate receptor antagonist on pentylenetetrazole-indused seizures in Krushinsky-Molodkina rats].
Topics: Animals; Anticonvulsants; Cyclohexylamines; Epilepsy, Reflex; Excitatory Amino Acid Antagonists; Fem | 2012 |
Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Curcumin; Depr | 2013 |
Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish.
Topics: Action Potentials; Administration, Oral; Amines; Analysis of Variance; Animals; Anticonvulsants; Bra | 2013 |
MRI biomarkers for post-traumatic epileptogenesis.
Topics: Animals; Area Under Curve; Biomarkers; Brain Injuries; Brain Mapping; Convulsants; Diffusion Tensor | 2013 |
Down-regulation of RalBP1 expression reduces seizure threshold and synaptic inhibition in mice.
Topics: Animals; Brain; CA1 Region, Hippocampal; GTPase-Activating Proteins; In Vitro Techniques; Injections | 2013 |
Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rats.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Caffeine; Central Nervous System Stimulants; Convulsa | 2013 |
Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome.
Topics: Animals; Behavior, Animal; Circadian Rhythm; Cognition; Disease Models, Animal; Down Syndrome; Elect | 2013 |
The threshold of pentylenetetrazole-induced convulsive seizures, but not that of nonconvulsive seizures, is controlled by the nitric oxide levels in murine brains.
Topics: Analysis of Variance; Animals; Brain; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2013 |
Contribution of estradiol in sex-dependent differences of pentylenetetrazole-induced seizures in rats.
Topics: Animals; Estradiol; Female; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Sex Characterist | 2013 |
P-glycoprotein contributes to cell membrane depolarization of hippocampus and neocortex in a model of repetitive seizures induced by pentylenetetrazole in rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Hippocampus; Huma | 2013 |
Treadmill exercise protects against pentylenetetrazol-induced seizures and oxidative stress after traumatic brain injury.
Topics: Animals; Brain; Brain Chemistry; Brain Injuries; Convulsants; Electrodes, Implanted; Electroencephal | 2013 |
Effect of different frequencies of repetitive transcranial magnetic stimulation on acquisition of chemical kindled seizures in rats.
Topics: Animals; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Transcranial | 2013 |
BDNF-TrkB signaling pathway is involved in pentylenetetrazole-evoked progression of epileptiform activity in hippocampal neurons in anesthetized rats.
Topics: Administration, Intravenous; Anesthesia, General; Animals; Brain-Derived Neurotrophic Factor; CA1 Re | 2013 |
Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; GABA Uptake Inhib | 2013 |
Anticonvulsant effect of the essential oil and methanolic extracts of Zataria multiflora Boiss.
Topics: Animals; Anticonvulsants; Distillation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinic | 2013 |
Anticonvulsant activity of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose isolated from leaves of Mangifera indica.
Topics: Animals; Anticonvulsants; Brain; Electroshock; gamma-Aminobutyric Acid; Hydrolyzable Tannins; Male; | 2013 |
Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; gamma-Aminobu | 2012 |
[Effects of heterotherapy for homopathy on the metabolism path of glutamate in the pentylenetetrazol-kindled seizure rats' hippocampus].
Topics: Animals; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Kindling, Neurologic; Male | 2013 |
Pentylenetetrazol-induced seizures are associated with Na⁺,K⁺-ATPase activity decrease and alpha subunit phosphorylation state in the mice cerebral cortex.
Topics: Animals; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Mal | 2013 |
Anti-epileptogenic and antioxidant effect of Lavandula officinalis aerial part extract against pentylenetetrazol-induced kindling in male mice.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Kindling, Neurologic; Lavandula; Male; Malondialdehyd | 2013 |
Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse.
Topics: Adaptation, Ocular; Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Fear | 2013 |
Comparison between standard protocol and a novel window protocol for induction of pentylenetetrazol kindled seizures in the rat.
Topics: Animals; Behavior, Animal; Convulsants; Electrodes, Implanted; Electroencephalography; Excitatory Po | 2013 |
The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2013 |
The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cannabidiol; Convulsants; Disease Models, Animal; Do | 2013 |
Role of nitric oxide in additive anticonvulsant effects of agmatine and morphine.
Topics: Agmatine; Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Enzyme | 2013 |
Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Female; Humans; | 2013 |
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.
Topics: Animals; Anticonvulsants; Calcium Signaling; Dose-Response Relationship, Drug; Drug Evaluation, Prec | 2013 |
The role of α₂-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoids; Clonidine; Dose-Response Relationship, Dr | 2013 |
Seizure protection by intrapulmonary delivery of midazolam in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Routes; Kainic Acid; | 2013 |
The long-term effects of neonatal morphine administration on the pentylenetetrazol seizure model in rats: the role of hippocampal cholinergic receptors in adulthood.
Topics: Analgesics, Opioid; Animals; Hippocampus; Male; Morphine; Pentylenetetrazole; Rats; Rats, Wistar; Re | 2014 |
Effects of intrahippocampal injection of ghrelin on spatial memory in PTZ-induced seizures in male rats.
Topics: Animals; Convulsants; Disease Models, Animal; Ghrelin; Hippocampus; Injections; Male; Maze Learning; | 2013 |
Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures.
Topics: Acetamides; Animals; Brain; Catalase; Female; Lipid Peroxidation; Mice; Nitrites; Oxidative Stress; | 2013 |
Design and synthesis of some 3-substituted-2-[(2,4-dichlorophenoxy)-methyl]quinazolin-4(3H)-one derivatives as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Female; Hydrazines; Lethal Dose 50; M | 2013 |
Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats.
Topics: Aging; Allylisopropylacetamide; Amides; Animals; Anticonvulsants; Convulsants; Epilepsy, Generalized | 2013 |
Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase.
Topics: Animals; Blood-Brain Barrier; Brain; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Syntha | 2013 |
Brain MAPKs levels are differentially associated with seizures threshold and severity progression in pentylenetetrazole-kindled mice.
Topics: Animals; Brain; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protei | 2013 |
Anticonvulsant screening of luteolin in four mouse seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2013 |
Pentylenetetrazol-induced seizures are exacerbated by sleep deprivation through orexin receptor-mediated hippocampal cell proliferation.
Topics: Animals; Benzoxazoles; CA3 Region, Hippocampal; Cell Proliferation; Convulsants; Dentate Gyrus; Hipp | 2014 |
Anticonvulsant activity of ethanol extracts of Vetiveria zizanioides roots in experimental mice.
Topics: Animals; Anticonvulsants; Chrysopogon; Convulsants; Disease Models, Animal; Dose-Response Relationsh | 2013 |
The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dose-Respon | 2013 |
Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Sca | 2013 |
Effect of curcumin against pentylenetetrazol-induced seizure threshold in mice: possible involvement of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; A | 2014 |
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Cannabinoids; Cannabis; Disease Models, Animal; Dose-R | 2013 |
Antisense reduction of tau in adult mice protects against seizures.
Topics: Age Factors; Animals; Anticonvulsants; Central Nervous System; Convulsants; Disease Models, Animal; | 2013 |
Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat.
Topics: Animals; Botulinum Toxins; Botulinum Toxins, Type A; Convection; Convulsants; Disease Models, Animal | 2013 |
Piperine exerts anti-seizure effects via the TRPV1 receptor in mice.
Topics: Alkaloids; Animals; Anticonvulsants; Behavior, Animal; Benzodioxoles; Electroshock; Gene Expression | 2013 |
The auriculo-vagal afferent pathway and its role in seizure suppression in rats.
Topics: Action Potentials; Afferent Pathways; Anesthetics; Animals; Cholera Toxin; Convulsants; Disease Mode | 2013 |
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.
Topics: Abietanes; Alzheimer Disease; Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Dise | 2013 |
Design, synthesis and anticonvulsant activity evaluation of novel 4-(4-substitutedphenyl)-3-methyl-1H-1,2,4-triazol-5(4H)-ones.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Design; Drug Evaluation, Preclinical; Ele | 2014 |
Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones.
Topics: Administration, Oral; Animals; Anticonvulsants; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhib | 2013 |
GSK-3β may be involved in hippocampal mossy fiber sprouting in the pentylenetetrazole-kindling model.
Topics: Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen | 2013 |
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures.
Topics: alpha-MSH; Animals; Anti-Inflammatory Agents; Hippocampus; Interleukin-1beta; Male; Mice; Pentylenet | 2013 |
The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs.
Topics: Animals; Anticonvulsants; Carbolines; Dogs; Dose-Response Relationship, Drug; Drug Partial Agonism; | 2013 |
Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Pent | 2014 |
Design of benzothiazole-1,3,4-thiadiazole conjugates: synthesis and anticonvulsant evaluation.
Topics: Animals; Anticonvulsants; Benzothiazoles; Brain; Disease Models, Animal; Drug Design; Electroshock; | 2013 |
Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Diterpenes; Dose-Response Relatio | 2013 |
Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Disease Models, Animal; Gene Expression; Hippoca | 2014 |
Elevation of seizure threshold after intranasal administration of anti-glutamate antibodies to C57BL/6 mice.
Topics: Administration, Intranasal; Animals; Antibodies; Anticonvulsants; Dose-Response Relationship, Drug; | 2013 |
Heart rate regulation at different levels of convulsive readiness.
Topics: Animals; Autonomic Nervous System; Brain; Electroencephalography; Heart; Heart Rate; Kindling, Neuro | 2013 |
Elevated expression of pleiotrophin in pilocarpine-induced seizures of immature rats and in pentylenetetrazole-induced hippocampal astrocytes in vitro.
Topics: Animals; Astrocytes; Blotting, Western; Carrier Proteins; Cell Survival; Cells, Cultured; Cytokines; | 2014 |
In silico validation and structure activity relationship study of a series of pyridine-3-carbohydrazide derivatives as potential anticonvulsants in generalized and partial seizures.
Topics: Animals; Anticonvulsants; Computer Simulation; Cornea; Dose-Response Relationship, Drug; Drug Design | 2013 |
Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Marsileaceae; Pentylenet | 2013 |
Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Electroencephalograp | 2013 |
Anticonvulsant activity of Aloe vera leaf extract in acute and chronic models of epilepsy in mice.
Topics: Aloe; Animals; Antioxidants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2014 |
Synthesis, anticonvulsant and neurotoxicity evaluation of some newer N-(2-benzoylbenzofuran-3-yl)-3-(substituted)-propanamide analogs.
Topics: Animals; Anticonvulsants; Benzofurans; Convulsants; Drug Design; Electroshock; Indicators and Reagen | 2013 |
CNS depressant and anticonvulsant activities of the alcoholic extract of leaves of Ziziyphus nummularia.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Dose-Response Relationship, Drug; Female; Hy | 2014 |
The rearrangement of filamentous actin in mossy fiber synapses in pentylenetetrazol-kindled C57BL/6 mice.
Topics: Actin Cytoskeleton; Animals; CA3 Region, Hippocampal; Kindling, Neurologic; Male; Mice; Mice, Inbred | 2014 |
Antiepileptic potential of matrine via regulation the levels of gamma-aminobutyric acid and glutamic acid in the brain.
Topics: Alkaloids; Animals; Anticonvulsants; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate Decarb | 2013 |
Delayed effect of craniotomy on experimental seizures in rats.
Topics: Animals; Craniotomy; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Skull | 2013 |
Prostaglandin D(2) is crucial for seizure suppression and postictal sleep.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Brain; Convulsants; Dinoprostone; Disea | 2014 |
Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood-Brain Barrier; Brain; Brain-Derived Neurotrophic F | 2013 |
Antiepileptic potential of Anisomeles indica (Linn.) Kuntze aerial parts in pentylenetetrazole-induced experimental convulsions in Wistar rats.
Topics: Animals; Anticonvulsants; Convulsants; Female; Lamiaceae; Male; Pentylenetetrazole; Plant Components | 2013 |
Investigation of compositional, structural, and dynamical changes of pentylenetetrazol-induced seizures on a rat brain by FT-IR spectroscopy.
Topics: Animals; Brain; Cluster Analysis; Dose-Response Relationship, Drug; Lipid Peroxidation; Male; Pentyl | 2014 |
The analgesic and anticonvulsant effects of piperine in mice.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anticonvulsants; Benzodioxoles; Hot Temperature; Male; | 2013 |
Erythropoietin pretreatment suppresses seizures and prevents the increase in inflammatory mediators during pentylenetetrazole-induced generalized seizures.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Convulsants; Cytokines; Drug Administration | 2014 |
Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat.
Topics: Analysis of Variance; Animals; Cognition Disorders; Convulsants; Disease Models, Animal; Dose-Respon | 2014 |
Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models.
Topics: Acute Disease; Administration, Oral; Animals; Anticonvulsants; Chronic Disease; Convulsants; Disease | 2016 |
[Combined blockade of AMPA- and NMDA-receptors has maximum effect to eliminate development of pentylenetetrazole-induced kindling in rats].
Topics: Adamantane; Administration, Oral; Animals; Anticonvulsants; Drug Administration Schedule; Male; Pent | 2013 |
Effect of prenatal forced-swim stress and morphine co-administration on pentylentetrazol-induced epileptic behaviors in infant and prepubertal rats.
Topics: Animals; Animals, Newborn; Body Weight; Female; Male; Morphine; Narcotics; Pentylenetetrazole; Pregn | 2014 |
Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability.
Topics: 4-Aminopyridine; Animals; Disease Models, Animal; Entorhinal Cortex; Hydrogen Sulfide; Magnesium Def | 2014 |
Understanding the anti-kindling role and its mechanism of Resveratrol in Pentylenetetrazole induced-kindling in a rat model.
Topics: Animals; Anticonvulsants; Antioxidants; Caspase 3; Convulsants; Hippocampus; Kindling, Neurologic; L | 2014 |
Revealing pharmacodynamics of medicinal plants using in silico approach: a case study with wet lab validation.
Topics: 4-Aminobutyrate Transaminase; Analysis of Variance; Animals; Anticonvulsants; Computational Biology; | 2014 |
Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice.
Topics: Analysis of Variance; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
Synthesis, receptor affinity and effect on pentylenetetrazole-induced seizure threshold of novel benzodiazepine analogues: 3-Substituted 5-(2-phenoxybenzyl)-4H-1,2,4-triazoles and 2-amino-5-(phenoxybenzyl)-1,3,4-oxadiazoles.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Models, Molecular; Mole | 2014 |
Non-invasive detection of optical changes elicited by seizure activity using time-series analysis of light scattering images in a rat model of generalized seizure.
Topics: Algorithms; Animals; Brain; Brain Mapping; Convulsants; Disease Models, Animal; Electroencephalograp | 2014 |
[Action of reserpine on the chemical changes in the blood during pentylenetetrazole shock in the rabbit].
Topics: Animals; Blood; Blood Chemical Analysis; Pentylenetetrazole; Rabbits; Reserpine; Seizures; Shock | 1960 |
Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Eclampsia; Female; Humans; Lipopolysaccharides; Ma | 2014 |
Pam heterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function.
Topics: Adenosine Triphosphatases; Amygdala; Animals; Behavior, Animal; Cation Transport Proteins; Copper; C | 2014 |
Modulation of c-Fos and BDNF protein expression in pentylenetetrazole-kindled mice following the treatment with novel antiepileptic compound HHL-6.
Topics: Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy | 2014 |
Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles.
Topics: Animals; Anticonvulsants; Heterocyclic Compounds; Male; Mice; Molecular Structure; Pentylenetetrazol | 2014 |
Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.
Topics: Aggression; Anilides; Animals; Anxiety; Behavior, Animal; Brain; Child Development Disorders, Pervas | 2014 |
The role of interleukin-1β in the pentylenetetrazole-induced kindling of seizures, in the rat hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Hippocampus; Interleukin-1beta; Interleukin-6; Kindling, | 2014 |
Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se.
Topics: Animals; Anticonvulsants; Cannabidiol; Cannabinoids; Cells, Cultured; Cerebral Cortex; Cricetulus; F | 2014 |
Roles of Rho guanine nucleotide triphosphatases in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Gene Expression Regulatio | 2014 |
Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model.
Topics: Animals; Docosahexaenoic Acids; Injections, Intraperitoneal; Male; Pentylenetetrazole; Rats; Rats, W | 2014 |
Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels.
Topics: Amidohydrolases; Anilides; Animals; Anticonvulsants; Arachidonic Acids; Cinnamates; Male; Mice; Pent | 2014 |
Esters of valerenic acid as potential prodrugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Esters; GABA Agents; Inden | 2014 |
The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Hippocampus; Male; Mice, Inbred ICR; Ondansetron; | 2014 |
Design, synthesis and pharmacological evaluation of N3 aryl/ heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7- dimethoxyquinazolin-4(3H)-ones as potential anticonvulsant agents.
Topics: Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 2014 |
Effect of edaravone on apoptosis of hippocampus neuron in seizures rats kindled by pentylenetetrazole.
Topics: Animals; Antipyrine; Apoptosis; Caspase 3; Edaravone; fas Receptor; Hippocampus; Kindling, Neurologi | 2014 |
The association between seizure predisposition and inflammation in a rat model of fatty liver disease.
Topics: Animals; Brain; Convulsants; Disease Susceptibility; Electroencephalography; Fatty Liver; Fructose; | 2014 |
Nitric oxide mediates the anticonvulsant effects of thalidomide on pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2014 |
Pharmacological and structure-activity relationship evaluation of 4-aryl-1-diphenylacetyl(thio)semicarbazides.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Male; Mice; Molecular Conformation; Molecular Doc | 2014 |
Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model.
Topics: Animals; Anticonvulsants; Clomiphene; Convulsants; Diazepam; Disease Models, Animal; Estriol; Female | 2014 |
Synthesis, anticonvulsant and antimicrobial activities of some new [1-(2-naphthyl)-2-(pyrazol-1-yl)ethanone]oxime ethers.
Topics: Animals; Anticonvulsants; Antifungal Agents; Candida; Convulsants; Crystallography, X-Ray; Electrosh | 2014 |
Intrinsic connections within the pedunculopontine tegmental nucleus are critical to the elaboration of post-ictal antinociception.
Topics: Animals; Catheters, Indwelling; Central Nervous System Agents; Cobalt; Male; Nociception; Pain Measu | 2014 |
Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.
Topics: Animals; Antioxidants; Brain; Convulsants; Glutathione; Kindling, Neurologic; Learning Disabilities; | 2014 |
Acute and chronic effects of agomelatine on intravenous penthylenetetrazol-induced seizure in mice and the probable role of nitric oxide.
Topics: Acetamides; Administration, Intravenous; Animals; Anticonvulsants; Convulsants; Guanidines; Indazole | 2014 |
Age and activation determines the anticonvulsant effect of ifenprodil in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Electric Stimulation; Male; Pentylenetetrazole; P | 2014 |
Convulsive liability of cefepime and meropenem in normal and corneal kindled mice.
Topics: Animals; Anti-Bacterial Agents; Cefepime; Cephalosporins; Convulsants; Disease Susceptibility; Drug | 2014 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazep | 2014 |
Effect of quercetin and rutin in some acute seizure models in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Ther | 2014 |
Dynamic expression patterns of ATF3 and p53 in the hippocampus of a pentylenetetrazole-induced kindling model.
Topics: Activating Transcription Factor 3; Animals; Behavior, Animal; Disease Models, Animal; Hippocampus; I | 2014 |
Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Convulsants; Disease Models, Animal; Electroenceph | 2015 |
Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics.
Topics: Animals; Brain; Classical Lissencephalies and Subcortical Band Heterotopias; Dose-Response Relations | 2014 |
Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.
Topics: Acute Disease; Amino Acids, Dicarboxylic; Animals; Brain; Central Nervous System Agents; Chronic Dis | 2014 |
Proconvulsant effects of tramadol and morphine on pentylenetetrazol-induced seizures in adult rats using different routes of administration.
Topics: Analgesics; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Adm | 2014 |
Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.
Topics: Adamantane; Amines; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Excitat | 2014 |
Effects of grape seed proanthocyanidin extract on pentylenetetrazole-induced kindling and associated cognitive impairment in rats.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Free Radicals; Grape Seed Extract; Humans; Kindling, N | 2014 |
Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram.
Topics: Animals; Anticonvulsants; Cell Line; Clonazepam; Drug Carriers; Electroencephalography; Humans; Lipi | 2014 |
Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroshock; Ligands; Male; Mic | 2014 |
The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide.
Topics: Animals; Arginine; Brain; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Guanidines; | 2014 |
Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.
Topics: Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Chemistry Techniques, Synthetic; GABA U | 2014 |
Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug C | 2014 |
Design and synthesis of new of 3-(benzo[d]isoxazol-3-yl)-1-substituted pyrrolidine-2, 5-dione derivatives as anticonvulsants.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Electroshock; Isoxazoles; M | 2014 |
ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamates; Male; Mice; Mice, Knockout; Monoacylg | 2014 |
Ultrasound-assisted synthesis, anticonvulsant activity, and docking study of indole-appended thiazolidin-4-ones.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Design; Electroshock; Indol | 2014 |
Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Female; GAP-43 Protein; Ibotenic Acid; Int | 2015 |
Synthesis and anticonvulsant activity of novel purine derivatives.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Mice; Motor Activity; Pentylenetetra | 2014 |
Normotopic cortex is the major contributor to epilepsy in experimental double cortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Classical Lissencephalies and Subcortical Band Heterotopias; | 2014 |
Anticonvulsant and behavioral effects of muscimol in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Dr | 2014 |
Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction.
Topics: Acetates; Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Capillary Permeability; Chromones; C | 2014 |
Behavioral characterization of striatal-enriched protein tyrosine phosphatase (STEP) knockout mice.
Topics: Animals; Brain; Exploratory Behavior; Locomotion; Maze Learning; Mice; Mice, Inbred C57BL; Pentylene | 2014 |
Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum.
Topics: Animals; Anticonvulsants; Biological Assay; Chemical Fractionation; Chromatography, High Pressure Li | 2014 |
Synthesis, physicochemical, and anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Female; Gabapentin; | 2014 |
Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Male; Mice; N-Methylaspartate; Nitric | 2014 |
A single episode of juvenile status epilepticus reduces the threshold to adult seizures in a stimulus-specific way.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Disease Progression; Female; Male; M | 2014 |
Monoterpenoid terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding Sites; Electrophysiological Phenomena; Flumazeni | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2014 |
Synthesis, anticonvulsant properties, and SAR analysis of differently substituted pyrrolidine-2,5-diones and piperidine-2,6-diones.
Topics: Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Drug Design; Electric Stimulation; Hip | 2014 |
Anticonvulsant and antioxidant effects of Tilia americana var. mexicana and flavonoids constituents in the pentylenetetrazole-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Chromatography, High Pressure Liquid; Female; Flavonoids; Fl | 2014 |
Gestational treatment of folic acid attenuates blood-brain barrier leakage in pregnant- and prepubertal rats after pentylenetetrazole-induced seizure.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Epilepsy; Female; Folic Acid; Glial Fibrillary Acidic | 2016 |
The role of alpha-2 adrenoceptors in the anticonvulsant effects of adenosine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic | 2014 |
Anticonvulsant profiles of certain new 6-aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones.
Topics: Animals; Anticonvulsants; Convulsants; Diketopiperazines; Dose-Response Relationship, Drug; Drug Eva | 2014 |
Design, synthesis, and biological evaluation of hydrazone incorporated 1,2,4-triazines as anticonvulsant agents.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Binding Sites; Catalytic Domain; Computer-Ai | 2014 |
Ozone protective effects against PTZ-induced generalized seizures are mediated by reestablishment of cellular redox balance and A1 adenosine receptors.
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, An | 2015 |
Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency.
Topics: Animals; Anticonvulsants; Caprylates; Diet, Ketogenic; Hippocampus; Histone Deacetylase Inhibitors; | 2015 |
N-methyl-D-aspartate receptor channel blockers prevent pentylenetetrazole-induced convulsions and morphological changes in rat brain neurons.
Topics: Animals; Brain; Caspase 3; Cell Shape; Cyclohexylamines; Excitatory Amino Acid Antagonists; Male; Me | 2015 |
Sertraline reduces IL-1β and TNF-α mRNA expression and overcomes their rise induced by seizures in the rat hippocampus.
Topics: Animals; Antidepressive Agents; Gene Expression Regulation; Hippocampus; Inflammation Mediators; Int | 2014 |
'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.
Topics: Action Potentials; Alternative Splicing; Animals; Animals, Newborn; Behavior, Animal; Brain; Disease | 2015 |
Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures.
Topics: Animals; Convulsants; Disease Models, Animal; Disease Susceptibility; Electroshock; Female; Fever; M | 2014 |
Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Convulsants; Diet, High-Fat; Disease Models, Anima | 2014 |
Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Lythra | 2015 |
Synthesis and antiepileptic activity of schiff's bases of dialkylamino alkoxy isatin derivatives.
Topics: Alcohols; Animals; Anticonvulsants; Electroshock; Hydrazones; Indoles; Isatin; Magnetic Resonance Sp | 2015 |
Potential roles of the RGMa-FAK-Ras pathway in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model.
Topics: Animals; Behavior, Animal; CA3 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2015 |
Thymoquinone and vitamin C attenuates pentylenetetrazole-induced seizures via activation of GABAB1 receptor in adult rats cortex and hippocampus.
Topics: Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Benzoquinones; Calcium-Calmodulin-Dependent P | 2015 |
[The ability of NMDA glutamate receptor blockers to prevent a pentylenetetrazole kindling in mice and morphological changes in the hippocampus].
Topics: Animals; DNA-Binding Proteins; Hippocampus; Kindling, Neurologic; Memantine; Mice; Nerve Tissue Prot | 2013 |
Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography.
Topics: Algorithms; Animals; Brain; Cerebrovascular Circulation; Computer Graphics; Computer Simulation; Dis | 2015 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, | 2015 |
Hypoxia/ischemia a key player in early post stroke seizures: modulation by opioidergic and nitrergic systems.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Cell Hypoxia; Drug Synergism; GABA Antagonists; Male; M | 2015 |
Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection.
Topics: Animals; Cognition Disorders; Convulsants; Flavanones; Inflammation; Neuroprotective Agents; Oxidati | 2014 |
Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice.
Topics: Animals; Arginine; Convulsants; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Male; Mice; | 2014 |
[Stimulation of gastric mucosa afferents by phenylephrine potentiates anticonvulsive and eliminates sedative action of sodium valproate in the pentylenetetrazol kindling model in rats].
Topics: Afferent Pathways; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Dru | 2014 |
Positive effects of ceftriaxone on pentylenetetrazol-induced convulsion model in rats.
Topics: Animals; Anticonvulsants; Brain; Ceftriaxone; Convulsants; Dose-Response Relationship, Drug; Drug Ev | 2016 |
Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats.
Topics: Animals; Anticonvulsants; Brain; Glutamate Decarboxylase; Male; Neurons; Oligopeptides; Pentylenetet | 2015 |
An antagonist of calcium permeable AMPA receptors, IEM1460: Anticonvulsant action in immature rats?
Topics: Adamantane; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Dru | 2015 |
Anticonvulsant activity of Citrus aurantium blossom essential oil (neroli): involvment of the GABAergic system.
Topics: Animals; Anticonvulsants; Benzodiazepines; Citrus; Cyclohexane Monoterpenes; Cyclohexenes; Flowers; | 2014 |
Age-dependent long-term structural and functional effects of early-life seizures: evidence for a hippocampal critical period influencing plasticity in adulthood.
Topics: Animals; Animals, Newborn; Atrophy; Corpus Callosum; Diffusion Tensor Imaging; Disease Models, Anima | 2015 |
Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Diphosphate; Animals; Benzyl Compou | 2015 |
Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?
Topics: Animals; Anticonvulsants; Convulsants; Databases, Bibliographic; Disease Models, Animal; Electroshoc | 2015 |
Increase of the seizure threshold in C57BL/6 mice after citicoline administration.
Topics: Animals; Convulsants; Cytidine Diphosphate Choline; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazo | 2015 |
Effect of ACE inhibitors and AT1 receptor antagonists on pentylenetetrazole-induced convulsions in mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticonv | 2015 |
Fluvoxamine alleviates seizure activity and downregulates hippocampal GAP-43 expression in pentylenetetrazole-kindled mice: role of 5-HT3 receptors.
Topics: Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Fluvoxamine; GAP-43 Protein; Hippocamp | 2015 |
Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Child Development Disorders, Pervasive; Dose-Response Re | 2015 |
Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats.
Topics: Animals; Benzoxazoles; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Isoquinolin | 2015 |
Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice.
Topics: Acetylcholinesterase; Animals; Anxiety; Cognition; Cognition Disorders; Convulsants; Freeze Drying; | 2015 |
Alteration of pentylenetetrazole-induced seizure threshold by chronic administration of ginger (Zingiber officinale) extract in male mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Plant Ex | 2015 |
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Epilepsy, Temporal Lobe; Female; Gene Regulator | 2015 |
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; | 2015 |
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole; | 2015 |
Methanol extract of Ficus platyphylla ameliorates seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Brain; Ficus; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Kindling, | 2015 |
Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures.
Topics: Animals; Anticonvulsants; Carrier Proteins; Convulsants; Disease Models, Animal; Electroshock; Homer | 2015 |
Anticonvulsant activity of the cyclooxygenase-2 (COX-2) inhibitor etoricoxib in pentylenetetrazole-kindled rats is associated with memory impairment.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Cyclooxygenase 2 Inhibitors; Etoricoxib; Ki | 2015 |
Proconvulsant effect of post-weaning social isolation stress may be associated with dysregulation of opioid system in the male mice.
Topics: Animals; Brain; Convulsants; Male; Mice; Models, Biological; Morphine; Pentylenetetrazole; Receptors | 2015 |
Montelukast potentiates the anticonvulsant effect of phenobarbital in mice: an isobolographic analysis.
Topics: Acetates; Animals; Anticonvulsants; Convulsants; Cyclopropanes; Dose-Response Relationship, Drug; Dr | 2015 |
Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Avoidance Learning; Convulsants; Dendrites; | 2015 |
Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice.
Topics: Animals; Antidiarrheals; Constipation; Convulsants; Disease Models, Animal; Drug Interactions; Gastr | 2015 |
Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hydrazines; Mice; Models, Molecular; Mol | 2015 |
α-Spinasterol, a TRPV1 receptor antagonist, elevates the seizure threshold in three acute seizure tests in mice.
Topics: Animals; Anticonvulsants; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug | 2015 |
New benzo[d]thiazol-2-yl-aminoacetamides as potential anticonvulsants: synthesis, activity and prediction of molecular properties.
Topics: Acetamides; Animals; Anticonvulsants; Benzothiazoles; Carbamazepine; Computer Simulation; Disease Mo | 2015 |
Montelukast inhibits pentylenetetrazol-induced seizures in rats.
Topics: Acetates; Action Potentials; Animals; Brain; Cyclopropanes; Electroencephalography; Male; Malondiald | 2015 |
Down-regulation of Homer1b/c protects against chemically induced seizures through inhibition of mTOR signaling.
Topics: Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Down-Regulation; Glycine; Hippo | 2015 |
Protective effects of lithium chloride on seizure susceptibility: Involvement of α2-adrenoceptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzofurans; | 2015 |
Different preparations, doses, and treatment regimens of cyclosporine A cause adverse effects but no robust changes in seizure thresholds in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Body Weight; Convulsants; Cyclosp | 2015 |
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.
Topics: Amides; Animals; Anticonvulsants; Benzylamines; Convulsants; Disease Models, Animal; Dose-Response R | 2015 |
Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal.
Topics: Alcoholism; Animals; Anticonvulsants; Ethosuximide; Male; Mice; Mice, Inbred DBA; Mortality; Pentyle | 2015 |
Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats.
Topics: Acute Disease; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Synthesis, Biological Activity, and Docking Study of Novel Isatin Coupled Thiazolidin-4-one Derivatives as Anticonvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding Sites; Computer-Aided Design; Disease Models, An | 2015 |
Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§.
Topics: Acetylcholine; Amphetamines; Animals; Biogenic Monoamines; Body Temperature; Brain; Calcium Channels | 2015 |
Seizure susceptibility to electroconvulsions or pentylenetetrazol after complete cerebral ischemia in rats due to cardiac arrest.
Topics: Animals; Brain Ischemia; Electroshock; Female; Heart Arrest; Pentylenetetrazole; Rats; Rats, Wistar; | 2015 |
Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Apoptosis; CA3 Region, Hippocampal | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, | 2015 |
The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide.
Topics: Animals; Anticonvulsants; Arginine; Aripiprazole; Convulsants; Electroshock; Guanidines; Indazoles; | 2015 |
Vitis labrusca leaf extract prevents pentylenetetrazol-induced oxidative damage but not seizures in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hippoca | 2015 |
Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure.
Topics: Acetoacetates; Administration, Oral; Analysis of Variance; Animals; Anticonvulsants; Butylene Glycol | 2015 |
Synthesis and Anticonvulsant Activity of Substituted-1,3-diazaspiro[4.5]decan-4-ones.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Drug Design; Electroshock | 2015 |
Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats.
Topics: Animals; Brain; Ceftriaxone; Cognition Disorders; Convulsants; Dose-Response Relationship, Drug; Epi | 2015 |
The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Arginine; Aripiprazole; Convulsants; Dose-Response R | 2015 |
Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats.
Topics: Animals; Anticonvulsants; Anxiety; Avoidance Learning; Cognition Disorders; Convulsants; DNA Damage; | 2015 |
Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Larva; Mechanistic Target of Rapamyci | 2015 |
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Brain; Disease Models, Animal; Drug Design; | 2015 |
Anticonvulsant and Neurotoxicity of Some Novel 1-([1,3,4]thiadiazino[6,5- b]indol-3-yl Semicarbazides.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Male; Mi | 2015 |
proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.
Topics: Action Potentials; Aminoquinolines; Animals; Brain-Derived Neurotrophic Factor; Carbachol; Cells, Cu | 2015 |
Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole.
Topics: Animals; Cynanchum; Disease Models, Animal; Drugs, Chinese Herbal; Glycosides; Molecular Structure; | 2015 |
Unilateral microinjection of carbenoxolone into the pontis caudalis nucleus inhibits the pentylenetetrazole-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Carbenoxolone; Epilepsy; Male; Microinjections; Pentylenetetrazole; Pontin | 2015 |
Intravenous infusion of docosahexaenoic acid increases serum concentrations in a dose-dependent manner and increases seizure latency in the maximal PTZ model.
Topics: Animals; Anticonvulsants; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Infusions, Intrav | 2015 |
Anticonvulsant properties of Euterpe oleracea in mice.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Euterpe; Male; Mice; Oxidativ | 2015 |
Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Brain; Cognition; Cognition Diso | 2016 |
N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols-their physicochemical and anticonvulsant properties.
Topics: Animals; Anticonvulsants; Chemistry Techniques, Synthetic; Disease Models, Animal; Drug Evaluation, | 2015 |
Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish).
Topics: Animals; Anticonvulsants; Behavior, Animal; Indenes; Pentylenetetrazole; Plant Extracts; Seizures; S | 2015 |
A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blood-Brain Barrier; Capillary Permeabi | 2015 |
Quetiapine attenuates cognitive impairment and decreases seizure susceptibility possibly through promoting myelin development in a rat model of malformations of cortical development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Cognition Disorders; Corpus Callosum; D | 2015 |
Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Down-Regulation; Hippocampus; Homeodomain Proteins | 2015 |
Reversal of P-glycoprotein overexpression by Ginkgo biloba extract in the brains of pentylenetetrazole-kindled and phenytoin-treated mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caspase 3; Disease Models, | 2015 |
Increased sensitivity to kindling in mice lacking TSP1.
Topics: Animals; Calcium Channels; Disease Models, Animal; Kindling, Neurologic; Male; Mice; Mice, Transgeni | 2015 |
Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Brain Chemistry; Cognition Disorders; Glutathione | 2015 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; D | 2015 |
3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice.
Topics: Animals; Anticonvulsants; Cinnamates; Electroshock; Flumazenil; GABA Antagonists; Male; Mice; Pentyl | 2016 |
Anticonvulsant activity of methanolic extract from Kalanchoe pinnata Lam. stems and roots in mice: A comparison to diazepam.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Female; Kalanchoe; Male; Methanol; Mice; Mice, Inbr | 2016 |
Discovery of benzothiazine derivatives as novel, orally-active anti-epileptic drug candidates with broad anticonvulsant effect.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Ethanolamines; Kindling, Neurologic; Male; | 2015 |
Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model.
Topics: Animals; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Autoantibodies; Brain; Convulsants; Diseas | 2015 |
Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery.
Topics: Aluminum Silicates; Animals; Brain; Cell Survival; Clay; Drug Carriers; Drug Liberation; Drug Stabil | 2015 |
Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats.
Topics: Animals; Antioxidants; Biological Availability; Brain; Central Nervous System Depressants; Disease M | 2015 |
Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition.
Topics: Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Male; Neural Inhibition; Pentylenetetrazole; R | 2015 |
Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Brain; Calcium Channel Blockers; Calcium Channels, | 2016 |
Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate.
Topics: Animals; Anticonvulsants; Behavior, Animal; Coumaric Acids; Male; Mice; Motor Activity; Muscle Relax | 2015 |
Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Design; Male; Mice; Molecular Structur | 2015 |
Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Histamine | 2015 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Resp | 2015 |
Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers.
Topics: Animals; Anticonvulsants; Cyclohexane Monoterpenes; Electroshock; Male; Mice; Molecular Structure; M | 2015 |
Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.
Topics: Animals; Biomarkers; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Female; Lithium; Male; | 2015 |
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Survival; Disease Models, Animal; Excitatory Ami | 2016 |
Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Drug Evalu | 2016 |
Mechanism of action of antiepileptic ceramide from Red Sea soft coral Sarcophyton auritum.
Topics: Allosteric Regulation; Animals; Anthozoa; Anticonvulsants; Binding Sites; Ceramides; Disease Models, | 2015 |
Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine.
Topics: Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Antiparkinson Agents; Bridged-Ring Comp | 2015 |
A Highly Selective Inhibitor of Glycine Transporter-1 Elevates the Threshold for Maximal Electroshock-Induced Tonic Seizure in Mice.
Topics: Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Electroshock; Glycine Plasma | 2016 |
Neuroprotective Effect of Lycopene Against PTZ-induced Kindling Seizures in Mice: Possible Behavioural, Biochemical and Mitochondrial Dysfunction.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Carotenoids; Catalase; Dose-Response Relationship, D | 2016 |
Anticonvulsant Activity of Hydroalcoholic Extract of Citrullus colocynthis Fruit: Involvement of Benzodiazepine and Opioid Receptors.
Topics: Animals; Anticonvulsants; Benzodiazepines; Citrullus colocynthis; Flavonoids; Flumazenil; Fruit; Her | 2016 |
LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization.
Topics: Animals; Cell Movement; Cells, Cultured; Cerebral Cortex; Electroporation; Gene Knockdown Techniques | 2016 |
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M | 2016 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; G | 2015 |
Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents.
Topics: Animals; Anticonvulsants; Azepines; Carboxylic Acids; GABA-A Receptor Agonists; Hypnotics and Sedati | 2016 |
Optimal Vagus Nerve Stimulation Frequency for Suppression of Spike-and-Wave Seizures in Rats.
Topics: Animals; Heart Rate; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Vagus Nerve; Va | 2016 |
Chaihushugan decoction exerts antiepileptic effects by increasing hippocampal glutamate metabolism in pentylenetetrazole-kindled rats.
Topics: Animals; Anticonvulsants; Drugs, Chinese Herbal; Glutamates; Hippocampus; Humans; Male; Pentylenetet | 2015 |
Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205.
Topics: Animals; Anticonvulsants; Benzimidazoles; Kindling, Neurologic; Male; Mice; Morpholines; Pentylenete | 2016 |
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2016 |
Effectiveness of ketogenic diet in pentylenetetrazol-induced and kindling rats as well as its potential mechanisms.
Topics: Animals; Diet, Ketogenic; K Cl- Cotransporters; Kindling, Neurologic; Male; Pentylenetetrazole; Rats | 2016 |
Different calorie restriction treatments have similar anti-seizure efficacy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Blood Glucose; Body Weight; Butylene Glycols; Calori | 2016 |
The Influence of Vagus Nerve and Spinal Cord Stimulation on the Ictal Fast Ripple Activity in a Spike-and-Wave Rat Model of Seizures.
Topics: Animals; Biophysics; Brain Waves; Disease Models, Animal; Electroencephalography; Male; Pentylenetet | 2016 |
Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Enzyme Inhibitors; Gene Exp | 2016 |
Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer's Disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brai | 2016 |
Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Epi | 2016 |
NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Dizocilpine Maleate; Dose-Response R | 2016 |
A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Diazoxide; Disease Models, Animal; Dose | 2016 |
The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Autistic Disorder; Behavior, Animal; Convulsants; Disease Mod | 2016 |
The interaction between morphine and propranolol in chemical and electrical seizure models of mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrat | 2016 |
Design, synthesis, pharmacological evaluation, and docking study of new acridone-based 1,2,4-oxadiazoles as potential anticonvulsant agents.
Topics: Acridines; Acridones; Animals; Anticonvulsants; Electroshock; Mice; Molecular Docking Simulation; Ox | 2016 |
Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Immunohistochemistry; Male; Membrane Potentials; M | 2017 |
Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats.
Topics: Animals; Anticonvulsants; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combin | 2016 |
Montelukast reduces seizures in pentylenetetrazol-kindled mice.
Topics: Acetates; Animals; Anticonvulsants; Blotting, Western; Convulsants; Cyclopropanes; Kindling, Neurolo | 2016 |
SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice.
Topics: Animals; Anticonvulsants; Benzoxazoles; Brain Chemistry; Convulsants; Electroshock; Male; Mice; Musc | 2016 |
Pharmacological evaluation of novel 1-[4-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Antidepressive Agents; Disease Models, Animal; E | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Benzothiazoles; Convulsants; Disease Models, Animal; Drug Design; Electros | 2016 |
Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Disease Models, Animal; D | 2016 |
Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling.
Topics: Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction | 2016 |
Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electros | 2016 |
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models.
Topics: Animals; Basal Ganglia; Disease Models, Animal; Electric Stimulation; Female; gamma-Aminobutyric Aci | 2016 |
Design, Synthesis, and Biological Evaluation of 6-(2-Amino-substituted phenyl)-4-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Brain; Electroshock; gamma-Aminobutyric Acid; Mice; Molecular Docking Simu | 2016 |
Synthesis of Novel 8-alkylamino-5, 6-dihydro-4H-benzo[f] [1,2,4]triazolo [4,3-a]azepines as Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Azepines; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2016 |
Wnt/β-catenin signaling mediates the seizure-facilitating effect of postischemic reactive astrocytes after pentylenetetrazole-kindling.
Topics: Animals; Astrocytes; beta Catenin; Ischemia; Male; Mice, Inbred C57BL; Pentylenetetrazole; Seizures; | 2016 |
Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2016 |
New partners and phosphorylation sites of focal adhesion kinase identified by mass spectrometry.
Topics: Animals; Animals, Newborn; Binding Sites; Brain; Catalytic Domain; Chromatography, Liquid; Disease M | 2016 |
[(18)F]FDG PET Neuroimaging Predicts Pentylenetetrazole (PTZ) Kindling Outcome in Rats.
Topics: Animals; Disease Progression; Fluorodeoxyglucose F18; Kindling, Neurologic; Magnetic Resonance Imagi | 2016 |
Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Blood Pressure; CA1 Region, Hippocampa | 2016 |
Anticonvulsant Activity of Enantiomeric N-trans-Cinnamoyl Derivatives of 2-Aminopropan-1-ols and 2-Aminobutan-1-ols.
Topics: Animals; Anticonvulsants; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Cytochrome P-450 | 2016 |
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Disease Susceptibility; Mice; Mice, Inbred C57B | 2016 |
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Topics: Age Factors; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-R | 2016 |
Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Indenes; Mice; Pentylenetetrazo | 2016 |
Oxytocin is involved in the proconvulsant effects of Sildenafil: Possible role of CREB.
Topics: Animals; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus | 2016 |
Synthesis and Anticonvulsant Activity of N-(Substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Methaqualone; Mice; Pentyl | 2016 |
Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system.
Topics: Animals; Anticonvulsants; Convulsants; Hippocampus; Lithium Chloride; Male; Mice; Nitric Oxide; Nitr | 2016 |
Resveratrol suppressed seizures by attenuating IL-1β, IL1-Ra, IL-6, and TNF-α in the hippocampus and cortex of kindled mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Avoidance Learning; | 2017 |
CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus.
Topics: Animals; Brain Injuries; Hippocampus; Male; Pentylenetetrazole; Piperidines; Pyrazoles; Rats; Rats, | 2016 |
Microarray Noninvasive Neuronal Seizure Recordings from Intact Larval Zebrafish.
Topics: Action Potentials; Animals; Brain; Electroencephalography; Electrophysiological Phenomena; Epilepsy; | 2016 |
5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Brain Stem; Disease Models, Animal; Dose-Respons | 2016 |
Ketogenic diet attenuates spatial and item memory impairment in pentylenetetrazol-kindled rats.
Topics: Animals; Body Weight; Diet, Ketogenic; Kindling, Neurologic; Male; Maze Learning; Memory Disorders; | 2016 |
Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Cognition; Convulsants; Dose-Response Relationship, Drug; | 2016 |
Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin.
Topics: Amides; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Drug Design; Elect | 2016 |
Ketogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Animals; Blood Glucose; Body Weight; Convulsants; Diet, Ke | 2016 |
Lateral hypothalamus orexinergic system modulates the stress effect on pentylenetetrazol induced seizures through corticotropin releasing hormone receptor type 1.
Topics: Aniline Compounds; Animals; Hypothalamic Area, Lateral; Male; Orexins; Pentylenetetrazole; Pyrimidin | 2016 |
Protective Effect of Nerolidol Against Pentylenetetrazol-Induced Kindling, Oxidative Stress and Associated Behavioral Comorbidities in Mice.
Topics: Animals; Behavior, Animal; Comorbidity; Depression; Glutathione; Kindling, Neurologic; Male; Memory | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
Topics: Animals; Anticonvulsants; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; | 2016 |
Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Behavior, Animal; Biomarkers; Brain; Brain Waves; Disease Mo | 2016 |
Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cinnamates; Depsides; Dose-Response Relationship, Drug; | 2016 |
15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes.
Topics: Animals; Auditory Perceptual Disorders; Autistic Disorder; Behavior, Animal; Chromosome Deletion; Ch | 2016 |
Anticonvulsant activities of Sambucus nigra.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Mice; Pentylenetetrazole; Plant Extracts | 2016 |
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Caffeic Acids; Cinnamates; Comet Assay; Depsides; | 2016 |
The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice.
Topics: Animals; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Arginine; Arginine Vasopressin; | 2016 |
Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures.
Topics: Animals; Anticonvulsants; Brain Chemistry; Glutathione; Iridoid Glycosides; Male; Mice; Pentylenetet | 2016 |
Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Cromakalim; Dose-Response Relationship, Drug; Drug The | 2016 |
The effect of leptin, ghrelin, and neuropeptide-Y on serum Tnf-Α, Il-1β, Il-6, Fgf-2, galanin levels and oxidative stress in an experimental generalized convulsive seizure model.
Topics: Animals; Cytokines; Disease Models, Animal; Fibroblast Growth Factor 2; Galanin; Ghrelin; Interleuki | 2017 |
Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognitive Dysfunction; Coumaric Acids; D | 2017 |
Interactive effects of prenatal exposure to restraint stress and alcohol on pentylenetetrazol-induced seizure behaviors in rat offspring.
Topics: Animals; Animals, Newborn; Corticosterone; Ethanol; Female; Male; Pentylenetetrazole; Pregnancy; Pre | 2016 |
Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Animal; Co | 2016 |
Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception.
Topics: Acetylcholine; Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Locus Co | 2016 |
In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Electroshock; | 2017 |
Resveratrol lacks protective activity against acute seizures in mouse models.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; El | 2016 |
A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.
Topics: Animals; Brain-Computer Interfaces; Epilepsy; Female; Male; Pentylenetetrazole; Rats, Long-Evans; Se | 2016 |
The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoids; Catheters, Indwelling; Convulsants; Dose-Respo | 2016 |
Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions.
Topics: Animals; Brain Waves; Cell Count; Cell Differentiation; Convulsants; Female; GABA Antagonists; GABAe | 2016 |
Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide.
Topics: Acetic Acid; Acyclic Monoterpenes; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Cyclohexa | 2017 |
Fingolimod enhances myelin repair of hippocampus in pentylenetetrazol-induced kindling model.
Topics: Animals; Anti-Inflammatory Agents; Fingolimod Hydrochloride; Hippocampus; Immunosuppressive Agents; | 2017 |
Rebaudioside A inhibits pentylenetetrazol-induced convulsions in rats.
Topics: Action Potentials; Animals; Diterpenes, Kaurane; Electroencephalography; Male; Pentylenetetrazole; R | 2016 |
A microdialysis and enzymatic reactor sensing procedure for the simultaneous registration of online glutamate measurements at high temporal resolution during epileptiform activity.
Topics: Animals; Electroencephalography; Glutamic Acid; Hippocampus; Male; Microdialysis; Pentylenetetrazole | 2016 |
Comparative studies on the effects of clinically used anticonvulsants on the oxidative stress biomarkers in pentylenetetrazole-induced kindling model of epileptogenesis in mice.
Topics: Animals; Anticonvulsants; Biomarkers; Kindling, Neurologic; Lipid Peroxidation; Male; Mice; Nitric O | 2017 |
Structure-activity relationship for the anticonvulsant effects of organic solvents.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Exc | 2016 |
Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats.
Topics: Animals; Anticonvulsants; Apelin Receptors; Apoptosis; Astrocytes; Brain; Disease Models, Animal; Gl | 2016 |
Structural Exploration of Quinazolin-4(3H)-ones as Anticonvulsants: Rational Design, Synthesis, Pharmacological Evaluation, and Molecular Docking Studies.
Topics: Acetamides; Animals; Anticonvulsants; Computer Simulation; Dose-Response Relationship, Drug; Drug De | 2016 |
Neuroprotective mechanism of Coenzyme Q10 (CoQ10) against PTZ induced kindling and associated cognitive dysfunction: Possible role of microglia inhibition.
Topics: Animals; Cerebral Cortex; Cognitive Dysfunction; Dose-Response Relationship, Drug; Hippocampus; Infl | 2016 |
Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Apoptosis; Caspase 3; Cerebral Cortex; Cytoprote | 2017 |
Anticonvulsant activity of an active fraction extracted from Crinum jagus L. (Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models.
Topics: Animals; Anticonvulsants; Crinum; Depression; Disease Models, Animal; Kindling, Neurologic; Male; Mi | 2016 |
SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats.
Topics: Animals; Anxiety; Benzoxazoles; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Maze L | 2017 |
Chronic 5-HT
Topics: Animals; Anticonvulsants; Biguanides; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus | 2016 |
EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Cells, Cultured; Disease Models, Animal; Epilepsy | 2017 |
Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation.
Topics: Animals; Carotenoids; Cognition Disorders; Cognitive Dysfunction; Crocus; Disease Models, Animal; Do | 2017 |
Changes in vagus nerve activity associated with ictal tachycardia in pigs.
Topics: Animals; Blood Pressure; Carotid Arteries; Disease Models, Animal; Electrocardiography; Electrocorti | 2016 |
Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.
Topics: Animals; Anticonvulsants; Benzothiazoles; Calcium Channels; Cerebellum; Convulsants; Disease Models, | 2016 |
Dantrolene: A Selective Ryanodine Receptor Antagonist, Protects Against Pentylenetetrazole-Induced Seizure in Mice.
Topics: Animals; Anticonvulsants; Dantrolene; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Pentyl | 2016 |
Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for K
Topics: Animals; Anticonvulsants; Disease Models, Animal; Enzyme Activation; Hydrazones; KATP Channels; Male | 2017 |
Anticonvulsant effect of dextrometrophan on pentylenetetrazole-induced seizures in mice: Involvement of nitric oxide and N-methyl-d-aspartate receptors.
Topics: Animals; Anticonvulsants; Dextromethorphan; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exc | 2016 |
Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis.
Topics: Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Huma | 2016 |
Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice.
Topics: Animals; Anti-Inflammatory Agents; Benzyl Alcohols; Convulsants; CREB-Binding Protein; Disease Model | 2017 |
Search for new potential anticonvulsants with anxiolytic and antidepressant properties among derivatives of 4,4-diphenylpyrrolidin-2-one.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Dose-Response Relationship, Dr | 2017 |
Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons.
Topics: Animals; Animals, Newborn; Astrocytes; Coculture Techniques; Dendrites; Disease Susceptibility; Enzy | 2016 |
Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression.
Topics: Animals; Anticonvulsants; Chemotherapy, Adjuvant; Depression; Dose-Response Relationship, Drug; Enzy | 2017 |
Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Disease Models, Animal; Dose-Response Relationship, Dru | 2017 |
Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.
Topics: Angelman Syndrome; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Disease Models, Animal; F | 2017 |
The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations.
Topics: Animals; Animals, Newborn; Brain; Cognition; Disease Models, Animal; Female; Male; Membrane Proteins | 2017 |
The effect of sertraline and 8-OH-DPAT on the PTZ_induced seizure threshold: Role of the nitrergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Convulsants; Disease Models, | 2017 |
Sumatriptan, an Antimigraine Drug, Inhibits Pentylenetetrazol-induced Seizures in NMRI Mice.
Topics: Animals; Anticonvulsants; Male; Mice; Migraine Disorders; Pentylenetetrazole; Seizures; Sumatriptan; | 2017 |
Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Apoptosis; Calcium; Caspase 3; Cel | 2017 |
Effects of oleuropein on pentylenetetrazol-induced seizures in mice: involvement of opioidergic and nitrergic systems.
Topics: Animals; Biological Products; Disease Models, Animal; Dose-Response Relationship, Drug; Iridoid Gluc | 2017 |
Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish.
Topics: Animals; Anticonvulsants; Cyclamates; Disease Models, Animal; Parabens; Pentylenetetrazole; Preserva | 2017 |
Chronic metformin treatment facilitates seizure termination.
Topics: AMP-Activated Protein Kinases; Animals; Male; Metformin; Mice; Mice, Inbred BALB C; Pentylenetetrazo | 2017 |
Bumetanide reduce the seizure susceptibility induced by pentylenetetrazol via inhibition of aberrant hippocampal neurogenesis in neonatal rats after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Bumetanide; Cell Movement; Cell Proliferation; Electroen | 2017 |
Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Mice; Pentylenetetrazole; | 2017 |
Effects of ferulic acid on oxidative stress, heat shock protein 70, connexin 43, and monoamines in the hippocampus of pentylenetetrazole-kindled rats.
Topics: Animals; Biogenic Monoamines; CA3 Region, Hippocampal; Catalase; Connexin 43; Coumaric Acids; Gene E | 2017 |
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Mice; Motor Ac | 2017 |
Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure.
Topics: Animals; Antioxidants; Brain; Brain Injuries; Disease Models, Animal; Epilepsy; Ghrelin; Glutathione | 2017 |
Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Disease Models, Animal; Epilepsy; Motor Activity; Pen | 2017 |
Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats.
Topics: 4-Aminopyridine; Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Blood Glucose; Die | 2017 |
Synergistic anticonvulsant effects of pregabalin and amlodipine on acute seizure model of epilepsy in mice.
Topics: Amlodipine; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combinat | 2017 |
The effects of soy and tamoxifen on apoptosis in the hippocampus and dentate gyrus in a pentylenetetrazole-induced seizure model of ovariectomized rats.
Topics: Animals; Apoptosis; Dentate Gyrus; Female; Glycine max; Hippocampus; Ovariectomy; Pentylenetetrazole | 2018 |
Mouth breathing increases the pentylenetetrazole-induced seizure threshold in mice: a role for ATP-sensitive potassium channels.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Animals; Brain; Carbon Dioxide; Diazoxide; Dose-Respon | 2008 |
Changes in the concentration of amino acids in the hippocampus of pentylenetetrazole-kindled rats.
Topics: Amino Acids; Animals; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wista | 2008 |
Seizure termination by acidosis depends on ASIC1a.
Topics: Acid Sensing Ion Channels; Acidosis; Analysis of Variance; Animals; Animals, Newborn; Behavior, Anim | 2008 |
Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anticonvulsants; Blotting, Western; | 2008 |
Synthesis of DL-fluorobenzenamides as anticonvulsants.
Topics: Animals; Anticonvulsants; Benzamides; Convulsants; Indicators and Reagents; Male; Mice; Pentylenetet | 2008 |
The inhibitory effect of trimethylamine on the anticonvulsant activities of quinine in the pentylenetetrazole model in rats.
Topics: Animals; Anticonvulsants; Convulsants; Gap Junctions; Injections, Intraventricular; Male; Methylamin | 2008 |
Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, D | 2008 |
Influence of sex on the interaction between dizocilpine (MK-801) pretreatment and acute cold-restraint stress in epilepsy susceptibility in an animal study.
Topics: Animals; Cold Temperature; Dizocilpine Maleate; Epilepsies, Myoclonic; Female; Male; Mice; Mice, Inb | 2008 |
Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response | 2008 |
Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Central Nervous System Depressants; Data Interpr | 2008 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Cr | 2008 |
Anticonvulsant activity of some xanthone derivatives.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Mice; Molecular Structure; | 2008 |
Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats.
Topics: alpha-Linolenic Acid; Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug | 2009 |
Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.
Topics: Analysis of Variance; Animals; Biophysics; Cell Count; Electric Stimulation; gamma-Aminobutyric Acid | 2009 |
Anticonvulsant serotonergic and deep brain stimulation in anterior thalamus.
Topics: Analysis of Variance; Animals; Deep Brain Stimulation; Disease Models, Animal; Dose-Response Relatio | 2009 |
Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2008 |
Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling).
Topics: Animals; Cerebral Cortex; Chlorides; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; GA | 2007 |
Tramadol-induced seizurogenic effect: a possible role of opioid-dependent gamma-aminobutyric acid inhibitory pathway.
Topics: Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; GABA Agents; Gabapentin; gamma-Ami | 2008 |
Role of nitric oxide in the anticonvulsive effect of progesterone.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Rela | 2008 |
Effect of metal chelating agents on pentylenetetrazole-induced seizure threshold in cholestatic mice.
Topics: Animals; Bile Ducts; Chelating Agents; Cholestasis; Disease Models, Animal; Dithizone; Ditiocarb; Do | 2009 |
Beneficial effects of ceftriaxone against pentylenetetrazole-evoked convulsions.
Topics: Animals; Ceftriaxone; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Pen | 2008 |
Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Disease Mode | 2008 |
Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.
Topics: Amino Acid Motifs; Animals; Behavior, Animal; Brain; Carrier Proteins; Cell Cycle Proteins; Cells, C | 2008 |
Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels.
Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Animals, Newborn; Cells, Cultured; | 2008 |
Alcohol-induced retrograde memory impairment in rats: prevention by caffeine.
Topics: Adenosine A2 Receptor Antagonists; Amnesia, Retrograde; Animals; Caffeine; Central Nervous System De | 2008 |
Amphiphysin I phosphorylation on residue threonine 260 in a pentylenetetrazole-induced seizure model.
Topics: Animals; GABA Antagonists; Hippocampus; MAP Kinase Kinase 4; Mice; Nerve Tissue Proteins; Pentylenet | 2008 |
Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; Epilepsy, | 2009 |
Antiepileptic effects of quinine in the pentylenetetrazole model of seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Moto | 2009 |
Effect of acute and chronic photoperiod modulation on pentylenetetrazole-induced clonic seizure threshold in mice.
Topics: Animals; Circadian Rhythm; Disease Susceptibility; Male; Melatonin; Mice; Pentylenetetrazole; Photop | 2008 |
Distinct patterns of electrical stimulation of the basolateral amygdala influence pentylenetetrazole seizure outcome.
Topics: Amygdala; Animals; Convulsants; Electric Stimulation; Epilepsy, Tonic-Clonic; Male; Pentylenetetrazo | 2009 |
Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Cardiovascular System; Central Nervous S | 2009 |
Possible role of GABAA-benzodiazepine receptor in anticonvulsant effects of Pasipay in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Male; Passiflora; Pentylenetet | 2008 |
Effect of oleamide on pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Hypnotics and Sedatives; Oleic Acids; Pentylenetetrazole; Rats; Seizures | 2008 |
Time course of changes in the concentration of kynurenic acid in the brain of pentylenetetrazol-kindled rats.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Kindling, Neurologic; Kynurenic Acid; Male; Pe | 2009 |
A few facts from the history of selected biological treatment methods in psychiatry.
Topics: Atropine; Clinical Trials as Topic; Coma; Convulsants; Convulsive Therapy; History, 20th Century; Hu | 2008 |
Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Disease Suscept | 2009 |
Anticonvulsant effects of the BK-channel antagonist paxilline.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dose-Response R | 2009 |
Swimming training prevents pentylenetetrazol-induced inhibition of Na+, K+-ATPase activity, seizures, and oxidative stress.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Catalase; Disease Models, Animal; Elec | 2009 |
Proconvulsant effect of khat (Catha edulis) in Sprague dawley rats.
Topics: Animals; Anticonvulsants; Catha; Central Nervous System Stimulants; Cerebral Cortex; Convulsants; Ma | 2009 |
Pharmacological screening of Malian medicinal plants used against epilepsy and convulsions.
Topics: Animals; Anticonvulsants; Epilepsy; GABA-A Receptor Agonists; In Vitro Techniques; Male; Mali; Mice; | 2009 |
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Res | 2009 |
Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia.
Topics: Animals; Ataxia; Biguanides; Drug Synergism; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Male | 2008 |
Anticonvulsant properties of saponins from Ficus platyphylla stem bark.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Cells, Cultured; Electroshock; Female; Ficus; Male | 2009 |
[The birth of biological therapy in Hungary: the story of László Meduna's first patient receiving convulsive therapy].
Topics: Biological Psychiatry; Camphor; Convulsants; Drug Administration Schedule; History, 20th Century; Hu | 2008 |
AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Benzhydryl Compounds; Disease Models, Animal; Dose-Res | 2008 |
Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase.
Topics: Animals; Convulsants; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2009 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug I | 2009 |
Synthesis of 2-substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzoxazoles; Carbamazepine; Disease Models, Animal; Ele | 2009 |
Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.
Topics: Analysis of Variance; Animals; Animals, Inbred Strains; Anticonvulsants; Arachidonic Acids; Arginine | 2009 |
Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Epilepsy, Generalized; Lethal Dose 50; Male; Met | 2008 |
Selective reorganization of GABAergic transmission in neonatal ventral hippocampal-lesioned rats.
Topics: Acoustic Stimulation; Action Potentials; Animals; Animals, Newborn; Apomorphine; Calbindin 2; Calbin | 2009 |
Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Cinnamates; Electroshock; Isoniazid; Mice; Penty | 2009 |
Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Hippocampus; Kindling, Neurologic; Ligands; | 2009 |
Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene.
Topics: Animals; Anticonvulsants; Electroshock; Hydrazones; Male; Mice; Pentylenetetrazole; Rotarod Performa | 2009 |
[Seizure activity in the EEG of rats sensitive and resistant to pentylenetetrazol kindling].
Topics: Animals; Convulsants; Electroencephalography; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2009 |
Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Administrati | 2009 |
KChIP1: a potential modulator to GABAergic system.
Topics: Animals; Brain; Female; GABA Antagonists; Gene Expression Profiling; Genetic Predisposition to Disea | 2009 |
Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.
Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Biotinylation; Bra | 2009 |
Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; Drug Inter | 2009 |
Additive anticonvulsant effects of creatine supplementation and physical exercise against pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Convulsants; Creatine; Male; Oxidative Stress; Pentylenetetrazole; Physica | 2009 |
5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: role of dorsal raphe nucleus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; GABA Antagonists; | 2009 |
[The birth of convulsive therapy].
Topics: Biological Psychiatry; Brain; Camphor; Convulsants; Convulsive Therapy; Electroconvulsive Therapy; H | 2008 |
Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pentylenetetrazole; Picr | 2009 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2009 |
Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures.
Topics: Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Female; Fever; Male; Pentylenetetraz | 2009 |
Sedative and anticonvulsant effects of an alcoholic extract of Capparis decidua.
Topics: Animals; Anticonvulsants; Capparis; Central Nervous System; Electroshock; Hypnotics and Sedatives; M | 2009 |
Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Capillary Permeability; Endothelium; Fluoresce | 2009 |
Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Diazepam; Dizocilpine Maleate; Dose-Response Relation | 2009 |
Adenosine A2A receptor deficient mice are partially resistant to limbic seizures.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Mic | 2009 |
Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Central Nervous System Stimu | 2009 |
Topiramate and vitamin e modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Electroencephalography; Fructose; Glutathione; Lipid Pe | 2009 |
A new class of anticonvulsants possessing 6 Hz activity: 3,4-dialkyloxy thiophene bishydrazones.
Topics: Animals; Anticonvulsants; Electroshock; Hydrazones; Male; Mice; Molecular Structure; Motor Activity; | 2009 |
Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice.
Topics: Analysis of Variance; Animals; Convulsants; Guanidines; Male; Mice; Nitric Oxide Synthase Type II; P | 2009 |
Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity.
Topics: Animals; Anticonvulsants; Antioxidants; Catalase; Cyclohexane Monoterpenes; Dose-Response Relationsh | 2009 |
Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cameroon; Convulsants; Diazepam; Dose-Respon | 2009 |
Synthesis of novel 2,5-disubstituted 1,3,4-thiadiazoles for their potential anticonvulsant activity: pharmacophoric model studies.
Topics: Animals; Anticonvulsants; Binding Sites; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Mol | 2009 |
Benzothiazole incorporated barbituric acid derivatives: synthesis and anticonvulsant screening.
Topics: Aniline Compounds; Animals; Anticonvulsants; Barbiturates; Benzothiazoles; Binding Sites; Drug Evalu | 2009 |
Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory.
Topics: Animals; Convulsants; Fear; Male; Maze Learning; Memory; Pentylenetetrazole; Rats; Rats, Sprague-Daw | 2009 |
Acceleration of pentylenetetrazol seizure kindling associated with induction of sensitized visual responses evoked by strobe stimulation.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes, Implanted; Kindling, Neurologic; Male; Mot | 2009 |
Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction.
Topics: Animals; Anticonvulsants; Astragalus Plant; Brain; Electric Stimulation; Electron Spin Resonance Spe | 2010 |
The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) N.E. Brown chemotypes.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fl | 2009 |
The interaction of sildenafil with the anticonvulsant effect of diazepam.
Topics: Animals; Anticonvulsants; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; | 2009 |
Complete brain-type creatine kinase deficiency in mice blocks seizure activity and affects intracellular calcium kinetics.
Topics: Animals; Behavior, Animal; Brain; Calcium; Creatine Kinase; Creatine Kinase, BB Form; Creatine Kinas | 2010 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug T | 2009 |
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2010 |
Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Male; Mice; Molecula | 2009 |
Ayurvedic processed seeds of nux-vomica: neuropharmacological and chemical evaluation.
Topics: Aloe; Animals; Behavior, Animal; Catalepsy; Central Nervous System Agents; Diazepam; Dietary Fats; F | 2010 |
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Brain Mapping; Caspase 3; Cell Death; Cer | 2009 |
Mapping of c-Fos expression in the rat brain during the evolution of pentylenetetrazol-kindled seizures.
Topics: Analysis of Variance; Animals; Brain; Brain Mapping; Disease Models, Animal; Gene Expression Regulat | 2009 |
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.
Topics: Animals; Animals, Newborn; Aspartic Acid; Biophysics; Disease Models, Animal; Electric Stimulation; | 2009 |
A revised Racine's scale for PTZ-induced seizures in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Male; Motor Activity; Pen | 2009 |
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.
Topics: Aldicarb; Animals; Biological Transport; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Ce | 2009 |
Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model.
Topics: Animals; Brain; Catalase; Colitis; Colon; Disease Models, Animal; Female; Glutathione Peroxidase; Li | 2009 |
Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction.
Topics: Animals; Anxiety Disorders; Body Temperature Regulation; Copper; Diet; Dietary Supplements; Female; | 2010 |
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential T | 2009 |
Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Brain; Cerebrovasc | 2009 |
Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Calcium; Cluster Analysis; Hippocampus; | 2010 |
Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; A | 2010 |
The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo study.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Enzyme Inhibitors; | 2009 |
Antiseizure effects of 3alpha-androstanediol and/or 17beta-estradiol may involve actions at estrogen receptor beta.
Topics: Analysis of Variance; Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Disease | 2009 |
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rat | 2009 |
Involvement of Na+/Ca2+ exchanger in pentylenetetrazol-induced convulsion by use of Na+/Ca2+ exchanger knockout mice.
Topics: Animals; Convulsants; Mice; Mice, Knockout; Pentylenetetrazole; Seizures; Sodium-Calcium Exchanger | 2009 |
[Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil].
Topics: Administration, Oral; Animals; Carbapenems; Cilastatin; Cilastatin, Imipenem Drug Combination; Dose- | 2009 |
Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Apnea; Bronchodilator Agents; Child; Convulsants; Diazepam; | 2009 |
Specificity of action of epileptogenic agents in diazepam-tolerant rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Excitatory Amino Acid Agonists; Kai | 2009 |
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; F | 2010 |
Effect of various antiepileptic drugs in a pentylenetetrazol-induced seizure model in mice.
Topics: Adenosine; Algorithms; Animals; Anti-Inflammatory Agents; Anticonvulsants; Barbiturates; Carbamazepi | 2009 |
Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain.
Topics: Animals; Brain; Convulsants; Discriminant Analysis; Least-Squares Analysis; Magnetic Resonance Spect | 2010 |
Zolpidem is a potent anticonvulsant in adult and aged mice.
Topics: Age Factors; Aging; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interact | 2010 |
Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide.
Topics: Animals; Anticonvulsants; Arginine; Disease Models, Animal; Disease Susceptibility; Dose-Response Re | 2010 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; | 2010 |
Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Catalase; Cognition; Cognition D | 2010 |
ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cromakalim; Diabetes Mellitus, Experiment | 2010 |
Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.
Topics: Animals; Cerebral Cortex; Convulsants; Crosses, Genetic; Disease Models, Animal; Dizocilpine Maleate | 2010 |
Anticonvulsant and neurotoxicity evaluation of some N(4) phenyl substituted pyridyl semicarbazones.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinica | 2009 |
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus | 2010 |
Palmitone prevents pentylenetetrazole-caused neuronal damage in the CA3 hippocampal region of prepubertal rats.
Topics: Aging; Animals; CA3 Region, Hippocampal; Cell Count; Convulsants; Hydrocarbons; Ketones; Neurons; Ne | 2010 |
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Endothelin-1; Gait Disorders, Neurologic; Glut | 2009 |
Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Avoidance Learning; Behavior, Ani | 2010 |
Anticonvulsant and neurotoxicity evaluation of some novel kojic acids and allomaltol derivatives.
Topics: Animals; Anticonvulsants; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Evaluati | 2010 |
[Drugs and the mechanism for reversing the tolerance of flurazepan in rats].
Topics: Animals; Anticonvulsants; Drug Tolerance; Flurazepam; Hippocampus; Male; Neuropeptide Y; Pentylenete | 2010 |
Mossy fiber sprouting, hippocampal damage and spontaneous recurrent seizures in pentylenetetrazole kindling rat model.
Topics: Animals; Electroencephalography; Hippocampus; Kindling, Neurologic; Male; Mossy Fibers, Hippocampal; | 2009 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre | 2010 |
Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2010 |
Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission.
Topics: Acetylcholine; Acetylcholinesterase; Analysis of Variance; Animals; Anticonvulsants; Brain; Centella | 2010 |
Convulsive activity in the electroencephalogram in rats sensitive and tolerant to pentylenetetrazol kindling.
Topics: Animals; Convulsants; Electroencephalography; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2010 |
Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose- | 2010 |
Effects of antiepileptics on behavioral and electroencephalographic seizure induced by pentetrazol in mice.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Ele | 2010 |
Synthesis and anticonvulsant activity of new kojic acid derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Indicators and Reagents; Magnetic Resonance Spe | 2010 |
Increased hippocampal T2 in a rat model of pentylenetetrazol-induced kindling correlates with seizure scores.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Glial Fibrillary Acidic Protein; | 2010 |
Respective indications of cures by insulin, cardiazolic and electric shocks.
Topics: Insulin; Mental Disorders; Pentylenetetrazole; Psychotic Disorders; Schizophrenia; Seizures; Therape | 1946 |
Respective indications of insulin therapy, cardiazoltherapy and electrochoctherapy.
Topics: Insulin; Mental Disorders; Pentylenetetrazole; Psychotic Disorders; Schizophrenia; Seizures; Therape | 1946 |
The comparative value of pentothal sodium, curare, and magnesium sulfate for the modification of metrazol convulsions.
Topics: Anesthesia; Anesthesiology; Barbital; Curare; Magnesium; Magnesium Sulfate; Pentylenetetrazole; Seiz | 1946 |
Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclic GMP; Disease Models, Animal; Dose-Response R | 2010 |
Oxygen consumption of the cerebral cortex during metrazol convulsions in cats.
Topics: Animals; Brain; Cats; Cerebral Cortex; Oxygen; Oxygen Consumption; Pentylenetetrazole; Seizures | 1947 |
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Gl | 2010 |
Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method.
Topics: Animals; Anticonvulsants; Anxiety; Dose-Response Relationship, Drug; Flavonoids; GABA Agonists; gamm | 2010 |
Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Gen | 2010 |
Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice.
Topics: Animals; Anticonvulsants; Brain; Excitatory Amino Acid Antagonists; GABA Agents; Indans; Kindling, N | 2010 |
Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures.
Topics: Acoustic Stimulation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Convulsants; Down | 2010 |
Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide.
Topics: Anilides; Animals; Anticonvulsants; Convulsants; Electroshock; Mice; Neural Tube Defects; Pentylenet | 2010 |
Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid; Dis | 2010 |
The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Kindling, Neurologic; Male; Pentylenetetrazole; R | 2010 |
Acquisition of an active avoidance reaction in rats and morphological changes in the hippocampus in pentylenetetrazol kindling.
Topics: Animals; Avoidance Learning; GABA Antagonists; Hippocampus; Kindling, Neurologic; Male; Neurons; Pen | 2010 |
Potential roles of Cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model.
Topics: Animals; Cyclin-Dependent Kinase 5; Disease Progression; Epilepsy, Temporal Lobe; Hippocampus; Immun | 2010 |
Seizure tests distinguish intermittent fasting from the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Anticonvulsants; Blood Glucose; Caloric Restri | 2010 |
Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives.
Topics: Animals; Anticonvulsants; Benzopyrans; Electroshock; Indicators and Reagents; Lethal Dose 50; Male; | 2010 |
Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Anticonvulsants; Antimetabolites; Blood Glucos | 2010 |
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Do | 2010 |
Stress within the postseizure time window inhibits seizure recurrence.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Anticonvulsants; Circadian Rhythm; Corticos | 2010 |
Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.
Topics: Analgesics; Animals; Anti-Infective Agents; Anticonvulsants; Antineoplastic Agents; Bacteria; Cell L | 2010 |
[EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures].
Topics: Animals; Antioxidants; Ataxia; Behavior, Animal; Corpus Callosum; Excitatory Amino Acid Agonists; GA | 2010 |
Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.
Topics: Animals; Base Sequence; Carrier Proteins; Cells, Cultured; Convulsants; DNA Primers; Genes, p53; Hum | 2010 |
Modeling seizure-related behavioral and endocrine phenotypes in adult zebrafish.
Topics: Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fema | 2010 |
Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Carbolines; Disease Models, Animal; Electroshock; Kain | 2010 |
N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: synthesis and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Hydrazin | 2010 |
Design & synthesis of 2-(substituted aryloxy)-5-(substituted benzylidene)-3-phenyl-2,5-dihydro-1H-[1,2,4] triazin-6-one as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Design; Electroshock; Male; Mice; Nervous System; P | 2010 |
An experimental study of the anticonvulsant effect of amlodipine in mice.
Topics: Amlodipine; Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Disease Models, Animal; | 2010 |
Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice.
Topics: Animals; Anticonvulsants; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Pioglitazone; PPAR g | 2010 |
Improvement of pentylenetetrazol-induced learning deficits by valproic acid in the adult zebrafish.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Dose-Response Relationship, D | 2010 |
Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Do | 2010 |
The differential effects of protein synthesis inhibition on the expression and reconsolidation of pentylenetetrazole kindled seizures.
Topics: Animals; Cycloheximide; Disease Models, Animal; Drug Interactions; Exploratory Behavior; Fear; Gene | 2010 |
Anticonvulsant activity of embelin isolated from Embelia ribes.
Topics: Animals; Anticonvulsants; Benzoquinones; Central Nervous System Depressants; Diazepam; Dose-Response | 2011 |
Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents.
Topics: Animals; Anticonvulsants; Bignoniaceae; Electroshock; Mice; Nigeria; Pentylenetetrazole; Phytotherap | 2009 |
Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2010 |
Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins.
Topics: Animals; Anticonvulsants; Electroshock; Hydantoins; Male; Mannich Bases; Mice; Pentylenetetrazole; R | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species.
Topics: Animals; Anticonvulsants; Artemia; Convulsants; Ferula; Iran; Lethal Dose 50; Male; Medicine, Tradit | 2010 |
Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats.
Topics: Anesthetics, Inhalation; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Apomor | 2010 |
Inhibition of NMDA receptor/NO signaling blocked tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; NG | 2010 |
Epileptogenic insult alters endogenous adenosine control on long-term changes in synaptic strength by theta pattern stimulation in hippocampus area CA1.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Convulsants; Epilepsy; Excitatory Postsynapti | 2011 |
Effect of short-term lead exposure on PTZ-induced seizure threshold in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Drug Inter | 2010 |
Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.
Topics: Action Potentials; Animals; Cell Line; Cells, Cultured; Convulsants; Epilepsy; Ether-A-Go-Go Potassi | 2010 |
Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures.
Topics: Animals; Disease Models, Animal; Kaplan-Meier Estimate; Mice; Mice, Inbred C57BL; Mice, Knockout; N- | 2010 |
Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats.
Topics: Acetylcholinesterase; Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease | 2010 |
Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Chemistry; Cognition Disorders; Convulsants; Drug Eval | 2010 |
Intranasal clobazam delivery in the treatment of status epilepticus.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Drug Stabili | 2011 |
Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Chromatography, High Pressu | 2010 |
Anticonvulsant action of 2-chloroadenosine against pentetrazol-induced seizures in immature rats is due to activation of A1 adenosine receptors.
Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Convulsants; Male; Pentylenetetrazole; Rats; Rats, Wist | 2010 |
Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory.
Topics: Age Factors; Animals; Avoidance Learning; Conditioning, Classical; Convulsants; Crosses, Genetic; Cy | 2011 |
Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically-induced seizures.
Topics: Animals; Anticonvulsants; Brain; Cattle; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Human | 2010 |
Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors.
Topics: Animals; Behavior, Animal; Connexins; Convulsants; DNA, Complementary; Female; Gap Junction delta-2 | 2010 |
Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model.
Topics: Administration, Oral; Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition Disorder | 2010 |
Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures.
Topics: Animals; Anticonvulsants; Arginase; Behavior, Animal; Biogenic Polyamines; Brain; Convulsants; Male; | 2010 |
Effect of pentylenetetrazole and sound stimulation induced single and repeated convulsive seizures on the MDA, GSH and NO levels, and SOD activities in rat liver and kidney tissues.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Convulsants; Disease Models, Animal; Glutathion | 2010 |
Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Rela | 2010 |
The effects of atorvastatin on memory deficit and seizure susceptibility in pentylentetrazole-kindled rats.
Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Atorvastatin; Avoidance Learning; Disease S | 2010 |
Anticonvulsant effect of (E)-2-benzylidene-4-phenyl-1,3-diselenole in a pilocarpine model in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Antioxidants; Brain; Disease Models, Animal; Dose-Respons | 2010 |
Administration of lithium and magnesium chloride inhibited tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; | 2010 |
Seizure-induced changes in neuropeptide Y-containing cortical neurons: Potential role for seizure threshold and epileptogenesis.
Topics: Animals; Cell Count; Cerebral Cortex; Disease Models, Animal; Electroshock; Gene Expression Regulati | 2010 |
Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice.
Topics: Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Ketones; Male; | 2011 |
Minimal electroencephalographic response to metrazol as a method for measuring the convulsive threshold for use in human beings.
Topics: Brain; Electroencephalography; Mental Disorders; Pentylenetetrazole; Psychotic Disorders; Seizures; | 1946 |
Anticonvulsant action of drugs against metrazol and anti-epileptic activity.
Topics: Anticonvulsants; Epilepsy; Pentylenetetrazole; Seizures | 1946 |
Studies in insulin and metrazol therapy; differential effects on some psychological functions.
Topics: Humans; Insulin; Mental Disorders; Pentylenetetrazole; Seizures; Therapeutics | 1945 |
Distinct temporal patterns of electrical stimulation influence neural recruitment during PTZ infusion: an fMRI study.
Topics: Amygdala; Animals; Brain Mapping; Electric Stimulation; Electroencephalography; Epilepsy; Humans; Ma | 2011 |
Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure.
Topics: Animals; Electroencephalography; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetraz | 2011 |
Anticonvulsant activities of myo-inositol and scyllo-inositol on pentylenetetrazol induced seizures.
Topics: Animals; Anticonvulsants; Convulsants; Inositol; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2011 |
The anticonvulsant effects of propofol and a propofol analog, 2,6-diisopropyl-4-(1-hydroxy-2,2,2-trifluoroethyl)phenol, in a 6 Hz partial seizure model.
Topics: Animals; Anticonvulsants; Ataxia; Disease Models, Animal; Dose-Response Relationship, Drug; Electric | 2011 |
A single episode of neonatal seizures alters the cerebellum of immature rats.
Topics: Animals; Animals, Newborn; Autoradiography; Calbindins; Cell Count; Cell Proliferation; Cerebellum; | 2011 |
Synthesis and anticonvulsant activity of some alkanamide derivatives.
Topics: Alkanes; Amides; Animals; Anticonvulsants; Convulsants; Electroshock; Indicators and Reagents; Magne | 2010 |
Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Clonazepam; Disease Susceptibility; GABA Modulators | 2011 |
Differential molecular regulation of glutamate in kindling resistant rats.
Topics: Animals; Convulsants; DNA Primers; Electric Stimulation; Epilepsy, Tonic-Clonic; Glutamic Acid; Hipp | 2011 |
Chemical composition and biological activities of Calamintha officinalis Moench essential oil.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Antifungal Agents; Artemia; Behavior, Animal; Body | 2011 |
Design & synthesis of N'-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents.
Topics: Algorithms; Animals; Anticonvulsants; Cell Death; Computer Simulation; Dose-Response Relationship, D | 2011 |
Prevention of sodium valproate-induced hepatotoxicity by curcumin, rosiglitazone and N-acetylcysteine in rats.
Topics: Acetylcysteine; Animals; Anticonvulsants; Body Weight; Chemical and Drug Induced Liver Injury; Convu | 2010 |
Imidazolylchromanone oxime ethers as potential anticonvulsant agents: Anticonvulsive evaluation in PTZ-kindling model of epilepsy and SAR study.
Topics: Animals; Anticonvulsants; Benzopyrans; Epilepsy; Humans; Kindling, Neurologic; Oximes; Pentylenetetr | 2011 |
Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cell Death; Convulsants; Cyclooxygenase 2; Cyclooxygenas | 2011 |
Menthone aryl acid hydrazones: a new class of anticonvulsants.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Hydrazones; Injections, In | 2011 |
Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Convulsants; Dise | 2011 |
Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Catalase; Cognition Disorders; Disease Models, Animal; Drug | 2011 |
A novel series of 2,5-disubstituted 1,3,4-oxadiazoles: synthesis and SAR study for their anticonvulsant activity.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2011 |
Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats.
Topics: Animals; Benzothiadiazines; Convulsants; Electrophysiology; Excitatory Postsynaptic Potentials; Hipp | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Respons | 2011 |
Synthesis and screening of substituted thiosemicarbazone derivatives: an approach towards novel anticonvulsant search.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Humans; Mice; Molecular Structure; Pentylenetet | 2011 |
A role for opioid system in the proconvulsant effects of sildenafil on the pentylenetetrazole-induced clonic seizure in mice.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Morphine; | 2011 |
Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice.
Topics: Animals; Anti-Anxiety Agents; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response | 2011 |
Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: role of nitric oxide and μ receptors.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mice; Mo | 2011 |
Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides μ1 receptor-mediated post-ictal antinociception.
Topics: Analgesia; Animals; Dendrimers; Drug Carriers; Male; Naloxone; Narcotic Antagonists; Pentylenetetraz | 2011 |
Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2011 |
Convulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structures.
Topics: Animals; Anticonvulsants; Chlorides; Drug Evaluation, Preclinical; Electroshock; Flavones; Hydroxide | 2011 |
Detection of nonlinear interactions of EEG alpha waves in the brain by a new coherence measure and its application to epilepsy and anti-epileptic drug therapy.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Convulsants; Electroencephalography; Epilepsy; Ethosuximi | 2011 |
Transcutaneous focal electrical stimulation via concentric ring electrodes reduces synchrony induced by pentylenetetrazole in beta and gamma bands in rats.
Topics: Animals; Brain; Electrodes; Electroencephalography; Humans; Male; Pentylenetetrazole; Rats; Rats, Sp | 2011 |
Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.
Topics: Animals; Anticonvulsants; Convulsants; Crosses, Genetic; Dose-Response Relationship, Drug; Electrosh | 2011 |
Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats.
Topics: Animals; Behavior, Animal; Convulsants; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Lea | 2011 |
Excitation-inhibition balance in the CA3 network--neuronal specificity and activity-dependent plasticity.
Topics: Animals; CA3 Region, Hippocampal; Convulsants; Electric Stimulation; Electrophysiology; Excitatory A | 2011 |
Modulation of anticonvulsant effects of cannabinoid compounds by GABA-A receptor agonist in acute pentylenetetrazole model of seizure in rat.
Topics: Animals; Anticonvulsants; Benzamides; Benzoxazines; Biphenyl Compounds; Brain; Calcium Channel Block | 2011 |
The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Biguanides; Citalopram; Disease Models, Animal; Dose | 2011 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pent | 2011 |
Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures.
Topics: Animals; Cystinyl Aminopeptidase; Gene Deletion; Genetic Predisposition to Disease; Male; Mice; Mice | 2011 |
The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Inj | 2011 |
Synthesis, in silico metabolic and toxicity prediction of some novel imidazolinones derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Convulsants; Imidazolines; Mice; Molecular Structure; Pentylenetetrazole; | 2012 |
Clavulanic acid does not affect convulsions in acute seizure tests in mice.
Topics: Analysis of Variance; Animals; Clavulanic Acid; Convulsants; Disease Models, Animal; Electroshock; E | 2012 |
Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Convulsants; Electroshock; Formaldehyde; Male; Mi | 2011 |
Additive anticonvulsant effects of agmatine and lithium chloride on pentylenetetrazole-induced clonic seizure in mice: involvement of α₂-adrenoceptor.
Topics: Agmatine; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Lithium Chlori | 2011 |
Effects of soy extract on pentylenetetrazol-induced seizures in ovariectomized rats.
Topics: Animals; Female; Glycine max; Ovariectomy; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; S | 2011 |
Can propofol cause seizures? an experimental study.
Topics: Animals; Apoptosis; Convulsants; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationsh | 2011 |
The involvement of Na+, K+-ATPase activity and free radical generation in the susceptibility to pentylenetetrazol-induced seizures after experimental traumatic brain injury.
Topics: Animals; Brain Injuries; Enzyme Activation; Free Radicals; Male; Pentylenetetrazole; Rats; Rats, Wis | 2011 |
Closed-loop seizure control on epileptic rat models.
Topics: Animals; Artificial Intelligence; Brain; Convulsants; Disease Models, Animal; Electric Impedance; El | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cl | 2011 |
Anticonvulsant, antidepressant-like activity of Abelmoschus manihot ethanol extract and its potential active components in vivo.
Topics: Abelmoschus; Animals; Anticonvulsants; Antidepressive Agents; Brain; Chromatography, Liquid; Drug Ev | 2011 |
Antidepressant effect and pharmacological evaluation of standardized extract of flavonoids from Byrsonima crassifolia.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Antidepressive Agents; Chromatography, High Pres | 2011 |
Spadin as a new antidepressant: absence of TREK-1-related side effects.
Topics: Animals; Antidepressive Agents; Biophysical Phenomena; Blood Glucose; Brain Infarction; CD8 Antigens | 2012 |
Paradoxical effect of noradrenaline-mediated neurotransmission in the antinociceptive phenomenon that accompanies tonic-clonic seizures: role of locus coeruleus neurons and α(2)- and β-noradrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Neurons; Animals; Disease Models, Animal; Dose-R | 2011 |
Synthesis and anticonvulsant evaluation of some novel (thio)semicarbazone derivatives of arylalkylimidazole.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Imidazoles; Indicators and Reagents; Magnetic R | 2011 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rela | 2011 |
Anticonvulsant and depressant effects of aqueous extracts of Carum copticum seeds in male rats.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Carum; Disease Models, Animal; Dose-Respon | 2011 |
Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Gene Expression; Heme Oxygenase-1; Hippocam | 2012 |
Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Interleukin-1beta; Kainic Acid; Lactones; Mice | 2012 |
Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines.
Topics: Animals; Anticonvulsants; Diketopiperazines; Electroshock; Epilepsy; Humans; Male; Mice; Models, Mol | 2011 |
Khat (Catha edulis) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model.
Topics: Alcoholism; Animals; Catha; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism | 2011 |
Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones.
Topics: Administration, Oral; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Drug | 2011 |
[Sedative, hypnotic and anticonvulsive effects of an adenosine analogue WS090501].
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anticonvul | 2011 |
Synthesis and biological evaluation of some novel quinoxaline derivatives as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Indicators and Reagents; Ma | 2011 |
Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.
Topics: Animals; Anticonvulsants; Blotting, Western; Brain-Derived Neurotrophic Factor; Convulsants; Diazepa | 2011 |
Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Atorvastatin; Blood-Brain Barrier; Cerebral Cortex; Cholesterol; Convulsan | 2011 |
An early decrease in cell proliferation after pentylenetetrazole-induced seizures.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Disease Models, Animal; Dos | 2011 |
PTZ-induced seizures inhibit adenosine deamination in adult zebrafish brain membranes.
Topics: Adenosine; Adenosine Deaminase; Animals; Brain; Convulsants; Deamination; Pentylenetetrazole; Pyroph | 2011 |
Glutamate decarboxylase and GABA aminotransferase levels in different regions of rat brain on the onset of Leptazol induced convulsions.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Glutamate Decarboxylase; Male; Pentylenetetrazole; Rat | 2012 |
Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice.
Topics: Animals; Bucladesine; Dose-Response Relationship, Drug; Drug Interactions; Isoquinolines; Male; Mice | 2011 |
Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid.
Topics: Amides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Female; Isomeri | 2011 |
Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Antidepressive Agents; Behavior, Anima | 2011 |
Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues.
Topics: Animals; Anticonvulsants; Azepines; Chemistry Techniques, Synthetic; Hydrophobic and Hydrophilic Int | 2011 |
Synthesis and anticonvulsant activity of some 2-(2-{1-[substituted phenyl]ethylidene}hydrazinyl)-4-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyrimidine-5-carbonitrile.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Convulsants; Disease | 2012 |
Design, synthesis and screening of quinoline-incorporated thiadiazole as a potential anticonvulsant.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Design; Male; Mice; Pentyle | 2012 |
Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Avoidance Learning; Brain; Butyrylcholinesteras | 2012 |
Design, synthesis and evaluation of anticonvulsant activity of pyridinyl-pyrrolidones: a pharmacophore hybrid approach.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Fe | 2012 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani | 2012 |
Effects of different extracts of Rosa damascena on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Drug Antagonism; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Plan | 2011 |
Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit.
Topics: 1-Butanol; Alcohol Drinking; Alcohol Withdrawal Seizures; Amino Acid Substitution; Animals; Behavior | 2012 |
Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice.
Topics: Animals; Anticonvulsants; Biological Availability; Chemistry, Pharmaceutical; Curcumin; Disease Mode | 2013 |
Regulatory role of the dopamine and norepinephrine transporters in pentylenetetrazol-kindled mice: association with effect of antidepressants.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Atomoxetine Hydrochloride; Bupropion; | 2011 |
Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior.
Topics: Amino Acid Sequence; Animals; Apoptosis; Behavior, Animal; Brain; Gene Expression Regulation, Develo | 2011 |
Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models.
Topics: Acetates; Animals; Anticonvulsants; Antioxidants; Catalase; Corpus Striatum; Disease Models, Animal; | 2011 |
The antiepileptic effect of sodium valproate during different phases of the estrous cycle in PTZ-induced seizures in rats.
Topics: Animals; Anticonvulsants; Estrous Cycle; Female; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; V | 2012 |
Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief.
Topics: Animals; Anti-Anxiety Agents; Cattle; Hyperalgesia; Male; Mice; Pain; Pentylenetetrazole; Radioligan | 2011 |
Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits μ1-opioid receptor to modulate post-ictal antinociception.
Topics: Animals; Inferior Colliculi; Male; Naloxone; Opioid Peptides; Pentylenetetrazole; Rats; Rats, Wistar | 2012 |
Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.
Topics: Animals; Atrophy; Brain; Cystatin B; Disease Models, Animal; Disease Susceptibility; Down Syndrome; | 2011 |
Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling.
Topics: Animals; Brain; Electroencephalography; Electromyography; Epilepsy; Equipment Design; Hypothermia, I | 2011 |
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Cell Line, Tumor; Convulsants; Disease Models | 2012 |
Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Oxytoci | 2012 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; | 2012 |
A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study : special issue related to kynurenine.
Topics: Action Potentials; Animals; Kynurenic Acid; Kynurenine; Male; Pentylenetetrazole; Rats; Rats, Spragu | 2012 |
Transcranial focal stimulation via concentric ring electrodes reduced power of pentylenetetrazole-induced seizure activity in rat electroencephalogram.
Topics: Animals; Brain; Electric Stimulation; Electrodes; Electroencephalography; Male; Pentylenetetrazole; | 2011 |
Algorithm for automatic detection of pentylenetetrazole-induced seizures in rats.
Topics: Algorithms; Animals; Automation; Electric Stimulation; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2011 |
Triheptanoin in acute mouse seizure models.
Topics: Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Mice; Mice, Inbred C3H; Pentylenete | 2012 |
Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine.
Topics: Acorus; Animals; Anticonvulsants; Carbamazepine; Convulsants; Dose-Response Relationship, Drug; Drug | 2012 |
Traxoprodil decreases pentylenetetrazol-induced seizures.
Topics: Animals; Male; Pentylenetetrazole; Piperidines; Rats; Rats, Wistar; Reaction Time; Receptors, N-Meth | 2012 |
Synthesis and biological evaluation of 9-alkoxy-6,7-dihydro-5H-benzo[c] [1,2,4]triazolo[4,3-a]azepines as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Azepines; Convulsants; Electroshock; Mice; Pentylenetetrazole; Postural Ba | 2012 |
Acute seizure tests in epilepsy research: electroshock- and chemical-induced convulsions in the mouse.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2009 |
Anticonvulsant activity of the essential oil and methanolic extract of Bunium persicum (Boiss). B. Fedtsch.
Topics: Animals; Anticonvulsants; Apiaceae; Electroshock; Iran; Male; Mice; Mice, Inbred Strains; Monoterpen | 2012 |
Synthesis and anticonvulsant activity of 1-(2-(8-(benzyloxy)quinolin-2-yl)-1-butyrylcyclopropyl)-3-substituted urea derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Male; Mice; Pentylenetetrazole; Quinolines; Sei | 2012 |
Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Convulsants; Drug Interactions; Drug Therapy, Combination; Male; Mice; Pen | 2012 |
Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.
Topics: Animals; Astrocytes; Bridged-Ring Compounds; Calcium-Binding Proteins; Cerebral Cortex; Convulsants; | 2012 |
Anticonvulsant action of GABAB receptor positive modulator CGP7930 in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; GABA-B Receptor Agonists; Injections, Subcutaneous; Male; Pen | 2012 |
UPLC-TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Ch | 2012 |
Evaluation of anticonvulsant and nootropic effect of ondansetron in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electroshock; Male; Mice; Nootropic Agents; Ondansetron; | 2012 |
Kynurenic acid: a new effector of valproate action?
Topics: Animals; Anticonvulsants; Hippocampus; Kindling, Neurologic; Kynurenic Acid; Male; Neurons; Pentylen | 2011 |
Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Drug Administration Routes; | 2012 |
Influence of carvedilol on anticonvulsant effect of gabapentin.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Brain; Carbazoles; Carvedilol; Convulsants; | 2011 |
Involvement of transient receptor potential vanilloid type 1 channels in the pro-convulsant effect of anandamide in pentylenetetrazole-induced seizures.
Topics: Animals; Arachidonic Acids; Convulsants; Endocannabinoids; Male; Mice; Pentylenetetrazole; Polyunsat | 2012 |
Effects of Hypericum montbretti extract on the central nervous system and involvement of GABA (A)/Benzodiazepine receptors in its pharmacological activity.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System; Diazepam; Exploratory Behavior; | 2012 |
Synthesis and anticonvulsant activity of 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Heterocyclic Compounds, 3-Ring | 2013 |
Synthesis, resolution and anticonvulsant activity of chiral N-1'-ethyl,N-3'-(1-phenylethyl)-(R,S)-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-trione diastereomers.
Topics: Animals; Anticonvulsants; Benzofurans; Humans; Imidazolidines; Mice; Pentylenetetrazole; Seizures; S | 2012 |
Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide.
Topics: Analysis of Variance; Animals; Anticonvulsants; Atorvastatin; Convulsants; Disease Models, Animal; D | 2012 |
Anticonvulsant effect of Marsilea quadrifolia Linn. on pentylenetetrazole induced seizure: a behavioral and EEG study in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Waves; Disease Models, Animal; Electroencep | 2012 |
Effects of bee products on pentylenetetrazole-induced seizures in the rat.
Topics: Animals; Bees; Honey; Kindling, Neurologic; Male; Pentylenetetrazole; Propolis; Rats; Rats, Wistar; | 2011 |
Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Cholinesterase Inhibitors; Convulsants; Dise | 2012 |
Anticonvulsive effect of atorvastatin on pentylenetetrazole-induced seizures in mice: the role of nitric oxide pathway.
Topics: Animals; Anticonvulsants; Arginine; Atorvastatin; Heptanoic Acids; Male; Mice; NG-Nitroarginine Meth | 2013 |
Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice.
Topics: Anilides; Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Enzyme | 2012 |
Docosahexaenoic acid and phosphatidylserine supplementations improve antioxidant activities and cognitive functions of the developing brain on pentylenetetrazol-induced seizure model.
Topics: Animals; Antioxidants; Brain; Catalase; Cognition; Convulsants; Dietary Supplements; Docosahexaenoic | 2012 |
Neuroprotective and anticonvulsant effects of organic and conventional purple grape juices on seizures in Wistar rats induced by pentylenetetrazole.
Topics: Animals; Male; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; Seizures; Vitis | 2012 |
Design, synthesis and in vivo/in vitro screening of novel chlorokojic acid derivatives.
Topics: Animals; Anti-Infective Agents; Anticonvulsants; Antitubercular Agents; Chemistry Techniques, Synthe | 2013 |
Role of saponins for the anticonvulsant effect of adventitious roots of Ficus religiosa.
Topics: Animals; Anticonvulsants; Ficus; Male; Mice; Pentylenetetrazole; Plant Extracts; Plant Roots; Saponi | 2012 |
Neuronal conditional knockout of NRSF decreases vulnerability to seizures induced by pentylenetetrazol in mice.
Topics: Animals; Lethal Dose 50; Male; Mice; Mice, Knockout; Pentylenetetrazole; Repressor Proteins; Seizure | 2012 |
Synthesis and anticonvulsant activity of some 2/3-benzoylaminopropionanilide derivatives.
Topics: Acetamides; Anilides; Animals; Anticonvulsants; Benzoates; Convulsants; Electroshock; Injections, Su | 2012 |
Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aster Plant; Chromatography, High Pressure Liquid; Disease Models, Animal; | 2012 |
Anticonvulsant effect of retigabine during postnatal development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Convulsants; Dose-Response Relationsh | 2012 |
Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Anticonvulsants; Chromatography, High | 2012 |
Decreased GABABR expression and increased neuronal cell death in developing rat brain after PTZ-induced seizure.
Topics: Animals; Animals, Newborn; Baclofen; Caspase 3; Cell Death; Disease Models, Animal; Electroencephalo | 2013 |
Effects of epigallocatechin-3-gallate on pentylenetetrazole-induced kindling, cognitive impairment and oxidative stress in rats.
Topics: Animals; Brain; Catechin; Cognition; Convulsants; Kindling, Neurologic; Male; Maze Learning; Neuropr | 2012 |
Quinazolino-benzothiazoles: fused pharmacophores as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Benzothiazoles; Drug Design; Electroshock; Male; Mice; Pentylenetetrazole; | 2012 |
Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats.
Topics: Animals; Anticonvulsants; Apigenin; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Neur | 2012 |
Anticonvulsant and antioxidative activity of hydroalcoholic extract of tuber of Orchis mascula in pentylenetetrazole and maximal electroshock induced seizures in rats.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Brain; Butyrylchol | 2012 |
5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide.
Topics: Animals; Anticonvulsants; Biguanides; Citalopram; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2012 |
Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Convulsants; Dextrans; Disease Models, Animal; Ele | 2012 |
[Adrenaline potentiates antiepileptic but not sedative action of diazepam in rats].
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Epinephrine; Gastric Mucosa; Hypnotics and Sedat | 2012 |
Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Drug Synergi | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agoni | 2012 |
Synthesis and anticonvulsant properties of new mannich bases derived from 3,3-disubstituted pyrrolidine-2,5-diones. Part IV.
Topics: Administration, Oral; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Elect | 2012 |
Inhibition of pentylenetetrazole-induced seizure in mice by using a 4 Hz magnetic field: a comparative study with a 60 Hz magnetic field.
Topics: Animals; Magnetic Field Therapy; Mice; Oxidative Stress; Pentylenetetrazole; Seizures | 2012 |
A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Bipolar Disorder; Dark Ada | 2012 |
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
Topics: Aging; Amyloid beta-Peptides; Animals; Apolipoprotein E4; Behavior, Animal; Biomarkers; Body Weight; | 2012 |
Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Models, A | 2012 |
The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.
Topics: Age Factors; Animals; Anti-Allergic Agents; Brain; Caffeine; Central Nervous System Stimulants; Dibe | 2012 |
Noninvasive transcranial focal stimulation via tripolar concentric ring electrodes lessens behavioral seizure activity of recurrent pentylenetetrazole administrations in rats.
Topics: Animals; Dose-Response Relationship, Drug; Electrodes; Equipment Design; Equipment Failure Analysis; | 2013 |
Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain.
Topics: Animals; Anticonvulsants; Brain; Hippocampus; Hypoxia; Long-Term Potentiation; Male; Neurons; Neurop | 2012 |
Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice.
Topics: Acetylcarnitine; Animals; Chromatography, High Pressure Liquid; Convulsants; Dietary Supplements; Gl | 2012 |
Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II.
Topics: Administration, Oral; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male | 2012 |
Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbon; Folic Acid; gamma-Aminobutyric Acid; Larva; Mode | 2012 |
Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore.
Topics: Amino Acids; Animals; Anticonvulsants; Catalytic Domain; Computer Simulation; Drug Design; Hydrogen | 2012 |
Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase.
Topics: Animals; Astrocytes; Blotting, Western; Chromatography, High Pressure Liquid; Convulsants; Electrosh | 2012 |
Decreased susceptibility to seizures induced by pentylenetetrazole in serine racemase knockout mice.
Topics: Amino Acids; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Convulsants | 2012 |
Selenium induced anticonvulsant effect: a potential role of prostaglandin E(1) receptor activation linked mechanism.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Misoprostol; Pentylenetetraz | 2013 |
Repeated PTZ treatment at 25-day intervals leads to a highly efficient accumulation of doublecortin in the dorsal hippocampus of rats.
Topics: Animals; Biomarkers; Bromodeoxyuridine; Cell Count; Cell Lineage; Disease Susceptibility; Dose-Respo | 2012 |
Influence of NG-nitro-L-arginine methyl ester on clinical and biochemical effects of methylene blue in pentylenetetrazole-evoked convulsions.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Enzyme Inhibitors; Lipid Peroxidation; Male; Methylene | 2012 |
Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Agonists; Dise | 2012 |
Synthesis and anticonvulsant activity of O-alkylated derivatives of 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime.
Topics: Alkylation; Animals; Anticonvulsants; Chloroacetates; Diazepam; Imidazoles; Male; Mice; Oximes; Pent | 2012 |
Influence of carbenoxolone on the anticonvulsant efficacy of phenytoin in pentylenetetrazole kindled rats.
Topics: Animals; Anticonvulsants; Carbenoxolone; Convulsants; Electrodes, Implanted; Electroencephalography; | 2012 |
Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Carrier Proteins; Disease Models, Animal; Drug Adminis | 2012 |
Effects of ethylenediamine in rodent models of seizure, motor coordination and anxiety.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Convulsants; Disease Models, Animal; Electro | 2012 |
Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Disease Models, Animal; Electric Stimulation Ther | 2013 |
Neurohypophyseal hormones protect against pentylenetetrazole-induced seizures in zebrafish: role of oxytocin-like and V1a-like receptor.
Topics: Animals; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Dose-Response Relationship, Dru | 2012 |
Involvement of dopaminergic system in stress-induced anticonvulsant effect in juvenile mice.
Topics: Aging; Animals; Brain; Convulsants; Dopamine; Mice; Microdialysis; Norepinephrine; Pentylenetetrazol | 2012 |
Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation.
Topics: Animals; Cell Cycle; Cell Movement; Convulsants; Hippocampus; Male; Mice; Mice, Inbred ICR; Mitosis; | 2012 |
Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antioxidants; beta Carotene; Brain; Calorimetry, Dif | 2012 |
The mu-opioid receptor-selective peptide antagonists, antanal-1 and antanal-2, produce anticonvulsant effects in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Hand Strength; Male; Mice; | 2013 |
Effects of neuropeptide S on seizures and oxidative damage induced by pentylenetetrazole in mice.
Topics: Animals; Behavior, Animal; Lipid Peroxidation; Male; Mice; Neuropeptides; Oxidative Stress; Pentylen | 2012 |
Cannabidivarin is anticonvulsant in mouse and rat.
Topics: Animals; Anticonvulsants; Cannabinoids; Cannabis; Disease Models, Animal; Female; Hippocampus; In Vi | 2012 |
Morphine exposure induces age-dependent alterations in pentylenetetrazole-induced epileptic behaviors in prepubertal rats.
Topics: Age Factors; Animals; Female; Male; Morphine; Narcotics; Pentylenetetrazole; Rats; Rats, Wistar; Sei | 2013 |
The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Animals; Anticonvulsants; Blood Glucose; Blotting, Western; Ce | 2012 |
Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Electroshock; Heterocyclic Compounds, 3-Ring; Is | 2013 |
Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Chi-Square Distribution; Convulsants; Disease Models, An | 2013 |
The effect of dorsal hippocampal administration of nicotinic and muscarinic cholinergic ligands on pentylenetetrazol-induced generalized seizures in rats.
Topics: Animals; Atropine; Hippocampus; Male; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotin | 2012 |
Acute creatine administration improves mitochondrial membrane potential and protects against pentylenetetrazol-induced seizures.
Topics: Animals; Creatine; Humans; Male; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; | 2013 |
Design, synthesis and evaluation of N-(substituted benzothiazol-2-yl)amides as anticonvulsant and neuroprotective.
Topics: Acrylamide; Amides; Animals; Anticonvulsants; Benzothiazoles; Brain; Dose-Response Relationship, Dru | 2012 |
The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Electroence | 2012 |
Seizure control by ketogenic diet-associated medium chain fatty acids.
Topics: Animals; Anticonvulsants; Caprylates; Cell Line; Chemical and Drug Induced Liver Injury; Convulsants | 2013 |
The effects of zinc treatment on the blood-brain barrier permeability and brain element levels during convulsions.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Stem; Cerebellum; Chlorides; Convulsants; Copper | 2013 |
Synthesis and anticonvulsant properties of new N-Mannich bases derived from 3,3-diphenyl- and 3-ethyl-3-methyl-pyrrolidine-2,5-diones. Part III.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Male; Mannich Bases; Mice; | 2013 |
Differential seizure response in two models of cortical heterotopia.
Topics: Agenesis of Corpus Callosum; Animals; Cerebral Cortex; Choristoma; Convulsants; Disease Models, Anim | 2013 |
Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Topics: Animals; Arachidonic Acid; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Diclofenac; Enzyme Inhi | 2012 |
Anticonvulsant action of indazole.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2013 |
Triterpene 3β, 6β, 16β trihidroxilup-20(29)-ene protects against excitability and oxidative damage induced by pentylenetetrazol: the role of Na(+),K(+)-ATPase activity.
Topics: Animals; Enzyme Activation; Injections, Intraventricular; Mice; Neuroprotective Agents; Oxidative St | 2013 |
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks La | 2012 |
Effect of Anacyclus pyrethrum on pentylenetetrazole-induced kindling, spatial memory, oxidative stress and rho-kinase II expression in mice.
Topics: Animals; Asteraceae; Glutathione; Kindling, Neurologic; Male; Maze Learning; Memory; Memory Disorder | 2013 |
Oxytocin inhibits pentylentetrazol-induced seizures in the rat.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Male; Oxyt | 2013 |
Estrogen-dependent effect of soy extract on pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Female; Glycine max; Male; Ovariectomy; Pentylenetetrazole; Phytoestrogens | 2012 |
Effects of different extracts of Eugenia caryophyllata on pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred BALB C; Pentyle | 2012 |
[The antiepileptic role of 3α-androstanediol on the epileptic rats induced by pentylenetetrazole].
Topics: Androstane-3,17-diol; Animals; Anticonvulsants; Electroencephalography; Epilepsy; Male; Pentylenetet | 2012 |
[Effect of acute stress stimulation on the seizure induction in epileptic model rats].
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Lithium Chloride; Pentylenetetrazole; P | 2012 |
Phenytoin-based bivalent ligands: design, synthesis and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Electroshock; Female; Ligan | 2012 |
Anticonvulsant, neuroprotective and behavioral effects of organic and conventional yerba mate (Ilex paraguariensis St. Hil.) on pentylenetetrazol-induced seizures in Wistar rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Catalase; Chromatography, High Pressure Liquid; Conv | 2013 |
Effects of thioperamide on seizure development and memory impairment induced by pentylenetetrazole-kindling epilepsy in rats.
Topics: Animals; Anticonvulsants; Cyclic AMP Response Element-Binding Protein; Histamine H3 Antagonists; Kin | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cycloh | 2013 |
Effects of transcranial focal electrical stimulation via tripolar concentric ring electrodes on pentylenetetrazole-induced seizures in rats.
Topics: Animals; Electric Stimulation Therapy; Electrodes; Electroencephalography; Male; Pentylenetetrazole; | 2013 |
Neuropharmacological in vivo effects and phytochemical profile of the extract from the aerial parts of Heteropterys brachiata (L.) DC. (Malpighiaceae).
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Anxiety; Chlorogenic Acid; Fem | 2013 |
A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats.
Topics: Animals; Cell Proliferation; Cognition Disorders; Disease Progression; Hippocampus; Male; Maze Learn | 2013 |
Behavioural and histopathological assessment of the effects of periodic fasting on pentylenetetrazol-induced seizures in rats.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy; Fasting; Hippocampus; Male; Neurons; Pentylene | 2013 |
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hi | 2013 |
Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.
Topics: Animals; Anticonvulsants; Locomotion; Pentylenetetrazole; Seizures; Zebrafish | 2013 |
Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats.
Topics: Animals; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Convulsants; Disease Models, Animal; El | 2013 |
Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats.
Topics: Animals; Biological Clocks; Brain; Convulsants; Electrodes, Implanted; Electroencephalography; Equip | 2012 |
Sensor integration of multiple tripolar concentric ring electrodes improves pentylenetetrazole-induced seizure onset detection in rats.
Topics: Algorithms; Animals; Diagnosis, Computer-Assisted; Electrodes; Electroencephalography; Equipment Des | 2012 |
Anticonvulsant evaluation of aminoalkanol derivatives of 2- and 4-methylxanthone.
Topics: Animals; Anticonvulsants; Calcium Channels; Electroshock; Injections, Intraperitoneal; Mice; Neurons | 2013 |
Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Dose-Response Relationship, Drug; GABA-B Receptor Agon | 2013 |
Anticonvulsant and sedative-hypnotic activities of N-substituted isatin semicarbazones.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Convulsants; Hypnotics and Sedati | 2002 |
Anticonvulsant and sedative effects of Salvadora persica L. stem extracts.
Topics: Animals; Anticonvulsants; Celastraceae; Drug Synergism; Female; Hypnotics and Sedatives; Lethal Dose | 2002 |
Behavior and physiology of mice lacking the GABAA-receptor delta subunit.
Topics: Animals; Behavior, Animal; Cell Membrane; Disease Susceptibility; Female; Kinetics; Male; Mice; Mice | 2002 |
Progesterone reduces pentylenetetrazol-induced ictal activity of wild-type mice but not those deficient in type I 5alpha-reductase.
Topics: Animals; Convulsants; Female; Mice; Mice, Knockout; Oxidoreductases; Pentylenetetrazole; Progesteron | 2002 |
Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.
Topics: Aminophylline; Amygdala; Anesthetics; Animals; Anticonvulsants; Avoidance Learning; Convulsants; Dru | 2002 |
Ketogenic diet: does acetone stop seizures?
Topics: Acetone; Animals; Anticonvulsants; Cerebrospinal Fluid; Convulsants; Diet; Epilepsy; Fasting; Humans | 2002 |
Long-lasting potentiation effects induced in rats by kindling with an inverse agonist of the benzodiazepine receptor.
Topics: Animals; Behavior, Animal; Carbolines; Convulsants; Dentate Gyrus; Electric Stimulation; Electrodes, | 2002 |
Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Brain Chemistry; Elect | 2002 |
Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.
Topics: 4-Aminopyridine; Animals; Bicuculline; Binding, Competitive; Brain; Convulsants; Dose-Response Relat | 2002 |
Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems.
Topics: Animals; Avoidance Learning; Biogenic Monoamines; Brain; Conditioning, Psychological; Emotions; Kind | 2002 |
Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice.
Topics: Acetone; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; E | 2002 |
Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine: part 2. Synthesis and pharmacological activity of 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-a][1,3,5]triazines.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Behavior, Animal; Binding, Competitive; Body Tempe | 2002 |
Dose-, time-, age-, and sex-response profiles for the anticonvulsant effects of deoxycorticosterone in 15-day-old rats.
Topics: Age Factors; Animals; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Response R | 2002 |
Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cognition Disorders; Cyclic AMP Response Element | 2002 |
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonv | 2002 |
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Depressants; Chlordiazepoxide | 2002 |
Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Lamotri | 2002 |
Potentiation of the ionotropic GABA receptor response by whiskey fragrance.
Topics: Alcoholic Beverages; Animals; Brain Chemistry; Cattle; Drug Synergism; Female; GABA Antagonists; Gen | 2002 |
Anxiolytic and antiemetic activity of Zingiber officinale.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Avoidance Learning; Male; Maze Learning; | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relati | 2002 |
Neuropharmacological screening of Diospyros mespiliformis in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diospyros; Dose-Response Relationship, Drug; Hypnotics a | 2002 |
Pentylenetetrazol-induced seizures and kindling: changes in free fatty acids, superoxide dismutase, and glutathione peroxidase activity.
Topics: Animals; Brain; Cerebellum; Epilepsy, Tonic-Clonic; Fatty Acids, Nonesterified; Female; Glutathione | 2003 |
Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines.
Topics: Amphetamine; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epinephr | 2002 |
Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats?
Topics: Animals; Animals, Newborn; Anticonvulsants; Convulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clon | 2002 |
Pentylenetetrazol-kindling of seizures selectively decreases [3H]-citalopram binding in the CA-3 area of rat hippocampus.
Topics: Animals; Autoradiography; Carrier Proteins; Citalopram; Convulsants; Hippocampus; Immunohistochemist | 2002 |
N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities.
Topics: Animals; Anticonvulsants; Binding Sites; Electroshock; gamma-Aminobutyric Acid; Glycine; Male; Model | 2003 |
The effect of the 'classic' ketogenic diet on animal seizure models.
Topics: Animals; Disease Models, Animal; Electroshock; Ketone Bodies; Male; Pentylenetetrazole; Rats; Rats, | 2003 |
Assessment of the seizure susceptibility of Wistar Audiogenic rat to electroshock, pentyleneterazole and pilocarpine.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Electroshock; | 2003 |
CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.
Topics: Animals; Brain Ischemia; Hippocampus; Male; Motor Activity; Neuroprotective Agents; Pentylenetetrazo | 2003 |
Seizure-mediated neuronal activation induces DREAM gene expression in the mouse brain.
Topics: Animals; Calcium-Binding Proteins; Convulsants; Cycloheximide; Dizocilpine Maleate; Gene Expression | 2002 |
Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Design; GABA-A Receptor Agonists; Indicators a | 2003 |
Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats.
Topics: Animals; Centella; Cognition; Kindling, Neurologic; Male; Oxidative Stress; Pentylenetetrazole; Plan | 2003 |
NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility.
Topics: Animals; Animals, Newborn; Brain; Cognition Disorders; Convulsants; Electroencephalography; Excitato | 2003 |
Metabolism of brain amino acids following pentylenetetrazole treatment.
Topics: Alanine; Amino Acids; Animals; Brain Chemistry; Convulsants; Gas Chromatography-Mass Spectrometry; G | 2003 |
Neuraminidase activity in different regions of the seizing epileptic and non-epileptic brain.
Topics: Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Convulsants; Epilepsy; GABA Antagonists; Hi | 2003 |
The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception.
Topics: Angiotensin II; Animals; Avoidance Learning; Disease Models, Animal; Drug Combinations; Imidazoles; | 2003 |
Anterior thalamic mediation of experimental seizures: selective EEG spectral coherence.
Topics: Animals; Cerebral Cortex; Electrodes, Implanted; Electroencephalography; Fourier Analysis; Hippocamp | 2003 |
Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor.
Topics: Animals; Disease Models, Animal; Electroencephalography; GABA Antagonists; Mice; Mice, Inbred C57BL; | 2003 |
Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice.
Topics: Analysis of Variance; Animals; Brain; Brain Chemistry; Convulsants; Histamine; Histidine Decarboxyla | 2003 |
Anti-nociceptive and anti-inflammatory effects of methanolic extract of Asparagus pubescens root in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior | 2003 |
Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Synergism; | 2003 |
Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures.
Topics: Animals; Dose-Response Relationship, Immunologic; Dysentery, Bacillary; Mice; Mice, Inbred ICR; Pent | 2003 |
Adenosine receptors do not mediate the melatonin protection against pentylenetetrazole induced seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Male; Melatonin; Pentylenetetrazole; Purinergic P1 Receptor Ant | 2001 |
The influence of anticonvulsant and antioxidant drugs on nitric oxide level and lipid peroxidation in the rat brain during penthylenetetrazole-induced epileptiform model seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Lipid Peroxidation; Male; Nitric Oxide; Pentylenetetr | 2003 |
Evaluation of toluene dependence and cross-sensitization to diazepam.
Topics: Animals; Convulsants; Diazepam; Excitatory Amino Acid Agonists; Inhalation Exposure; Male; Mice; Mot | 2003 |
Calorie restriction of a high-carbohydrate diet elevates the threshold of PTZ-induced seizures to values equal to those seen with a ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Convulsants; Dietary Carbohydrates; Dietary Fats; Energ | 2003 |
Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug In | 2003 |
Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, | 2003 |
Pentylenetetrazole decreases metabolic glutamate turnover in rat brain.
Topics: Animals; Brain; Brain Chemistry; Carbon Isotopes; Cerebellum; Cerebral Cortex; Chromatography, High | 2003 |
Prediction of PTZ-induced seizures using wavelet-based residual entropy of cortical and subcortical field potentials.
Topics: Algorithms; Animals; Cerebral Cortex; Electroencephalography; Electromagnetic Fields; Male; Pentylen | 2003 |
Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats.
Topics: Animals; Blood-Brain Barrier; Brain Chemistry; Coloring Agents; Copper; Disease Models, Animal; Evan | 2003 |
Influence of hypoosmolality on the blood-brain barrier permeability during epileptic seizures.
Topics: Animals; Blood-Brain Barrier; Convulsants; Osmosis; Pentylenetetrazole; Permeability; Rats; Rats, Wi | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Male; Melatonin; Nitric Oxide; Pentylenet | 2003 |
Dentate granule cell neurogenesis after seizures induced by pentylenetrazol in rats.
Topics: Animals; Antigens, Nuclear; Benzopyrans; Bromodeoxyuridine; Calbindins; Cell Count; Cell Division; C | 2003 |
Brain levels of N-acylethanolamine phospholipids in mice during pentylenetetrazol-induced seizure.
Topics: Age Factors; Animals; Arylamine N-Acetyltransferase; Carbon Radioisotopes; Cerebral Cortex; Convulsa | 2003 |
Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Histamine; Histamine Release; Histidine; | 2003 |
Interaction between local anesthetics and centrally acting antihypertensive drugs.
Topics: Anesthetics, Local; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Drug Evaluat | 2002 |
Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice.
Topics: Animals; Convulsants; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Oleic Acids; Pentylene | 2003 |
Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L.
Topics: Animals; Anticonvulsants; Artemisia; Central Nervous System Agents; Convulsants; Ethanol; Gas Chroma | 2003 |
[Role of NMDA and AMPA glutamate receptors in the mechanism of korazol-induced convulsions in mice].
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mole | 2003 |
On the state of convulsion-readiness (Krampfbereitschaft) of the epileptics.
Topics: Epilepsy; Humans; Pentylenetetrazole; Seizures | 1951 |
Effect of convulsion inducing agents on the acetylcholine content and on the electrical activity of the brain.
Topics: Acetylcholine; Brain; Cerebral Cortex; Nervous System Physiological Phenomena; Neurochemistry; Penty | 1953 |
Cortical and subcortical electrical activity in experimental seizures induced by metrazol.
Topics: Cerebral Cortex; Pentylenetetrazole; Seizures | 1953 |
Comparison of maximal seizures evoked by pentylenetetrazol (metrazol) and electroshock in mice, and their modification by anticonvulsants.
Topics: Animals; Anticonvulsants; Electricity; Electroshock; Mice; Pentylenetetrazole; Seizures | 1953 |
A note on the effect of cortisone and desoxycorticosterone on metrazol convulsions in mice.
Topics: Animals; Cortisone; Desoxycorticosterone; Mice; Pentylenetetrazole; Seizures | 1953 |
Convulsive threshold values to parenterally injected pentamethylenetetrazole in epileptic monkeys.
Topics: Animals; Epilepsy; Haplorhini; Humans; Pentylenetetrazole; Seizures | 1953 |
[Clinical and experimental studies on leukocytosis in cardiazol induced convulsions; studies on a central nervous system induced leukocytosis].
Topics: Central Nervous System; Humans; Leukocyte Disorders; Leukocytosis; Pentylenetetrazole; Seizures | 1953 |
[Electrical and clinical comparison of spontaneous temporal seizure and of the effect of cardiazol in the same patient; film presentation].
Topics: Epilepsy; Humans; Pentylenetetrazole; Seizures | 1953 |
The effect of cardiazol convulsions on the distribution and activity of some phosphatases in the area postrema of the rat.
Topics: Animals; Area Postrema; Cerebral Ventricles; Pentylenetetrazole; Phosphoric Monoester Hydrolases; Ra | 1954 |
Convulsive seizures during oral pentylenetetrazol therapy.
Topics: Aged; Disease; Humans; Pentylenetetrazole; Seizures | 1954 |
Effect of metrazol and nembutal on motor activity in the spinal cat.
Topics: Animals; Barbiturates; Cats; Felis; Motor Activity; Pentobarbital; Pentylenetetrazole; Seizures; Spi | 1955 |
The relation between the oxygen consumption of the cerebral cortex of the rabbit and its electrical activities during metrazol convulsions.
Topics: Animals; Arsenicals; Cerebral Cortex; Electroencephalography; Oxygen Consumption; Pentylenetetrazole | 1954 |
[Hippocratic, experimental and clinical thinking in convulsion therapy; metalegomena on cardiazol convulsion by L. V. Meduna].
Topics: Convulsive Therapy; Humans; Pentylenetetrazole; Seizures; Thinking | 1954 |
[Metrazólica photo-activation, epilepsy and thalamocortical connections].
Topics: Cerebral Cortex; Epilepsy; Light; Nervous System Physiological Phenomena; Pentylenetetrazole; Seizur | 1955 |
Pentylenetetrazole and thiosemicarbazide: a study of convulsant activity in the isolated cerebral cortex preparation.
Topics: Cerebral Cortex; Convulsants; Hydrazines; Pentylenetetrazole; Seizures; Semicarbazides | 1955 |
[Susceptibility to convulsions in phylogenesis; experimental convulsions in vertebrates produced with cardiazole].
Topics: Animals; Disease Susceptibility; Pentylenetetrazole; Phylogeny; Seizures; Vertebrates | 1955 |
[Potentiation of experimental camphor, cardiazol and strychnine convulsions following administration of reserpine or whole Rauwolfia serpentina alkaloids].
Topics: Antihypertensive Agents; Camphor; Pentylenetetrazole; Rauwolfia; Reserpine; Secologanin Tryptamine A | 1955 |
Anticonvulsant effects of certain CNS depressants in convulsions induced by strychnine, metrazol or caffeine.
Topics: Anticonvulsants; Caffeine; Central Nervous System Depressants; Pentylenetetrazole; Seizures; Strychn | 1956 |
Paroxysmal susceptibility in the light of phylogenesis; experimental convulsions in vertebrates, elicited by cardiazol.
Topics: Animals; Disease Susceptibility; Pentylenetetrazole; Phylogeny; Seizures; Vertebrates | 1955 |
[Technic of management of sleeping drug poisoning with cardiazol convulsions].
Topics: Disease Management; Humans; Hypnotics and Sedatives; Pentylenetetrazole; Seizures | 1956 |
[Technic of management of sleeping drug poisoning with cardiazol convulsions].
Topics: Disease Management; Humans; Hypnotics and Sedatives; Pentylenetetrazole; Seizures | 1956 |
[Technic of management of sleeping drug poisoning with cardiazol convulsions].
Topics: Disease Management; Humans; Hypnotics and Sedatives; Pentylenetetrazole; Seizures | 1956 |
[Technic of management of sleeping drug poisoning with cardiazol convulsions].
Topics: Disease Management; Humans; Hypnotics and Sedatives; Pentylenetetrazole; Seizures | 1956 |
Succinylcholine chloride in electroencephalography.
Topics: Electroencephalography; Humans; Pentylenetetrazole; Seizures; Succinylcholine | 1957 |
Succinylcholine chloride in electroencephalography.
Topics: Electroencephalography; Humans; Pentylenetetrazole; Seizures; Succinylcholine | 1957 |
Succinylcholine chloride in electroencephalography.
Topics: Electroencephalography; Humans; Pentylenetetrazole; Seizures; Succinylcholine | 1957 |
Succinylcholine chloride in electroencephalography.
Topics: Electroencephalography; Humans; Pentylenetetrazole; Seizures; Succinylcholine | 1957 |
[Relation between the hypertensive and epiletogen effects of penta-methylene-tetrazole].
Topics: Blood Pressure; Blood Pressure Determination; Humans; Hypertension; Pentylenetetrazole; Rubiaceae; S | 1957 |
[Use of the convulsion test with oral cardiazol in diagnosis of epilepsy].
Topics: Epilepsy; Humans; Pentylenetetrazole; Seizures | 1956 |
[Study of the variations of convulsive seizure induced by cardiazol in chloralose-treated animals].
Topics: Animals; Chloralose; Hypnotics and Sedatives; Pentylenetetrazole; Seizures | 1956 |
[Spasmophilia and age; studies on cardiazol convulsive threshold in rabbits].
Topics: Aging; Animals; Humans; Lagomorpha; Pentylenetetrazole; Rabbits; Seizures; Tetany | 1956 |
Relationships of the predisposition to convulsions with the action potentials of the autonomic nerves and the brain. II. Changes in action potential of the autonomic nerves and the brain under conditions for increasing the predisposition to convulsions.
Topics: Action Potentials; Autonomic Nervous System; Autonomic Pathways; Brain; Disease Susceptibility; Huma | 1957 |
[Electro-clinical study of induced seizures as method of detection and diagnosis of epilepsy].
Topics: Biomedical Research; Epilepsy; Humans; Pentylenetetrazole; Seizures | 1956 |
[Therapeutic convulsions as a life-saving therapy].
Topics: Convulsive Therapy; Life; Pentylenetetrazole; Seizures | 1957 |
[Audiogenic, pentamethylenetetrazole and strychnine convulsions in adrenalectomized rats].
Topics: Adrenalectomy; Animals; Pentylenetetrazole; Rats; Seizures; Sound; Strychnine | 1958 |
[Danger of precipitation of seizure by cardiazol activation during electroencephalographic studies].
Topics: Electroencephalography; Epilepsy; Humans; Immune System Phenomena; Pentylenetetrazole; Seizures | 1957 |
Metabolism of the perfused cat brain during metrazol convulsions and electroshock.
Topics: Animals; Brain; Carbon Dioxide; Cats; Electricity; Electroshock; Hemorrhage; Pentylenetetrazole; Sei | 1958 |
[Influence of changes of serotonin content of the central nervous system on the seizure threshold of cardiazol].
Topics: Central Nervous System; Pentylenetetrazole; Seizures; Serotonin | 1958 |
[Effects of serotonin metabolism on the metrazol convulsion threshold in mice].
Topics: Animals; Hemorrhage; Mice; Pentylenetetrazole; Seizures; Serotonin | 1958 |
[Conditioned reflex reactions in cardiazol convulsions].
Topics: Conditioning, Classical; Nervous System Physiological Phenomena; Pentylenetetrazole; Reflex; Seizure | 1958 |
Pentylenetetrazol seizure threshold in meprobamate- and phenaglycodol-treated mice.
Topics: Animals; Butylene Glycols; Meprobamate; Mice; Pentylenetetrazole; Seizures; Tranquilizing Agents | 1959 |
[The effects of various steroids and the removal of the thyroid and parathyroid glands on convulsions induced by pentamethylenetetrazole].
Topics: Parathyroid Glands; Pentylenetetrazole; Seizures; Steroids; Thyroid Gland | 1959 |
Convulsant properties of oral pentylenetetrazol mixtures.
Topics: Convulsants; Pentylenetetrazole; Seizures | 1959 |
Modification of metrazol-induced convulsions by ablations of the brain; a study in the salamander.
Topics: Animals; Brain; Humans; Pentylenetetrazole; Seizures; Urodela | 1959 |
[Modification of blood proteins after pentetrazole crisis in curarized rabbits].
Topics: Animals; Blood Proteins; Pentylenetetrazole; Rabbits; Seizures | 1959 |
The effects of reserpine and other agents upon leptazol convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Dihydroxyphenylalanine; Iproniazid; Mice; Pentylenetetrazole; R | 1959 |
Nantenine alkaloid presents anticonvulsant effect on two classical animal models.
Topics: Alkaloids; Animals; Anticonvulsants; Aporphines; Disease Models, Animal; Dose-Response Relationship, | 2003 |
Levels of serotonin during convulsion and the effect of reserpine.
Topics: Pentylenetetrazole; Reserpine; Seizures; Serotonin | 1961 |
[Comparison of the respiratory analeptic and convulsive properties of pentylenetetrazole and bemegride under the influence of morphine].
Topics: Bemegride; Central Nervous System Stimulants; Morphine; Pentylenetetrazole; Respiration; Seizures | 1960 |
Retrograde amnesia produced by anesthetic and convulsant agents.
Topics: Amnesia; Amnesia, Retrograde; Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthetics; Convulsa | 1961 |
Effects of environmental temperature on pentylenetetrazol convulsions in corpus callotomized white rats.
Topics: Animals; Brain; Hemispherectomy; Pentylenetetrazole; Psychosurgery; Rats; Seizures; Split-Brain Proc | 1961 |
The effect of sodium fluoride on responses to various central nervous system agents in rats.
Topics: Animals; Central Nervous System Agents; Pentylenetetrazole; Rats; Seizures; Sodium Fluoride; Strychn | 1961 |
Changes in the pentose-nucleic acid content of sub-cellular fractions of the brain of the rat during 'Metrazol' convulsions.
Topics: Animals; Brain; Carbohydrate Metabolism; Nucleic Acids; Pentoses; Pentylenetetrazole; Rats; Seizures | 1961 |
The convulsive patterns provoked by indoklon, metrazol and electroshock: some depth electrographic observations in human patients.
Topics: Electroencephalography; Electroshock; Flurothyl; Humans; Pentylenetetrazole; Seizures | 1960 |
Cardiazol convulsion therapy in some psychotic cases.
Topics: Convulsive Therapy; Humans; Mental Disorders; Pentylenetetrazole; Psychotic Disorders; Seizures | 1959 |
Evaluation of variables for the 'timed intravenous infusion' procedure for pentyleneterazol seizures in mice.
Topics: Animals; Infusions, Intravenous; Mice; Pentylenetetrazole; Seizures | 1960 |
The facilitative action of reserpine on metrazol convulsions when modified by iproniazid.
Topics: Iproniazid; Pentylenetetrazole; Reserpine; Seizures | 1960 |
[Comparative studies on the convulsive action of bemegrid, pentetrazol and picrotoxin].
Topics: Central Nervous System Stimulants; Pentylenetetrazole; Picrotoxin; Seizures | 1962 |
[Study of the role of different segments of the central nervous system in the mechanism of the convulsive action of corazole].
Topics: Central Nervous System; Pentylenetetrazole; Seizures | 1963 |
[Cardiazol convulsions in the normal and hypocalcemic animal (symptomatologic picture and EEG)].
Topics: Animals; Electroencephalography; Hypocalcemia; Oxalates; Pentylenetetrazole; Seizures | 1962 |
[Experimental research on the relation between female sex steroids and epilepsy. I. Action of progesterone and estrone sulfate on the metrazole test].
Topics: Epilepsy; Estrone; Female; Pentylenetetrazole; Progesterone; Seizures; Steroids | 1962 |
Some neurophysiological and neuropharmacological characteristics of audiogenic-seizure-susceptible mice.
Topics: Animals; Epilepsy, Reflex; Mice; Pentylenetetrazole; Seizures | 1963 |
Effect of aldosterone and cortisol on leptazol-induced seizures in rats.
Topics: Aldosterone; Animals; Hydrocortisone; Male; Pentylenetetrazole; Rats; Seizures | 1962 |
[Bioelectrical activity of different levels of the nervous system in rabbits during convulsions induced with metrazole].
Topics: Animals; Autonomic Nervous System; Ganglia; Ganglia, Autonomic; Pentylenetetrazole; Rabbits; Seizure | 1963 |
Effect of chlorpromazine and prochlorperazine on metrazol induced convulsions in frogs.
Topics: Animals; Anura; Chlorpromazine; Pentylenetetrazole; Prochlorperazine; Ranidae; Seizures | 1963 |
[Urinary elimination of 5-hydroxyindolacetic acid in rabbits after cardiazol convulsions].
Topics: Animals; Body Fluids; Hydroxyindoleacetic Acid; Indoleacetic Acids; Pentylenetetrazole; Rabbits; Sei | 1961 |
THE EFFECT OF EXPERIMENTALLY-INDUCED STRESS ON PENTYLENETETRAZOL SEIZURE THRESHOLD IN MICE.
Topics: Animals; Conditioning, Psychological; Mice; Pentylenetetrazole; Research; Seizures; Stress, Physiolo | 1963 |
PHARMACOLOGICAL PROPERTIES OF PENTAERYTHRITOL DERIVATIVES. II.MONOBENZALPENTAERYTHRITOL, A COMPOUND STIMULATING THE CENTRAL NERVOUS SYSTEM.
Topics: Cats; Central Nervous System Stimulants; Mephenesin; Mice; Pentylenetetrazole; Pharmacology; Phenoba | 1962 |
CONTRASTING BEHAVIORAL, PHARMACOLOGICAL, NEUROPHYSIOLOGICAL, AND BIOCHEMICAL PROFILES OF C57 B1/6 AND SC-I STRAINS OF MICE.
Topics: Adrenal Glands; Aggression; Animals; Avoidance Learning; Behavior, Animal; Chlorpromazine; Mice; Neu | 1963 |
ELECTROGRAPHIC STUDY ON THERAPEUTIC CARDIAZOLIC CONVULSIONS UNDER MUSCLE RELAXATION.
Topics: Convulsive Therapy; Electrocardiography; Electroencephalography; Electromyography; Humans; Muscle Re | 1963 |
PHARMACOLOGICAL STUDY OF PHENYLCARBAMIDE DERIVATIVES WITH A VIEW TO THE RELATION BETWEEN THEIR CHEMICAL STRUCTURE AND ANTICONVULSION EFFECT.
Topics: Anticonvulsants; Chemical Phenomena; Chemistry; Mice; Pentylenetetrazole; Pharmacology; Phenylurea C | 1963 |
THE ROLE OF SODIUM CHLORIDE IN THE EXCITABILITY OF THE CENTRAL NERVOUS SYSTEM OF THE RAT.
Topics: Central Nervous System; Conditioning, Classical; Diet, Sodium-Restricted; Electricity; Electroenceph | 1963 |
[INFLUENCE OF ISOCARBOXAZID (MARPLAN) AND 2 NEW MAO INHIBITORS ON CLONIC CONVULSIONS AND MORTALITY INDUCED BY METRAZOLE].
Topics: Antihypertensive Agents; Isocarboxazid; Mice; Monoamine Oxidase Inhibitors; Pentylenetetrazole; Phar | 1963 |
A PROPOSED COMMON MECHANISM OF ACTION FOR GENERAL AND LOCAL ANAESTHETICS IN THE CENTRAL NERVOUS SYSTEM.
Topics: Action Potentials; Anesthesia, Local; Anesthetics, Local; Animals; Cats; Central Nervous System; Cer | 1963 |
FREE AMINO ACIDS AND RELATED COMPOUNDS IN DOG BRAIN: POST-MORTEM AND ANOXIC CHANGES, EFFECTS OF AMMONIUM CHLORIDE INFUSION, AND LEVELS DURING SEIZURES INDUCED BY PICROTOXIN AND BY PENTYLENETETRAZOL.
Topics: Amino Acids; Ammonium Chloride; Autopsy; Brain; Dogs; Hypoxia; Pathology; Pentylenetetrazole; Pharma | 1963 |
[PARATHYROID SECRETION AND CENTRAL NERVOUS EXCITABILITY. DEMONSTRATION OF AN ELECTROPHYSIOLOGICAL TEST PERMITTING EVALUATION OF THE "CALCIC STATE" OF THE RABBIT].
Topics: Blood Chemical Analysis; Brain; Calcium; Calcium Compounds; Calcium, Dietary; Oxides; Parathyroid Gl | 1963 |
[THE ROLE OF THE MESENCEPHALIC RETICULAR FORMATION IN AUDIOGENIC AND TETRACOR-INDUCED SEIZURES].
Topics: Mesencephalon; Midbrain Reticular Formation; Pentylenetetrazole; Rats; Research; Reticular Formation | 1963 |
PARTIAL AGONISTS IN THE CENTRAL NERVOUS SYSTEM.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Hypnotics and Sedatives; Mic | 1963 |
THE ANTICONVULSANT ACTIVITY OF ETHYL ALPHA-PHENYLBUTYROYL ALLOPHANATE (P-5257).
Topics: Anticonvulsants; Barbiturates; Carbamates; Central Nervous System; Mice; Pentylenetetrazole; Pharmac | 1963 |
STIMULANT EFFECTS OF TETRAHYDROCYCLOHEPTAQUINOLINE DERIVATIVES.
Topics: Acridines; Amphetamine; Amphetamines; Barbiturates; Behavior, Animal; Blood Pressure; Blood Pressure | 1963 |
[ON PHYSIOLOGICAL ANALYSIS OF "PREDISPOSITION TO CONVULSIONS"].
Topics: Brain; Camphor; Cerebral Cortex; Disease Susceptibility; Electrophysiological Phenomena; Electrophys | 1963 |
EFFECTS OF SEIZURES ON SINGLE PYRAMIDAL TRACT NEURONS.
Topics: Brain; Cats; Cerebral Cortex; Electrophysiology; Neurons; Pentylenetetrazole; Pyramidal Tracts; Rese | 1964 |
THE INFLUENCE OF EXPERIMENTAL CEREBRAL HYPOXIA ON CONVULSIVE RESPONSES TO CARDIAZOL.
Topics: Carotid Artery Thrombosis; Cats; Cerebrovascular Disorders; Electroencephalography; Epilepsy; Hypoxi | 1963 |
[COMPARATIVE PATHOPHYSIOLOGY OF THE EPILEPTIC SEIZURE].
Topics: Convulsive Therapy; Electricity; Electroconvulsive Therapy; Electroencephalography; Epilepsy; Humans | 1964 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System | 1963 |
ANTIMALARIALS AND OTHER ANTICONVULSANT DRUGS: PREDICTIVE VALIDITY OF LABORATORY TESTS.
Topics: Animals; Anticonvulsants; Antimalarials; Chloroquine; Electric Stimulation; Hydroxychloroquine; Mice | 1964 |
[HYPERGLYCORRHACHIA, GLYCEMIA AND CONVULSIONS].
Topics: Blood Glucose; Cerebrospinal Fluid; Child; Eosinophils; Glucose; Hyperglycemia; Leukocyte Count; Pen | 1964 |
[COMPOSITION OF ACETYLCHOLINE IN THE MOUSE BRAIN AND ITS CHANGES UNDER VARIOUS PHYSIOLOGICAL CONDITIONS].
Topics: Acetylcholine; Anesthesia; Animals; Biochemical Phenomena; Biochemistry; Brain; Electric Stimulation | 1964 |
[ON SEVERAL COUMARIN DERIVATIVES].
Topics: Analgesia; Burns; Chemistry, Pharmaceutical; Coumarins; Mice; Pentylenetetrazole; Pharmacology; Phar | 1964 |
THE CONVULSIVE EFFECT OF BEMEGRID.
Topics: Animals; Bemegride; Lagomorpha; Pentylenetetrazole; Rabbits; Research; Seizures; Toxicology | 1964 |
[SULFONAMIDES WITH CENTRAL NERVOUS SYSTEM ACTION. II. 2-ACYLAMINOBENZENE-SULFONAMIDES].
Topics: Anticonvulsants; Central Nervous System; Chemistry, Pharmaceutical; Pentylenetetrazole; Pharmacology | 1964 |
A NEUROCHEMICAL STUDY OF THIOSEMICARBAZIDE SEIZURES AND THEIR INHIBITION BY AMINO-OXYACETIC ACID.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Azides; Brain; Dogs | 1964 |
[CHANGE IN THE SORPTIVE PROPERTIES OF CENTRAL NERVOUS SYSTEM AND ADRENAL GLAND TISSUES DURING THE CONVULSIVE ACTION OF STRYCHNINE, CORAZOLE AND OXYGEN].
Topics: Adrenal Glands; Animals; Brain Stem; Central Nervous System; Cerebral Cortex; Mice; Nerve Tissue; Ox | 1964 |
(ON THE ANTICONVULSIVE EFFECT OF SOME BULGARIAN PLANTS.)
Topics: Anticonvulsants; Electricity; Language; Mice; Pentylenetetrazole; Pharmacology; Plants, Medicinal; R | 1964 |
THE ANTICONVULSANT PROPERTIES OF SOME SUBSTITUTED BENZAMIDES.
Topics: 4-Aminobenzoic Acid; Amides; Animals; Anticonvulsants; Antipsychotic Agents; Benzamides; Mice; Penty | 1963 |
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF PHENYL-SUBSTITUTED BIURETS.
Topics: Atropine; Biuret; Chemistry, Pharmaceutical; Gastric Juice; Meprobamate; Mice; Nicotine; Pentylenete | 1963 |
[THE ANTICONVULSANT ACTIVITY OF ARISAEMA JAPONICUM BL].
Topics: Anticonvulsants; Arisaema; Caffeine; Electric Injuries; Epilepsy; Mice; Pentylenetetrazole; Pharmaco | 1964 |
CHANGES IN THE RIBONUCLEIC ACID CONTENT OF THE BRAIN DURING EXPERIMENTALLY INDUCED CONVULSIONS.
Topics: Brain; Cell Nucleus; Cytoplasm; Liver; Metabolism; Muscles; Organ Specificity; Pentylenetetrazole; P | 1964 |
COMPARATIVE NEUROTOXICITY AND ANTIPENTYLENETETRAZOL ACTIVITY OF SOME PIPERIDINEDIONES.
Topics: Bemegride; Glutethimide; Hypnotics and Sedatives; Mice; Pentylenetetrazole; Pharmacology; Phenobarbi | 1964 |
ELECTROCONVULSIVE RESPONSES OF RATS TO CONVULSANT AND ANTICONVULSANT DRUGS DURING ACCLIMATIZATION AT HIGH ALTITUDE (12,470 FEET, 3,800 M).
Topics: Acclimatization; Acetazolamide; Altitude; Anticonvulsants; Convulsants; Electric Stimulation; Neurop | 1964 |
PREPARATION AND ANTICONVULSANT ACTIVITY OF N-SUBSTITUTED BENZENEDISULFONAMIDES.
Topics: Animals; Anticonvulsants; Brain; Carbonic Anhydrase Inhibitors; Chemistry, Pharmaceutical; Mice; Pen | 1963 |
ANTICONVULSANTS. I. DIBENZO(A,D)CYCLOHEPTADIENE-5-CARBOXAMIDE AND RELATED COMPOUNDS.
Topics: Amides; Anticonvulsants; Ataxia; Chemistry, Pharmaceutical; Mice; Pentylenetetrazole; Pharmacology; | 1964 |
CLINICAL APPLICATIONS OF STUDIES ON STEREOTACTICALLY IMPLANTED ELECTRODES IN TEMPORAL-LOBE EPILEPSY.
Topics: Adolescent; Brain; Electrodes, Implanted; Electroencephalography; Electrophysiology; Epilepsy, Tempo | 1963 |
THE ANTICONVULSANT ACTIVITIES OF SOME SUBSTITUTED ACETONAPHTHONES.
Topics: Anticonvulsants; Cats; Chemistry, Pharmaceutical; Mice; Naphthalenes; Pentylenetetrazole; Pharmacolo | 1964 |
INFLUENCE OF METHYLDOPA ON CENTRAL EFFECTS OF RESERPINE.
Topics: Anesthesia; Animals; Birds; Brain; Brain Chemistry; Chlorpromazine; Hexobarbital; Hypnotics and Seda | 1964 |
[THE CENTRAL STIMULATING ACTION OF DIETHYLPROPION IN COMPARISON WITH PHENMETRAZINE AND RACEMIC BENZEDRINE].
Topics: Amphetamine; Amphetamines; Behavior, Animal; Blood Pressure; Body Temperature Regulation; Central Ne | 1964 |
EFFECT OF EPINEPHRINE AND NOREPINEPHRINE ON EXCITABILITY OF CENTRAL NERVOUS SYSTEM OF MICE.
Topics: Central Nervous System; Epinephrine; Mice; Norepinephrine; Pentylenetetrazole; Pharmacology; Researc | 1964 |
[ANTICONVULSIVE EFFECTS OF OXINDOL AND DIOXINDOL].
Topics: Anesthesia; Anesthesiology; Anticonvulsants; Azoles; Electroshock; Hexobarbital; Imides; Indoles; Mi | 1964 |
THE HISTOMORPHOLOGY OF EXPERIMENTAL EXCITATION.
Topics: Acridines; Coloring Agents; Depression; Depressive Disorder; Hippocampus; Histology; Lysergic Acid D | 1964 |
THE ABSENCE OF ANTICONVULSANT PROPERTIES OF QUINACRINE AND CHLOROQUINE IN MICE.
Topics: Anticonvulsants; Chloroquine; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Quinacrine; Res | 1964 |
[ON SOME NEW DERIVATIVES OF ALPHA-(P-CHLOROPHENOXY)-ISOBUTYRIC ACID].
Topics: 4-Aminobenzoic Acid; Amides; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Barbiturates; Benzo | 1964 |
ANTICONVULSIVE ACTION OF SUBSTANCES DESIGNED AS INHIBITORS OF GAMMA-AMINOBUTYRIC ACID-ALPHA-KETOGLUTARIC ACID TRANSAMINASE.
Topics: Aminobutyrates; Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Electricity; Electroshock; Enz | 1964 |
A NEUROPHARMACOLOGICAL STUDY OF GAMMA-AMINOBUTYRIC ACID (GABA).
Topics: Aminobutyrates; Anesthesia; Anesthesia, Intravenous; Behavior, Animal; Brain Chemistry; Cats; Chlorp | 1964 |
MODIFICATION OF METRAZOL INDUCED CONVULSIONS IN RATS BY ADRENAL CORTICAL STEROIDS.
Topics: Adrenal Cortex Hormones; Cortisone; Desoxycorticosterone; Dexamethasone; Hydrocortisone; Pentylenete | 1964 |
CARDIAC EFFECTS OF DIMEFLINE COMPARED WITH THOSE OF OTHER CENTRAL NERVOUS SYSTEM STIMULANTS.
Topics: Aminobutyrates; Bemegride; Benzene; Calcium; Central Nervous System Stimulants; Chlorides; Coronary | 1964 |
ALTERATIONS IN THE ACTIVITY OF PENTOTHAL, PHENOBARBITAL, PENTYLENETETRAZOL, AND STRYCHNINE BY CHOLINESTERASE INHIBITORS.
Topics: Acetylcholine; Anesthesia; Atropine; Cholinesterase Inhibitors; Isoflurophate; Mice; Neostigmine; Pe | 1964 |
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy, | 1964 |
NON-PARTICIPATION OF BLOOD-CEREBROSPINAL FLUID-BARRIER IN THE DEVELOPMENT OF TOLERANCE TO THE ANALGESIC EFFECT OF MORPHINE IN MICE.
Topics: Analgesics; Blood-Brain Barrier; Drug Tolerance; Electricity; Electroshock; Mice; Morphine; Pentylen | 1964 |
[CHANGES IN THE COURSE OF CORAZOLE CONVULSIONS DUE TO VARIOUS DOSES OF TOTAL-BODY ROENTGEN IRRADIATION].
Topics: Anti-Infective Agents, Local; Pentylenetetrazole; Pharmacology; Radiation Effects; Rats; Research; S | 1964 |
EFFECTS OF BRAINSTEM AND SUBCORTICAL LESIONS ON CORTICOGENIC EPILEPTIC CONVULSION WITH SPECIAL REFERENCE TO FOREL H-FIELD.
Topics: Brain Diseases; Brain Stem; Cats; Cerebral Cortex; Electroencephalography; Electromyography; Epileps | 1964 |
CHLOROPHENOTHANE (DDT) AND GLUTAMINE IN PENTYLENETETRAZOLE (CARDIAZOLE) CONVULSIONS IN THE RAT.
Topics: DDT; Glutamine; Metabolism; Pentylenetetrazole; Pharmacology; Rats; Research; Seizures | 1964 |
ELECTROCONVULSIVE RESPONSES OF RATS TO CONVULSANT AND ANTICONVULSANT DRUGS DURING HIGH-ALTITUDE ACCLIMATIZATION.
Topics: Acclimatization; Acetazolamide; Altitude; Anticonvulsants; Convulsants; Electricity; Electroshock; P | 1964 |
INTRACELLULAR POTENTIALS ASSOCIATED WITH DIRECT CORTICAL RESPONSE AND SEIZURE DISCHARGE IN CAT.
Topics: Brain; Cats; Cerebral Cortex; Electrophysiological Phenomena; Electrophysiology; Pentylenetetrazole; | 1964 |
CERTAIN PHARMACOLOGICAL PROPERTIES OF 3-ETHYL-2-METHYL-2-PHENYLSUCCINIMIDE.
Topics: Anticonvulsants; Mental Disorders; Meprobamate; Mice; Pentylenetetrazole; Peptic Ulcer; Pharmacology | 1964 |
R. S. (P) A NEW ISOLATE FROM THE ROOT OF RAUWOLFIA SERPENTINA, BENTH.
Topics: Alkaloids; Animals; Blood Pressure; Blood Pressure Determination; Cats; Central Nervous System; Elec | 1964 |
THE EFFECT OF METRAZOL ON THE HEMODYNAMICS AND IMPEDANCE OF THE CAT'S BRAIN CORTEX.
Topics: Blood Flow Velocity; Brain; Cats; Cerebral Cortex; Cerebrovascular Circulation; Electric Impedance; | 1965 |
[ANTIEPILEPTIC ACTIVITIES OF A NEW COMPOUND, ETHOXYCARBODIPHENYLHYDANTOIN].
Topics: Animals; Anticonvulsants; Hydantoins; Mice; Pentylenetetrazole; Pharmacology; Rats; Research; Seizur | 1964 |
[POSTCONVULSIVE CHANGES IN BLOOD SUGAR IN THE RAT].
Topics: Blood Glucose; Hyperglycemia; Pentylenetetrazole; Pharmacology; Rats; Research; Seizures | 1964 |
[FURTHER STUDIES ON THE PROBLEM OF RECIPROCAL INTERRELATIONS BETWEEN NORADRENALIN AND SEROTONIN].
Topics: Animals; Drug Synergism; Mice; Norepinephrine; Pentylenetetrazole; Pharmacology; Research; Seizures; | 1964 |
EFFECT OF TYPE OF BEDDING MATERIAL ON THRESHOLDS OF PENTYLENETETRAZOL CONVULSIONS IN MICE.
Topics: Animals, Laboratory; Bedding and Linens; Laboratories; Mice; Pentylenetetrazole; Pharmacology; Resea | 1965 |
INCREASED SENSITIVITY TO PENTYLENETETRAZOL AND FLUROTHYL FOLLOWING CORTICAL ABLATIONS IN RATS.
Topics: Central Nervous System Stimulants; Cerebral Cortex; Cerebral Decortication; Flurothyl; Pentylenetetr | 1965 |
EFFECTS OF CORTICAL SPREADING DEPRESSION AND DRUGS UPON AUDIOGENIC SEIZURES IN RATS.
Topics: Brain; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Epilepsy; Epilepsy, Reflex | 1965 |
[STUDY OF THE PLASMA AND CEREBRAL ELECTROLYTES IN THE NORMAL RABBIT AND DURING PENTETRAZOLE*-INDUCED CONVULSIONS].
Topics: Animals; Brain Chemistry; Electrolytes; Lagomorpha; Metabolism; Pentylenetetrazole; Plasma; Rabbits; | 1964 |
CENTRAL STIMULANT ACTIONS OF ALPHA-ALKYL SUBSTITUTED TRYPTAMINES IN MICE.
Topics: Body Temperature; Brain; Carboxy-Lyases; Central Nervous System Stimulants; Indoles; Injections, Int | 1965 |
HEXAFLUORODIETHYL ETHER (INDOKLON) CONVULSIONS IN CORPUS-CALLOTOMIZED WHITE RATS.
Topics: Brain; Corpus Callosum; Drug Tolerance; Ether; Ethers; Flurothyl; Hypoxia, Brain; Pentylenetetrazole | 1964 |
THE GENERALIZATION OF A SEIZURE.
Topics: Animals; Brain; Electrophysiological Phenomena; Electrophysiology; Haplorhini; Humans; Penicillins; | 1965 |
BRAIN STRUCTURES AND ORIGIN OF CONVULSIONS CAUSED BY HIGH OXYGEN PRESSURE (HOP).
Topics: Atropine; Brain; Cats; Electroencephalography; Hyperbaric Oxygenation; Nervous System Physiological | 1964 |
[THE EFFECT OF VARIOUS NOXIOUS STIMULI ON THE BLOOD-BRAIN BARRIER. II. THE EFFECT OF CARDIAZOL CONVULSION ON THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER TO DIFFERENT TRACER SUBSTANCES IN RATS AND RABBITS].
Topics: Animals; Biological Transport; Blood-Brain Barrier; Pentylenetetrazole; Permeability; Rabbits; Radio | 1965 |
REPEATED ELECTROCONVULSIONS RESULTING IN ELEVATION OF PENTYLENETETRAZOLE SEIZURE THRESHOLD.
Topics: Brain; Cats; Drug Tolerance; Electric Stimulation; Electrophysiology; Electroshock; Pentylenetetrazo | 1965 |
THE ANTICONVULSANT ACTIVITY OF HYDROXYLAMINE.
Topics: Anticonvulsants; Electric Stimulation; Electroshock; Hydroxylamine; Hydroxylamines; Isoniazid; Morta | 1965 |
[Action of some phenothiazine derivatives on the effects of convulsant agents].
Topics: Antipsychotic Agents; Barbiturates; Chlorpromazine; Convulsants; Pentylenetetrazole; Phenothiazines; | 1955 |
Effect of variations in extracellular sodium concentration on the susceptibility of mice to pentylenetetrazole (metrazol)-induced seizures.
Topics: Animals; Blood; Disease Susceptibility; Mice; Pentylenetetrazole; Seizures; Sodium | 1955 |
Pentylenetetrazol seizure activity in mice as influenced by route of administration, acute adrenalectomy and reserpine.
Topics: Adrenalectomy; Animals; Mice; Pentylenetetrazole; Reserpine; Seizures | 1960 |
The effect of tranquilizers on the convulsant effect of strychnine, pentylenetetrazol and aminopyrine.
Topics: Aminopyrine; Convulsants; Pentylenetetrazole; Seizures; Strychnine; Tranquilizing Agents | 1959 |
[Changes in the cardiac output and in the pulmonary blood volume during cardiazol shock].
Topics: Blood Volume; Cardiac Output; Heart; Humans; Lung; Pentylenetetrazole; Seizures; Shock | 1961 |
[The modification of the pentetrazole convulsive threshold by the intracerebral injection of reserpine and biogenic amines].
Topics: Biogenic Amines; Epinephrine; Injections; Norepinephrine; Pentylenetetrazole; Reserpine; Seizures; S | 1962 |
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; F | 2003 |
Evidence for a selective role of the delta-opioid agonist [8R-(4bS*,8aalpha,8abeta, 12bbeta)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline hydrochloride (SB-23586
Topics: Animals; Binding, Competitive; Carrageenan; Cells, Cultured; Convulsants; Cyclic AMP; Electroshock; | 2003 |
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
Topics: Acetyltransferases; Animals; Biogenic Polyamines; Brain; Cell Count; Crosses, Genetic; Dose-Response | 2003 |
Electromagnetic waves of 900 MHz in acute pentylenetetrazole model in ontogenesis in mice.
Topics: Age Factors; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Radiation; Ma | 2003 |
Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3).
Topics: alpha-Linolenic Acid; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Disease Models, | 2004 |
Adult-born hippocampal neurons mature into activity-dependent responsiveness.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cellular Senescence; Fem | 2003 |
Influence of sexual hormone antagonists on the anticonvulsant action of conventional antiepileptic drugs against electrically- and pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Drug Synergism; Drug Therapy, Combination; Electroshock; Female; Gonadal S | 2004 |
Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats.
Topics: Animals; Dose-Response Relationship, Drug; Imidazoles; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2003 |
Elevation of corazol-induced seizure threshold after active immunization of mice of various genetic strains with glutamate-bovine serum albumin conjugate.
Topics: Animals; Anticonvulsants; Cattle; Convulsants; Glutamic Acid; Glutamine; Immunization; Mice; Mice, I | 2003 |
Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats.
Topics: Animals; Brain Stem; Electroshock; Epilepsy, Reflex; Immunohistochemistry; Pentylenetetrazole; Prose | 2004 |
Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice.
Topics: Animals; Anticonvulsants; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Co | 2003 |
Synthesis and anticonvulsant activity of some new dioxolane derivatives.
Topics: Animals; Anticonvulsants; Dioxolanes; Drug Evaluation, Preclinical; Electric Stimulation; Electrosho | 2003 |
Inhibitory effects of recombinant neurotoxin BmK IM on seizures induced by pentylenetetrazol in Rats.
Topics: Animals; Glutamine; Hippocampus; Male; Microinjections; Pentylenetetrazole; Peptides; Rats; Rats, Sp | 2003 |
Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain.
Topics: Animals; Anticonvulsants; Body Weight; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutam | 2003 |
Calorie restriction may not elevate the threshold of PTZ-induced seizures.
Topics: Animals; Caloric Restriction; Pentylenetetrazole; Rats; Seizures | 2003 |
Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.
Topics: Animals; Behavior, Animal; Body Weight; Convulsants; Eating; Environment; Gene Targeting; Locomotion | 2004 |
Spatiotemporal changes of the N-methyl-D-aspartate receptor subunit levels in rats with pentylenetetrazole-induced seizures.
Topics: Animals; Brain; Gene Expression Regulation; Male; Pentylenetetrazole; Protein Subunits; Rats; Rats, | 2004 |
Anticonvulsant profile of flunarizine and relation to Na(+) channel blocking effects.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2004 |
Intestinal inflammation alters the susceptibility to pentylenetetrazole-induced seizure in mice.
Topics: Animals; Convulsants; Enteritis; Male; Mice; Naltrexone; Pentylenetetrazole; Seizures | 2004 |
Induced seizures as therapy of experimental strokes in dogs.
Topics: Animals; Blood Pressure; Brain; Carotid Stenosis; Convulsants; Disease Models, Animal; Dogs; Electri | 1971 |
Design and synthesis of semicarbazones and their bio-isosteric analogues as potent anticonvulsants: the role of hydrogen bonding.
Topics: Administration, Oral; Animals; Anticonvulsants; Drug Design; Electroshock; Female; Hydrogen Bonding; | 2003 |
Experiences with combined stroboscopic and metrazol activation of the EEG in epileptics and in patients suspected of having seizures (Gastaut technique).
Topics: Electroencephalography; Epilepsy; Humans; Pentylenetetrazole; Seizures; Stroboscopy | 1950 |
[Effect of cardiazol, coramine and pyramidon on the electroencephalogram and electromyelogram in cats and rabbits].
Topics: Aminopyrine; Animals; Cats; Electroencephalography; Lagomorpha; Nikethamide; Pentylenetetrazole; Rab | 1950 |
[Modifications in the electroencephalogram during experimental convulsions produced by injections of cardiazol in divided dosage].
Topics: Electroencephalography; Injections; Pentylenetetrazole; Seizures | 1950 |
[Potentials derived from the cerebral cortex and from the spinal cord in the curarized dog under the influence of cardiazol].
Topics: Animals; Cerebral Cortex; Dogs; Leadership; Pentylenetetrazole; Seizures; Spinal Cord | 1950 |
Electrographic changes immediately recorded from the exposed human brain during cardiazol convulsion.
Topics: Brain; Convulsive Therapy; Humans; Pentylenetetrazole; Seizures | 1950 |
[Convulsion in adult and young dogs after administration of cardiazol].
Topics: Pentylenetetrazole; Seizures | 1950 |
Effects of various concentrations of adrenocorticotrophic hormone on electrical activity of brain and on sensitivity to convulsion-inducing agents.
Topics: Adrenocorticotropic Hormone; Brain; Nervous System Physiological Phenomena; Pentylenetetrazole; Seiz | 1952 |
[Experimental studies on the prolongation of convulsions by oxygen and epinephrine; prolonged convulsions after single electric stimulation or cardiazol administration].
Topics: Electric Stimulation; Electroencephalography; Epinephrine; Oxygen; Pentylenetetrazole; Seizures | 1951 |
[Convulsions due to cardiazol in Hemicerebellectomized dogs].
Topics: Animals; Cerebellum; Dogs; Pentylenetetrazole; Seizures | 1951 |
[Effects of neoantergan on cardiazol convulsions on avertine narcosis].
Topics: Anti-Allergic Agents; Ethanol; Histamine H1 Antagonists; Pentylenetetrazole; Seizures; Stupor | 1951 |
Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice.
Topics: Animals; Anticonvulsants; Benzoquinones; Diazepam; Electroshock; Flumazenil; GABA Modulators; Inject | 2004 |
Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study.
Topics: Amines; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationsh | 2004 |
Valproic acid-hydrophilic cyclodextrin complexes and valproic acid-solid dispersions: evaluation of their potential pharmaceutical use.
Topics: Algorithms; Animals; Anticonvulsants; Calorimetry, Differential Scanning; Chromatography, High Press | 2004 |
Effect of agmatine on electrically and chemically induced seizures in mice.
Topics: Agmatine; Animals; Convulsants; Dose-Response Relationship, Drug; Electroshock; Female; Male; Mice; | 2003 |
Effect of harmane on the convulsive threshold in epilepsy models in mice.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Female; Harmine; Male; Mice; P | 2003 |
Anticonvulsant activity of Schiff bases of isatin derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Female; Isatin; Lethal Dose 50; Magnetic Resona | 2004 |
Response of seizure-induced newborn neurons in the dentate gyrus of adult rats to second episode of seizures.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bromodeoxyuridine; Dentate Gyrus; Drug Administration S | 2004 |
Inhibitory effects of the essential oil from SuHeXiang Wan on the central nervous system after inhalation.
Topics: 4-Aminobutyrate Transaminase; Administration, Inhalation; Animals; Anticonvulsants; Antioxidants; Br | 2004 |
Effects of some synthetic kynurenines on brain amino acids and nitric oxide after pentylenetetrazole administration to rats.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Kynurenine; Male; Nitric Oxide; Pentylene | 2004 |
Metabolism of a new antiepileptic drug, N-methyl-tetramethylcyclopropanecarboxamide, and anticonvulsant activity of its metabolites.
Topics: Amides; Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Behavior, Animal; Biotransformation | 2004 |
Lipophilic 4-imidazoly-1,4-dihydropyridines: synthesis, calcium channel antagonist activity and protection against pentylenetetrazole-induced seizure.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dose-Response Relationship, D | 2004 |
Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol.
Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; Anticonvulsants; Carbolines; Convulsants; Dose- | 2004 |
Synthesis and evaluation of anticonvulsant and antimicrobial activities of 3-hydroxy-6-methyl-2-substituted 4h-pyran-4-one derivatives.
Topics: Animals; Anticonvulsants; Antifungal Agents; Candida albicans; Dose-Response Relationship, Drug; Ele | 2004 |
The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone.
Topics: alpha-Tocopherol; Analysis of Variance; Animals; Blotting, Western; Chromatography, High Pressure Li | 2004 |
Prolonged changes in Ca2+/calmodulin-dependent protein kinase II after a brief pentylenetetrazol seizure; potential role in kindling.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Ki | 2004 |
MAO(A) knockout mice are more susceptible to seizures but show reduced epileptogenesis.
Topics: Animals; Electric Stimulation; Epilepsy; Female; Kindling, Neurologic; Male; Mice; Mice, Inbred C3H; | 2004 |
Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2004 |
Anticonvulsant activity of Mimosa pudica decoction.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Medic | 2004 |
Neuropharmacological profile of hydroalcohol extract of Valeriana edulis ssp. procera roots in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, I | 2004 |
[Effect of alahistidine on brain histamine content and seizure development].
Topics: Animals; Brain Chemistry; Carnosine; Histamine; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley | 2004 |
[Effects between the first-and second-generation histamine H1-antagonists on seizure development of pentylenetetrazole-induced kindling in rats].
Topics: Animals; Histamine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Histidine; Kin | 2004 |
[Effects of pentylenetetrazol at subconvulsant and convulsant dose on NMDA receptor subunits in rats].
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Rats; Rats, Sp | 2004 |
The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors.
Topics: Adrenergic alpha-Agonists; Animals; Anticonvulsants; Autoreceptors; Clonidine; Convulsants; Guanfaci | 2004 |
Tolerance to pentylentetrazol-induced convulsions and protection of cerebrovascular integrity by chronic nicotine.
Topics: Analysis of Variance; Animals; Blood Pressure; Blood-Brain Barrier; Brain; Capillary Permeability; C | 2004 |
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Topics: Alleles; Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Codo | 2004 |
Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures.
Topics: Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Pent | 2004 |
Differential effect of cyclooxygenase-2 preferring [correction of prefering] inhibitors on electrically- and chemically-induced seizures in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electroshock; Fem | 2003 |
Continuous increase of epileptogenic effects following application of proteolytic enzymes (buccal ganglia of Helix pomatia).
Topics: Animals; Biological Clocks; Cheek; Convulsants; Disease Models, Animal; Enzymes; Epilepsy; Ganglia, | 2004 |
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Recepto | 2004 |
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Cyclopropanes; Electroshock; Mice; Pentylenetetrazole; Polyun | 2004 |
Valacyclovir treatment ameliorates the persistently increased pentylenetetrazol-induced seizure susceptibility in mice with herpes simplex virus type 1 infection.
Topics: Acyclovir; Animals; Antiviral Agents; Behavior, Animal; Body Weight; Disease Susceptibility; Dose-Re | 2004 |
Decreased expression of brain cAMP response element-binding protein gene following pentylenetetrazol seizure.
Topics: Animals; Brain; Cell Count; Convulsants; Cyclic AMP Response Element-Binding Protein; Cyclophilins; | 2004 |
Ionotropic glutamate receptor antagonists inhibit the proliferation of granule cell precursors in the adult brain after seizures induced by pentylenetrazol.
Topics: Animals; Cell Count; Cell Proliferation; Dentate Gyrus; Dizocilpine Maleate; Down-Regulation; Excita | 2004 |
Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil.
Topics: Animals; Anticonvulsants; Artemisia; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Oil | 2004 |
Sex and estrus cycle differences in the modulatory effects of morphine on seizure susceptibility in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Susceptibility; Dose-Response Relationship, Drug; Est | 2004 |
Increased seizure threshold and severity in young transgenic CRND8 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Male; Mice; Mice | 2004 |
Effects of nitric oxide on dentate gyrus cell proliferation after seizures induced by pentylenetrazol in the adult rat brain.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Division; Dentate Gyrus; Drug Interactions; Free Radica | 2004 |
Synthesis of some mono-Mannich bases and corresponding azine derivatives and evaluation of their anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aza Compounds; Convulsants; Electroshock; Indicators and Reagents; Mannich | 2004 |
Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation.
Topics: Animals; Apoptosis; Cell Cycle Proteins; Convulsants; Dizocilpine Maleate; Drug Synergism; Excitator | 2004 |
Effects of kyotorphin and analogues on nociception and pentylenetetrazole seizures.
Topics: Analgesics; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Endorphins; Male; Pain; P | 2004 |
Convulsant and anticonvulsant effects of bupropion in mice.
Topics: Animals; Anticonvulsants; Bupropion; Convulsants; Dose-Response Relationship, Drug; Electroshock; Ka | 2004 |
Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; gamma-Aminob | 2004 |
In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching.
Topics: Animals; Aquaporin 4; Aquaporins; Astrocytes; Brain Edema; Cerebral Cortex; Convulsants; Dextrans; D | 2004 |
Genetic and phenotypic analysis of seizure susceptibility in PL/J mice.
Topics: Animals; Convulsants; Crosses, Genetic; Disease Models, Animal; Electroencephalography; Electroshock | 2004 |
Electrocorticographic and electrochordographic study of the convulsions induced by cardiazol; some observations on the combined action of C.N.S. excitants.
Topics: Electroencephalography; Pentylenetetrazole; Seizures | 1950 |
[Use of succinylcholine diiodide in convulsion therapy with pentylenetetrazole].
Topics: Convulsive Therapy; Humans; Pentylenetetrazole; Seizures; Succinylcholine | 1954 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid.
Topics: Amides; Amygdala; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Dimethyl Sulfoxide; Dose-R | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Ascorbate modulates pentylenetetrazol-induced convulsions biphasically.
Topics: Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain Chemistry; Carbo | 2004 |
Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1.
Topics: Animals; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knocko | 2004 |
Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol.
Topics: Adenosine; Adenosine Diphosphate; Animals; Antigens, CD; Apyrase; Biomarkers; Brain; Convulsants; Di | 2004 |
Pharmacological effects of carcinine on histaminergic neurons in the brain.
Topics: Animals; Avoidance Learning; Brain; Carnosine; Convulsants; Dopamine; Histamine; Histidine Decarboxy | 2004 |
Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Co | 2004 |
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.
Topics: Androstane-3,17-diol; Animals; Aromatase Inhibitors; Chromatography; Convulsants; Dose-Response Rela | 2004 |
Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Convulsants; Darkness; Light; Male; | 2005 |
Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study.
Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Synergism; Electrophysiology; Hippocampus; Kynureni | 2004 |
Lithium inhibits the modulatory effects of morphine on susceptibility to pentylenetetrazole-induced clonic seizure in mice: involvement of a nitric oxide pathway.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Convulsants; Differential Threshold; Dose- | 2004 |
Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures.
Topics: Animals; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Syne | 2004 |
Magnetic resonance and biochemical studies during pentylenetetrazole-kindling development: the relationship between nitric oxide, neuronal nitric oxide synthase and seizures.
Topics: Analysis of Variance; Animals; Blotting, Southern; Blotting, Western; Brain; Brain Chemistry; Drug A | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, | 2005 |
Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anticonvulsants; Diestrus; Disease Models, Animal; Female; Hip | 2004 |
Studies of the roles of NMDA and AMPA glutamate receptors in the mechanism of corasole convulsions in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists | 2004 |
Investigation of the effects of tianeptine and fluoxetine on pentylenetetrazole-induced seizures in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Convulsants; Fe | 2005 |
The effect of fluoxetine in a model of chemically induced seizures--behavioral and immunocytochemical study.
Topics: Animals; Drug Interactions; Drug Synergism; Fluoxetine; Hippocampus; Immunohistochemistry; Male; Pen | 2005 |
Assessment of neurotoxicity induced by oral administration of chlordecone (Kepone) in the mouse.
Topics: Animals; Body Weight; Chlordecone; Convulsants; Dose-Response Relationship, Drug; Drinking; Eating; | 1981 |
Synthesis and pharmacological evaluation of some DL-dichlorophenyl alcohol amides anticonvulsants.
Topics: Amides; Animals; Anticonvulsants; Convulsants; Hydrocarbons, Chlorinated; Magnetic Resonance Spectro | 2004 |
Intrinsic neural circuits between dorsal midbrain neurons that control fear-induced responses and seizure activity and nuclei of the pain inhibitory system elaborating postictal antinociceptive processes: a functional neuroanatomical and neuropharmacologi
Topics: Adrenergic Antagonists; Animals; Biogenic Monoamines; Fear; Inferior Colliculi; Locus Coeruleus; Mal | 2005 |
Anticonvulsant and neurotoxicity evaluation of some 6-substituted benzothiazolyl-2-thiosemicarbazones.
Topics: Animals; Anticonvulsants; Convulsants; Drug Evaluation, Preclinical; Male; Mice; Motor Activity; Pen | 2005 |
Anticonvulsant activity of ginseng on seizures induced by chemical convulsants.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Administration | 2005 |
Blockade of the membranal GABA transporter potentiates GABAergic responses evoked in pyramidal cells by mossy fiber activation after seizures.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Anta | 2005 |
Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice.
Topics: Animals; Antioxidants; Biomarkers; Caffeic Acids; Central Nervous System; Convulsants; Female; Malon | 2004 |
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous Syst | 2005 |
Antinociceptive activity of new imidazolidine carbonyl derivatives. Part 4. Synthesis and pharmacological activity of 8-aryl-3,4-dioxo-2H,8H-6,7-dihydroimidazo[2,1-c] [1,2,4]triazines.
Topics: Amides; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Carbonic Acid; Cyclization; Imida | 2005 |
Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures.
Topics: Animals; Behavior, Animal; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Administrati | 2005 |
Anti-epileptogenic effect of beta-carotene and vitamin A in pentylenetetrazole-kindling model of epilepsy in mice.
Topics: Animals; Anticonvulsants; beta Carotene; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2005 |
Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relation | 2005 |
Anticonvulsant effect of Hypericum perforatum: role of nitric oxide.
Topics: Animals; Anticonvulsants; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2005 |
Anticonvulsant activity of Heracleum persicum seed.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2005 |
Influence of low dietary histamine on seizure development of chemical kindling induced by pentylenetetrazol in rats.
Topics: Animals; Brain; Diet; Histamine; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2005 |
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.
Topics: Animals; Anxiety; Ataxia; Behavior, Animal; Benzodiazepines; Body Temperature; Body Weight; Cerebell | 2005 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, In | 2005 |
Behavioural phenotypes of hypomorphic KCC2-deficient mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Blotting, Wester | 2005 |
Study of antiepileptic effect of extracts from Acorus tatarinowii Schott.
Topics: Acorus; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroshock; Epilepsy; gamma-Amino | 2005 |
Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chlorides; Disease Mo | 2005 |
Pentylenetetrazole-induced convulsions affect cellular and molecular parameters of the mechanism of action of triiodothyronine in adult rat brain.
Topics: Animals; Blotting, Northern; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Female; Gen | 2005 |
Erdosteine ameliorates PTZ-induced oxidative stress in mice seizure model.
Topics: Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Convulsants; Disease Models, Animal; Dru | 2005 |
A pentylenetetrazole-induced generalized seizure in early life enhances the efficacy of muscarinic receptor coupling to G-protein in hippocampus and neocortex of adult rat.
Topics: Animals; Autoradiography; Drug Interactions; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotri | 2005 |
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Diazepam; Drug Design; Electroshock; Flumaze | 2005 |
Amino acid levels in some lethargic mouse brain areas before and after pentylenetetrazole kindling.
Topics: Amino Acids; Animals; Brain; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; S | 2005 |
Immunization with the glutamate receptor-derived peptide GluR3B induces neuronal death and reactive gliosis, but confers partial protection from pentylenetetrazole-induced seizures.
Topics: Animals; Autoantibodies; Brain; Cell Count; Cell Death; Doublecortin Domain Proteins; Female; Gene P | 2005 |
Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice.
Topics: Adenosine Deaminase; Analysis of Variance; Animals; Anticonvulsants; Antioxidants; Dose-Response Rel | 2005 |
Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Convulsants; Dizocilpine Maleat | 2005 |
Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2005 |
Target-specific catecholamine elevation induced by anticonvulsant thalamic deep brain stimulation.
Topics: Animals; Brain; Catecholamines; Chromatography, High Pressure Liquid; Deep Brain Stimulation; Diseas | 2005 |
Amiloride protects against pentylenetetrazole-induced kindling in mice.
Topics: Amiloride; Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindli | 2005 |
Synthesis and anticonvulsant activity of some new hexahydropyrimidine-2,4-dione derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Indicators and Reagents; Injections, Intraperit | 2005 |
Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Equisetum; Female; Hypnotics and Sedativ | 2005 |
The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analysis of Variance; Animals; Anticonvulsants; Dose-Respons | 2005 |
Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application.
Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Electroencephalography; Male; Pentylenetetrazole; Purin | 2005 |
Synthesis and biological evaluation of new N-substituted-N'-(3,5-di/1,3,5-trimethylpyrazole-4-yl)thiourea/urea derivatives.
Topics: Animals; Anticonvulsants; Electroshock; Female; Male; Mice; Pentylenetetrazole; Seizures; Structure- | 2005 |
5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anticonvulsants; Con | 2005 |
Repeated administration of group I mGluR antagonists prevents seizure-induced long-term aberrations in hippocampal synaptic plasticity.
Topics: Analysis of Variance; Animals; Benzoates; Dose-Response Relationship, Radiation; Drug Interactions; | 2005 |
Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Exci | 2005 |
The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Disease Models, Animal; Dopamine beta- | 2006 |
Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats.
Topics: Allylamine; Analysis of Variance; Animals; Animals, Newborn; Diet; Disease Models, Animal; Drug Comb | 2005 |
A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats.
Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Blood Glucose; Body Weight; Dietary Fats; Disease Model | 2005 |
Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Estrogens; Female; Hippocampus | 2005 |
Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects.
Topics: Agmatine; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interac | 2005 |
Toxicological and pharmacological effects of D-arginine.
Topics: Adrenergic beta-Antagonists; Animals; Arginine; Autonomic Nervous System; Behavior, Animal; Betameth | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2005 |
Involvement of prostaglandins in an animal model of Shigella-related seizures.
Topics: Animals; Chi-Square Distribution; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Disease Models | 2005 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Ther | 2005 |
[Anticonvulsant effect of phencynonate hydrochloride on maximal electroshock seizure and the metrazol seizure threshold test in mice].
Topics: Animals; Animals, Newborn; Anticonvulsants; Aza Compounds; Cells, Cultured; Electroshock; Female; Gl | 2005 |
Synthesis of and pharmacological studies on the antidepressant and anticonvulsant activities of some 1,3,5-trisubstituted pyrazolines.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Convulsants; Electroshock; Indicators and Reagents; | 2005 |
Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanisms.
Topics: Animals; Anticonvulsants; Aza Compounds; Behavior, Animal; Brain Chemistry; Cells, Cultured; Choline | 2005 |
An experimental evaluation of anticonvulsant activity of Vitex-negundo.
Topics: Animals; Anticonvulsants; Drug Combinations; Drug Evaluation, Preclinical; Drug Interactions; Electr | 2005 |
Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions.
Topics: Alcohol Withdrawal Seizures; Animals; Anxiety; Ethanol; Female; Hyperkinesis; Male; Mice; Motor Acti | 2005 |
Prolonged exposure to lead lowers the threshold of pentylenetetrazole-induced seizures in rats.
Topics: Air Pollutants; Animals; Dose-Response Relationship, Drug; Drinking; Lead; Male; Pentylenetetrazole; | 2005 |
The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.
Topics: Alleles; Amygdala; Animals; Brain-Derived Neurotrophic Factor; Convulsants; Electric Stimulation; El | 2005 |
[Pentylenetetrazole kindling in rats: whether neurodegeneration is associated with manifestations of seizure activity?].
Topics: Animals; Convulsants; Hippocampus; Kindling, Neurologic; Male; Nerve Degeneration; Oxidative Stress; | 2005 |
Nitric oxide involvement in seizures elicited by pentylentetrazol and sex dependence.
Topics: Analysis of Variance; Animals; Drug Interactions; Enzyme Inhibitors; Female; Male; NG-Nitroarginine | 2005 |
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodi | 2005 |
Pentylenetetrazole kindling induces neuronal cyclin B1 expression in rat hippocampus.
Topics: Animals; Behavior, Animal; Cell Count; Cell Death; Cyclin B; Cyclin B1; Disease Models, Animal; Dose | 2006 |
Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats.
Topics: Affective Symptoms; Animals; Behavior, Animal; Convulsants; Disease Models, Animal; Hippocampus; Kin | 2005 |
Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice.
Topics: Animals; Anticonvulsants; Carotenoids; Crocus; Cyclohexenes; Mice; Pentylenetetrazole; Seizures; Ter | 2005 |
Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Female; Mice; Mice, Knockout; P | 2006 |
Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam.
Topics: Animals; Anticonvulsants; Convulsants; Electric Stimulation; Electrodes, Implanted; Electroencephalo | 2005 |
Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the central nervous system.
Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme Activation | 2006 |
Systemic administration of antibodies to glutamate increases seizure threshold for pentylenetetrazole.
Topics: Animals; Antibodies; Anticonvulsants; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Pentylenetetraz | 2005 |
[Effects of immunoglobulin on the neuronal expression of IL-1beta and IL-1ra and the neuronal death at hippocampus in rats with convulsion induced by pentylenetetrazol].
Topics: Animals; Apoptosis; Hippocampus; Immunoglobulins, Intravenous; Interleukin 1 Receptor Antagonist Pro | 2005 |
HuR mRNA ligands expressed after seizure.
Topics: Animals; Antigens, Surface; Convulsants; ELAV Proteins; ELAV-Like Protein 1; Gene Library; Hippocamp | 2005 |
Erythropoietin prevents the increase in blood-brain barrier permeability during pentylentetrazol induced seizures.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Convulsants; Disease Models, Animal; Drug Anta | 2006 |
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold.
Topics: Animals; Antiporters; Bicuculline; Brain; Chloride-Bicarbonate Antiporters; Convulsants; Dentate Gyr | 2006 |
Site-specific phosphorylation of SCG10 in neuronal plasticity: role of Ser73 phosphorylation by N-methyl D-aspartic acid receptor activation in rat hippocampus.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cells, Cultured; Dizocilpine Maleate; Dose-Response | 2006 |
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male | 2005 |
The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inh | 2005 |
Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Drug Therapy, Com | 2006 |
[Pathological changes of brain at different maturational stages caused by pentylenetetrazol-induced repeated seizure in rat models].
Topics: Age Factors; Animals; Hippocampus; NF-kappa B; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2005 |
Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae).
Topics: Analgesics; Animals; Anticonvulsants; Convulsants; Female; Kalanchoe; Male; Mice; Pentylenetetrazole | 2006 |
Effects of lipopolysaccharide on blood-brain barrier permeability during pentylenetetrazole-induced epileptic seizures in rats.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Convulsants; Escherichia coli; Evans Blue; Immunohisto | 2006 |
Long-term L-NAME treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Convulsants; Drug Synergism; Enzyme Inhibitors; Evans | 2006 |
Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses.
Topics: Animals; Anticonvulsants; Binding, Competitive; Convulsants; Dose-Response Relationship, Drug; Fluni | 2006 |
Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; | 2006 |
Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Central Nervous System Depressants; Ethanol; | 2006 |
Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice.
Topics: Animals; Benzene Derivatives; Brain; Chelating Agents; Convulsants; Dimercaprol; Disease Models, Ani | 2006 |
Menhaden fish oil improves spatial memory in rat pups following recurrent pentylenetetrazole-induced seizures.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Corn Oil; Fatty Acids; Fish Oils; Maze Learning; | 2006 |
The proconvulsant effect of sildenafil in mice: role of nitric oxide-cGMP pathway.
Topics: Animals; Arginine; Bicuculline; Cyclic GMP; Dose-Response Relationship, Drug; Male; Methylene Blue; | 2006 |
Alterations in long-term seizure susceptibility and the complex of PSD-95 with NMDA receptor from animals previously exposed to perinatal hypoxia.
Topics: Animals; Animals, Newborn; Brain; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease M | 2006 |
Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat.
Topics: Animals; Carnosine; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Histamine | 2006 |
GM1 ganglioside prevents seizures, Na+,K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole.
Topics: Animals; Convulsants; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists | 2006 |
The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol.
Topics: Animals; Behavior, Animal; Benzamides; Dose-Response Relationship, Drug; Electrodes; Electroencephal | 2006 |
Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding Sites; Brain; GABA Anta | 2006 |
Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics.
Topics: Alanine; Animals; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Convulsants; Dogs; Doripenem; | 2006 |
Effect of simultaneous insertion of oleaginous base on the absorption and on the anticonvulsant effect of diazepam suppository.
Topics: Animals; Anticonvulsants; Area Under Curve; Convulsants; Diazepam; Dose-Response Relationship, Drug; | 2006 |
Evaluation of the central activity of hydroxydihydrocarvone.
Topics: Analgesics; Analgesics, Opioid; Animals; Anticonvulsants; Central Nervous System Agents; Convulsants | 2006 |
Synthesis and evaluation of antimicrobial and anticonvulsant activities of some new 3-[2- (5-aryl-1,3,4-oxadiazol-2-yl/4-carbethoxymethylthiazol-2-yl) imino-4-thiazolidinon-5-ylidene]-5-substituted/nonsubstituted 1H-indole-2-ones and investigation of thei
Topics: Anti-Infective Agents; Anticonvulsants; Antifungal Agents; Bacteria; Fungi; Gas Chromatography-Mass | 2006 |
Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency.
Topics: Animals; Brain; Deficiency Diseases; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred S | 2006 |
Anticonvulsant action of allopregnanolone in immature rats.
Topics: Age Factors; Anesthetics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injecti | 2006 |
Neuropharmacological effects of deltamethrin in rats.
Topics: Animals; Ataxia; Brain; Female; gamma-Aminobutyric Acid; Insecticides; Male; Molecular Structure; Ni | 2006 |
Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures.
Topics: Animals; Brain Mapping; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Abs | 2006 |
Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents.
Topics: Action Potentials; Acyclic Monoterpenes; Analysis of Variance; Animals; Anticonvulsants; Disease Mod | 2006 |
Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Anticonvulsants; Antioxidants; Aspartate Aminotransfe | 2006 |
Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Calcium Channels; Calcium Channels, T-Type; Disease Mod | 2006 |
Effects of chloroquine on GFAP, PCNA and cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole.
Topics: Animals; Cerebral Cortex; Chloroquine; Cyclin D1; Glial Fibrillary Acidic Protein; Hippocampus; Male | 2005 |
Effects of sparfloxacin on CNS functions and urinary hydroxyproline in mice.
Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Fluoroqu | 2006 |
Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.
Topics: Animals; Anticonvulsants; Benzamides; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; El | 2006 |
Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationsh | 2006 |
Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones.
Topics: Animals; Anticonvulsants; Binding Sites; Electroshock; Injections, Subcutaneous; Mice; Pentylenetetr | 2006 |
Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats.
Topics: alpha-Linolenic Acid; alpha-Tocopherol; Animals; Anticonvulsants; Kindling, Neurologic; Linoleic Aci | 2006 |
Synthesis and anticonvulsant activity of new N-1',N-3'-disubstituted-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones.
Topics: Animals; Anticonvulsants; Benzofurans; Imidazolidines; Mice; Molecular Structure; Pentylenetetrazole | 2006 |
Pentylenetetrazol kindling in rats: Is neurodegeneration associated with manifestations of convulsive activity?
Topics: Animals; Cell Count; Convulsants; Hippocampus; Kindling, Neurologic; Male; Nerve Degeneration; Neuro | 2006 |
Involvement of 5-HT(2) serotonergic receptors of the nucleus raphe magnus and nucleus reticularis gigantocellularis/paragigantocellularis complex neural networks in the antinociceptive phenomenon that follows the post-ictal immobility syndrome.
Topics: Analgesia; Analysis of Variance; Animals; Behavior, Animal; Brain; Male; Medulla Oblongata; Models, | 2006 |
Comparative efficacy of liposome-entrapped amiloride and free amiloride in animal models of seizures and serum potassium in mice.
Topics: Amiloride; Animals; Anticonvulsants; Convulsants; Diuretics; Dose-Response Relationship, Drug; Elect | 2007 |
Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action.
Topics: Animals; Anticonvulsants; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Disease Models, Animal; | 2006 |
The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction.
Topics: Animals; Convulsants; Cyclooxygenase Inhibitors; Diclofenac; Escherichia coli; Indomethacin; Lipopol | 2006 |
In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
Topics: Animals; Anticonvulsants; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; | 2006 |
The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated.
Topics: Alkynes; Animals; Benzodiazepines; Cells, Cultured; Convulsants; Female; Flumazenil; GABA Modulators | 2006 |
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis ele | 2006 |
Sex differences in steroid modulation of ethanol withdrawal in male and female rats.
Topics: Animals; Corticosterone; Estradiol; Ethanol; Female; Male; Neuroprotective Agents; Ovariectomy; Pent | 2007 |
Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Angiotensin II; Angiotensin II Type 1 Re | 2006 |
L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.
Topics: Animals; Cognition; Convulsants; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; Hippoca | 2006 |
Singing, but not seizure, induces synaptotagmin IV in zebra finch song circuit nuclei.
Topics: Animals; Behavior, Animal; Brain; Finches; Gene Expression Regulation; Immediate-Early Proteins; In | 2006 |
Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Convulsants; Electroshock; Furans; Magnetic Resonan | 2007 |
Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu.
Topics: Administration, Oral; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Erythrina; Glycine | 2007 |
Development of a Drosophila seizure model for in vivo high-throughput drug screening.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Cell Survival; Convulsants; Disease | 2006 |
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
Topics: Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Convulsants; Diazepam; Electroshock; GABA- | 2007 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behav | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Inte | 2006 |
Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling.
Topics: Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; | 2007 |
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2 Inhibitors; Drug Synergism; Drug Therapy, Combination; La | 2006 |
Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling.
Topics: Amino Acids; Animals; Brain; Convulsants; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Amino | 2006 |
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
Topics: Analgesics; Animals; Anticonvulsants; Benzhydryl Compounds; Benzyl Compounds; Binding, Competitive; | 2007 |
Participation of dihydrostyryl-2-pyrones and styryl-2-pyrones in the central effects of Polygala sabulosa (Polygalaceae), a folk medicine topical anesthetic.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Anti-Anxiety Agents; Anxiety; Convulsants; Dio | 2007 |
Dissociation between in vitro and in vivo epileptogenicity in a rat model of cortical dysplasia.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Freezing; | 2007 |
Resin glycosides from the roots of Ipomoea tyrianthina and their biological activity.
Topics: Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Glycolipids; Glycosides; Ileum; Ip | 2007 |
Pentylenetetrazol-kindling in mice overexpressing heat shock protein 70.
Topics: Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; HSP70 H | 2007 |
Carnosine inhibits pentylenetetrazol-induced seizures by histaminergic mechanisms in histidine decarboxylase knock-out mice.
Topics: Animals; Anticonvulsants; Carnosine; Dose-Response Relationship, Drug; Drug Interactions; Electroenc | 2007 |
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
Topics: Acetone; Animals; Anticonvulsants; Diet Therapy; Disease Models, Animal; Epilepsy; Ketone Bodies; Ma | 2007 |
Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Disease Models, Animal; Drug Interactions; Electro | 2007 |
Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Crassulaceae; Dose-Response Relationship, Drug; | 2007 |
Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Dose-Response Rela | 2007 |
[Long-term effects of recurrent seizures in neonate period on gamma-aminobutyric acid A receptor alpha1 and beta2 subunits expression in adult brain: experiment with rats].
Topics: Animals; Animals, Newborn; Brain; Cerebral Cortex; Disease Models, Animal; Flurothyl; Hippocampus; I | 2007 |
Historical perspective on PTZ-induced seizures.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Epilepsy, Generalized; History, 20th Century; Human | 2007 |
Effects of postnatal caffeine exposure on seizure susceptibility in developing rats.
Topics: Age Factors; Aminophylline; Animals; Animals, Newborn; Behavior, Animal; Bicuculline; Caffeine; Cent | 2007 |
[Involvement of endogenous histamine in modulatory effect of morphine on seizure susceptibility in mice].
Topics: Animals; Disease Susceptibility; Dose-Response Relationship, Drug; Histamine; Histidine Decarboxylas | 2007 |
Thalidomide inhibits pentylenetetrazole-induced seizures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2007 |
Evaluation of anticonvulsant activities of bis(3-aryl-3-oxo-propyl) ethylamine hydrochlorides and 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinol hydrochlorides.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Elements; Ethylamines; Indicators and Reagents; | 2007 |
Synthesis, physicochemical and anticonvulsant properties of new N-phenylamino derivatives of 2-azaspiro[4.4]nonane- and [4.5]decane-1,3-diones: part V.
Topics: Animals; Anticonvulsants; Aza Compounds; Electroshock; Mice; Pentylenetetrazole; Receptors, GABA-A; | 2008 |
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Convulsant | 2007 |
Central nervous system depressant activity of an ethyl acetate extract from Ipomoea stans roots.
Topics: Acetates; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Central Nervous Syst | 2007 |
Modified variant of the Rieske iron-sulfur protein in the hippocampus of kindled rats and human epileptic patients.
Topics: Animals; Electron Transport Complex III; Epilepsy; Hippocampus; Humans; Iron-Sulfur Proteins; Kindli | 2007 |
Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Ghrelin; Injections, Intrap | 2007 |
Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Cromakalim; Disease Models, Animal | 2007 |
Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Chi-Square Distribution; Depressive | 2007 |
A large-scale mutagenesis screen to identify seizure-resistant zebrafish.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Genetic Predisposition to Disease; Genetic Testin | 2007 |
Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition.
Topics: Animals; Astrocytes; Convulsants; Data Interpretation, Statistical; Electrophysiology; Excitatory Po | 2008 |
Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field.
Topics: Animals; Brain; Electricity; Electromagnetic Fields; Female; Mice; Pentylenetetrazole; Seizures; Sur | 2007 |
Synthesis and anticonvulsant activity of some novel 3-aryl amino/amino-4-aryl-5-imino-Delta2-1,2,4-thiadiazoline.
Topics: Animals; Anticonvulsants; Electroshock; Immobility Response, Tonic; Injections, Intraperitoneal; Mal | 2008 |
Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Electroencephalography; Electroshock; Epileps | 2007 |
Pentylentetrazol associated changes of hippocampal neurons in immature rats.
Topics: Animals; Convulsants; Dentate Gyrus; GABA Antagonists; Hippocampus; Histocytochemistry; Male; NADPH | 2007 |
Effect of systemic administration of adenosine on brain adenosine levels in pentylenetetrazol-induced seizure threshold in mice.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, | 2007 |
Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ('African potato') aqueous extract in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Hypoxis; Male; Mice; Mice, Inbred BALB C; Molecular Structure | 2008 |
Elevation of pentylenetetrazole-induced seizure threshold in cholestatic mice: interaction between opioid and cannabinoid systems.
Topics: Animals; Anticonvulsants; Bile Ducts; Cannabinoid Receptor Modulators; Cholestasis; Disease Models, | 2008 |
Gender difference in the influence of antioxidants on the blood-brain barrier permeability during pentylenetetrazol-induced seizures in hyperthermic rat pups.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Convulsants; Female; Fever; Male; Neuroprotective Agents | 2007 |
On the anticonvulsant activity of kaurenic acid.
Topics: Animals; Anticonvulsants; Bufo marinus; Cold Temperature; Disease Models, Animal; Diterpenes; Drug E | 2007 |
Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Ant | 2007 |
Pro-convulsant effect of cefazolin sodium against pentylenetetrazol- or picrotoxin-induced convulsions in mice.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Cefazolin; Convulsants; GABA-A Receptor Agonists; | 2007 |
Comparison of anticonvulsant effects of clorazepate dipotassium and diazepam. Four week anticonvulsant study in Rhesus monkeys.
Topics: Animals; Anticonvulsants; Clorazepate Dipotassium; Convulsants; Diazepam; Macaca mulatta; Pentylenet | 1974 |
Offsetting of aberrations associated with seizure proneness in rat hippocampus area CA1 by theta pulse stimulation-induced activity pattern.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Convulsants; Dat | 2007 |
Kindling in the early postnatal period: Effects on the dynamics of age-related changes in electrophysiological characteristics of hippocampal neurons.
Topics: Aging; Animals; Animals, Newborn; Convulsants; Data Interpretation, Statistical; Electrophysiology; | 2007 |
Evaluation of sphingolipids changes in brain tissues of rats with pentylenetetrazol-induced kindled seizures using MALDI-TOF-MS.
Topics: Animals; Brain; Brain Chemistry; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Sprague | 2007 |
Anticonvulsant action of GABA-B receptor agonist SKF97541 differs from that of baclofen.
Topics: Age Factors; Animals; Anticonvulsants; Baclofen; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Evaluat | 2008 |
Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection.
Topics: Analysis of Variance; Animals; Autoradiography; Cell Survival; Cells, Cultured; Cerebral Cortex; Emb | 2008 |
Embryonic exposure to domoic Acid increases the susceptibility of zebrafish larvae to the chemical convulsant pentylenetetrazole.
Topics: Animals; Behavior, Animal; Convulsants; Embryo, Nonmammalian; Female; Kainic Acid; Larva; Male; Micr | 2007 |
Effect of myo-inositol on convulsions induced by pentylenetetrazole and kainic acid in rats.
Topics: Animals; Anticonvulsants; Convulsants; Inositol; Kainic Acid; Pentylenetetrazole; Rats; Seizures | 2007 |
Anxiogenic and proconvulsant effect of gatifloxacin in mice.
Topics: Administration, Oral; Affect; Animals; Anti-Infective Agents; Anxiety; Behavior, Animal; Dose-Respon | 2008 |
Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids.
Topics: Animals; Body Weight; Brain; Chromatography, Gas; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatt | 2008 |
Synthesis and anticonvulsant activity of some N-phenyl-2-phtalimidoethanesulfonamide derivatives.
Topics: Animals; Anticonvulsants; Electroshock; Magnetic Resonance Spectroscopy; Male; Mice; Pentylenetetraz | 2007 |
The effect of progesterone on total brain tissue sialic acid levels in experimental epilepsy.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Epilepsy; Female; Kindling, Neurologic; Male; Mice | 2008 |
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism.
Topics: Adenine; Adenosine; Analysis of Variance; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Anim | 2008 |
Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.
Topics: Animals; Behavior, Animal; Central Nervous System Depressants; Ethanol; Female; GABA-A Receptor Anta | 2008 |
Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents.
Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2008 |
Anticonvulsant effects of leptin in epilepsy.
Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2008 |
Activation of seizures and electroencephalographic disturbances in epileptic and in control subjects with metrazol.
Topics: Electroencephalography; Epilepsy; Humans; Pentylenetetrazole; Seizures | 1948 |
Timed intravenous infusion of metrazol and strychnine for testing anticonvulsant drugs.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Intravenous; Pentylenetetrazole; Seizures; Strychnine | 1949 |
Evidence of cardiazol-anticonvulsant antagonism by electroencephalogram in rabbits.
Topics: Pentylenetetrazole; Seizures | 1948 |
Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Arousal; Cerebral Cortex; Dose-Response Relationship, | 2008 |
Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
Topics: Analysis of Variance; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response R | 2008 |
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Cholestasis; Corn Oi | 2008 |
Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model.
Topics: Animals; Brain; Disease Models, Animal; Ghrelin; Liver; Oxidative Stress; Pentylenetetrazole; Rats; | 2008 |
Effect of systemic treatment with antibodies against glutamate on the seizure response of C57Bl/6 mice after pentylenetetrazole kindling.
Topics: Animals; Antibodies; Anticonvulsants; Glutamic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred | 2007 |
Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electroencephalography; Leptin; Mic | 2008 |
Neuropharmacological effects in mice of Lychnophora species (Vernonieae, Asteraceae) and anticonvulsant activity of 4,5-di-O-[E]-caffeoylquinic acid isolated from the stem of L. rupestris and L. staavioides.
Topics: Analgesics; Animals; Anticonvulsants; Asteraceae; Dose-Response Relationship, Drug; Male; Mice; Mono | 2008 |
Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures.
Topics: Analysis of Variance; Animals; Antibodies; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; D | 2008 |
Effects interferon-2alpha on seizures in corasol-induced kindling.
Topics: Animals; Electroencephalography; Interferon-alpha; Kindling, Neurologic; Male; Pentylenetetrazole; R | 2007 |
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clon | 2008 |
Modulation of pentylenetetrazol-induced seizures by prostaglandin E2 receptors.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Pen | 2008 |
Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX.
Topics: Analysis of Variance; Animals; Ataxia; Behavior, Animal; Disease Models, Animal; Excitatory Amino Ac | 2008 |
Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset.
Topics: Animals; Behavior, Animal; Callithrix; Disease Models, Animal; Dose-Response Relationship, Drug; Fem | 2008 |
Rofecoxib potentiates the anticonvulsant effect of topiramate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2008 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; | 2008 |
Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electr | 2008 |
Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Female; Glial Fibrilla | 2008 |
Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures.
Topics: Acute Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dose-Response Relati | 2008 |
Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency.
Topics: Animals; Anticonvulsants; Aspartic Acid; Magnesium Chloride; Magnesium Deficiency; Male; Pentylenete | 2007 |
CNS depressive role of aqueous extract of Spinacia oleracea L. leaves in adult male albino rats.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Biogenic Monoamines; Central Nervous System; Dopami | 2008 |
Effect of propofol in altering pentylenetetrazol induced seizure threshold in rats.
Topics: Animals; Dose-Response Relationship, Drug; Pentylenetetrazole; Propofol; Rats; Rats, Wistar; Seizure | 2008 |
Antiseizure effects of 5*-androstane-3*,7beta-diol may be independent of actions at estrogen receptor beta.
Topics: Androstane-3,17-diol; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Estrogen R | 2008 |
Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol-induced seizure threshold in mice.
Topics: Adenosine; Animals; Anticonvulsants; Arginine; Convulsants; Cyclic AMP; Cyclic Nucleotide Phosphodie | 2008 |
Adenosine receptor agonists attenuate the development of diazepam withdrawal-induced sensitization in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarb | 2008 |
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Male; | 2008 |
Design and synthesis of 6-amino-1,4-oxazepane-3,5-dione derivatives as novel broad spectrum anticonvulsants.
Topics: Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Drug Design; Electroshock; Male; Mice; | 2008 |
Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine.
Topics: Analysis of Variance; Animals; Caffeine; Disease Models, Animal; Disease Susceptibility; Dose-Respon | 2008 |
Synthesis of DL-hydroxybenzenamides as anticonvulsants.
Topics: Animals; Anticonvulsants; Benzamides; Convulsants; Hydroxylation; Indicators and Reagents; Magnetic | 2008 |
The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoids; Convulsant | 2008 |
[Electron microscopic study of rabbit brains following convulsions experimentally induced with pentylenetrazol].
Topics: Animals; Cerebral Cortex; Electroencephalography; Male; Microscopy, Electron; Pentylenetetrazole; Ra | 1966 |
[Action of alpha-methyldopa on the convulsions and lethal effect of pentamethylenetetrazole in mice].
Topics: Animals; Death; Methyldopa; Mice; Pentylenetetrazole; Seizures; Time Factors | 1966 |
Responses of dogs to hyperoxic-, pentylenetetrazol-, and electroshock-induced convulsions.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebrospinal Fluid; Dogs; Electroconvulsive Therapy; Elect | 1967 |
A comparison of some central effects of morphine, morphinone and thebaine on rats and mice.
Topics: Animals; Electric Stimulation; Electroshock; Male; Morphine; Oxygen Consumption; Pentylenetetrazole; | 1967 |
Effects of convulsants on energy reserves in the cerebral cortex.
Topics: Animals; Centrifugation; Cerebral Cortex; Chlorpromazine; Electric Stimulation; Electroshock; Freezi | 1967 |
Effect of prolonged treatment with electroshock, metrazol, carnitine and anectine on the capillary permeability.
Topics: Animals; Capillary Permeability; Carnitine; Electric Stimulation; Electroshock; Female; Histamine; M | 1967 |
The effect of reserpine, alpha-methyl-m-tyrosine, prenylamine, and guanethidine on metrazol-convulsions and the brain monoamine level in mice.
Topics: Animals; Brain Chemistry; Dopamine; Enzymes; Fluorometry; Guanethidine; Methyltyrosines; Mice; Norep | 1967 |
The synthesis and tranquilizer activity of 2- and 4-substituted 3,5-morpholinediones.
Topics: Animals; Chemistry, Organic; Drug Antagonism; Glutethimide; Morpholines; Organic Chemistry Phenomena | 1967 |
Preparation and anticonvulsant activity of some aryldialkylsuccinimides.
Topics: Animals; Chemistry, Organic; Electric Stimulation; Electrophysiology; Electroshock; Organic Chemistr | 1967 |
The anticonvulsant activity of 4-alpha,8-alpha-naphthalenedicarboximide and its derivatives.
Topics: Animals; Behavior, Animal; Chemistry, Organic; Electric Stimulation; Electrophysiology; Electroshock | 1967 |
Free amino acids and glutamate decarboxylase activity in brain of mice during drug-induced convulsions.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Carboxy-Lyases; Glutamates; Glutam | 1967 |
Delay or inhibition of convulsions by intraperitoneal injections of diverse substances.
Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Brain Chemistry; Hypertonic Solutions; Injec | 1967 |
The effect of dieldrin (HEOD) on chronaxie and convulsion thresholds in rats and mice.
Topics: Animals; Chronaxy; Dieldrin; Dimethyl Sulfoxide; In Vitro Techniques; Mice; Nervous System; Pentylen | 1967 |
A comparison of the convulsant activity of procaine and pentylenetetrazol.
Topics: Animals; Anticonvulsants; Chlorpromazine; Dibenzylchlorethamine; Female; Hydroxybutyrates; Mice; Pen | 1967 |
Interrelation between convulsant drugs and x-irradiation on the central nervous system of rats.
Topics: Aging; Animals; Animals, Newborn; Central Nervous System; Male; Pentylenetetrazole; Radiation Effect | 1967 |
Puromycin effect on memory may be due to occult seizures.
Topics: Amnesia; Animals; Behavior, Animal; Brain; Cycloheximide; Drug Antagonism; Humans; Memory; Mice; Ner | 1967 |
Neuropharmacologic evaluation of 2-phenylimidazo-[1,2-a] pyrimidine hydrobromide (U-13,376B), an unusual strychnine antagonist.
Topics: Action Potentials; Anesthesia; Animals; Autonomic Agents; Cats; Caudate Nucleus; Chloralose; Decereb | 1967 |
A comparison of the anticonvulsant properties of l-propylhexedrine, phenobarbital and a salt-like complex of l-propylhexedrine and phenobarbital in mice and rats.
Topics: Animals; Anticonvulsants; Barbiturates; Behavior, Animal; Electroshock; Male; Mice; Pentylenetetrazo | 1967 |
[Action of radiations on the central nervous system. V. Changes in the convulsive threshold dose of some drugs].
Topics: Animals; Central Nervous System; Female; Male; Pentylenetetrazole; Procaine; Rabbits; Radiation Effe | 1967 |
Effects of temperature on convulsive liability of pentylenetetrazol, strychnine sulfate, and thebaine hydrochloride.
Topics: Animals; Body Temperature; Central Nervous System; Environmental Exposure; Male; Mice; Pentylenetetr | 1967 |
[The effect of cardiazol and strychnine in subconvulsant or convulsant doses on the cerebral blood flow].
Topics: Animals; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Hypothalamus; Mesence | 1967 |
Anticonvulsant actions of fominoben: possible involvement of benzodiazepine receptors.
Topics: 3-Mercaptopropionic Acid; Aminophylline; Animals; Anticonvulsants; Benzodiazepinones; Binding, Compe | 1984 |
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Toleranc | 1984 |
Forskolin suppresses seizures induced by pentylenetetrazol in mice.
Topics: Adenylyl Cyclases; Animals; Brain; Cerebellum; Colforsin; Cyclic AMP; Diterpenes; Enzyme Activation; | 1984 |
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxa | 1984 |
Brain cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Brain; Bucladesine; Cyclic AMP; Cyclic GMP; Diazepam; Dibutyryl Cyclic GMP | 1984 |
Interaction between delta-9-tetrahydrocannabinol and kindling by electrical and chemical stimuli in mice.
Topics: Animals; Dronabinol; Drug Interactions; Electric Stimulation; Electroshock; Kindling, Neurologic; Ma | 1984 |
Modification of pyrazoloquinolinone affinity by GABA predicts efficacy at the benzodiazepine receptor.
Topics: Animals; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Membra | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Amin | 1980 |
Central excitatory actions of flurazepam.
Topics: Animals; Behavior, Animal; Cats; Central Nervous System Stimulants; Dose-Response Relationship, Drug | 1980 |
Effect of repeated electroconvulsive shocks (ECS) on subthreshold doses of some CNS stimulants.
Topics: Animals; Central Nervous System Stimulants; Electroshock; Male; Mice; Pentylenetetrazole; Picrotoxin | 1980 |
Studies on the post-ictal rise in seizure threshold.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Electroshock; GABA Antagonists; Halothane | 1981 |
Atropine reversal of kainic acid-induced decrease in the leptazol convulsive threshold.
Topics: Animals; Atropine; Kainic Acid; Male; Mice; Parasympathetic Nervous System; Pentylenetetrazole; Pyrr | 1981 |
[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Th | 1981 |
Modulation of seizure pattern in the rat by neutral metabolites of indoleamines.
Topics: Animals; Brain; Indoles; Male; Pentylenetetrazole; Rats; Reserpine; Seizures; Time Factors | 1981 |
Changes in seizure susceptibility after successive treatments of mice with tryptophol and ethanol.
Topics: Alcoholism; Animals; Anticonvulsants; Brain; Brain Chemistry; Ethanol; Humans; Indoles; Male; Mice; | 1981 |
Potentiation of metrazol convulsions in chickens after neonatal injections of cycloheximide or glutamate.
Topics: Animals; Chickens; Cycloheximide; Dose-Response Relationship, Drug; Drug Synergism; Glutamates; Glut | 1982 |
Role of central beta-adrenoceptors in the control of pentylenetetrazol-induced convulsions in rats.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Female; Injections, Intraventricular; Male; P | 1982 |
Role of beta-adrenoceptors in the anticonvulsant effect of propranolol on leptazol-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Female; Male; Pentylenetetrazole; Propranolol; Rats; Rats, Inbred Strains; | 1982 |
Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Chlordiazepoxide; Clonazepam; Dose-Response Relationship, | 1982 |
Dose-dependence of the effect of hydralazine on the central nervous system in rats.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Hydralazine; Male; Pentylenetetra | 1983 |
An improved method for perfusion of the isolated brain of the rat-influence of perfusion conditions and application of analeptic and anticonvulsant drugs.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain; Central Nervous System Stimulants; Lactates | 1983 |
Thyroid hormones do not alter rat brain benzodiazepine receptor function in-vivo.
Topics: Animals; Brain; Pentylenetetrazole; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Thyr | 1983 |
Distinct behavioral and pharmacological effects of two benzodiazepine antagonists: Ro 15-1788 and methyl beta-carboline.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepinones; Carbolines; Cats; Drug Synergism; | 1983 |
Regulatory effects of neurotransmitters on electroshock and pentylenetetrazol seizures.
Topics: Adenosine; Animals; Brain; Dopamine; Electroshock; Neurotransmitter Agents; Norepinephrine; Pentylen | 1984 |
Plasma concentrations of clobazam and its N-desmethyl metabolite; protection against pentetrazol-induced convulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Injecti | 1984 |
Ionic and acid-base regulation of neurons and glia during seizures.
Topics: Acid-Base Equilibrium; Adenosine Triphosphatases; Animals; Anion Transport Proteins; Bicarbonates; C | 1984 |
Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Psychological; Diazepam; Drinking Beha | 1984 |
Abnormal behavioral effects elicited by a neurotropic mycotoxin, fumitremorgin A in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antiparkinson Agents; Antipsychotic Agents; Behavior, | 1984 |
Specific and non-specific multiple unit activities during pentylenetetrazol seizures. I. Animals with 'encéphale isolé'.
Topics: Action Potentials; Animals; Cats; Decerebrate State; Electroencephalography; Electromyography; Male; | 1980 |
Neuropharmacological effects of isomers of hexachlorocyclohexane. 1. Protection against pentylenetetrazol-induced convulsions.
Topics: Animals; Brain; Female; Hexachlorocyclohexane; Isomerism; Kinetics; Male; Molecular Conformation; Pe | 1981 |
Specific and non-specific multiple unit activities during pentylenetetrazol seizures in animals with mesencephalic transections.
Topics: Animals; Brain Stem; Cats; Cerebral Cortex; Diencephalon; Electroencephalography; Electromyography; | 1982 |
The role of the locus coeruleus in regulation of seizure susceptibility in rats.
Topics: Animals; Brain Chemistry; Electroshock; Hydroxyindoleacetic Acid; Locus Coeruleus; Male; Norepinephr | 1982 |
Push-pull perfusion of pentylenetetrazol in the brain stem of 'encéphale isolé' cats.
Topics: Animals; Brain Mapping; Brain Stem; Cats; Decerebrate State; Male; Mesencephalon; Pentylenetetrazole | 1983 |
Intracranial pressure during prolonged experimental convulsions in cats.
Topics: Animals; Bicuculline; Blood Pressure; Cats; Intracranial Pressure; Pentylenetetrazole; Seizures | 1983 |
[Antiepileptic effects of complex therapy with vitamins and anticonvulsant preparations (experimental findings)].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Therapy, Com | 1982 |
Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures.
Topics: Animals; Body Temperature; Chlordiazepoxide; Dose-Response Relationship, Drug; Dose-Response Relatio | 1983 |
Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Ceruletide; Cholecystokinin; Diazepam; Kinetics; Male; Mice; | 1980 |
Relationships between seizure activity and cyclic nucleotide levels in brain.
Topics: Animals; Behavior, Animal; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclic G | 1980 |
Dissimilar effects of nicotinamide and inosine, putative endogenous ligands of the benzodiazepine receptors, on pentylenetetrazol seizures in four strains of mice.
Topics: Animals; Anticonvulsants; Injections, Intraperitoneal; Injections, Intraventricular; Inosine; Ligand | 1980 |
Studies on AMP deaminase and 5'-nucleotidase in rat brain under different experimental conditions.
Topics: Ammonium Chloride; AMP Deaminase; Animals; Barbiturates; Brain; Enzyme Activation; Lithium; Nucleoti | 1980 |
beta-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Diazepam; Drug Synergism; Indoles; Membranes; Pent | 1980 |
Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Binding, Competitive; Diazepam; Hypoxanthines; Inosine; Kynurenine; Ligand | 1981 |
Effects of beta-endorphin on experimentally induced seizures in mice.
Topics: Animals; Behavior, Animal; beta-Endorphin; Electroshock; Endorphins; Mice; Pentylenetetrazole; Seizu | 1981 |
Benzodiazepine receptor increase following repeated pentylenetetrazole injections.
Topics: Animals; Brain; Male; Mice; Mice, Inbred DBA; Pentylenetetrazole; Receptors, Drug; Receptors, GABA-A | 1981 |
Oxidative metabolic responses with recurrent seizures in rat cerebral cortex: role of systemic factors.
Topics: Animals; Blood Pressure; Blood Volume; Cerebral Cortex; Electron Transport Complex IV; Oxidation-Red | 1981 |
Non-specific, non-selective and mild increase in the latency of pentylenetetrazol seizures produced by large doses of the putative endogenous ligands of the benzodiazepine receptor.
Topics: Animals; Hypoxanthines; Injections, Intraperitoneal; Injections, Intraventricular; Inosine; Ligands; | 1981 |
Effect of seizures kindled by subconvulsant doses of pentylenetetrazol on dopamine receptor binding and dopamine-sensitive adenylate cyclase in the rat.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; E | 1981 |
Rapid changes in cerebellar adenosine receptors following experimental seizures.
Topics: Adenosine; Animals; Cerebellum; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cel | 1981 |
Effect of acute and chronic pentylenetetrazol treatment on benzodiazepine and cholinergic receptor binding in rat brain.
Topics: Animals; Brain; Male; Pentylenetetrazole; Rats; Receptors, Cholinergic; Receptors, Drug; Receptors, | 1981 |
Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).
Topics: Animals; Bicuculline; Electroshock; GABA Antagonists; Kindling, Neurologic; Male; Pentylenetetrazole | 1982 |
The relationship between alpha 2-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Clonidine; Female; Male; Pentylenetetrazole; Prazosin; Ra | 1982 |
Relationships between norepinephrine and cyclic nucleotides in brain and seizure activity.
Topics: Animals; Brain; Cyclic AMP; Cyclic GMP; Drug Interactions; Mice; Norepinephrine; Pentylenetetrazole; | 1982 |
Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.
Topics: Animals; Behavior, Animal; Bicuculline; Body Temperature Regulation; Dose-Response Relationship, Dru | 1982 |
Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzodiazepinones; Conditioning, Operant; Dogs; Dose- | 1982 |
Biochemical aspects of pentylenetetrazole induced seizure.
Topics: Adenylyl Cyclases; Animals; Brain; Energy Metabolism; Glucose; Male; Pentylenetetrazole; Phosphoric | 1982 |
Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Flunitrazepam; Kinetics; Male; Membranes; Pent | 1982 |
Role of benzodiazepine receptors in seizures.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain; Diazepam; Hypoxanthines; Inosine; Mice; Penty | 1983 |
Effect of different convulsant drugs on some seizure parameters in morphine-dependent mice.
Topics: 3-Mercaptopropionic Acid; 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; Brain; Convulsants; | 1983 |
Roles of cyclic nucleotides in pathophysiologic mechanisms of seizures.
Topics: Animals; Brain; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Guinea Pigs; Hippocampus; In Vitro Techniqu | 1983 |
Potentiation by yohimbine of pentylenetetrazol-induced seizures in rats: role of alpha 2 adrenergic receptors.
Topics: Animals; Clonidine; Drug Synergism; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, | 1983 |
Convulsant drugs and changes in the electrical activity of the brain: an investigation of the effects of opioids on chemoconvulsions.
Topics: Animals; Brain; Convulsants; Electroencephalography; Electrophysiology; GABA Antagonists; Morphine; | 1983 |
Enhanced binding of radioligands to receptors of gamma-aminobutyric acid and benzodiazepine by a new anticonvulsive agent, LY81067.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric | 1983 |
The role of different types of adrenergic receptors in pentylenetetrazol-induced seizures and the effect of di-n-propylacetate in the rat.
Topics: Animals; Hydroxydopamines; Male; Oxidopamine; Pentylenetetrazole; Piperoxan; Rats; Receptors, Adrene | 1983 |
DMCM: a potent convulsive benzodiazepine receptor ligand.
Topics: Animals; Carbolines; Convulsants; Diazepam; Drug Interactions; Female; Indoles; Lorazepam; Male; Mic | 1983 |
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; F | 1983 |
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid; | 1983 |
Benzodiazepine inhibition of flunitrazepam receptor binding, adenosine uptake, and pentylenetetrazol-induced seizures in mice.
Topics: Adenosine; Animals; Benzodiazepines; Flunitrazepam; Male; Mice; Pentylenetetrazole; Receptors, Cell | 1984 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; M | 1984 |
Differential behavioral effects induced by intrathecal microinjection of opiates: comparison of convulsive and cataleptic effects produced by morphine, methadone, and D-Ala2-methionine-enkephalinamide.
Topics: Animals; Arousal; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Electroenceph | 1984 |
Synthesis of previously inaccessible quinazolines and 1,4-benzodiazepines as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Benzodiazepines; Mice; Pentylenetetrazole; Quinazolines; Receptors, Cell S | 1984 |
Proconvulsant action of CGS 8216.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Synergism; Flumazenil; Male; Mice; Pentylenetetrazole; | 1983 |
Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Drug Synerg | 1983 |
Studies on the role of serotonin in different regions of the rat central nervous system on pentylenetetrazol-induced seizures and the effect of di-n-propylacetate.
Topics: 5,7-Dihydroxytryptamine; Animals; Anticonvulsants; Brain; Male; Metergoline; Methysergide; Neurons; | 1983 |
The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains | 1983 |
The partial benzodiazepine agonist properties of Ro 15-1788 in pentylenetetrazol-induced seizures in cats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cats; Drug Interactions; Electroenceph | 1983 |
Evidence that the dorsal raphe area is involved in the effect of clonidine against pentylenetetrazole-induced seizures in rats.
Topics: 5,7-Dihydroxytryptamine; Animals; Anticonvulsants; Brain Chemistry; Brain Stem; Clonidine; Hydroxydo | 1984 |
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsatur | 1984 |
Effects of ascorbate on a dopaminergic response: apomorphine-induced modification of pentylenetetrazol-induced seizures in mice.
Topics: Animals; Apomorphine; Ascorbic Acid; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazol | 1984 |
Anticonvulsant and antipunishment effects of toluene.
Topics: Animals; Benzodiazepinones; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug | 1984 |
Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cyclooxygenase Inhibitors; Electroshock; Female; Hindlimb; Pe | 1984 |
Interruption of the mammillothalamic tract prevents seizures in guinea pigs.
Topics: Animals; Denervation; Efferent Pathways; Electroencephalography; Guinea Pigs; Lethal Dose 50; Mammil | 1984 |
Development of tolerance to the anticonvulsant effect of diazepam in dogs.
Topics: Animals; Anticonvulsants; Diazepam; Dogs; Drug Tolerance; Electrocardiography; Electroencephalograph | 1984 |
Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons).
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; Fem | 1984 |
Differential effects of picrotoxin- and pentylenetetrazol-induced convulsions on the secretion of luteinizing hormone and follicle-stimulating hormone in rats.
Topics: Animals; Calcium; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Male; Pentylenetetrazol | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Dr | 1984 |
[Mechanisms of local anesthetic-induced convulsions. The relation to brain catecholamines].
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; Dihydroxypheny | 1984 |
The electrocorticographic pattern of generalized seizures in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Dominance, Cerebral; Electroencephalography; Evoked Potentials; Mal | 1980 |
[Changes of the course of experimental epileptic attacks by curarization].
Topics: Animals; Cerebral Cortex; Electroencephalography; Male; Neuromuscular Nondepolarizing Agents; Paraox | 1980 |
[Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin].
Topics: Animals; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Valproic Acid | 1981 |
Effect of antiepileptic drugs on metrazol convulsions during ontogenesis in the rat.
Topics: Age Factors; Animals; Anticonvulsants; Clonazepam; Ethosuximide; Male; Pentylenetetrazole; Rats; Sei | 1981 |
Effect of chronic para-chlorophenylalanine treatment on convulsive-seizure reactions.
Topics: Amygdala; Animals; Brain; Electric Stimulation; Fenclonine; Kinetics; Male; Pentylenetetrazole; Rabb | 1981 |
[Effect of anticonvulsants on convulsions induced by kynurenine, quinolinic acid, strychnine and corazole].
Topics: Animals; Anticonvulsants; Kynurenine; Mice; Pentylenetetrazole; Quinolinic Acid; Quinolinic Acids; S | 1981 |
[Interaction of kynurenine and diazepam].
Topics: Animals; Benzoates; Caffeine; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; D | 1984 |
Anticonvulsant activity and neurotoxicity of piperonyl butoxide in mice.
Topics: Animals; Anticonvulsants; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Piperonyl Butoxide; | 1984 |
Adenosine deaminase in convulsions along with its regional, cellular and synaptosomal distribution in rat brain.
Topics: Adenosine Deaminase; Animals; Brain; Brain Stem; Cerebellum; Neuroglia; Neurons; Nucleoside Deaminas | 1984 |
Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the rat.
Topics: Animals; Drug Synergism; GABA Antagonists; Infusions, Parenteral; Injections, Intraperitoneal; Injec | 1984 |
Effect of convulsions induced by pentylenetetrazole or electricity on the dispositions of creatinine and urea in rats.
Topics: Animals; Creatinine; Electroshock; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; U | 1984 |
Kinetics of drug action in disease states III: Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats.
Topics: Electroshock; Female; Humans; Kinetics; Pentylenetetrazole; Phenytoin; Pregnancy; Pregnancy Complica | 1984 |
Hippocampal calcium-binding protein during commissural kindling-induced epileptogenesis: progressive decline and effects of anticonvulsants.
Topics: Animals; Calcium-Binding Proteins; Diazepam; Hippocampus; Kindling, Neurologic; Male; Pentylenetetra | 1984 |
The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil.
Topics: Animals; Disease Models, Animal; Electroshock; Endorphins; Epilepsy; Female; Gerbillinae; Male; Mode | 1984 |
Alteration of convulsive threshold and conditioned avoidance response in mice fed diets containing contraceptive steroids.
Topics: Animals; Avoidance Learning; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Diet; Female; Mes | 1984 |
Morphine responsiveness and seizure proneness.
Topics: Amygdala; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Electroshock; Kindling, Neuro | 1984 |
Metabolic and behavioral consequences of lidocaine-kindled seizures.
Topics: Aggression; Amygdala; Animals; Electroshock; Glucose; Humans; Lidocaine; Limbic System; Male; Pentyl | 1984 |
A spirohydantoin derivative of dimethoxytetrahydronaphthalene: an experimental anticonvulsant.
Topics: Animals; Anticonvulsants; Electroshock; Exploratory Behavior; Hydantoins; Male; Mice; Motor Activity | 1984 |
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pe | 1984 |
Spontaneous facial expressions occurring at onset of focal seizure activity.
Topics: Adolescent; Adult; Bemegride; Child; Child, Preschool; Electroencephalography; Emotions; Facial Expr | 1983 |
Synthesis of 3,4-dihydro-4-oxoquinazoline derivatives as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Magnetic Resonance Spectroscop | 1983 |
Synthesis of aminomethyl-substituted cyclic imide derivatives for evaluation as anticonvulsants.
Topics: Animals; Anticonvulsants; Biological Assay; Electroshock; Imidazoles; Indicators and Reagents; Injec | 1983 |
Generalized seizures alter the cerebral and peripheral metabolism of essential metals in mice.
Topics: Animals; Brain; Electroshock; Liver; Male; Metals; Mice; Mice, Inbred Strains; Pentylenetetrazole; S | 1983 |
Naloxone-6-spirohydantoin: a new non-toxic compound with anticonvulsive properties.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Hydantoins; Male; Mice; Nalox | 1983 |
Changes in [Ca2+]o and [K+]o during repetitive electrical stimulation and during pentetrazol induced seizure activity in the sensorimotor cortex of cats.
Topics: Animals; Calcium; Cats; Electric Stimulation; Motor Cortex; Pentylenetetrazole; Potassium; Seizures; | 1983 |
Induction of semichronic epileptic foci using cobalt oxide.
Topics: Animals; Cats; Cerebral Cortex; Cobalt; Pentylenetetrazole; Seizures | 1983 |
Surgical control of semichronic epileptic foci in the cat's sensorimotor cortex.
Topics: Animals; Cats; Cobalt; Electroencephalography; Pentylenetetrazole; Seizures; Somatosensory Cortex | 1983 |
Local PO2 and unit activity measured with an oxygen microelectrode from the gerbil cerebral cortex during seizure and EEG suppression.
Topics: Animals; Barbiturates; Brain; Electroencephalography; Gerbillinae; Male; Microelectrodes; Oxygen; Ox | 1983 |
Effect of morphine pretreatment on pentylenetetrazol-induced seizures in the rat.
Topics: Animals; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Male; Morphine; Motor | 1983 |
Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam.
Topics: Animals; Diazepam; Drug Tolerance; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Myoclonus; Pentylen | 1983 |
Behavioral comparison of pentylenetetrazol, clonidine, chlordiazepoxide and diazepam in infant rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Chlordiazepoxide; Clonidine; Diazepam; Mot | 1983 |
Differential rearing affects responsiveness of rats to depressant and convulsant drugs.
Topics: Animals; Arousal; Dose-Response Relationship, Drug; Female; Male; Muridae; Pentobarbital; Pentylenet | 1983 |
Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Ethosuximide; Male; Pentylenetetrazole; Rats; Rats | 1983 |
Anticonvulsant activity of milacemide.
Topics: Acetamides; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; gamma-Aminobutyri | 1983 |
An EEG investigation on the effects of phencyclidine on pentylentetrazol convulsions in rats and rabbits.
Topics: Animals; Electroencephalography; Male; Pentylenetetrazole; Phencyclidine; Phenobarbital; Rabbits; Ra | 1983 |
Increased susceptibility to pentylenetetrazol-induced seizures in adult rats following electrical kindling during brain development.
Topics: Animals; Brain; Electroshock; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Inbred Str | 1983 |
Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice.
Topics: Animals; Bicuculline; Brain; Brain Chemistry; Electroshock; Female; Malonates; Mice; Mice, Inbred St | 1983 |
Primidone, phenobarbital, and PEMA: II. Seizure protection, neurotoxicity, and therapeutic index of varying combinations in mice.
Topics: Animals; Brain; Brain Chemistry; Drug Synergism; Drug Therapy, Combination; Electroshock; Female; Ma | 1983 |
Effects of central monoamine compounds on tranylcypromine-induced barbital-withdrawal convulsions.
Topics: alpha-Methyltyrosine; Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Humans; Mal | 1983 |
Inhibition of pentylenetetrazol induced genetically-determined stereotypic convulsions in tottering mutant mice by diazepam.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Mi | 1983 |
Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile.
Topics: Animals; Anticonvulsants; Electroencephalography; Electroshock; Female; Imidazoles; Male; Mice; Moto | 1983 |
Metabolic, circulatory, and structural alterations in the rat brain induced by sustained pentylenetetrazole seizures.
Topics: Animals; Brain; Cerebrovascular Circulation; Fatty Acids, Nonesterified; Glycolysis; Male; Nucleotid | 1984 |
Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; M | 1984 |
Correlation between electrocorticographic and motor phenomena induced by pentamethylenetetrazol during ontogenesis in rats.
Topics: Animals; Brain; Electroencephalography; Myoclonus; Pentylenetetrazole; Rats; Rats, Inbred Strains; S | 1984 |
Substituted (omega-aminoalkoxy) stilbene derivatives as a new class of anticonvulsants.
Topics: Animals; Anticonvulsants; Biological Assay; Drug Evaluation, Preclinical; Electroshock; Indicators a | 1984 |
Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds.
Topics: Animals; Bicuculline; Injections, Intraventricular; Isomerism; Kynurenine; Male; Pentylenetetrazole; | 1984 |
Neuropharmacology of delta-aminolaevulinic acid--I. Effect of acute administration in rodents.
Topics: Aminolevulinic Acid; Analgesia; Animals; Blood Pressure; Heart Rate; Levulinic Acids; Mice; Motor Ac | 1984 |
Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs.
Topics: Animals; Dog Diseases; Dogs; Female; Humans; Male; Muscle Contraction; Muscle Tonus; Pentylenetetraz | 1984 |
Behavioral studies with mice exposed to DC and 60-Hz magnetic fields.
Topics: Animals; Anisomycin; Avoidance Learning; Behavior, Animal; Electromagnetic Fields; Electromagnetic P | 1984 |
Anticonvulsant activity of some 4-aminobenzamides.
Topics: Animals; Anticonvulsants; Benzamides; Bicuculline; Electroshock; Male; Mice; Pentylenetetrazole; Sei | 1984 |
Comparative study of the anticonvulsive activity of N-aminomethylpiperazine-3,3-diethyl 2,4-pyridinedione with the activity of known antiepileptic agents.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Lethal Dose 50; Male; Mice; Mice, Inbred Str | 1984 |
Development and persistence of kindled seizures after repeated injections of pentylenetetrazol in rats and guinea pigs.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Injections, Intraperitoneal; Kindling, Neuro | 1984 |
Production of convulsions in mice by the combination of methionine and homocysteine.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Ethionine; Female; Homo | 1980 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; | 1981 |
Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice.
Topics: Animals; Drug Administration Schedule; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Seizures; V | 1981 |
Convulsant-specific architecture of the postictal behavior syndrome in the rat.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Catatonia; Convulsants; Disease Models, Animal; Electr | 1981 |
Change in sensitivity to insulin hypoglycemic convulsions after gold thioglucose treatment: time course of development.
Topics: Animals; Aurothioglucose; Body Weight; Brain; Female; Gold; Gold Sodium Thiomalate; Hypoglycemia; In | 1981 |
Regional distribution of arachidonic acid metabolites in rat brain following convulsive stimuli.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Electroshock; Female; Indomethacin; Pentylenete | 1981 |
Comparison of insulin hypoglycemia-induced and fluoroacetate-induced convulsions in gold thioglucose lesioned mice.
Topics: Animals; Aurothioglucose; Blood Glucose; Body Weight; Citrates; Citric Acid; Female; Fluoroacetates; | 1981 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; | 1982 |
Effects of apomorphine and piribedil on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Apomorphine; Drug Interactions; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Piperazines | 1981 |
The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat.
Topics: Administration, Oral; Amygdala; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electro | 1982 |
Specific action of tranylcypromine to precipitate barbital withdrawal convulsions.
Topics: Animals; Barbital; Barbiturates; Humans; Monoamine Oxidase Inhibitors; Pentylenetetrazole; Rats; Rat | 1982 |
Effect of disulfiram in combination with L-tryptophan and lithium on pentylenetetrazol-induced seizure.
Topics: Animals; Disulfiram; Drug Therapy, Combination; Lithium; Male; Mice; Mice, Inbred ICR; Pentylenetetr | 1982 |
Effects of bipiperidyl mustard (BPM) lesions on insulin hypoglycemic convulsions.
Topics: Animals; Aurothioglucose; Body Weight; Eating; Female; Hypoglycemia; Insulin; Mice; Mice, Inbred CBA | 1982 |
Electroshock raises pentylenetetrazol threshold: possible role of inosine.
Topics: Animals; Electroshock; Hypoxanthines; Inosine; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; | 1983 |
Effects of seizures on ion transport and membrane protein phosphorylation.
Topics: Animals; Brain; Calcium; Electroshock; Membrane Proteins; Nerve Tissue Proteins; Pentylenetetrazole; | 1983 |
[Formation of generalized convulsive activity in mice administered corazol daily in subthreshold doses].
Topics: Animals; Dose-Response Relationship, Drug; Kindling, Neurologic; Mice; Mice, Inbred BALB C; Mice, In | 1983 |
Cardiac neural discharge and epileptogenic activity in the cat: an animal model for unexplained death.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Death, Sudden; Electr | 1983 |
The effects of doxapram, diazepam, phenobarbital and pentylenetetrazol on suprathreshold and threshold stimulations in amygdaloid kindled rats.
Topics: Amygdala; Animals; Diazepam; Doxapram; Kindling, Neurologic; Male; Pentylenetetrazole; Phenobarbital | 1983 |
Serotonin mediation of the protective effect of clonidine against pentylenetetrazol-induced seizures in rats.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Fenfluramine; Male; Metergoline; Methysergide; | 1983 |
Effects of carbamazepine and diphenylhydantoin on metrazol seizures during ontogenesis in rats.
Topics: Aging; Animals; Carbamazepine; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Inbred Strains; Seiz | 1983 |
Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Body Temperature; Female; GABA Antagonists; gamma-Am | 1983 |
Brain content of immunoreactive [Leu5]enkephalin and [Met5]enkephalin after pentylenetetrazol-induced convulsions.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Male; Pentylenetetrazole; Radioimmunoas | 1983 |
Pentylenetetrazol seizures in mice: effect on brain inosine and hypoxanthine.
Topics: Animals; Hypoxanthines; Inosine; Male; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Seizures | 1983 |
Increase in brain prostaglandins during convulsions is due to increased neuronal activity and not to hypoxia.
Topics: Animals; Brain Chemistry; Hypoxia, Brain; Male; Mice; Muscle Relaxation; Neurons; Pancuronium; Penty | 1983 |
Topical perfusion of metrazol in the central nervous system of "encephale isole" cats.
Topics: Animals; Brain; Cats; Decerebrate State; Electroencephalography; Electromyography; Pentylenetetrazol | 1983 |
[Comparison of the anticonvulsant and central effects of 3-bromophenylsuccinimide and N-methylimide of 3,5-dibromophenylsuccinic acid].
Topics: Animals; Anticonvulsants; Bicuculline; Bromosuccinimide; Depression, Chemical; Female; Humans; Hypno | 1982 |
Induction of pentylenetetrazol convulsions by polysaccharide--protein complex isolated from Candida albicans.
Topics: Animals; Candida albicans; Carbon Tetrachloride; Cell Wall; Convulsants; Endotoxins; Glycoproteins; | 1980 |
The influence in rabbits and rats of gamma-acetylenic GABA on seizures generated by pentylenetetrazol.
Topics: Alkynes; Aminocaproates; Animals; Electroencephalography; Pentylenetetrazole; Rabbits; Rats; Rats, I | 1980 |
[Preliminary pharmacological studies on 6 new derivatives of 5-phenylimidazoline].
Topics: Animals; Convulsants; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Imidazoles; Mice; Mice, | 1981 |
Pharmacological investigation of convulsant gamma-aminobutyric acid (GABA) antagonists in amygdala-kindled rats.
Topics: Amygdala; Animals; Convulsants; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Kindling, | 1982 |
Experimental febrile convulsions: long-term effects of hyperthermia-induced convulsions in the developing rat.
Topics: Age Factors; Animals; Body Temperature; Growth; Hot Temperature; Myoclonus; Pentylenetetrazole; Rats | 1982 |
Effect of eboracin on convulsive seizures in mice: enhancement of myoclonus and inhibition of the tonic phase.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Electroshock; Indenes; Male; Mice; Myoclonus; Pentyl | 1982 |
Role of nasal air flow in convulsions induced by lidocaine in the rat.
Topics: Animals; Electrodes, Implanted; Lidocaine; Male; Olfactory Bulb; Pentylenetetrazole; Pulmonary Venti | 1982 |
The effect of anticonvulsant drugs on convulsions triggered by direct stimulation of the brainstem.
Topics: Animals; Anticonvulsants; Brain Stem; Dose-Response Relationship, Drug; Electric Stimulation; Evoked | 1982 |
Influence of clonazepam and ethosuximide on ECoG pattern induced by metrazol during ontogenesis in rats.
Topics: Age Factors; Animals; Benzodiazepinones; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Dr | 1982 |
Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability.
Topics: Animals; Dogs; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Seizures; Seizur | 1982 |
Anti-metrazol effects of nitrazepam during ontogenesis in the rat.
Topics: Age Factors; Animals; Animals, Newborn; Male; Nitrazepam; Pentylenetetrazole; Rats; Rats, Inbred Str | 1982 |
[Dispersion analysis used for assessing the anticonvulsant activity of 1,4-benzodiazepines].
Topics: Analysis of Variance; Animals; Anticonvulsants; Benzodiazepines; Convulsants; Drug Evaluation, Precl | 1982 |
Pentylenetetrazole induced changes in cerebellar energy metabolism.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Cerebellum; Energy Metabolism; gam | 1982 |
Post-ictal locomotor activity in three different rat models of epilepsy.
Topics: Amygdala; Animals; Disease Models, Animal; Electroshock; Kindling, Neurologic; Male; Motor Activity; | 1982 |
Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.
Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Pent | 1982 |
Effect of trimethyltin on chemically-induced seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Isoniazid; Male; Mice; Pentylenetetrazole; Seizures; Strychni | 1982 |
Effect of glutamate dimethyl ester and glutamate diethyl ester in delaying the onset of convulsions induced by pentylenetetrazol and strychnine.
Topics: Animals; Excitatory Amino Acid Antagonists; Female; Glutamates; Pentylenetetrazole; Rats; Rats, Inbr | 1982 |
Hypophyseal hormone levels in blood and cerebrospinal fluid in response to histamine and pentylenetetrazol.
Topics: Animals; Arginine Vasopressin; Histamine; Kinetics; Male; Melanocyte-Stimulating Hormones; Oxytocin; | 1982 |
Bidirectional transfer of intracerebrally administered pentylenetetrazol and electrical kindling.
Topics: Amygdala; Animals; Dominance, Cerebral; Dose-Response Relationship, Drug; Kindling, Neurologic; Male | 1982 |
Reactivity of the central nervous system in the disseminated intravascular coagulation in rats.
Topics: Animals; Biogenic Amines; Brain; Brain Chemistry; Disseminated Intravascular Coagulation; Fibrinogen | 1982 |
[Effect of new pyrazolo-(1,2-a)-1,2,5-triazepine derivatives on the central nervous system].
Topics: Animals; Anticonvulsants; Azepines; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Mice; Mic | 1982 |
Changes in the convulsive threshold in the developing rat following chronic administration of pentylenetetrazol.
Topics: Age Factors; Animals; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1982 |
Autonomic dysfunction in epilepsy: characterization of autonomic cardiac neural discharge associated with pentylenetetrazol-induced epileptogenic activity.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Cats; Heart; Parasympathetic Nervo | 1982 |
Ketamine suppression of chemically induced convulsions in the two-day-old white leghorn cockerel.
Topics: Animals; Anticonvulsants; Brain; Chickens; Dose-Response Relationship, Drug; Ketamine; Models, Neuro | 1980 |
[Drug distribution during convulsive seizure in comparison with narcosis].
Topics: Adipose Tissue; Animals; Antipyrine; Brain; Female; Liver; Pentylenetetrazole; Phenobarbital; Rats; | 1980 |
Behavioural correlates of an experimental hippocampal epileptiform syndrome in rats.
Topics: Aggression; Animals; Behavior, Animal; Evoked Potentials; Exploratory Behavior; Hippocampus; Humans; | 1981 |
Alteration of convulsive threshold and sensitivity to CNS acting drugs in sedative-hypnotics-experienced rat offspring.
Topics: Animals; Animals, Newborn; Animals, Suckling; Ethanol; Female; Humans; Hypnotics and Sedatives; Moto | 1982 |
Eboracin: a substituted indenopyrrole active against metrazol-induced, audiogenic and electroshock seizures in mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Inde | 1982 |
Lowering of the convulsive threshold by non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Brain; Male; Mice; Pentylenetetrazole; Prostaglandins E; Prostagl | 1981 |
Differential antagonisms of anticonvulsants to various components of maximal seizures induced by electroshock or pentylenetetrazol in mice.
Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Seizures; Time Factors | 1980 |
[Nature of the relation between the anticonvulsant action of phenazepam and its concentration in mouse brain].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain Chemistry; | 1981 |
The anticonvulsant properties of melatonin on kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Melatonin; Naloxone; Penty | 1981 |
Studies on prostaglandin F2 alpha formation caused by pentametylenetetrazol-induced convulsions in rat brain.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Hypoxia, Brain; Male; Pentylenetetrazole; Prostagl | 1981 |
Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia.
Topics: Anesthesia; Animals; Brain Diseases; Cats; Enflurane; Female; Lidocaine; Male; Pentylenetetrazole; S | 1981 |
Electrocorticographic activity elicited by metrazol during ontogenesis in rats.
Topics: Aging; Animals; Electroencephalography; Male; Pentylenetetrazole; Rats; Seizures | 1980 |
Seizures elicited by subcutaneous injection of metrazol during ontogenesis in rats.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Rats; Reaction Tim | 1980 |
Effects of PTZ-induced generalized epilepsy on intestinal activity in cats.
Topics: Adrenalectomy; Animals; Cats; Electroencephalography; Electromyography; Intestine, Small; Male; Pent | 1981 |
Baclofen as an anticonvulsant in experimental models of convulsions.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Baclofen; Disease Models, Animal; Dose-Resp | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Pentylenetetrazole; Phenob | 1981 |
On some relationships between GABA-ergic and 5-HT-ergic mechanisms in pentylenetetrazol convulsive-seizure reactions.
Topics: Animals; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Seizures; Serotonin | 1980 |
Drug interactions between centazolone & some centrally acting agents.
Topics: Amphetamine; Animals; Drug Interactions; Pentylenetetrazole; Quinazolines; Rats; Seizures; Strychnin | 1981 |
Diphenylhydantoin potentiates the protective effect of diazepam against pentylenetetrazol but not against bicuculline and isoniazid-induced seizures in mice.
Topics: Animals; Bicuculline; Diazepam; Drug Synergism; Isoniazid; Male; Mice; Pentylenetetrazole; Phenytoin | 1981 |
Increased nucleotide catabolism after cerebral convulsions.
Topics: Animals; Child; Epilepsy; Female; Humans; Hypoxanthines; Nucleotides; Pentylenetetrazole; Rabbits; S | 1981 |
The effects of various anesthetics on amygdaloid kindled seizures.
Topics: 4-Butyrolactone; Amygdala; Anesthetics; Animals; Central Nervous System; Electroencephalography; Hyd | 1981 |
Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy.
Topics: Animals; Bicuculline; Brain; Deoxy Sugars; Deoxyglucose; Electric Conductivity; Glucose; Kainic Acid | 1981 |
Carbohydrate metabolism in extraneural tissues in leptazol-induced convulsions & on gamma-aminobutyric acid pretreatment.
Topics: Animals; Carbohydrate Metabolism; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Seizures | 1981 |
Effect of diazepam alone and in combination with chlorpromazine or propranolol in experimentally induced convulsions in mice.
Topics: Animals; Chlorpromazine; Diazepam; Drug Therapy, Combination; Electroshock; Male; Mice; Pentylenetet | 1981 |
Muscimol and gamma-hydroxybutyrate: similar interactions with convulsant agents.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; D | 1981 |
Reduced and oxidized glutathione in brain and convulsions.
Topics: Animals; Brain; Electroshock; Glutathione; Glutathione Disulfide; Mice; Oxidation-Reduction; Pentyle | 1981 |
Antagonism of experimentally induced tonic seizures following a lesion in the midbrain tegmentum.
Topics: Animals; Disease Models, Animal; Electroshock; Flurothyl; Hindlimb; Male; Muscles; Pentylenetetrazol | 1981 |
Specific and nonspecific multiple-unit activities during pentylenetetrazol seizures in animals with pretrigeminal brain stem transection.
Topics: Animals; Brain Stem; Cats; Decerebrate State; Electroencephalography; Male; Neurons; Pentylenetetraz | 1981 |
Post-ictal resistance to audiogenic seizures in inbred mice.
Topics: Acoustic Stimulation; Animals; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Refractory Peri | 1980 |
Pharmacologic analysis of the postictal immobility syndrome in the rat.
Topics: Animals; Behavior, Animal; Electroencephalography; Electroshock; Epilepsy; Female; Haloperidol; Moto | 1981 |
Vasotocin protects rats against convulsions induced by pentylenetetrazol.
Topics: Animals; Kinetics; Male; Pentylenetetrazole; Rats; Seizures; Vasotocin | 1981 |
Relationship between drug-induced changes in seizure thresholds and the GABA content of brain and brain nerve endings.
Topics: Animals; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Nerve Endings; Pentylen | 1981 |
Facilitation of kindling by convulsions induced by cocaine or lidocaine but not pentylenetetrazol.
Topics: Animals; Behavior, Animal; Cocaine; Electric Stimulation; Kindling, Neurologic; Lidocaine; Male; Olf | 1981 |
Anticonvulsant properties of two new 3,3-diethyl-2,4-pyridinedione derivatives. I. Effects in two experimental models of generalized epilepsy in cats.
Topics: Animals; Anticonvulsants; Brain; Cats; Disease Models, Animal; Pentylenetetrazole; Pyridones; Seizur | 1981 |
[Phenytoin and ethyl alcohol interactions in rats with regard to their effect on the central nervous system after single dose administration].
Topics: Animals; Drug Interactions; Ethanol; Male; Pentylenetetrazole; Phenytoin; Rats; Seizures | 1981 |
Mechanism of respiratory stimulant action of 4-(4-morpholinyl)-2,3-pentamethylenequinoline (compound 65/127) in cat.
Topics: Animals; Cats; Decerebrate State; Pentylenetetrazole; Quinolines; Respiration; Seizures | 1981 |
Incorporation of N-acetylmannosamine into rat brain subcellular gangliosides: effect of pentylenetetrazol-induced convulsions on brain gangliosides.
Topics: Animals; Brain; Carbon Radioisotopes; Gangliosides; Hexosamines; Isotope Labeling; Mannose; Microsom | 1980 |
Enhancement of mesencephalic reticular neuronal responses to sensory stimuli with pentylenetetrazol.
Topics: Acoustic Stimulation; Animals; Cats; Electric Stimulation; Mesencephalon; Neurons; Pentylenetetrazol | 1980 |
Cetyl GABA: effect on convulsant thresholds in mice and acute toxicity.
Topics: Animals; Brain Chemistry; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; S | 1980 |
Redox transitions in mitochondria of cat cerebral cortex with seizures and hemorrhagic hypotension.
Topics: Animals; Cats; Cerebral Cortex; Cytochromes; Hemorrhage; Hypotension; Mitochondria; NAD; Oxidation-R | 1980 |
Anticonvulsant activity of cyclopentano amino acids.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Anticonvulsants; Cycloleucine; Dose-Response Relationsh | 1980 |
Anticonvulsant properties of selected pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates.
Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenytoin; Pyrimidinones; Py | 1980 |
Effects of kindling or brain stimulation on pentylenetetrazol-induced convulsion susceptibility.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Male; Pentylenetetrazole; Ra | 1980 |
Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bemegride; Bicuculline; Drug Interactions; Excit | 1980 |
Amygdala kindling induces muscarinic cholinergic receptor declines in a highly specific distribution within the limbic system.
Topics: Amygdala; Animals; Electric Stimulation; Kinetics; Limbic System; Male; Pentylenetetrazole; Quinucli | 1980 |
Regional brain ascorbic acid distribution: its functional relationship to appetite and leptazol-induced convulsions in guinea-pigs.
Topics: Animals; Appetite Regulation; Ascorbic Acid; Ascorbic Acid Deficiency; Brain; Dose-Response Relation | 1980 |
Cerebral microvessel 2-deoxy-D-glucose uptake during ischemia-induced seizures.
Topics: Animals; Brain; Brain Ischemia; Deoxy Sugars; Deoxyglucose; Female; Gerbillinae; Male; Microcirculat | 1980 |
Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Subcutane | 1980 |
6-Hydroxydopamine and Metrazol seizures in mice: inhibition of the tonic-clonic phase.
Topics: Animals; Drug Interactions; Hydroxydopamines; Mice; Myoclonus; Pentylenetetrazole; Seizures | 1980 |
[Effect of phenobarbital on metrazol convulsions during ontogenesis of rats (author's transl)].
Topics: Age Factors; Animals; Male; Pentylenetetrazole; Phenobarbital; Rats; Seizures | 1980 |
Spontaneous generalized spike-wave discharges in the electrocorticograms of albino rats.
Topics: Animals; Cerebral Cortex; Electroencephalography; Evoked Potentials; Male; Pentylenetetrazole; Rats; | 1980 |
On the measurement in rats of the convulsant effect of drugs and the changes which follow electroconvulsive shock.
Topics: Animals; Bicuculline; Convulsants; Electroshock; Infusions, Parenteral; Injections, Intraperitoneal; | 1980 |
Developmental, behavioral, and pharmacological characteristics of rat offspring from mothers receiving ethanol during gestation or lactation.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Body Weight; Female; Lactation; Male; Maternal Behavior | 1980 |
Paleocerebellar influence upon avian cerebral excitability.
Topics: Animals; Brain; Cerebellum; Chickens; Female; Male; Pentylenetetrazole; Seizures | 1980 |
The incidence of electroshock and pentylenetetrazole (Metrazol) induced convulsions in hypoglycaemic and acute and chronic hyperglycaemic states in mice.
Topics: Animals; Electroshock; Hyperglycemia; Hypoglycemia; Male; Maximum Allowable Concentration; Mice; Pen | 1980 |
[Phenothiazine carboxamides that have anticholinergic properties].
Topics: Animals; Behavior, Animal; Convulsants; Dogs; Mice; Nicotine; Parasympatholytics; Pentylenetetrazole | 1980 |
Biochemical evidence of decreased muscarinic cholinergic neuronal communication following amygdala-kindled seizures.
Topics: Acetylcholinesterase; Amygdala; Animals; Biological Transport, Active; Choline; Male; Neurons; Penty | 1981 |
Seizure related changes in the regulation of opioid genes and transcription factors in the dentate gyrus of rat hippocampus.
Topics: Animals; Behavior, Animal; Dentate Gyrus; DNA; Enkephalins; Gene Expression Regulation; Genes, fos; | 1995 |
Pentylenetetrazol causes polysynaptic responses to appear in the dentate gyrus.
Topics: Animals; Convulsants; Dentate Gyrus; Electric Stimulation; Evoked Potentials; Male; Pentylenetetrazo | 1995 |
Synthesis and pharmacological evaluation of spiro-analogues of 5-benzyl-5-ethyl barbituric acid.
Topics: Animals; Anticonvulsants; Barbiturates; Electroshock; Mice; Pentylenetetrazole; Rats; Rats, Sprague- | 1995 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; D | 1993 |
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bicuculline; Cerebrovascular Circulation; Enzyme Inhi | 1994 |
Opioid peptides content in the rat brain during the ictal phase and after pentylenetetrazol-kindled rats.
Topics: Animals; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Kindling, Neurologic; Male; | 1995 |
Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide and prototype antiepileptic drugs in mice and rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamazepine; Drug Evaluation, Preclinical | 1995 |
Ethnopharmacology of bear gall bladder: I.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Bile; Bile Ac | 1995 |
[Mice selected on the basis of low weight are more selective to the convulsant effect of pentylenetetrazole].
Topics: Animals; Body Weight; Convulsants; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures | 1995 |
Pentylenetetrazol-induced kindling in animals: protective effect of BR-16A.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Female; Kindling, Neurologic; Male; Mice; Mice, Inb | 1995 |
Prenatal cocaine: seizure susceptibility in rat offspring.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Body Weight; Brain; Cocaine; Female; Humans; In | 1995 |
Comparative behavioral characterization of the neuroactive steroids 3 alpha-OH,5 alpha-pregnan-20-one and 3 alpha-OH,5 beta-pregnan-20-one in rodents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Dose-Response Relationship, | 1995 |
Anticonvulsant activity of phenytoin-lipid conjugates, a new class of phenytoin prodrugs.
Topics: Administration, Oral; Animals; Anticonvulsants; Dimethyl Sulfoxide; Electroshock; Hydrolysis; In Vit | 1995 |
Moderate hypoxia reduces pentylenetetrazol-induced seizures.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agents; Hypoxia; Male; Mice; Mice, Inbred Strain | 1995 |
Functional effects of D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2 and differential changes in somatostatin receptor messenger RNAs, binding sites and somatostatin release in kainic acid-treated rats.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding Sites; Hippocampus; In Situ Hybri | 1995 |
Kainate/AMPA receptor antagonists are anticonvulsant against the tonic hindlimb component of pentylenetetrazol-induced seizures in developing rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Anticonvulsants; Behavior, Animal; Epilepsy, T | 1995 |
Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Injections, Su | 1995 |
Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Elec | 1995 |
Synthesis and biological activities of some 3,6-disubstituted thiazolo[3,2-b][1,2,4]triazoles.
Topics: Animals; Anticonvulsants; Antifungal Agents; Candida; Electroshock; Male; Mice; Microbial Sensitivit | 1995 |
Neonatal caffeine exposure and seizure susceptibility in adult rats.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazo | 1995 |
Distribution of unsaturated metabolites of valproate in human and rat brain--pharmacologic relevance?
Topics: Adolescent; Adult; Aged; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Chemistry; | 1995 |
Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats.
Topics: Animals; Delayed-Action Preparations; Epilepsy, Generalized; Female; Infusions, Intravenous; Pentyle | 1995 |
Pharmacodynamic interactions of cypermethrin and centrally acting drugs in mice.
Topics: Acepromazine; Amphetamine; Animals; Central Nervous System Agents; Dipyrone; Drug Interactions; Inse | 1995 |
Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Topics: Animals; Brain Chemistry; Chlorides; Chlorine; Female; gamma-Aminobutyric Acid; Lorazepam; Mice; Mus | 1995 |
Chemical and pharmacological properties of new tetrahydropyrimido-[2,1-f]-purines.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Body Temperature; | 1995 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Age | 1993 |
The effect of profound hypothermia on blood-brain barrier permeability during pentylenetetrazol-induced seizures.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain; Hypothermia, Induced; Male; Pentylenetetrazole; | 1994 |
Synthesis and preliminary pharmacological assessment of derivatives of isoxazolo[4,3-d]pyrimidine. II.
Topics: Animals; Behavior, Animal; Drug Design; Electroshock; Lethal Dose 50; Male; Mice; Pentylenetetrazole | 1994 |
The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Ra | 1995 |
Effect of fetal hypoxia on seizure susceptibility in rats.
Topics: Animals; Electrocardiography; Female; Fetal Hypoxia; Male; Pentylenetetrazole; Pregnancy; Prenatal E | 1995 |
Effects of repeated injection of cyclosporin A on pentylenetetrazol-induced convulsion and cyclophilin mRNA levels in rat brain.
Topics: Amino Acid Isomerases; Animals; Base Sequence; Brain; Carrier Proteins; Cyclosporine; Drug Administr | 1995 |
Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug In | 1995 |
An animal model for the study of neurotoxicity of bacterial products and application of the model to demonstrate that Shiga toxin and lipopolysaccharide cooperate in inducing neurologic disorders.
Topics: Animals; Bacterial Toxins; Disease Models, Animal; Escherichia coli; Lipopolysaccharides; Male; Mice | 1995 |
Synthesis and anticonvulsant activity of some new 1,1-bis(4-substituted 1,2,4-triazoline-5-thione-3-yl)-2-methylbutanes.
Topics: Animals; Anticonvulsants; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Pentylenet | 1995 |
Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem.
Topics: Analysis of Variance; Animals; Binding, Competitive; Cilastatin; Dose-Response Relationship, Drug; g | 1995 |
The effects of adenosine A3 receptor stimulation on seizures in mice.
Topics: Adenosine; Animals; Clonidine; Drug Interactions; Electroshock; Injections, Intraperitoneal; Male; M | 1995 |
Ontogenetic development and pentylenetetrazol seizure thresholds in rats.
Topics: Aging; Animals; Behavior, Animal; Epilepsy, Tonic-Clonic; Female; Male; Pentylenetetrazole; Rats; Ra | 1995 |
Pentylenetetrazole-induced seizure up-regulates levels of microtubule-associated protein 1B mRNA and protein in the hippocampus of the rat.
Topics: Animals; Blotting, Northern; Female; Hippocampus; Humans; Immunoblotting; Microtubule-Associated Pro | 1995 |
Effects of repeated immunosuppressant treatment on rat pentylenetetrazol-induced convulsion.
Topics: Animals; Autoimmune Diseases; Cyclosporine; Electroencephalography; Injections, Intraperitoneal; Mal | 1994 |
Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Pentylenetetrazole; Phencyclidine; Rats; Rats, Sp | 1994 |
Evidence for central benzodiazepine receptor heterogeneity from behavior tests.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Body Temperature; Central Nervous System; Dose- | 1994 |
Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats.
Topics: Animals; Antibodies; Chronic Disease; Disease Susceptibility; Dose-Response Relationship, Drug; Elec | 1994 |
The effect of corticosterone in rats submitted to the elevated plus-maze and to to pentylenetetrazol-induced convulsions.
Topics: Administration, Cutaneous; Animals; Anti-Anxiety Agents; Corticosterone; Dose-Response Relationship, | 1994 |
Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam.
Topics: Alprazolam; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Down-Regulation; Drug Tolera | 1993 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug | 1993 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flu | 1993 |
Conditional attenuation of the antipentylenetetrazol activity of chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Chlordiazepoxide; Chlorpromazine; Conditioning, Operant; | 1993 |
Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats.
Topics: Animals; Cerebral Cortex; Differential Threshold; Electroencephalography; Electronic Data Processing | 1994 |
Chronic pharmacological activities of the novel anxiolytic beta-carboline abecarnil in rats.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Drinking Behavior; Male; Memory; Pentylenetetraz | 1994 |
Essential fatty acid preparation (SR-3) raises the seizure threshold in rats.
Topics: Acoustic Stimulation; alpha-Linolenic Acid; Animals; Anticonvulsants; Electroshock; Fatty Acids, Ess | 1994 |
2-Thiazolylethylamine, a selective histamine H1 agonist, decreases seizure susceptibility in mice.
Topics: Animals; Anticonvulsants; Dimaprit; Dose-Response Relationship, Drug; Electroshock; Histamine; Hista | 1994 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose | 1994 |
Anticonvulsant activity of some 4-amino-N-phenylphthalimides and N-(3-amino-2-methylphenyl)phthalimides.
Topics: Animals; Anticonvulsants; Electroshock; Guinea Pigs; Male; Mice; Mice, Inbred Strains; Pentylenetetr | 1994 |
Comparison of anticonvulsant tolerance, crosstolerance, and benzodiazepine receptor binding following chronic treatment with diazepam or midazolam.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain; Diazepam; Drug Tolerance | 1994 |
Persistent physiological effects caused by a single pentylenetetrazol induced seizure in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Electrodes, Implanted; Evoked Potentials; Hippocampus; In Vitro Te | 1994 |
Stereoselective pharmacokinetics of stiripentol: an explanation for the development of tolerance to anticonvulsant effect.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Dioxolanes; Drug Tolerance; H | 1994 |
Activation of the c-fos gene in prodynorphin- and proenkephalin-expressing cells of nucleus tractus solitarius after seizures.
Topics: Animals; Enkephalins; Gene Expression Regulation; Genes, fos; In Situ Hybridization; Medulla Oblonga | 1994 |
The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid.
Topics: Animals; Anticonvulsants; Estrus; Female; Male; Pentylenetetrazole; Pregnanolone; Rats; Rats, Spragu | 1994 |
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Bemegride; Calcium Channel Blockers; Dihydropyridine | 1994 |
Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Histamine Agonists; Histamine Antagonists; | 1994 |
New 4-arylaminopiperidines with antihypoxic and anticonvulsive activity.
Topics: Animals; Anticonvulsants; Cell Survival; Cyanides; Hypoxia; Male; Mice; Mice, Inbred Strains; Pentyl | 1994 |
Naloxone ameliorates the learning deficit induced by pentylenetetrazol kindling in rats.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Kindling, Neurologic; Learning Disabi | 1994 |
AP-1 and CRE DNA binding activities in rat brain following pentylenetetrazole induced seizures.
Topics: Activating Transcription Factor 2; Animals; Base Sequence; Binding Sites; Binding, Competitive; Brai | 1994 |
Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Evaluation, Preclinical; Electroshock; Hippocampus; In | 1994 |
Nuclear factor-kappa B in rat brain: enhanced DNA-binding activity following convulsant-induced seizures.
Topics: Animals; Autoradiography; Base Sequence; Blotting, Western; Brain Chemistry; Convulsants; DNA; Elect | 1994 |
Structure-activity relationships in thienodiazepine and benzodiazepine derivatives.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Azepines; Benzodiazepines; Benz | 1994 |
[Alimentary modification of catecholamine levels and status of the thiol-dependent protective system in the brain in convulsive syndrome].
Topics: Animals; Brain; Catecholamines; Chronic Disease; Diet; Glutathione Peroxidase; Glutathione Transfera | 1993 |
Effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Endothelins; gamma-Aminobutyric Acid; Injections, Intraventri | 1994 |
Anticonvulsant properties of copper acetazolamide complexes.
Topics: Acetazolamide; Animals; Anticonvulsants; Copper; Electroshock; Male; Mice; Organometallic Compounds; | 1994 |
Seizures-evoked activation of transcription factors.
Topics: Animals; Brain; DNA; Kainic Acid; Pentylenetetrazole; Protein Binding; Proto-Oncogene Proteins c-jun | 1994 |
Is the site of action of ethosuximide in the hindbrain?
Topics: Animals; Anticonvulsants; Brain Stem; Clonazepam; Decerebrate State; Electrocardiography; Electroenc | 1994 |
gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Clonidine; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizu | 1994 |
Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression.
Topics: Anesthesia; Animals; Histiocytoma, Benign Fibrous; Male; Paraplegia; Pentylenetetrazole; Phenobarbit | 1994 |
Synthesis and evaluation of amino analogues of valproic acid.
Topics: Animals; Anticonvulsants; Electroshock; Injections, Intraperitoneal; Mice; Pentylenetetrazole; Seizu | 1994 |
The effect of immunosuppression by total-body irradiation on the pharmacodynamics of centrally active drugs in rats.
Topics: Animals; Brain; Central Nervous System Agents; Central Nervous System Depressants; Ethanol; Female; | 1994 |
Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice.
Topics: Animals; Corticosterone; Disease Susceptibility; Kainic Acid; Male; Mice; Mice, Inbred Strains; Pent | 1994 |
Membrane lipid degradation is related to interictal cortical activity in a series of seizures.
Topics: Animals; Cerebral Cortex; Diglycerides; Electroencephalography; Fatty Acids, Nonesterified; Male; Me | 1994 |
Synthesis and anticonvulsant properties of some novel quinazolinone thiazolidine and 4-thiazolidone derivatives.
Topics: Animals; Anticonvulsants; Female; Male; Mice; Pentylenetetrazole; Quinazolines; Seizures; Spectropho | 1993 |
State-dependent stimulus control: cueing attributes of ethanol "hangover" in rats.
Topics: Animals; Arousal; Association Learning; Avoidance Learning; Chlordiazepoxide; Conditioning, Classica | 1993 |
Effect of acute alcohol withdrawal on sensitivity to pro- and anticonvulsant treatments in WSP mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Arousal; Convulsants; Diazepam; Dizocilpine M | 1993 |
Glial response to neuronal activity: GFAP-mRNA and protein levels are transiently increased in the hippocampus after seizures.
Topics: Animals; Blotting, Western; Electrodes, Implanted; Electroshock; Gene Expression; Glial Fibrillary A | 1993 |
Vigabatrin as an anticonvulsant against pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; gamma-Aminobutyr | 1993 |
Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid.
Topics: Animals; Diazepam; Drug Synergism; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pent | 1994 |
Pro and anticonvulsant effects of xylazine on convulsion models in rodents.
Topics: Amphetamine; Animals; Anticonvulsants; Convulsants; Electroshock; Female; Male; Mice; Pentylenetetra | 1994 |
Imidazenil, a new partial agonist of benzodiazepine receptors, reverses the inhibitory action of isoniazid and stress on gamma-aminobutyric acidA receptor function.
Topics: Animals; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds | 1994 |
Pentylenetetrazole-induced seizures stimulate transcription of early and late response genes.
Topics: Animals; Genes, Immediate-Early; Hippocampus; Male; Neuropeptides; Pentylenetetrazole; Rats; Rats, S | 1994 |
Experimental seizures in the frog (Rana pipiens).
Topics: Animals; Behavior, Animal; Bicuculline; Brain; Cisplatin; Convulsants; Electroencephalography; Kaini | 1994 |
Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine.
Topics: Animals; Disease Models, Animal; Injections, Intramuscular; Injections, Intravenous; Midazolam; Pent | 1994 |
Anticonvulsive effects of inhaling lavender oil vapour.
Topics: Administration, Inhalation; Animals; Anticonvulsants; Lavandula; Male; Mice; Nicotine; Oils, Volatil | 1994 |
Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Body Temperat | 1993 |
Free fatty acid and diacylglycerol accumulation in the rat brain during recurrent seizures is related to cortical oxygenation.
Topics: Animals; Arachidonic Acid; Carbon Dioxide; Cerebral Cortex; Diglycerides; Electroencephalography; El | 1993 |
Expression of the mas proto-oncogene in the rat hippocampal formation is regulated by neuronal activity.
Topics: Animals; Gene Expression; Hippocampus; In Situ Hybridization; Neoplasm Proteins; Neurons; Pentylenet | 1993 |
Changes in the threshold of pentylenetetrazol-induced seizures in cats with a chronic granuloma in brain amygdala.
Topics: Amygdala; Animals; Brain Diseases; Cats; Granuloma; Kaolin; Male; Pentylenetetrazole; Seizures; Tomo | 1993 |
Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Drug To | 1993 |
Acute down-regulation of oxytocin and vasopressin mRNA levels following metrazole-induced seizure in the rat.
Topics: Animals; Blotting, Northern; Cell Nucleus; Enkephalins; Gene Expression; Hypothalamus; Male; Oxytoci | 1993 |
Synthesis and anticonvulsant activity of 1,3-dihydro-5-phenyl-2H-pyrido[3,2-e]-1,4-diazepin-2-ones.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Evaluation, Preclinical; Mice; Pentylenetetrazole; Pyrid | 1993 |
The susceptibility of pentylenetetrazole-induced seizure in rats with hippocampal lesion induced by trimethyltin.
Topics: Administration, Oral; Animals; Dizocilpine Maleate; Hippocampus; Male; Neurons; Pentylenetetrazole; | 1993 |
Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain.
Topics: Animals; Brain; Differential Threshold; Electroshock; Escape Reaction; Immunohistochemistry; Learnin | 1993 |
Type I corticosteroid receptors modulate PTZ-induced convulsions of withdrawal seizure prone mice.
Topics: Aminoglutethimide; Animals; Desoxycorticosterone; Dexamethasone; Disease Susceptibility; Ethanol; Ma | 1993 |
Nitric oxide contributes to dilatation of cerebral arterioles during seizures.
Topics: Acetylcholine; Animals; Arginine; Arterioles; Blood Pressure; Cerebrovascular Circulation; Nitric Ox | 1993 |
Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nervou | 1993 |
Ethanol- and diazepam-withdrawal hyperlocomotion is not due to 5-HT3 receptor stimulation.
Topics: Animals; Diazepam; Ethanol; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Re | 1993 |
Rapid dephosphorylation of microtubule-associated protein 2 in the rat brain hippocampus after pentylenetetrazole-induced seizures.
Topics: Animals; Hippocampus; Male; Microtubule-Associated Proteins; Pentylenetetrazole; Phosphorylation; Ra | 1993 |
Pentylenetetrazol seizures increase pro-nerve growth factor-like immunoreactivity in the reticular thalamic nucleus and nerve growth factor mRNA in the dentate gyrus.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cricetinae; Female; Hippocampus; Immunohisto | 1993 |
The anticonvulsant activity of D-cycloserine is specific for tonic convulsions.
Topics: Animals; Anticonvulsants; Cycloserine; Electric Stimulation; Electroencephalography; Hippocampus; Ki | 1993 |
Chronic L-lysine develops anti-pentylenetetrazol tolerance and reduces synaptic GABAergic sensitivity.
Topics: Animals; Binding, Competitive; Brain; Chloride Channels; Chromatography, High Pressure Liquid; Drug | 1993 |
Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; GABA-A R | 1993 |
The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Dose-Response Relationship, Drug; Drug Tole | 1993 |
Involvement of brain serotonergic function in lidocaine-induced convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Cerebral Cortex; Electric Stimulation; Lidocaine; Male; Mice; N | 1993 |
Anticonvulsant effects of extracts of the west African black pepper, Piper guineense.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Ethanol; Male; Medicine, African Traditional; Mice; | 1993 |
Effects of water immersion stress on convulsions induced by pentylenetetrazol.
Topics: Animals; Corticosterone; Immersion; Male; Pentylenetetrazole; Radioimmunoassay; Rats; Rats, Sprague- | 1993 |
Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation.
Topics: 3T3 Cells; Animals; Brain; Electric Stimulation; Electrophysiology; Enzyme Induction; Gene Expressio | 1993 |
Pharmacological properties of a new fluoroquinolone on the central nervous system in rodents.
Topics: Animals; Anti-Infective Agents; Behavior, Animal; Bicuculline; Body Temperature; Central Nervous Sys | 1993 |
Anticonvulsant activity of flumazenil in rats during ontogenetic development.
Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; F | 1993 |
Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice.
Topics: Acoustic Stimulation; Animals; Carbonic Anhydrases; Disease Susceptibility; Epilepsy, Tonic-Clonic; | 1993 |
Increases in brain polyamine concentrations in chemical kindling and single convulsion induced by pentylenetetrazol in rats.
Topics: Animals; Brain; Kindling, Neurologic; Male; Osmolar Concentration; Pentylenetetrazole; Putrescine; R | 1993 |
Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Ethosuxim | 1993 |
Protective effect of flunarizine and nifedipine alone and in combination with anticonvulsant drugs against PTZ-induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Ethosu | 1993 |
Differences in c-fos immunoreactivity due to age and mode of seizure induction.
Topics: Aging; Animals; Flurothyl; Hypoxia; Immunohistochemistry; Pentylenetetrazole; Proto-Oncogene Protein | 1993 |
[The effect of superoxide dismutase on seizures in an experimental rat model of epilepsy].
Topics: Animals; Convulsants; Disease Models, Animal; Electric Stimulation; Electroencephalography; Kindling | 1995 |
Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Ethosuxim | 1995 |
Search for new anticonvulsant compounds. Part 1: Synthesis, physicochemical and anticonvulsant properties of new derivatives of alpha-amino-gamma-phthalimidobutyric acid.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Electroshock; Mice; Pentylenetetr | 1995 |
Anticonvulsant activity of aryl and hetarylsulfonylhydrazones.
Topics: Animals; Anticonvulsants; Body Temperature; Electroshock; Female; Hydrazones; Hypnotics and Sedative | 1995 |
Stereoselective anticonvulsant activity of the enantiomers of (+/-)-2-hydroxy-2-phenylbutyramide.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Male; Mice; Pentylenetetrazole; Phen | 1995 |
Anticonvulsant semicarbazones: are aryl groups necessary for activity?
Topics: Animals; Anticonvulsants; Electroshock; Pentylenetetrazole; Rats; Seizures; Semicarbazones; Structur | 1995 |
Flunarizine--its effect on pentylenetetrazol-kindled seizures and on related cognitive disturbances.
Topics: Animals; Dose-Response Relationship, Drug; Flunarizine; Kindling, Neurologic; Learning; Male; Pentyl | 1995 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. The action of kynurenic acid and glutamic acid diethylester.
Topics: Age Factors; Animals; Disease Models, Animal; Glutamic Acid; Kynurenic Acid; Male; Pentylenetetrazol | 1995 |
Increase of central nitric oxide during pentylenetetrazol-induced seizures in rats.
Topics: Animals; Biosensing Techniques; Convulsants; Injections, Intraperitoneal; Male; Nitric Oxide; Pentyl | 1995 |
Increase in activin beta A mRNA in rat hippocampus during long-term potentiation.
Topics: Activins; Animals; Base Sequence; Convulsants; Dentate Gyrus; Electric Stimulation; Excitatory Amino | 1996 |
Glottal patency during experimental seizures in piglets.
Topics: Analysis of Variance; Animals; Anticonvulsants; Blood Gas Analysis; Glottis; Hyperoxia; Pentylenetet | 1995 |
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y.
Topics: Animals; Body Weight; Eating; Feeding Behavior; Female; Food Deprivation; GABA Antagonists; Gene Tar | 1996 |
Chronic malnutrition caused by a corn-based diet lowers the threshold for pentylenetetrazol-induced seizures in rats.
Topics: Animals; Body Weight; Brain; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; | 1996 |
Molecular characterization of seizure-related genes isolated by differential screening.
Topics: Amino Acid Sequence; Animals; Calcium; Carrier Proteins; Cells, Cultured; Cloning, Molecular; DNA, C | 1996 |
The effects of a single neonatally induced convulsion on spatial navigation, locomotor activity and convulsion susceptibility in the adult rat.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Disease Susceptibility; Hot Temperature; Mal | 1996 |
Structural modifications of the primary amino group of anticonvulsant aryl semicarbazones.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Electroshock; Hydrogen Bonding; Molecular Conforma | 1996 |
Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.
Topics: Acetates; Acetic Acid; Analgesics; Analysis of Variance; Animals; Anticonvulsants; Body Temperature; | 1996 |
The effects of malignant glioma on the EEG and seizure thresholds: an experimental study.
Topics: Adult; Animals; Brain Mapping; Cell Line; Cerebral Cortex; Convulsants; Electroencephalography; Evok | 1996 |
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamates; Dyskinesi | 1996 |
Nootropic drugs have different effects on kindling-induced learning deficits in rats.
Topics: Animals; Avoidance Learning; Convulsants; Kindling, Neurologic; Learning; Learning Disabilities; Mal | 1995 |
Effects of repeated administration of selective adenosine A1 and A2A receptor agonists on pentylenetetrazole-induced convulsions in the rat.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Dose-Response Relationship, | 1995 |
Indispensable amino acid deficiency and increased seizure susceptibility in rats.
Topics: Amino Acids; Animals; Bicuculline; Differential Threshold; Disease Susceptibility; Drug Administrati | 1996 |
Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Baclofen; Dose-Response Relationship, Drug; Epilepsy, Tonic- | 1996 |
Effects of single cyclosporin A pretreatment on pentylenetetrazol-induced convulsion and on TRE-binding activity in the rat brain.
Topics: Amygdala; Animals; Base Sequence; Brain; Cyclosporine; DNA-Binding Proteins; Electrophoresis, Polyac | 1995 |
Chronic and single administration of pentylenetetrazol modifies benzodiazepine receptor-binding: an autoradiographic study.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Convulsants; Densitometry; Flunitrazepam; Male; Penty | 1996 |
Arrest of seizure progression during electrical kindling in guinea-pigs with prior pentylenetetrazol-induced convulsions.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Electroencephalography; Female; Guinea Pigs; Kindling | 1996 |
Responses of electrical activity and redox state of cytochrome oxidase to oxygen insufficiency in perfused rat brain in situ.
Topics: Adenosine Triphosphate; Animals; Brain; Convulsants; Electroencephalography; Electron Transport Comp | 1996 |
Functional correlation between allopregnanolone and [35S]-TBPS binding in the brain of rats exposed to isoniazid, pentylenetetrazol or stress.
Topics: Animals; Antitubercular Agents; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsant | 1996 |
3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cell Membrane; Cerebral Cortex; Drug Synergism; Ethanol; | 1996 |
Acute and chronic effects of melatonin as an anticonvulsant in male gerbils.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Dose-Response Relationship, Drug; Gerbillinae; Male; Mel | 1996 |
A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures.
Topics: Animals; Brain Chemistry; Carbolines; Convulsants; Drug Resistance; Evaluation Studies as Topic; Fem | 1996 |
(Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen.
Topics: Animals; Anticonvulsants; Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; D | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diaze | 1996 |
Moderate anticonvulsant action of baclofen does not change during development.
Topics: Animals; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; Male; Pentylene | 1996 |
Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice.
Topics: Animals; Arginine; Bicuculline; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Pent | 1996 |
Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Clonazepam; Drug Interactions; Ethosuximide; Flu | 1996 |
Binding of double stranded oligonucleotide probes for particular transcription factors with leucine-zipper motifs in discrete brain structures of mice with acquired and inherent spontaneous seizures.
Topics: Activating Transcription Factor 2; Animals; Area Under Curve; Brain; Brain Chemistry; Convulsants; C | 1996 |
Evaluation of the calcium-antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia.
Topics: Administration, Oral; Analysis of Variance; Animals; Antidiarrheals; Calcium; Convulsants; Dose-Resp | 1996 |
Synthesis and anticonvulsant activity of some amino acid derivatives. Part 1: alanine derivatives.
Topics: Acetylation; Alanine; Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Convulsants | 1996 |
Comparison of the pharmacological profiles of the hypnotic drugs, zaleplon and zolpidem.
Topics: Acetamides; Analysis of Variance; Animals; Chlordiazepoxide; Convulsants; Discrimination Learning; E | 1996 |
The role of nitric oxide in chemically- and electrically-induced seizures in mice.
Topics: Animals; Convulsants; Electroshock; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Ma | 1996 |
Vagus nerve stimulation induces a sustained anticonvulsant effect.
Topics: Animals; Electric Stimulation Therapy; Electroencephalography; Humans; Male; Pentylenetetrazole; Rat | 1996 |
Effects of non-peptide angiotensin II-receptor antagonists on pentylenetetrazol kindling in mice.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anticonvulsants; Biphenyl Compounds; Conv | 1996 |
Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats.
Topics: Animals; Anticonvulsants; Blood Glucose; Convulsants; Drug Evaluation, Preclinical; Glucose; Hypogly | 1996 |
Chronic seizures increase glucose transporter abundance in rat brain.
Topics: Animals; Brain; Chronic Disease; Glucose Transporter Type 1; Glucose Transporter Type 3; Immunoblott | 1996 |
Repeated postnatal phencyclidine administration in female juvenile rat delays onset of puberty but has no effect on pentylenetetrazol-induced seizure-susceptibility.
Topics: Animals; Animals, Newborn; Disease Susceptibility; Estrus; Female; Ovulation; Pentylenetetrazole; Ph | 1995 |
Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.
Topics: Animals; Bicuculline; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Protein-Tyrosine K | 1996 |
Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding.
Topics: Animals; Autoradiography; Behavior, Animal; Bicuculline; Brain; Caffeine; Disease Susceptibility; Ma | 1996 |
NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice.
Topics: Aminooxyacetic Acid; Aminophylline; Animals; Convulsants; Drug Synergism; Electroshock; Enzyme Inhib | 1996 |
Structure-activity relationships of 2-aryl-2,5-dihydropyridazino [4,3-b]indol-3(3H)-ones at the benzodiazepine receptor.
Topics: Animals; Anticonvulsants; Computer Simulation; Dose-Response Relationship, Drug; Hydrogen Bonding; I | 1996 |
Genetic differences in behavioral sensitivity to a neuroactive steroid.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Ataxia; Avoidance Learning; Dose-Response Relationshi | 1997 |
Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.
Topics: Animals; Brain Chemistry; Cerebellum; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA | 1997 |
NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
Topics: 4-Aminopyridine; Alanine; Animals; Behavior, Animal; Cerebellum; Convulsants; Cyclic GMP; Drug Inter | 1997 |
Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Anticonvulsants; Brain; Convulsants; Kindling, Neurologic; Male; | 1996 |
Enhancing effect of L-carnitine on some abnormal signs induced by pentylenetetrazol.
Topics: Animals; Blood-Brain Barrier; Carnitine; Convulsants; Male; Pentylenetetrazole; Rats; Rats, Wistar; | 1996 |
Suppression of pentylenetetrazol-induced seizures by carnitine in mice.
Topics: Animals; Brain; Carnitine; Dose-Response Relationship, Drug; Energy Metabolism; Male; Mice; Pentylen | 1997 |
1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats.
Topics: Adenosine; Animals; Blood Pressure; Body Temperature; Heart Rate; Male; Pentylenetetrazole; Rats; Ra | 1997 |
Synthesis, structures and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives. Part 2.
Topics: Amphetamine; Animals; Anticonvulsants; Carboxylic Acids; Central Nervous System Agents; Central Nerv | 1997 |
L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice.
Topics: Animals; Convulsants; Drug Evaluation, Preclinical; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine | 1997 |
Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug I | 1997 |
The leaf essential oil of Psidium guyanensis offers protection against pentylenetetrazole-induced seizures.
Topics: Animals; Anticonvulsants; Anura; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Skelet | 1997 |
Pentylenetetrazol and strychnine convulsions in brain weight selected mice.
Topics: Animals; Brain; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; Electroencephalograp | 1997 |
Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats.
Topics: Adenosine Triphosphate; Aging; Animals; Brain; Brain Chemistry; Creatine Kinase; Electroencephalogra | 1997 |
Sensitivity to jerky gene dosage underlies epileptic seizures in mice.
Topics: Aging; Alleles; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; Disease Susceptibility; DNA Pr | 1997 |
Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.
Topics: Anesthesia; Animals; Anticonvulsants; Bicuculline; Calcium; Cerebellum; Electroshock; Mice; Models, | 1997 |
Dextromethorphan ameliorates effects of neonatal hypoxia on brain morphology and seizure threshold in rats.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Brain; Cerebral Cortex; | 1997 |
Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.
Topics: Animals; Asparagine; Aspartic Acid; Body Weight; Death, Sudden; DNA Primers; Female; Growth Disorder | 1997 |
Anticonvulsant and neurotoxicological properties of 4-amino-N-(2-ethylphenyl)benzamide, a potent ameltolide analogue.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzamides; Convulsants; Dose-Response Relationship, | 1997 |
Effects of [arginine8, glycine-OH9]-vasopressin on pentylenetetrazol seizures in mice. Interaction with adrenaline.
Topics: Animals; Arginine Vasopressin; Convulsants; Drug Synergism; Epinephrine; Male; Mice; Neurotransmitte | 1997 |
Anxiolytic-like effects of PNU-101017, a partial agonist at the benzodiazepine receptor.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Cells, Cultured; Cerebellum; Conflict, Psychologic | 1997 |
Molecular mechanism of regulation of pentylenetetrazol-induced calcium entry by 3'-untranslated region of a seizure-related cDNA, PTZ-17, in Xenopus oocytes.
Topics: Animals; Brain; Calcium; DNA, Complementary; Mice; Oocytes; Pentylenetetrazole; RNA; Seizures; Xenop | 1997 |
Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbolines; Cell Line; Convulsants; Flumazenil; GABA Modu | 1997 |
Chinese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese | 1997 |
Comparative in vivo and in vitro studies with the potent GABAB receptor antagonist, CGP 56999A.
Topics: Animals; Baclofen; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; Drug Interactions | 1997 |
Effect of alprazolam and ketamine on seizures induced by two different convulsants.
Topics: Alprazolam; Animals; Anticonvulsants; Aziridines; Convulsants; Ketamine; Male; Pentylenetetrazole; R | 1997 |
Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold.
Topics: Animals; Anticonvulsants; Brain; Cells, Cultured; Chloride Channels; Convulsants; Drug Synergism; Fl | 1997 |
Preliminary evaluation of the anticonvulsant activity of a valproic acid analog: N-(2-propylpentanoyl) urea.
Topics: Animals; Anticonvulsants; Bicuculline; Central Nervous System; Convulsants; Dose-Response Relationsh | 1997 |
The anticonvulsant effect of deprenyl on pentylenetetrazol-induced seizures in Lewis rats.
Topics: Animals; Anticonvulsants; Convulsants; Male; Pentylenetetrazole; Rats; Rats, Inbred Lew; Seizures; S | 1997 |
Melanin-concentrating hormone (MCH) involvement in pentylenetetrazole (PTZ)-induced seizure in rat and guinea pig.
Topics: Animals; Convulsants; Female; Guinea Pigs; Hypothalamic Hormones; Male; Melanins; Neurons; Oxidopami | 1997 |
Experimental study of the anticonvulsant plants used for treatment of infantile convulsion in Nigeria.
Topics: Animals; Anticonvulsants; Child; Electroshock; Female; Humans; Infant; Lethal Dose 50; Male; Medicin | 1997 |
Brain cortex Na(+)-K+ ATPase activities in streptozotocin-diabetic and pentylenetetrazol-epileptic rats.
Topics: Animals; Cerebral Cortex; Convulsants; Diabetes Mellitus, Experimental; Epilepsy; Pentylenetetrazole | 1997 |
2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives: novel, potent and selective sigma1 receptor ligands.
Topics: Animals; Anticonvulsants; Benzoxazoles; Brain; Convulsants; Electroshock; Guinea Pigs; Ligands; Male | 1997 |
A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats.
Topics: Aminophylline; Animals; Bronchodilator Agents; Convulsants; Disease Models, Animal; Drug Interaction | 1997 |
Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro.
Topics: Alcoholism; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Convulsants; Excitatory Postsy | 1997 |
The NMDA receptor competitive antagonist CPP modulates benzodiazepine tolerance and discontinuation.
Topics: Animals; Cerebral Cortex; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Hipp | 1997 |
Activation of the GABA(A)-receptor delta-subunit gene promoter following pentylenetetrazole-induced seizures in transgenic mice.
Topics: Animals; beta-Galactosidase; Brain; Gene Expression Regulation; Kindling, Neurologic; Mice; Mice, In | 1997 |
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
Topics: 3-Mercaptopropionic Acid; Amides; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electr | 1998 |
Synthesis, anticonvulsant activity, and structure-activity relationships of sodium channel blocking 3-aminopyrroles.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Indicators and Reagents; M | 1998 |
Synthesis and anticonvulsant activity of new thiazolidinone and thioxoimidazolidinone derivatives derived from furochromones.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Convulsants; Imidazoles; Khellin; | 1997 |
In vivo phosphocreatine and ATP in piglet cerebral gray and white matter during seizures.
Topics: Adenosine Triphosphate; Animals; Brain; Catalysis; Creatine Kinase; Magnetic Resonance Spectroscopy; | 1998 |
T3 deficiency prolongs convulsions induced by acute pentylenetetrazole.
Topics: Animals; Antithyroid Agents; Colon; Convulsants; Drug Overdose; Male; Methimazole; Pentylenetetrazol | 1997 |
Pentylenetetrazol seizure threshold in the rat during recovery phase from propofol and thiopentone induced anesthesia.
Topics: Anesthesia, General; Anesthetics, General; Animals; Behavior, Animal; Convulsants; Female; Motor Act | 1997 |
[Possible role of nitric oxide in pathogenesis of model seizure of the different etiology].
Topics: Animals; Brain; Convulsants; Electron Spin Resonance Spectroscopy; Electroshock; Excitatory Amino Ac | 1998 |
Dose-related proconvulsant and anticonvulsant activity of isatin, a putative biological factor, in rats.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; F | 1998 |
Differential changes in induced seizures after hippocampal treatment of rats with an antisense oligodeoxynucleotide to the GABA(A) receptor gamma2 subunit.
Topics: Animals; Avoidance Learning; Convulsants; Electroshock; Handling, Psychological; Hippocampus; Interp | 1997 |
Sensitisation of withdrawal signs following repeated withdrawal from a benzodiazepine: differences between measures of anxiety and seizure sensitivity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Conflict, Psychological | 1998 |
Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Dinoprost; Epilepsy, Tonic-Clonic; Injections, Intrav | 1998 |
Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Convulsants; Diazepam; Excitatory Amino A | 1998 |
Further studies on anti- and proconvulsant effects of inhibitors of nitric oxide synthase in rodents.
Topics: Animals; Anticonvulsants; Convulsants; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; | 1998 |
Role of nitric oxide in the hypersusceptibility to pentylenetetrazole-induced seizure in diazepam-withdrawn mice.
Topics: Animals; Arginine; Diazepam; Enzyme Inhibitors; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nit | 1998 |
Dose-finding study with nimodipine: a selective central nervous system calcium channel blocker on aminophylline induced seizure models in rats.
Topics: Aminophylline; Animals; Anticonvulsants; Calcium Channel Blockers; Dose-Response Relationship, Drug; | 1998 |
Biosynthesis and metabolism of native and oxidized neuropeptide Y in the hippocampal mossy fiber system.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Biological Transport; Hippocampus; Immunologic T | 1998 |
Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid | 1998 |
Anticonvulsant action of gabapentin during postnatal development in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Do | 1997 |
Aminoalkanolic derivatives of xanthone with potential antiepileptic activity.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Electroshock; Magnetic Resonance | 1998 |
Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Drug Toleran | 1998 |
Differential expression of c-fos mRNA and Fos protein in the rat brain after restraint stress or pentylenetetrazol-induced seizures.
Topics: Animals; Brain; Gene Expression Regulation; Genes, fos; Immobilization; Immunohistochemistry; In Sit | 1998 |
Age-dependent regulation of seizure activity by nitric oxide in the developing rat.
Topics: Aging; Animals; Enzyme Inhibitors; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pentylenetetr | 1998 |
Synthesis and pharmacological evaluation of a new homologous series of (+/-)-p-fluoro-phenyl alcohol amide anticonvulsants.
Topics: Amides; Animals; Anticonvulsants; Butyrates; Caproates; Convulsants; Injections, Intraperitoneal; Ma | 1998 |
Effects of misoprostol on pentylenetetrazol-induced seizures in mice.
Topics: Abortifacient Agents, Nonsteroidal; Animals; Convulsants; Female; Mice; Misoprostol; Pentylenetetraz | 1997 |
GYKI 52466 [1-(4-aminophenyl)-4-methoxy-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] and the anticonvulsive activity of conventional antiepileptics against pentetrazol in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Benzodiazepines; Convulsants; Dru | 1998 |
[Effect of calcium channel blocker nifedipine on anxiety and seizure manifestations of abstinence syndrome in rats after withdrawal of long-term diazepam administration].
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Anxiety; Calcium Channel Blockers; Calcium | 1998 |
Qualitative changes of anticonvulsant action of felbamate during development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Fe | 1998 |
Crystal structure of 180 degree K of bis-3, 5-diisopropylsalicylatobisdimethylsulfoxidozinc(II) and the inhibition of seizures and polymorphonuclear leukocyte chemiluminescence.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Dimethyl Sulfoxide; Electroshock; Luminescent Meas | 1998 |
Prenatal cocaine exposure increases susceptibility to drug-induced seizures. c-fos induction and brain cocaine levels.
Topics: Animals; Brain; Cocaine; Disease Susceptibility; Female; Gene Expression Regulation; Male; Pentylene | 1998 |
Evaluation of some 2-substituted derivatives of xanthone for anticonvulsant properties.
Topics: Animals; Anticonvulsants; Chromatography, Thin Layer; Convulsants; Electroshock; Injections, Intrape | 1998 |
Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Agonists; Calcium Channel Blockers; Clonazepam; Dihydropyr | 1998 |
Ontogeny of ethosuximide action against two seizure models in rats is different.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Ethosux | 1998 |
Protective effect of clozapine against pentylenetetrazol convulsions and kindling.
Topics: Animals; Antipsychotic Agents; Clozapine; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Mal | 1998 |
Central inhibitory effects of water extract of Acori graminei rhizoma in mice.
Topics: Animals; Apomorphine; Central Nervous System; Dose-Response Relationship, Drug; Drugs, Chinese Herba | 1998 |
Time development and regional distribution of [3H]nitrobenzylthioinosine adenosine uptake site binding in the mouse brain after acute Pentylenetetrazol-induced seizures.
Topics: Adenosine; Affinity Labels; Animals; Autoradiography; Binding Sites; Brain; Cell Membrane; Cerebellu | 1998 |
Deficient sensorimotor gating following seizures in amygdala-kindled rats.
Topics: Acoustic Stimulation; Amygdala; Analysis of Variance; Animals; Cues; Disease Models, Animal; Electri | 1998 |
A potential anti-asthmatic drug, CR 2039, enhances the anticonvulsive activity of some antiepileptic drugs against pentetrazol in mice.
Topics: Animals; Anticonvulsants; Benzamides; Bronchodilator Agents; Clonazepam; Convulsants; Dose-Response | 1998 |
3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1998 |
Acid-catalysed hydrolysis and benzodiazepine-like properties of 5-(dialkylamino)- and 5-(alkylthio)-substituted 8-chloro-6-phenyl-6H-[1,2,4]triazolol[4,3-a][1,5]benzodiazepines in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzodiazepines; Brain; Gastric Acid; Hydrolysis; Ma | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
Anticonvulsant effect of progabide in rats during ontogenesis.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Convulsants; gamma-Aminobutyric Acid; Male; Penty | 1997 |
Anticonvulsant effect of SL 75 102 in adult and immature rats.
Topics: Aging; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Pentylenetetrazole; Rats; Seizures | 1997 |
Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 1998 |
Synthesis of a new homologous series of p-chlorophenyl alcohol amides, their anticonvulsant activity and their testing as potential GABAB receptor antagonists.
Topics: Amides; Animals; Anticonvulsants; Baclofen; Convulsants; GABA-B Receptor Antagonists; Injections, In | 1998 |
Mapping of neuronal networks underlying generalized seizures induced by increasing doses of pentylenetetrazol in the immature and adult rat: a c-Fos immunohistochemical study.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Electroencepha | 1998 |
Asymmetrical changes in blood-brain barrier permeability during pentylenetetrazol-induced seizures and in acute hypertension.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Capillary Permeability; Convulsants; Female; Functiona | 1998 |
Repeated ethanol withdrawal experience selectively alters sensitivity to different chemoconvulsant drugs in mice.
Topics: Animals; Body Weight; Convulsants; Ethanol; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inb | 1998 |
Pharmacological characterization of 6-bromo-3'-nitroflavone, a synthetic flavonoid with high affinity for the benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Flavonoids; GABA-A Receptor Agonists; Male; Maze L | 1998 |
Synthesis and anticonvulsant activity of some 2-N-(phthalimido)-1-alkyl esters.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Mice; Pentylenetetrazole; Phthalimides; Seizure | 1998 |
Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroencephalograp | 1998 |
Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis.
Topics: Animals; Anticonvulsants; Benzoates; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Gluco | 1998 |
[Effect of cerebral ischemia of various severity on acute seizures and chronic epileptogenesis].
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Brain Ischemia; Carotid Artery Diseases; Chroni | 1998 |
Antiepileptic effects of NPY on pentylenetetrazole seizures.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Humans; Injections, Intraventricular; | 1998 |
The effect of pentylenetetrazol kindling on synaptic mechanisms of interacting glutamatergic and opioid system in the hippocampus of rats.
Topics: Animals; Convulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techni | 1998 |
[Effect of carotid glomectomy on seizures induced by corasol].
Topics: Acute Disease; Animals; Carotid Body; Convulsants; Hypoxia; Male; Pentylenetetrazole; Rats; Reflex; | 1998 |
Repeated exposure to trimethylolpropane phosphate induces central nervous system sensitization and facilitates electrical kindling.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Central Nervous System; Convulsants; E | 1998 |
Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Differential Threshold; Electroshock; His | 1998 |
Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents.
Topics: Animals; Drug Interactions; Electric Stimulation; Indoles; Male; Mice; Pentylenetetrazole; Pyridines | 1998 |
[Influence of co-administered antiepileptic drugs on nitrazepam tolerance in mice].
Topics: Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Drug Interactions; Drug Therapy, | 1998 |
Consequences of neonatal seizures in the rat: morphological and behavioral effects.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Bromodeoxyuridine; Cell Count; Convulsants; Diff | 1998 |
Genotyping microsatellite polymorphisms by agarose gel electrophoresis with ethidium bromide staining: application to quantitative trait loci analysis of seizure susceptibility in mice.
Topics: Animals; Chromosome Mapping; Convulsants; Crosses, Genetic; DNA; Drug Resistance; Electrophoresis, A | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mic | 1999 |
Modulation of pentylenetetrazol-induced seizure activity by branched-chain amino acids and alpha-ketoisocaproate.
Topics: Amino Acids, Branched-Chain; Animals; Caproates; Electroencephalography; Injections, Intraventricula | 1999 |
Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice.
Topics: Animals; Cerebral Ventricles; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Indans; Infu | 1998 |
Anticonvulsant efficacy of L-deprenyl (selegiline) during chronic treatment in mice: continuous versus discontinuous administration.
Topics: Animals; Anticonvulsants; Drug Administration Schedule; Infusions, Intravenous; Infusions, Parentera | 1998 |
Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice.
Topics: Animals; Anticonvulsants; Cholestenone 5 alpha-Reductase; Convulsants; Drug Interactions; Electrosho | 1999 |
Galanin controls excitability of the brain.
Topics: Animals; Brain; Cerebral Ventricles; Convulsants; Galanin; Glutamic Acid; Injections, Intraventricul | 1998 |
Influence of ethanol on the pentylenetetrazol-induced kindling in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Ethanol; Kindling, Neurologic; Male; Pen | 1998 |
A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Epileps | 1999 |
Lorazepam attenuates the behavioral effects of dizocilpine.
Topics: Animals; Dizocilpine Maleate; Drug Antagonism; Excitatory Amino Acid Antagonists; GABA Modulators; L | 1999 |
Mossy fiber sprouting after recurrent seizures during early development in rats.
Topics: Animals; Behavior, Animal; Cell Count; Coloring Agents; Convulsants; Dentate Gyrus; Hippocampus; His | 1999 |
Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives.
Topics: Animals; Anticonvulsants; Ataxia; Chromatography, High Pressure Liquid; Convulsants; Cross-Over Stud | 1999 |
Involvement of tumor necrosis factor alpha and interleukin-1beta in enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae.
Topics: Animals; Blood-Brain Barrier; Dysentery, Bacillary; Interleukin-1; Male; Mice; Mice, Inbred ICR; Pen | 1999 |
Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Blepharoptosis; | 1998 |
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.
Topics: Animals; Animals, Newborn; Apoptosis; Base Sequence; Cell Division; Excitatory Amino Acid Agonists; | 1999 |
N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Interactions; Enzyme Inhibitors; Eth | 1999 |
Design, anticonvulsive and neurotoxic properties of retrobenzamides. N-(Nitrophenyl)benzamides and N-(aminophenyl)benzamides.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzamides; Convulsants; Drug Design; Electroshock; | 1999 |
Effects of enadoline on the development of pentylenetetrazol kindling, learning performance, and hippocampal morphology.
Topics: Animals; Benzofurans; Convulsants; Glutamic Acid; Hippocampus; Kindling, Neurologic; Learning; Male; | 1999 |
[Nitric oxide in the rat cerebral cortex in seizure models: potential ways of pharmacological modulation].
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Dizocilpine Maleate; Electron Spin Resonance Spectr | 1998 |
Cerebral seizure susceptibility and patterns of paroxysmal activity during embryonic development in the domestic chicken.
Topics: Animals; Anticonvulsants; Chick Embryo; Convulsants; Electroencephalography; Glutamic Acid; Methioni | 1973 |
Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Evaluation Studies as Topic; | 1999 |
Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Biological Availability; Cell Line; Cerebell | 1999 |
Role of metabotropic glutamate receptors in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Drug Interactions; Injections, Intraventricu | 1999 |
Absence epilepsy and regional blood-brain barrier permeability: the effects of pentylenetetrazole-induced convulsions.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Epilepsy, Absence; Male; Pentylenetetrazole; P | 1999 |
Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Interactions; Male; Pentylenetetrazole; Protec | 1997 |
Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Behavior, Animal; Convulsants; Diet; Energy Intake; Growth; K | 1999 |
Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine.
Topics: Adenosine; Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Combinations; Male; Pentylenet | 1999 |
Pentylenetetrazol-induced seizures increase [3H]L-2-amino-4-phosphonobutyrate binding in discrete regions of the rat brain.
Topics: Aminobutyrates; Animals; Anticonvulsants; Autoradiography; Brain; Brain Chemistry; Convulsants; Fema | 1999 |
Histamine H2-receptor modulation in two mouse models of seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzothiazoles; Convulsants; Dimaprit; Female; Hista | 1999 |
Efficacy of shitei-to, a traditional Chinese medicine formulation, against convulsions in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Drugs, Chinese Herbal; Electroshock; Male; Mice; | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine | 1999 |
Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis.
Topics: Analysis of Variance; Animals; Anticonvulsants; Benzoates; Bridged-Ring Compounds; Disease Models, A | 1999 |
Developmental changes in seizure susceptibility during ethanol withdrawal.
Topics: Age Factors; Animals; Body Weight; Central Nervous System Depressants; Convulsants; Ethanol; Pentyle | 1999 |
Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anti-Infective Agents; Electroencephalography; Fluoroquinolones; Male; Mice; Mice, Inbred I | 1999 |
gamma-Aminobutyrate-A receptor modulation by 3-aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain Stem; Cerebellum; Cerebral Cortex; GABA Ag | 1999 |
Reversal by flunarizine of the decrease in hippocampal acetylcholine release in pentylenetetrazole-kindled rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Calcium; Convulsants; Disease Models, | 1999 |
Ultrawideband radiation and pentylenetetrazol-induced convulsions in rats.
Topics: Animals; Convulsants; Electromagnetic Fields; Male; Pentylenetetrazole; Radio Waves; Rats; Rats, Spr | 1999 |
Differential seizure-induced and developmental changes of neurexin expression.
Topics: Aging; Animals; Animals, Newborn; Gene Expression; Isomerism; Kainic Acid; Male; Nerve Tissue Protei | 1999 |
Convulsant actions of the neurosteroid pregnenolone sulfate in mice.
Topics: Animals; Convulsants; Disease Susceptibility; Drug Synergism; Injections, Intraventricular; Male; Mi | 1999 |
Forebrain ischemia: effect on pharmacologically induced seizure thresholds in the rat.
Topics: Analysis of Variance; Animals; Brain Ischemia; Convulsants; Lidocaine; Male; N-Methylaspartate; Pent | 1999 |
The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice.
Topics: Animals; Anticonvulsants; Apiaceae; Convulsants; Electroshock; Ethosuximide; Fruit; India; Iran; Let | 1999 |
Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice.
Topics: Animals; Chromosome Mapping; Convulsants; Female; Genetic Predisposition to Disease; Genome; Genotyp | 1999 |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists | 1999 |
Enhanced susceptibility of pentylenetetrazole kindled mice to quinolone effects.
Topics: Animals; Convulsants; GABA Antagonists; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylen | 1999 |
Synthesis, physicochemical and anticonvulsant properties of new N-pyridyl derivatives of 3-phenyl- and 3,3-diphenyl-succinimides.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Electroshock; Molecular Conformat | 1999 |
Involvement of delta-opioid receptors in pentylenetetrazol kindling development and kindling-related processes in rats.
Topics: Animals; Convulsants; Drug Interactions; Glutamic Acid; Injections, Intraventricular; Kindling, Neur | 1999 |
Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Avoidance Learning; Benzodiazepines; Clonazepam; Drug Sy | 1999 |
Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Convulsants; Hippocampus; In Si | 1999 |
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; | 1999 |
The effect of N-substituted alkyl groups on anticonvulsant activities of N-Cbz-alpha-amino-N-alkylglutarimides.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Convulsants; Electroshock; Glutarates; Male; Mice; Mice, | 1999 |
Effects of piracetam on pentylenetetrazol-kindling development, hippocampal potentiation phenomena and kindling-induced learning deficit.
Topics: Animals; Convulsants; Drug Interactions; Evoked Potentials; Hippocampus; Kindling, Neurologic; Learn | 1999 |
Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Behavior, Animal; Benzodiazepines; C | 1999 |
Role of nitric oxide in the enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae.
Topics: Animals; Convulsants; Dysentery, Bacillary; Enzyme Inhibitors; Male; Mice; Mice, Inbred ICR; Nitric | 1999 |
Formation of free hydroxyl radicals after pentylenetetrazol-induced seizure and kindling.
Topics: Animals; Brain; Convulsants; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Kindling, Neurologic; M | 1999 |
Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Body Weight; Convulsants; Diet; Differential Threshold; Disea | 1999 |
Low convulsive activity of a new carbapenem antibiotic, DK-35C, as compared with existing congeners.
Topics: Animals; Carbapenems; Cefazolin; Cephalosporins; GABA Agonists; Imipenem; Injections, Intraventricul | 1999 |
Anomalous expression of microtubule-associated protein 1B in the hippocampus and cortex of aged rats treated with pentylenetetrazole.
Topics: Aging; Animals; Blotting, Northern; Cerebral Cortex; Female; Gene Expression Regulation, Development | 1999 |
The anticonvulsive effect of glutathione in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Glutathione; Injections, Intraventricular; Male; Mice; N | 1999 |
The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; GABA-A Receptor Anta | 1999 |
Higher ketogenic diet ratios confer protection from seizures without neurotoxicity.
Topics: 3-Hydroxybutyric Acid; Animals; Basal Metabolism; Behavior, Animal; Convulsants; Diet; Dietary Fats; | 2000 |
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizoc | 2000 |
Effects of nicardipine, an antagonist of L-type voltage-dependent calcium channels, on kindling development, kindling-induced learning deficits and hippocampal potentiation phenomena.
Topics: Animals; Avoidance Learning; Calcium Channel Blockers; Calcium Channels, L-Type; Convulsants; Dentat | 1999 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knoc | 1999 |
Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Convulsants; Electroshock; Magnet | 1999 |
The anticonvulsant activities of N-benzyl 3-methoxypropionamides.
Topics: Acetamides; Amides; Animals; Anticonvulsants; Disease Models, Animal; Lacosamide; Mice; Pentylenetet | 1999 |
Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Male; | 1999 |
A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Convulsants; Diet, Reducing; Dietary Fats; Electroshock; | 2000 |
Seizure suppression by systemic epinephrine is mediated by the vagus nerve.
Topics: Afferent Pathways; Animals; Anticonvulsants; Convulsants; Epinephrine; Female; Pentylenetetrazole; R | 2000 |
A major effect QTL determined by multiple genes in epileptic EL mice.
Topics: Alleles; Animals; Disease Models, Animal; Epilepsy; Female; Genetic Markers; Homozygote; Male; Mice; | 2000 |
Involvement of nitric oxide in pentylenetetrazole-induced kindling in rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Convulsants; Hippocampus; Kindling, Neurologic; Male; Ne | 2000 |
Role of nitric oxide in electroshock and pentylenetetrazole seizure threshold in rats.
Topics: Animals; Arginine; Convulsants; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; F | 1999 |
The MCT ketogenic diet: effects on animal seizure models.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Body Weight; Dietary Fats, Unsaturated; Electroshock; M | 2000 |
Reduction of pentylenetetrazol-induced convulsions by the octadecaneuropeptide ODN.
Topics: Acoustic Stimulation; Amino Acid Sequence; Animals; Carbolines; Convulsants; Diazepam Binding Inhibi | 1999 |
Effects of the calcium antagonists verapamil and nitrendipine on carbamazepine withdrawal.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Convulsants; Male; Nitrendipine; | 1999 |
Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Chemotactic Factors; Convulsants; Dithionitrobenzoic Acid; Ep | 2000 |
The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats.
Topics: Animals; Convulsants; Extracellular Space; Frontal Lobe; Glutamic Acid; Kindling, Neurologic; Male; | 2000 |
Immature rat convulsions and long-term effects on hippocampal cholinergic neurotransmission.
Topics: Acetylcholine; Animals; Animals, Newborn; Cholinergic Fibers; Cholinesterase Inhibitors; Convulsants | 2000 |
Relationship between large conductance calcium-activated potassium channel and bursting activity.
Topics: Action Potentials; Animals; Apamin; Caffeine; Calcium; Cells, Cultured; Cerebral Cortex; Epilepsy; I | 2000 |
Roles of group II metabotropic glutamate receptors in modulation of seizure activity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Bridged Bicyclo Compounds; Convulsants; D | 2000 |
Modulatory role of neuropeptides in seizures induced in rats by stimulation of glutamate receptors.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Kainic Acid; Male; Neuropeptide Y; Neuropeptides; O | 2000 |
Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Cerebral Cortex; Convulsants; Electr | 2000 |
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological; | 2000 |
Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds.
Topics: Animals; Anticonvulsants; Drug Design; Electroshock; Hydrazones; Injections, Intraperitoneal; Mice; | 2000 |
Seizures and neuronal damage in mice lacking vesicular zinc.
Topics: Animals; Bicuculline; Carrier Proteins; Cation Transport Proteins; Convulsants; Dose-Response Relati | 2000 |
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurolo | 2000 |
Central action of some cytostatics--methotrexate (MTX) and doxorubicin (DXR). II. The influence on the seizure activity and the learning and memory processes in mice.
Topics: Animals; Brain; Doxorubicin; Drug Interactions; Female; gamma-Aminobutyric Acid; Hexobarbital; Learn | 1998 |
Design and synthesis of anticonvulsive agents as gamma-vinyl GABA-based potential dual acting prodrugs and their biological activities.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Design; Mice; Pentylenetetrazole; Picrotoxin; Prodrugs; | 2000 |
Synthesis and preliminary anticonvulsant activity evaluation of new 2-thioxo-4,5-imidazolidinedione derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Imidazoles; Mice; Pentylenetetrazole; Seizures | 1999 |
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Clonazepam; Evoked Po | 2000 |
Long-term theophylline treatment changes the effects of angiotensin II and adenosinergic agents on the seizure threshold.
Topics: Adenosine; Angiotensin II; Animals; Convulsants; Differential Threshold; Male; Mice; Mice, Inbred IC | 2000 |
Effect of shitei-to, a traditional Chinese medicine formulation, on pentylenetetrazol-induced kindling in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drugs, Chinese Herbal; Kindling, Neur | 2000 |
Antipentylenetetrazol action of clobazam in developing rats.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Clobazam; Convul | 1999 |
The possible role of endogenous glutathione as an anticonvulsant in mice.
Topics: Animals; Brain; Buthionine Sulfoximine; Convulsants; Disease Susceptibility; Drug Synergism; Glutath | 2000 |
Delayed and blunted induction of mRNA for tissue plasminogen activator in the brain of old rats following pentylenetetrazole-induced seizure activity.
Topics: Aging; Analysis of Variance; Animals; Blotting, Northern; Brain; Enzyme Induction; Female; Gene Expr | 2000 |
Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice.
Topics: Animals; Dose-Response Relationship, Drug; Histamine Antagonists; Male; Methylhistamines; Mice; Pent | 2000 |
Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA(A)-system.
Topics: Animals; Anticonvulsants; Barbiturates; Brazil; Diazepam; Flumazenil; GABA Modulators; Hexanes; Hypn | 2000 |
Effects of ammonia on pentylenetetrazole-induced seizure threshold.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Drug Interactions; gamma-A | 1999 |
GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Cerebral Ventricles; Cocaine; Convulsants; Dopamine Up | 1999 |
The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; | 2000 |
[Pharmacological reminder of the emotional condition facilitates the amnestic memory trace retrieval].
Topics: Animals; Avoidance Learning; Conditioning, Classical; Convulsants; Haloperidol; Male; Memory; Pentyl | 2000 |
Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; G | 2000 |
An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.
Topics: Animals; Barbital; Behavior, Animal; Convulsants; Electroshock; Exploratory Behavior; Female; Hypnot | 2000 |
TS+OCD-like neuropotentiated mice are supersensitive to seizure induction.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Humans; Limbic System; Male; Mice; Mice, Inbred BA | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Model | 2000 |
Ureylene anticonvulsants and related compounds.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Male; Mice; Models, Molecular; Pentylenetetrazo | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy | 2000 |
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 2000 |
GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.
Topics: Acoustic Stimulation; Anesthesia; Animals; Anisoles; Anticonvulsants; Carbazoles; Chromatography, Hi | 2000 |
Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures.
Topics: Animals; Arginine; Brain; Convulsants; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Epil | 2000 |
Acute upregulation of blood-brain barrier glucose transporter activity in seizures.
Topics: 1-Butanol; Acute Disease; Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Carbon Radioisotopes | 2000 |
[The neuromediator mechanisms of the action of korazol].
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Pentylenetetrazo | 2000 |
Low-temperature crystal structures of tetrakis-mu-3,5-diisopropylsalicylatobis-dimethylformamidodico pper(II) and tetrakis-mu-3,5-diisopropylsalicylatobis-diethyletheratodicopp er(II) and their role in modulating polymorphonuclear leukocyte activity in ov
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Crystallization; Crystallography, | 2000 |
Anticonvulsant effect of water extract of Scutellariae radix in mice.
Topics: Animals; Anticonvulsants; Binding Sites; Cerebral Cortex; Chlordiazepoxide; Convulsants; Electroshoc | 2000 |
4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzaldehydes; Brain; Convulsants; gamma-Ami | 2000 |
Does fucose or piracetam modify the effect of hypoxia preconditioning against pentylenetetrazol-induced seizures?
Topics: Animals; Fucose; Hypoxia; Male; Neuroprotective Agents; Pentylenetetrazole; Piracetam; Rats; Rats, W | 2000 |
Infusion of 3alpha,5alpha-THP to the pontine reticular formation attenuates PTZ-induced seizures.
Topics: Animals; Convulsants; Diestrus; Female; Male; Ovariectomy; Pentylenetetrazole; Pregnanolone; Proestr | 2000 |
Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation.
Topics: Animals; Cerebral Cortex; Cortical Synchronization; Disease Models, Animal; Electric Stimulation The | 2000 |
Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cocaine; Convulsants; Diazepam; Dopamine Upt | 2000 |
Progesterone and testosterone modulate the convulsant actions of pentylenetetrazol and strychnine in mice.
Topics: Animals; Convulsants; Diestrus; Female; Gonadal Steroid Hormones; Male; Mice; Orchiectomy; Pentylene | 2000 |
Two different anticonvulsant actions of tiagabine in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Respons | 2000 |
Anticonvulsant activity of essential oils and active principles from chemotypes of Lippia alba (Mill.) N.E. Brown.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Female; Injection | 2000 |
Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system.
Topics: Amygdala; Animals; Dentate Gyrus; Electric Stimulation; Electrodes, Implanted; Epilepsy; Evoked Pote | 2000 |
Chemical kindling and seizure susceptibility in morphine dependent rats.
Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Ago | 2000 |
Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones.
Topics: Acoustic Stimulation; Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2000 |
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; | 2000 |
Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms.
Topics: Analgesia; Animals; Atropine; Convulsants; Disease Models, Animal; Injections, Intraperitoneal; Keta | 2001 |
Antiepileptogenic properties of phenobarbital: behavior and neurochemical analysis.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid A | 2000 |
Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol--induced seizures.
Topics: Animals; Brain; Convulsants; Enzymes; Female; Kindling, Neurologic; Pentylenetetrazole; Rats; Rats, | 2001 |
Reduced seizure threshold and hippocampal cell loss in rats exposed to alcohol during the brain growth spurt.
Topics: Age Factors; Animals; Animals, Newborn; Cell Count; Central Nervous System Depressants; Convulsants; | 2001 |
Anticonvulsant properties of N-salicyloyltryptamine in mice.
Topics: Animals; Anticonvulsants; Convulsants; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Penty | 2001 |
PTZ-induced seizures in rats: effects of age and strain.
Topics: Aging; Animals; Brain; Convulsants; Epilepsy, Tonic-Clonic; Male; Pentylenetetrazole; Rats; Rats, Wi | 2001 |
Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation.
Topics: Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Hippocampus; Male; Neuropeptide Y; Pentylenetet | 2001 |
Acute exposure to trichloroethylene differentially alters the susceptibility to chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Disulfiram; Dose-Response Relationship, Drug; Drug | 2001 |
Sex differences in sensitivity to seizures elicited by pentylenetetrazol in mice.
Topics: Animals; Brain; Convulsants; Dose-Response Relationship, Drug; Female; Male; Mice; Pentylenetetrazol | 2001 |
Experiments in the rat pentylenetetrazole infusion threshold model of the ketogenic diet.
Topics: Age Factors; Animals; Convulsants; Dietary Carbohydrates; Dietary Proteins; Disease Models, Animal; | 2001 |
Studies on psychopharmacological activity of Andrographis paniculata extract.
Topics: Acetic Acid; Animals; Behavior, Animal; Magnoliopsida; Mice; Pain; Pain Measurement; Pentylenetetraz | 2001 |
Destruction of peripheral C-fibers does not alter subsequent vagus nerve stimulation-induced seizure suppression in rats.
Topics: Animals; Animals, Newborn; Capsaicin; Electric Stimulation Therapy; Humans; Nerve Degeneration; Nerv | 2001 |
Amino acid derivatives with anticonvulsant activity.
Topics: Amino Acids; Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Chromatography, High | 2001 |
Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae).
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Electroshock; Male; Medicine, Traditional; | 2001 |
Differential effects of NMDA antagonists microinjections into the nucleus reticularis pontis caudalis on seizures induced by pentylenetetrazol in the rat.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizo | 2001 |
Spatiotemporal analysis of Fos expression associated with cocaine- and PTZ-induced seizures in prenatally cocaine-treated rats.
Topics: Animals; Brain; Cell Count; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitat | 2001 |
Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Ataxia; Behavior, Animal; Convulsants; Discrimination | 2001 |
Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V.
Topics: Amino Acid Sequence; Animals; Artificial Gene Fusion; Cell Differentiation; Cell Line; Cerebellum; C | 2001 |
Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsants; Bacteria; Crystallography, X | 2001 |
Characterization of alpha-casozepine, a tryptic peptide from bovine alpha(s1)-casein with benzodiazepine-like activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding Sites; Caseins; Cat | 2001 |
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2001 |
Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-2 Receptor Agonists | 2001 |
Synthesis and evaluation of anticonvulsant activities of some new arylhexahydropyrimidine-2,4-diones.
Topics: Alkanes; Animals; Anticonvulsants; Electroshock; Magnetic Resonance Spectroscopy; Male; Mice; Pentyl | 2001 |
Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures.
Topics: Amlodipine; Animals; Anticonvulsants; Avoidance Learning; Calcium Channel Blockers; Convulsants; Dru | 2001 |
Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues.
Topics: Amino Acids; Animals; Anticonvulsants; Catalysis; Crystallography, X-Ray; Cyclization; Drug Design; | 2001 |
Genetic comparison of seizure control by norepinephrine and neuropeptide Y.
Topics: Animals; Dopamine beta-Hydroxylase; Exercise Test; Flurothyl; Genetic Predisposition to Disease; Han | 2001 |
Vesicular GABA transporter mRNA expression in the dentate gyrus and in mossy fiber synaptosomes.
Topics: Animals; Carrier Proteins; Convulsants; Dentate Gyrus; DNA, Complementary; Electric Stimulation; Ent | 2001 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
Activity-dependent expression of GAD67 in the granule cells of the rat hippocampus.
Topics: Animals; Convulsants; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; In Vitro Technique | 2001 |
Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Brain; Convulsants; Epilepsy; Female; gamma-Aminobut | 2001 |
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Drug Resistance; Electroencepha | 2001 |
Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests.
Topics: Amantadine; Animals; Melatonin; Pentylenetetrazole; Piracetam; Rodentia; Seizures; Valproic Acid | 2001 |
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.
Topics: Adenosine; Angiotensin II; Angiotensin III; Angiotensins; Animals; Brain; Convulsants; Disease Susce | 2001 |
Comparison of the anticonvulsant efficacies and neurotoxic effects of valproic acid, phenytoin, and the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Dietary Fats; Electroencephalography; Energy Intake | 2001 |
Altered brain phosphocreatine and ATP regulation when mitochondrial creatine kinase is absent.
Topics: Acid Anhydride Hydrolases; Adenosine Triphosphate; Animals; Brain; Convulsants; Creatine Kinase; Cre | 2001 |
Behavioural effects of tetrachloroethylene exposure in rats: acute and subchronic studies.
Topics: Animals; Behavior, Animal; Body Weight; Convulsants; Injections, Intravenous; Male; Motor Activity; | 2002 |
Selectivity of the protective effects of dihydropyridine calcium channel antagonists against the ethanol withdrawal syndrome.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Bicuculline; Body Temperature; Calcium Channel B | 2002 |
Neurobehavioural study of subchronic administration of oxydemeton-methyl (insecticide and acaricide) in rats.
Topics: Animals; Antipsychotic Agents; Barbital; Behavior, Animal; Catalepsy; Convulsants; Electroshock; Exp | 2001 |
Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Aspirin; Diazepam; Male; Mice; Pentylenetetrazole; Prostaglandins; Seizure | 2001 |
The additive effect of opioids and nitric oxide in increasing pentylenetetrazole-induced seizure threshold in cholestatic mice.
Topics: Animals; Cholestasis; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Male; M | 2002 |
Seizure-mediated accumulation of the beta subunit of Ca2+/calmodulin-dependent protein kinase II in nuclei of mouse brain cells.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; C | 2002 |
Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug.
Topics: Acoustic Stimulation; Administration, Oral; Amides; Animals; Anticonvulsants; Behavior, Animal; Bicu | 2002 |
Effects of ketoconazole on oestrus cycle and convulsant action of pentylenetetrazol in mice.
Topics: Animals; Antifungal Agents; Convulsants; Estrous Cycle; Female; Injections, Subcutaneous; Ketoconazo | 2001 |
Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Convulsants; Drug Synergism; Male; Mice; Molsidomine; Pentylenetetrazole; | 2002 |
Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Convulsants; Cyclohexanols; Drug Interactions; Ma | 2002 |
Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility.
Topics: 5-alpha Reductase Inhibitors; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Convu | 2002 |
Enhancement of pentylenetetrazole-induced seizures by Shigella dysenteriae in LPS-resistant C3H/HeJ mice: role of the host response.
Topics: Animals; Lipopolysaccharides; Mice; Mice, Inbred C3H; Pentylenetetrazole; Seizures; Shiga Toxin; Shi | 2002 |
The effects of ACTH and adrenocorticosteroids on seizure susceptibility in 15-day-old male rats.
Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Corticosterone; Dehydroepiandrosterone; Desoxycor | 2002 |
Anticonvulsant effects of cyclosporin A on pentylenetetrazole-induced seizure and kindling: modulation by nitricoxidergic system.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclosporine; Dose-Response Relationship, Drug; Enz | 2002 |
Reduced anxiety-- and depression-like behaviors in Emx1 homozygous mutant mice.
Topics: Acoustic Stimulation; Animals; Anxiety; Convulsants; Depression; Exploratory Behavior; Female; Genet | 2002 |
Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2002 |
Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Laurus; Male; Mice; Pentyl | 2002 |
Anticonvulsant activity of aqueous extract of Leonotis leonurus.
Topics: Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dose-Response Relations | 2002 |
The ketogenic diet upregulates expression of the gene encoding the key ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain.
Topics: Acyl Coenzyme A; Acyl-CoA Dehydrogenase; Acyl-CoA Oxidase; Animals; Brain; Coenzyme A Ligases; Convu | 2002 |
The involvement of endogenous opioids and nitricoxidergic pathway in the anticonvulsant effects of foot-shock stress in mice.
Topics: Animals; Convulsants; Differential Threshold; Disease Susceptibility; Electroshock; Endorphins; Foot | 2002 |
Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Creatine Kinase; Creatine Kinase, BB Form; Disease Su | 2002 |
Anticonvulsive activity of Butea monosperma flowers in laboratory animals.
Topics: Animals; Anticonvulsants; Behavior, Animal; Butea; Convulsants; Dyskinesia, Drug-Induced; Electrosho | 2002 |
Nitric oxide (NO) and convulsions induced by pentylenetetrazol.
Topics: Animals; Convulsants; Enzyme Inhibitors; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; | 2002 |
Increase of nucleotidase activities in rat blood serum after a single convulsive injection of pentylenetetrazol.
Topics: Animals; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Nucleotidases; Penty | 2002 |
Studies on the effects of histaminergic agents on seizure susceptibility in mice.
Topics: Animals; Brocresine; Drug Synergism; Histamine; Histamine H1 Antagonists; Histidine; Male; Metiamide | 1976 |
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C | 1976 |
Tolerance and cross-tolerance to the effects of amphetamine isomers on seizure susceptibility.
Topics: Amphetamine; Animals; Dextroamphetamine; Drug Tolerance; Isomerism; Male; Mice; Pentylenetetrazole; | 1977 |
Putative neurotransmitters in CNS and chemoconvulsions.
Topics: Animals; Bemegride; Catecholamines; Central Nervous System; Female; Male; Mice; Neurotransmitter Age | 1977 |
[Inhibitory effects of methyl o-(4-hydroxy-3-methoxycinnamoyl) reserpate (CD-3400) on the central nervous system (author's transl)].
Topics: Agonistic Behavior; Animals; Avoidance Learning; Blepharoptosis; Body Temperature; Cats; Central Ner | 1977 |
Novel anxiolytic agents derived from alpha-amino-alpha-phenyl-o-tolyl-4H-triazoles and -imidazoles.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Crystallography; Hypnotics and Sedatives; Imid | 1978 |
Some central nervous actions of centrophenoxine (Meclofenoxat) in animals.
Topics: Anesthesia; Animals; Antidepressive Agents; Behavior, Animal; Central Nervous System Stimulants; Dru | 1978 |
Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse.
Topics: Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Male; Mice; Neuromuscular Disease | 1979 |
Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain.
Topics: Animals; Anticonvulsants; Brain; Cyclic AMP; Cyclic GMP; Mice; Neurotransmitter Agents; Pentylenetet | 1979 |
A synthetic non-benzodiazepine ligand for benzodiazepine receptors: a probe for investigating neuronal substrates of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Body Temperature; Conflict, Psychological; g | 1979 |
The role of alpha-adrenoceptors in the regulation of pentylenetetrazol convulsions in mice.
Topics: Animals; Clonidine; Hydroxydopamines; Male; Mice; Pentylenetetrazole; Phentolamine; Receptors, Adren | 1979 |
Proceedings: Influence of Metrazol on cortical epileptogenic foci in rats.
Topics: Animals; Electroencephalography; Male; Pentylenetetrazole; Rats; Seizures | 1975 |
Epilepsy and sleep organization in the baboon Papio papio.
Topics: Animals; Papio; Pentylenetetrazole; Photic Stimulation; Seizures; Sleep Stages; Time Factors | 1976 |
Differential effects of cortical speading depression on epileptic foci induced by various convulsants.
Topics: Animals; Cerebral Cortex; Convulsants; Cortical Spreading Depression; Electroencephalography; Male; | 1977 |
Modification of amygdalo-cortical evoked potentials by kindling and pentetrazol-induced generalized convulsions in cats.
Topics: Amygdala; Animals; Cats; Cerebral Cortex; Evoked Potentials; Pentylenetetrazole; Reaction Time; Seiz | 1977 |
Convulsive properties of lindane, lindane metabolites, and the lindane isomer alpha-hexachlorocyclohexane: effects on the convulsive threshold for pentylenetetrazol and the brain content of gamma-aminobutyric acid (GABA) in the mouse.
Topics: Animals; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Mice; Penty | 1978 |
Coupling between neuronal activity and focal blood flow in experimental seizures.
Topics: Animals; Blood-Brain Barrier; Cats; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalogr | 1979 |
Photic and pentylenetetrazol-induced seizure susceptibility in Macaca mulatta.
Topics: Animals; Astrocytoma; Brain Neoplasms; Craniocerebral Trauma; Electroencephalography; Haplorhini; Ma | 1977 |
[Changes in the millivolt potential of brain structures during micropolarization influencing trace phenomena].
Topics: Animals; Brain; Cats; Caudate Nucleus; Electric Stimulation; Electrophysiology; Haplorhini; Hippocam | 1979 |
[Electrophysiologic and morphologic studies of neocortical and deep brain structures during exposure to transcranial micropolarization].
Topics: Animals; Brain; Cats; Cerebral Cortex; Electric Stimulation; Electric Stimulation Therapy; Electroen | 1979 |
Involvement of central cholinoceptors in Metrazol-induced convulsions.
Topics: Animals; Atropine; Female; Male; Mecamylamine; Mice; Neostigmine; Parasympatholytics; Pentylenetetra | 1979 |
Effect of p-chlorophenylalanine on the central nervous excitability threshold and on the activity of some central depressants.
Topics: Animals; Central Nervous System; Depression, Chemical; Fenclonine; Hypnotics and Sedatives; Injectio | 1975 |
[Role of the striatum in the influence of serotoninergic substances on the course of corazole seizures in rats].
Topics: 5-Hydroxytryptophan; Animals; Corpus Striatum; Female; Fenclonine; Male; Pentylenetetrazole; Rats; S | 1976 |
Blockade of the tonic hindlimb extensor component of maximal electroshock and pentylenetetrazol-induced seizures by drugs acting on muscle and muscle spindle systems: a perspective on method.
Topics: Animals; Anticonvulsants; Chlorpromazine; Dantrolene; Electroshock; Gallamine Triethiodide; Hindlimb | 1976 |
The effect of p-bromomethamphetamine (V-111), a selective serotoninergic amphetamine, on the convulsive seizure excitability threshold in mice.
Topics: 5-Hydroxytryptophan; Animals; Fenclonine; Imipramine; Male; Methamphetamine; Mice; Nialamide; Pentyl | 1976 |
Slow- wave sleep and epilepsy: rostral thalamus and basal forebrain lesions suppress spindles and seizures.
Topics: Animals; Cats; Diencephalon; Electroencephalography; Female; Male; Muscle Spindles; Penicillins; Pen | 1977 |
The relationship between magnitude of electroshock stimulation and the effects of digitoxigenin, pentylenetetrazol and brain monoamine reduction on electroshock convulsive thresholds.
Topics: Animals; Biogenic Amines; Brain; Brain Chemistry; Depression, Chemical; Digitoxigenin; Electroshock; | 1977 |
A role for central serotonergic systems in the pattern and intensity of the convulsive response of rats to electroshock.
Topics: Animals; Brain Chemistry; Digitoxigenin; Electroshock; Fenclonine; Male; Methyltyrosines; Pentylenet | 1977 |
Effect of metrazol on cortical epileptogenic foci in rats.
Topics: Animals; Electroencephalography; Male; Penicillins; Pentylenetetrazole; Rats; Seizures | 1978 |
Attempts to produce spike-and-wave complexes in the electrocorticogram of the rat.
Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electrodes, Implanted; Electroencephalogra | 1975 |
Metabolic responses of the awake cerebral cortex to anoxia hypoxia spreading depression and epileptiform activity.
Topics: Animals; Cerebral Cortex; Cortical Spreading Depression; Hypoxia, Brain; Male; NAD; Pentylenetetrazo | 1975 |
On some correlations between adrenergic and serotoninergic mechanisms of convulsive-seizure reactivity.
Topics: Animals; Brain Chemistry; Ditiocarb; Dopamine; Fenclonine; Male; Mice; Norepinephrine; Pentylenetetr | 1975 |
[Increased transmission at electronic synapses and paroxysmal depolarization induced by cardiazol in the Mauthner cell].
Topics: Animals; Goldfish; Membrane Potentials; Neurons; Pentylenetetrazole; Seizures; Synaptic Transmission | 1976 |
Cortical oxygen consumption and NADH flourescence during metrazol seizures in normotensive and hypotensive cats.
Topics: Animals; Blood Pressure; Cats; Cerebral Cortex; Fluorescence; Fluorometry; Hypotension; NAD; Oxygen | 1976 |
[The inhibition of the effects of morphine by synthetic substance P (author's transl)].
Topics: Amphetamine; Animals; Mice; Morphine; Naloxone; Pentylenetetrazole; Receptors, Opioid; Seizures; Sub | 1976 |
Specific and nonspecific multiple unit activities during the onset of pentylenetetrazol seizures. II. Acute lesions interrupting nonspecific system connections.
Topics: Animals; Brain; Cats; Electroencephalography; Hypothalamus; Male; Mesencephalon; Neural Conduction; | 1976 |
On certain relationships between gamma-aminobutyric acid (GABA) and adrenergic mechanisms in convulsive-seizure reaction.
Topics: Aminobutyrates; Animals; Ditiocarb; Electroshock; gamma-Aminobutyric Acid; Injections, Intraventricu | 1976 |
Prostaglandin E2 and cyclic nucleotides in rat convulsions and tremors.
Topics: Animals; Cerebellum; Cyclic AMP; Cyclic GMP; Male; Pentylenetetrazole; Prostaglandins E; Rats; Seizu | 1976 |
Distribution and regulation of cyclic nucleotide levels in cerebellum, in vivo.
Topics: Amphetamine; Animals; Atropine; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Female; Harmaline; In | 1977 |
Cyclic nucleotides in epileptic brain: effects of pentylenetetrazol on regional cyclic AMP and cyclic GMP levels in vivo.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclic GMP; Ethosuximide; | 1977 |
On certain relationships between gamma-aminobutyric acid (GABA) and dopaminergic agents in pentylenetetrazol convulsions.
Topics: Amantadine; Animals; Apomorphine; Dextroamphetamine; Ditiocarb; Dopamine; Drug Interactions; gamma-A | 1978 |
Anticonvulsant drug actions on in vitro and in vivo levels of cyclic AMP in the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Brain; Carbamazepine; Cerebellum; Cerebral Cortex; Clonazepam; | 1979 |
Effects of ischemia on the removal of extracellular potassium in cat cortex during pentylenetetrazol seizures.
Topics: Animals; Blood Pressure; Brain Ischemia; Cats; Cerebral Cortex; Extracellular Space; NAD; Oxygen; Ox | 1979 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; | 1979 |
Effects of reserpine, propranolol, and aminophylline on seizure activity and CNS cyclic nucleotides.
Topics: Aminophylline; Animals; Brain; Cyclic AMP; Cyclic GMP; Female; Mice; Pentylenetetrazole; Propranolol | 1979 |
Interaction between local anesthetics and analeptic drugs.
Topics: Anesthetics, Local; Animals; Central Nervous System Stimulants; Doxapram; Drug Interactions; Lidocai | 1975 |
[The dual role of the caudate nucleus in regulating seizures].
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain Mapping; Cats; Caudate Nucleus; Cerebral | 1975 |
[Psychotropic drugs in the clinical picture of epilepsy (review of the literature)].
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbamazepine; C | 1975 |
Substituted thiadiazolines as inhibitors of central nervous system carbonic anhydrase.
Topics: Animals; Behavior, Animal; Brain; Carbonic Anhydrase Inhibitors; Hydrogen-Ion Concentration; In Vitr | 1975 |
Cerebral energy metabolism during experimental status epilepticus.
Topics: Adenine Nucleotides; Animals; Blood Pressure; Brain; Creatine Kinase; Electroencephalography; Electr | 1975 |
Substantia nigra and pentylenetetrazol threshold in rats: correlation with striatal dopamine metabolism.
Topics: Animals; Cobalt; Corpus Striatum; Dopamine; Levodopa; Male; Neural Pathways; Pentylenetetrazole; Rat | 1979 |
Changes in seizure susceptibility after intracerebral treatment with 5,7-dihydroxytryptamine: role of serotonergic neurons.
Topics: 5,7-Dihydroxytryptamine; Acetazolamide; Animals; Anticonvulsants; Dihydroxytryptamines; Electroshock | 1978 |
Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures.
Topics: Animals; Benzodiazepines; Brain; Inosine; Male; Mice; Pentylenetetrazole; Receptors, Drug; Seizures; | 1979 |
Regulation of the state of phosphorylation of specific neuronal proteins in mouse brain by in vivo administration of anesthetic and convulsant agents.
Topics: Anesthetics; Animals; Brain; Brain Chemistry; Convulsants; Male; Mice; Nerve Tissue Proteins; Pentob | 1979 |
Antagonism of metrazol-induced convulsions by sodium bromide in Rana pipiens.
Topics: Animals; Anura; Bromides; Dose-Response Relationship, Drug; Pentylenetetrazole; Rana pipiens; Seizur | 1977 |
On some relationships between dopaminergic and serotoninergic mechanisms in pentylenetetrazol convulsions in albino mice.
Topics: 5-Hydroxytryptophan; Amantadine; Amphetamine; Animals; Apomorphine; Dopamine; Levodopa; Male; Mice; | 1979 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug | 1977 |
The effects of chronic administration and withdrawal of (+)-amphetamine on seizure threshold and endogenous catecholamine concentrations and their rates of biosynthesis in mice.
Topics: Animals; Brain; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Dr | 1977 |
Time course and development of electro-clinical features in relation to pentylenetetrazol thresholds in monkeys with focal seizures.
Topics: Aluminum Hydroxide; Animals; Dose-Response Relationship, Drug; Electroencephalography; Haplorhini; M | 1977 |
Inhibition of pentylenetetrazol-induced convulsions in rats by prostaglandin E1: role of brain monoamines.
Topics: Animals; Biogenic Amines; Brain Chemistry; Female; Male; Pentylenetetrazole; Prostaglandins E; Rats; | 1978 |
Further studies on the site of action of diazepam: anticonvulsant effect in the rabbit.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Electroenceph | 1979 |
Complex partial and pseudoseizure disorders.
Topics: Adult; Bemegride; Brain; Conversion Disorder; Diagnosis, Differential; Electroencephalography; Epile | 1979 |
Noradrenaline and seizures.
Topics: Animals; Dopamine; Drug Synergism; Hydroxydopamines; Norepinephrine; Pentylenetetrazole; Rats; Seizu | 1979 |
Electroclinical and ultrastructural changes associated with subconvulsant doses of pentylenetetrazol.
Topics: Animals; Brain; Capillaries; Cerebral Cortex; Cerebrovascular Circulation; Dose-Response Relationshi | 1979 |
Effects of intracerebroventricular administration of prostaglandins E1 and E2 on chemically induced convulsions in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Injections, Intraventricular; Isoniazid; | 1979 |
Possible involvement of brainstem norepinephrine in pentylenetetrazol convulsions in rats.
Topics: Animals; Brain Chemistry; Brain Stem; Catecholamines; Hydroxydopamines; Male; Norepinephrine; Pentyl | 1979 |
Effect of tryptophol on pentylenetetrazol and picrotoxin induced convulsion in mice.
Topics: Animals; Anticonvulsants; Brain; Indoles; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoi | 1979 |
Catecholamines and convulsions.
Topics: Animals; Brain; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Electroshock; Hippocampus; Hydr | 1979 |
Central action of new derivatives of tetrahydropirimidinedione-4,6.
Topics: Amphetamine; Analgesics; Animals; Brain; Chloral Hydrate; Drug Synergism; Female; Furans; Hexobarbit | 1979 |
Levels and uptake of taurine in various brain regions after drug-induced generalized convulsions.
Topics: Animals; Brain; Male; Mice; Pentylenetetrazole; Rabbits; Seizures; Species Specificity; Taurine; Tis | 1979 |
Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice.
Topics: Animals; Atropine; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nip | 1979 |
Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex.
Topics: Animals; Cats; Cerebral Cortex; Decerebrate State; Electric Stimulation; Female; gamma-Aminobutyric | 1979 |
Specific and nonspecific multiple unit activities during the onset of pentylenetetrazol seizures. III. Animals with ablations of the cerebral cortex.
Topics: Animals; Brain Stem; Cats; Cerebral Cortex; Cerebral Decortication; Electroencephalography; Evoked P | 1979 |
Effects of gamma-acetylenic GABA and gamma-vinyl GABA on metrazol-activated, and kindled seizures.
Topics: Alkynes; Aminocaproates; Animals; Arousal; Drug Interactions; Electric Stimulation; Electroencephalo | 1979 |
Potentiation of pentylenetetrazole and electroshock induced seizures by prostaglandin F2 alpha.
Topics: Animals; Drug Synergism; Electroshock; Indomethacin; Male; Mice; Mice, Inbred ICR; Pentylenetetrazol | 1979 |
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Pic | 1979 |
Role of dopaminergic and noradrenergic mechanisms in Metrazole convulsions in mice.
Topics: Animals; Apomorphine; Benserazide; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Clonidine; | 1979 |
[Modifications of the synaptosomal level of gamma-aminobutyric acid during convulsions provoked by pentamethylenetetrazol (author's transl)].
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Pentylenetetrazole; Rats; Se | 1979 |
Seizure susceptibility & convulsibility in neonate chicks.
Topics: Aging; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Male; Penicillins; Penty | 1979 |
Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia.
Topics: Animals; Carbon Monoxide Poisoning; Electric Stimulation; Hemoglobins; Hippocampus; Male; Pentylenet | 1979 |
Effect of lysine vasopressin on pentylenetetrazol-induced retrograde amnesia in rats.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Humans; Lypressin; Male; Memory; Pentylen | 1977 |
Pentylenetetrazol: inhibitory avoidance behavior, brain seizure activity, and [3H]lysine incorporation into brain proteins of different mouse strains.
Topics: Amnesia; Animals; Avoidance Learning; Brain; Cerebral Cortex; Electroencephalography; Hippocampus; H | 1977 |
Effect of barbiturate withdrawal on pentylenetetrazol seizure threshold.
Topics: Animals; Barbiturates; Cerebral Cortex; Electroencephalography; Evoked Potentials; Humans; Male; Pen | 1977 |
Effect of alpha-methyl-p-tyrosine on the incidence of spontaneous convulsions observed following barbital withdrawal.
Topics: Animals; Barbital; Barbiturates; Brain Chemistry; Dopamine; Humans; Male; Methyltyrosines; Norepinep | 1978 |
Glutamic acid and ethanol dependence.
Topics: Alcoholism; Animals; Brain Chemistry; Ethanol; Excitatory Amino Acid Antagonists; Glutamates; Humans | 1978 |
Effects of change in dietary folic acid content on pentylenetetrazol seizure threshold in rat.
Topics: Animals; Body Weight; Brain; Differential Threshold; Electroencephalography; Female; Folic Acid; Fol | 1977 |
Comparison of effects of bicuculline, strychnine, and picrotoxin with those of pentylenetetrazol on photically evoked afterdischarges.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Light | 1977 |
The effects of d-amphetamine and temperature on p-cresol and pentylenetetrazol induced convulsions.
Topics: Animals; Body Weight; Cresols; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship | 1977 |
Effect of four convulsants on the time course of presynaptic inhibition and the relation to seizure activity.
Topics: Animals; Bemegride; Bicuculline; Cerebral Cortex; Convulsants; Instinct; Male; Medulla Oblongata; Ne | 1977 |
The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats.
Topics: Animals; Benzodiazepines; Clonazepam; Diazepam; Drug Evaluation, Preclinical; Ethosuximide; Female; | 1977 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric | 1977 |
On some relationships between gamma-aminobutyric acid (GABA) and the cholinergic mechanisms in pentylenetetrazol convulsions.
Topics: Aminobutyrates; Animals; Arecoline; gamma-Aminobutyric Acid; Male; Mice; Parasympathetic Nervous Sys | 1977 |
Correlations between EEG and multiple unit activity of cortifugal axons at the onset of drug induced seizures in cats.
Topics: Action Potentials; Animals; Axons; Cats; Cerebral Cortex; Dieldrin; Electroencephalography; Male; Pe | 1978 |
Antiextensor effects of 3,3-diphenyl-n-propylamine in the mouse.
Topics: Animals; Barbital; Behavior, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity | 1978 |
Role of tissue hypoxia in local regulation of cerebral microcirculation.
Topics: Animals; Arterioles; Carbon Dioxide; Cats; Cerebrospinal Fluid; Cerebrovascular Circulation; Female; | 1978 |
Forebrain noradrenaline and Metrazol-induced seizures.
Topics: Animals; Brain; Dopamine; Hydroxydopamines; Male; Norepinephrine; Pentylenetetrazole; Rats; Seizures | 1978 |
Effect of insulin-induced epileptic seizures on neutral glycolipids of rabbit cerebral cortex.
Topics: Animals; Cerebral Cortex; Glycolipids; Insulin; Neuroglia; Neurons; Pentylenetetrazole; Rabbits; Sei | 1978 |
Anticonvulsant effects of benzhydryl piperazines on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzhydryl Compounds; Male; Mice; Pentylenetetrazole; Pi | 1978 |
A model for the rapid induction of barbiturate tolerance.
Topics: Animals; Barbital; Barbiturates; Brain; Drug Tolerance; Lethal Dose 50; Mice; Pentobarbital; Pentyle | 1978 |
[Carbon dioxide gas provoking and stopping an epileptic seizure].
Topics: Animals; Brain; Carbon Dioxide; Chinchilla; Dose-Response Relationship, Drug; Electroencephalography | 1978 |
[Central effects of o-isopropylaminocyclohexylphenoxypropanol (VUL 111) (author's transl)].
Topics: Animals; Anticonvulsants; Cyclohexanes; Male; Mice; Motor Activity; Pentylenetetrazole; Propanolamin | 1978 |
Antiepileptic drug development: II. Anticonvulsant drug screening.
Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Evaluation, | 1978 |
Increase in vivo of unesterified fatty acids, prostaglandin F2 alpha but not thromboxane B2 in rat brain during drug induced convulsions.
Topics: Animals; Brain; Carbachol; Fatty Acids, Nonesterified; Male; Pentylenetetrazole; Prostaglandin Endop | 1978 |
Rapid changes in brain benzodiazepine receptors after experimental seizures.
Topics: Animals; Binding Sites; Brain; Cerebral Cortex; Diazepam; Electroshock; Hypoxia; Kinetics; Male; Pen | 1978 |
Drug contamination of mortars and pestles.
Topics: Animals; Clonazepam; Decontamination; Drug Compounding; Drug Contamination; Male; Mice; Pentylenetet | 1978 |
Elevation of seizure thresholds: a comparison of cerebellar stimulation, phenobarbital, and diphenylhydantoin.
Topics: Animals; Cerebellar Cortex; Cerebral Cortex; Electric Stimulation; Electroencephalography; Male; Pen | 1978 |
Effect of chronic protein malnutrition on experimentally induced seizures in the rat.
Topics: Animals; Brain; Electroshock; Female; Injections, Intraperitoneal; Pentylenetetrazole; Protein Defic | 1978 |
Changes in the convulsion threshold and in the level of brain biogenic amines in rats chronically treated with phenobarbital or diazepam.
Topics: Animals; Biogenic Amines; Brain Chemistry; Diazepam; Dopamine; Drug Synergism; Male; Norepinephrine; | 1978 |
Properties of two derivatives of gamma-aminobutyric acid (GABA) capable of abolishing Cardiazol- and bicuculline-induced convulsions in the rat.
Topics: Animals; Bicuculline; Brain; Chemical Phenomena; Chemistry, Physical; Female; gamma-Aminobutyric Aci | 1978 |
Effects of prior administration of methionine sulfoximine on the thresholds of seizures induced in mice by 3-mercaptopropionic acid or pentylenetetrazol.
Topics: 3-Mercaptopropionic Acid; Animals; Drug Synergism; Glutamate Decarboxylase; Methionine Sulfoximine; | 1978 |
Misonidazole (Ro-07-0582) sensitizes mice to convulsions induced by hyperbaric oxygen or pentylenetetrazol.
Topics: Animals; Drug Synergism; Female; Mice; Misonidazole; Nitroimidazoles; Oxygen; Pentylenetetrazole; Se | 1978 |
Glutamate-gamma-aminobutyric acid metabolism in cerebral cortex of rat in leptazol-induced convulsions.
Topics: Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamine; M | 1978 |
[Transport of amino acids in rat cerebral regions after experimental convulsions. I. In-vitro studies].
Topics: Amino Acids; Animals; Brain; In Vitro Techniques; Male; Pentylenetetrazole; Rats; Seizures | 1978 |
[Transport of amino acids in rat cerebral regions after experimental convulsions. II. In-vivo studies].
Topics: Amino Acids; Animals; Brain; Male; Pentylenetetrazole; Rats; Seizures | 1978 |
On certain effects of dopaminergic agents in pentylenetetrazol convulsions.
Topics: Amantadine; Animals; Benserazide; Dextroamphetamine; Dopamine; Drug Interactions; Haloperidol; Levod | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; | 1976 |
Effect of sodium cyanate on the seizures susceptibility of mice.
Topics: Animals; Cyanates; Drug Synergism; Electroshock; Lethal Dose 50; Male; Meclofenoxate; Mice; Oxygen; | 1976 |
Effects of edetate on seizure suppressing actions of taurine and GABA.
Topics: Aminobutyrates; Animals; Anticonvulsants; Calcium; Dose-Response Relationship, Drug; Edetic Acid; ga | 1975 |
[Suppression of seizures by taurine - effects of edetate on actions of taurine and GABA (author's transl)].
Topics: Aminobutyrates; Animals; Anticonvulsants; Edetic Acid; GABA Antagonists; gamma-Aminobutyric Acid; Ma | 1975 |
Pentylenetetrazol-induced amnesia: a case for overt seizures.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Humans; | 1976 |
Inhibition of reflex epilepsy by (+/-)-N-n-propylnorapomorphine.
Topics: Animals; Anticonvulsants; Apomorphine; Female; Haplorhini; Male; Mice; Papio; Pentylenetetrazole; Ph | 1976 |
Sulfolane-induced convulsions in rodents.
Topics: Administration, Oral; Animals; Cyclic S-Oxides; Dogs; Drug Interactions; Guinea Pigs; Haplorhini; In | 1976 |
Experimental observations on the effect of amphepramone on the behavior, locomotion, pentretrazol seizures and electroencephalogram.
Topics: Animals; Behavior, Animal; Diethylpropion; Drug Synergism; Electroencephalography; Female; Humans; M | 1976 |
Brain function in epilepsy: midbrain, medullary, and cerebellar interaction with the rostral forebrain.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cobalt; Disease Models, Animal; Electric Stimulation; E | 1976 |
Catecholaminergic involvement in the effects of amphetamine isomers on seizure susceptibility.
Topics: Amphetamine; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; D | 1977 |
Responses of biosystems to chronic microwave exposure.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Brain; Chlorpromazine; Circadian Rhythm; Conditioning, Clas | 1977 |
Convulsant-induced enhancement of non-primary sensory evoked responses in reticular formation pathways.
Topics: Afferent Pathways; Animals; Auditory Cortex; Auditory Perception; Cats; Electroencephalography; Evok | 1977 |
Potential long-acting anticonvulsants. 1; Synthesis and activity of succinimides containing an alkylating group at the 2 position.
Topics: Animals; Anticonvulsants; Electroshock; Male; Methods; Mice; Pentylenetetrazole; Seizures; Succinimi | 1977 |
Acute and chronic effects of (-)-amphetamine on seizure threshold and brain catecholamines in mice.
Topics: Amphetamines; Animals; Brain; Dopamine; Male; Mice; Norepinephrine; Pentylenetetrazole; Seizures | 1977 |
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release.
Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Blood Pressure; Cerebral Cortex; Convulsants; | 1977 |
EEG and extracelluar K+ in rat brain during pentylenetetrazol seizures and during respiratory arrest.
Topics: Animals; Apnea; Brain; Electroencephalography; Extracellular Space; Male; Pentylenetetrazole; Potass | 1977 |
Controlled demonstration of metrazol kindling.
Topics: Animals; Male; Pentylenetetrazole; Rats; Seizures; Time Factors | 1977 |
N-(4-Acetamidophenyl)-anti-tricyclo [4.2.2.025-] deca-3, 9-diene-7, 8-endodicarboximide (1)--a chemically novel anticonvulsant.
Topics: Animals; Anticonvulsants; Bridged-Ring Compounds; Electroshock; Female; Imides; Mice; Mice, Inbred S | 1977 |
Effect of anticonvulsants on seizures developing in the course of daily administration of pentetrazol to rats.
Topics: Amygdala; Animals; Anticonvulsants; Electric Stimulation; Electrodes, Implanted; Electroencephalogra | 1977 |
Protein transport across cerebral vessels during metrazole-induced convulsions.
Topics: Animals; Arteries; Blood-Brain Barrier; Brain; Capillaries; Cats; Cell Membrane Permeability; Endoth | 1977 |
Cholinergic involvement in cobalt-induced epilepsy in the rat.
Topics: Acetylcholine; Animals; Brain Chemistry; Cerebral Cortex; Cholinesterases; Cobalt; Hemicholinium 3; | 1977 |
A new type of anticonvulsant: 1-aryl-3-oxotetrahydroisoquinolines.
Topics: Animals; Anticonvulsants; Electroshock; Isoquinolines; Lethal Dose 50; Mice; Pentylenetetrazole; Sei | 1977 |
The effect of vitamin C-deficienct diet and leptazol on the regional distribution of brain ascorbic acid in guinea-pigs.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Brain; Female; Guinea Pigs; Male; Pentylenetetrazo | 1976 |
Cerebral permeability phenomena in epilepsy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cell Membrane Permeability; Disease Models, Animal; Extr | 1976 |
Effects of acute cerebellectomy on maximal electroshock seizures and anticonvulsant efficacy of diazepam in the rat.
Topics: Animals; Cerebellum; Diazepam; Electroshock; Male; Pentylenetetrazole; Rats; Seizures | 1976 |
[Effect of striatectomy on the course of corazole seizures in rats].
Topics: Animals; Apomorphine; Chlorpromazine; Corpus Striatum; Electroencephalography; Female; Haloperidol; | 1976 |
The anticonvulsant activity of ketamine agains siezures induced by pentylenetetrazol and mercaptopropionic acid.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Female; Glutamate Decarboxylase; | 1976 |
Antiserum to brain gangliosides produces recurrent epileptiform activity.
Topics: Action Potentials; Animals; Antibodies; Antigen-Antibody Reactions; Brain; Edema; Gangliosides; Infl | 1976 |
Dissociation of alcohol tolerance and dependence.
Topics: Alcoholic Intoxication; Animals; Drug Tolerance; Humans; Hydroxydopamines; Hypothermia; Male; Mice; | 1976 |
Time-dependent performance impairments produced by metrazol: amnesia or nonspecific drug effect?
Topics: Amnesia, Retrograde; Animals; Conditioning, Classical; Drinking Behavior; Humans; Male; Memory; Pent | 1976 |
Changes in regional brain acetylcholine levels during drug-induced convulsions.
Topics: Acetylcholine; Animals; Bicuculline; Brain Chemistry; Male; Pentylenetetrazole; Picrotoxin; Rats; Se | 1976 |
Synthesis of substituted anilino-3-methoxy-4-substituted acetoxy) benzylidenes and their monoamine oxidase inhibitory and anticonvulsant properties.
Topics: Animals; Anticonvulsants; Benzylidene Compounds; Brain; Female; In Vitro Techniques; Male; Mice; Mon | 1976 |
The influence of albumin degradation products on central action of amphetamine and pentetrazol.
Topics: Amphetamine; Animals; Brain; Humans; Male; Motor Activity; Pentylenetetrazole; Rats; Seizures; Serum | 1976 |
Experimental study of the effects of imidazol, papaverine and histamine on convulsive-seizure reactivity.
Topics: Animals; Electric Stimulation; Histamine; Imidazoles; Male; Mice; Papaverine; Pentylenetetrazole; Ra | 1976 |
Behavioral and physiological studies of seizures induced by systemic injection of metrazol in chickens.
Topics: Animals; Behavior, Animal; Body Temperature; Chickens; Electroencephalography; Female; Injections, I | 1976 |
Intracellular potentials of cortical neurons and surface activity: I) During epileptogenic discharges induced by pentylenetetrazole in rats.
Topics: Action Potentials; Animals; Cell Membrane; Cerebral Cortex; Neurons; Parietal Lobe; Pentylenetetrazo | 1976 |
[Characteristics of the function of the higher portions of the central nervous system of rats subjected to acute hypoxia in the antenatal period].
Topics: Acute Disease; Altitude; Animals; Atmosphere Exposure Chambers; Central Nervous System; Conditioning | 1976 |
Effects of amphetamine isomers and CNS catecholaminergic blockers on seizures in mice.
Topics: Amphetamine; Animals; Catecholamines; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, | 1976 |
Antagonism of maximal metrazol seizures in rats and its relevance to an experimental classification of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Ataxia; Drug Evaluation, Preclinical; Female; Pentylenetetrazole; Posture; | 1976 |
[Ultrastructural changes of the rat cerebellum due to pentetrazol and phenobarbital administration--in special references to the changes of synaptic vesicles associated with convulsive seizures (author's transl)].
Topics: Animals; Cerebellum; Male; Pentylenetetrazole; Phenobarbital; Rats; Seizures; Synaptic Vesicles | 1976 |
Analysis of preseizure electrocorticographic changes in rats during hyperbaric oxygenation.
Topics: Animals; Diagnosis, Computer-Assisted; Electroencephalography; Hyperbaric Oxygenation; Male; Oxygen; | 1975 |
Specific and nonspecific multiple unit activities during the onset of pentylentetrazol seizures. I. Intact animals.
Topics: Animals; Cats; Electroencephalography; Male; Mesencephalon; Microelectrodes; Motor Cortex; Neural Co | 1975 |
Failure to evoke ictal discharges by metrazol activation in cats with an experimentally induced mild amygdaloid focus.
Topics: Amygdala; Animals; Cats; Cobalt; Electrodes, Implanted; Electroencephalography; Male; Pentylenetetra | 1975 |
Anticonvulsants. 5. Derivatives of 5-ethyl-5-phenylhydantoin and 5,5-diphenylhydantoin.
Topics: Animals; Anticonvulsants; Depression, Chemical; Electroshock; Hydantoins; Lethal Dose 50; Male; Mice | 1975 |
Increased penetration of horseradish peroxidase across the blood-brain barrier induced by Metrazol seizures.
Topics: Animals; Blood-Brain Barrier; Cats; Pentylenetetrazole; Peroxidases; Plants; Seizures | 1975 |
Blockage of cortical spreading depression by picrotoxin foci of paroxysmal activity.
Topics: Animals; Brain; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Pentylenetet | 1975 |
Biochemorphology of cyclobutanecarbonylureas.
Topics: Animals; Cyclobutanes; Drug Synergism; Female; Hypnotics and Sedatives; Male; Mice; Muscle Relaxants | 1975 |
Anticonvulsant activities of delta-8 and delta-9 tetrahydrocannabinol and uridine.
Topics: Animals; Anticonvulsants; Cannabis; Dronabinol; Electroshock; Male; Mice; Pentylenetetrazole; Phenob | 1975 |
[The influence of ethrane on the electro- and pentylenetetrazol-convulsions in mice (author's transl)].
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Anticonvulsants; Chlorine; Dose-Response Relationship, | 1975 |
Amino acid uptake in vivo by the mouse brain and by various regions of the rabbit brain after drug-induced convulsions.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Blood-Brain Barrier; Bra | 1975 |
Effects of acute and chronic paleocerebellar stimulation on experimental models of epilepsy in the cat: studies with enflurane, pentylenetetrazol, penicillin, and chloralose.
Topics: Acoustic Stimulation; Animals; Cats; Cerebellum; Chloralose; Disease Models, Animal; Electric Stimul | 1975 |
Anticonvulsant activity of N,N'-bis[3-(3-substituted urea)propyl]piperazines.
Topics: Animals; Anticonvulsants; Brain; In Vitro Techniques; Lethal Dose 50; Male; Oxygen Consumption; Pent | 1975 |
The anticonvulsant action of GABA-elevating agents: a re-evaluation.
Topics: Allyl Compounds; Aminobutyrates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Drug Evaluati | 1975 |
Pharmacological actions of some simple analogues of reserpine. II. Anticonvulsant effects.
Topics: Amphetamine; Animals; Anticonvulsants; Electroshock; Male; Mice; Motor Activity; Pentylenetetrazole; | 1975 |
The effect of ergotamine and methysergide on serotonin metabolism in the rat brain.
Topics: Animals; Brain; Brain Chemistry; Drug Synergism; Ergotamine; Kinetics; Male; Methysergide; Pentylene | 1975 |
Synthesis and preliminary pharmacologic studies on 1-(4-pyridyl)- and 6-methoxy-1-(4-pyridyl)-beta-carboline.
Topics: Amphetamines; Analgesics; Animals; Antidepressive Agents; Body Temperature; Carbolines; Indoles; Mal | 1975 |
A model for the rapid development of dispositional and functional tolerance to barbiturates.
Topics: Animals; Barbiturates; Drug Tolerance; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Microsomes, | 1975 |
Chiral 1,4-benzodiazepine. VII. Cyclization rates of 2-(n-alpha-ammoniumacyl)-amino-5-chloro-benzophenones in the chiral 1,4-benzodiazepin-2-ones.
Topics: Aggression; Amino Acids; Animals; Behavior, Animal; Benzodiazepinones; Benzophenones; Cyclization; E | 1975 |
Extracellular potassium shifts accompanying epileptic discharge induced in chicken hyperstriatum by systemic injection of Metrazol.
Topics: Animals; Brain; Chickens; Electroencephalography; Pentylenetetrazole; Potassium; Seizures | 1975 |
The effect of stimulation of subcortical serotonin containing structures on pentylenetetrazol induced convulsions.
Topics: Animals; Brain; Pentylenetetrazole; Rats; Seizures; Serotonin | 1975 |
Generality of the kindling phenomenon: some clinical implications.
Topics: Alcoholism; Animals; Disease Models, Animal; Humans; Male; Pentylenetetrazole; Rats; Seizures; Subst | 1975 |
The role of 5-hydroxytryptamine in the mechanism of action of anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Female; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Serotonin | 1975 |
[A histochemical study of brain tissue in experimental convulsive seizures (componetns of acetylcholine metabolism)].
Topics: Acetylcholine; Acetylcholinesterase; Acoustic Stimulation; Animals; Brain; Brain Chemistry; Calcium; | 1975 |
[The role of the caudate nucleus in the development of convulsive discharges].
Topics: Animals; Caudate Nucleus; Electric Stimulation; Electrophysiology; Male; Motor Cortex; Pentylenetetr | 1975 |
Proceedings: Anticonvulsant properties of a series of new 2, 5-pyrrolidone derivatives.
Topics: Animals; Chemical Phenomena; Chemistry; Electroshock; Mice; Pentylenetetrazole; Pyrrolidinones; Seiz | 1975 |
Effects of unilateral lesion in the midbrain reticular formation on kindled amygdaloid convulsion in cats.
Topics: Amygdala; Animals; Cats; Electric Stimulation; Male; Mesencephalon; Neural Inhibition; Pentylenetetr | 1975 |
In vivo measurement of 32P in the brain of a freely moving rat.
Topics: Animals; Brain; Injections, Intraperitoneal; Injections, Intravenous; Kinetics; Liver; Male; Pentyle | 1975 |
Possible role of gangliosides in epilepsy: effects of epileptic seizures on cerebral gangliosides.
Topics: Allyl Compounds; Animals; Brain; Gangliosides; Glycine; Male; Pentylenetetrazole; Rats; Seizures | 1975 |
Alcohol withdrawal reactions in mouse strains selectively bred for long or short sleep times.
Topics: Animals; Ethanol; Humans; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenotype; Seizures; | 1975 |
Anticonvulsive properties of cinnarizine and flunarizine in rats and mice.
Topics: Animals; Anticonvulsants; Cinnarizine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinica | 1975 |
Metabolism, distribution and anticonvulsant properties of N,N'- dimethoxymethyl-phenobarbital in the rat.
Topics: Animals; Anticonvulsants; Brain; Chromatography, Thin Layer; Electroshock; Liver; Male; Pentylenetet | 1976 |
Central nervous system depressants. 13. s-Triazolo-1,5-benzodiazepin-5-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Depression, Chemical; Male; Mice; Nicotine; Pent | 1976 |
Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs.
Topics: Animals; Anticonvulsants; Cannabis; Chlordiazepoxide; Dronabinol; Electroshock; Male; Mice; Nicotine | 1976 |
[Preconvulsive state and hyperfunction of the striatum (clinico-experimental findings)].
Topics: Adolescent; Adult; Aged; Animals; Apomorphine; Convulsants; Corpus Striatum; Electroencephalography; | 1976 |
Limbic seizures cause pronounced changes in the expression of neurokinin B in the hippocampus of the rat.
Topics: Animals; Hippocampus; Immunohistochemistry; Kainic Acid; Limbic System; Male; Neurokinin B; Nucleic | 1992 |
Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+)MK-801 and voltage-dependent calcium channel blockers.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Dizocilpine Maleate; Dose-Response | 1992 |
Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, | 1992 |
Antimetrazol action of two potential anticonvulsants, CM 40907 and SR 41378, in immature rats.
Topics: Animals; Anticonvulsants; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Male; Pentylenetetra | 1992 |
Regional expression of fos-like immunoreactivity following seizures induced by pentylenetetrazole and maximal electroshock.
Topics: Animals; Brain; Electroshock; Hindlimb; Immunohistochemistry; Pentylenetetrazole; Proto-Oncogene Pro | 1992 |
krox 20 messenger RNA and protein expression in the adult central nervous system.
Topics: Animals; Base Sequence; Blotting, Western; Brain; DNA-Binding Proteins; Early Growth Response Protei | 1992 |
In vivo interactions of pentylenetetrazole with benzodiazepine receptors: lack of direct correlation between benzodiazepine receptor occupancy and convulsant potency of this drug.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Electroencephalography; Flum | 1992 |
Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models.
Topics: Animals; Anticonvulsants; Brain; Cells, Cultured; Electric Stimulation; Male; Mice; Models, Biologic | 1992 |
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds | 1992 |
Quantitative autoradiographic measurements of functional changes induced by generalized seizures in the developing rat brain: central adenosine and benzodiazepine receptors and local cerebral glucose utilization.
Topics: Age Factors; Animals; Autoradiography; Bicuculline; Blood Glucose; Brain; Brain Mapping; Epilepsy, G | 1992 |
Cerebral oxygenation state in chemically-induced seizures in the rat--study by near infrared spectrophotometry.
Topics: Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Electroencephalography; Electron Transp | 1992 |
Intrinsic and drug-induced seizures of adult and developing gerbils.
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Epilepsy; Gerbillinae; Neurotransmitter Ag | 1992 |
Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat.
Topics: Animals; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Kindling, Neurologic | 1992 |
Effects of injection interval on pentylenetetrazol (PTZ) kindled seizures in rats.
Topics: Animals; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Time | 1991 |
Preproenkephalin promoter "cassette" confers brain expression and synaptic regulation in transgenic mice.
Topics: Afferent Pathways; Animals; Base Sequence; Brain; Chloramphenicol O-Acetyltransferase; DNA; Enkephal | 1992 |
Modulation of GABAergic transmission by ethanol.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain Chemistry; Ethanol; Female; Flumazenil; GAB | 1992 |
[Seizure susceptibility in aged rats--pentylenetetrazol-induced seizures and amygdaloid kindling seizures].
Topics: Aging; Amygdala; Animals; Disease Susceptibility; Kindling, Neurologic; Male; Pentylenetetrazole; Ra | 1992 |
Selective antagonism of acute ethanol-induced motor disturbances by centrally administered Ro 15-4513 in mice.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Electrodes, Implanted; Ethanol; | 1992 |
Effects of pentylenetetrazol-induced seizures on dopamine and norepinephrine levels and on glucose utilization in various brain regions of the developing rat.
Topics: Animals; Autoradiography; Brain; Brain Chemistry; Dopamine; Female; Glucose; Male; Norepinephrine; P | 1992 |
Pharmacological profile of novel cyclic analogs of 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Brain; Dose-Response Relationshi | 1992 |
[Increase of seizure threshold and resistance to stress in rats after immunization against fragment of diazepam-binding inhibitor].
Topics: Animals; Diazepam Binding Inhibitor; Immunization; Neuropeptides; Pain Measurement; Pentylenetetrazo | 1992 |
An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. I. Behavioral characterization and determination of lumped constant.
Topics: Aging; Animals; Blood Glucose; Brain; Disease Models, Animal; Female; Glucose; Kinetics; Lactates; M | 1992 |
An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. II. Mapping of brain metabolism using the quantitative [14C]2-deoxyglucose technique.
Topics: Aging; Animals; Autoradiography; Blood Glucose; Brain; Brain Mapping; Carbon Radioisotopes; Deoxyglu | 1992 |
Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraperitoneal; Male; Mice; | 1992 |
The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
Topics: Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; | 1992 |
Regional changes in central nervous system thyrotropin-releasing hormone after pentylenetetrazol-induced seizures in dogs.
Topics: Amygdala; Animals; Dogs; Electroencephalography; Epilepsy, Tonic-Clonic; Frontal Lobe; Infusions, In | 1992 |
High-dose methotrexate does not affect the pharmacodynamics of phenobarbital hypnotic action but decreases the central nervous system (CNS) sensitivity to pentylenetetrazol-induced maximal seizures in rats.
Topics: Animals; Brain Chemistry; Central Nervous System; Chromatography, High Pressure Liquid; Glucose; Hyp | 1992 |
Neural sensitivity to pentylenetetrazol convulsions in inbred and selectively bred mice.
Topics: Animals; Body Weight; Brain; Disease Susceptibility; Dose-Response Relationship, Drug; Environment; | 1992 |
Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization.
Topics: Animals; Cytoplasmic Granules; Electric Stimulation; Evoked Potentials; Hippocampus; Kindling, Neuro | 1992 |
Diminished mephobarbital anticonvulsant action following diphenhydramine pretreatment.
Topics: Animals; Diphenhydramine; Drug Interactions; Female; Mephobarbital; Mice; Pentylenetetrazole; Seizur | 1992 |
Pattern of electroencephalographic activity during light induced seizures in genetic epileptic chicken and brain chimeras.
Topics: Animals; Chick Embryo; Chickens; Chimera; Electroencephalography; Electromyography; Female; Male; Me | 1992 |
The prodynorphin system in the rat hippocampus is differentially influenced by kainic acid and pentetrazole.
Topics: Animals; Autoradiography; Enkephalins; Hippocampus; In Situ Hybridization; In Vitro Techniques; Kain | 1992 |
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
Topics: Animals; Anticonvulsants; Astrocytes; Behavior, Animal; Brain; Carbolines; Cells, Cultured; Convulsa | 1992 |
Pentylenetetrazol-induced seizures in rats: an ontogenetic study.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Injections, Subcutaneous; | 1992 |
Anticonvulsant action of lamotrigine during ontogenesis in rats.
Topics: Aging; Animals; Anticonvulsants; Epilepsy, Tonic-Clonic; Injections, Intraperitoneal; Lamotrigine; M | 1992 |
Novel anticonvulsant action of chronic melatonin in gerbils.
Topics: Animals; Anticonvulsants; Gerbillinae; Male; Melatonin; Organ Size; Pentylenetetrazole; Photoperiod; | 1992 |
Biochemical and immunohistochemical demonstration of a tightly bound form of prostaglandin E2 in the rat brain.
Topics: Animals; Binding Sites; Brain; Indomethacin; Male; Organ Specificity; Pentylenetetrazole; Prostaglan | 1992 |
Anticonvulsant effect of the 7-(p-chlorophenyl)-8-phenoxy-4,5-benzo-3-aza-2-nonem.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Male; Mice; Monobactams; Motor Activit | 1992 |
The comparative effects of propofol, thiopental, and diazepam, administered intravenously, on pentylenetetrazol seizure threshold in the rabbit.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Injections, Intravenous; Male; Pentylenetetraz | 1992 |
Characterization of cholinergic regulation of seizures by the midline thalamus.
Topics: Animals; Female; Neostigmine; Nicotine; Parasympathomimetics; Pentylenetetrazole; Pilocarpine; Rats; | 1992 |
Infusion of bicuculline methiodide into the tectum: model specificity of pro- and anticonvulsant actions.
Topics: Animals; Behavior, Animal; Bicuculline; Electroshock; Male; Microinjections; Models, Neurological; P | 1992 |
Comparative anticonvulsant potency and pharmacokinetics of (+)-and (-)-enantiomers of stiripentol.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Dioxolanes; Dose-Response Relationsh | 1992 |
Synthesis and anticonvulsant activity of some new 4-aryl-4-imidazoline-2-one derivatives.
Topics: Animals; Anticonvulsants; Electroshock; Imidazoles; Magnetic Resonance Spectroscopy; Male; Mice; Pen | 1992 |
Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Drug Tolerance; Electrodes, Im | 1992 |
Anticonvulsant and convulsant effects of organic solvents.
Topics: Acetates; Animals; Anticonvulsants; Convulsants; Electroshock; Epilepsy, Tonic-Clonic; Hexanes; Leth | 1992 |
Tolerance to the anticonvulsant effects of clobazam in mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepino | 1992 |
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentobarbital; | 1992 |
The effect of ontogenetic development on the anticonvulsant activity of midazolam.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Female; Growth; Injections, Intra | 1992 |
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; Dose-Response Rela | 1992 |
Effects of selective toxic lesions of cholinergic neurons of the laterodorsal tegmental nucleus on experimental seizures.
Topics: Animals; Aziridines; Choline; Cholinergic Fibers; Female; Histocytochemistry; NADPH Dehydrogenase; P | 1992 |
The effect of propofol and thiopentone on pentylenetetrazol seizure threshold in the rat.
Topics: Animals; Anticonvulsants; Female; Pentylenetetrazole; Propofol; Rats; Rats, Inbred Strains; Seizures | 1992 |
Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity.
Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; In Vitro Techniques; Kidney; Kynur | 1992 |
Anti-pentylenetetrazol effect of intranigral 2-amino-7-phosphonoheptanoate attenuated by muscimol.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Drug Combinations; Male; Muscimo | 1991 |
Interactions between angiotensin II, diazepam, clonazepam and di-n-propylacetate in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Clonazepam; Diazepam; Drug Interactions; Electric Stimulation; Ionophores; | 1991 |
MK-801 prevents chemical kindling induced by pentylenetetrazol in rats.
Topics: Amino Acids; Animals; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; In | 1991 |
Behavioural effects of angiotensin II in the mouse following MPTP administration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Angiotensin II; Animals; Avoidance Learning; Behavior, | 1991 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cort | 1991 |
Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Electroshock; Felbamate; GABA-A | 1991 |
An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol.
Topics: Amino Acids; Amino Acids, Neutral; Analgesics; Animals; Anticonvulsants; Body Temperature; Cannabidi | 1991 |
Importance of histamine for seizure susceptibility.
Topics: Animals; Brain; Brocresine; Dimethindene; Histamine; Histamine Antagonists; Histamine H1 Antagonists | 1991 |
Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice.
Topics: Animals; Cerebral Ventricles; Dipeptides; Glutamates; Glutamic Acid; Injections, Intraventricular; K | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; | 1990 |
Decrease in the function of the gamma-aminobutyric acid-coupled chloride channel produced by the repeated administration of pentylenetetrazol to rats.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlori | 1990 |
The investigation of antiepileptic action of qingyangshen (QYS)--effect of QYS on the concentrations of neuropeptides in rat brain.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Drugs, Chinese Herbal; Male; Neuropeptides; Pentylen | 1991 |
[Corazol kindling in rats with different tolerance to hypoxia].
Topics: Animals; Hypoxia; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Seizures; Time Factors | 1991 |
[Antiepileptic effects of nifedipine].
Topics: Animals; Anticonvulsants; Cerebral Cortex; Epilepsies, Partial; Kindling, Neurologic; Male; Nifedipi | 1991 |
Inhibitory effects of powerline-frequency (60-Hz) magnetic fields on pentylenetetrazol-induced seizures and mortality in rats.
Topics: Animals; Electromagnetic Fields; Lethal Dose 50; Male; Pentylenetetrazole; Rats; Seizures | 1991 |
A comparison of the anticonvulsant effects of propofol and thiopentone against pentylenetetrazol-induced convulsions in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Propofol; Rats; Rats, Inbred St | 1991 |
Effect of tyrosine on the potentiation by aspartame and phenylalanine of metrazol-induced convulsions in rats.
Topics: Animals; Aspartame; Brain; Drug Interactions; Male; Pentylenetetrazole; Phenylalanine; Rats; Rats, I | 1991 |
[Parenteral magnesium sulfate exerts no central anticonvulsant action].
Topics: Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; Electroencephalography; Female; Magnesium | 1991 |
(4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Anticonvulsants; Fa | 1991 |
Changes in seizure latency correlate with alterations in A1 adenosine receptor binding during daily repeated pentylentetrazol-induced convulsions in different mouse brain areas.
Topics: Adenosine; Animals; Brain; Female; Mice; Mice, Inbred BALB C; Pentylenetetrazole; Reaction Time; Rec | 1991 |
MK-801 prevents the decrease in 35S-TBPS binding in the rat cerebral cortex induced by pentylenetetrazol kindling.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convul | 1991 |
Neurobehavioral study of the effect of beta-myrcene on rodents.
Topics: Acyclic Monoterpenes; Animals; Avoidance Learning; Behavior, Animal; Central Nervous System; Male; M | 1991 |
[Drug-induced seizures in taurine-deficient mice].
Topics: Amino Acids; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR | 1991 |
Some new N-substituted alpha-aryl/alkyl succinimides as possible anticonvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Female; Lethal Dose 50; Male; Mice; Monoamine Oxidase In | 1991 |
Pattern of NADPH-diaphorase active neurons in rat forebrain is unchanged after pentylenetetrazol kindling.
Topics: Animals; Histocytochemistry; Kindling, Neurologic; Male; NADPH Dehydrogenase; Neurons; Pentylenetetr | 1991 |
Effects of cold-restraint and swim stress on convulsions induced by pentylenetetrazol and electroshock: influence of naloxone pretreatment.
Topics: Analgesia; Animals; Cold Temperature; Electroshock; Male; Mice; Naloxone; Pain Measurement; Pentylen | 1991 |
Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors.
Topics: Animals; Azides; Benzodiazepines; Carbolines; GABA Antagonists; Isoniazid; Kindling, Neurologic; Mal | 1991 |
Formation of GABOB from 2-hydroxyputrescine and its anticonvulsant effect.
Topics: 4-Aminobutyrate Transaminase; Amine Oxidase (Copper-Containing); Amino Acids; Animals; Anticonvulsan | 1991 |
[Korazol-induced kindling in animals with different sensitivities to the epileptogen].
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Kindling, Neurologic; Male; Pentylenetetr | 1991 |
Effect of phenobarbital on motor seizures elicited by picrotoxin and bicuculline in rats.
Topics: Animals; Bicuculline; Male; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strain | 1991 |
Effect of triazolam in convulsions induced by pentylenetetrazol.
Topics: Animals; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Triazolam | 1991 |
The effect of pain on pentylenetetrazol induced seizures.
Topics: Animals; Formaldehyde; Male; Pain; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; g | 1991 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. II. The effects of MK-801.
Topics: Aging; Amino Acids; Animals; Dizocilpine Maleate; Epilepsies, Myoclonic; Male; Pentylenetetrazole; P | 1991 |
Relative hypoperfusion in rat cerebral cortex during recurrent seizures.
Topics: Animals; Blood Pressure; Cerebral Cortex; Electroencephalography; Electron Transport Complex IV; Mal | 1991 |
[Pharmacologic modulation of central noradrenergic mechanisms and the effect of selected substances on chemically induced seizures: pentylenetetrazole-seizure test (mice)].
Topics: Animals; Anticonvulsants; Male; Mice; Norepinephrine; Pentylenetetrazole; Seizures; Sympathetic Nerv | 1991 |
[Pharmacologic modulation of central noradrenergic mechanisms and the effect of selected substances on chemically induced seizures: maximal pentylenetetrazole-seizure test (mice)].
Topics: Animals; Anticonvulsants; Male; Mice; Norepinephrine; Pentylenetetrazole; Seizures; Sympathetic Nerv | 1991 |
[Pharmacologic modulation of central noradrenergic mechanisms and the effect of selected substances on the anticonvulsant effect of phenobarbital in the maximal pentylenetetrazole-seizure test (mice)].
Topics: Animals; Anticonvulsants; Drug Synergism; Male; Mice; Norepinephrine; Pentylenetetrazole; Phenobarbi | 1991 |
[The effect of propranolol on seizure development in pentylenetetrazole-kindling in the rat].
Topics: Animals; Male; Pentylenetetrazole; Propranolol; Rats; Rats, Inbred Strains; Seizures | 1991 |
[Emotional behavioral disturbances in rats administered subconvulsive doses of korazol].
Topics: Affective Symptoms; Animals; Brain; Dose-Response Relationship, Drug; Electroencephalography; Male; | 1991 |
[The convulsive activity of white rats after immunization with a conjugate of sidnofen and serum albumin].
Topics: Animals; Antidepressive Agents; Immunization; Male; Pentylenetetrazole; Rats; Seizures; Serum Albumi | 1991 |
Convulsive thresholds in mice during the recovery phase from anaesthesia induced by propofol, thiopentone, methohexitone and etomidate.
Topics: Anesthesia, Intravenous; Animals; Anticonvulsants; Azides; Behavior, Animal; Benzodiazepines; Etomid | 1991 |
Selective protection by adenosine receptor agonists against DMCM-induced seizures.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Female | 1991 |
Changes in convulsion susceptibility of lidocaine by alteration of brain catecholaminergic functions.
Topics: Animals; Brain Chemistry; Catecholamines; Lidocaine; Male; Mice; Mice, Inbred Strains; Neurons; Pent | 1991 |
[The anticonvulsant action of (+)- and (-)-tranylcypromine].
Topics: Animals; Anticonvulsants; Electroshock; Mice; Pentylenetetrazole; Postural Balance; Seizures; Stereo | 1991 |
[The action of piracetam, meclofenoxate and vinpocetine in comparative disease models in mice].
Topics: Animals; Anticonvulsants; Electroshock; Meclofenoxate; Mice; Pentylenetetrazole; Piracetam; Postural | 1991 |
The proconvulsive activity of quinolone antibiotics in an animal model.
Topics: Animals; Anti-Infective Agents; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inb | 1991 |
Correlation between enhancement of [3H]flunitrazepam binding and suppression of pentylenetetrazol-induced seizures by L-lysine.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Flunitrazepam; Lysine; Male; Membranes; Mice; Pent | 1991 |
On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic
Topics: Animals; Anticonvulsants; Drug Design; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Femal | 1991 |
The role of the laterodorsal tegmental nucleus of the rat in experimental seizures.
Topics: Alcian Blue; Animals; Baclofen; Bicuculline; Female; Histocytochemistry; In Vitro Techniques; Microi | 1991 |
Differential changes in tachykinins in the rat brain after drug-induced seizures.
Topics: Animals; Brain; Kainic Acid; Kindling, Neurologic; Male; Neuropeptides; Organ Specificity; Pentylene | 1991 |
Synthesis and anticonvulsant activity of 3-alkoxycarbonylaminomethylcarbonylamino-4-benzoylpyridines .
Topics: Animals; Anticonvulsants; Binding, Competitive; Biotransformation; Brain; Electroshock; Flunitrazepa | 1990 |
The effects of the diterpene sclareol glycol on seizures do not depend on central benzodiazepine receptors.
Topics: Animals; Diterpenes; Flumazenil; Hippocampus; In Vitro Techniques; Male; Mice; Pentylenetetrazole; R | 1990 |
[Involvements of neuropeptides in pentylenetetrazol-induced convulsion in rats and effects of TRH and ceruletide on the convulsion].
Topics: Animals; Brain; Ceruletide; Injections, Intraventricular; Male; Neuropeptides; Neurotensin; Pentylen | 1990 |
Synthesis and pharmacological evaluation of 6,8-diaryl 1,2,4-triazolo [4,3,-b] and 1,2,3,4,-tetrazolo [1,5-b] pyridazines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azoles; Behavior, Animal; Bicuculline; Chemical Pheno | 1990 |
Effect of anticonvulsant treatment on kainic acid-induced increases in peptide levels.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Dibenzocycloheptenes; Dizocilpine Maleate; Glutama | 1990 |
Beta-phenylethylamine (PEA): an endogenous anxiogen? Three series of experimental data.
Topics: Animals; Anti-Anxiety Agents; Arousal; Caffeine; Dose-Response Relationship, Drug; Male; Mice; Mice, | 1990 |
Interspecies and interstrain studies on the increased susceptibility to metrazol-induced convulsions in animals given aspartame.
Topics: Animals; Aspartame; Brain; Drug Synergism; Guinea Pigs; Kinetics; Male; Mice; Mice, Inbred DBA; Pent | 1991 |
Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats.
Topics: Animals; Anticonvulsants; Drug Synergism; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inbred Stra | 1991 |
Effects evoked by pentamethylenetetrazol-induced seizures upon N-acetylaspartate and N-acetylaspartylglutamate levels in different regions of the rat neuraxis.
Topics: Animals; Aspartic Acid; Brain; Brain Stem; Dipeptides; Male; Pentylenetetrazole; Rats; Rats, Inbred | 1991 |
The effect of acute hypertension on blood-brain barrier permeability to albumin during experimentally induced epileptic seizures.
Topics: Acute Disease; Albumins; Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Evans Blue; Fema | 1991 |
Correlation between ethosuximide brain levels measured by high performance liquid chromatography and its antiepileptic potential.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Electrop | 1991 |
[Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis].
Topics: Age Factors; Animals; Animals, Newborn; Atmosphere Exposure Chambers; Disease Models, Animal; Diseas | 1991 |
On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures.
Topics: Animals; Bicuculline; Brain; Dinoprost; Epilepsy; Gerbillinae; Handling, Psychological; Kinetics; Pe | 1991 |
Effect of gamma-crotonolactone in experimental models of generalized absence seizures.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Furans; M | 1991 |
Alterations of A1 adenosine receptors in different mouse brain areas after pentylentetrazol-induced seizures, but not in the epileptic mutant mouse 'tottering'.
Topics: Adenosine; Animals; Brain; Epilepsy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Neurologic Mutants; | 1990 |
Effect of subacute insecticide exposure on body weight, drug responses & electrical convulsions in mice.
Topics: Animals; Body Weight; Chlorpromazine; Drug Interactions; Insecticides; Male; Mice; Mice, Inbred Stra | 1990 |
Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats.
Topics: Administration, Oral; Animals; Dextromethorphan; Female; Pentylenetetrazole; Premedication; Rats; Ra | 1990 |
Effect of alprazolam on pentylenetetrazol convulsions.
Topics: Alprazolam; Animals; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1990 |
Threshold to elicit seizures by picrotoxin is lowered in pentylenetetrazol-kindled mice.
Topics: Animals; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Picrotoxin; Seizure | 1990 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inb | 1990 |
Influence of a new antiepileptic drug ORG 6370 on metrazol-induced seizures in rats during ontogenesis.
Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Convulsants; Male; Pent | 1990 |
NMDA antagonist properties of gamma-L-glutamyl-L-aspartate demonstrated on chemically induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dipeptides; Dose-Response Relationship, Drug; Injections | 1990 |
Anticonvulsant effects of clonazepam on chemically induced convulsions.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Clonazepam; Dose-Response Relations | 1990 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate.
Topics: 2-Amino-5-phosphonovalerate; Aging; Amino Acids; Animals; Anticonvulsants; Male; Motor Activity; Pen | 1990 |
In vivo interaction of a polyamine with the NMDA receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraventricul | 1990 |
Anxiogenic effects of a benzodiazepine receptor partial inverse agonist, RO 19-4603, in a light/dark choice situation.
Topics: Animals; Azepines; Choice Behavior; Drug Interactions; Ethanol; Male; Mice; Motor Activity; Pentylen | 1990 |
Localization of the NGFI-A protein in the rat brain.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Brain Chemistry; Cell Nucleus; DNA-Binding Pro | 1990 |
Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties.
Topics: Animals; Anticonvulsants; Binding, Competitive; Flavonoids; Flunitrazepam; Mass Spectrometry; Mice; | 1990 |
[Effects of extracts of different parts of the brain of kindled animals on seizure activity of recipient rats].
Topics: Animals; Brain Tissue Transplantation; Hippocampus; Kindling, Neurologic; Male; Mesencephalon; Neuro | 1990 |
Effects of vagal stimulation on experimentally induced seizures in rats.
Topics: 3-Mercaptopropionic Acid; Action Potentials; Animals; Electric Stimulation; Electric Stimulation The | 1990 |
Anticonvulsant properties of 3-oxo- and 3-imino-4-substituted 1,2,5-thiadiazolidine 1,1-dioxides.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Male; Mice; Pentylenetetrazol | 1990 |
Diazepam sensitive mice: differential sensitivity to the depressant and anticonvulsant effects of diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Mice; Mice, Inbred Str | 1990 |
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Ethosuximi | 1990 |
Effects of potassium channel openers on pentylenetetrazole-induced seizures in mice.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Cromakalim; Drug Antagonism; Female; Guanidines; Mice; Pentyl | 1990 |
Effects of vinburnine on experimental models of learning and memory impairments.
Topics: Amnesia, Retrograde; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Learning Dis | 1990 |
Effect of calcium channel blockers on experimentally induced seizures in rats.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Electroshock; Female; Male; Pentylenetetrazole; | 1990 |
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. I. The influence of administration vehicles.
Topics: Absorption; Animals; Anticonvulsants; Biological Availability; Carbamazepine; Differential Threshold | 1990 |
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; | 1990 |
Effect of quinine on electroshock and pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Drug Synergism; Electroshock; Male; Mice; Mice, Inbred Strains; Pentylenet | 1990 |
Anticonvulsant properties of propofol and thiopentone: comparison using two tests in laboratory mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electroshock; Mice; Pentylenetetrazole; Propofol; Seizur | 1990 |
Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal.
Topics: Aggression; Animals; Anticonvulsants; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Phen | 1990 |
The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat.
Topics: Animals; Calcium Channel Agonists; Dihydropyridines; Electroencephalography; Injections, Intraventri | 1990 |
Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract.
Topics: Amphetamines; Animals; Apomorphine; Behavior, Animal; Electroshock; Female; India; Male; Pentobarbit | 1990 |
Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Decanoic Acids; Fatty Acids; Lauric Acids; Male; Mice; Myristic Acid; Myri | 1990 |
The effects of perinatal hypoxia on pentylenetetrazol-induced seizures in developing rats.
Topics: Animals; Animals, Newborn; Brain; Hypoxia; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Sei | 1990 |
Daily changes in pentylenetetrazol-induced convulsions and open-field behavior in rats.
Topics: Animals; Arousal; Circadian Rhythm; Exploratory Behavior; Male; Motor Activity; Pentylenetetrazole; | 1990 |
[Synthesis and anticonvulsant action of propranolol derivatives with a tertiary nitrogen atom].
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Male; Mice; Pentylenetetrazol | 1990 |
Determination of neurotransmitter release into the caudate nucleus during convulsions induced by pentylenetetrazole using in vivo differential pulse voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Dopamine; Electroencephalography; Hydroxyi | 1986 |
Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocy | 1987 |
Suppression of pentylenetetrazol-induced seizures by hydralazine associated with 5-hydroxytryptaminergic system in rat brain.
Topics: alpha-Methyltyrosine; Animals; Brain; Fenclonine; Hydralazine; Hydroxyindoleacetic Acid; Male; Methy | 1987 |
Generalized seizures induce c-fos protein(s) in mammalian neurons.
Topics: Animals; Brain; Immunologic Techniques; Mice; Neurons; Pentylenetetrazole; Proto-Oncogene Proteins; | 1987 |
The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Suppression of recurrent generalized tonic-clonic seizure discharges by intraventricular perfusion of a calcium antagonist.
Topics: Animals; Pentylenetetrazole; Rats; Recurrence; Seizures; Verapamil | 1988 |
CNS biochemical and pharmacological effects of the isomers of hexachlorocyclohexane (lindane) in the mouse.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Drug | 1988 |
Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Aspartame fails to facilitate pentylenetetrazol-induced convulsions in CD-1 mice.
Topics: Amino Acids; Animals; Aspartame; Brain Chemistry; Dipeptides; Hydroxyindoleacetic Acid; Male; Mice; | 1989 |
Patterns of convulsive susceptibility in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Female; Flumazenil; Male; Mice; Pentylenetetrazo | 1989 |
Pronounced increases in brain levels of calcitonin gene-related peptide after kainic acid induced seizures.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Glutamate Dec | 1989 |
Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure.
Topics: Animals; Benzodiazepines; DNA-Binding Proteins; Gene Expression Regulation; Male; Mice; Mice, Inbred | 1989 |
Antimetrazol action and plasma levels of valproate in developing rats.
Topics: Aging; Animals; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valpro | 1989 |
Serotonin as a facilitatory neurotransmitter in the anticonvulsant activity of methaqualone.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Fenclonine; | 1989 |
Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Isoniazid; Isoxazoles; Male; Nervous System; Neur | 1989 |
The role of the benzodiazepine receptor in mediating long-lasting anticonvulsant effects and the late-appearing reductions in motor activity and exploration.
Topics: Animals; Anticonvulsants; Exploratory Behavior; Lorazepam; Male; Mice; Motor Activity; Oxazepam; Pen | 1989 |
Thienylpyrazoloquinolines with high affinity to benzodiazepine receptors: continuous shift from inverse agonist to agonist properties depending on the size of the alkyl substituent.
Topics: Animals; Chemical Phenomena; Chemistry; Diazepam; Drug Synergism; Male; Mice; Molecular Structure; P | 1989 |
Effects of ketamine on metrazol-induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Behavior, Animal; Ketamine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Re | 1989 |
Repeated swim stress alters brain benzodiazepine receptors measured in vivo.
Topics: Animals; Brain; Cerebrovascular Circulation; Clonazepam; Flumazenil; Male; Mice; Pentylenetetrazole; | 1989 |
Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Drug Interactions; Ethanol; Male; Pentyle | 1989 |
Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats.
Topics: Animals; Anticonvulsants; Central Nervous System; Chromatography, Gas; Flunitrazepam; Male; Pentylen | 1989 |
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA- | 1989 |
Pentylenetetrazole-induced seizure activity produces an increased release of calcium from endoplasmic reticulum by mediating cyclic AMP-dependent protein phosphorylation in rat cerebral cortex.
Topics: Animals; Calcium; Calcium Radioisotopes; Cerebral Cortex; Cyclic AMP; Electroencephalography; Electr | 1989 |
[Effect of glutamic acid palmitamide or linoleamide on convulsions induced by pentetrazole].
Topics: Animals; Corpus Striatum; Female; Glutamates; Limbic System; Linoleic Acids; Mice; Mice, Inbred BALB | 1989 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpin | 1989 |
Chronic but not acute antidepressant treatment increases pentetrazol-induced convulsions in mice.
Topics: Animals; Antidepressive Agents; Desipramine; Drug Synergism; Imipramine; Male; Mice; Mice, Inbred St | 1989 |
The effect of monoamine depletors on metrazol induced convulsions and brain gamma-aminobutyric acid (GABA) contents in rats.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Female; gamma-Aminobutyric Acid; Male; Pentyle | 1989 |
Effects of the gut-stimulating principle in Croton penduliflorus seed oil on the central nervous system.
Topics: Analgesia; Animals; Arachidonic Acids; Central Nervous System; Croton Oil; Endorphins; Female; Gastr | 1989 |
Stimulus-activated changes in brain tissue temperature in the anesthetized rat.
Topics: Anesthesia; Animals; Body Temperature; Brain; Chloral Hydrate; Electric Stimulation; Electroencephal | 1989 |
Ethosuximide affects both pentylenetetrazole- and kainate-induced clonic seizures but differentiates between tonic-clonic seizures.
Topics: Animals; Anticonvulsants; Ethosuximide; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred St | 1989 |
Dimethyl cathate: synthesis and pharmacological investigation.
Topics: Analgesics; Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Dose-Response Relationship, Dru | 1989 |
Effects of tetrahydroaminoacridine (tacrine) derivatives and physostigmine in convulsions induced by pentylenetetrazol.
Topics: Aminoacridines; Animals; Cholinesterase Inhibitors; Male; Pentylenetetrazole; Physostigmine; Rats; R | 1989 |
Anticonvulsant activity of MK-801 and nimodipine alone and in combination against pentylenetetrazole and strychnine.
Topics: Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Dru | 1989 |
The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Pons; Rats; Rats, | 1989 |
Kinetics of drug action in disease states. XXXIII: Disparate effects of pentylenetetrazol in rats as a function of renal disease model and pharmacologic endpoint.
Topics: Animals; Female; Kidney Diseases; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Uranyl N | 1989 |
Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Models, Biological; Pentylenetetrazole; Phenobarb | 1989 |
[The effect of oxymethacil on the level of membrane-bound calcium in the cerebral cortex under the action of corazol].
Topics: Animals; Anticonvulsants; Calcium; Cats; Cell Membrane; Cerebral Cortex; Chlortetracycline; Convulsa | 1989 |
The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin.
Topics: Animals; Anxiety; Bicuculline; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; G | 1989 |
Injection of benzodiazepines but not GABA or muscimol into pars reticulata substantia nigra suppresses pentylenetetrazol seizures.
Topics: Animals; Benzodiazepines; Flurazepam; gamma-Aminobutyric Acid; Male; Midazolam; Muscimol; Pentylenet | 1989 |
Examination of the potential antiepileptic activity of calcium antagonists with different sites of action.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Electroshock; Endoplasmic Reticulum; Ethosuximid | 1989 |
Effects of the diterpene sclareol glycol on convulsive seizures.
Topics: Animals; Bicuculline; Colforsin; Convulsants; Diterpenes; Drug Synergism; Male; Mice; Pentylenetetra | 1989 |
Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Drug Tolerance; Imidazoles; Injections, Intra | 1989 |
Systemically administered glycine protects against strychnine convulsions, but not the behavioural effects of high pressure, in mice.
Topics: Animals; Atmospheric Pressure; Bicuculline; Dose-Response Relationship, Drug; Glycine; High Pressure | 1989 |
Anticonvulsant profile of an anesthetic steroid.
Topics: Anesthetics; Animals; Anticonvulsants; Electroshock; Male; Pentylenetetrazole; Postural Balance; Pre | 1989 |
Pentylenetetrazol-induced seizures in pigeons and the effects of ethosuximide thereon.
Topics: Animals; Anticonvulsants; Columbidae; Ethosuximide; Pentylenetetrazole; Seizures; Time Factors | 1989 |
Synthesis and anticonvulsant evaluation of 1,2-diphenylethane derivatives, potential metabolites of denzimol.
Topics: Animals; Anticonvulsants; Biotransformation; Chemical Phenomena; Chemistry; Electroshock; Female; Im | 1989 |
Evidence of strain differences in GABA-benzodiazepine coupling.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepa | 1987 |
Role of pulmonary edema in phasic changes of cerebral oxygenation during serial seizures.
Topics: Animals; Bicuculline; Brain; Electron Transport Complex IV; Hemodynamics; Hydrogen-Ion Concentration | 1987 |
The impairment of retention induced by pentylenetetrazol in mice may be mediated by a release of opioid peptides in the brain.
Topics: Animals; Avoidance Learning; Benzomorphans; beta-Endorphin; Brain; Dose-Response Relationship, Drug; | 1987 |
Pentylenetetrazol-induced seizure is not mediated by benzodiazepine receptors in vivo.
Topics: Animals; Electroencephalography; Flumazenil; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Sei | 1987 |
Influence of propranolol on metrazol-induced seizures during ontogenesis in rats.
Topics: Animals; Male; Pentylenetetrazole; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, b | 1987 |
Influence of clonidine on metrazol-induced seizures in young rats.
Topics: Animals; Clonidine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alp | 1987 |
Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures.
Topics: Animals; Biological Transport; Brain; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Lys | 1988 |
Effect of anticonvulsants on pentylenetetrazol-induced power spectrum changes in electroencephalograms in rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cyclic AMP; Electroencephalography; Ethosuximide; Male; P | 1987 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; El | 1985 |
Posthypoxic transmitter release from brain slices and behavioural consequences of hypoxia in rats and mice.
Topics: Animals; Atmospheric Pressure; Behavior, Animal; Brain; Dopamine; Hypoxia; In Vitro Techniques; Mice | 1985 |
Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain before and after pentylenetetrazol-induced convulsion.
Topics: Animals; Brain; Frontal Lobe; Hippocampus; Hypothalamus; Male; Pentylenetetrazole; Rats; Rats, Inbre | 1986 |
Effect of morphine and morphine-like analgesics on susceptibility to seizures in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electroshock; Male; Mice; | 1986 |
Bidirectional modulation of GABA function by beta-carbolines.
Topics: Acoustic Stimulation; Anesthesia, General; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning | 1986 |
Altered neurobiological responses to acute immobilization in social-isolated mice.
Topics: Animals; Apomorphine; Brain; Lysergic Acid Diethylamide; Male; Mice; Neurotransmitter Agents; Pentyl | 1986 |
Study on the anticonvulsant activity of clonidine against pentylenetetrazol-induced seizures in rats: pharmacological evidence of alpha 2-adrenoceptors mediation.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Clonidine; Electroencephalography; Male; Mot | 1986 |
Optimizing the pentetrazol infusion test for seizure threshold measurement.
Topics: Animals; Anticonvulsants; Infusions, Intravenous; Male; Mice; Pentylenetetrazole; Seizures; Time Fac | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relation | 1986 |
Activation of a cranial vasodilator pathway during seizures in rats.
Topics: Animals; Atropine; Bicuculline; Cerebrovascular Circulation; Hexamethonium; Hexamethonium Compounds; | 1986 |
Morphine-like analgesics and convulsive threshold for pentetrazole in dogs.
Topics: Analgesics, Opioid; Animals; Dogs; Female; Male; Morphine; Pentylenetetrazole; Seizures | 1986 |
Effect of pentylenetetrazol-induced convulsions on somatostatin-like immunoreactivity in rat cerebrospinal fluid.
Topics: Animals; Cisterna Magna; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Radioimmunoassa | 1987 |
Effect of inferior olive lesion on seizure threshold in the rat.
Topics: Animals; Bicuculline; Cerebellum; Convulsants; Male; Motor Activity; Neural Pathways; Olivary Nucleu | 1987 |
Interactions between morphine-like analgesics and anticonvulsant drugs.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Electroshock; Mal | 1987 |
Tolerance to the anticonvulsant effect of clorazepate and clonazepam in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Clonazepam; Clorazepate Dipotassium; Drug Tolerance; | 1988 |
The benzodiazepine receptor inverse agonists beta-CCM and RO 15-3505 both reverse the anxiolytic effects of ethanol in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Carboli | 1988 |
Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Feeding Behavior; Flumaz | 1988 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Comp | 1988 |
Alpha 2-antagonistic effect of N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON-954).
Topics: Adrenergic alpha-Antagonists; Animals; Body Temperature; Clonidine; Dopamine Antagonists; Female; Gu | 1988 |
A proconvulsant action of selective alpha 2-adrenoceptor antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Carbolines; Convulsan | 1988 |
Clorazepate, correlation between metabolism and anticonvulsant activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Clorazepate Dipotassium; Half-Life; Male; Mice | 1988 |
CNS stimulation and PGE2 release. III. Pentamethylenetetrazole-induced seizures.
Topics: Animals; Brain; Cats; Dinoprostone; Fatty Acids, Nonesterified; Pentylenetetrazole; Seizures | 1989 |
Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antagonists flunarizine and verapamil.
Topics: Animals; Flunarizine; Guinea Pigs; Hippocampus; In Vitro Techniques; Pentylenetetrazole; Seizures; V | 1989 |
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobuty | 1985 |
[Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity].
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Therapy, Combination; Male; Niacinamide; Pen | 1985 |
Participation of serotonergic mechanisms in the anticonvulsant effect of stress in mice treated with pentylenetetrazol.
Topics: Animals; Cold Temperature; Fenclonine; Male; Methysergide; Mice; Mice, Inbred Strains; Pentylenetetr | 1988 |
Anti-metrazol action of R 57720 during postnatal development in rats.
Topics: Aging; Animals; Anticonvulsants; Imidazoles; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; S | 1988 |
Influence of cinromide on metrazol--induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Anticonvulsants; Cinnamates; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; S | 1988 |
Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism.
Topics: Animals; Dihydroxytryptamines; Dinoprost; Female; Fenclonine; Male; Metergoline; Pentylenetetrazole; | 1987 |
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlordiazepoxide; Drug Resistance; Female; Flunitrazepa | 1985 |
Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat.
Topics: Acetylcholinesterase; Acrylonitrile; Animals; Brain; Brain Chemistry; Cholinesterase Inhibitors; Col | 1985 |
CGS 9896: agonist-antagonist benzodiazepine receptor activity revealed by anxiolytic, anticonvulsant and muscle relaxation assessment in rodents.
Topics: Acoustic Stimulation; Aggression; Agonistic Behavior; Animals; Conditioning, Operant; Diazepam; Dose | 1985 |
Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures.
Topics: 2-Aminoadipic Acid; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Lysine; Male; Mice; Pentylene | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenet | 1985 |
The anticonvulsant actions of two taurine derivatives in genetic and chemically induced seizures.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Indoles; Male; Mice; Pentylenetetrazole; Phthalimide | 1985 |
Involvement of thyrotropin-releasing hormone (TRH) neural system of the brain in pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Brain; Male; Pentylenetetrazole; Rats; Receptors, Cell Surface; Receptors, | 1985 |
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbre | 1986 |
The effects of beta-carboline carboxylic acid ethyl ester and its free acid, administered ICV, on the anticonvulsant activity of diazepam and sodium valproate in the mouse.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Drug Interactions; Female; Mice; Mice, Inbred C3H; | 1986 |
Benzodiazepine-receptor mediated convulsions in infant rats: effects of beta-carbolines.
Topics: Animals; Bicuculline; Carbolines; Convulsants; Flurazepam; Pentylenetetrazole; Rats; Rats, Inbred St | 1986 |
Cerebellar cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Bucladesine; Cerebellum; Diazepam; Dibutyryl Cyclic GMP; Dose-Response Rel | 1986 |
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; C | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; M | 1986 |
Purinergic modulation of the seizure threshold for pentylenetetrazol in the rat.
Topics: 2-Chloroadenosine; Adenosine; Animals; Kinetics; Male; Pentylenetetrazole; Phenylisopropyladenosine; | 1985 |
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; H | 1985 |
Apparent pA2 estimation of benzodiazepine receptor antagonists.
Topics: Animals; Diazepam; Drug Interactions; Female; Flumazenil; Male; Pentylenetetrazole; Pyrazoles; Rats; | 1986 |
Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats.
Topics: Animals; Chlorides; Disease Susceptibility; Female; Kindling, Neurologic; Lithium; Lithium Chloride; | 1986 |
A new thienylpyrazoloquinoline: a potent and orally active inverse agonist to benzodiazepine receptors.
Topics: Administration, Oral; Animals; Anticonvulsants; Indicators and Reagents; Male; Mice; Pentylenetetraz | 1987 |
[Effects of GABA-ergic and glycinergic agents on pentamethylenetetrazole-induced convulsions in rats submitted to repeated injections of reserpine].
Topics: Animals; gamma-Aminobutyric Acid; Glycine; Linoleic Acids; Male; Pentylenetetrazole; Psychotropic Dr | 1986 |
Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists.
Topics: Animals; Anticonvulsants; Carbolines; Male; Mice; Pentylenetetrazole; Protein Binding; Receptors, GA | 1987 |
Mapping patterns of c-fos expression in the central nervous system after seizure.
Topics: Animals; Brain Chemistry; Diazepam; DNA-Binding Proteins; Fluorescent Antibody Technique; Gene Expre | 1987 |
Anticonvulsant properties of phencyclidine and ketamine.
Topics: Animals; Anticonvulsants; Hippocampus; Ketamine; Kindling, Neurologic; Mice; Mice, Inbred ICR; Penty | 1986 |
Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice.
Topics: alpha-Methyltyrosine; Animals; Brain; Catecholamines; Dopamine; Hydroxydopamines; Male; Methyltyrosi | 1986 |
Interruption of the connections of the mammillary bodies protects against generalized pentylenetetrazol seizures in guinea pigs.
Topics: Animals; Female; Guinea Pigs; Hippocampus; Mammillary Bodies; Neural Pathways; Pentylenetetrazole; S | 1987 |
Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Dinoprost; Dinoprostone; Ethosuximide; Female; | 1987 |
[Synergic effect of GABA and glycine in the antagonism of convulsions caused by pentetrazole in rats. Study of glycine valproamide].
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inb | 1986 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotox | 1987 |
Decreased susceptibility to local anesthetics-induced convulsions after paradoxical sleep deprivation.
Topics: Anesthetics, Local; Animals; Bupivacaine; Lidocaine; Male; Mice; Pentylenetetrazole; Seizures; Sleep | 1988 |
Localization and induction of c-fos protein-like immunoreactive material in the nuclei of adult mammalian neurons.
Topics: Animals; Brain; Cell Nucleus; Immunologic Techniques; Pentylenetetrazole; Proto-Oncogene Proteins; P | 1988 |
Effect of meclofenoxate on pentylenetetrazol kindling in albino rats.
Topics: Animals; Glycolates; Kindling, Neurologic; Male; Meclofenoxate; Pentylenetetrazole; Rats; Rats, Inbr | 1987 |
A possible role for spinal noradrenaline in the mechanisms of 6-hydroxydopamine against pentylenetetrazol induced convulsions in rats.
Topics: Animals; Female; Hydroxydopamines; Male; Norepinephrine; Oxidopamine; Pentylenetetrazole; Phenobarbi | 1988 |
Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital.
Topics: Animals; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Electroshock; Female; M | 1988 |
Changes in GABA content of the brain and sensitivity to GABA-antagonists during and after repetitive treatment of rats with diphenilhydantoin.
Topics: Animals; Brain; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; P | 1988 |
Anticonvulsant activity of deaminated analogues of glutamic acid diethyl ester (GDEE).
Topics: Animals; Anticonvulsants; Female; Glutamates; Glutarates; Homocysteine; Mice; Pentylenetetrazole; Se | 1988 |
Damage of hippocampal neurons caused by cobalt focus in the cerebral cortex of rats.
Topics: Animals; Cell Count; Cerebral Cortex; Cobalt; Electroencephalography; Hippocampus; Male; Pentylenete | 1988 |
Seizures and recovery from experimental brain damage.
Topics: Animals; Behavior, Animal; Brain Diseases; Forelimb; Locomotion; Male; Motor Cortex; Pentylenetetraz | 1988 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Con | 1988 |
Differential antiepileptic effects of the organic calcium antagonists verapamil and flunarizine in neurons of organotypic neocortical explants from newborn rats.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Flunarizine; Membrane Potentials; Neurons; Organ Culture | 1988 |
Behavioral effects of acute and chronic administration of caffeine in the rat.
Topics: Aggression; Animals; Behavior, Animal; Caffeine; Drug Administration Schedule; Exploratory Behavior; | 1988 |
The neurotoxicity of phenobarbital and its effect in preventing pentylenetetrazole-induced maximal seizure in aging mice.
Topics: Administration, Oral; Aging; Animals; Drug Tolerance; Female; Injections, Intraperitoneal; Mice; Pen | 1988 |
Suppression of pentylenetetrazol-elicited seizure activity by intraosseous propranolol in pigs.
Topics: Animals; Blood Pressure; Bone and Bones; Dose-Response Relationship, Drug; Electroencephalography; H | 1988 |
[Influence of phosphatidylcholine on the threshold dose of pentylenetetrazol for inducing seizure].
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Female; Gerbillinae; Male; Pentylenetetrazol | 1988 |
Intratectal glutamate suppresses pentylenetetrazole-induced spike-and-wave discharges.
Topics: Animals; Cerebral Cortex; Electric Conductivity; Electroencephalography; Female; Glutamates; Humans; | 1988 |
Anticonvulsant effects of avermectin in DBA/2 mice and rat.
Topics: Animals; Anticonvulsants; Cefazolin; Electroshock; Ivermectin; Male; Mice; Mice, Inbred DBA; Pentyle | 1988 |
Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 4. Amidines.
Topics: Amidines; Animals; Anticonvulsants; Electroshock; Indicators and Reagents; Male; Mice; Mice, Inbred | 1988 |
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Inte | 1988 |
Administration of aspartame potentiates pentylenetetrazole- and fluorothyl-induced seizures in mice.
Topics: Animals; Aspartame; Dipeptides; Dose-Response Relationship, Drug; Drug Synergism; Flurothyl; Male; M | 1988 |
Anticonvulsant activity of carbamazepine and N6-L-phenylisopropyladenosine in rabbits. Relationship to adenosine receptors in central nervous system.
Topics: Adenosine; Animals; Anticonvulsants; Caffeine; Carbamazepine; Central Nervous System; Drug Interacti | 1988 |
Age-dependent decrease in the lethal threshold of pentylenetetrazole in mice.
Topics: Aging; Animals; Brain; Female; Male; Mice; Pentylenetetrazole; Respiratory Insufficiency; Seizures; | 1988 |
A comparison of prodrug esters of nipecotic acid.
Topics: Animals; Anticonvulsants; Bicuculline; Esters; GABA Antagonists; Male; Mice; Nipecotic Acids; Parasy | 1988 |
Animal model for evaluating the convulsive liability of beta-lactam antibiotics.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Binding, Competitive; Cefazolin; Cilastatin; Cilastati | 1988 |
Adaptive changes in the effects of angiotensin II on the convulsive-seizure threshold in cases of altered sensitivity of dopamine receptors.
Topics: Angiotensin II; Animals; Apomorphine; Male; Mice; Pentylenetetrazole; Pimozide; Receptors, Dopamine; | 1988 |
Comparative studies on the central effects of the angiotensin II analogue (Sar1 azaVal3 Ile8) AT II.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Animals; Apomorphine; Biogenic Amines; Brai | 1988 |
Behavioral abnormalities and seizure susceptibility in rat after neonatal anoxia.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Female; Hypoxia, Brain; Locomotion; Male; | 1988 |
Measurement during convulsions of guanidino compound levels in cerebrospinal fluid collected with a catheter inserted into the cisterna magna of rabbits.
Topics: Animals; Arginine; Cisterna Magna; Creatinine; Glycine; Guanidines; Male; Pentylenetetrazole; Rabbit | 1988 |
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Brain; gamma-Am | 1988 |
Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure.
Topics: Animals; Anticonvulsants; Azepines; Brain; Dose-Response Relationship, Drug; Female; Models, Biologi | 1988 |
Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brainstem.
Topics: Aminocaproates; Animals; Brain; Brain Mapping; Brain Stem; Electric Stimulation; Female; Hypothalamu | 1987 |
Does dietary tryptophan play a role in the control of convulsive activity?
Topics: Animals; Diet; Male; Pentylenetetrazole; Random Allocation; Rats; Rats, Inbred Strains; Seizures; Tr | 1987 |
Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues.
Topics: Animals; Chromatography, High Pressure Liquid; Dinoprost; Immune Sera; Male; Pentylenetetrazole; Pro | 1987 |
The ionic mechanism of the pentylenetetrazol convulsions.
Topics: Animals; Cobalt; Electrophysiology; Helix, Snails; Ions; Manganese; Nickel; Pentylenetetrazole; Seiz | 1987 |
Endogenous opioids and post-ictal increase in seizure threshold in Mongolian gerbils.
Topics: Animals; Electric Stimulation; Endorphins; Gerbillinae; Morphine; Naloxone; Naltrexone; Pentylenetet | 1987 |
Effects of flunarizine on Metrazol-induced seizures in developing rats.
Topics: Aging; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Flunarizine; Male; Pentylenetetra | 1987 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diaz | 1986 |
Anterior thalamic mediation of generalized pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Behavior, Animal; Bicuculline; Cerebral Cortex; Electroencephalography; Fem | 1986 |
Anticonvulsant activity of the volatile oil from the fruit of Tetrapleura tetraptera.
Topics: Africa, Western; Animals; Anticonvulsants; Female; Fruit; Male; Mice; Oils, Volatile; Pentylenetetra | 1986 |
Effect of pentylenetetrazol-induced convulsions on the development and expression of limbic kindled seizures.
Topics: Amygdala; Animals; Electric Stimulation; Kindling, Neurologic; Male; Olfactory Bulb; Pentylenetetraz | 1987 |
Differential convulsive susceptibility of high-activity and low-activity selected mice in response to GABA antagonists.
Topics: Animals; Behavior, Animal; Bicuculline; Female; Flurothyl; GABA Antagonists; Male; Mice; Pentylenete | 1987 |
Differential effects of caffeine, picrotoxin, and pentylenetetrazol on hippocampal afterdischarge activity and wet dog shakes.
Topics: Animals; Caffeine; Electroencephalography; Hippocampus; Male; Membrane Potentials; Pentylenetetrazol | 1987 |
Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 3. Guanidines.
Topics: Animals; Chemical Phenomena; Chemistry; Electroshock; Guanidines; Mice; Pentylenetetrazole; Rats; Se | 1987 |
Anticonvulsant activity of some 4-aminophenylacetamides.
Topics: Acetamides; Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Electroshock; Male; M | 1987 |
The anticonvulsive activity and toxicity of diazepam in three different formulations. An experimental study in mice.
Topics: Animals; Diazepam; Emulsions; Injections, Intravenous; Male; Mice; Pentylenetetrazole; Seizures | 1987 |
[Effects of sklareol-glycol on pentylenetetrazole-induced convulsions and its interaction with diazepam].
Topics: Animals; Diazepam; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Pent | 1987 |
Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats.
Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Clonaz | 1987 |
Susceptibility to pentylenetetrazol-induced and audiogenic seizures in rats with selective fimbria-fornix lesions and intrahippocampal septal grafts.
Topics: Acoustic Stimulation; Animals; Body Weight; Female; Hippocampus; Neural Pathways; Pentylenetetrazole | 1987 |
Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol.
Topics: Animals; Dose-Response Relationship, Drug; Female; Kindling, Neurologic; Pentylenetetrazole; Rats; R | 1987 |
Effect of a cholecystokinin antagonist on some effects of diazepam.
Topics: Animals; Cholecystokinin; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Glutamine; Mal | 1987 |
Influence of clonazepam on electrocorticographic changes induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Clonazepam; Electrodes, Implanted; Electroencephalography; Male; Pentylenetetrazole; | 1987 |
PK 11195 antagonism of pyrethroid-induced proconvulsant activity.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Isoquinolines; Male; Nitriles; Pentylenetetr | 1986 |
Tolerance to anti-pentylenetetrazol effects following chronic diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Male; Pentylenet | 1986 |
Age-dependent increase in the threshold for pentylenetetrazole induced maximal seizure in mice.
Topics: Aging; Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Female; Male; Mice; Pentyle | 1986 |
Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
Topics: Action Potentials; Animals; Behavior, Animal; Diazepam; Electroshock; gamma-Aminobutyric Acid; Hippo | 1986 |
Anticonvulsant activity of 2- and 3-aminobenzanilides.
Topics: Anilides; Aniline Compounds; Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; | 1986 |
Modification of electroshock and pentylenetetrazol seizure patterns in rats after precollicular transections.
Topics: Animals; Brain; Brain Mapping; Brain Stem; Electroshock; Male; Pentylenetetrazole; Rats; Rats, Inbre | 1986 |
Calcium channel antagonists decrease the ethanol withdrawal syndrome.
Topics: Animals; Calcium Channel Blockers; Diazepam; Ethanol; Flunarizine; Male; Motor Activity; Nimodipine; | 1986 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; | 1986 |
Intraosseous diazepam suppression of pentylenetetrazol-induced epileptogenic activity in pigs.
Topics: Animals; Blood Pressure; Diazepam; Heart Rate; Injections, Intravenous; Pentylenetetrazole; Seizures | 1987 |
Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures.
Topics: Aminocaproates; Animals; Electroshock; Female; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizu | 1986 |
[Effect of exogenous DNA on convulsive activity].
Topics: Animals; DNA; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy; Helix, Snails; Humans; | 1986 |
Effect of scopolamine on physostigmine potentiated convulsions produced by pentylenetetrazole in rats.
Topics: Animals; Pentylenetetrazole; Physostigmine; Rats; Scopolamine; Seizures | 1986 |
Anticonvulsant properties of spirohydantoins derived from optical isomers of camphor.
Topics: Animals; Anticonvulsants; Camphor; Double-Blind Method; Hydantoins; Male; Mice; Pentylenetetrazole; | 1986 |
Searching for models of Alzheimer's disease: a comparison of four amnestic treatments in two behavioral tasks.
Topics: Acetylcholine; Age Factors; Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Discri | 1985 |
Kinetics of drug action in disease states. XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Half-Life; Infusions, Parenteral; Kinetics | 1985 |
Kinetics of drug action in disease states. XV: Effect of pregnancy on the convulsive activity of pentylenetetrazol in rats.
Topics: Animals; Brain; Female; Kinetics; Male; Pentylenetetrazole; Pregnancy; Pregnancy, Animal; Rats; Rats | 1985 |
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; P | 1985 |
A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Parenteral; Mal | 1985 |
[The hippocampus as the determinant structure generating epileptic activity during korazol kindling].
Topics: Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Dimethyl Sulfoxide; Electroencephalography; Ep | 1985 |
Convulsive thresholds in mice: action of 6-hydroxydopamine and eboracin.
Topics: Acoustic Stimulation; Animals; Differential Threshold; Hydroxydopamines; Indenes; Male; Mice; Mice, | 1985 |
Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Mice; Mice, Inbred C3H; Nordazepam; Oxazepam; P | 1985 |
Differential effect of prostaglandin synthetase inhibitor pretreatment on pentylenetetrazol-induced seizures in rat.
Topics: Acetaminophen; Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Electric Stimulation; Electroen | 1985 |
Role of prostaglandins in pentylene tetrazole induced convulsions in mice.
Topics: Animals; Cyclooxygenase Inhibitors; Mice; Mice, Inbred Strains; Pentylenetetrazole; Prostaglandin An | 1985 |
Seizures and thyrotropin-releasing hormone (TRH) neural system in the rat brain.
Topics: Animals; Brain; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Thyrotropin-Releasin | 1985 |
Cycloheximide analogues as potential anticonvulsants.
Topics: Animals; Chemical Phenomena; Chemistry; Cycloheximide; Drug Evaluation; Electroshock; Mice; Pentylen | 1986 |
[Succinate oxidation by rat brain mitochondria in experimental convulsions].
Topics: Animals; Brain; Male; Mitochondria; Oxidation-Reduction; Pentylenetetrazole; Rats; Rats, Inbred Stra | 1986 |
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 1986 |
Selective central nervous system calcium channel blockers--a new class of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channel Blockers; Central Nervous System; Convulsants | 1986 |
Comparative effects of topical perfusions of pentylenetetrazol in the mesencephalon and cerebral cortex of cats.
Topics: Administration, Topical; Animals; Cats; Cerebral Cortex; Decerebrate State; Electroencephalography; | 1985 |
Comparison of anticonvulsive properties of eboracin and phenytoin in mice.
Topics: Animals; Anticonvulsants; Indenes; Lethal Dose 50; Male; Mice; Myoclonus; Pentylenetetrazole; Phenyt | 1985 |
Effects of betaine on seizures in the rat.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Betaine; Glycine; Injections, Intraperitoneal; Injec | 1985 |
Anticonvulsive properties of newly-synthesized indenoimidazolediones.
Topics: Animals; Anticonvulsants; Behavior, Animal; Imidazoles; Indenes; Mice; Pentylenetetrazole; Seizures | 1985 |
Recrystallization from ether causes unusual changes in the convulsant activity of pentylenetetrazol.
Topics: Animals; Chemical Phenomena; Chemistry; Crystallization; Differential Threshold; Drug Interactions; | 1985 |
Response of rats to seizure stimulus modified by feeding.
Topics: Animals; Eating; Electroshock; Female; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Reflex; | 1985 |
Antiepileptic drugs: detection, quantification, and evaluation.
Topics: Age Factors; Animals; Anticonvulsants; Bicuculline; Brain; Convulsants; Drug Evaluation, Preclinical | 1985 |
The effect of inhibiting brain thromboxane biosynthesis on pentylenetetrazole-induced seizure threshold.
Topics: Animals; Brain; Brain Chemistry; Female; Imidazoles; Indomethacin; Methacrylates; Mice; Pentylenetet | 1985 |
[Analysis of the convulsive electrical activity in the basolateral nucleus of the amygdala].
Topics: Amygdala; Animals; Electrophysiology; Male; Pentylenetetrazole; Rats; Seizures | 1985 |
Circannual rhythm of free fatty acids and diacylglycerols in 5-day-old rat cerebrum during pentylenetetrazol-induced convulsions.
Topics: Animals; Brain; Brain Chemistry; Diglycerides; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; | 1985 |
Anticonvulsant activity of some 4-aminobenzanilides.
Topics: Anilides; Animals; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Male; | 1985 |
Phencyclidine-like effect of cyclazocine on pentylentetrazol-induced seizures in laboratory animals.
Topics: Animals; Anticonvulsants; Cyclazocine; Electrodes, Implanted; Electroencephalography; Female; Humans | 1985 |
Unidirectional interaction between flurothyl seizures and amygdala kindling.
Topics: Amygdala; Animals; Disease Susceptibility; Electric Stimulation; Flurothyl; Kindling, Neurologic; Ma | 1985 |
Central neurotoxicity after exposure to organic lead: susceptibility to seizures.
Topics: Animals; Brain Diseases; Drug Interactions; Limbic System; Male; Organometallic Compounds; Pentylene | 1985 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Ger | 1985 |
A single neonatal pentylenetetrazol or hyperthermia convulsion increases kindling susceptibility in the adult rat.
Topics: Amygdala; Animals; Animals, Newborn; Disease Susceptibility; Hippocampus; Hyperthermia, Induced; Kin | 1985 |
Neurophysiological consequences of acute exposure to methylpyridines.
Topics: Animals; Body Temperature; Evoked Potentials, Auditory; Evoked Potentials, Visual; Female; Lethal Do | 1985 |
Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse.
Topics: Animals; Convulsants; Diazepam; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Penty | 1985 |
Effect of cocaine and pentylenetetrazol on cortical kindling.
Topics: Animals; Cerebral Cortex; Cocaine; Electric Stimulation; Infusions, Parenteral; Kindling, Neurologic | 1985 |
Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Drug Interactions; Female; Imidazoles; Injections, I | 1985 |
Anticonvulsant effect of clonazepam in the dog: development of tolerance and physical dependence.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Clonazepam; Dogs; Drug Tolerance; Electroencephalograph | 1985 |
Pyramidal system activity during a cardiazol attack in the cat.
Topics: Animals; Cats; Motor Cortex; Pentylenetetrazole; Pyramidal Tracts; Seizures | 1970 |
Neurophysiological mechanisms involved in grand mal seizures induced by Metrazol and Megimide.
Topics: Amygdala; Animals; Behavior, Animal; Bemegride; Brain; Cats; Caudate Nucleus; Cerebellum; Cerebral C | 1971 |
Alterations of postsynaptic potentials in periodic variations of seizure excitability.
Topics: Action Potentials; Animals; Cerebral Cortex; Electric Stimulation; Pentylenetetrazole; Periodicity; | 1971 |
Membrane potential and postsynaptic potentials of spinal motoneurones in seizure inhibition by CO2.
Topics: Animals; Carbon Dioxide; Membrane Potentials; Motor Neurons; Pentylenetetrazole; Rats; Seizures; Spi | 1971 |
Influence of the pCO2 on macropotentials and single cell discharges in cortical seizure activity.
Topics: Animals; Carbon Dioxide; Cerebral Cortex; Electroencephalography; Motor Cortex; Neurons; Partial Pre | 1971 |
Methylene diamines with an anticonvulsant action.
Topics: Amines; Animals; Electroshock; Methylamines; Pentylenetetrazole; Polyamines; Primidone; Rabbits; Sei | 1971 |
Red nucleus fast activity and signs of paradoxical sleep appearing during the extinction of experimental seizures.
Topics: Animals; Cats; Cerebellar Cortex; Cerebral Cortex; Electric Stimulation; Electroencephalography; Ele | 1971 |
Mechanism of p-chlorophenylalanine-mediated increase in seizure susceptibility: inhibition by cerebellar ablation.
Topics: Adrenergic Agents; Animals; Brain Chemistry; Cerebellum; Fenclonine; Male; Pentylenetetrazole; Pheny | 1972 |
Effect of alpha-hexachlorocyclohexane on the convulsive activity of pentetrazol (Cardiazol) in the rat.
Topics: Animals; Anticonvulsants; Brain Chemistry; Female; Hexachlorocyclohexane; Kidney; Liver; Muscles; Pe | 1972 |
Generalized penicillin epilepsy in the cat: effects of intracarotid and intravertebral pentylenetetrazol and amobarbital injections.
Topics: Amobarbital; Animals; Brain Stem; Carotid Arteries; Cats; Cerebral Cortex; Disease Models, Animal; E | 1974 |
Role of mono-amines in pentylene tetrazol induced seizure in mice.
Topics: Adrenergic Agents; Amines; Amino Acids; Animals; Brain Chemistry; Male; Mice; Pentylenetetrazole; Se | 1974 |
Comparative convulsant activity of various penicillins after intracerebral injection in mice.
Topics: Ampicillin; Animals; Cephaloridine; Drug Synergism; Hydrogen-Ion Concentration; Injections; Male; Me | 1973 |
Potentiation of leptazol seizures by 6-hydroxydopamine.
Topics: Animals; Brain; Catecholamines; Corpus Striatum; Drug Synergism; Hydroxydopamines; Hypothalamus; Mal | 1973 |
Anticonvulsant effect of 5-ethyl,5-phenyl,2-pyrrolidinone and its possible relationship to gamma-aminobutyric acid-dependent inhibitory mechanisms.
Topics: Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Drug | 1973 |
Letter: Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents.
Topics: Aggression; Animals; Anticonvulsants; Barbiturates; Cannabis; Humans; Male; Mice; Pentylenetetrazole | 1973 |
Effects of convulsant and anticonvulsant drugs on the activity of some enzymes in the rat brain.
Topics: Animals; Anticonvulsants; Brain; Central Nervous System Stimulants; Electron Transport Complex IV; M | 1973 |
Glutamine synthetase activity in cat neocortex during the evolution of an ectosylvian spiking focus activated by pentetrazol.
Topics: Aminobutyrates; Animals; Arginine; Cats; Cerebral Cortex; Electroencephalography; gamma-Glutamyltran | 1970 |
[Change in the activity of a cell-free protein-synthesizing system with different functional states of the central nervous system].
Topics: Anesthesia; Animals; Brain; Cell-Free System; Chlorpromazine; gamma-Aminobutyric Acid; Hexobarbital; | 1972 |
Potentiation of amygdaloid kindling and metrazol-induced seizures by 6-hydroxydopamine in rats.
Topics: Amygdala; Animals; Apomorphine; Atropine; Brain; Central Nervous System Stimulants; Dopamine; Drug S | 1974 |
Pharmacology of the adrenergic mechanism.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Brain; Catecholamines; Cell Nucleus; Central Ne | 1974 |
Pharmacologic studies with triflubazam (ORF 8063): a new psychotherapeutic agent.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Appetite Depressants; Behavi | 1974 |
The synthesis and pharmacology of a novel benzodiazepine derivative, 1-methyl-5-(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one(ID-540).
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Bemegride; Benzodiazepinones; Cats; Chlo | 1974 |
Anticonvulsant activity of some beta-adrenoceptor blocking agents in mice.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Electroshock; Female; Hindlimb; Male; Mice; P | 1974 |
Metabolism of glucose in cerebral cortex of rat in leptazol-induced convulsions and effect of gamma-aminobutyric acid on the same.
Topics: Aminobutyrates; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamine; I | 1974 |
Neuro-pharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class.
Topics: Aggression; Amphetamine; Animals; Anti-Anxiety Agents; Avoidance Learning; Carbamates; Chlordiazepox | 1974 |
[The neurotropic and myotropic properties of fucidin].
Topics: Acetylcholine; Administration, Oral; Animals; Anura; Blood Pressure; Cats; Central Nervous System St | 1974 |
The action of convulsants on neuronal and gross wave activity in the thalamus and in the cortex.
Topics: Animals; Cats; Cerebral Cortex; Injections, Intravenous; Neurons; Pentylenetetrazole; Picrotoxin; Se | 1963 |
Pyramidal tract responses during seizures.
Topics: Animals; Cats; Cerebral Cortex; Electric Stimulation; Electroshock; Pentylenetetrazole; Pyramidal Tr | 1965 |
Relations between EEG phenomena and potentials of single cortical cells. II. Spontaneous and convulsoid activity.
Topics: Animals; Cats; Cerebral Cortex; Dendrites; Electroencephalography; Pentylenetetrazole; Potentiometry | 1966 |
A simple cable for reduction of movement artifact in electroencephalographic recordings.
Topics: Animals; Cats; Electroencephalography; Electrophysiology; Pentylenetetrazole; Seizures | 1967 |
An animal model of light sensitive epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Cerebral Cortex; Chlorpromazine; Diazepam; Elec | 1967 |
Experimental epilepsy induced by cobalt powder in lower brain-stem and thalamic structures.
Topics: Animals; Behavior; Brain Stem; Cats; Cerebral Cortex; Cobalt; Consciousness; Electroencephalography; | 1967 |
Bilateral symmetrical epileptogenic foci in cerebral cortex of the monkey.
Topics: Animals; Cerebral Cortex; Corpus Callosum; Estrogens; Haplorhini; Pentylenetetrazole; Seizures | 1967 |
Electro-clinical pharmacological "focalization" of certain experimental epilepsies; effect of a product related to Gaba.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Electroshock; Mice; Penicillins; Pentylenetetrazole; Pyrr | 1967 |
The significance of the cortex for the travelling phenomenon of brain waves.
Topics: Action Potentials; Animals; Basal Ganglia; Cerebral Cortex; Corpus Callosum; Electric Stimulation; E | 1968 |
Interhemispheric spread of drug-induced electrical cortical activity.
Topics: Animals; Barbiturates; Carotid Arteries; Cats; Cerebral Cortex; Corpus Callosum; Cortical Spreading | 1969 |
Metrazol tolerance in a "normal" volunteer population. Results of a 10-year follow-up.
Topics: Achievement; Drug Tolerance; Follow-Up Studies; Humans; Pentylenetetrazole; Seizures; Surveys and Qu | 1969 |
A polygraphic study of Metrazol seizures in psychotics under general anaesthesia and muscular relaxation.
Topics: Anesthesia, General; Electroencephalography; Electromyography; Humans; Muscles; Pentylenetetrazole; | 1969 |
Changes in the passive EEG during convulsive treatment.
Topics: Adolescent; Adult; Electroconvulsive Therapy; Electroencephalography; Electromyography; Humans; Midd | 1969 |
Effect of brain-stem lesions on metrazol-induced seizures in cats.
Topics: Animals; Brain Stem; Cats; Caudate Nucleus; Cerebral Cortex; Electroencephalography; Hypothalamus; L | 1969 |
Relations between EEG activity and post-synaptic potentials of spinal motoneurones during seizure discharges.
Topics: Animals; Electroencephalography; Membrane Potentials; Motor Neurons; Pentylenetetrazole; Rats; Seizu | 1969 |
Metrazol-valium combination for EEG activation.
Topics: Diazepam; Electroencephalography; Humans; Pentylenetetrazole; Seizures | 1970 |
On the electroencephalogram of man. Fourteenth report.
Topics: Adolescent; Adult; Anesthesia; Attention; Cerebral Cortex; Electrodes; Electroencephalography; Epile | 1969 |
Quantitative investigations on the effect of pentamethylenetetrazol on the supraoptic neurones in rabbit.
Topics: Animals; Cell Count; Female; Hypothalamus; Injections, Intraperitoneal; Neurons; Neurosecretory Syst | 1969 |
Modifications of dorsal root potentials during cortical seizures.
Topics: Animals; Blood Pressure; Body Temperature; Cats; Cerebral Cortex; Electric Stimulation; Electroencep | 1970 |
Connections between EEG activity and post-synaptic potentials of spinal motoneurones during convulsions.
Topics: Animals; Carbon Dioxide; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Evoked Pot | 1970 |
[Pharmacology and toxicology of the anticonvulsant agent clonazepam].
Topics: Animals; Anticonvulsants; Bemegride; Benzazepines; Brain; Cats; Central Nervous System; Chemical Phe | 1973 |
Intracarotid pentylenetetrazol injections in the cat.
Topics: Acute Disease; Animals; Carotid Arteries; Cats; Chronic Disease; Electroencephalography; Epilepsies, | 1974 |
Distribution and biochemical effects of pentylenetetrazol in brains of swine treated with a polychlorinated biphenyl.
Topics: Aminobutyrates; Animals; Body Weight; Brain; Caudate Nucleus; Cerebellum; Chromatography, Gas; Dihyd | 1974 |
[Comparative, morphologic examinations of cardiazol and electroconvulsion in animal experiment].
Topics: Animals; Blood-Brain Barrier; Brain; Brain Damage, Chronic; Cats; Electroshock; Ischemic Attack, Tra | 1973 |
[Cerebrovascular changes during cardizol and strychnine convulsions].
Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Electroencephalography; Ischemic Attack, Trans | 1973 |
[Observations on succinate and lactate dehydrogenase activity following cardiazol convulsions. (A histochemical study with microdensitometrical evaluation)].
Topics: Animals; Brain; Brain Damage, Chronic; Brain Edema; Densitometry; Frontal Lobe; Hippocampus; Hypoxia | 1973 |
Effect of the antimetabolite, 6-aminonicotinamide, on sound-induced seizures in mice.
Topics: Animals; Antimetabolites; Brain Stem; Mice; Niacinamide; Pentylenetetrazole; Seizures; Sound | 1966 |
[Hypoglycemia and the pentetrazole threshold].
Topics: Animals; Brain; Cats; Convulsive Therapy; Pentylenetetrazole; Seizures | 1966 |
[Epileptic attack and cortical neuron population].
Topics: Action Potentials; Animals; Cerebral Cortex; Electric Stimulation; Neurons; Pentylenetetrazole; Rabb | 1968 |
Electrographic and behavioral study of convulsants in the cat.
Topics: 4-Aminobenzoic Acid; Amygdala; Anesthetics, Local; Animals; Behavior, Animal; Brain; Cats; Electroen | 1969 |
[Electroencephalographic characteristics of Down's syndrome. A comparative study of patients with and without paroxysmal epileptiform manifestations].
Topics: Adolescent; Adult; Age Factors; Child; Down Syndrome; Electroencephalography; Female; Humans; Light; | 1969 |
[Neurophysiological study of Ro-05-4023].
Topics: Animals; Behavior, Animal; Blood Pressure; Brain; Cardiovascular System; Cats; Cerebral Cortex; Elec | 1970 |
Seizure susceptibility after manipulation of brain serotonin.
Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Blood-Brain Barrier; Bra | 1970 |
[Effect of a very high frequency electromagnetic radiation on sensitivity to pentetrazol in white mice].
Topics: Animals; Central Nervous System; Injections, Intraperitoneal; Magnetics; Mice; Pentylenetetrazole; R | 1971 |
Alterations in cation levels and Na-K ATPase activity in rat cerebral cortex during the development of cobalt-induced epilepsy.
Topics: Adenosine Triphosphatases; Animals; Calcium; Cerebral Cortex; Cobalt; In Vitro Techniques; Magnesium | 1973 |
Effect of subconvulsant doses of metrazol on the electrographic pattern of the cobalt epileptogenic focus and vigilance.
Topics: Animals; Attention; Cobalt; Electrodes, Implanted; Electroencephalography; Male; Pentylenetetrazole; | 1973 |
Interaction of pentylenetetrazol and trimethadione on the metabolism of serotonin in brain and its relation to the anticonvulsant action of trimethadione.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Brain; Brain Chemistry; Dose-Response Relationship, D | 1974 |
Epileptogenic focus in the frog telencephalon. Seizure irradiation from the focus.
Topics: Animals; Anura; Electroencephalography; Penicillin G; Pentylenetetrazole; Seizures; Telencephalon | 1967 |
[Nicotine and pentetrazol-induced EEG changes in normal and hypothyroid rabbits].
Topics: Animals; Cerebral Cortex; Electroencephalography; Hippocampus; Hypothyroidism; Iodine Isotopes; Meth | 1967 |
The developing animal as a model.
Topics: Age Factors; Animals; Barbiturates; Brain; Central Nervous System; Electric Stimulation; Electroshoc | 1969 |
Relation of dopa and 5-HTP to convulsions induced by strychnine and leptazol.
Topics: 5-Hydroxytryptophan; Animals; Anura; Dihydroxyphenylalanine; Injections, Subcutaneous; Muscle Contra | 1970 |
Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia.
Topics: Animals; Brain; Cell Membrane; Cyclic AMP; Electroshock; Ethyl Ethers; Fatty Acids, Nonesterified; H | 1971 |
Phospholipid labelling by ( 32 P)-orthophosphate and ( 3 H)-myo-inositol in the stimulated goldfish brain in vivo.
Topics: Animals; Brain; Cyprinidae; Electroshock; Inositol; Pentylenetetrazole; Phosphates; Phosphatidylinos | 1972 |
Cerebral pO 2 , pCO 2 and pH: changes during convulsive activity and their significance for spontaneous arrest of seizures.
Topics: Acidosis; Action Potentials; Animals; Carbon Dioxide; Cerebral Cortex; Electric Stimulation; Electro | 1972 |
Studies on kinin-like substances in brain.
Topics: Amobarbital; Animals; Bradykinin; Brain; Brain Chemistry; Brain Stem; Cerebellum; Cerebral Cortex; E | 1973 |
Substituted piperazinoquinazolones: relationship between selective inhibition of nicotinamide adenine dinucleotide-dependent oxidations and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Brain; Citrates; Hydroxybutyrates; In Vitro Techniques; Isocitrates; Ketog | 1974 |
Substituted benzoxazole-benzthiazole-2-thiones: interrelationship between anticonvulsant activity and inhibition of nicotinamide adenine dinucleotide-dependent oxidations and monoamine oxidase.
Topics: Aminobenzoates; Animals; Anticonvulsants; Benzoxazoles; Brain; In Vitro Techniques; Isocitrates; Ket | 1974 |
Differential effects of pentylenetetrazol on REM sleep in naive and cobalt-epileptic rats.
Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electroencephalography; Electromyography; | 1974 |
Synthesis of substituted piperidino carbamides: correlation between CNS effects and selective inhibition of NAD-dependent oxidations.
Topics: Amides; Animals; Anticonvulsants; Brain; Drug Synergism; In Vitro Techniques; Ketoglutaric Acids; Le | 1974 |
Metabolic effects of seizures.
Topics: Acidosis; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bicarbonates; Blood Flow Velocity; | 1974 |
The anticonvulsant activity of triethylcholine in cats.
Topics: Animals; Anticonvulsants; Cats; Choline; Female; Male; Pentylenetetrazole; Phenobarbital; Seizures | 1966 |
Convulsant properties of allylglycine.
Topics: Amino Acids; Animals; Central Nervous System Stimulants; Drug Synergism; Mice; Pentylenetetrazole; S | 1965 |
Pulmonary changes with convulsions induced by drugs and oxygen at high pressure.
Topics: Amino Alcohols; Animals; Central Nervous System Stimulants; Chlorpromazine; Curare; Dibenzylchloreth | 1966 |
Epileptogenic effect on extradural and extracranial cobalt.
Topics: Animals; Brain; Central Nervous System Stimulants; Cobalt; Female; Pentylenetetrazole; Rats; Seizure | 1965 |
Some basic ketones with central nervous system depressant activity.
Topics: Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Brain; Butyrophenones; Catalepsy; Cat | 1966 |
Modification of metrazol induced convulsions in rats by antihistaminics.
Topics: Animals; Diphenhydramine; Histamine H1 Antagonists; Pentylenetetrazole; Pheniramine; Piperazines; Pr | 1966 |
Anticonvulsant and some neuropharmacological properties of 2-methyl-3-omicron-tolyl-6-chloro-4(3h)-quinazolone and related compounds.
Topics: Analgesics; Animals; Anticonvulsants; Behavior, Animal; Body Temperature; Central Nervous System; Dr | 1966 |
Indoklon and metrazol convulsions in epileptic and control monkeys.
Topics: Animals; Brain; Central Nervous System Stimulants; Cerebral Cortex; Electroencephalography; Female; | 1967 |
The effect of (+-)-p-chloroamphetamine on the susceptiblity to seizures and on the monoamine level in brain and heart of mice and rats.
Topics: Amphetamine; Animals; Brain; Brain Chemistry; Dopamine; Fluorometry; Mice; Myocardium; Norepinephrin | 1967 |
The effects of repeated flurothyl-induced seizures on convulsive thresholds and brain monoamines in rats.
Topics: Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Dopamine; Electroshock; Male; My | 1967 |
Increased susceptibility of mice to seizures after some anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Drug Synergism; Electroshock | 1967 |
Effect of pretreatment with monoamine oxidase inhibitors or (+)-amphetamine on leptazol convulsions in mice and rats.
Topics: Amphetamine; Animals; Iproniazid; Male; Mice; Monoamine Oxidase Inhibitors; Nialamide; Pargyline; Pe | 1968 |
Synthesis and pharmacological action of some N-alkyl morpholines and their salts.
Topics: Acetylcholine; Animals; Female; Magnetic Resonance Spectroscopy; Mice; Morpholines; Nicotine; Pain; | 1968 |
[Convulsive and anticonvulsive effects of aliphatic and alicyclic sulfonamides].
Topics: Animals; Anticonvulsants; Blood Glucose; Carbonic Anhydrases; Central Nervous System; Central Nervou | 1968 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; C | 1969 |
Laboratory evaluation of antiepileptic drugs. The use of chronic lesions.
Topics: Animals; Brain Damage, Chronic; Central Nervous System Stimulants; Cerebral Cortex; Ethers; Fluorine | 1969 |
The effect of alkyl substitution in drugs. XX. Some pharmacological investigations into a series of 1-(o-alkylphenyl)-2-methyl and 1-(o-alkylphenyl)-2-ethylcyclohexanols.
Topics: Animals; Blood Pressure; Cats; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Coronary V | 1969 |
The importance of endogenous catecholamines in the activity of some CNS stimulants.
Topics: Amphetamine; Animals; Antidepressive Agents; Catecholamines; Central Nervous System; Ephedrine; Male | 1969 |
An experimental evaluation of the anticonvulsant activity of some antihistaminic drugs.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Female; Histamine H1 Antagoni | 1969 |
[The effects of Bemegride, Pentetrazole and Nikethamide on blood pressure, heart rate and respiration in alcohol-intoxicated rats].
Topics: Alcoholic Intoxication; Animals; Bemegride; Blood Pressure; Central Nervous System Stimulants; Heart | 1970 |
Pharmacology of a nicotinamido-methylaminopyrazolone (Ra 101).
Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Carrageena | 1970 |
[Introduction of mass psychology in animals to pharmacology. 6. Mutural relation in simultaneity convulsion and non-convulsin in E1-mice].
Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Camphor; Central Nervous Sy | 1970 |
Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine.
Topics: Amides; Amino Acids; Animals; Bemegride; Brain; Brain Chemistry; Caffeine; Carbon Isotopes; Central | 1971 |
[Mutal inhibitory effect between chlorpromazine and several convulsants on convulsion].
Topics: Aminobutyrates; Animals; Aspartic Acid; Central Nervous System Stimulants; Chlorpromazine; Dogs; Dru | 1971 |
Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity.
Topics: Adenosine Diphosphate; Animals; Blood Pressure; Cats; Cerebral Cortex; Fluorometry; Hypoxia; Mitocho | 1971 |
Convulsive activity in garter snakes.
Topics: Animals; Behavior, Animal; Bemegride; Body Temperature; Brain; Central Nervous System; Central Nervo | 1972 |
Temporary alteration of cerebrovascular permeability to plasma protein during drug-induced seizures.
Topics: Animals; Autoradiography; Blood Flow Velocity; Blood Pressure; Blood Volume; Blood-Brain Barrier; Br | 1972 |
Investigation on pharmacological properties of hexadiphane, oxazepam hemisuccinate and of their combination.
Topics: Animals; Azepines; Benzene Derivatives; Diphenylacetic Acids; Drug Synergism; Female; Gallbladder; G | 1972 |
Effects of ethanol on serotonin metabolism in brain.
Topics: Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Behavior, Animal; Brain; Ethanol; Hydrox | 1974 |
Failure to obtain "cannabis-directed behavior" and abstinence syndrome in rats chronically treated with cannabis sativa extracts.
Topics: Adrenal Glands; Animals; Barbiturates; Behavior, Animal; Body Weight; Brain; Cannabis; Drinking Beha | 1974 |
Quinazolines and 1,4-benzodiazepines. 69. 1-Vinyl-1,4-benzodiazepin-2-ones and 1-vinylquinazolin-2(1H)-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Chlordiazepoxide; Depression, Chemical; Diazepam | 1974 |
1-(3,4-Dichlorobenzamidomethyl)cyclohexyldimethylamine and related compounds as potential analgesics.
Topics: Administration, Oral; Analgesics; Animals; Behavior, Animal; Benzamides; Body Temperature; Central N | 1974 |
Monoamine oxidase inhibitory and anticonvulsant properties of 1,2,4-trisubstituted 5-imidazolones.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Female; Imidazoles; Male; Mice; Monoamine Oxidase | 1974 |
Cortical seizure patterns in multidimensional view: the information content of equipotential maps.
Topics: Animals; Cerebral Cortex; Computers; Electric Stimulation; Electrodes, Implanted; Electroencephalogr | 1974 |
Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats.
Topics: Amygdala; Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electrodes, | 1974 |
Anticonvulsant and antiinflammatory activity of natural plant coumarins and triterpenoids.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain; Carrageenan; Coumarins; Edema; Female; Hy | 1974 |
Effect of cholinesterase inhibitors on the susceptibility to pentetrazole of the mouse.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; F | 1974 |
[Thresholds of pentetrazol-induced convulsion in young and adult mice (author's transl)].
Topics: Animals; Male; Mice; Pentylenetetrazole; Seizures | 1974 |
Pentylenetetrazol-induced retrograde amnesia and brain seizures in mice.
Topics: Amnesia; Animals; Avoidance Learning; Cerebral Cortex; Dose-Response Relationship, Drug; Electrodes, | 1974 |
The effect of withdrawal from cannabis on pentylenetetrazol convulsive threshold in mice.
Topics: Animals; Body Weight; Cannabis; Dronabinol; Drug Interactions; Drug Tolerance; Ethanol; Humans; Male | 1974 |
Proceedings: The effect of sodium gamma-hydroxybutyrate on the CNS of rats and mice.
Topics: Aggression; Animals; Anticonvulsants; Depression, Chemical; Dose-Response Relationship, Drug; Explor | 1974 |
The pharmacology of fletazepam a centrally-acting muscle relaxant.
Topics: Aggression; Animals; Anticonvulsants; Avoidance Learning; Benzazepines; Benzodiazepines; Cats; Diaze | 1974 |
Central effects of a series of N1-, N4-acyl piperazine derivatives.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Evoked Potentials; Female; Hexobarbital; Humans; Lethal | 1974 |
Inhibition of post-decapitation convulsions by reserpine.
Topics: Animals; Cervical Vertebrae; Cordotomy; Male; Norepinephrine; Pentylenetetrazole; Picrotoxin; Rats; | 1973 |
Epileptogenic properties of cobalt and related metals applied directly to cerebral cortex of rat.
Topics: Animals; Cobalt; Copper; Female; Iron; Male; Manganese Poisoning; Metals; Nickel; Palladium; Pentyle | 1974 |
Brain and serum concentrations of diazepam in experimental epilepsy.
Topics: Acute Disease; Animals; Brain; Cats; Diazepam; Dose-Response Relationship, Drug; Penicillin G; Penty | 1974 |
Synthesis of some N-carboxylic acid derivatives of 3-phenoxypyrrolidines, 4-phenoxypiperidines, and 3-phenoxynortropanes with muscle relaxant and anticonvulsant activities.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Cats; Cordotomy; Dose-Response Relati | 1974 |
Changes in sensitivity to convulsion in mice with olfactory bulb ablation.
Topics: Animals; Cyclohexanes; Electroshock; Limbic System; Male; Mice; Olfactory Bulb; Pentylenetetrazole; | 1972 |
Anticonvulsant effects of uridine: comparative analysis of metrazol and penicillin induced foci.
Topics: Animals; Anticonvulsants; Anura; Autoradiography; Cerebral Cortex; Disease Models, Animal; Electroen | 1973 |
Relationship between CNS depressant activity and selective enzyme inhibition by quinazolone salicylhydrazide derivatives.
Topics: Animals; Anticonvulsants; Brain; Drug Synergism; Electroconvulsive Therapy; Hydrazines; Hypnotics an | 1973 |
A permanent change in convulsive threshold in normal and brain-damaged rats with repeated small doses of pentylenetetrazol.
Topics: Animals; Brain Damage, Chronic; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Pentylenete | 1972 |
The role of prefrontal cortex in grand mal convulsion.
Topics: Adolescent; Adult; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Frontal Lobe; Humans; Mal | 1972 |
Induced seizures as therapy for experimental stroke in monkeys.
Topics: Animals; Carbon Dioxide; Cerebral Arterial Diseases; Cerebrovascular Circulation; Cerebrovascular Di | 1972 |
Para-substituted N-acetyl-L(S)- and -D(R)- -amino-N-phenylsuccinimides and -glutarimides. Substituent effects on stereoselective anticonvulsant activity.
Topics: Acetates; Amino Acids; Animals; Anticonvulsants; Circular Dichroism; Electroshock; Glutarates; Imide | 1972 |
Brain glycogen and serum glucose after convulsions induced by electroshock and pentamethylenetetrazole in rats.
Topics: Animals; Blood Glucose; Electroshock; Female; Glycogen; Pentylenetetrazole; Rats; Seizures | 1972 |
[The acetylcholine system in various sections of the brain according to the stages of repeating convulsive attacks evoked by corazol].
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain Chemistry; Brain Stem; Cerebellum; Cholinesteras | 1972 |
Structure activity relationship of 5 newly synthesized anticonvulsants.
Topics: Animals; Anticonvulsants; Benzimidazoles; Electroshock; Mice; Pentylenetetrazole; Rats; Seizures; St | 1972 |
[Anticonvulsive properties of diarylamidines].
Topics: Administration, Oral; Amidines; Animals; Anticonvulsants; Behavior, Animal; Chemical Phenomena; Chem | 1972 |
Fine structural changes of the rabbit brain in the cardiazol-convulsion.
Topics: Animals; Basal Ganglia; Brain; Caudate Nucleus; Cerebellar Cortex; Hippocampus; Male; Microscopy, El | 1972 |
Resistance to insulin convulsions in fasted mice.
Topics: Animals; Blood Glucose; Fasting; Insulin; Male; Mice; Pentylenetetrazole; Seizures; Strychnine; Time | 1973 |
Anticonvulsant properties of Mannich base derivatives of 2-phenylsuccinimide. 3.
Topics: Alkalies; Animals; Anticonvulsants; Electroshock; Hindlimb; Male; Mice; Pentylenetetrazole; Pyrrolid | 1973 |
Spontaneous release and during metrazol convulsions of 5-hydroxytryptamine in some brain regions of conscious cat.
Topics: Amygdala; Animals; Brain; Cats; Caudate Nucleus; Female; Geniculate Bodies; Hippocampus; Male; Penty | 1973 |
Effect of lithium on acute oxygen toxicity and associated changes in brain gamma-aminobutyric acid.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Hyperbaric Oxygenation; Lithium; Magnesium; Male; M | 1973 |
Acute and chronic effects of d- and 1-amphetamine on seizure susceptibility in mice.
Topics: Amphetamine; Animals; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Tolerance; Electrosh | 1973 |
Anticonvulsants. 3. Phenobarbital and mephobarbital derivatives.
Topics: Animals; Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Electroshock; Hypnotics and S | 1973 |
N-alkylaminocarbazoles as potential anticonvulsant and diuretic agents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbazoles; Central Nervous System; Diuresis; Diuretics; | 1973 |
Metabolism and anticonvulsant properties of primidone in the rat.
Topics: Amides; Animals; Anticonvulsants; Brain Chemistry; Chromatography, Gas; Electroshock; Male; Malonate | 1973 |
A comparison of the anticonvulsant, neurotoxic and lethal effects of diphenylbarbituric acid, phenobarbital and diphenylhydantoin in the mouse.
Topics: Animals; Anticonvulsants; Barbiturates; Dose-Response Relationship, Drug; Electroshock; Lethal Dose | 1973 |
The use of on-line telephonic computer analysis of the E.E.G. in anaesthesia.
Topics: Anesthesia; Anesthesia, Inhalation; Animals; Cerebrovascular Circulation; Communication; Computers; | 1973 |
Central monoamines and convulsine thresholds in mice and rats.
Topics: Amphetamine; Animals; Biogenic Amines; Brain; Dopamine; Electroshock; Female; Hydroxyindoleacetic Ac | 1973 |
The effect of some anticonvulsant drugs on leptazol and bicuculline induced acetylcholine efflux from rat cerebral cortex.
Topics: Acetylcholine; Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Dioxoles; Dose-Response Relatio | 1973 |
Some studies on the convulsant action of folic acid.
Topics: Alkaloids; Animals; Auditory Threshold; Cerebral Ventricles; Dioxoles; Electroshock; Folic Acid; Fol | 1973 |
Neuropharmacology of SQ 10,996, a compound with several therapeutic indications.
Topics: Amides; Animals; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Carbamazepine; C | 1973 |
State-dependent learning produced by Metrazol.
Topics: Amnesia; Animals; Avoidance Learning; Discrimination Learning; Exploratory Behavior; Housing, Animal | 1973 |
Epileptiform activity induced by antiserum to synaptic membrane.
Topics: Animals; Caudate Nucleus; Cerebral Cortex; Corpus Callosum; Electroencephalography; Erythrocytes; Fr | 1973 |
Dependence of anticonvulsant drug action on central monoamines.
Topics: Animals; Anticonvulsants; Dopamine; Drug Interactions; Electroshock; Ethosuximide; Lethal Dose 50; M | 1973 |
Discharges of alpha and gamma fibers to flexor muscles during metrazol-induced seizures in cat.
Topics: Action Potentials; Animals; Blood Pressure; Cats; Electrocardiography; Electroencephalography; Motor | 1973 |
Thresholds for electro- and chemoconvulsions in mice after termination of treatment with phenobarbital.
Topics: Animals; Anticonvulsants; Differential Threshold; Dose-Response Relationship, Drug; Electroshock; Fe | 1973 |
Anticonvulsant effect of 5-ethyl, 5-phenyl, 2-pyrrolidinone and its possible relationship to gamma-aminobutyric acid-dependent inhibitory mechanisms.
Topics: Alkaloids; Aminobutyrates; Animals; Anticonvulsants; Dioxoles; Hydrazones; Isoquinolines; Mice; Moto | 1973 |
Effects of diazepam on dorsal root potentials induced by cortical paroxysmal activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Blood Pressure; Body Temperature; Cats; Cerebral Cor | 1973 |
Pyrazolodiazepines. 1,3-(And 2,3-) dialkyl-4,6-dihydro-8-arylpyrazolo(4,3-e)(1,4)diazepin-5-ones as antianxiety agents.
Topics: Animals; Azepines; Behavior, Animal; Central Nervous System; Drinking Behavior; Mice; Pentylenetetra | 1973 |
1-Polyfluoroalkylbenzodiazepines; 1.
Topics: Animals; Behavior, Animal; Benzazepines; Benzodiazepinones; Central Nervous System; Hydrocarbons, Fl | 1973 |
Anticonvulsants. 4. Metharbital and phenobarbital derivatives.
Topics: Animals; Anticonvulsants; Barbiturates; Electroshock; Lethal Dose 50; Male; Mice; Pentylenetetrazole | 1973 |
Pentylenetetrazol convulsions and brain catecholamine turnover rate in rats and mice receiving diphenylhydantoin or benzodiazepines.
Topics: Animals; Benzazepines; Body Temperature; Brain; Brain Chemistry; Catecholamines; Cerebellum; Chlordi | 1973 |
[An analysis of the mechanism of the neurotropic activity of the cetyl ester of gamma-aminobutyric acid].
Topics: Alcohols; Amines; Aminobutyrates; Animals; Chlorpromazine; Esters; Male; Mice; Pentylenetetrazole; R | 1973 |
Cerebral energy metabolism and the regulation of cerebral blood flow.
Topics: Adenosine Triphosphate; Animals; Brain; Carbon Dioxide; Cerebrovascular Circulation; Disease Models, | 1973 |
[Change of the course of the spasmodic process caused by corazole during administration of adrenaline and aminazin].
Topics: Animals; Brain; Chlorpromazine; Drug Interactions; Epinephrine; Male; Pentylenetetrazole; Rabbits; S | 1973 |
Convulsions elicited by handling: a sensitive method of measuring CNS excitation in mice treated with reserpine or convulsant drugs.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Ethanol; Humans; Male; Mice; Pent | 1973 |
The influence of SKF-525A on the acute pharmacological properties of chlordiazepoxide.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Brain; Chlordiazepoxide; Conflict, Psycho | 1973 |
Changes in the neuro-excitability of alcohol-dependent rats undergoing withdrawal as measured by the pentylenetetrazole seizure threshold.
Topics: Animals; Disease Susceptibility; Ethanol; Humans; Male; Pentylenetetrazole; Proadifen; Rats; Seizure | 1973 |
OI 77, a new tricyclic antidepressant.
Topics: Aggression; Amphetamine; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Cats; Drug Sy | 1973 |
[Proteinase activity of different sections of the brain in corazole-induced convulsions].
Topics: Animals; Brain; Male; Pentylenetetrazole; Peptide Hydrolases; Rats; Seizures; Time Factors | 1973 |
Canine cerebral oxygen consumption during enflurane anesthesia and its modification during induced seizures.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Blood Glucose; Blood Pressure; Brain; Carbon Dioxide; | 1974 |
Effect of seizures and anticonvulsant agents on hippocampal RNA concentration.
Topics: Anesthesia, General; Animals; Anticonvulsants; Cannabis; Cerebral Cortex; Depression, Chemical; Elec | 1974 |
Suppression of seizures by taurine--specific or non-specific?
Topics: Animals; Anticonvulsants; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Taurine | 1974 |
Centrally acting muscle relaxants. Isomeric 9,10-dihydroxy-1,2,3,4,4a,9,10,10a(trans-4a,10a)-octahydrophenanthrenes and their carbamate esters.
Topics: Animals; Carbamates; Electroshock; Male; Mass Spectrometry; Mice; Molecular Conformation; Motor Acti | 1974 |
[Quantitative structure-activity relationships for biologically active sydnones].
Topics: Aminopyrine N-Demethylase; Animals; Blood Pressure; Drug Evaluation, Preclinical; Lethal Dose 50; Mi | 1974 |
Anticonvulsant activity and monoamine oxidase inhibitory properties of 1,3,5-trisubstituted pyrazolines.
Topics: Acetophenones; Animals; Anticonvulsants; Brain; Kynurenine; Male; Mice; Monoamine Oxidase Inhibitors | 1974 |
Anticonvulsant effects of cannabinoids in mice: drug interactions within cannabinoids and cannabinoid interactions with phenytoin.
Topics: Animals; Cannabis; Depression, Chemical; Dose-Response Relationship, Drug; Drug Combinations; Drug I | 1974 |
Proceedings: The relationship of ascorbic acid to leptazol-induced convulsions in guinea-pigs.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Guinea Pigs; Pentylenetetrazole; Seizures | 1974 |
Studies on some aspects of the neuropharmacology of butylurea.
Topics: Administration, Oral; Analgesics; Animals; Anticonvulsants; Barbiturates; Butanes; Central Nervous S | 1974 |
Study on the paroxysmal bioelectrical activity and overt seizure patterns elicited by pentylenetetrazol in the cat.
Topics: Animals; Behavior, Animal; Brain; Cats; Electrophysiology; Female; Male; Myoclonus; Pentylenetetrazo | 1967 |
The effects of intracerebroventricularly administered noradnamine and other sympathomimetic amines upon leptazol convulsions in mice.
Topics: Animals; Cerebral Ventricles; Dibenzocycloheptenes; Dopamine; Injections; Male; Mice; Norepinephrine | 1968 |
Spontaneous cure of limbic system epilepsy in the cat.
Topics: Aluminum; Animals; Behavior, Animal; Cats; Cobalt; Electroencephalography; Limbic System; Pentobarbi | 1968 |
[Bioelectrical findings from various regions of the rat brain after 3-acetylpyridine poisoning].
Topics: Amygdala; Animals; Brain; Caudate Nucleus; Cerebral Cortex; Electrodes; Electroencephalography; Hipp | 1969 |
Effect of Metrazol convulsions on 35S entry into cat central nervous system.
Topics: Animals; Brain; Cats; Ethyl Ethers; Female; Male; Pentylenetetrazole; Seizures; Spinal Cord; Sulfate | 1967 |
Differential behavioural and biochemical effects on the central nervous system by cycloserine isomers.
Topics: Animals; Antidepressive Agents; Brain; Colonic Diseases, Functional; Cycloserine; Electroencephalogr | 1965 |
Clinical results and the significance of Forel-H-tomy in the treatment of epilepsy.
Topics: Animals; Cats; Cerebral Cortex; Cryosurgery; Electroencephalography; Epilepsy, Tonic-Clonic; Follow- | 1966 |
Diazepam as anticonvulsant in epileptic and normal monkeys.
Topics: Animals; Chlordiazepoxide; Diazepam; Electroencephalography; Haplorhini; Injections, Intramuscular; | 1967 |
Symmetrical epileptogenic foci in monkey cerebral cortex. Mechanisms of interaction and regional variations in capacity for synchronous discharges.
Topics: Animals; Brain Mapping; Cats; Cerebral Cortex; Corpus Callosum; Electroencephalography; Frontal Lobe | 1968 |
[Electroencephalographic study of cardiazol convulsion in psychotics during anesthesia and relaxation. Attempt at a neurophysiological analysis and comparison with epileptic convulsion of the grand mal type].
Topics: Anesthesia, General; Convulsive Therapy; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Met | 1968 |
Effect of electroshock and pentamethylenetetrazol on serum cholesterol levels in monkeys.
Topics: Animals; Blood Chemical Analysis; Blood Proteins; Cholesterol; Electroshock; Female; Haplorhini; Hem | 1969 |
[Experimental studies of epileptic reactions. Chronic stimulations of the sensomotor cortex of the cat and the rabbit].
Topics: Adult; Aged; Aluminum; Animals; Cats; Cerebral Cortex; Child; Electrodes; Electroencephalography; Ep | 1968 |
The pharmacology of 2-(ethylamino)-2-(2-thienyl)-cyclohexanone-HCl (CI-634).
Topics: Anesthesia, General; Animals; Blood Pressure; Cardiovascular System; Catalepsy; Cats; Central Nervou | 1969 |
Genetic models of epilepsy with special reference to the syndrome of the Papio papio.
Topics: Age Factors; Animals; Anticonvulsants; Chlorpromazine; Electroencephalography; Ethiopia; Evoked Pote | 1969 |
The hyperexcitable neuron as a model for the laboratory analysis of anticonvulsant drugs.
Topics: Acetazolamide; Action Potentials; Aluminum; Animals; Behavior, Animal; Cats; Cerebral Cortex; Electr | 1969 |
[Cortical recordings by means of microelectrodes in photosensitive Papio papio].
Topics: Animals; Cerebral Cortex; Electroencephalography; Gallamine Triethiodide; Haplorhini; Light; Pentyle | 1968 |
The pharmacology of prazepam. A new benzodiazepine derivative.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Cats; Chlordiazepoxide; Dia | 1970 |
Serum cholesterol in monkeys with chronic epileptic foci.
Topics: Animals; Cholesterol; Epilepsies, Partial; Epilepsy; Female; Haplorhini; Male; Pentylenetetrazole; S | 1971 |
Cerebral metabolism during induced seizures in man and animals.
Topics: Adenosine Triphosphate; Animals; Brain; Carbon Dioxide; Dogs; Electric Stimulation; Glucose; Haplorh | 1970 |
Anticonvulsant properties of the ketogenic diet in mice.
Topics: Age Factors; Animals; Anticonvulsants; Body Weight; Caseins; Dietary Fats; Electroshock; Fasting; Fe | 1972 |
Some neurochemical correlates of convulsive activity in the rat brain.
Topics: Animals; Blood Glucose; Brain; Brain Chemistry; Electroshock; Female; Fructosephosphates; Glucosepho | 1972 |
Effect of intermittent light stimulation singly and combined with pentylenetetrazol on the electroencephalogram and clinical response of the beagle dog.
Topics: Animals; Brain; Dog Diseases; Dogs; Electroencephalography; Female; Injections, Intravenous; Light; | 1972 |
Epilepsy or anesthesia with ketamine.
Topics: Anesthesia; Anesthetics; Animals; Cataplexy; Cats; Central Nervous System; Cyclohexanes; Depression; | 1972 |
Effect of various stresses on the incorporation of ( 3 H)orotic acid into goldfish brain RNA.
Topics: Animals; Avoidance Learning; Brain; Carbon Dioxide; Cyprinidae; Cytosine Nucleotides; Electroshock; | 1972 |
Effect of experimentally induced seizures on some amino acids and ammonia in rat brain.
Topics: Amino Acids; Aminobutyrates; Ammonia; Animals; Brain; Brain Chemistry; Electroshock; Female; Glutama | 1972 |
Substituted thiazolidones as anticonvulsants.
Topics: Animals; Anticonvulsants; Female; Ketones; Male; Mice; Pentylenetetrazole; Seizures; Structure-Activ | 1972 |
The effect of experimentally induced seizures on the concentration of tissue and blood magnesium.
Topics: Animals; Electroshock; Female; Magnesium; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; | 1972 |
Substituted 3,4,5-trimethoxybenzamides: correlation between inhibition of pyruvic acid oxidation and anticonvulsant activity.
Topics: Amides; Animals; Anticonvulsants; Benzoates; Benzyl Compounds; Brain; Cyclohexylamines; Infrared Ray | 1972 |
Substituted indolebenzylhydrazines as anticonvulsants.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Female; Hydrazines; Indoles; Male; Mice; Pentylenetetraz | 1972 |
Different central effects of the 5-HT antagonists mianserine and cyproheptadine.
Topics: Animals; Behavior, Animal; Cyproheptadine; Dibenzazepines; Drug Antagonism; Electroshock; Lethal Dos | 1972 |
An investigation of the pharmacological properties of homocarnosine.
Topics: Aminobutyrates; Animals; Barbiturates; Blood Pressure; Brain Stem; Central Nervous System; Cerebral | 1972 |
Ethanol dependence in the rat: its production and characteristics.
Topics: Alcoholism; Animals; Auditory Threshold; Behavior, Animal; Electroshock; Ethanol; Female; Humans; Pe | 1972 |
A new 2,6-difluorobenzodiazepinone.
Topics: Animals; Behavior, Animal; Benzazepines; Drug Synergism; Electroshock; Ethanol; Fluorine; Ketones; M | 1972 |
Effects of excitation and anaesthesia on the glutamine content of the rat brain with a reference to the administration of glutamine.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Delirium; Glutamates; Glutamine; Head; Huma | 1972 |
Retrograde amnesia for discriminated taste aversions: a memory deficit.
Topics: Amnesia; Animals; Apomorphine; Association; Avoidance Learning; Conditioning, Psychological; Discrim | 1972 |
Central nervous system depressants. 10. 1-Carbamoylbenzodiazepines.
Topics: Animals; Behavior, Animal; Benzazepines; Carbamates; Central Nervous System; Depression, Chemical; D | 1972 |
Pharmacologic evaluation of 3,4-dimethoxyphenylpropenes and 3,4-dimethoxyphenylpropanediols.
Topics: Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; | 1972 |
Suppression of seizure discharges and sleep spindles by lesions of the rostral thalamus.
Topics: Animals; Cats; Cerebral Cortex; Cortical Synchronization; Electroencephalography; Neural Inhibition; | 1972 |
Action of picric acid on the effects of some drugs acting on the central nervous system, with special reference to opioids.
Topics: Amphetamine; Analgesia; Analgesics; Animals; Benzimidazoles; Drug Synergism; Female; Male; Meperidin | 1971 |
Dispersion curve of responses evoked by visual stimuli. Method for analysis of stochastic mechanisms involved in information processing in the brain.
Topics: Adult; Alcohol Amnestic Disorder; Animals; Brain; Cats; Coma; Computers; Electroencephalography; Epi | 1971 |
Maturation of convulsogenic activity induced by leptazol in the albino rat.
Topics: Age Factors; Animals; Body Weight; Brain Stem; Catalepsy; Central Nervous System; Female; Humans; In | 1971 |
[Retrograde amnesia induced by corazole against a background of anesthesia].
Topics: Amnesia; Anesthesia, General; Animals; Conditioning, Classical; Escape Reaction; Ethyl Ethers; Human | 1971 |
Anticonvulsant effect of trimethadione in mice during continued treatment via the drinking water.
Topics: Animals; Anticonvulsants; Female; Male; Mice; Osmolar Concentration; Oxazoles; Pentylenetetrazole; S | 1971 |
[Experimental animal studies on the effect of trimethadione on acute and chronic epileptiform activity].
Topics: Animals; Anticonvulsants; Arousal; Behavior, Animal; Cerebral Cortex; Cobalt; Electroencephalography | 1971 |
[Central nervous activity and compared general pharmacology of glyoxylate, glycolate and glycolaldehyde].
Topics: Aldehydes; Animals; Anticonvulsants; Central Nervous System; Drug Antagonism; Glycolates; Glycols; G | 1971 |
Seizure induction by pentylenetetrazol in rodents receiving Candida albicans glycoprotein orally.
Topics: Administration, Oral; Animals; Candida; Disease Models, Animal; Drug Synergism; Female; Glycoprotein | 1971 |
Activation of fibrinolysis during electroconvulsive treatment.
Topics: Anesthesia, General; Arrhythmias, Cardiac; Cold Temperature; Convulsive Therapy; Electric Countersho | 1971 |
Release during convulsions of an unknown substance into the cerebral ventricles of the cats.
Topics: Animals; Brain; Cats; Cerebral Ventricles; Dopamine; Methysergide; Muscle Contraction; Pentylenetetr | 1971 |
Studies on neurochemical changes in experimental epilepsy.
Topics: Allyl Compounds; Aminobutyrates; Animals; Biogenic Amines; Brain Chemistry; Carboxy-Lyases; Cerebral | 1971 |
[Penetration of radioactive isotopes into regions of the brain during experimental convulsions].
Topics: Amygdala; Animals; Basal Ganglia; Blood-Brain Barrier; Brain; Cerebellum; Cerebral Cortex; Electric | 1971 |
Metabolism and anticonvulsant activity of diazepam in guinea pigs.
Topics: Adipose Tissue; Animals; Anticonvulsants; Brain; Chromatography, Gas; Diazepam; Drug Antagonism; Gui | 1971 |
Folic acid and convulsions in the rat.
Topics: Animals; Drug Interactions; Female; Folic Acid; Formates; Male; Methotrexate; Pentylenetetrazole; Ra | 1971 |
Time-dependent memory deficits produced by pentylene-tetrazol (Metrazol)--the effect of reinforcement magnitude.
Topics: Amnesia; Animals; Avoidance Learning; Conditioning, Psychological; Electroshock; Female; Humans; Mal | 1971 |
Pharmacological and biochemical studies on 2-amino-4-phenylsulphonylbenzenesulphonamide (NSD 3004): a new sulphonamide with anticonvulsant and carbonic anhydrase inhibitory properties.
Topics: Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Diuresis; Electroshock; Enzyme Activation; | 1971 |
[Brain tissue damage following the management of cardiazol-induced convulsions. Animal experimental contribution].
Topics: Animals; Brain; Cardiomyopathies; Cats; Cerebellum; Electroconvulsive Therapy; Electroshock; Frontal | 1969 |
Extracellular unit activity in cat cortex during the spike-wave complex.
Topics: Animals; Cats; Cerebral Cortex; Electric Stimulation; Electroencephalography; Electrophysiology; Mes | 1966 |
Effects of dimethyl sulfoxide and alphaglucochloralose on pentylenetetrazol convulsive thresholds in mice.
Topics: Animals; Anticonvulsants; Ataxia; Central Nervous System; Chloralose; Dimethyl Sulfoxide; Drug Syner | 1967 |
Generalized epileptic seizures, induced by "non-convulsant" substances. 2. Experimental study with special reference to ammonium chloride.
Topics: Adult; Ammonium Chloride; Animals; Cats; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; I | 1968 |
Correlative changes of pyridoxal kinase pyridoxal-5'-phosphate and glutamate decarboxylase in brain, during drug-induced convulsions.
Topics: Acetates; Aminobutyrates; Animals; Brain; Brain Chemistry; Carboxy-Lyases; Glutamates; Hydrazines; M | 1969 |
Effects of acute and chronic exposure to DDT and of DDT-drug interactions on experimental seizure responses.
Topics: Animals; Central Nervous System; DDT; Dieldrin; Electroshock; Female; Injections, Subcutaneous; Intu | 1970 |
Anticonvulsant properties of some newer monoamine oxidase inhibitors.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Drug Synergism; Fem | 1967 |
Pharmacogenetic correlates of pentylenetetrazol and electroconvulsive seizure thresholds in mice.
Topics: 5-Hydroxytryptophan; Acetates; Amines; Animals; Brain Chemistry; Electroshock; Female; Genotype; Hyb | 1968 |
Effects of N, N' -diphenyldicarbamate-1,1-demethylol cyclopentane (Carmalon) on the spinal cord reflexes.
Topics: Animals; Atropine; Barbiturates; Cyclopentanes; Depression, Chemical; Electric Stimulation; Male; Me | 1968 |
Metrazol test for rapid screening of anticonvulsants.
Topics: Animals; Anticonvulsants; Electroshock; Injections, Subcutaneous; Mice; Pentylenetetrazole; Phenytoi | 1969 |
Central anti-serotonin activity of two newer acetamidine compounds, B.W. 50 1 C 67 and B.W. 204 C 67.
Topics: Acetamides; Acetates; Amides; Animals; Anticonvulsants; Drug Synergism; Female; Male; Pentylenetetra | 1971 |
Intra- and extra-cellular potentials from "idle" cells in cerebral cortex of cat.
Topics: Animals; Cats; Cerebral Cortex; Electric Stimulation; Membrane Potentials; Microelectrodes; Pentylen | 1971 |
Stereo-electroencephalographic observations on the psychomotor seizure.
Topics: Amygdala; Cerebral Cortex; Electric Stimulation; Electroencephalography; Electrophysiology; Epilepsy | 1966 |
Blockade of biogenic amine synthesis: its effect on the responses to leptazol and dexamphetamine in rats.
Topics: Amines; Animals; Dextroamphetamine; Dopamine; Drug Synergism; Male; Methyltyrosines; Norepinephrine; | 1969 |
[Dynamics of changes in the RNA content in spinal cord neurons and neuroglia during corasole-induced seizures and rest following seizures].
Topics: Animals; Cytoplasm; Motor Neurons; Neuroglia; Pentylenetetrazole; Rats; RNA; Seizures; Spectrophotom | 1969 |
Animal studies comparing the neuropharmacological profile of a trifluoperazine HCl-amobarbital combination with that of the individual components.
Topics: Amobarbital; Animals; Central Nervous System; Chlordiazepoxide; Drug Synergism; Female; Hypnosis; Ma | 1969 |
Modification of audiogenic and pentylenetetrazol seizures with gamma-aminobutyric acid, norepinephrine and serotonin.
Topics: Aminobutyrates; Animals; Female; Male; Mice; Noise; Norepinephrine; Pentylenetetrazole; Seizures; Se | 1969 |
[Cytophotometric analysis of nucleic and protein metabolism in motor and sensory neurons of the spinal cord and its neuroglia in convulsions induced by corazole].
Topics: Animals; Cell Nucleus; Cytoplasm; Ganglia, Spinal; Karyometry; Methods; Motor Neurons; Neuroglia; Ne | 1969 |
[Combined action of diazepam, alpha-methyldopa and reserpine on the effect of pentamethylenetetrazole in mice].
Topics: Animals; Diazepam; Drug Antagonism; Drug Synergism; Male; Methyldopa; Mice; Pentylenetetrazole; Rese | 1969 |
Determination of the anticonvulsant potency of unmetabolized trimethadione.
Topics: Animals; Anticonvulsants; Female; Male; Mice; Pentylenetetrazole; Seizures; Trimethadione | 1969 |
Influence of age and brief auditory conditioning upon experimental seizures in mice.
Topics: Acoustic Stimulation; Age Factors; Animals; Biological Evolution; Body Weight; Brain; Conditioning, | 1969 |
Studies on the anticonvulsant action of diazepam.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Chromatography, Gas; Diazepam; Mice; Oxazepam; Pen | 1970 |
Some biochemical correlates of convulsive activity in rats.
Topics: Animals; Brain Chemistry; Electroshock; Glucose; Hexokinase; Hexosephosphates; Lactates; Pentylenete | 1970 |
Effect of dexamethasone on altered brain vascular permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Cats; Dexamethasone; Nerve Tissue Proteins; Pentylenetetrazole; | 1970 |
Some neurochemical aspects of pentamethylenetetrazole convulsive activity in rat brain.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acids; Aminobutyrates; Animals; Brain; Centrifuga | 1970 |
Brain adenosine triphosphate: decreased concentration precedes convulsions.
Topics: Adenosine Triphosphate; Animals; Brain; Hydroxylamines; Hypoxia; Male; Pentylenetetrazole; Rats; Sei | 1970 |
Effects of DDT and of drug-DDT interactions on electroshock seizures in the rat.
Topics: Animals; Central Nervous System; DDT; Drug Antagonism; Drug Synergism; Electroshock; Female; Pentoba | 1970 |
Potassium accumulation in interstitial space during epileptiform seizures.
Topics: Animals; Brain; Cats; Cerebral Cortex; Electroencephalography; Electroshock; Extracellular Space; Hi | 1970 |
Some pharmacological properties of N,N-disubstituted dithiocarbamates and their effect on the brain catecholamine levels.
Topics: Amphetamine; Animals; Behavior, Animal; Brain; Brain Chemistry; Catecholamines; Depression, Chemical | 1970 |
Effects of various conditions on the movement of carbon atoms derived from glucose into and out of protein in rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Cerebral Cortex; | 1970 |
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; | 1970 |
Excitability of partiallydeafferented cortex. I. Macroectrode studies.
Topics: Acetylcholine; Animals; Cats; Denervation; Electric Stimulation; Electrocoagulation; Electrodes; Ele | 1970 |
Pharmacological comparison of R(+), S(-) and racemic secobarbital in mice.
Topics: Anesthesia; Animals; Male; Mice; Pentylenetetrazole; Secobarbital; Seizures; Stereoisomerism; Strych | 1970 |
Metrazol tolerance in a "normal" volunteer population. A ten year follow-up report.
Topics: Affective Symptoms; Drug Tolerance; Electroencephalography; Female; Follow-Up Studies; Humans; Male; | 1970 |
Pharmacologic interactions of albutoin with other anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Drug Synergism; Electroshock; Hydantoins; Male; Mice; Pentylenetetrazole; | 1970 |
[Effect of acetone upon pentamethylenetetrazole convulsions].
Topics: Acetone; Animals; Central Nervous System; Female; Male; Mice; Pentylenetetrazole; Reserpine; Seizure | 1970 |
Pharmacology of alkyl and hydroxyalkylpyrazines.
Topics: Animals; Anticonvulsants; Central Nervous System; Glucose; Hypnotics and Sedatives; Imidazoles; Male | 1970 |
Synthesis and anticonvulsant properties of some derivatives of N-methyl-2-phenylsuccinimide. II.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Infrared Rays; Magnetic Reson | 1970 |
Metrazol seizures in rats: effect of p-chlorophenylalanine.
Topics: Animals; Male; Pentylenetetrazole; Phenylalanine; Rats; Seizures | 1970 |
Inferior colliculus lesion and audiogenic seizure susceptibility.
Topics: Animals; Behavior, Animal; Cats; Female; Functional Laterality; Male; Methionine Sulfoximine; Noise; | 1970 |
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.
Topics: Aggression; Animals; Chlordiazepoxide; Diazepam; Electroshock; Exploratory Behavior; Humans; Locomot | 1970 |
Electroshock and caudate nucleus dopamine.
Topics: Animals; Brain Chemistry; Caudate Nucleus; Dopamine; Electroshock; Pentylenetetrazole; Rabbits; Seiz | 1970 |
Anticonvulsant drugs and self-stimulation rates in rats.
Topics: Acetazolamide; Animals; Chlordiazepoxide; Electrodes; Male; Meprobamate; Pentobarbital; Pentylenetet | 1970 |
Structure-activity correlations for anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Computers; Electroshock; Mathematics; Mice; | 1970 |
Effect of metal ions on oxygen toxicity.
Topics: Animals; Atmospheric Pressure; Cobalt; Hydroxylamines; Hyperbaric Oxygenation; Injections, Intraperi | 1970 |
Brain dmage in rats following pentylenetetrazole and high pressure oxygen.
Topics: Animals; Brain; Brain Diseases; Cerebrovascular Circulation; Female; Hyperbaric Oxygenation; Paralys | 1970 |
Reversible changes in glutamine levels in the cat cerebral cortex evoked by afferent electrical stimulation and by administration of pentamethylenetetrazole (pentylenetetrazol).
Topics: Animals; Brachial Plexus; Cats; Cerebral Cortex; Chromatography; Electric Stimulation; Female; Freez | 1970 |
Correlation between the duration of the anticonvulsant activity of diazepam and its physiological disposition in mice.
Topics: Adipose Tissue; Animals; Anticonvulsants; Benzazepines; Brain; Brain Chemistry; Chemical Phenomena; | 1970 |
[Activity of aldolase, lactate dehydrogenase and content of lactic and pyroracemic acids in different areas of the brain in rat, with repeated convulsions evoked by corazole].
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Diencephalon; Fructose-Bisphosphate Aldolase; L-Lactate | 1970 |
[Anticonvulsant action of imipramine and imitriptyline associated with phenobarbital, phenytoin and diazepam].
Topics: Amitriptyline; Animals; Anticonvulsants; Diazepam; Electroshock; Imipramine; Mice; Pentylenetetrazol | 1970 |
[Activity of the pyramidal system of cats during cardiazol-induced disorders].
Topics: Animals; Cats; Electroencephalography; Pentylenetetrazole; Pyramidal Tracts; Seizures | 1970 |
Brain RNA hydrogen bonding in young and old rats after metrazol-induced convulsion.
Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Chemical Phenomena; Chemistry; Formaldehyde; Hydr | 1970 |
[Protective action of N-acetylaspartic acid and N-acetylaspartyl-glutamic acid in convulsive seizures induced with pentamethylene-tetrazole in rats].
Topics: Acetates; Aspartic Acid; Brain; Glutamates; Pentylenetetrazole; Seizures | 1970 |
Anticonvulsant and motor depressant effects of Diazepam.
Topics: Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Depression, Chemical; Diazepam; D | 1970 |
Anticonvulsant properties of diphenylthiohydantoin.
Topics: Animals; Drug Antagonism; Electroencephalography; Electroshock; Hindlimb; Male; Myoclonus; Pentylene | 1970 |
Concerning the depressant activity of analeptics (pentylenetetrazol, bemegride, nikethamide, picrotoxin).
Topics: Anesthesia; Animals; Barbiturates; Bemegride; Depression, Chemical; Guinea Pigs; Nikethamide; Nitrou | 1970 |
A benzazepinone: carbon analog of diazepam.
Topics: Animals; Benzazepines; Blood Pressure; Central Nervous System; Depression, Chemical; Hypnotics and S | 1970 |
[Effect of coumarin from Melilotus officinalis on the convulsion threshold of the central nervous system in rats and guinea pigs].
Topics: Animals; Coumarins; Disease Models, Animal; Guinea Pigs; Isoniazid; Pentylenetetrazole; Plant Extrac | 1970 |
Synthesis and anticonvulsant activity of substituted 2-thioquinazolin-4-ones. I. Preliminary studies.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Male; Mice; Pentylenetetrazol | 1971 |
Neuropharmacological properties of Su17595A a chlorpromazine-like central nervous system depressant.
Topics: Animals; Blood Pressure; Brain Stem; Caffeine; Cats; Chlordiazepoxide; Chlorpromazine; Cocaine; Depr | 1971 |
The effect of anti-metabolites on leptazol induced fits in rats.
Topics: Animals; Antimetabolites; Azathioprine; Brain; Cytarabine; Daunorubicin; Fluorouracil; Folic Acid; F | 1971 |
A comparison of the anticonvulsant properties of 2-diethylaminopento-4-ynoyl-2',6'-xylidide (WY 21745) with lignocaine, phenytoin, phenobarbitone and trimethadione.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Drug Antagonism; Electroshock; Lethal Dose 50; Lidocai | 1971 |
Simultaneous and instantaneous blood flow and tissue gas measurements in experimental "stroke" therapy.
Topics: Animals; Argon; Blood Flow Velocity; Brain; Carbon Dioxide; Cerebrovascular Circulation; Cerebrovasc | 1971 |
[The biochemical basis for epileptic seizures elicited in animals].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Ammonia; Animals; Brain; Cerebellum; Cerebral Cortex; C | 1971 |
Induced hypercholesteremia and decreased susceptibility to seizures in experimental animals.
Topics: Animals; Cholesterol; Diet; Diet Therapy; Hypercholesterolemia; Lipid Metabolism; Male; Mice; Pentyl | 1971 |
Topochemical aspects of nucleic acid and protein metabolism within the neuron-neuroglia unit of the spinal cord anterior horn.
Topics: Adaptation, Physiological; Animals; Cats; Cytoplasm; DNA; Electric Stimulation; Epinephrine; Female; | 1971 |
[On the capillaries and the perivascular structures of the area postrema of the rabbit and on its behavior in pentamethylenetetrazol- (cardiazol-)convulsion].
Topics: Animals; Basement Membrane; Capillaries; Cerebral Ventricles; Microscopy; Microscopy, Electron; Pent | 1967 |
Effect of glycosine on the higher nervous activity.
Topics: Animals; Anticonvulsants; Blood Pressure; Cocaine; Depression, Chemical; Heart; Higher Nervous Activ | 1967 |
[Action of ionizing radiations on some biochemical and bioelectrical activities of the central nervous system].
Topics: Aminobutyrates; Animals; Brain; Carboxy-Lyases; Central Nervous System; Cerebral Cortex; Cholinester | 1967 |
[Relationship between convulsions induced by toxic substances and anticonvulsants].
Topics: Acetazolamide; Anilides; Animals; Anticonvulsants; Female; Methacholine Compounds; Mice; Pentylenete | 1967 |
[Experimental study on the seizure wave induced by intravenous injection of megimide--in comparison with the induction pattern by metrazol].
Topics: Animals; Bemegride; Cats; Cerebral Cortex; Electroencephalography; Injections, Intravenous; Pentylen | 1967 |
[Neurophysiological studies with 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-on in animal experiments].
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Depression, Chemical; Drug Synergism; Electric Stim | 1967 |
[Experimental retrograde amnesias in mice].
Topics: Amnesia; Animals; Behavior, Animal; Brain Injuries; Humans; Mice; Pentylenetetrazole; Seizures | 1967 |
[Specific binding ability of polyvinlypyrrolidone].
Topics: Alcohols; Animals; Binding Sites; Body Temperature; Dextrans; Dialysis; Drug Synergism; Mice; Pentyl | 1967 |
Cerebral amino acids and lipids in drug-induced status epilepticus.
Topics: Amino Acids; Ammonia; Animals; Bemegride; Brain Chemistry; Dogs; Lipids; Male; Pentylenetetrazole; S | 1968 |
Effects of pentylenetetrazol on memory storage in mice.
Topics: Animals; Cerebral Cortex; Discrimination Learning; Electroencephalography; Electrophysiology; Female | 1968 |
Anticonvulsant activity of antiparkinsonism agents.
Topics: Animals; Anticonvulsants; Child; Child, Preschool; Electroshock; Female; Glaucoma; Humans; Infant; M | 1968 |
Comparative effects of hyperbaric oxygen and pentylenetetrazol on lung weight and non-protein sulfhydryl content of experimental animals.
Topics: Animals; Depression, Chemical; Guinea Pigs; Hyperbaric Oxygenation; Liver; Lung; Mice; Organ Size; O | 1968 |
Seizure induction by pentylenetetrazol in animals experimentally infected with Candida albicans.
Topics: Animals; Candidiasis; Electric Stimulation; Female; Mice; Pentylenetetrazole; Rats; Seizures; Spleen | 1968 |
Synthesis and pharmacological evaluation of some tetrahydrooxadiazinones and some dihydroaminooxadiazines.
Topics: Animals; Antidepressive Agents; Chemical Phenomena; Chemistry, Physical; Drug Antagonism; Ephedrine; | 1968 |
The effect of intraperitoneal injections of hyperosmotic solutions on convulsions induced by drugs and hyperbaric oxygen.
Topics: Aminobutyrates; Animals; Brain Diseases; Dehydration; Glucose; Hyperbaric Oxygenation; Hypertonic So | 1968 |
An epileptogenic focus in the frog telencephalon. Pathways of propagation of focal activity.
Topics: Animals; Anura; Brain Stem; Electroencephalography; Functional Laterality; Hippocampus; Limbic Syste | 1968 |
[Experimental studies on the influence of Lasix on the occurrence of cardiazol convulsions].
Topics: Animals; Furosemide; Pentylenetetrazole; Rats; Seizures | 1968 |
Effect of diazepam (Valium) on experimental seizures in unanesthetized cat.
Topics: Animals; Cats; Cerebral Cortex; Coma; Diazepam; Electroencephalography; Light; Pentylenetetrazole; P | 1968 |
Relationship of brain serotonin to convulsions.
Topics: Animals; Brain Chemistry; Brain Stem; Diencephalon; Pentylenetetrazole; Rabbits; Seizures; Serotonin | 1968 |
Further studies on chemically induced siezures and their antagonism by anticonvulsants during postnatal development in the mouse.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Mice; Pentylenetetrazole; Phenobarbital; Picrotox | 1968 |
The effect of selected neuromuscular blocking agents on the duration of pentylenetetrazol-induced sezures.
Topics: Animals; Bromides; Cats; Chlorides; Decamethonium Compounds; Female; Gallamine Triethiodide; Male; P | 1968 |
The effect of certain benzodaizepines on the threshold for pentylenetetrazol-induced seizures in the cat.
Topics: Animals; Benzazepines; Cats; Chlordiazepoxide; Diazepam; Pentylenetetrazole; Seizures; Time Factors | 1968 |
[Metabolic investigations of epileptic seizures. The activity of the glutamate decarboxylase prior to and during experimentally produced convulsions].
Topics: Animals; Aspartic Acid; Brain; Carboxy-Lyases; Electroshock; Female; Glutamates; In Vitro Techniques | 1968 |
[The action of alpha-methyldopa on the convulsive and lethal effects of pentamethylenetetrazol in mice].
Topics: Animals; Male; Methyldopa; Mice; Pentylenetetrazole; Seizures | 1968 |
Gamma-amino acid esters and the central nervous system.
Topics: Aminobutyrates; Animals; Body Temperature; Central Nervous System; Esters; Male; Mice; Motor Activit | 1968 |
The effect of chronic administration of sodium barbitone on chemically and electrically induced convulsions in the rat.
Topics: Animals; Barbiturates; Electroshock; Female; Pentylenetetrazole; Rats; Seizures | 1968 |
The central nervous effects of bis-(4-aminophenyl)-alkyl derivatives.
Topics: Animals; Barbiturates; Blood-Brain Barrier; Brain; Chickens; Drug Synergism; Electroencephalography; | 1968 |
Electrophysiological investigations on homopantothenic acid.
Topics: Animals; Brain; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Male; Pantothenic | 1968 |
EEG and convulsive threshold changes produced by pineal extract administration.
Topics: Action Potentials; Animals; Brain; Cats; Electric Stimulation; Electroencephalography; Evoked Potent | 1968 |
Neuropharmacological comparison of subcortical actions of anticholinergic compounds.
Topics: Animals; Atropine; Benzilates; Diencephalon; Evoked Potentials; Hallucinogens; Mesencephalon; Muscle | 1968 |
On the effect of cardiazol and picrotoxin on cats with crossed blood circulation.
Topics: Animals; Blood Transfusion; Cats; Electroencephalography; Pentylenetetrazole; Picrotoxin; Seizures | 1968 |
[On the inflence of fluid volume on the efficacy of bemegride, Pentetrazole and picrotoxin in phenobarbital poisoning].
Topics: Animals; Bemegride; Mice; Pentylenetetrazole; Pharmaceutical Vehicles; Phenobarbital; Picrotoxin; Se | 1968 |
Bioelectrically controlled convulsion treatment of endogenous psychoses under general anaesthesia and muscular relaxation. I. Changes of the passive EEG.
Topics: Adult; Aged; Anesthesia, General; Bipolar Disorder; Convulsive Therapy; Electrocardiography; Electro | 1968 |
[Bioelectrically controlled convulsion treatment of endogenous psychoses under general anaesthesia and muscular relaxation. II. EEG and neurophysiological interpretation of the Metrazol convulsion].
Topics: Anesthesia, General; Brain; Convulsive Therapy; Electroencephalography; Humans; Muscles; Neurophysio | 1968 |
[Bioelectrically controlled convulsion treatment of endogenous psychoses under general anaesthesia and muscular relaxation. 3. The EEG during electroconvulsive treatment].
Topics: Anesthesia, General; Electroconvulsive Therapy; Electroencephalography; Humans; Methods; Muscles; Ne | 1968 |
Changes in blood-brain permeability during pharmacologically induced convulsions.
Topics: Animals; Autoradiography; Blood Pressure; Blood-Brain Barrier; Brain; Capillary Permeability; Carbon | 1968 |
[Changes of the cardiazol convulsing threshold induced by chronic "irritation" of the caudate nucleus].
Topics: Animals; Cats; Caudate Nucleus; Cobalt; Pentylenetetrazole; Seizures; Stimulation, Chemical | 1968 |
Certain aspects of pharmacological profiles of chlordiazepoxide and diazepam.
Topics: Analgesics; Animals; Benzazepines; Chlordiazepoxide; Diazepam; Drug Antagonism; Drug Synergism; Elec | 1968 |
Epileptic focus in the forebrain of the turtle.
Topics: Animals; Anura; Brain; Cerebral Cortex; Electrodes; Electroencephalography; Electrophysiology; Elect | 1969 |
Toxicity of methylimidazoles.
Topics: Animals; Anticonvulsants; Chickens; Chlordiazepoxide; Electroencephalography; Heart Rate; Imidazoles | 1969 |
Pharmacological significances of peptidase and proteinase in the brain. I. Enzymatic inactivation of bradykinin in rat brain.
Topics: Animals; Biological Assay; Bradykinin; Brain; Brain Stem; Carboxypeptidases; Cell Nucleus; Cerebellu | 1969 |
Effects of adrenalectomy and repeated convulsions on responses of rats to flurothyl.
Topics: Adrenalectomy; Animals; Body Weight; Ethers; Fluorine; Male; Pentylenetetrazole; Rats; Seizures; Sod | 1969 |
Effects of acoustic priming on audiogenic, electroconvulsive, and chemoconvulsive seizures.
Topics: Animals; Auditory Perception; Breeding; Critical Period, Psychological; Electroshock; Hybridization, | 1969 |
Anti-convulsant action of anabolic steroids.
Topics: Aminobutyrates; Anabolic Agents; Animals; Brain Chemistry; Electroshock; Male; Pentylenetetrazole; R | 1969 |
The hydrational effect of leptazol and its theoretical connection with glucose deficiency in the haemolysis of rabbit erythrocytes.
Topics: Animals; Barbiturates; Blood Glucose; Brain; Erythrocytes; Glucose; Hemolysis; Malonates; Pentylenet | 1969 |
Failure to detect a synergist for pentylenetetrazol in the blood of psychotic children.
Topics: Adolescent; Animals; Blood; Child; Drug Synergism; Female; Humans; Male; Mice; Pentylenetetrazole; P | 1969 |
Astroglial swelling and phosphohydrolases in cerebral cortex of metrazol convulsant rats.
Topics: Animals; Biological Transport, Active; Cerebral Cortex; Microscopy, Electron; Neuroglia; Pentylenete | 1969 |
On the central action of some oxoindole compounds.
Topics: Absorption; Amphetamine; Animals; Blood Pressure; Central Nervous System; Depression; Drug Antagonis | 1969 |
[Metabolic studies of epileptic seizures. The concentration of free amino acids in cerebral tissue prior to and during cerebral seizures].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Centrifugation; Chromatography, | 1969 |
Anti-convulsive action of gamma-aminobutyryl choline.
Topics: Animals; Anticonvulsants; Blood Pressure; Blood-Brain Barrier; Body Temperature; Choline; Dogs; Elec | 1965 |
[Comparative study of some extracardiac effects of cardiac glycosides].
Topics: Animals; Behavior, Animal; Cardiac Glycosides; Cats; Dogs; Electroconvulsive Therapy; Emetics; Mice; | 1965 |
Some central effects of SQ 10,643 [2'3-(-dimethlaminopropylthio) cinnamanilide hydrochloride], a potent serotonin antagonist.
Topics: Animals; Avoidance Learning; Behavior, Animal; Body Temperature; Cats; Electroconvulsive Therapy; El | 1965 |
Some aspects of the action of valium and of librium on the electrical activity of the rabbit brain.
Topics: Animals; Anticonvulsants; Brain; Chlordiazepoxide; Diazepam; Electroconvulsive Therapy; Electroencep | 1965 |
The metrazol activation of the normal brain.
Topics: Adult; Brain; Brain Diseases; Electroencephalography; Epilepsy; Humans; Male; Pentylenetetrazole; Se | 1965 |
[Cardiazol epilepsy and the caudate nucleus].
Topics: Animals; Caudate Nucleus; Electric Stimulation; Electroencephalography; Pentylenetetrazole; Rabbits; | 1965 |
Pharmacodynamics of cryogenine, an alkaloid isolated from Hiemia salicifolia Link and Otto. II.
Topics: Acetylcholine; Alkaloids; Analgesics; Animals; Anura; Behavior, Animal; Chlorpromazine; Conditioning | 1965 |
The rapid development of physical dependence on barbiturates.
Topics: Animals; Cats; Denervation; Humans; Pentobarbital; Pentylenetetrazole; Seizures; Substance Withdrawa | 1965 |
[Effect of convulsive doses of cardiazol on blood sugar in curarized rabbits].
Topics: Animals; Blood Glucose; Pentylenetetrazole; Rabbits; Seizures | 1965 |
[Dissociation of the convulsive and hyperglycemic effects of the injection of cardiazol in the rat].
Topics: Animals; Hyperglycemia; Pentylenetetrazole; Rats; Seizures | 1965 |
Elevation of gamma-aminobutyric acid in brain with amino-oxyacetic acid and susceptibility to convulsive seizures in mice: a quantitative re-evaluation.
Topics: Acetates; Adenosine Triphosphate; Aminobutyrates; Animals; Brain; Carboxy-Lyases; Electroconvulsive | 1966 |
Structure-activity relationships of some centrally active dialkyl substituted propanediol sulfites.
Topics: Animals; Blood Pressure; Central Nervous System; Mice; Pentylenetetrazole; Propylene Glycols; Seizur | 1966 |
[Phenothiazines and metrazol convulsions in the mouse].
Topics: Animals; Chlorpromazine; Mice; Pentylenetetrazole; Perphenazine; Seizures; Thioridazine | 1966 |
Anticonvulsant and convulsant effects of chemically related thiosemicarbazide, thiourea and urea derivatives.
Topics: Aldehydes; Animals; Anticonvulsants; Electroconvulsive Therapy; Mice; Pentylenetetrazole; Pyridines; | 1966 |
Destructive effects of prolonged status epilepticus.
Topics: Animals; Cats; Electrocardiography; Electroencephalography; Electroshock; Penicillins; Pentylenetetr | 1966 |
The electrical excitability of isolated cortex during barbiturate withdrawal.
Topics: Animals; Barbiturates; Cats; Cerebral Cortex; Electric Stimulation; Female; Humans; In Vitro Techniq | 1966 |
Acetylcholine released from cerebral cortex in relation to state of activation.
Topics: Acetylcholine; Anesthesia; Animals; Atropine; Cats; Cerebral Cortex; Electric Stimulation; Electroen | 1966 |
Convulsions and sugar transport in brain.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cerebral Cortex; Child; Electric Stimulat | 1966 |
Barometric pressure and seizures.
Topics: Animals; Atmospheric Pressure; Mice; Pentylenetetrazole; Seizures | 1966 |
Convulsive properties of four local anesthetic preparations.
Topics: Aminobenzoates; Anesthetics, Local; Animals; Benzoates; Epinephrine; Female; Lidocaine; Male; Pentyl | 1966 |
[The influence of ABC aralosides on the action of certain analeptics].
Topics: Animals; Camphor; Drug Antagonism; Mice; Pentylenetetrazole; Saponins; Seizures; Spinal Cord; Strych | 1966 |
Effects of Reichstein's compound S, strychnine and leptazol perfused through cerebral ventricles of cats.
Topics: Amygdala; Animals; Behavior, Animal; Body Temperature Regulation; Brain; Cats; Cerebral Cortex; Cere | 1966 |
[Intercellular perivascular brain edema following pentamethylenetetrazole ("Cardiazol") convulsions].
Topics: Animals; Basement Membrane; Brain Edema; Microscopy, Electron; Pentylenetetrazole; Rabbits; Seizures | 1966 |