pentylenetetrazole has been researched along with Abdominal Epilepsy in 32 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 7.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| "In patients with suspected epilepsy, an EEG "activation" with bemegride can be performed as last link of the diagnostic chain." | 7.67 | [EEG activation with bemegride in epilepsy diagnosis. 1: Literature review]. ( Bülau, P; Fröscher, W, 1984) |
| "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide." | 3.74 | Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. ( Choi, D; Harris, RH; Kohn, H; Kupferberg, HJ; Stables, JP; Stöhr, T; Walton, N; White, HS, 2007) |
| "In patients with suspected epilepsy, an EEG "activation" with bemegride can be performed as last link of the diagnostic chain." | 3.67 | [EEG activation with bemegride in epilepsy diagnosis. 1: Literature review]. ( Bülau, P; Fröscher, W, 1984) |
| "The results of surgical treatment of intractable epilepsy seizures in a group of patients investigated with the intracarotid amobarbital-pentylenetetrazol EEG test were analyzed." | 3.65 | Role of the intracarotid amobarbital-pentylenetetrazol EEG test in the diagnosis and surgical treatment of patients with complex seizure problems. ( Altuzarra, A; Garretson, H; Gloor, P; Rasmussen, T, 1976) |
| "In conclusion, the results confirm a genetic susceptibility in GAERS and/or resistance in inbred non-epileptic rats to focal and generalized seizures involving the cortex." | 1.30 | Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy. ( Boehrer, A; Brailowsky, S; Marescaux, C; Montiel, T; Vergnes, M, 1999) |
| "One-third of migraine patients, mostly of young age, suffering from migraine with aura and basilar migraine had such consciousness disorders as stupefaction and syncopes." | 1.29 | [Migraine and epilepsy: clinical comparisons and the characteristics of the cerebral blood circulation]. ( Larikova, TI; Shestakov, VV, 1994) |
| "Midazolam (0." | 1.28 | Intravenous midazolam suppression of pentylenetetrazol-induced epileptogenic activity in a porcine model. ( Bittle, BK; Jaimovich, DG; Noorani, PA; Osborne, JS; Shabino, CL, 1990) |
| "Human beings with partial epilepsy and demonstrable cerebral lesions show, in addition to ipsilateral epileptiform EEG discharges, apparently independent epileptiform discharges from the opposite hemisphere." | 1.27 | The relevance of secondary epileptogenesis to the treatment of epilepsy: kindling and the mirror focus. ( Goldensohn, ES, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (62.50) | 18.7374 |
| 1990's | 9 (28.13) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Godlevsky, LS | 1 |
| Drozdova, GA | 1 |
| Kobolev, EV | 1 |
| Mustyatsa, VF | 1 |
| Polyasnyi, VA | 1 |
| Rowley, NM | 1 |
| White, HS | 2 |
| Stöhr, T | 1 |
| Kupferberg, HJ | 1 |
| Stables, JP | 1 |
| Choi, D | 1 |
| Harris, RH | 1 |
| Kohn, H | 1 |
| Walton, N | 1 |
| Goldensohn, ES | 1 |
| Holmes, GL | 1 |
| Albala, BJ | 1 |
| Moshé, SL | 1 |
| Fröscher, W | 1 |
| Bülau, P | 1 |
| Ricci, GF | 1 |
| De Feo, MR | 1 |
| Mecarelli, O | 1 |
| Shestakov, VV | 1 |
| Larikova, TI | 1 |
| Karpova, MN | 3 |
| Pankov, OIu | 3 |
| Germane, SK | 2 |
| Klusha, VE | 2 |
| Duburs, G | 1 |
| Velísek, L | 1 |
| Vondricková, R | 1 |
| Mares, P | 1 |
| Löscher, W | 1 |
| Hönack, D | 1 |
| Theodore, WH | 1 |
| Balish, M | 1 |
| Leiderman, D | 1 |
| Bromfield, E | 1 |
| Sato, S | 1 |
| Herscovitch, P | 1 |
| Schwindt, W | 1 |
| Nicholson, C | 1 |
| Lehmenkühler, A | 1 |
| Brailowsky, S | 1 |
| Montiel, T | 1 |
| Boehrer, A | 1 |
| Marescaux, C | 1 |
| Vergnes, M | 1 |
| Vol'f, MSh | 1 |
| Bradford, HF | 1 |
| Dodd, PR | 1 |
| Gloor, P | 3 |
| Rasmussen, T | 1 |
| Altuzarra, A | 1 |
| Garretson, H | 1 |
| Kryzhanovskiĭ, GN | 3 |
| Glebov, RN | 2 |
| Jaimovich, DG | 1 |
| Shabino, CL | 1 |
| Noorani, PA | 1 |
| Bittle, BK | 1 |
| Osborne, JS | 1 |
| Binnie, CD | 1 |
| Van Emde Boas, W | 1 |
| Wauquier, A | 1 |
| Dubur, GIa | 1 |
| Bartsevich, LB | 1 |
| Lobasiuk, BA | 1 |
| Zherebin, IuL | 1 |
| Osipova, LA | 1 |
| Hausser-Hauw, C | 1 |
| Bancaud, J | 1 |
| Gallitto, G | 1 |
| Musolino, R | 1 |
| Aliquò, G | 1 |
| Bruno, A | 1 |
| De Domenico, P | 1 |
| Marlara, CE | 1 |
| Marabello, L | 1 |
| Puglisi, RM | 1 |
| Sturniolo, R | 1 |
| Di Perri, R | 1 |
| Shandra, AA | 1 |
| Godlevskiĭ, LS | 1 |
| Browne, TR | 1 |
| Penry, JK | 1 |
| Testa, G | 1 |
| Schmalbach, K | 1 |
| Lloyd-Smith, DL | 1 |
| Kopeloff, LM | 1 |
| Alexander, GJ | 1 |
| Mukawa, J | 1 |
| Jinnai, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| Effects of Levetiracetam on Cortical Excitability in Humans[NCT00006191] | 14 participants | Observational | 2000-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for pentylenetetrazole and Abdominal Epilepsy
| Article | Year |
|---|---|
Contributions of electroencephalography and electrocorticography to the neurosurgical treatment of the epilepsies.
Topics: Amobarbital; Bemegride; Cerebral Cortex; Electric Stimulation; Electrodes; Electrodes, Implanted; El | 1975 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
The electroencephalogram as a diagnostic aid in neurosurgery: a review.
Topics: Adult; Age Factors; Amobarbital; Brain Diseases; Brain Injuries; Brain Neoplasms; Child; Child, Pres | 1969 |
29 other studies available for pentylenetetrazole and Abdominal Epilepsy
| Article | Year |
|---|---|
Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy.
Topics: Animals; Anticonvulsants; Brain; Brain Waves; Cerebral Cortex; Diazepam; Drug Synergism; Epilepsies, | 2013 |
Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models.
Topics: Animals; Anticonvulsants; Biophysics; Cornea; Disease Models, Animal; Drug Evaluation, Preclinical; | 2010 |
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Topics: Acetamides; Animals; Anticonvulsants; Bicuculline; Cobalt; Convulsants; Electroshock; Epilepsies, Pa | 2007 |
The relevance of secondary epileptogenesis to the treatment of epilepsy: kindling and the mirror focus.
Topics: Adult; Animals; Brain; Electroencephalography; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; | 1984 |
Effect of a single brief seizure on subsequent seizure susceptibility in the immature rat.
Topics: Animals; Disease Susceptibility; Electroshock; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; | 1984 |
[EEG activation with bemegride in epilepsy diagnosis. 1: Literature review].
Topics: Adolescent; Adult; Anticonvulsants; Bemegride; Dose-Response Relationship, Drug; Electroencephalogra | 1984 |
Status epilepticus and brain maturation.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Electroencephalography; Epilepsies, Partia | 1984 |
[Migraine and epilepsy: clinical comparisons and the characteristics of the cerebral blood circulation].
Topics: Blood Flow Velocity; Cerebrovascular Circulation; Electroencephalography; Epilepsies, Partial; Epile | 1994 |
[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dihydropyridines; Drug Evaluation, Preclinical; Drug Ther | 1993 |
Models of simple partial and absence seizures in freely moving rats: action of ketamine.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalo | 1993 |
Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electrodes; | 1993 |
Effect of seizures on cerebral blood flow measured with 15O-H2O and positron emission tomography.
Topics: Adult; Cerebrovascular Circulation; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, | 1996 |
Critical volume of rat cortex and extracellular threshold concentration for a pentylenetetrazol-induced epileptic focus.
Topics: Agar; Animals; Cerebral Cortex; Convulsants; Diffusion; Dose-Response Relationship, Drug; Epilepsies | 1997 |
Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy.
Topics: Animals; Convulsants; Electroencephalography; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Gene | 1999 |
[Psychotropic drugs in the clinical picture of epilepsy (review of the literature)].
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbamazepine; C | 1975 |
Convulsions and activation of epileptic foci induced by monosodium glutamate and related compounds.
Topics: Amino Acids; Animals; Convulsants; Epilepsies, Partial; Female; Glutamates; Pentylenetetrazole; Rats | 1977 |
Role of the intracarotid amobarbital-pentylenetetrazol EEG test in the diagnosis and surgical treatment of patients with complex seizure problems.
Topics: Adolescent; Amobarbital; Brain; Carotid Arteries; Cerebrovascular Circulation; Depression, Chemical; | 1976 |
[Antiepileptic effects of nifedipine].
Topics: Animals; Anticonvulsants; Cerebral Cortex; Epilepsies, Partial; Kindling, Neurologic; Male; Nifedipi | 1991 |
Intravenous midazolam suppression of pentylenetetrazol-induced epileptogenic activity in a porcine model.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Diazepam; Electroencephalography; Ep | 1990 |
Geniculate spikes during epileptic seizures induced in dogs by pentylenetetrazol and bicuculline.
Topics: Animals; Bicuculline; Brain Stem; Dogs; Electroencephalography; Epilepsies, Partial; Evoked Potentia | 1985 |
[Effect of a Ca-channel blocker, ryodipine, on focal and generalized epileptic activity].
Topics: Animals; Calcium Channel Blockers; Epilepsies, Partial; Epilepsy; Male; Nifedipine; Pentylenetetrazo | 1989 |
[Anticonvulsive properties of enomelanin].
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroenc | 1986 |
Gustatory hallucinations in epileptic seizures. Electrophysiological, clinical and anatomical correlates.
Topics: Adult; Amygdala; Bemegride; Brain; Electric Stimulation; Electroencephalography; Epilepsies, Partial | 1987 |
Pentylenetetrazol-induced spike wave discharges in rats: a polygraphic study.
Topics: Animals; Arousal; Cerebral Cortex; Electroencephalography; Electromyography; Epilepsies, Partial; Ep | 1987 |
[Anticonvulsant properties of the cerebrospinal fluid during activation of the antiepileptic system of the brain].
Topics: Animals; Cats; Cerebellar Cortex; Electrodes, Implanted; Electroshock; Epilepsies, Partial; Epilepsy | 1988 |
Intracarotid pentylenetetrazol injections in the cat.
Topics: Acute Disease; Animals; Carotid Arteries; Cats; Chronic Disease; Electroencephalography; Epilepsies, | 1974 |
[Experimental studies of epileptic reactions. Chronic stimulations of the sensomotor cortex of the cat and the rabbit].
Topics: Adult; Aged; Aluminum; Animals; Cats; Cerebral Cortex; Child; Electrodes; Electroencephalography; Ep | 1968 |
Serum cholesterol in monkeys with chronic epileptic foci.
Topics: Animals; Cholesterol; Epilepsies, Partial; Epilepsy; Female; Haplorhini; Male; Pentylenetetrazole; S | 1971 |
The propagation of focal cortical epilepsies and its modes.
Topics: Animals; Brain; Caudate Nucleus; Cerebellum; Dogs; Electroencephalography; Electromyography; Epileps | 1971 |