pentoxifylline has been researched along with Radiation Pneumonitis in 8 studies
Radiation Pneumonitis: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Radiation pneumonitis is usually a diagnosis of exclusion." | 2.52 | Radiation induced lung injury: prediction, assessment and management. ( Giridhar, P; Julka, PK; Mallick, S; Rath, GK, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giridhar, P | 1 |
| Mallick, S | 1 |
| Rath, GK | 1 |
| Julka, PK | 1 |
| Delanian, S | 2 |
| Porcher, R | 2 |
| Balla-Mekias, S | 1 |
| Lefaix, JL | 2 |
| Osterreicher, J | 3 |
| Pejchal, J | 1 |
| Skopek, J | 3 |
| Mokrỳ, J | 2 |
| Vilasová, Z | 1 |
| Psutka, J | 1 |
| Vávrová, J | 3 |
| Mazurová, Y | 1 |
| Haddad, P | 1 |
| Kalaghchi, B | 1 |
| Amouzegar-Hashemi, F | 1 |
| Anscher, MS | 1 |
| Rudant, J | 1 |
| Navrátil, L | 2 |
| Knízek, J | 2 |
| Macela, A | 2 |
| Králik, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized, Controlled Phase Ⅱ Study of Preventively Use of Methylprednisolone After Split-course Chemoradiotherapy to Reduce the Risk of Radiation-induced Pulmonary Injury For Bulky Local Advanced None-small Cell Lung Cancer[NCT03661567] | Phase 2 | 52 participants (Actual) | Interventional | 2018-08-09 | Terminated (stopped due to slow enrollment) | ||
| Development of Radiation Fibrosis in Patients Treated With Pentoxyphylline and Vitamin E: a Prospective Randomized Study[NCT00583700] | Phase 2 | 54 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| Multicenter Prospective Evaluation of a Predictive Test of Late Toxicities After Radiotherapy by the Rate of Radiation Induced CD8 T-Lymphocyte Apoptosis: Application to Breast and Prostate Cancers.[NCT00893035] | 885 participants (Actual) | Observational | 2006-06-30 | Completed | |||
| Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy[NCT00969111] | 70 participants (Anticipated) | Interventional | 2009-08-31 | Recruiting | |||
| An Expanded Phase II Study of Hypofractionated Dose Intense Image Guided Proton Radiation Therapy for Low and Intermediate Risk Adenocarcinoma of the Prostate[NCT01368055] | 361 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | |||
| Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment[NCT03040778] | Phase 3 | 100 participants (Anticipated) | Interventional | 2018-04-01 | Enrolling by invitation | ||
| Normal Tissue Oxygenation Following Radiotherapy[NCT00677040] | 20 participants (Actual) | Observational | 2008-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A primary outcome of interest is the composite Subjective, Objective, Management, and Analytic (SOMA) score at 18-month follow-up visit. Maximum score is 45, with a score of 0 being ideal and representing no treatment-related side effects at the study visit. (NCT00583700)
Timeframe: 18 month post-treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Control Arm | 1.59 |
| Intervention: Pentoxifylline & Vitamin E | 1.0 |
"Tissue compliance meter measurements of the treated breast compared to the non-treated breast were obtained at 18 months post-radiation therapy. Tissue compliance simply means how soft and pliable the breast tissue is when force is applied to it.~One physician would hold the tissue compliance meter (TCM) against the participant's skin. A standard amount of force would be applied. A second physician would read the displacement scale for a specific set of areas on the breast. The range of the scale was 0 to 60 milimeters (mm). The physician's were blineded to the participant's intervention at the time of measurement.~The final value is the difference between the untreated and the treated breast [untreated - treated]. The range of these differences was -3.3 to 7.0 mm." (NCT00583700)
Timeframe: 18 months post-treatment
| Intervention | milimeters (mm) (Mean) |
|---|---|
| Control Arm | 2.10 |
| Intervention: Pentoxifylline & Vitamin E | 0.88 |
Transcutaneous oxygen detector is used to measure the partial pressure of oxygen. The unit detects electrolytes ionized by oxygen. The measuring electrode also heats the skin being measured to facilitate maximal bloodflow to the area. (NCT00677040)
Timeframe: One visit for 20 minutes
| Intervention | mmHg (Mean) |
|---|---|
| Subjects | 62.5 |
(NCT00677040)
Timeframe: One visit
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| late subcutaneous toxicitiy score 1 | late subcutaneous toxcity score 2 | late skin toxicity score 1 | late skin toxicity score 2 | |
| Subjects | 19 | 1 | 19 | 1 |
1 review available for pentoxifylline and Radiation Pneumonitis
| Article | Year |
|---|---|
Radiation induced lung injury: prediction, assessment and management.
Topics: Aged; Alveolar Epithelial Cells; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; | 2015 |
3 trials available for pentoxifylline and Radiation Pneumonitis
| Article | Year |
|---|---|
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli | 2003 |
Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antioxidants; Child; Female; Humans; Male; Middle Age | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina | 2005 |
4 other studies available for pentoxifylline and Radiation Pneumonitis
| Article | Year |
|---|---|
Role of type II pneumocytes in pathogenesis of radiation pneumonitis: dose response of radiation-induced lung changes in the transient high vascular permeability period.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Dexamethasone; Disease Models, Animal; Do | 2004 |
The irreversibility of radiation-induced fibrosis: fact or folklore?
Topics: Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combination; Female; Humans; Pentoxifyl | 2005 |
The alveolar septal thickness and type II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline.
Topics: Animals; Immunohistochemistry; Keratins; Lung; Male; Pentoxifylline; Pulmonary Alveoli; Radiation Pn | 2001 |
Apoptosis and bcl-2 expression in irradiated lungs and the effect of pentoxifylline.
Topics: Animals; Apoptosis; Glycoproteins; Immunohistochemistry; Lung; Male; Neutrophils; Pentoxifylline; Pr | 2001 |