pentoxifylline has been researched along with Pulmonary Fibrosis in 10 studies
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tranilast has been used in allergic diseases because of its inhibitory effect on mast cells; it also has an anti-fibrotic effect in several diseases." | 5.35 | Effects of tranilast and pentoxifylline in a mouse model of chronic asthma using house dust mite antigen. ( Ahn, JH; Kim, CH; Kim, JS; Kim, JW; Kim, SC; Kim, SJ; Kim, YH; Kim, YK; Kwon, SS; Lee, JM; Lee, SH; Lee, SY; Yoon, HK, 2009) |
| "Previous discovery that long-term administration of pentoxifylline (PTX) to mice chronically exposed to smoke led to the development of pulmonary fibrosis rather than emphysema initiated our curiosity on whether the Wnt/β-catenin pathway, a set of signaling proteins essential to organ development and lung morphogenesis in particular were activated in the pathogenesis of pulmonary fibrosis." | 3.76 | Effects of pentoxifylline on Wnt/β-catenin signaling in mice chronically exposed to cigarette smoke. ( Chen, XL; Hu, XF; Peng, MJ; Wang, XR; Wang, Z; Zhang, JN; Zhao, TT; Zou, P, 2010) |
| "Radiation pneumonitis is usually a diagnosis of exclusion." | 2.52 | Radiation induced lung injury: prediction, assessment and management. ( Giridhar, P; Julka, PK; Mallick, S; Rath, GK, 2015) |
| "The pulmonary fibrosis has no known efficient treatment." | 1.40 | The relation of radiation-induced pulmonary fibrosis with stress and the efficiency of antioxidant treatment: an experimental study. ( Bozkurt, KK; Demırpence, Ö; Doğuç, DK; Kaya, V; Şen, CA; Süren, D; Yalçın, AY; Yazkan, R; Yıldırım, M; Yüksel, Ö, 2014) |
| "Tranilast has been used in allergic diseases because of its inhibitory effect on mast cells; it also has an anti-fibrotic effect in several diseases." | 1.35 | Effects of tranilast and pentoxifylline in a mouse model of chronic asthma using house dust mite antigen. ( Ahn, JH; Kim, CH; Kim, JS; Kim, JW; Kim, SC; Kim, SJ; Kim, YH; Kim, YK; Kwon, SS; Lee, JM; Lee, SH; Lee, SY; Yoon, HK, 2009) |
| "Therapy of idiopathic pulmonary fibrosis (IPF) is directed at 1) inhibition of alveolitis and tissue damage, and 2) inhibition of matrix deposition." | 1.30 | [Pentoxifylline inhibits experimental bleomycin-induced fibrosing alveolitis]. ( Entzian, P; Gerdes, J; Gerlach, C; Schlaak, M; Zabel, P, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Finato, AC | 1 |
| Almeida, DF | 1 |
| Dos Santos, AR | 1 |
| Nascimento, DC | 1 |
| Cavalcante, RS | 1 |
| Mendes, RP | 1 |
| Soares, CT | 1 |
| Paniago, AMM | 1 |
| Venturini, J | 1 |
| Kaya, V | 1 |
| Yazkan, R | 1 |
| Yıldırım, M | 1 |
| Doğuç, DK | 1 |
| Süren, D | 1 |
| Bozkurt, KK | 1 |
| Yüksel, Ö | 1 |
| Demırpence, Ö | 1 |
| Şen, CA | 1 |
| Yalçın, AY | 1 |
| Giridhar, P | 1 |
| Mallick, S | 1 |
| Rath, GK | 1 |
| Julka, PK | 1 |
| Kim, SJ | 1 |
| Kim, JW | 1 |
| Kim, YH | 1 |
| Lee, SH | 1 |
| Yoon, HK | 1 |
| Kim, CH | 1 |
| Ahn, JH | 1 |
| Lee, JM | 1 |
| Kim, JS | 1 |
| Kim, SC | 1 |
| Lee, SY | 1 |
| Kwon, SS | 1 |
| Kim, YK | 1 |
| Naranjo, TW | 1 |
| Lopera, DE | 1 |
| Diaz-Granados, LR | 1 |
| Duque, JJ | 1 |
| Restrepo, AM | 1 |
| Cano, LE | 1 |
| Wang, Z | 1 |
| Zhang, JN | 1 |
| Hu, XF | 1 |
| Chen, XL | 1 |
| Wang, XR | 1 |
| Zhao, TT | 1 |
| Peng, MJ | 1 |
| Zou, P | 1 |
| Entzian, P | 2 |
| Gerlach, C | 2 |
| Gerdes, J | 1 |
| Schlaak, M | 2 |
| Zabel, P | 2 |
| Zähringer, U | 1 |
| Galle, J | 1 |
| Delanian, S | 1 |
| Balla-Mekias, S | 1 |
| Lefaix, JL | 1 |
| Kremer, S | 1 |
| Breuer, R | 1 |
| Lossos, IS | 1 |
| Berkman, N | 1 |
| Christensen, TG | 1 |
| Connor, MW | 1 |
| Goldstein, RH | 1 |
| Or, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized, Controlled Phase Ⅱ Study of Preventively Use of Methylprednisolone After Split-course Chemoradiotherapy to Reduce the Risk of Radiation-induced Pulmonary Injury For Bulky Local Advanced None-small Cell Lung Cancer[NCT03661567] | Phase 2 | 52 participants (Actual) | Interventional | 2018-08-09 | Terminated (stopped due to slow enrollment) | ||
| Development of Radiation Fibrosis in Patients Treated With Pentoxyphylline and Vitamin E: a Prospective Randomized Study[NCT00583700] | Phase 2 | 54 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| Multicenter Prospective Evaluation of a Predictive Test of Late Toxicities After Radiotherapy by the Rate of Radiation Induced CD8 T-Lymphocyte Apoptosis: Application to Breast and Prostate Cancers.[NCT00893035] | 885 participants (Actual) | Observational | 2006-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A primary outcome of interest is the composite Subjective, Objective, Management, and Analytic (SOMA) score at 18-month follow-up visit. Maximum score is 45, with a score of 0 being ideal and representing no treatment-related side effects at the study visit. (NCT00583700)
Timeframe: 18 month post-treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Control Arm | 1.59 |
| Intervention: Pentoxifylline & Vitamin E | 1.0 |
"Tissue compliance meter measurements of the treated breast compared to the non-treated breast were obtained at 18 months post-radiation therapy. Tissue compliance simply means how soft and pliable the breast tissue is when force is applied to it.~One physician would hold the tissue compliance meter (TCM) against the participant's skin. A standard amount of force would be applied. A second physician would read the displacement scale for a specific set of areas on the breast. The range of the scale was 0 to 60 milimeters (mm). The physician's were blineded to the participant's intervention at the time of measurement.~The final value is the difference between the untreated and the treated breast [untreated - treated]. The range of these differences was -3.3 to 7.0 mm." (NCT00583700)
Timeframe: 18 months post-treatment
| Intervention | milimeters (mm) (Mean) |
|---|---|
| Control Arm | 2.10 |
| Intervention: Pentoxifylline & Vitamin E | 0.88 |
1 review available for pentoxifylline and Pulmonary Fibrosis
| Article | Year |
|---|---|
Radiation induced lung injury: prediction, assessment and management.
Topics: Aged; Alveolar Epithelial Cells; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; | 2015 |
9 other studies available for pentoxifylline and Pulmonary Fibrosis
| Article | Year |
|---|---|
Evaluation of antifibrotic and antifungal combined therapies in experimental pulmonary paracoccidioidomycosis.
Topics: Animals; Antifungal Agents; Azithromycin; Cytokines; Disease Models, Animal; Drug Therapy, Combinati | 2020 |
The relation of radiation-induced pulmonary fibrosis with stress and the efficiency of antioxidant treatment: an experimental study.
Topics: Animals; Antioxidants; Ascorbic Acid; Histological Techniques; Pentoxifylline; Pulmonary Fibrosis; R | 2014 |
Effects of tranilast and pentoxifylline in a mouse model of chronic asthma using house dust mite antigen.
Topics: Animals; Anti-Allergic Agents; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronch | 2009 |
Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice.
Topics: Animals; Antifungal Agents; Collagen; Cytokines; Drug Therapy, Combination; Immunologic Factors; Itr | 2011 |
Effects of pentoxifylline on Wnt/β-catenin signaling in mice chronically exposed to cigarette smoke.
Topics: Animals; beta Catenin; Blotting, Western; Female; Immunohistochemistry; Mice; Mice, Inbred BALB C; P | 2010 |
[Pentoxifylline inhibits experimental bleomycin-induced fibrosing alveolitis].
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Male; Pentoxifylline; Phosphodiesterase Inhibitors; | 1997 |
Comparative study on effects of pentoxifylline, prednisolone and colchicine in experimental alveolitis.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Body Weight; Bronchoalveolar Lavage Fluid | 1998 |
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol.
Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; M | 1999 |
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol.
Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; M | 1999 |
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol.
Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; M | 1999 |
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol.
Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; M | 1999 |
Effect of immunomodulators on bleomycin-induced lung injury.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Bleomycin; Hydroxyquinolines; Male; Mi | 1999 |