Page last updated: 2024-11-02

pentoxifylline and Pregnancy

pentoxifylline has been researched along with Pregnancy in 69 studies

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Using Pentoxifylline in pregnancy affected by FGR might show promising effects."9.51Effectiveness of pentoxifylline in severe early-onset fetal growth restriction: A randomized double-blinded clinical trial. ( Abdi, N; Alamdarloo, SM; Asadi, N; Asmarian, N; Bazrafshan, K; Faraji, A; Gharibpour, F; Izze, S; Jamshidzadeh, A; Kasraeian, M; Mokhtar Pour, A; Roozmeh, S; Shiravani, Z; Vafaei, H, 2022)
"Among 98 patients finally considered in the evaluation of the results, the 6 month overall pregnancy rates were 28 and 14% in the pentoxifylline and placebo groups, respectively."9.13Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial. ( Balasch, J; Carmona, F; Creus, M; del Pino, M; Fábregues, F; Manau, D, 2008)
" Due to the very limited evidence, we are uncertain of the effects of pentoxifylline on clinical pregnancy rate, miscarriage rate, or overall pain."9.12Pentoxifylline for the treatment of endometriosis-associated pain and infertility. ( Becker, CM; Georgiou, EX; Grammatis, AL, 2021)
"To study the effect of pentoxifylline on sperm motility, oocyte fertilization, embryo cleavage, and quality as well as pregnancy outcome on asthenospermic patients participating in an IVF program."9.08The effect of pentoxifylline on sperm motility, oocyte fertilization, embryo quality, and pregnancy outcome in an in vitro fertilization program. ( Arvaniti, K; Dimitriadou, F; Kanakas, N; Mantzavinos, T; Prapa, A; Rizos, D; Voutsina, K, 1995)
"The present study is the first prospective randomized controlled trial of the effect of pentoxifylline on future fertility in infertile women with asymptomatic minimal or mild endometriosis."9.08Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial. ( Balasch, J; Carmona, F; Creus, M; Fábregues, F; Manau, D; Martínez-Román, S; Vanrell, JA, 1997)
"To assess the effects of pentoxifylline, which has anti-inflammatory effects, in subfertile, premenopausal women for the management of endometriosis."8.88Pentoxifylline for endometriosis. ( Clarke, J; Li, Y; Lu, D; Shi, G; Song, H, 2012)
"To determine the effectiveness and safety of pentoxifylline, which has anti-inflammatory effects, in the management of endometriosis in subfertile, premenopausal women."8.85Pentoxifylline versus medical therapies for subfertile women with endometriosis. ( Clarke, J; Li, Y; Lv, D; Shi, G; Song, H, 2009)
"The aim of this study was to assess the consequences of treatment with pentoxifylline (PTX), an inducer of sperm motility, on sperm DNA fragmentation (SDF) and clinical characteristics in non-obstructive azoospermia (NOA) patients."8.31Pentoxifylline treatment had no detrimental effect on sperm DNA integrity and clinical characteristics in cases with non-obstructive azoospermia. ( Anbari, F; Khalili, MA; Mahaldashtian, M; Mangoli, E; Zavereh, S, 2023)
"Recently pentoxifylline, a non-selective phosphodiesterase inhibitor and adenosine receptor antagonist, has attracted much interest for the treatment of the increased vascular resistance and endothelial dysfunction in pre-eclampsia."8.12Pentoxifylline as a therapeutic option for pre-eclampsia: a study on its placental effects. ( Broekhuizen, M; Danser, AHJ; de Vries, R; Dik, WA; Hitzerd, E; Koch, BCP; Merkus, D; Reiss, IKM; Schoenmakers, S; Simons, SHP; Smits, MAW, 2022)
" Since Pentoxifylline, a methyl-xanthine derivative known for enhancement of vascular endothelial function, down-regulation of many inflammatory cytokines increased during preeclampsia, improvement of placental circulation, reduction of ischemia-reperfusion injury, enhancement of vasodilatation and endothelial function, ameliorating proteinuria, inhibition of platelet aggregation and decreasing risk of preterm labor, which are all amongst morbidities of preeclampsia, here it is hypothesized that Pentoxifylline prevents development of preeclampsia and/or decelerate progression of the disease."7.81Hypothesis: Pentoxifylline explores new horizons in treatment of preeclampsia. ( Azimi, A; Farhadi, P; Sagheb, MM; Ziaee, SM, 2015)
"Pentoxifylline (PF) has been used to enhance sperm motility in many in vitro fertilization programs."6.69Pentoxifylline initiates motility in spontaneously immotile epididymal and testicular spermatozoa and allows normal fertilization, pregnancy, and birth after intracytoplasmic sperm injection. ( Giorgetti, C; Hans, E; Roulier, R; Salzmann, J; Spach, JL; Terriou, P; Urrutia, V, 2000)
"Primary ciliary dyskinesia (PCD), previously known as immotile cilia syndrome, can cause respiratory and reproductive problems."6.45Can pentoxifylline improve the sperm motion and ICSI success in the primary ciliary dyskinesia? ( Akcin, O; Attar, R; Ficicioglu, C; Tecellioglu, N; Yencilek, F; Yildirim, G, 2009)
"Using Pentoxifylline in pregnancy affected by FGR might show promising effects."5.51Effectiveness of pentoxifylline in severe early-onset fetal growth restriction: A randomized double-blinded clinical trial. ( Abdi, N; Alamdarloo, SM; Asadi, N; Asmarian, N; Bazrafshan, K; Faraji, A; Gharibpour, F; Izze, S; Jamshidzadeh, A; Kasraeian, M; Mokhtar Pour, A; Roozmeh, S; Shiravani, Z; Vafaei, H, 2022)
"Among 98 patients finally considered in the evaluation of the results, the 6 month overall pregnancy rates were 28 and 14% in the pentoxifylline and placebo groups, respectively."5.13Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial. ( Balasch, J; Carmona, F; Creus, M; del Pino, M; Fábregues, F; Manau, D, 2008)
" Due to the very limited evidence, we are uncertain of the effects of pentoxifylline on clinical pregnancy rate, miscarriage rate, or overall pain."5.12Pentoxifylline for the treatment of endometriosis-associated pain and infertility. ( Becker, CM; Georgiou, EX; Grammatis, AL, 2021)
"The present study is the first prospective randomized controlled trial of the effect of pentoxifylline on future fertility in infertile women with asymptomatic minimal or mild endometriosis."5.08Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial. ( Balasch, J; Carmona, F; Creus, M; Fábregues, F; Manau, D; Martínez-Román, S; Vanrell, JA, 1997)
"To assess the effects of pentoxifylline, which has anti-inflammatory effects, in subfertile, premenopausal women for the management of endometriosis."4.88Pentoxifylline for endometriosis. ( Clarke, J; Li, Y; Lu, D; Shi, G; Song, H, 2012)
"To determine the effectiveness and safety of pentoxifylline, which has anti-inflammatory effects, in the management of endometriosis in subfertile, premenopausal women."4.85Pentoxifylline versus medical therapies for subfertile women with endometriosis. ( Clarke, J; Li, Y; Lv, D; Shi, G; Song, H, 2009)
"The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate."4.84Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007)
"The aim of this study was to assess the consequences of treatment with pentoxifylline (PTX), an inducer of sperm motility, on sperm DNA fragmentation (SDF) and clinical characteristics in non-obstructive azoospermia (NOA) patients."4.31Pentoxifylline treatment had no detrimental effect on sperm DNA integrity and clinical characteristics in cases with non-obstructive azoospermia. ( Anbari, F; Khalili, MA; Mahaldashtian, M; Mangoli, E; Zavereh, S, 2023)
"This study aims to investigate if the administration of pentoxifylline during ovarian stimulation have an impact on the quantity and quality of oocytes recovered for in vitro fertilization (IVF), the quality of zygotes and embryos resulting from IVF, the serum estradiol and progesterone concentrations, the endometrial thickness and pregnancy outcomes after embryo transfer."4.12Use of pentoxifylline during ovarian stimulation to improve oocyte and embryo quality: A retrospective study. ( Carugno, J; Conde-López, C; Mendoza, N; Mendoza-Tesarik, R; Palumbo, M; Rapisarda, AMC; Tesarik, J; Vitale, SG, 2022)
"Recently pentoxifylline, a non-selective phosphodiesterase inhibitor and adenosine receptor antagonist, has attracted much interest for the treatment of the increased vascular resistance and endothelial dysfunction in pre-eclampsia."4.12Pentoxifylline as a therapeutic option for pre-eclampsia: a study on its placental effects. ( Broekhuizen, M; Danser, AHJ; de Vries, R; Dik, WA; Hitzerd, E; Koch, BCP; Merkus, D; Reiss, IKM; Schoenmakers, S; Simons, SHP; Smits, MAW, 2022)
" Since Pentoxifylline, a methyl-xanthine derivative known for enhancement of vascular endothelial function, down-regulation of many inflammatory cytokines increased during preeclampsia, improvement of placental circulation, reduction of ischemia-reperfusion injury, enhancement of vasodilatation and endothelial function, ameliorating proteinuria, inhibition of platelet aggregation and decreasing risk of preterm labor, which are all amongst morbidities of preeclampsia, here it is hypothesized that Pentoxifylline prevents development of preeclampsia and/or decelerate progression of the disease."3.81Hypothesis: Pentoxifylline explores new horizons in treatment of preeclampsia. ( Azimi, A; Farhadi, P; Sagheb, MM; Ziaee, SM, 2015)
"To compare fertilization, cleavage, and pregnancy outcome using pentoxifylline and a hypoosmotic swelling (HOS) test to select viable spermatozoa from testicular biopsy specimens."3.77Selection of viable spermatozoa from testicular biopsies: a comparative study between pentoxifylline and hypoosmotic swelling test. ( Dandekar, S; Desai, S; Mangoli, R; Mangoli, V; Suri, K, 2011)
"With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome."3.77Birth of a healthy infant after intracytoplasmic sperm injection using pentoxifylline-activated sperm from a patient with Kartagener's syndrome. ( Hattori, H; Ito, C; Kyono, K; Nakajo, Y; Toshimori, K; Toyama, Y, 2011)
"The objective was to determine if long-term treatment with trimethoprim sulfamethoxazole (antimicrobial), pentoxifylline (anti-inflammatory/anti-cytokine) and altrenogest (synthetic progestin), would improve pregnancy outcome in mares with experimentally induced placentitis."3.76Treatment efficacy of trimethoprim sulfamethoxazole, pentoxifylline and altrenogest in experimentally induced equine placentitis. ( Bailey, CS; Benson, S; Giguere, S; Leblanc, MM; Macpherson, ML; Pozor, MA; Sanchez, LC; Troedsson, MH; Vickroy, TW, 2010)
" The aim of this study was to determine the adverse effects of maternal nicotine exposure during pregnancy and lactation on neonatal rat bone development, and to determine a protective effect of pentoxifylline (PTX)."3.74Influence of maternal nicotine exposure on neonatal rat bone: protective effect of pentoxifylline. ( Bastug, F; Bastug, O; Canoz, O; Gunes, I; Gunes, T; Koklu, E; Kula, M; Kurtoglu, S, 2007)
"Our objective was to determine whether two methylxanthines, pentoxifylline (PTX) and allopurinol, would have beneficial effects on experimental pregnancy-induced pre-eclampsia- like disease in ewes."3.71Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes. ( Németh, I; Pintér, S; Tálosi, G, 2001)
"Pentoxifylline was given as a supplement to standard tocolytic therapy in a group of 43 patients (pentoxifylline group) as an intravenous infusion and oral supplementation in a total dosage of 800 mg/day."2.77Effect of pentoxifylline, administered in preterm labour, on the foetal-placental circulation and neonatal outcome: a randomized, prospective pilot study. ( Bręborowicz, G; Hurkała, J; Lauterbach, R; Pawlik, D; Rytlewski, K; Szymankiewicz, M; Wójtowicz, A, 2012)
"Treatment with pentoxifylline (P = 0."2.70The addition of pentoxifylline to conventional therapy improves outcome in patients with peripartum cardiomyopathy. ( Bergemann, A; Candy, G; Hopley, M; Sareli, P; Skudicky, D; Sliwa, K, 2002)
"Neonatal sepsis is the cause of substantial morbidity and mortality."2.55Neonatal sepsis. ( Sánchez, PJ; Shane, AL; Stoll, BJ, 2017)
"Primary ciliary dyskinesia (PCD), previously known as immotile cilia syndrome, can cause respiratory and reproductive problems."2.45Can pentoxifylline improve the sperm motion and ICSI success in the primary ciliary dyskinesia? ( Akcin, O; Attar, R; Ficicioglu, C; Tecellioglu, N; Yencilek, F; Yildirim, G, 2009)
"Pentoxifylline (PTX) is a non-specific phosphodiesterase inhibitor which raises intracellular cyclic adenosine monophosphate and decreases production of pro-inflammatory mediators while enhancing anti-inflammatory cytokines."1.46Pentoxifylline inhibits lipopolysaccharide-induced inflammatory mediators in human second trimester placenta explants. ( Hanna, N; Hou, W; Islam, S; Lin, X; Murthy, A; Speer, EM, 2017)
"Antiphospholipid antibody syndrome is an autoimmune disorder associated with pregnancy complications, venous and/or arterial thrombosis and the presence of antiphospholipid antibodies."1.42Reactive angioendotheliomatosis as a presenting cutaneous manifestation of Hughes syndrome. ( Jamale, V; Kale, M; Nikam, B; Shah, S, 2015)

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-19904 (5.80)18.7374
1990's19 (27.54)18.2507
2000's14 (20.29)29.6817
2010's24 (34.78)24.3611
2020's8 (11.59)2.80

Authors

AuthorsStudies
Vitale, SG1
Palumbo, M1
Rapisarda, AMC1
Carugno, J1
Conde-López, C1
Mendoza, N1
Mendoza-Tesarik, R1
Tesarik, J1
de Oliveira, JS1
Silva, AADN1
Dias, FCR1
de Oliveira, EL1
de Oliveira Filho, EF1
Soares, PC1
Ferreira, CMO1
da Silva Junior, VA1
Asadi, N1
Roozmeh, S1
Vafaei, H1
Asmarian, N1
Jamshidzadeh, A1
Bazrafshan, K1
Kasraeian, M1
Faraji, A1
Shiravani, Z1
Mokhtar Pour, A1
Alamdarloo, SM1
Abdi, N1
Gharibpour, F1
Izze, S1
Broekhuizen, M1
de Vries, R1
Smits, MAW1
Dik, WA1
Schoenmakers, S1
Koch, BCP1
Merkus, D1
Reiss, IKM1
Danser, AHJ1
Simons, SHP1
Hitzerd, E1
Mahaldashtian, M1
Khalili, MA1
Mangoli, E1
Zavereh, S1
Anbari, F1
Krief, F1
Simon, C1
Goldstein, R1
Ellenberg, LP1
Ledee, N1
Wang, XF1
Li, JD1
Huo, YL1
Zhang, YP1
Fang, ZQ1
Wang, HP1
Peng, W1
Johnson, AK1
Xue, B1
Grammatis, AL1
Georgiou, EX1
Becker, CM1
Shane, AL1
Sánchez, PJ1
Stoll, BJ1
Speer, EM2
Lin, X1
Murthy, A1
Hou, W1
Islam, S1
Hanna, N1
Ozkavukcu, S1
Celik-Ozenci, C1
Konuk, E1
Atabekoglu, C1
Dowling, DJ1
Xu, J1
Ozog, LS1
Mathew, JA1
Chander, A1
Yin, D1
Levy, O1
Papagianis, PC1
Pillow, JJ1
Moss, TJ1
Salian, SR1
Nayak, G1
Kumari, S1
Patel, S1
Gowda, S1
Shenoy, Y1
Sugunan, S1
G K, R1
Managuli, RS1
Mutalik, S1
Dahiya, V1
Pal, S1
Adiga, SK1
Kalthur, G1
Rota, A1
Sabatini, C1
Przybył, A1
Ciaramelli, A1
Panzani, D1
Camillo, F1
Dilek, M1
Kumral, A1
Okyay, E1
Ozbal, S1
Tugyan, K1
Tuzun, F1
Sever, AH1
Yilmaz, O1
Duman, N1
Ozkan, H1
Chen, SS1
Block, BS1
Chan, PJ1
Goksan Pabuccu, E1
Sinem Caglar, G1
Dogus Demirkiran, O1
Pabuccu, R1
Desplantie, O1
Tremblay-Gravel, M1
Avram, R1
Marquis-Gravel, G1
Ducharme, A1
Jolicoeur, EM1
Cardona-Guarache, R1
Kron, J1
Azimi, A1
Ziaee, SM1
Farhadi, P1
Sagheb, MM1
Nikam, B1
Shah, S1
Kale, M1
Jamale, V1
Alijotas-Reig, J1
Esteve-Valverde, E1
Ferrer-Oliveras, R1
Llurba, E1
Gris, JM1
Navas, P1
Paffoni, A1
Intra, G1
González-Utor, A1
Clavero, A1
Gonzalvo, MC1
Díaz, R1
Peña, R1
Restelli, L1
Somigliana, E1
Papaleo, E1
Castilla, JA1
Viganò, P1
Lv, D1
Song, H2
Li, Y2
Clarke, J2
Shi, G2
Bailey, CS2
Macpherson, ML1
Pozor, MA2
Troedsson, MH1
Benson, S1
Giguere, S1
Sanchez, LC1
Leblanc, MM1
Vickroy, TW1
Mangoli, V1
Mangoli, R1
Dandekar, S1
Suri, K1
Desai, S1
Malpani, A2
Hattori, H1
Nakajo, Y1
Ito, C1
Toyama, Y1
Toshimori, K1
Kyono, K1
Sper, RB1
Schewmaker, JL1
Buchanan, CN1
Beachler, TM1
Whitacre, MD1
Lauterbach, R1
Rytlewski, K1
Pawlik, D1
Hurkała, J1
Wójtowicz, A1
Bręborowicz, G1
Szymankiewicz, M1
Lu, D1
Almario, B1
Wu, S1
Peng, J1
Alapati, D1
Chen, S1
Sosenko, IR1
Patole, S1
Vijayakumar, P1
Jog, S1
Giorgetti, C2
Chinchole, JM1
Hans, E2
Charles, O1
Franquebalme, JP1
Glowaczower, E1
Salzmann, J2
Terriou, P2
Roulier, R2
Griveau, JF1
Lobel, B1
Laurent, MC1
Michardière, L1
Le Lannou, D1
Badgwell, C1
Rosen, T1
Kurtoglu, S1
Gunes, T1
Koklu, E1
Bastug, O1
Canoz, O1
Kula, M1
Bastug, F1
Gunes, I1
Yildirim, G1
Ficicioglu, C1
Akcin, O1
Attar, R1
Tecellioglu, N1
Yencilek, F1
Creus, M2
Fábregues, F2
Carmona, F2
del Pino, M1
Manau, D2
Balasch, J2
Gubskiĭ, IuI1
Radzinskiĭ, VE1
Smal'ko, PIa1
Korniushina, TV1
Kavraĭskaia, IA1
Nazarova, LA3
Chaouat, G2
Assal Meliani, A1
Martal, J1
Raghupathy, R1
Elliott, JF1
Elliot, J1
Mosmann, T1
Wegmann, TG1
Johnston, RC1
Mbizvo, MT1
Summerbell, D1
Kovacs, GT1
Baker, HW1
Dimitriadou, F1
Rizos, D1
Mantzavinos, T1
Arvaniti, K1
Voutsina, K1
Prapa, A1
Kanakas, N1
Ramey, JW1
Starke, ME1
Gibbons, WE1
Archer, DF1
Tournaye, H1
Van der Linden, M1
Van den Abbeel, E1
Devroey, P1
Van Steirteghem, A1
Edirisinghe, WR2
Junk, S1
Yovich, JM3
Bootsma, B1
Yovich, JL3
Fountain, S2
Rizk, B2
Avery, S2
Palmer, C2
Blayney, M2
Macnamee, M2
Mills, C2
Brinsden, P2
Maxwell, WM1
Robinson, SJ1
Roca, J1
Molinia, FC1
Sánchez-Partida, LG1
Evans, G1
Wittemer, C1
Ohl, J1
Bettahar-Lebugle, K1
Moreau, L1
Dellenbach, P1
Martínez-Román, S1
Vanrell, JA1
Sulkowska, M1
Ain, R1
Seshagiri, PB1
Spach, JL1
Urrutia, V1
Strizhakov, AN1
Musaev, ZM1
Timokhina, TF1
Tálosi, G1
Németh, I1
Pintér, S1
Petrova, OP1
Konstantinova, NN1
Lédée-Bataille, N1
Olivennes, F1
Lefaix, JL1
Frydman, R1
Delanian, S1
Sliwa, K1
Skudicky, D1
Candy, G1
Bergemann, A1
Hopley, M1
Sareli, P1
Pchelkina, IB1
Momot, AP1
Cummins, JM2
Gendron, RL1
Nestel, FP1
Lapp, WS1
Baines, MG1
Jequier, AM1
Gearon, C1
Apted, SL1
Karymshakova, KK1
Kucheriavenko, AN2

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect Of Using Oxygen On The Diaper Dermatitis In Infants[NCT05427760]103 participants (Actual)Interventional2022-10-15Completed
Safely Reduce Newborn Antibiotic Exposure With the Early-onset Sepsis Calculator: a Cluster Randomized Study (EOS Calculator RCT)[NCT05274776]1,830 participants (Anticipated)Interventional2022-04-12Recruiting
Gastroesophageal Reflux Poses a Potential Risk for Late Complications of BPD: A Prospective Study[NCT03014453]187 participants (Actual)Observational2017-01-09Completed
Combined Laparoscopic Surgery and Pentoxifylline Therapy for Treatment of Endometriosis-Associated Infertility: A Preliminary Study[NCT00632697]Phase 3104 participants (Actual)Interventional2001-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

the Late Complications of BPD Infants

In all patients, complications were evaluated via questionnaires at 3, 6, 9 and 12 months corrected for premature age, including respiratory symptoms (including home respiratory support, respiratory medication administration, cough without cold at least once per week, re-hospitalization due to respiratory diseases), vomiting when feeding, hypoxic ischemic injury, retinopathy of prematurity, rehospitalization and sudden death. (NCT03014453)
Timeframe: 18 months

InterventionParticipants (Count of Participants)
respiratory symptomsVomiting when feedingretinopathy of prematurityhypoxic ischemic injurysudden infant death syndromerehospitalization
Extremely Premature Infants With Bronchopulmonary Dysplasia5745304131

Reviews

11 reviews available for pentoxifylline and Pregnancy

ArticleYear
Histomorphometric and oxidative evaluation of the offspring's testis from type 2 diabetic female rats treated with metformin and pentoxifylline.
    International journal of experimental pathology, 2022, Volume: 103, Issue:5

    Topics: Animals; Diabetes Mellitus, Type 2; Female; Lipid Peroxidation; Male; Metformin; Oxidative Stress; P

2022
Pentoxifylline for the treatment of endometriosis-associated pain and infertility.
    The Cochrane database of systematic reviews, 2021, 08-25, Volume: 8

    Topics: Endometriosis; Female; Humans; Infertility, Female; Live Birth; Pain; Pentoxifylline; Pregnancy; Pre

2021
Neonatal sepsis.
    Lancet (London, England), 2017, Oct-14, Volume: 390, Issue:10104

    Topics: Algorithms; Anti-Infective Agents; Blood Component Transfusion; Chorioamnionitis; Cross Infection; F

2017
Neonatal sepsis.
    Lancet (London, England), 2017, Oct-14, Volume: 390, Issue:10104

    Topics: Algorithms; Anti-Infective Agents; Blood Component Transfusion; Chorioamnionitis; Cross Infection; F

2017
Neonatal sepsis.
    Lancet (London, England), 2017, Oct-14, Volume: 390, Issue:10104

    Topics: Algorithms; Anti-Infective Agents; Blood Component Transfusion; Chorioamnionitis; Cross Infection; F

2017
Neonatal sepsis.
    Lancet (London, England), 2017, Oct-14, Volume: 390, Issue:10104

    Topics: Algorithms; Anti-Infective Agents; Blood Component Transfusion; Chorioamnionitis; Cross Infection; F

2017
Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies.
    Paediatric respiratory reviews, 2019, Volume: 30

    Topics: Anti-Inflammatory Agents; Bronchopulmonary Dysplasia; Chorioamnionitis; Dexamethasone; Female; Fetal

2019
The Medical Treatment of New-Onset Peripartum Cardiomyopathy: A Systematic Review of Prospective Studies.
    The Canadian journal of cardiology, 2015, Volume: 31, Issue:12

    Topics: Bromocriptine; Cardiomyopathies; Echocardiography; Female; Humans; Hydrazones; Pentoxifylline; Pregn

2015
Tumor Necrosis Factor-Alpha and Pregnancy: Focus on Biologics. An Updated and Comprehensive Review.
    Clinical reviews in allergy & immunology, 2017, Volume: 53, Issue:1

    Topics: Abortion, Habitual; Antimalarials; Biological Products; Cytokines; Embryo Implantation; Female; Fert

2017
Pentoxifylline versus medical therapies for subfertile women with endometriosis.
    The Cochrane database of systematic reviews, 2009, Jul-08, Issue:3

    Topics: Endometriosis; Female; Humans; Immunologic Factors; Infertility, Female; Pentoxifylline; Pregnancy;

2009
Pentoxifylline for endometriosis.
    The Cochrane database of systematic reviews, 2012, Jan-18, Volume: 1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Endometriosis; Female; Humans; Immunologic

2012
Perinatal immunomodulation.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2002, Volume: 11, Issue:5

    Topics: Adjuvants, Immunologic; Chronic Disease; Cromolyn Sodium; Female; Glucocorticoids; Hematopoietic Cel

2002
Cutaneous sarcoidosis therapy updated.
    Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:1

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents

2007
Can pentoxifylline improve the sperm motion and ICSI success in the primary ciliary dyskinesia?
    Archives of gynecology and obstetrics, 2009, Volume: 279, Issue:2

    Topics: Adult; Ciliary Motility Disorders; Female; Humans; Infertility, Male; Male; Pentoxifylline; Pregnanc

2009

Trials

14 trials available for pentoxifylline and Pregnancy

ArticleYear
Effectiveness of pentoxifylline in severe early-onset fetal growth restriction: A randomized double-blinded clinical trial.
    Taiwanese journal of obstetrics & gynecology, 2022, Volume: 61, Issue:4

    Topics: Antioxidants; Female; Fetal Growth Retardation; Fetal Weight; Humans; Infant; Infant, Newborn; Pento

2022
Effect of pentoxifylline, administered in preterm labour, on the foetal-placental circulation and neonatal outcome: a randomized, prospective pilot study.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 110, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Drug Therapy, Combination; Female; Fetus; Humans; Infant, N

2012
Crude cumulative delivery rate following ICSI using intentionally frozen-thawed testicular spermatozoa in 51 men with non-obstructive azoospermia.
    Reproductive biomedicine online, 2005, Volume: 11, Issue:3

    Topics: Adult; Cryopreservation; Delivery, Obstetric; Female; Humans; Male; Middle Aged; Oligospermia; Pento

2005
Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:8

    Topics: Adult; Combined Modality Therapy; Endometriosis; Female; Humans; Immunologic Factors; Infertility, F

2008
Relationship between stimulated hyperactivated motility of human spermatozoa and pregnancy rate in donor insemination: a preliminary report.
    Human reproduction (Oxford, England), 1994, Volume: 9, Issue:9

    Topics: Cryopreservation; Female; Humans; In Vitro Techniques; Infertility, Male; Insemination, Artificial,

1994
The effect of pentoxifylline on sperm motility, oocyte fertilization, embryo quality, and pregnancy outcome in an in vitro fertilization program.
    Fertility and sterility, 1995, Volume: 63, Issue:4

    Topics: Cleavage Stage, Ovum; Embryo, Mammalian; Female; Fertilization; Fertilization in Vitro; Humans; Male

1995
Sperm stimulants can improve fertilization rates in male-factor cases undergoing IVF to the same extent as micromanipulation by partial zona dissection (PZD) or subzonal sperm insemination (SUZI): a randomized controlled study.
    Journal of assisted reproduction and genetics, 1995, Volume: 12, Issue:5

    Topics: Deoxyadenosines; Female; Fertilization in Vitro; Humans; Infertility, Male; Insemination, Artificial

1995
An evaluation of the effect of pentoxifylline on sperm function and treatment outcome of male-factor infertility: a preliminary study.
    Journal of assisted reproduction and genetics, 1995, Volume: 12, Issue:10

    Topics: Adult; Embryo Transfer; Female; Fertilization; Fertilization in Vitro; Humans; Infertility, Male; Ma

1995
Successful use of pentoxifylline in male-factor infertility and previous failure of in vitro fertilization: a prospective randomized study.
    Journal of assisted reproduction and genetics, 1995, Volume: 12, Issue:10

    Topics: Adult; Female; Fertilization; Fertilization in Vitro; Humans; Infertility, Male; Male; Pentoxifyllin

1995
Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial.
    Human reproduction (Oxford, England), 1997, Volume: 12, Issue:9

    Topics: Adjuvants, Immunologic; Endometriosis; Female; Humans; Infertility; Pentoxifylline; Pilot Projects;

1997
Pentoxifylline initiates motility in spontaneously immotile epididymal and testicular spermatozoa and allows normal fertilization, pregnancy, and birth after intracytoplasmic sperm injection.
    Journal of assisted reproduction and genetics, 2000, Volume: 17, Issue:4

    Topics: Adult; Embryo, Mammalian; Embryonic and Fetal Development; Epididymis; Female; Humans; Male; Pentoxi

2000
Combined treatment by pentoxifylline and tocopherol for recipient women with a thin endometrium enrolled in an oocyte donation programme.
    Human reproduction (Oxford, England), 2002, Volume: 17, Issue:5

    Topics: Adult; Birth Rate; Drug Therapy, Combination; Endometrium; Female; Fibrosis; Humans; Oocyte Donation

2002
The addition of pentoxifylline to conventional therapy improves outcome in patients with peripartum cardiomyopathy.
    European journal of heart failure, 2002, Volume: 4, Issue:3

    Topics: Adult; Cardiomyopathies; Cardiotonic Agents; Enzyme Inhibitors; Female; Humans; Pentoxifylline; Preg

2002
Influence of pentoxifylline in severe male factor infertility.
    Fertility and sterility, 1990, Volume: 53, Issue:4

    Topics: Clinical Trials as Topic; Embryo Transfer; Female; Fertilization; Humans; Infertility, Male; Male; O

1990

Other Studies

44 other studies available for pentoxifylline and Pregnancy

ArticleYear
Use of pentoxifylline during ovarian stimulation to improve oocyte and embryo quality: A retrospective study.
    Journal of gynecology obstetrics and human reproduction, 2022, Volume: 51, Issue:6

    Topics: Cross-Over Studies; Estradiol; Female; Humans; Oocytes; Ovulation Induction; Pentoxifylline; Pregnan

2022
Pentoxifylline as a therapeutic option for pre-eclampsia: a study on its placental effects.
    British journal of pharmacology, 2022, Volume: 179, Issue:22

    Topics: Adenosine; Anti-Inflammatory Agents; Cyclic GMP; Female; Humans; Nitric Oxide Synthase; Pentoxifylli

2022
Pentoxifylline treatment had no detrimental effect on sperm DNA integrity and clinical characteristics in cases with non-obstructive azoospermia.
    Zygote (Cambridge, England), 2023, Volume: 31, Issue:1

    Topics: Azoospermia; DNA; Female; Humans; Male; Pentoxifylline; Pilot Projects; Pregnancy; Pregnancy Rate; R

2023
Efficacy of tocopherol and pentoxifylline combined therapy for women undergoing assisted reproductive treatment with poor endometrial development: a retrospective cohort study on 143 patients.
    Human fertility (Cambridge, England), 2021, Volume: 24, Issue:5

    Topics: Endometrium; Female; Fertilization in Vitro; Humans; Pentoxifylline; Pregnancy; Pregnancy Rate; Pros

2021
Blockade of angiotensin-converting enzyme or tumor necrosis factor-α reverses maternal high-fat diet-induced sensitization of angiotensin II hypertension in male rat offspring.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2020, 02-01, Volume: 318, Issue:2

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animal Nutritional Physiological Phenomena

2020
Pentoxifylline inhibits lipopolysaccharide-induced inflammatory mediators in human second trimester placenta explants.
    Placenta, 2017, Volume: 58

    Topics: Anti-Inflammatory Agents; Cytokines; Female; Humans; Inflammation; Inflammation Mediators; Lipopolys

2017
Live birth after Laser Assisted Viability Assessment (LAVA) to detect pentoxifylline resistant ejaculated immotile spermatozoa during ICSI in a couple with male Kartagener's syndrome.
    Reproductive biology and endocrinology : RB&E, 2018, Feb-05, Volume: 16, Issue:1

    Topics: Cell Survival; Female; Humans; Infertility, Male; Kartagener Syndrome; Lasers; Live Birth; Male; Pen

2018
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Adolescent; Adult; Aging; Anti-Inflammatory Agents; Azithromycin; Caspase 1; Cytokines; Dexamethason

2018
Supplementation of biotin to sperm preparation medium enhances fertilizing ability of spermatozoa and improves preimplantation embryo development.
    Journal of assisted reproduction and genetics, 2019, Volume: 36, Issue:2

    Topics: Animals; Asthenozoospermia; Biotin; Blastocyst; Cryopreservation; Culture Media; Embryonic Developme

2019
Post-thaw Addition of Caffeine and/or Pentoxifylline Affect Differently Motility of Horse and Donkey-Cryopreserved Spermatozoa.
    Journal of equine veterinary science, 2019, Volume: 75

    Topics: Animals; Caffeine; Equidae; Female; Horses; Humans; Male; Pentoxifylline; Pregnancy; Sperm Motility;

2019
Protective effects of pentoxifylline on lipopolysaccharide-induced white matter injury in a rat model of periventricular leukomalasia.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:18

    Topics: Animals; Animals, Newborn; Cytoprotection; Disease Models, Animal; Drug Evaluation, Preclinical; Fem

2013
Pentoxifylline attenuates HPV-16 associated necrosis in placental trophoblasts.
    Archives of gynecology and obstetrics, 2015, Volume: 291, Issue:3

    Topics: Animals; Apoptosis; Blastocyst; Cell Survival; Embryo Implantation; Female; Human papillomavirus 16;

2015
Uncommon but devastating event: total fertilisation failure following intracytoplasmic sperm injection.
    Andrologia, 2016, Volume: 48, Issue:2

    Topics: Adult; Cohort Studies; Embryo Transfer; Female; Fertilization in Vitro; Free Radical Scavengers; Hum

2016
Treatment of Peripartum Cardiomyopathy: A Call to Action.
    The Canadian journal of cardiology, 2015, Volume: 31, Issue:12

    Topics: Bromocriptine; Cardiomyopathies; Female; Humans; Hydrazones; Pentoxifylline; Pregnancy; Pregnancy Co

2015
Hypothesis: Pentoxifylline explores new horizons in treatment of preeclampsia.
    Medical hypotheses, 2015, Volume: 85, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Blood Coagulation; Cytokines; Disease Progression; Endothelium, Va

2015
Reactive angioendotheliomatosis as a presenting cutaneous manifestation of Hughes syndrome.
    Lupus, 2015, Volume: 24, Issue:14

    Topics: Abortion, Habitual; Adult; Antibodies, Anticardiolipin; Antibodies, Antiphospholipid; Antiphospholip

2015
Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa.
    Reproductive biomedicine online, 2017, Volume: 34, Issue:4

    Topics: Adult; Female; Humans; Infertility, Male; Male; Pentoxifylline; Pregnancy; Pregnancy Outcome; Retros

2017
Treatment efficacy of trimethoprim sulfamethoxazole, pentoxifylline and altrenogest in experimentally induced equine placentitis.
    Theriogenology, 2010, Volume: 74, Issue:3

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Drug Therapy, Combination; Female; Fetus;

2010
Selection of viable spermatozoa from testicular biopsies: a comparative study between pentoxifylline and hypoosmotic swelling test.
    Fertility and sterility, 2011, Volume: 95, Issue:2

    Topics: Antioxidants; Biopsy; Cell Separation; Cell Survival; Efficiency; Female; Humans; Male; Oocyte Retri

2011
Fresh testicular immotile sperm and viability testing.
    Fertility and sterility, 2011, Volume: 95, Issue:7

    Topics: Biopsy; Cell Survival; Female; Humans; Male; Osmotic Pressure; Pentoxifylline; Pregnancy; Pregnancy

2011
Birth of a healthy infant after intracytoplasmic sperm injection using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.
    Fertility and sterility, 2011, Volume: 95, Issue:7

    Topics: Adult; Ejaculation; Embryo Transfer; Female; Humans; Infertility, Male; Kartagener Syndrome; Live Bi

2011
Uterine artery blood flow remains unchanged in pregnant mares in response to short-term administration of pentoxifylline.
    Theriogenology, 2012, Jan-15, Volume: 77, Issue:2

    Topics: Animals; Female; Gestational Age; Horses; Pentoxifylline; Pregnancy; Pulsatile Flow; Regional Blood

2012
Pentoxifylline and prevention of hyperoxia-induced lung -injury in neonatal rats.
    Pediatric research, 2012, Volume: 71, Issue:5

    Topics: Animals; Animals, Newborn; Enzymes; Female; Hyperoxia; Lung Injury; Macrophages; Pentoxifylline; Pho

2012
Interest of pentoxifylline in ICSI with frozen-thawed testicular spermatozoa from patients with non-obstructive azoospermia.
    Reproductive biomedicine online, 2006, Volume: 12, Issue:1

    Topics: Adult; Cryopreservation; Female; Fertilization; Humans; Male; Oligospermia; Ovulation Induction; Pen

2006
Influence of maternal nicotine exposure on neonatal rat bone: protective effect of pentoxifylline.
    Experimental biology and medicine (Maywood, N.J.), 2007, Volume: 232, Issue:3

    Topics: Animals; Animals, Newborn; Animals, Suckling; Apoptosis; Birth Weight; Body Weight; Bone and Bones;

2007
[Protein-synthesizing apparatus of the rat liver and placenta during damage of the biomembrane by tetrachloromethane and the administration of methylxanthines].
    Voprosy meditsinskoi khimii, 1984, Volume: 30, Issue:6

    Topics: Aminophylline; Animals; Carbon Tetrachloride; Cyclic AMP; Female; Leucine; Liver; Male; Microsomes,

1984
[Changes in hemodynamic parameters and temperature regimen in the system mother-placenta-fetus as affected by various drugs].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 115, Issue:1

    Topics: Animals; Body Temperature Regulation; Dextrans; Female; Hemodynamics; Maternal-Fetal Exchange; Pento

1993
IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau.
    Journal of immunology (Baltimore, Md. : 1950), 1995, May-01, Volume: 154, Issue:9

    Topics: Abortion, Spontaneous; Animals; Decidua; Female; Fetal Resorption; Interferon Type I; Interferon-gam

1995
The influence of pentoxifylline (Trental) on the antifertility effect of intrauterine devices in rats.
    Fertility and sterility, 1994, Volume: 62, Issue:1

    Topics: Animals; Female; Fertility; Intrauterine Devices; Male; Pentoxifylline; Pregnancy; Rats; Rats, Sprag

1994
Effect of pentoxifylline on implantation and post-implantation development of mouse embryos in vitro.
    Human reproduction (Oxford, England), 1993, Volume: 8, Issue:11

    Topics: Animals; Blastocyst; Chorionic Gonadotropin; Culture Techniques; Embryo Implantation; Embryonic and

1993
Motility, acrosome integrity and fertility of frozen ram spermatozoa treated with caffeine, pentoxifylline, cAMP, 2-deoxyadenosine and kallikrein.
    Reproduction, fertility, and development, 1995, Volume: 7, Issue:5

    Topics: Acrosome; Animals; Caffeine; Cryopreservation; Cyclic AMP; Deoxyadenosines; Female; Fertilization; K

1995
Could in vitro fertilization with a modified sperm preparation technique be an option to micromanipulations?
    Journal of assisted reproduction and genetics, 1996, Volume: 13, Issue:9

    Topics: Adult; Deoxyadenosines; Embryo Transfer; Female; Fertilization in Vitro; Humans; Infertility, Male;

1996
Effect of human recombinant tumour necrosis factor-alpha and pentoxifylline on the ultrastructure of type II alveolar epithelial cells in pregnant and non-pregnant rabbits.
    Journal of comparative pathology, 1997, Volume: 117, Issue:3

    Topics: Animals; Disease Models, Animal; Epithelial Cells; Female; Humans; Microscopy, Electron; Pentoxifyll

1997
Micromolar concentration of pentoxifylline improves development in vitro of hamster 8-cell embryos: confirmation of biological viability by embryo transfer.
    Reproduction, fertility, and development, 1997, Volume: 9, Issue:7

    Topics: Animals; Blastocyst; Cricetinae; Culture Media; Culture Techniques; Embryo Transfer; Embryonic and F

1997
[Impaired maternal and fetal hemodynamics in the pathogenesis of gestosis].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2001, Issue:8

    Topics: Adolescent; Adult; Aspirin; Diagnosis, Differential; Female; Hemodynamics; Humans; Models, Theoretic

2001
Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes.
    European journal of obstetrics, gynecology, and reproductive biology, 2001, Volume: 99, Issue:1

    Topics: Albumins; Allopurinol; Animals; Bilirubin; Blood Pressure; Fasting; Female; Heme; Hypertension; Hypo

2001
[Adaptive thermoregulatory reactions of the rabbit fetus at the end of the intrauterine development].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2002, Volume: 88, Issue:1

    Topics: Adaptation, Physiological; Adipose Tissue, Brown; Animals; Body Temperature; Body Temperature Regula

2002
[Effect of trental and rheopolyglucine infusions on the temperature of female rabbits and their fetuses (normally growing and with growth retardation)].
    Akusherstvo i ginekologiia, 1991, Issue:3

    Topics: Animals; Body Temperature Regulation; Dextrans; Drug Combinations; Embryonic and Fetal Development;

1991
[Disorders of the hemostasis system in late pregnancy toxemia and their correction].
    Akusherstvo i ginekologiia, 1990, Issue:11

    Topics: Adult; Anticoagulants; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; He

1990
Lipopolysaccharide-induced fetal resorption in mice is associated with the intrauterine production of tumour necrosis factor-alpha.
    Journal of reproduction and fertility, 1990, Volume: 90, Issue:2

    Topics: Amniotic Fluid; Animals; Female; Fetal Resorption; Gestational Age; Immunohistochemistry; Killer Cel

1990
A pregnancy achieved using sperm from the epididymal caput in idiopathic obstructive azoospermia.
    Fertility and sterility, 1990, Volume: 53, Issue:6

    Topics: Adult; Epididymis; Female; Fertilization in Vitro; Humans; Infertility, Male; Male; Oligospermia; Pe

1990
[Effect of acute "altitude" hypoxia on the transport function of the placenta of the rat with placental insufficiency and its correction using trental].
    Akusherstvo i ginekologiia, 1985, Issue:12

    Topics: Altitude; Animals; Female; Maternal-Fetal Exchange; Pentoxifylline; Placenta; Placenta Diseases; Pla

1985
[Effect of trental on placental transport function and fetal development in hypotrophy].
    Akusherstvo i ginekologiia, 1985, Issue:4

    Topics: Animals; Biological Transport; Embryonic and Fetal Development; Female; Fetal Growth Retardation; Pe

1985
[Effect of injections of parturients with trental on the transfer of exogenous glucose to the fetus].
    Akusherstvo i ginekologiia, 1987, Issue:2

    Topics: Female; Glucose; Humans; Maternal-Fetal Exchange; Obstetric Labor Complications; Pentoxifylline; Pre

1987