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pentoxifylline and Peripheral Vascular Diseases

pentoxifylline has been researched along with Peripheral Vascular Diseases in 42 studies

Peripheral Vascular Diseases: Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.

Research Excerpts

ExcerptRelevanceReference
"To determine the effect of cilostazol on initial and absolute claudication distances, mortality and vascular events in patients with stable intermittent claudication."9.12Cilostazol for intermittent claudication. ( Brown, T; Cleanthis, M; Forster, RB; Mikhailidis, DP; Stansby, G; Stewart, M, 2021)
"To determine the effect of cilostazol (an antiplatelet treatment) on improving initial and absolute claudication distances, and in reducing mortality and vascular events in patients with stable intermittent claudication."8.90Cilostazol for intermittent claudication. ( Bedenis, R; Cleanthis, M; Mikhailidis, DP; Robless, P; Stansby, G; Stewart, M, 2014)
"A systematic review and network meta-analysis was undertaken to consider the evidence for the efficacy and tolerability of placebo, cilostazol, naftidrofuryl oxalate and pentoxifylline in patients with intermittent claudication due to peripheral arterial disease (PAD)."8.88Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication. ( Harnan, S; Meng, Y; Michaels, J; Simpson, E; Squires, H; Stansby, G; Stevens, JW; Thomas, S, 2012)
"To determine the effect of cilostazol on initial and absolute claudication distances, mortality and vascular events in patients with stable intermittent claudication."5.12Cilostazol for intermittent claudication. ( Brown, T; Cleanthis, M; Forster, RB; Mikhailidis, DP; Stansby, G; Stewart, M, 2021)
"To determine the effect of cilostazol (an antiplatelet treatment) on improving initial and absolute claudication distances, and in reducing mortality and vascular events in patients with stable intermittent claudication."4.90Cilostazol for intermittent claudication. ( Bedenis, R; Cleanthis, M; Mikhailidis, DP; Robless, P; Stansby, G; Stewart, M, 2014)
"A systematic review and network meta-analysis was undertaken to consider the evidence for the efficacy and tolerability of placebo, cilostazol, naftidrofuryl oxalate and pentoxifylline in patients with intermittent claudication due to peripheral arterial disease (PAD)."4.88Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication. ( Harnan, S; Meng, Y; Michaels, J; Simpson, E; Squires, H; Stansby, G; Stevens, JW; Thomas, S, 2012)
" For this study, 20 PAD patients were assigned to take either pentoxifylline (n=11) or cilostazol (n=9), the two FDA-approved pharmacological therapies used to treat intermittent claudication symptoms."3.76Treatment with pharmacological agents in peripheral arterial disease patients does not result in biomechanical gait changes. ( Huisinga, JM; Johanning, JM; Pipinos, II; Stergiou, N, 2010)
" Compliance with treatment and occurrence of adverse events were constantly monitored; systemic tolerability was evaluated through the use of routine haematological and haematochemical tests."2.68Controlled clinical trial on the efficacy and safety of oral sulodexide in patients with peripheral occlusive arterial disease. ( Shustov, SB, 1997)
"Food and Drug Administration for the treatment of intermittent claudication, several supplements and investigational agents have been evaluated."2.45Pharmacologic therapy for intermittent claudication. ( Dobesh, PP; Persson, EL; Stacy, ZA, 2009)
"Pyoderma gangrenosum is most commonly treated with immunosuppressants or anti-inflammatory agents and is often worsened by surgical procedures due to the presence of pathergy."1.48Improvement of Ulcerations in Treatment-Resistant Chronic Scarring in a Patient with Pyoderma Gangrenosum After Improving Vascular Insufficiency, Gently Removing Necrotic Debris, and Decreasing Wound Fluid. ( Gordon, C; Hizon, BJ; Mota, JA; Nahm, WJ; Rojas, S, 2018)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's18 (42.86)18.2507
2000's12 (28.57)29.6817
2010's11 (26.19)24.3611
2020's1 (2.38)2.80

Authors

AuthorsStudies
Brown, T1
Forster, RB1
Cleanthis, M2
Mikhailidis, DP2
Stansby, G4
Stewart, M2
Vietto, V1
Franco, JV1
Saenz, V1
Cytryn, D1
Chas, J1
Ciapponi, A1
Nahm, WJ1
Mota, JA1
Rojas, S1
Hizon, BJ1
Gordon, C1
Słoczyńska, K1
Kózka, M1
Pękala, E1
Marchewka, A1
Marona, H1
Roset, PN1
Stevens, JW2
Simpson, E2
Harnan, S2
Squires, H2
Meng, Y2
Thomas, S2
Michaels, J2
Bedenis, R1
Robless, P1
Dobesh, PP1
Stacy, ZA1
Persson, EL1
Huisinga, JM2
Pipinos, II2
Johanning, JM2
Stergiou, N2
Olin, JW1
Sealove, BA1
Sheck, L1
Bachoo, P2
Koshkin, VM1
Tulsyan, N1
Ouriel, K1
Kashyap, VS1
Kim, DH1
Regensteiner, JG3
Stewart, KJ1
Creager, MA1
Pande, RL1
Hiatt, WR3
Lipsitz, EC1
Kim, S1
Scheffler, P1
de la Hamette, D1
Gross, J1
Mueller, H1
Schieffer, H1
Campbell, RK1
Opler, LA1
Gorman, JM1
Isner, JM1
Rosenfield, K1
Frampton, JE1
Brogden, RN1
Vadiei, K1
Tucker, SD1
Lopez-Berestein, G1
Wasan, KM1
Ciocon, JO1
Galindo-Ciocon, D1
Galindo, DJ1
Kohout, J1
Hůzl, F1
Bejcková, H1
Soukupová, K1
Labs, KH1
Labs, R1
Rössner, M1
Shustov, SB1
Langley, PC1
Coons, SJ1
Dosquet, C1
Weill, D1
Wautier, JL1
Cummings, DM1
Ballas, SK1
Ellison, MJ1
Ernst, E1
Kollár, L1
Resch, KL1
Elliot, EC1
Kollarits, CR1
Ciuffetti, G1
Mercuri, M1
Ott, C1
Lombardini, R1
Paltriccia, R1
Lupattelli, G1
Santambrogio, L1
Mannarino, E1
Poflee, VW1
Gupta, OP1
Jain, AP1
Jajoo, UN1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)[NCT03883412]Phase 460 participants (Anticipated)Interventional2019-02-28Recruiting
The THOR IDE Study[NCT05916950]155 participants (Anticipated)Interventional2023-08-31Not yet recruiting
Multicenter, Randomized, Dose-search, Parallel, Double-blind, and Placebo-controlled Clinical Trial to Evaluate the Safety and Efficacy of Intramuscular Administration of Allogeneic Adipose Tissue Adult Mesenchymal Stem Cells in Diabetic Patients With Cri[NCT04466007]Phase 290 participants (Anticipated)Interventional2021-01-11Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

19 reviews available for pentoxifylline and Peripheral Vascular Diseases

ArticleYear
Cilostazol for intermittent claudication.
    The Cochrane database of systematic reviews, 2021, 06-30, Volume: 6

    Topics: Aged; Bias; Cilostazol; Humans; Intermittent Claudication; Middle Aged; Myocardial Infarction; Pento

2021
Prostanoids for critical limb ischaemia.
    The Cochrane database of systematic reviews, 2018, 01-10, Volume: 1

    Topics: Alprostadil; Amputation, Surgical; Epoprostenol; Humans; Iloprost; Ischemia; Leg; Leg Ulcer; Nafrony

2018
Cilostazol for intermittent claudication.
    The Cochrane database of systematic reviews, 2014, Oct-31, Issue:10

    Topics: Aged; Cilostazol; Humans; Intermittent Claudication; Middle Aged; Myocardial Infarction; Pentoxifyll

2014
Pharmacologic therapy for intermittent claudication.
    Pharmacotherapy, 2009, Volume: 29, Issue:5

    Topics: Cilostazol; Clinical Trials as Topic; Dietary Supplements; Drugs, Investigational; Exercise Therapy;

2009
Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication.
    The British journal of surgery, 2012, Volume: 99, Issue:12

    Topics: Cilostazol; Humans; Intermittent Claudication; Nafronyl; Pain; Pentoxifylline; Peripheral Vascular D

2012
Peripheral arterial disease.
    Clinical evidence, 2003, Issue:9

    Topics: Angioplasty, Balloon; Cilostazol; Exercise; Humans; Intermittent Claudication; Pentoxifylline; Perip

2003
Peripheral arterial disease.
    Clinical evidence, 2004, Issue:11

    Topics: Angioplasty, Balloon; Cilostazol; Exercise; Humans; Pentoxifylline; Peripheral Vascular Diseases; Pl

2004
Peripheral arterial disease.
    Clinical evidence, 2004, Issue:12

    Topics: Angioplasty, Balloon; Cilostazol; Coronary Artery Bypass; Exercise; Humans; Pentoxifylline; Peripher

2004
[The use of pentoxyphylline in the treatment of patients with chronic obliterative diseases of lower limb arteries].
    Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery, 2005, Volume: 11, Issue:4

    Topics: Administration, Oral; Arterial Occlusive Diseases; Blood Cells; Chronic Disease; Controlled Clinical

2005
Emerging drugs in peripheral arterial disease.
    Expert opinion on emerging drugs, 2006, Volume: 11, Issue:1

    Topics: Administration, Oral; Anticoagulants; Arterial Occlusive Diseases; Arteries; Aspirin; Clopidogrel; D

2006
Established and evolving medical therapies for claudication in patients with peripheral arterial disease.
    Nature clinical practice. Cardiovascular medicine, 2006, Volume: 3, Issue:11

    Topics: Ankle; Arterial Occlusive Diseases; Blood Pressure; Brachial Artery; Cilostazol; Exercise Test; Exer

2006
Clinical update on pentoxifylline therapy for diabetes-induced peripheral vascular disease.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:9

    Topics: Clinical Trials as Topic; Diabetes Complications; Diabetic Angiopathies; Diabetic Foot; Female; Huma

1993
Redefining the treatment of peripheral artery disease. Role of percutaneous revascularization.
    Circulation, 1993, Volume: 88, Issue:4 Pt 1

    Topics: Angioplasty, Balloon; Angioplasty, Balloon, Laser-Assisted; Angioplasty, Laser; Arterial Occlusive D

1993
Redefining the treatment of peripheral artery disease. Role of percutaneous revascularization.
    Circulation, 1993, Volume: 88, Issue:4 Pt 1

    Topics: Angioplasty, Balloon; Angioplasty, Balloon, Laser-Assisted; Angioplasty, Laser; Arterial Occlusive D

1993
Redefining the treatment of peripheral artery disease. Role of percutaneous revascularization.
    Circulation, 1993, Volume: 88, Issue:4 Pt 1

    Topics: Angioplasty, Balloon; Angioplasty, Balloon, Laser-Assisted; Angioplasty, Laser; Arterial Occlusive D

1993
Redefining the treatment of peripheral artery disease. Role of percutaneous revascularization.
    Circulation, 1993, Volume: 88, Issue:4 Pt 1

    Topics: Angioplasty, Balloon; Angioplasty, Balloon, Laser-Assisted; Angioplasty, Laser; Arterial Occlusive D

1993
Nonsurgical management of peripheral arterial disease.
    Hospital practice (Office ed.), 1993, Feb-15, Volume: 28, Issue:2

    Topics: Activities of Daily Living; Aged; Angioplasty; Arterial Occlusive Diseases; Clinical Protocols; Exer

1993
Pentoxifylline (oxpentifylline). A review of its therapeutic efficacy in the management of peripheral vascular and cerebrovascular disorders.
    Drugs & aging, 1995, Volume: 7, Issue:6

    Topics: Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Pentoxifylline; Peripheral Vascul

1995
Clinical experience with pentoxifylline.
    Atherosclerosis, 1997, Volume: 131 Suppl

    Topics: Humans; Intermittent Claudication; Pentoxifylline; Peripheral Vascular Diseases; Vasodilator Agents

1997
Peripheral vascular disorders. A pharmacoeconomic and quality-of-life review.
    PharmacoEconomics, 1997, Volume: 11, Issue:3

    Topics: Cost-Benefit Analysis; Humans; Pentoxifylline; Peripheral Vascular Diseases; Quality of Life

1997
Current medical therapies for patients with peripheral arterial disease: a critical review.
    The American journal of medicine, 2002, Volume: 112, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Arteriosclerosis; Cardiovascular Diseases; Cilostazol; Dia

2002
Molecular mechanism of blood monocyte adhesion to vascular endothelial cells.
    Nouvelle revue francaise d'hematologie, 1992, Volume: 34 Suppl

    Topics: Cell Adhesion; Cell Adhesion Molecules; Diabetes Mellitus, Type 1; Endothelium, Vascular; Humans; In

1992

Trials

8 trials available for pentoxifylline and Peripheral Vascular Diseases

ArticleYear
A randomized trial of iloprost in patients with intermittent claudication.
    Vascular medicine (London, England), 2008, Volume: 13, Issue:1

    Topics: Administration, Oral; Aged; Double-Blind Method; Female; Humans; Iloprost; Intermittent Claudication

2008
Intensive vascular training in stage IIb of peripheral arterial occlusive disease. The additive effects of intravenous prostaglandin E1 or intravenous pentoxifylline during training.
    Circulation, 1994, Volume: 90, Issue:2

    Topics: Alprostadil; Arterial Occlusive Diseases; Combined Modality Therapy; Exercise Therapy; Female; Follo

1994
A comparison between aspirin and pentoxifylline in relieving claudication due to peripheral vascular disease in the elderly.
    Angiology, 1997, Volume: 48, Issue:3

    Topics: Aged; Aspirin; Female; Humans; Intermittent Claudication; Male; Pentoxifylline; Peripheral Vascular

1997
Treatment of vascular disease caused by vibration.
    Central European journal of public health, 1995, Volume: 3 Suppl

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Cumulative Trauma Disorders; Gases; Humans; Injections, S

1995
Controlled clinical trial on the efficacy and safety of oral sulodexide in patients with peripheral occlusive arterial disease.
    Current medical research and opinion, 1997, Volume: 13, Issue:10

    Topics: Administration, Oral; Aged; Arterial Occlusive Diseases; Drug Monitoring; Female; Glycosaminoglycans

1997
Does pentoxifylline prolong the walking distance in exercised claudicants? A placebo-controlled double-blind trial.
    Angiology, 1992, Volume: 43, Issue:2

    Topics: Administration, Oral; Combined Modality Therapy; Double-Blind Method; Exercise Therapy; Humans; Inte

1992
Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease. Results of a double-blind placebo-controlled study.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:6

    Topics: Cross-Sectional Studies; Double-Blind Method; Female; Free Radicals; Humans; Leukocytes; Longitudina

1991
Haemorheological treatment of painful sickle cell crises. Use of pentoxifylline.
    The Journal of the Association of Physicians of India, 1991, Volume: 39, Issue:8

    Topics: Adult; Anemia, Sickle Cell; Humans; Pain; Pentoxifylline; Peripheral Vascular Diseases

1991

Other Studies

15 other studies available for pentoxifylline and Peripheral Vascular Diseases

ArticleYear
Improvement of Ulcerations in Treatment-Resistant Chronic Scarring in a Patient with Pyoderma Gangrenosum After Improving Vascular Insufficiency, Gently Removing Necrotic Debris, and Decreasing Wound Fluid.
    The American journal of case reports, 2018, Jul-19, Volume: 19

    Topics: Adult; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Chronic Disease; Cicatrix; Clobetasol

2018
In vitro effect of pentoxifylline and lisofylline on deformability and aggregation of red blood cells from healthy subjects and patients with chronic venous disease.
    Acta biochimica Polonica, 2013, Volume: 60, Issue:1

    Topics: Adult; Cells, Cultured; Erythrocyte Aggregation; Erythrocyte Deformability; Erythrocytes; Hemorheolo

2013
Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication (Br J Surg 2012; 99: 1630-1638).
    The British journal of surgery, 2013, Volume: 100, Issue:13

    Topics: Humans; Intermittent Claudication; Nafronyl; Pentoxifylline; Peripheral Vascular Diseases; Tetrazole

2013
Authors' reply: systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication (Br J Surg 2012; 99: 1630-1638).
    The British journal of surgery, 2013, Volume: 100, Issue:13

    Topics: Humans; Intermittent Claudication; Nafronyl; Pentoxifylline; Peripheral Vascular Diseases; Tetrazole

2013
The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients.
    Journal of neuroengineering and rehabilitation, 2010, Jun-07, Volume: 7

    Topics: Aged; Biomechanical Phenomena; Cardiovascular Agents; Case-Control Studies; Cilostazol; Dyskinesias;

2010
Peripheral artery disease: current insight into the disease and its diagnosis and management.
    Mayo Clinic proceedings, 2010, Volume: 85, Issue:7

    Topics: Ankle Brachial Index; Cardiovascular Diseases; Cilostazol; Diagnosis, Differential; Disease Progress

2010
Treatment with pharmacological agents in peripheral arterial disease patients does not result in biomechanical gait changes.
    Journal of applied biomechanics, 2010, Volume: 26, Issue:3

    Topics: Aged; Analysis of Variance; Biomechanical Phenomena; Cilostazol; Female; Gait; Humans; Imaging, Thre

2010
Selenium and the course of mild Graves' orbitopathy.
    The New England journal of medicine, 2011, 08-25, Volume: 365, Issue:8

    Topics: Antioxidants; Diabetes Mellitus, Type 2; Glaucoma; Graves Ophthalmopathy; Humans; New Zealand; Pento

2011
Exercise and peripheral arterial disease.
    Annals of internal medicine, 2006, May-02, Volume: 144, Issue:9

    Topics: Cilostazol; Exercise Therapy; Humans; Intermittent Claudication; Pentoxifylline; Peripheral Vascular

2006
Antithrombotic therapy in peripheral arterial disease.
    Cardiology clinics, 2008, Volume: 26, Issue:2

    Topics: Anticoagulants; Aspirin; Atherosclerosis; Cilostazol; Clopidogrel; Comorbidity; Diabetic Angiopathie

2008
Pentoxifylline and panic attacks.
    The American journal of psychiatry, 1994, Volume: 151, Issue:2

    Topics: Aged; Humans; Male; Panic Disorder; Pentoxifylline; Peripheral Vascular Diseases

1994
Nephroprotective mechanism(s) of pentoxifylline: reduction of erythrocyte-mediated vascular congestion and inhibition of nitric oxide release.
    Pharmacology & toxicology, 1996, Volume: 78, Issue:3

    Topics: Animals; Erythrocytes; Ischemia; Kidney; Kidney Diseases; Male; Nitric Oxide; Pentoxifylline; Periph

1996
A new treatment for peripheral arterial disease.
    Harvard heart letter : from Harvard Medical School, 2001, Volume: 11, Issue:8

    Topics: Cilostazol; Humans; Intermittent Claudication; Pentoxifylline; Peripheral Vascular Diseases; Platele

2001
Lack of effect of pentoxifylline on red blood cell deformability.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:11

    Topics: Adult; Erythrocyte Deformability; Female; Humans; Male; Pentoxifylline; Peripheral Vascular Diseases

1992
Expansion of contracted visual fields following treatment with pentoxifylline in two patients with coexistent peripheral vascular disease--case reports.
    Angiology, 1992, Volume: 43, Issue:4

    Topics: Aged; Humans; Intermittent Claudication; Ischemia; Leg; Male; Middle Aged; Pentoxifylline; Periphera

1992