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pentoxifylline and Neoplasm Metastasis

pentoxifylline has been researched along with Neoplasm Metastasis in 18 studies

Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Research Excerpts

ExcerptRelevanceReference
" As per the reports, the choice of drug in the treatment of breast cancer is paclitaxel, but the major limitation is its toxicity."7.77Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells. ( Goel, PN; Gude, RP, 2011)
"Our clinical study to prevent relapse and metastases in several sarcomas and malignant lymphomas of the head and neck region with a long-term treatment with mopidamole was initiated in 1972 because the pyrimido-pyrimidine derivative was shown to inhibit platelet aggregation in vivo and to increase significantly the circulation time of intravenously injected, 32P-labelled Ehrlich ascites tumour cells in mouse blood."4.76[Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results]. ( Gastpar, H, 1983)
" As per the reports, the choice of drug in the treatment of breast cancer is paclitaxel, but the major limitation is its toxicity."3.77Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells. ( Goel, PN; Gude, RP, 2011)
" In the present study, enhancement in the antimetastatic activity of etoposide (ETP) by encapsulation in sterically stabilized liposomes was evaluated in the murine experimental B16F10 melanoma model."3.72Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice. ( Gude, RP; Nagarsenker, MS; Rao, SG; Sant, VP, 2003)
" pentoxifylline (Px) (which also were found to release PgI2 and t-PA) inhibited human tumor implant induced angiogenesis and reduced spontaneous metastases in 3 transplantable murine tumors (Furth-Columbia Wilms' tumor in Furth-Wistar rats, C-1300 neuroblastoma in A/J mice and HM-Kim mammary carcinoma in Wistar rats) but not in the NIH adenocarcinoma in Balb/c mice."3.68Studies on tumor induced angiogenesis. ( Ambrus, CM; Ambrus, JL; Forgach, P; Halpern, J; Niswander, P; Sayyid, S; Stadler, S; Toumbis, C, 1992)
"In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline)."3.67Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. ( Grimová, J; Kacerovská, H; Mamytbeková, A; Rezábek, K; Svobodová, J, 1986)
"Pentoxifylline (Trental), a phosphodiesterase inhibitor with platelet aggregation inhibitory effect, was shown to decrease spontaneous metastases in a Wilms' tumor model in Furth-Wistar rats and in neuroblastoma C1300 in A/J mice."3.66Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis. ( Ambrus, JL; Cohen, H; Gastpar, H; Gordon, S; Murphy, GP; Sciandra, J; Williams, P; Witul, M, 1979)
"Patients with liver metastases from colorectal carcinoma who were scheduled for local ablation by radiotherapy (image-guided high-dose-rate interstitial brachytherapy) were prospectively randomized to receive PTX, UDCA and LMWH for 8 weeks (treatment) or no medication (control)."2.79Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity. ( Damm, R; Gademann, G; Hass, P; Kropf, S; Mohnike, K; Pech, M; Ricke, J; Sangro, B; Seidensticker, M; Seidensticker, R; Wust, P, 2014)
"Although no lung metastasis was observed in the rats killed at the end of the period of carcinogen exposure, lung metastasis was found in 100% of animals in all the groups at the end of the experiment."1.32Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma. ( Futakuchi, M; Ogawa, K; Shirai, T; Takahashi, S; Tamano, S, 2004)
"Pentoxifylline has been shown to exhibit anti-metastatic activity by inhibiting homing of B16F10 melanoma cells in the murine experimental metastasis model."1.31Enhancement of anti-metastatic activity of pentoxifylline by encapsulation in conventional liposomes and sterically stabilized liposomes in murine experimental B16F10 melanoma model. ( Gude, RP; Nagarsenker, MS; Rao, SG; Sant, VP, 2000)
"Distant metastasis (DM) is the most common mode of recurrence among patients with advanced head and neck carcinoma treated with intra-arterial cisplatin and radiotherapy (RADPLAT)."1.31Analysis of risk factors predictive of distant failure after targeted chemoradiation for advanced head and neck cancer. ( Doweck, I; Robbins, KT; Vieira, F, 2001)
" In the present experiment pentoxifylline appears to be a highly effective platelet aggregation inhibitor: a dose-response curve is apparent in monkey between 6 and 24 mg/kg i."1.26Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis. ( Ambrus, CM; Ambrus, JL; Gastpar, H, 1981)
"The mechanism of the early stage of metastasis formation by sticky blood-born cancer cells is discussed."1.26Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis. ( Gastpar, H, 1977)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19908 (44.44)18.7374
1990's2 (11.11)18.2507
2000's5 (27.78)29.6817
2010's3 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goel, PN2
Gude, RP4
Seidensticker, M1
Seidensticker, R1
Damm, R1
Mohnike, K1
Pech, M1
Sangro, B1
Hass, P1
Wust, P1
Kropf, S1
Gademann, G1
Ricke, J1
Andela, VB1
Gingold, BI1
Souza, MD1
O'Keefe, RJ1
Puzas, EJ1
Schwarz, EM1
Rosier, RN1
Sant, VP2
Nagarsenker, MS2
Rao, SG2
Futakuchi, M1
Ogawa, K1
Tamano, S1
Takahashi, S1
Shirai, T1
Ambrus, JL6
Ambrus, CM5
Gastpar, H7
Amirkhosravi, A1
Meyer, T1
Warnes, G1
Amaya, M1
Malik, Z1
Biggerstaff, JP1
Siddiqui, FA1
Sherman, P1
Francis, JL1
Doweck, I1
Robbins, KT1
Vieira, F1
Gordon, S1
Witul, M1
Cohen, H1
Sciandra, J1
Williams, P1
Murphy, GP1
Forgach, P1
Stadler, S1
Halpern, J1
Sayyid, S1
Niswander, P1
Toumbis, C1
Mamytbeková, A1
Rezábek, K1
Kacerovská, H1
Grimová, J1
Svobodová, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity After Brachytherapy of Liver Metastases From Colorectal Carcinoma, Assessed in a Prospective Randomised Trial[NCT01149304]Phase 222 participants (Actual)Interventional2009-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for pentoxifylline and Neoplasm Metastasis

ArticleYear
[Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results].
    Laryngologie, Rhinologie, Otologie, 1983, Volume: 62, Issue:12

    Topics: Animals; Bencyclane; Cell Adhesion; Cells, Cultured; Dipyridamole; Humans; Lymphocytes; Mice; Mopida

1983

Trials

1 trial available for pentoxifylline and Neoplasm Metastasis

ArticleYear
Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Aged; Aged, 80 and over; Brachytherapy; Colorectal Neoplasms; Enoxaparin; Female; Humans; Liver Neop

2014

Other Studies

16 other studies available for pentoxifylline and Neoplasm Metastasis

ArticleYear
Delineating the anti-metastatic potential of pentoxifylline in combination with liposomal doxorubicin against breast cancer cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Adhesion; Cell Culture Tech

2014
Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells.
    Molecular and cellular biochemistry, 2011, Volume: 358, Issue:1-2

    Topics: Acridine Orange; Apoptosis; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Move

2011
Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.
    Cancer letters, 2003, May-08, Volume: 194, Issue:1

    Topics: Animals; Antineoplastic Agents; Collagen; Cyclic AMP; Disease Progression; Drug Combinations; Female

2003
Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice.
    Cancer biotherapy & radiopharmaceuticals, 2003, Volume: 18, Issue:5

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; E

2003
Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma.
    Cancer science, 2004, Volume: 95, Issue:1

    Topics: Acetylcysteine; Animals; Aspirin; Blotting, Western; Carcinogens; Diethylnitrosamine; E-Selectin; En

2004
Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis.
    La Ricerca in clinica e in laboratorio, 1981, Volume: 11 Suppl 1

    Topics: Adenocarcinoma; Adenosine Diphosphate; Animals; Carcinoma, Ehrlich Tumor; Female; Head and Neck Neop

1981
Platelet aggregation inhibitors in the prevention of metastasis in neoplastic disease: a review of experimental and clinical investigations.
    Journal of medicine, 1981, Volume: 12, Issue:1

    Topics: Animals; Bencyclane; Blood Coagulation; Carcinoma 256, Walker; Depression, Chemical; Dipyridamole; D

1981
Platelet cancer cell interaction in metastasis formation. Platelet aggregation inhibitors: a possible approach to metastasis prevention.
    Progress in clinical and biological research, 1982, Volume: 89

    Topics: Animals; Bencyclane; Blood Platelet Disorders; Blood Platelets; Carcinoma 256, Walker; Cell Adhesion

1982
Platelet aggregation inhibitors and metastatic spread of neoplastic cells.
    Progress in clinical and biological research, 1982, Volume: 89

    Topics: Animals; Blood Platelets; Female; Humans; Male; Mice; Mopidamol; Neoplasm Metastasis; Neoplasm Trans

1982
Pentoxifylline inhibits hypoxia-induced upregulation of tumor cell tissue factor and vascular endothelial growth factor.
    Thrombosis and haemostasis, 1998, Volume: 80, Issue:4

    Topics: Animals; Cell Hypoxia; Endothelial Growth Factors; Free Radical Scavengers; Humans; Lymphokines; Neo

1998
Enhancement of anti-metastatic activity of pentoxifylline by encapsulation in conventional liposomes and sterically stabilized liposomes in murine experimental B16F10 melanoma model.
    The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:12

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Female; Liposom

2000
Analysis of risk factors predictive of distant failure after targeted chemoradiation for advanced head and neck cancer.
    Archives of otolaryngology--head & neck surgery, 2001, Volume: 127, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Enzyme Inhibitors; Female;

2001
Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis.
    Journal of medicine, 1979, Volume: 10, Issue:6

    Topics: Adenocarcinoma; Animals; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neoplasm M

1979
Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis.
    Journal of medicine, 1977, Volume: 8, Issue:2

    Topics: Animals; Bencyclane; Blood Coagulation; Carcinoma 256, Walker; Cell Adhesion; Dipyridamole; Dissemin

1977
Studies on tumor induced angiogenesis.
    EXS, 1992, Volume: 61

    Topics: Adenocarcinoma; Aminocaproic Acid; Animals; Cornea; Ditiocarb; Humans; Kidney Neoplasms; Macaca; Mam

1992
Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors.
    Neoplasma, 1986, Volume: 33, Issue:4

    Topics: Animals; Antineoplastic Agents; Dipyridamole; Flurbiprofen; Lung Neoplasms; Male; Mice; Mice, Inbred

1986