pentoxifylline has been researched along with Neoplasm Metastasis in 18 studies
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As per the reports, the choice of drug in the treatment of breast cancer is paclitaxel, but the major limitation is its toxicity." | 7.77 | Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells. ( Goel, PN; Gude, RP, 2011) |
| "Our clinical study to prevent relapse and metastases in several sarcomas and malignant lymphomas of the head and neck region with a long-term treatment with mopidamole was initiated in 1972 because the pyrimido-pyrimidine derivative was shown to inhibit platelet aggregation in vivo and to increase significantly the circulation time of intravenously injected, 32P-labelled Ehrlich ascites tumour cells in mouse blood." | 4.76 | [Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results]. ( Gastpar, H, 1983) |
| " As per the reports, the choice of drug in the treatment of breast cancer is paclitaxel, but the major limitation is its toxicity." | 3.77 | Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells. ( Goel, PN; Gude, RP, 2011) |
| " In the present study, enhancement in the antimetastatic activity of etoposide (ETP) by encapsulation in sterically stabilized liposomes was evaluated in the murine experimental B16F10 melanoma model." | 3.72 | Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice. ( Gude, RP; Nagarsenker, MS; Rao, SG; Sant, VP, 2003) |
| " pentoxifylline (Px) (which also were found to release PgI2 and t-PA) inhibited human tumor implant induced angiogenesis and reduced spontaneous metastases in 3 transplantable murine tumors (Furth-Columbia Wilms' tumor in Furth-Wistar rats, C-1300 neuroblastoma in A/J mice and HM-Kim mammary carcinoma in Wistar rats) but not in the NIH adenocarcinoma in Balb/c mice." | 3.68 | Studies on tumor induced angiogenesis. ( Ambrus, CM; Ambrus, JL; Forgach, P; Halpern, J; Niswander, P; Sayyid, S; Stadler, S; Toumbis, C, 1992) |
| "In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline)." | 3.67 | Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. ( Grimová, J; Kacerovská, H; Mamytbeková, A; Rezábek, K; Svobodová, J, 1986) |
| "Pentoxifylline (Trental), a phosphodiesterase inhibitor with platelet aggregation inhibitory effect, was shown to decrease spontaneous metastases in a Wilms' tumor model in Furth-Wistar rats and in neuroblastoma C1300 in A/J mice." | 3.66 | Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis. ( Ambrus, JL; Cohen, H; Gastpar, H; Gordon, S; Murphy, GP; Sciandra, J; Williams, P; Witul, M, 1979) |
| "Patients with liver metastases from colorectal carcinoma who were scheduled for local ablation by radiotherapy (image-guided high-dose-rate interstitial brachytherapy) were prospectively randomized to receive PTX, UDCA and LMWH for 8 weeks (treatment) or no medication (control)." | 2.79 | Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity. ( Damm, R; Gademann, G; Hass, P; Kropf, S; Mohnike, K; Pech, M; Ricke, J; Sangro, B; Seidensticker, M; Seidensticker, R; Wust, P, 2014) |
| "Although no lung metastasis was observed in the rats killed at the end of the period of carcinogen exposure, lung metastasis was found in 100% of animals in all the groups at the end of the experiment." | 1.32 | Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma. ( Futakuchi, M; Ogawa, K; Shirai, T; Takahashi, S; Tamano, S, 2004) |
| "Pentoxifylline has been shown to exhibit anti-metastatic activity by inhibiting homing of B16F10 melanoma cells in the murine experimental metastasis model." | 1.31 | Enhancement of anti-metastatic activity of pentoxifylline by encapsulation in conventional liposomes and sterically stabilized liposomes in murine experimental B16F10 melanoma model. ( Gude, RP; Nagarsenker, MS; Rao, SG; Sant, VP, 2000) |
| "Distant metastasis (DM) is the most common mode of recurrence among patients with advanced head and neck carcinoma treated with intra-arterial cisplatin and radiotherapy (RADPLAT)." | 1.31 | Analysis of risk factors predictive of distant failure after targeted chemoradiation for advanced head and neck cancer. ( Doweck, I; Robbins, KT; Vieira, F, 2001) |
| " In the present experiment pentoxifylline appears to be a highly effective platelet aggregation inhibitor: a dose-response curve is apparent in monkey between 6 and 24 mg/kg i." | 1.26 | Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis. ( Ambrus, CM; Ambrus, JL; Gastpar, H, 1981) |
| "The mechanism of the early stage of metastasis formation by sticky blood-born cancer cells is discussed." | 1.26 | Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis. ( Gastpar, H, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (44.44) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goel, PN | 2 |
| Gude, RP | 4 |
| Seidensticker, M | 1 |
| Seidensticker, R | 1 |
| Damm, R | 1 |
| Mohnike, K | 1 |
| Pech, M | 1 |
| Sangro, B | 1 |
| Hass, P | 1 |
| Wust, P | 1 |
| Kropf, S | 1 |
| Gademann, G | 1 |
| Ricke, J | 1 |
| Andela, VB | 1 |
| Gingold, BI | 1 |
| Souza, MD | 1 |
| O'Keefe, RJ | 1 |
| Puzas, EJ | 1 |
| Schwarz, EM | 1 |
| Rosier, RN | 1 |
| Sant, VP | 2 |
| Nagarsenker, MS | 2 |
| Rao, SG | 2 |
| Futakuchi, M | 1 |
| Ogawa, K | 1 |
| Tamano, S | 1 |
| Takahashi, S | 1 |
| Shirai, T | 1 |
| Ambrus, JL | 6 |
| Ambrus, CM | 5 |
| Gastpar, H | 7 |
| Amirkhosravi, A | 1 |
| Meyer, T | 1 |
| Warnes, G | 1 |
| Amaya, M | 1 |
| Malik, Z | 1 |
| Biggerstaff, JP | 1 |
| Siddiqui, FA | 1 |
| Sherman, P | 1 |
| Francis, JL | 1 |
| Doweck, I | 1 |
| Robbins, KT | 1 |
| Vieira, F | 1 |
| Gordon, S | 1 |
| Witul, M | 1 |
| Cohen, H | 1 |
| Sciandra, J | 1 |
| Williams, P | 1 |
| Murphy, GP | 1 |
| Forgach, P | 1 |
| Stadler, S | 1 |
| Halpern, J | 1 |
| Sayyid, S | 1 |
| Niswander, P | 1 |
| Toumbis, C | 1 |
| Mamytbeková, A | 1 |
| Rezábek, K | 1 |
| Kacerovská, H | 1 |
| Grimová, J | 1 |
| Svobodová, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity After Brachytherapy of Liver Metastases From Colorectal Carcinoma, Assessed in a Prospective Randomised Trial[NCT01149304] | Phase 2 | 22 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pentoxifylline and Neoplasm Metastasis
| Article | Year |
|---|---|
[Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results].
Topics: Animals; Bencyclane; Cell Adhesion; Cells, Cultured; Dipyridamole; Humans; Lymphocytes; Mice; Mopida | 1983 |
1 trial available for pentoxifylline and Neoplasm Metastasis
| Article | Year |
|---|---|
Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity.
Topics: Aged; Aged, 80 and over; Brachytherapy; Colorectal Neoplasms; Enoxaparin; Female; Humans; Liver Neop | 2014 |
16 other studies available for pentoxifylline and Neoplasm Metastasis
| Article | Year |
|---|---|
Delineating the anti-metastatic potential of pentoxifylline in combination with liposomal doxorubicin against breast cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Adhesion; Cell Culture Tech | 2014 |
Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells.
Topics: Acridine Orange; Apoptosis; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Move | 2011 |
Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.
Topics: Animals; Antineoplastic Agents; Collagen; Cyclic AMP; Disease Progression; Drug Combinations; Female | 2003 |
Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; E | 2003 |
Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma.
Topics: Acetylcysteine; Animals; Aspirin; Blotting, Western; Carcinogens; Diethylnitrosamine; E-Selectin; En | 2004 |
Effect of phosphodiesterase inhibitors on platelet aggregation and tumor metastasis.
Topics: Adenocarcinoma; Adenosine Diphosphate; Animals; Carcinoma, Ehrlich Tumor; Female; Head and Neck Neop | 1981 |
Platelet aggregation inhibitors in the prevention of metastasis in neoplastic disease: a review of experimental and clinical investigations.
Topics: Animals; Bencyclane; Blood Coagulation; Carcinoma 256, Walker; Depression, Chemical; Dipyridamole; D | 1981 |
Platelet cancer cell interaction in metastasis formation. Platelet aggregation inhibitors: a possible approach to metastasis prevention.
Topics: Animals; Bencyclane; Blood Platelet Disorders; Blood Platelets; Carcinoma 256, Walker; Cell Adhesion | 1982 |
Platelet aggregation inhibitors and metastatic spread of neoplastic cells.
Topics: Animals; Blood Platelets; Female; Humans; Male; Mice; Mopidamol; Neoplasm Metastasis; Neoplasm Trans | 1982 |
Pentoxifylline inhibits hypoxia-induced upregulation of tumor cell tissue factor and vascular endothelial growth factor.
Topics: Animals; Cell Hypoxia; Endothelial Growth Factors; Free Radical Scavengers; Humans; Lymphokines; Neo | 1998 |
Enhancement of anti-metastatic activity of pentoxifylline by encapsulation in conventional liposomes and sterically stabilized liposomes in murine experimental B16F10 melanoma model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Female; Liposom | 2000 |
Analysis of risk factors predictive of distant failure after targeted chemoradiation for advanced head and neck cancer.
Topics: Adult; Aged; Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Enzyme Inhibitors; Female; | 2001 |
Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis.
Topics: Adenocarcinoma; Animals; Lung Neoplasms; Male; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neoplasm M | 1979 |
Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis.
Topics: Animals; Bencyclane; Blood Coagulation; Carcinoma 256, Walker; Cell Adhesion; Dipyridamole; Dissemin | 1977 |
Studies on tumor induced angiogenesis.
Topics: Adenocarcinoma; Aminocaproic Acid; Animals; Cornea; Ditiocarb; Humans; Kidney Neoplasms; Macaca; Mam | 1992 |
Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors.
Topics: Animals; Antineoplastic Agents; Dipyridamole; Flurbiprofen; Lung Neoplasms; Male; Mice; Mice, Inbred | 1986 |