pentoxifylline has been researched along with Melanoma in 16 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor is known to inhibit the growth of various cancer cells including melanoma." | 7.83 | Pentoxifylline triggers autophagy via ER stress response that interferes with Pentoxifylline induced apoptosis in human melanoma cells. ( Dutta, RK; Ishaq, M; Khan, MA; Majumdar, S; Sharma, G; Sharma, K, 2016) |
| "Our results indicate that pentoxifylline inhibits the activity of the canonical WNT pathway in melanoma cell populations with high basal activity of this signalling." | 7.83 | Pentoxifylline Inhibits WNT Signalling in β-Cateninhigh Patient-Derived Melanoma Cell Populations. ( Chouaib, S; Czyz, M; Gajos-Michniewicz, A; Talar, B; Talar, M, 2016) |
| " Pentoxifylline (PTX), a methyl xanthine derivative, inhibits B16F10 melanoma lung homing by inhibiting F10 invasion, MMP secretion and adhesion to matrix components." | 7.74 | Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation. ( Dua, P; Gude, RP, 2008) |
| "The influence of pentoxifylline on radiotoxicity was assessed by colony assay in TP53 wild-type Bell and mutant MeWo melanoma, and in TP53 wild-type 4197 and mutant 4451 squamous cell carcinoma (SCC) cell lines." | 7.70 | The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline. ( Binder, A; Böhm, L; Theron, T; Verheye-Dua, F, 2000) |
| "Melanoma is the most common malignant skin cancer, appears indestructible and is notoriously resistant to all current modalities of cancer treatment strategies." | 5.38 | Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line. ( Gude, RP; Kamran, MZ, 2012) |
| "Pentoxifylline is a methylxanthine derivative with rheologic and membrane modifier property." | 5.32 | Amelioration of B16F10 melanoma cells induced oxidative stress in DBA/2 mice by pentoxifylline. ( Gude, RP; Shukla, V, 2003) |
| "Pentoxifylline (PX) is a phosphodiesterase inhibitor which effectively increases overall cAMP levels within the cell." | 5.30 | Pentoxifylline-induced modulation of melanoma cell growth, adhesion and lymphokine activated killer cell-mediated lysis. ( Alexander, CL; Edward, M; MacKie, RM, 1999) |
| "Isolated limb perfusion (ILP) with recombinant human tumor necrosis factor-alpha (rhTNF-alpha) and melphalan harbors the risk of septic shock-like syndrome." | 5.10 | Pentoxifyllin attenuates the systemic inflammatory response induced during isolated limb perfusion with recombinant human tumor necrosis factor-alpha and melphalan. ( Hohenberger, P; Kettelhack, C; Latz, E; Rezaei, AH; Schlag, PM; Schumann, R, 2003) |
| "Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor is known to inhibit the growth of various cancer cells including melanoma." | 3.83 | Pentoxifylline triggers autophagy via ER stress response that interferes with Pentoxifylline induced apoptosis in human melanoma cells. ( Dutta, RK; Ishaq, M; Khan, MA; Majumdar, S; Sharma, G; Sharma, K, 2016) |
| "Our results indicate that pentoxifylline inhibits the activity of the canonical WNT pathway in melanoma cell populations with high basal activity of this signalling." | 3.83 | Pentoxifylline Inhibits WNT Signalling in β-Cateninhigh Patient-Derived Melanoma Cell Populations. ( Chouaib, S; Czyz, M; Gajos-Michniewicz, A; Talar, B; Talar, M, 2016) |
| " Pentoxifylline (PTX), a methyl xanthine derivative, inhibits B16F10 melanoma lung homing by inhibiting F10 invasion, MMP secretion and adhesion to matrix components." | 3.74 | Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation. ( Dua, P; Gude, RP, 2008) |
| " In the present study, enhancement in the antimetastatic activity of etoposide (ETP) by encapsulation in sterically stabilized liposomes was evaluated in the murine experimental B16F10 melanoma model." | 3.72 | Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice. ( Gude, RP; Nagarsenker, MS; Rao, SG; Sant, VP, 2003) |
| "The influence of pentoxifylline on radiotoxicity was assessed by colony assay in TP53 wild-type Bell and mutant MeWo melanoma, and in TP53 wild-type 4197 and mutant 4451 squamous cell carcinoma (SCC) cell lines." | 3.70 | The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline. ( Binder, A; Böhm, L; Theron, T; Verheye-Dua, F, 2000) |
| ", 1991), we found that pentoxifylline and thalidomide potentiate each others antiangiogenic effect induced by human malignant melanoma cells in the cornea of Macaca arctoides monkeys." | 3.70 | Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration. ( Akhter, S; Ambrus, JL; Karakousis, CP; Kulaylat, M; Plavsic, L; Toumbis, CA, 2000) |
| " pentoxifylline (Px) (which also were found to release PgI2 and t-PA) inhibited human tumor implant induced angiogenesis and reduced spontaneous metastases in 3 transplantable murine tumors (Furth-Columbia Wilms' tumor in Furth-Wistar rats, C-1300 neuroblastoma in A/J mice and HM-Kim mammary carcinoma in Wistar rats) but not in the NIH adenocarcinoma in Balb/c mice." | 3.68 | Studies on tumor induced angiogenesis. ( Ambrus, CM; Ambrus, JL; Forgach, P; Halpern, J; Niswander, P; Sayyid, S; Stadler, S; Toumbis, C, 1992) |
| "Melanoma is the most common malignant skin cancer, appears indestructible and is notoriously resistant to all current modalities of cancer treatment strategies." | 1.38 | Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line. ( Gude, RP; Kamran, MZ, 2012) |
| "Pentoxifylline is a methylxanthine derivative with rheologic and membrane modifier property." | 1.32 | Amelioration of B16F10 melanoma cells induced oxidative stress in DBA/2 mice by pentoxifylline. ( Gude, RP; Shukla, V, 2003) |
| "Pentoxifylline (PX) is a phosphodiesterase inhibitor which effectively increases overall cAMP levels within the cell." | 1.30 | Pentoxifylline-induced modulation of melanoma cell growth, adhesion and lymphokine activated killer cell-mediated lysis. ( Alexander, CL; Edward, M; MacKie, RM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, CW | 1 |
| Joarder, I | 1 |
| Micieli, JA | 1 |
| Kamran, MZ | 2 |
| Gude, RP | 5 |
| Sharma, K | 1 |
| Ishaq, M | 1 |
| Sharma, G | 1 |
| Khan, MA | 1 |
| Dutta, RK | 1 |
| Majumdar, S | 1 |
| Talar, B | 1 |
| Gajos-Michniewicz, A | 1 |
| Talar, M | 1 |
| Chouaib, S | 1 |
| Czyz, M | 1 |
| Hohenberger, P | 1 |
| Latz, E | 1 |
| Kettelhack, C | 1 |
| Rezaei, AH | 1 |
| Schumann, R | 1 |
| Schlag, PM | 1 |
| Shukla, V | 1 |
| Sant, VP | 1 |
| Nagarsenker, MS | 1 |
| Rao, SG | 1 |
| Lazarczyk, M | 1 |
| Grzela, T | 1 |
| Niderla, J | 1 |
| Lazarczyk, MA | 1 |
| Milewski, L | 1 |
| Dziunycz, P | 1 |
| Skopinski, P | 1 |
| Golab, J | 1 |
| Dua, P | 1 |
| Margolin, K | 1 |
| Atkins, M | 1 |
| Sparano, J | 1 |
| Sosman, J | 1 |
| Weiss, G | 1 |
| Lotze, M | 1 |
| Doroshow, J | 1 |
| Mier, J | 1 |
| O'Boyle, K | 1 |
| Fisher, R | 1 |
| Campbell, E | 1 |
| Rubin, J | 1 |
| Federighi, D | 1 |
| Bursten, S | 1 |
| Alexander, CL | 1 |
| Edward, M | 1 |
| MacKie, RM | 1 |
| Theron, T | 1 |
| Binder, A | 1 |
| Verheye-Dua, F | 1 |
| Böhm, L | 1 |
| Binder, AB | 1 |
| Serafin, AM | 1 |
| Bohm, LJ | 1 |
| Ambrus, JL | 2 |
| Toumbis, CA | 1 |
| Karakousis, CP | 1 |
| Kulaylat, M | 1 |
| Akhter, S | 1 |
| Plavsic, L | 1 |
| Ambrus, CM | 1 |
| Forgach, P | 1 |
| Stadler, S | 1 |
| Halpern, J | 1 |
| Sayyid, S | 1 |
| Niswander, P | 1 |
| Toumbis, C | 1 |
1 review available for pentoxifylline and Melanoma
| Article | Year |
|---|---|
Treatment and prophylaxis of radiation optic neuropathy: A systematic review and meta-analysis.
Topics: Adrenal Cortex Hormones; Angiogenesis Inhibitors; Anticoagulants; Bevacizumab; Humans; Intravitreal | 2022 |
2 trials available for pentoxifylline and Melanoma
| Article | Year |
|---|---|
Pentoxifyllin attenuates the systemic inflammatory response induced during isolated limb perfusion with recombinant human tumor necrosis factor-alpha and melphalan.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Chemothera | 2003 |
Prospective randomized trial of lisofylline for the prevention of toxicities of high-dose interleukin 2 therapy in advanced renal cancer and malignant melanoma.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Dose-Response Relationship, Drug; | 1997 |
13 other studies available for pentoxifylline and Melanoma
| Article | Year |
|---|---|
Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Humans | 2013 |
Pentoxifylline triggers autophagy via ER stress response that interferes with Pentoxifylline induced apoptosis in human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein 5; Calcium; Calcium Chelating | 2016 |
Pentoxifylline Inhibits WNT Signalling in β-Cateninhigh Patient-Derived Melanoma Cell Populations.
Topics: beta Catenin; Cells, Cultured; Humans; Melanoma; Pentoxifylline; Platelet Aggregation Inhibitors; Wn | 2016 |
Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Prol | 2012 |
Amelioration of B16F10 melanoma cells induced oxidative stress in DBA/2 mice by pentoxifylline.
Topics: Animals; Glutathione; Glutathione Transferase; Melanoma; Mice; Mice, Inbred DBA; Oxidative Stress; P | 2003 |
Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; E | 2003 |
Differential influence of pentoxifylline on murine colon adenocarcinoma- and melanoma-derived metastatic tumor development in lungs.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Lung Neoplasms; Melanoma; Mice; Mice, Inbred BALB C; Pen | 2004 |
Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation.
Topics: Actins; Animals; Cell Movement; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GTPase-Acti | 2008 |
Pentoxifylline-induced modulation of melanoma cell growth, adhesion and lymphokine activated killer cell-mediated lysis.
Topics: Cell Adhesion; Cell Division; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; H | 1999 |
The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline.
Topics: Apoptosis; Carcinoma, Squamous Cell; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Radiat | 2000 |
Abrogation of G(2)/M-phase block enhances the cytotoxicity of daunorubicin, melphalan and cisplatin in TP53 mutant human tumor cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cel | 2000 |
Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Cornea; Corneal Neovascularization; Drug Combinat | 2000 |
Studies on tumor induced angiogenesis.
Topics: Adenocarcinoma; Aminocaproic Acid; Animals; Cornea; Ditiocarb; Humans; Kidney Neoplasms; Macaca; Mam | 1992 |