pentoxifylline has been researched along with Malignant Melanoma in 16 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor is known to inhibit the growth of various cancer cells including melanoma." | 7.83 | Pentoxifylline triggers autophagy via ER stress response that interferes with Pentoxifylline induced apoptosis in human melanoma cells. ( Dutta, RK; Ishaq, M; Khan, MA; Majumdar, S; Sharma, G; Sharma, K, 2016) |
| "Our results indicate that pentoxifylline inhibits the activity of the canonical WNT pathway in melanoma cell populations with high basal activity of this signalling." | 7.83 | Pentoxifylline Inhibits WNT Signalling in β-Cateninhigh Patient-Derived Melanoma Cell Populations. ( Chouaib, S; Czyz, M; Gajos-Michniewicz, A; Talar, B; Talar, M, 2016) |
| " Pentoxifylline (PTX), a methyl xanthine derivative, inhibits B16F10 melanoma lung homing by inhibiting F10 invasion, MMP secretion and adhesion to matrix components." | 7.74 | Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation. ( Dua, P; Gude, RP, 2008) |
| "The influence of pentoxifylline on radiotoxicity was assessed by colony assay in TP53 wild-type Bell and mutant MeWo melanoma, and in TP53 wild-type 4197 and mutant 4451 squamous cell carcinoma (SCC) cell lines." | 7.70 | The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline. ( Binder, A; Böhm, L; Theron, T; Verheye-Dua, F, 2000) |
| "Melanoma is the most common malignant skin cancer, appears indestructible and is notoriously resistant to all current modalities of cancer treatment strategies." | 5.38 | Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line. ( Gude, RP; Kamran, MZ, 2012) |
| "Pentoxifylline is a methylxanthine derivative with rheologic and membrane modifier property." | 5.32 | Amelioration of B16F10 melanoma cells induced oxidative stress in DBA/2 mice by pentoxifylline. ( Gude, RP; Shukla, V, 2003) |
| "Pentoxifylline (PX) is a phosphodiesterase inhibitor which effectively increases overall cAMP levels within the cell." | 5.30 | Pentoxifylline-induced modulation of melanoma cell growth, adhesion and lymphokine activated killer cell-mediated lysis. ( Alexander, CL; Edward, M; MacKie, RM, 1999) |
| "Isolated limb perfusion (ILP) with recombinant human tumor necrosis factor-alpha (rhTNF-alpha) and melphalan harbors the risk of septic shock-like syndrome." | 5.10 | Pentoxifyllin attenuates the systemic inflammatory response induced during isolated limb perfusion with recombinant human tumor necrosis factor-alpha and melphalan. ( Hohenberger, P; Kettelhack, C; Latz, E; Rezaei, AH; Schlag, PM; Schumann, R, 2003) |
| "Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor is known to inhibit the growth of various cancer cells including melanoma." | 3.83 | Pentoxifylline triggers autophagy via ER stress response that interferes with Pentoxifylline induced apoptosis in human melanoma cells. ( Dutta, RK; Ishaq, M; Khan, MA; Majumdar, S; Sharma, G; Sharma, K, 2016) |
| "Our results indicate that pentoxifylline inhibits the activity of the canonical WNT pathway in melanoma cell populations with high basal activity of this signalling." | 3.83 | Pentoxifylline Inhibits WNT Signalling in β-Cateninhigh Patient-Derived Melanoma Cell Populations. ( Chouaib, S; Czyz, M; Gajos-Michniewicz, A; Talar, B; Talar, M, 2016) |
| " Pentoxifylline (PTX), a methyl xanthine derivative, inhibits B16F10 melanoma lung homing by inhibiting F10 invasion, MMP secretion and adhesion to matrix components." | 3.74 | Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation. ( Dua, P; Gude, RP, 2008) |
| " In the present study, enhancement in the antimetastatic activity of etoposide (ETP) by encapsulation in sterically stabilized liposomes was evaluated in the murine experimental B16F10 melanoma model." | 3.72 | Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice. ( Gude, RP; Nagarsenker, MS; Rao, SG; Sant, VP, 2003) |
| "The influence of pentoxifylline on radiotoxicity was assessed by colony assay in TP53 wild-type Bell and mutant MeWo melanoma, and in TP53 wild-type 4197 and mutant 4451 squamous cell carcinoma (SCC) cell lines." | 3.70 | The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline. ( Binder, A; Böhm, L; Theron, T; Verheye-Dua, F, 2000) |
| ", 1991), we found that pentoxifylline and thalidomide potentiate each others antiangiogenic effect induced by human malignant melanoma cells in the cornea of Macaca arctoides monkeys." | 3.70 | Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration. ( Akhter, S; Ambrus, JL; Karakousis, CP; Kulaylat, M; Plavsic, L; Toumbis, CA, 2000) |
| " pentoxifylline (Px) (which also were found to release PgI2 and t-PA) inhibited human tumor implant induced angiogenesis and reduced spontaneous metastases in 3 transplantable murine tumors (Furth-Columbia Wilms' tumor in Furth-Wistar rats, C-1300 neuroblastoma in A/J mice and HM-Kim mammary carcinoma in Wistar rats) but not in the NIH adenocarcinoma in Balb/c mice." | 3.68 | Studies on tumor induced angiogenesis. ( Ambrus, CM; Ambrus, JL; Forgach, P; Halpern, J; Niswander, P; Sayyid, S; Stadler, S; Toumbis, C, 1992) |
| "Melanoma is the most common malignant skin cancer, appears indestructible and is notoriously resistant to all current modalities of cancer treatment strategies." | 1.38 | Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line. ( Gude, RP; Kamran, MZ, 2012) |
| "Pentoxifylline is a methylxanthine derivative with rheologic and membrane modifier property." | 1.32 | Amelioration of B16F10 melanoma cells induced oxidative stress in DBA/2 mice by pentoxifylline. ( Gude, RP; Shukla, V, 2003) |
| "Pentoxifylline (PX) is a phosphodiesterase inhibitor which effectively increases overall cAMP levels within the cell." | 1.30 | Pentoxifylline-induced modulation of melanoma cell growth, adhesion and lymphokine activated killer cell-mediated lysis. ( Alexander, CL; Edward, M; MacKie, RM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, CW | 1 |
| Joarder, I | 1 |
| Micieli, JA | 1 |
| Kamran, MZ | 2 |
| Gude, RP | 5 |
| Sharma, K | 1 |
| Ishaq, M | 1 |
| Sharma, G | 1 |
| Khan, MA | 1 |
| Dutta, RK | 1 |
| Majumdar, S | 1 |
| Talar, B | 1 |
| Gajos-Michniewicz, A | 1 |
| Talar, M | 1 |
| Chouaib, S | 1 |
| Czyz, M | 1 |
| Hohenberger, P | 1 |
| Latz, E | 1 |
| Kettelhack, C | 1 |
| Rezaei, AH | 1 |
| Schumann, R | 1 |
| Schlag, PM | 1 |
| Shukla, V | 1 |
| Sant, VP | 1 |
| Nagarsenker, MS | 1 |
| Rao, SG | 1 |
| Lazarczyk, M | 1 |
| Grzela, T | 1 |
| Niderla, J | 1 |
| Lazarczyk, MA | 1 |
| Milewski, L | 1 |
| Dziunycz, P | 1 |
| Skopinski, P | 1 |
| Golab, J | 1 |
| Dua, P | 1 |
| Margolin, K | 1 |
| Atkins, M | 1 |
| Sparano, J | 1 |
| Sosman, J | 1 |
| Weiss, G | 1 |
| Lotze, M | 1 |
| Doroshow, J | 1 |
| Mier, J | 1 |
| O'Boyle, K | 1 |
| Fisher, R | 1 |
| Campbell, E | 1 |
| Rubin, J | 1 |
| Federighi, D | 1 |
| Bursten, S | 1 |
| Alexander, CL | 1 |
| Edward, M | 1 |
| MacKie, RM | 1 |
| Theron, T | 1 |
| Binder, A | 1 |
| Verheye-Dua, F | 1 |
| Böhm, L | 1 |
| Binder, AB | 1 |
| Serafin, AM | 1 |
| Bohm, LJ | 1 |
| Ambrus, JL | 2 |
| Toumbis, CA | 1 |
| Karakousis, CP | 1 |
| Kulaylat, M | 1 |
| Akhter, S | 1 |
| Plavsic, L | 1 |
| Ambrus, CM | 1 |
| Forgach, P | 1 |
| Stadler, S | 1 |
| Halpern, J | 1 |
| Sayyid, S | 1 |
| Niswander, P | 1 |
| Toumbis, C | 1 |
1 review available for pentoxifylline and Malignant Melanoma
| Article | Year |
|---|---|
Treatment and prophylaxis of radiation optic neuropathy: A systematic review and meta-analysis.
Topics: Adrenal Cortex Hormones; Angiogenesis Inhibitors; Anticoagulants; Bevacizumab; Humans; Intravitreal | 2022 |
2 trials available for pentoxifylline and Malignant Melanoma
| Article | Year |
|---|---|
Pentoxifyllin attenuates the systemic inflammatory response induced during isolated limb perfusion with recombinant human tumor necrosis factor-alpha and melphalan.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Chemothera | 2003 |
Prospective randomized trial of lisofylline for the prevention of toxicities of high-dose interleukin 2 therapy in advanced renal cancer and malignant melanoma.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Dose-Response Relationship, Drug; | 1997 |
13 other studies available for pentoxifylline and Malignant Melanoma
| Article | Year |
|---|---|
Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Humans | 2013 |
Pentoxifylline triggers autophagy via ER stress response that interferes with Pentoxifylline induced apoptosis in human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein 5; Calcium; Calcium Chelating | 2016 |
Pentoxifylline Inhibits WNT Signalling in β-Cateninhigh Patient-Derived Melanoma Cell Populations.
Topics: beta Catenin; Cells, Cultured; Humans; Melanoma; Pentoxifylline; Platelet Aggregation Inhibitors; Wn | 2016 |
Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Prol | 2012 |
Amelioration of B16F10 melanoma cells induced oxidative stress in DBA/2 mice by pentoxifylline.
Topics: Animals; Glutathione; Glutathione Transferase; Melanoma; Mice; Mice, Inbred DBA; Oxidative Stress; P | 2003 |
Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; E | 2003 |
Differential influence of pentoxifylline on murine colon adenocarcinoma- and melanoma-derived metastatic tumor development in lungs.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Lung Neoplasms; Melanoma; Mice; Mice, Inbred BALB C; Pen | 2004 |
Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation.
Topics: Actins; Animals; Cell Movement; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; GTPase-Acti | 2008 |
Pentoxifylline-induced modulation of melanoma cell growth, adhesion and lymphokine activated killer cell-mediated lysis.
Topics: Cell Adhesion; Cell Division; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; H | 1999 |
The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline.
Topics: Apoptosis; Carcinoma, Squamous Cell; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Radiat | 2000 |
Abrogation of G(2)/M-phase block enhances the cytotoxicity of daunorubicin, melphalan and cisplatin in TP53 mutant human tumor cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cel | 2000 |
Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Cornea; Corneal Neovascularization; Drug Combinat | 2000 |
Studies on tumor induced angiogenesis.
Topics: Adenocarcinoma; Aminocaproic Acid; Animals; Cornea; Ditiocarb; Humans; Kidney Neoplasms; Macaca; Mam | 1992 |