pentoxifylline has been researched along with Liver Neoplasms in 12 studies
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentoxifylline (PTX) has been reported to have both direct and indirect anti-tumor effects in experimental tumor models." | 5.30 | The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma. ( Amirkhosravi, A; Biggerstaff, J; Francis, JL; Malik, Z; May, K; Warnes, G, 1997) |
| "To investigate the effects of pentoxifylline (PTX) on radiation induced-cell cycle redistribution and radiosensitivity of human hepatocellular carcinoma cell line Hep3b." | 3.73 | [Cytotoxicity of pentoxifylline and its effect on human hepatoma cell line Hep3b radiosensitivity]. ( Chen, LH; Liu, L; Wu, DH, 2006) |
| " 22 adverse events of any grade likely or certainly related to PTX were recorded in 12 patients leading to the discontinuation of the study medication in 7 patients and to a dose reduction of PTX in 2 patients." | 3.30 | Prevention of radiation-induced liver toxicity after interstitial HDR brachytherapy by pentoxifylline and ursodeoxycholic acid: patient compliance and outcome in a randomized trial. ( Damm, R; Hass, P; Omari, J; Pech, M; Ricke, J; Seidensticker, M; Seidensticker, R; Walke, M; Wybranska, J, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) defines fat accumulation in the liver, and it is commonly associated with metabolic syndromes like diabetes and obesity." | 2.82 | A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases. ( Ezhilarasan, D; Lakshmi, T, 2022) |
| "Patients with liver metastases from colorectal carcinoma who were scheduled for local ablation by radiotherapy (image-guided high-dose-rate interstitial brachytherapy) were prospectively randomized to receive PTX, UDCA and LMWH for 8 weeks (treatment) or no medication (control)." | 2.79 | Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity. ( Damm, R; Gademann, G; Hass, P; Kropf, S; Mohnike, K; Pech, M; Ricke, J; Sangro, B; Seidensticker, M; Seidensticker, R; Wust, P, 2014) |
| "RNA sequencing of primary colorectal cancer specimens vs adjacent liver tissue vs synchronous and asynchronous liver metastases." | 1.91 | Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids. ( Blandino, G; Canu, V; Caricato, M; Cioce, M; Crescenzi, A; Diodoro, MG; Donzelli, S; Fanciulli, M; Fazio, VM; Fumagalli, MR; Goeman, F; Grazi, GL; La Porta, C; Levrero, M; Morrone, A; Orlandi, G; Palcau, AC; Pulito, C; Rutigliano, D; Sacconi, A; Strano, S; Verri, M; Zapperi, S, 2023) |
| "Pentoxifylline (PTX) is a methylxanthine derivative and has potent anti-tumor activity." | 1.46 | Pentoxifylline induces apoptosis of HepG2 cells by reducing reactive oxygen species production and activating the MAPK signaling. ( Dong, L; Li, J; Luo, M; Shang, B; Wang, Y, 2017) |
| "Pentoxifylline (PTX) has been reported to have both direct and indirect anti-tumor effects in experimental tumor models." | 1.30 | The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma. ( Amirkhosravi, A; Biggerstaff, J; Francis, JL; Malik, Z; May, K; Warnes, G, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ezhilarasan, D | 1 |
| Lakshmi, T | 1 |
| Damm, R | 2 |
| Wybranska, J | 1 |
| Hass, P | 2 |
| Walke, M | 1 |
| Omari, J | 1 |
| Pech, M | 2 |
| Seidensticker, R | 2 |
| Ricke, J | 2 |
| Seidensticker, M | 2 |
| Cioce, M | 1 |
| Fumagalli, MR | 1 |
| Donzelli, S | 1 |
| Goeman, F | 1 |
| Canu, V | 1 |
| Rutigliano, D | 1 |
| Orlandi, G | 1 |
| Sacconi, A | 1 |
| Pulito, C | 1 |
| Palcau, AC | 1 |
| Fanciulli, M | 1 |
| Morrone, A | 1 |
| Diodoro, MG | 1 |
| Caricato, M | 1 |
| Crescenzi, A | 1 |
| Verri, M | 1 |
| Fazio, VM | 1 |
| Zapperi, S | 1 |
| Levrero, M | 1 |
| Strano, S | 1 |
| Grazi, GL | 1 |
| La Porta, C | 1 |
| Blandino, G | 1 |
| Wang, Y | 1 |
| Dong, L | 1 |
| Li, J | 1 |
| Luo, M | 1 |
| Shang, B | 1 |
| Jiménez-Luévano, MÁ | 1 |
| Rodríguez-Chávez, JL | 1 |
| Ramírez-Flores, S | 1 |
| Rodríguez-Villa, P | 1 |
| Jiménez-Partida, MÁ | 1 |
| Cervantes-Rodríguez, G | 1 |
| Hernández-Flores, G | 1 |
| Solís-Martínez, R | 1 |
| Bravo-Cuellar, A | 1 |
| Mohnike, K | 1 |
| Sangro, B | 1 |
| Wust, P | 1 |
| Kropf, S | 1 |
| Gademann, G | 1 |
| Jang, MS | 1 |
| Baek, JW | 1 |
| Kang, DY | 1 |
| Kang, JS | 1 |
| Suh, KS | 1 |
| Kim, ST | 1 |
| Wu, DH | 2 |
| Liu, L | 2 |
| Chen, LH | 2 |
| Amirkhosravi, A | 1 |
| Warnes, G | 1 |
| Biggerstaff, J | 1 |
| Malik, Z | 1 |
| May, K | 1 |
| Francis, JL | 1 |
| Wördemann, M | 1 |
| Fandrey, J | 1 |
| Jelkmann, W | 1 |
| Koppenhagen, K | 1 |
| Wenig, HG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity After Brachytherapy of Liver Metastases From Colorectal Carcinoma, Assessed in a Prospective Randomised Trial[NCT01149304] | Phase 2 | 22 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pentoxifylline and Liver Neoplasms
| Article | Year |
|---|---|
A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases.
Topics: Antioxidants; Humans; Liver; Liver Neoplasms; NF-kappa B; Non-alcoholic Fatty Liver Disease; Pentoxi | 2022 |
3 trials available for pentoxifylline and Liver Neoplasms
| Article | Year |
|---|---|
Prevention of radiation-induced liver toxicity after interstitial HDR brachytherapy by pentoxifylline and ursodeoxycholic acid: patient compliance and outcome in a randomized trial.
Topics: Brachytherapy; Humans; Liver Neoplasms; Patient Compliance; Pentoxifylline; Radiotherapy Dosage; Urs | 2023 |
Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity.
Topics: Aged; Aged, 80 and over; Brachytherapy; Colorectal Neoplasms; Enoxaparin; Female; Humans; Liver Neop | 2014 |
[The effect of pentoxifylline on liver perfusion: a comparative study in patients with liver diseases and in normal subjects, using 198Au-colloid-scintigraphy (author's transl)].
Topics: Adult; Aged; Chronic Disease; Female; Hepatitis; Humans; Liver; Liver Circulation; Liver Cirrhosis; | 1979 |
8 other studies available for pentoxifylline and Liver Neoplasms
| Article | Year |
|---|---|
Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids.
Topics: Colorectal Neoplasms; Fluorouracil; Humans; Interleukin-6; Liver Neoplasms; Organoids; Pentoxifyllin | 2023 |
Pentoxifylline induces apoptosis of HepG2 cells by reducing reactive oxygen species production and activating the MAPK signaling.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Prolif | 2017 |
Treatment of hepatocarcinoma with celecoxib and pentoxifylline: a case report
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Ce | 2018 |
Supraumbilical skin rash after transcatheter arterial chemoembolization: successful treatment with pentoxifylline.
Topics: Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Exanthema; Female; Hepatic Artery; Humans | 2011 |
[Radiosensitization by pentoxifylline in human hepatoma cell line HepG2 and its mechanism].
Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Line, Tumor; DNA Damage; Genes, p53; Huma | 2004 |
[Cytotoxicity of pentoxifylline and its effect on human hepatoma cell line Hep3b radiosensitivity].
Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; D | 2006 |
The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma.
Topics: Animals; Carcinogenicity Tests; Cell Adhesion; Cell Cycle; Cell Division; Cell Membrane; Female; Fib | 1997 |
Tumor necrosis factor-alpha production by human hepatoma cell lines is resistant to drugs that are inhibitory to macrophages.
Topics: Adjuvants, Immunologic; Carcinoma, Hepatocellular; Cyclosporine; Drug Resistance, Neoplasm; Humans; | 1998 |