pentoxifylline has been researched along with Leg Ulcer in 43 studies
Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, placebo-controlled study was carried out in 12 patients suffering from chronic venous insufficiency and persistent leg ulcers to assess the efficacy of pentoxifylline treatment as an adjunct to compression bandaging in the conservative management of venous leg ulcers." | 9.07 | Pentoxifylline in the treatment of venous leg ulcers. ( Barbarino, C, 1992) |
| "The possible healing effect of deferoxamine and pentoxifylline on persisting lower limb ulcers was studied in 51 patients with thalassemia major." | 9.07 | Effect of pentoxifylline on treatment of lower limb ulcers in patients with thalassemia major. ( Angastiniotis, C; Angelides, NS; Pavlides, N, 1992) |
| "To assess the effects of pentoxifylline (oxpentifylline or Trental 400) for treating venous leg ulcers, compared with a placebo or other therapies, in the presence or absence of compression therapy." | 8.88 | Pentoxifylline for treating venous leg ulcers. ( Arroll, B; Jull, AB; Parag, V; Waters, J, 2012) |
| "To assess the effects of pentoxifylline (oxpentifylline or Trental 400) for treating venous leg ulcers, compared with placebo, or other therapies, in the presence or absence of compression therapy." | 8.84 | Pentoxifylline for treating venous leg ulcers. ( Arroll, B; Jull, A; Parag, V; Waters, J, 2007) |
| "To assess the effects of pentoxifylline (oxpentifylline or Trental 400) for treating venous leg ulcers, compared with placebo, or other therapies, in the presence or absence of compression therapy." | 8.81 | Pentoxifylline for treating venous leg ulcers. ( Arroll, B; Jull, AB; Waters, J, 2002) |
| " We did a systematic review of randomised controlled trials that compared pentoxifylline (with and without compression treatment) with placebo, or other treatments, in patients with venous leg ulcers." | 8.81 | Pentoxifylline for treatment of venous leg ulcers: a systematic review. ( Arroll, B; Jull, A; Waters, J, 2002) |
| "To assess the effects of pentoxifylline ('Trental 400') for treating venous leg ulcers, when compared with placebo, or in comparison with other therapies, in the presence or absence of compression therapy." | 8.80 | Oral pentoxifylline for treatment of venous leg ulcers. ( Arroll, B; Jull, AB; Waters, J, 2000) |
| "A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months." | 7.68 | Treatment of sickle cell leg ulcers with pentoxifylline. ( Frost, ML; Treadwell, P, 1990) |
| " We describe a patient with bilateral ischemic leg ulcers treated preoperatively with pentoxifylline." | 7.68 | Treatment of ischemic leg ulcers with pentoxifylline: a case report and theoretical considerations. ( Fahey, MJ; Velanovich, V, 1990) |
| " If confirmed, it wound offer another effective and safe therapeutic option for treatment of VLUs." | 7.30 | Efficacy and safety of pentoxifylline for chronic venous leg ulcers: study protocol for a multicenter randomized controlled trial in China (ESPECT study). ( Chen, L; Dai, Y; Gao, Y; Han, C; Li, B; Li, J; Li, P; Li, Q; Li, Y; Liu, M; Ran, X; Xu, J; Zhao, Y, 2023) |
| "A factorial randomized controlled trial with 24-week follow-up was conducted in leg ulcer clinics in Scotland with blinded allocation to pentoxifylline (1200 mg) or placebo, knitted viscose or hydrocolloid dressings, and single-layer or four-layer bandages." | 5.12 | A factorial, randomized trial of pentoxifylline or placebo, four-layer or single-layer compression, and knitted viscose or hydrocolloid dressings for venous ulcers. ( Brown, D; Gibson, B; Harper, DR; Nelson, EA; Prescott, RJ; Ruckley, CV, 2007) |
| "A double-blind, placebo-controlled study was carried out in 12 patients suffering from chronic venous insufficiency and persistent leg ulcers to assess the efficacy of pentoxifylline treatment as an adjunct to compression bandaging in the conservative management of venous leg ulcers." | 5.07 | Pentoxifylline in the treatment of venous leg ulcers. ( Barbarino, C, 1992) |
| "The possible healing effect of deferoxamine and pentoxifylline on persisting lower limb ulcers was studied in 51 patients with thalassemia major." | 5.07 | Effect of pentoxifylline on treatment of lower limb ulcers in patients with thalassemia major. ( Angastiniotis, C; Angelides, NS; Pavlides, N, 1992) |
| "To assess the effects of pentoxifylline (oxpentifylline or Trental 400) for treating venous leg ulcers, compared with a placebo or other therapies, in the presence or absence of compression therapy." | 4.88 | Pentoxifylline for treating venous leg ulcers. ( Arroll, B; Jull, AB; Parag, V; Waters, J, 2012) |
| "To assess the effects of pentoxifylline (oxpentifylline or Trental 400) for treating venous leg ulcers, compared with placebo, or other therapies, in the presence or absence of compression therapy." | 4.84 | Pentoxifylline for treating venous leg ulcers. ( Arroll, B; Jull, A; Parag, V; Waters, J, 2007) |
| "Ten patients with venous leg ulcers and 10 patients with mixed venous/arterial ulcers were investigated with LDF, tcpO2, and LDA before and after injection of prostaglandin E1 and pentoxifylline." | 3.72 | Capillary blood cell velocity in periulcerous regions of the lower leg measured by laser Doppler anemometry. ( Altmeyer, P; Bechara, FG; Hoffmann, K; Huntermann, C; Stücker, M, 2004) |
| "A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months." | 3.68 | Treatment of sickle cell leg ulcers with pentoxifylline. ( Frost, ML; Treadwell, P, 1990) |
| " We describe a patient with bilateral ischemic leg ulcers treated preoperatively with pentoxifylline." | 3.68 | Treatment of ischemic leg ulcers with pentoxifylline: a case report and theoretical considerations. ( Fahey, MJ; Velanovich, V, 1990) |
| "In an open field study, 70 patients with leg ulcers, some existing already for a long time, were treated with Pentoxifylline in addition to the hitherto applied local therapy." | 3.66 | [Trental forte in leg ulcer therapy. Result of a field study]. ( Schmidt-Modrow, G; Weitgasser, H, 1982) |
| " If confirmed, it wound offer another effective and safe therapeutic option for treatment of VLUs." | 3.30 | Efficacy and safety of pentoxifylline for chronic venous leg ulcers: study protocol for a multicenter randomized controlled trial in China (ESPECT study). ( Chen, L; Dai, Y; Gao, Y; Han, C; Li, B; Li, J; Li, P; Li, Q; Li, Y; Liu, M; Ran, X; Xu, J; Zhao, Y, 2023) |
| "The lower legs of homozygous sickle cell anemia patients are areas of marginal vascularity where minor abrasions become foci of inflammation." | 2.40 | [Falciform anemia and Plasmodium falciparum malaria: a threat to flap survival?]. ( Humbert, J; Loutan, L; Mariéthoz, S; Montandon, D; Pittet, B, 1999) |
| "Pyoderma gangrenosum is most commonly treated with immunosuppressants or anti-inflammatory agents and is often worsened by surgical procedures due to the presence of pathergy." | 1.48 | Improvement of Ulcerations in Treatment-Resistant Chronic Scarring in a Patient with Pyoderma Gangrenosum After Improving Vascular Insufficiency, Gently Removing Necrotic Debris, and Decreasing Wound Fluid. ( Gordon, C; Hizon, BJ; Mota, JA; Nahm, WJ; Rojas, S, 2018) |
| "Cutaneous polyarteritis nodosa (CPAN) is a self-limited cutaneous vasculitis characterized by painful nodules, affecting mostly the lower limbs, and livedo reticularis." | 1.37 | Ulcerative cutaneous polyarteritis nodosa treated with mycophenolate mofetil and pentoxifylline. ( Bessis, D; Guillot, B; Kluger, N, 2011) |
| "Calciphylaxis is a rare syndrome developing predominantly in female patients suffering from end-stage renal disease (ESRD) with secondary hyperparathyroidism." | 1.31 | Painful ulcers in calciphylaxis - combined treatment with maggot therapy and oral pentoxyfillin. ( Graefe, T; Tittelbach, J; Wollina, U, 2001) |
| "Pentoxifylline (Trental) has multiple mechanisms of action, including stimulation of prostacyclin synthesis, decreased aggregation of platelets, increased deformability of red blood cells, increased mobility of neutrophils, and increased fibrinolysis." | 1.27 | Therapy of livedo vasculitis with pentoxifylline. ( Bard, JW; Ely, H, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (16.28) | 18.7374 |
| 1990's | 14 (32.56) | 18.2507 |
| 2000's | 13 (30.23) | 29.6817 |
| 2010's | 8 (18.60) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L | 1 |
| Gao, Y | 1 |
| Liu, M | 1 |
| Li, Q | 1 |
| Han, C | 1 |
| Zhao, Y | 1 |
| Li, B | 1 |
| Xu, J | 1 |
| Dai, Y | 1 |
| Li, P | 1 |
| Li, J | 1 |
| Li, Y | 1 |
| Ran, X | 1 |
| Nelson, EA | 3 |
| Adderley, U | 1 |
| Vietto, V | 1 |
| Franco, JV | 1 |
| Saenz, V | 1 |
| Cytryn, D | 1 |
| Chas, J | 1 |
| Ciapponi, A | 1 |
| Nahm, WJ | 1 |
| Mota, JA | 1 |
| Rojas, S | 1 |
| Hizon, BJ | 1 |
| Gordon, C | 1 |
| Criado, PR | 1 |
| Alavi, A | 1 |
| Halpern, I | 1 |
| Sotto, MN | 1 |
| Kirsner, RS | 2 |
| Altman, IA | 1 |
| Kleinfelder, RE | 1 |
| Quigley, JG | 1 |
| Ennis, WJ | 1 |
| Minniti, CP | 1 |
| Neid, T | 1 |
| Danz, B | 1 |
| Eismann, R | 1 |
| Bramsiepe, I | 1 |
| Wohlrab, J | 1 |
| Marsch, WC | 1 |
| Fiedler, E | 1 |
| Kluger, N | 1 |
| Guillot, B | 1 |
| Bessis, D | 1 |
| Word, R | 1 |
| Jull, AB | 4 |
| Arroll, B | 6 |
| Parag, V | 2 |
| Waters, J | 6 |
| Tittelbach, J | 1 |
| Graefe, T | 1 |
| Wollina, U | 1 |
| Coleridge Smith, PD | 1 |
| Stücker, M | 1 |
| Huntermann, C | 1 |
| Bechara, FG | 1 |
| Hoffmann, K | 1 |
| Altmeyer, P | 1 |
| Trent, JT | 1 |
| Jull, A | 3 |
| Prescott, RJ | 2 |
| Harper, DR | 2 |
| Gibson, B | 2 |
| Brown, D | 1 |
| Ruckley, CV | 2 |
| Marston, W | 1 |
| Forteleoni, G | 1 |
| Pacitti, C | 1 |
| Mulas, G | 1 |
| Careddu, F | 1 |
| Antona, C | 1 |
| Luscrì, MF | 1 |
| Weitgasser, H | 1 |
| Schmidt-Modrow, G | 1 |
| Koshkin, VM | 1 |
| Bogdanets, LI | 1 |
| Makarova, LD | 1 |
| Goodfield, M | 1 |
| Kido, M | 1 |
| Tago, O | 1 |
| Fujiwara, H | 1 |
| Ito, M | 1 |
| Niwano, H | 1 |
| Mariéthoz, S | 1 |
| Pittet, B | 1 |
| Loutan, L | 1 |
| Humbert, J | 1 |
| Montandon, D | 1 |
| Chodynicka, B | 1 |
| Laudańska, H | 1 |
| Reduta, T | 1 |
| Dale, JJ | 1 |
| Pemler, K | 1 |
| Penth, B | 1 |
| Adams, HJ | 1 |
| Mund-Hoym, WD | 1 |
| Tercedor, J | 1 |
| Herranz, MT | 1 |
| Ródenas, JM | 1 |
| García-Lora, E | 1 |
| Skiljo, M | 1 |
| García-Mellado, V | 1 |
| Barbarino, C | 1 |
| Angelides, NS | 1 |
| Angastiniotis, C | 1 |
| Pavlides, N | 1 |
| Brenman, SA | 1 |
| Frost, ML | 1 |
| Treadwell, P | 1 |
| Bittiner, SB | 1 |
| Velanovich, V | 1 |
| Fahey, MJ | 1 |
| Jarcusková, D | 1 |
| Uhrík, J | 1 |
| Ely, H | 1 |
| Bard, JW | 1 |
| Brenner, MA | 1 |
16 reviews available for pentoxifylline and Leg Ulcer
| Article | Year |
|---|---|
Prostanoids for critical limb ischaemia.
Topics: Alprostadil; Amputation, Surgical; Epoprostenol; Humans; Iloprost; Ischemia; Leg; Leg Ulcer; Nafrony | 2018 |
A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease.
Topics: Administration, Oral; Administration, Topical; Algorithms; Anemia, Sickle Cell; Bandages; Combined M | 2016 |
Medical and surgical therapy for advanced chronic venous insufficiency.
Topics: Bandages; Chronic Disease; Combined Modality Therapy; Drug Therapy, Combination; Female; Humans; Leg | 2010 |
Pentoxifylline for treating venous leg ulcers.
Topics: Administration, Oral; Bandages; Combined Modality Therapy; Fibrinolytic Agents; Humans; Leg Ulcer; P | 2012 |
Deleterious effects of white cells in the course of skin damage in CVI.
Topics: Alprostadil; Cell Adhesion Molecules; Chronic Disease; Humans; Iloprost; Leg Ulcer; Leukocytes; Neut | 2002 |
Leg ulcers in sickle cell disease.
Topics: Anemia, Sickle Cell; Antisickling Agents; Bandages; Blood Transfusion; Carnitine; Debridement; Drug | 2004 |
Pentoxifylline for treating venous leg ulcers.
Topics: Administration, Oral; Bandages; Combined Modality Therapy; Humans; Leg Ulcer; Pentoxifylline; Polyde | 2007 |
Evaluation and treatment of leg ulcers associated with chronic venous insufficiency.
Topics: Chronic Disease; Humans; Laser Therapy; Leg Ulcer; Pentoxifylline; Stockings, Compression; Vasodilat | 2007 |
Optimal management of chronic leg ulcers in the elderly.
Topics: Administration, Oral; Aged; Aging; Arterial Occlusive Diseases; Aspirin; Bandages; Combined Modality | 1997 |
[Falciform anemia and Plasmodium falciparum malaria: a threat to flap survival?].
Topics: Anemia, Sickle Cell; Antisickling Agents; Child; Humans; Hydroxyurea; Leg Ulcer; Malaria, Falciparum | 1999 |
Oral pentoxifylline for treatment of venous leg ulcers.
Topics: Administration, Oral; Bandages; Humans; Leg Ulcer; Pentoxifylline; Vasodilator Agents | 2000 |
Pentoxifylline for treating venous leg ulcers.
Topics: Administration, Oral; Bandages; Humans; Leg Ulcer; Pentoxifylline; Vasodilator Agents | 2002 |
Oral pentoxifylline for treatment of venous leg ulcers.
Topics: Administration, Oral; Adult; Aged; Bandages; Combined Modality Therapy; Female; Humans; Leg Ulcer; M | 2000 |
Pentoxifylline for treatment of venous leg ulcers: a systematic review.
Topics: Administration, Oral; Bandages; Chi-Square Distribution; Humans; Leg Ulcer; Pentoxifylline; Randomiz | 2002 |
Oxpentifylline for venous leg ulcers.
Topics: Humans; Leg Ulcer; Pentoxifylline | 1991 |
Pentoxifylline as adjunctive therapy in leg ulcer management.
Topics: Adjuvants, Pharmaceutic; Adult; Aged; Aged, 80 and over; Blood Cells; Chronic Disease; Female; Human | 1991 |
6 trials available for pentoxifylline and Leg Ulcer
| Article | Year |
|---|---|
Efficacy and safety of pentoxifylline for chronic venous leg ulcers: study protocol for a multicenter randomized controlled trial in China (ESPECT study).
Topics: Humans; Leg Ulcer; Multicenter Studies as Topic; Pentoxifylline; Quality of Life; Randomized Control | 2023 |
A factorial, randomized trial of pentoxifylline or placebo, four-layer or single-layer compression, and knitted viscose or hydrocolloid dressings for venous ulcers.
Topics: Administration, Oral; Adult; Aged, 80 and over; Bandages, Hydrocolloid; Cellulose; Female; Follow-Up | 2007 |
[Application of pentoxiphylline to treatment of leg ulcers: a Polish multicenter study].
Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Humans; Leg Ulcer; Male; M | 1999 |
Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers.
Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Hematologic Agents; Humans; Leg Ulcer; | 1999 |
Pentoxifylline in the treatment of venous leg ulcers.
Topics: Aged; Bandages; Chemotherapy, Adjuvant; Chronic Disease; Double-Blind Method; Female; Humans; Leg Ul | 1992 |
Effect of pentoxifylline on treatment of lower limb ulcers in patients with thalassemia major.
Topics: Adult; Deferoxamine; Female; Humans; Leg Ulcer; Male; Pentoxifylline; Recurrence; Thalassemia | 1992 |
21 other studies available for pentoxifylline and Leg Ulcer
| Article | Year |
|---|---|
Venous Leg Ulcers.
Topics: Age Factors; Compression Bandages; Humans; Leg Ulcer; Pentoxifylline; Platelet Aggregation Inhibitor | 2017 |
Improvement of Ulcerations in Treatment-Resistant Chronic Scarring in a Patient with Pyoderma Gangrenosum After Improving Vascular Insufficiency, Gently Removing Necrotic Debris, and Decreasing Wound Fluid.
Topics: Adult; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Chronic Disease; Cicatrix; Clobetasol | 2018 |
Unilateral livedoid vasculopathy associated with involutional phase of cutaneous infantile hemangioma: the connection to coagulation disorders.
Topics: Adolescent; Aspirin; Biopsy; Blood Coagulation Disorders; Blood Coagulation Tests; Diagnosis, Differ | 2013 |
[Sclerodermiform chronic graft-versus-host disease after allogenic peripheral blood stem-cell transplantation].
Topics: Anti-Infective Agents; Cyclosporine; Graft vs Host Disease; Humans; Immunosuppressive Agents; Laser- | 2009 |
Ulcerative cutaneous polyarteritis nodosa treated with mycophenolate mofetil and pentoxifylline.
Topics: Aged; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Leg Ulcer; Mycophenolic A | 2011 |
Painful ulcers in calciphylaxis - combined treatment with maggot therapy and oral pentoxyfillin.
Topics: Administration, Oral; Animals; Calciphylaxis; Combined Modality Therapy; Female; Humans; Larva; Leg | 2001 |
Capillary blood cell velocity in periulcerous regions of the lower leg measured by laser Doppler anemometry.
Topics: Aged; Aged, 80 and over; Alprostadil; Blood Flow Velocity; Capillaries; Case-Control Studies; Erythr | 2004 |
Pentoxifylline for leg ulcers.
Topics: Austria; Denmark; Hematologic Agents; Humans; Leg Ulcer; Pentoxifylline; Randomized Controlled Trial | 2005 |
[Our experience in the treatment of malleolar ulcers in thalassemia].
Topics: Adolescent; Adult; Bandages; Blood Transfusion; Deferoxamine; Female; Humans; Leg Ulcer; Pentoxifyll | 1983 |
[Trental forte in leg ulcer therapy. Result of a field study].
Topics: Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Leg Ulcer; Male; Middle | 1982 |
[Treatment of trophic ulcers of the lower extremities with Trental-400].
Topics: Adult; Aged; Aged, 80 and over; Arterial Occlusive Diseases; Chronic Disease; Drug Evaluation; Human | 1996 |
Leg ulcer associated with hydroxyurea treatment in a patient with chronic myelogenous leukaemia: successful treatment with prostagladin E1 and pentoxifylline.
Topics: Alprostadil; Antineoplastic Agents; Humans; Hydroxyurea; Leg Ulcer; Leukemia, Myelogenous, Chronic, | 1998 |
[Pentoxifylline medication within the scope of leg-ulcer therapy. Results of a field study using Trental 400].
Topics: Administration, Oral; Aged; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Leg Ulcer; Ma | 1979 |
[The treatment of chronic arterial bloodcirculation interference (author's transl)].
Topics: Adult; Aged; Arterial Occlusive Diseases; Cholesterol; Drug Evaluation; Female; Humans; Leg; Leg Ulc | 1978 |
Pentoxifylline treatment for beta-thalassemia intermedia leg ulcer.
Topics: Adult; Ankle; beta-Thalassemia; Female; Humans; Leg Ulcer; Pentoxifylline | 1992 |
Treatment of sickle cell leg ulcers with pentoxifylline.
Topics: Anemia, Sickle Cell; Chronic Disease; Humans; Leg Ulcer; Male; Middle Aged; Pentoxifylline; Recurren | 1990 |
Oxpentifylline treatment of venous leg ulcers.
Topics: Humans; Leg Ulcer; Obesity; Pentoxifylline; Theobromine | 1990 |
Treatment of ischemic leg ulcers with pentoxifylline: a case report and theoretical considerations.
Topics: Aged; Aged, 80 and over; Female; Humans; Leg Ulcer; Pentoxifylline; Preoperative Care; Skin Transpla | 1990 |
[Evaluation of thermal conductivity and skin temperature in the treatment of leg ulcers].
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Diabetic Angiopathies; Female; Humans; Leg; Leg Ul | 1988 |
Therapy of livedo vasculitis with pentoxifylline.
Topics: Adult; Atrophy; Female; Humans; Leg Ulcer; Middle Aged; Pentoxifylline; Skin; Theobromine; Wound Hea | 1988 |
Nonhealing venous stasis ulcers. Pentoxifylline as adjunctive therapy.
Topics: Aged; Humans; Leg Ulcer; Male; Pentoxifylline; Theobromine; Venous Insufficiency | 1987 |