pentoxifylline and Injury, Ischemia-Reperfusion studies

Research Excerpts

Excerpt	Relevance	Reference
"This study aimed to assess the clinical efficacy of pentoxifylline (PTX) and L-glutamine (L-Gln) treatment on ischemia and reperfusion (I/R) injury in the abomasal tissue, acute phase response (APR), oxidative stress (OS), cytokine response, hemostatic, and coagulation disorders in the 96-h period before and after surgery in displaced abomasum (DA) cases."	8.02	The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study. ( Arican, M; Çöl, R; Ider, M; Maden, M; Parlak, K; Tras, B; Yildiz, R, 2021)
"This study was designed to investigate the effects of separate and combined administration of hypothermia and pentoxifylline to preserve the effects on the testicles in an experimental model of testicular torsion/ detorsion injuries in rats."	8.02	Effects of hypothermia and pentoxifylline on the adnexal torsion/detorsion injuries in a rat testis model. ( Abtahi-Eivary, SH; Brazvan, B; Elmimehr, R; Fani, M; Moghimian, M; Motamed-Sanaye, A, 2021)
"Our findings demonstrate that pentoxifylline may be promising in preventing small bowel ischemia-reperfusion injury."	7.88	Role of pentoxifylline and iloprost in the prevention of ischemia-reperfusion injury in an experimental model of intestine ischemia-reperfusion in rats. ( Abakay, U; Çakmak, E; Genç, HÇ; Göksel, S; Korkmaz, Ö; Kurt, A; Şahin İnan, ZD; Saraç, B; Soylu, S, 2018)
"Ischemic preconditioning or pentoxifylline alone protect the intestinal mucosa from ischemia/reperfusion injury."	7.85	The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats. ( Fagundes, DJ; Monteiro, HP; Oliveira, GF; Oliveira, TRR; Simões, RS; Taha, MO; Tikazawa, EH, 2017)
"We studied the new anti-inflammatory effects of non-specific phosphodiesterase (PDE) inhibitor pentoxifylline (PTX) on ischaemia-reperfusion injury and postconditioning of the lower extremities."	7.85	Pentoxifylline attenuates the local and systemic inflammatory response after infrarenal abdominal aortic ischemia-reperfusion. ( Arató, E; Fazekas, G; Hardi, P; Jancsó, G; Nagy, T; Petrovics, L; Pintér, Ö; Sínay, L; Takács, I; Tóth, M, 2017)
"The combination of lidocaine, methylene blue and pentoxyphylline administered intraperitoneally at the studied dose, did not decreased histological lesion scores and biochemical markers levels in intestinal ischemia/reperfusion injury."	7.83	Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats. ( Cerri, S; Farca, AM; Gandini, M; Giusto, G; Iussich, S; Pregel, P; Tursi, M; Vercelli, C, 2016)
"To investigate the action of pentoxifylline (PTX) and prostaglandin E1 (PGE1) on ischemia and reperfusion of small intestine tissue in rats, using immunohistochemical analysis."	7.81	Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small intestine tissue in rats. An immunohistochemical study. ( Assis, PV; Aydos, RD; Brasileiro, JL; Marks, G; Ramalho, RT; Silva, IS; Takita, LC, 2015)
" Since Pentoxifylline, a methyl-xanthine derivative known for enhancement of vascular endothelial function, down-regulation of many inflammatory cytokines increased during preeclampsia, improvement of placental circulation, reduction of ischemia-reperfusion injury, enhancement of vasodilatation and endothelial function, ameliorating proteinuria, inhibition of platelet aggregation and decreasing risk of preterm labor, which are all amongst morbidities of preeclampsia, here it is hypothesized that Pentoxifylline prevents development of preeclampsia and/or decelerate progression of the disease."	7.81	Hypothesis: Pentoxifylline explores new horizons in treatment of preeclampsia. ( Azimi, A; Farhadi, P; Sagheb, MM; Ziaee, SM, 2015)
"To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline."	7.80	Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats. ( Belon, AR; Carvalho, JG; Felice Neto, R; Marques, GM; Montero, EF; Rasslan, R; Rasslan, S; Utiyama, EM, 2014)
"These results indicate pentoxifylline diminishes leukocyte-endothelium interaction, and may have a therapeutic role in preventing ischemia reperfusion injury in microsurgical operations."	7.74	In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury. ( Dalcik, H; Iscen, D; Sen, C; Unal, C, 2007)
" We are of the opinion that in the early phase of skeletal muscle ischemia, iloprost and pentoxifylline medication may reduce ischemia-reperfusion injury."	7.74	Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model. ( Aksun, M; Bozok, S; Emrecan, B; Gürbüz, A; Ozcan, AV; Saçar, M; Tulukoğlu, E; Yağdi, S, 2008)
"Pentoxifylline, when administered to recipient animals, attenuates reperfusion injury to a degree similar to that seen with leukocyte-depleted reperfusion."	7.72	Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury. ( Clark, SC; Dark, JH; Flecknell, PA; Rao, JN, 2003)
"We examined whether pentoxifylline (PTX) and coenzyme Q10 (Q) pretreatment affect ischemia-reperfusion damage in the rat liver."	7.70	Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury. ( Inal-Erden, M; Portakal, O, 1999)
"This study was designed to clarify the effects of pentoxifylline (PTX) and N-acetylcysteine (NAC) on hepatic reperfusion injury in rats."	7.70	Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury. ( Demir, S; Inal-Erden, M, 1998)
"Previous studies have suggested reductions in lung reperfusion injury with pentoxifylline, inositol polyanions, and the nitric oxide donor, SIN-1, but these agents have never been directly compared to ascertain which is superior."	7.70	Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1. ( Clark, SC; Dark, JH; Flecknell, PA; Roughan, J; Sudarshan, C, 1999)
"In an effort to determine whether treatment with lisofylline (LSF) ameliorates intestinal barrier dysfunction in rats subjected to mesenteric ischemia and reperfusion (I/R), regional mesenteric vessels were occluded for 60 min and then unclamped for 60 min more."	7.70	Lisofylline ameliorates intestinal mucosal barrier dysfunction caused by ischemia and ischemia/reperfusion. ( Delude, RL; Fink, MP; Menconi, MJ; Wattanasirichaigoon, S, 1999)
"The aim of this study was to determine the effects of pentoxifylline (Ptx) in reperfusion injury of the small bowel as a leukocyte stabilizer, free radical scavenger, and microcirculatory regulator."	7.69	Pentoxifylline inhibits overflow and reduces intestinal reperfusion injury. ( Aras, T; Ataoğlu, O; Bilgehan, A; Cakmak, M; Dindar, H; Ozgüner, F; Savaş, C; Türközkan, N; Yücesan, S, 1997)
"Placebo and pentoxifylline were given to eight groups of rats prior to priapism being induced by a vacuum constrictive device for durations of 6 and 12 h, respectively."	7.69	Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissue lipid peroxidation in a rat model. ( Evliyaoğlu, Y; Kaya, B; Kayrin, L, 1997)
"This study indicates that intraoperative, intravenous pentoxifylline reduces hepatic injury after warm ischemia and reperfusion."	7.69	Effect of pentoxifylline on hepatic ischemia and reperfusion injury. ( Fabia, R; Goldstein, RM; Husberg, BS; Klintmalm, GB; Levy, MF; Travis, DL, 1997)
"The effect of pretreatment with pentoxifylline on normothermic liver ischemia was studied in rats."	7.69	[Liver damage due to normothermic ischemia and reperfusion in the rat. The effects of pentoxifylline pretreatment]. ( Castillo Olivares Ramos, JL; Martínez Onturbe, P; Navidad Novalvos, R; Ratia Giménez, T; Santamaría Solís, LV, 1995)
" Treatment with pentoxifylline 30 minutes after intestinal ischemia attenuated pulmonary macromolecular leakage (P < ."	7.69	Pentoxifylline attenuates pulmonary macromolecular leakage after intestinal ischemia-reperfusion. ( Carter, MB; Garrison, RN; Wead, WB; Wilson, MA, 1995)
"The administration of pentoxifylline at 25 mg/kg before reperfusion of ischemic skeletal muscle decreased significantly the extent of muscle necrosis and PAF levels in the venous effluents at all times of reperfusion (significantly at 10 minutes)."	7.69	Effect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury. ( Adams, JG; Dhar, A; Shukla, SD; Silver, D, 1995)
"Pentoxifylline (PTX) has been shown to suppress TNF alpha (released by activated macrophages, inhibiting subsequent superoxide anion release from neutrophil activation."	6.68	A randomized controlled trial of pentoxifylline for the prevention of delayed graft function in cadaveric kidney graft. ( Codaccioni, MX; Coppin, MC; Hazzan, M; Labalette, M; Lelièvre, G; Noël, C; Pruvot, FR, 1997)
"Pentoxifylline is a methylxanthine compound which was first filed in 1973 and registered in 1974 in the United States by Sanofi-Aventis Deustchland Gmbh for the treatment of intermittent claudication for chronic occlusive arterial disease."	6.50	Pentoxifylline in liver ischemia and reperfusion. ( Cejalvo, D; García, D; Genovés, P; Lloris-Carsi, JM; Martin, A; Toledo, AH; Toledo-Pereyra, LH; Zaragoza, C, 2014)
"Treatment with pentoxifylline significantly recovered the cerebral ischemia reperfusion‑induced neurological deficit score and cerebral infarct volume in rats."	5.48	Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway. ( Dong, J; Xie, W; Yuan, X, 2018)
"A major mode of cell death in spinal cord ischemia/reperfusion injury is necrosis while apoptosis is not dominant."	5.35	Functional protection of pentoxifylline against spinal cord ischemia/reperfusion injury in rabbits: necrosis and apoptosis effects. ( Bi, Q; Qiu, BS; Xia, B; Zhang, SJ; Zhao, C; Zhu, DJ, 2008)
"Unilateral testicular torsion and detorsion caused an increase in the MDA levels of both testes."	5.31	Pentoxifylline attenuates reperfusion injury in testicular torsion. ( Ataoglu, O; Bilgehan, A; Dindar, H; Savas, C; Yucesan, S, 2002)
"Pretreatment with allopurinol or pentoxifilline resulted in significantly lower hepatic enzyme elevation than that in controls in the rat liver ischaemia/reperfusion model."	5.31	Allopurinol plus pentoxifilline in hepatic ischaemia/reperfusion injury. ( Baykan, A; Erdem, L; Köksal, H; Tok, H; Yildirim, S, 2002)
"To clarify the effects of PTXF in reperfusion injury, we measured the resting transmembrane potential difference (Em) and evaluated postcapillary venule microcirculation using intravital microscopy in rat skeletal muscle during ischemia and reperfusion."	5.30	Pentoxifylline attenuates reperfusion injury in skeletal muscle after partial ischemia. ( Kishi, M; Matsuoka, T; Seiyama, A; Sugimoto, H; Takaoka, M; Tanaka, H; Yoshioka, T, 1998)
"This study was designed to investigate the effects of separate and combined administration of hypothermia and pentoxifylline to preserve the effects on the testicles in an experimental model of testicular torsion/ detorsion injuries in rats."	4.02	Effects of hypothermia and pentoxifylline on the adnexal torsion/detorsion injuries in a rat testis model. ( Abtahi-Eivary, SH; Brazvan, B; Elmimehr, R; Fani, M; Moghimian, M; Motamed-Sanaye, A, 2021)
"This study aimed to assess the clinical efficacy of pentoxifylline (PTX) and L-glutamine (L-Gln) treatment on ischemia and reperfusion (I/R) injury in the abomasal tissue, acute phase response (APR), oxidative stress (OS), cytokine response, hemostatic, and coagulation disorders in the 96-h period before and after surgery in displaced abomasum (DA) cases."	4.02	The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study. ( Arican, M; Çöl, R; Ider, M; Maden, M; Parlak, K; Tras, B; Yildiz, R, 2021)
" Since pentoxifylline (PTX) and steroids have distinct immunomodulatory properties, we aimed to evaluate for the first time their combined use in IRI-induced acute kidney injury (AKI) and chronic kidney disease (CKD) in rats."	3.88	Pentoxifylline and Methylprednisolone Additively Alleviate Kidney Failure and Prolong Survival of Rats after Renal Warm Ischemia-Reperfusion. ( Grzeszczak, W; Król, R; Więcek, A; Wystrychowski, A; Wystrychowski, G; Wystrychowski, W, 2018)
"Our findings demonstrate that pentoxifylline may be promising in preventing small bowel ischemia-reperfusion injury."	3.88	Role of pentoxifylline and iloprost in the prevention of ischemia-reperfusion injury in an experimental model of intestine ischemia-reperfusion in rats. ( Abakay, U; Çakmak, E; Genç, HÇ; Göksel, S; Korkmaz, Ö; Kurt, A; Şahin İnan, ZD; Saraç, B; Soylu, S, 2018)
"Ischemic preconditioning or pentoxifylline alone protect the intestinal mucosa from ischemia/reperfusion injury."	3.85	The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats. ( Fagundes, DJ; Monteiro, HP; Oliveira, GF; Oliveira, TRR; Simões, RS; Taha, MO; Tikazawa, EH, 2017)
"We studied the new anti-inflammatory effects of non-specific phosphodiesterase (PDE) inhibitor pentoxifylline (PTX) on ischaemia-reperfusion injury and postconditioning of the lower extremities."	3.85	Pentoxifylline attenuates the local and systemic inflammatory response after infrarenal abdominal aortic ischemia-reperfusion. ( Arató, E; Fazekas, G; Hardi, P; Jancsó, G; Nagy, T; Petrovics, L; Pintér, Ö; Sínay, L; Takács, I; Tóth, M, 2017)
"The combination of lidocaine, methylene blue and pentoxyphylline administered intraperitoneally at the studied dose, did not decreased histological lesion scores and biochemical markers levels in intestinal ischemia/reperfusion injury."	3.83	Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats. ( Cerri, S; Farca, AM; Gandini, M; Giusto, G; Iussich, S; Pregel, P; Tursi, M; Vercelli, C, 2016)
"To investigate the action of pentoxifylline (PTX) and prostaglandin E1 (PGE1) on ischemia and reperfusion of small intestine tissue in rats, using immunohistochemical analysis."	3.81	Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small intestine tissue in rats. An immunohistochemical study. ( Assis, PV; Aydos, RD; Brasileiro, JL; Marks, G; Ramalho, RT; Silva, IS; Takita, LC, 2015)
" Since Pentoxifylline, a methyl-xanthine derivative known for enhancement of vascular endothelial function, down-regulation of many inflammatory cytokines increased during preeclampsia, improvement of placental circulation, reduction of ischemia-reperfusion injury, enhancement of vasodilatation and endothelial function, ameliorating proteinuria, inhibition of platelet aggregation and decreasing risk of preterm labor, which are all amongst morbidities of preeclampsia, here it is hypothesized that Pentoxifylline prevents development of preeclampsia and/or decelerate progression of the disease."	3.81	Hypothesis: Pentoxifylline explores new horizons in treatment of preeclampsia. ( Azimi, A; Farhadi, P; Sagheb, MM; Ziaee, SM, 2015)
" Pentoxifylline (PTX) given before IRI attenuates inflammation and prevents ischemic acute kidney injury (iAKI)."	3.80	Nephroprotective effect of pentoxifylline in renal ischemia-reperfusion in rat depends on the timing of its administration. ( Grzeszczak, W; Obuchowicz, E; Więcek, A; Wystrychowski, A; Wystrychowski, G; Wystrychowski, W; Zukowska-Szczechowska, E, 2014)
"To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline."	3.80	Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats. ( Belon, AR; Carvalho, JG; Felice Neto, R; Marques, GM; Montero, EF; Rasslan, R; Rasslan, S; Utiyama, EM, 2014)
"Combining the hemodynamic and immune benefits of hypertonic saline with the anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline (HSPTX) as a hemorrhagic shock resuscitation strategy reduces lung injury when compared with the effects of Ringer's lactate (RL)."	3.76	A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock. ( Campos, Td; Coimbra, R; Costantini, TW; Deree, J; Martins, JO; Putnam, JG, 2010)
"Low-pressure pneumoperitoneum could attenuate ischemia/reperfusion injury induced by CO(2 )pneumoperitoneum in a rabbit model whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels."	3.75	Comparison of the effects of low intra-abdominal pressure and pentoxifylline on oxidative stress during CO2 pneumoperitoneum in rabbits. ( Kos, J; Krstonijević, Z; Nesek-Adam, V; Rasić, Z; Rumenjak, V; Vnuk, D, 2009)
" This study evaluated the role of pentoxifylline (PTX) and n-acetylcysteine (NAC) in the reduction of ischemia, reperfusion shock and associated intestinal injury."	3.74	Effects of pentoxifylline and n-acetylcysteine on injuries caused by ischemia and reperfusion of splanchnic organs in rats. ( Cerqueira, NF; Hussni, CA; Padovani, CR; Sequeira, JL; Yoshida, WB, 2008)
" We are of the opinion that in the early phase of skeletal muscle ischemia, iloprost and pentoxifylline medication may reduce ischemia-reperfusion injury."	3.74	Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model. ( Aksun, M; Bozok, S; Emrecan, B; Gürbüz, A; Ozcan, AV; Saçar, M; Tulukoğlu, E; Yağdi, S, 2008)
"These results indicate pentoxifylline diminishes leukocyte-endothelium interaction, and may have a therapeutic role in preventing ischemia reperfusion injury in microsurgical operations."	3.74	In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury. ( Dalcik, H; Iscen, D; Sen, C; Unal, C, 2007)
"Iloprost and pentoxyfillin reduced renal ischemia-reperfusion injury in rabbit model."	3.73	Effects of Iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model. ( Bozok, S; Emrecan, B; Gürbüz, A; Kestelli, M; Küpelioglu, A; Onem, G; Tulukoglu, E; Yagdi, S, 2006)
"Pentoxifylline, when administered to recipient animals, attenuates reperfusion injury to a degree similar to that seen with leukocyte-depleted reperfusion."	3.72	Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury. ( Clark, SC; Dark, JH; Flecknell, PA; Rao, JN, 2003)
"We examined the effect of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (ibudilast), which has been clinically used for bronchial asthma and cerebrovascular disorders, on cell viability induced in a model of reperfusion injury."	3.71	Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model. ( Baba, A; Enomoto, R; Lee, E; Matsuda, T; Mori, K; Takuma, K, 2001)
"To examine the effect of pentoxifylline (PTX) on cytokine levels, lipid peroxidation, and antioxidant enzymes in a rabbit model of spinal cord ischemia-reperfusion injury induced by aortic occlusion."	3.71	Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits. ( Cindaş, A; Delibaş, N; Savaş, C; Savaş, S; Sütçü, R, 2002)
"The beneficial effect of pentoxifylline (PTX) on ischaemic-reperfusion injury was assessed in a rat model of transient global cerebral ischaemia."	3.70	Pentoxifylline reduces injury of the brain in transient ischaemia. ( Coşkun, E; Ortaç, R; Sirin, BH; Sirin, H; Yilik, L, 1998)
"This study was designed to clarify the effects of pentoxifylline (PTX) and N-acetylcysteine (NAC) on hepatic reperfusion injury in rats."	3.70	Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury. ( Demir, S; Inal-Erden, M, 1998)
"Previous studies have suggested reductions in lung reperfusion injury with pentoxifylline, inositol polyanions, and the nitric oxide donor, SIN-1, but these agents have never been directly compared to ascertain which is superior."	3.70	Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1. ( Clark, SC; Dark, JH; Flecknell, PA; Roughan, J; Sudarshan, C, 1999)
"In an effort to determine whether treatment with lisofylline (LSF) ameliorates intestinal barrier dysfunction in rats subjected to mesenteric ischemia and reperfusion (I/R), regional mesenteric vessels were occluded for 60 min and then unclamped for 60 min more."	3.70	Lisofylline ameliorates intestinal mucosal barrier dysfunction caused by ischemia and ischemia/reperfusion. ( Delude, RL; Fink, MP; Menconi, MJ; Wattanasirichaigoon, S, 1999)
"We examined whether pentoxifylline (PTX) and coenzyme Q10 (Q) pretreatment affect ischemia-reperfusion damage in the rat liver."	3.70	Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury. ( Inal-Erden, M; Portakal, O, 1999)
" The aim of this study was to investigate: 1) whether brief exposure of rats to endotoxin before liver procurement aggravates the early phase of reperfusion injury of hepatic explants; and if so 2) whether Kupffer cell activation is a contributing factor to liver injury; and 3) whether heparin and pentoxifylline could minimize this effect."	3.70	Endotoxin-induced aggravation of preservation-reperfusion injury of rat liver and its modulation. ( Horecký, J; Jakubovský, J; Kukan, M; Lutterová, M; Smreková, R; Vajdová, K; van Rooijen, N; Wsólová, L, 2000)
"We sought to determine whether treatment with lisofylline (LSF) preserves intestinal barrier function in rats subjected to hemorrhagic shock and resuscitation (HS/R)."	3.70	Lisofylline ameliorates intestinal and hepatic injury induced by hemorrhage and resuscitation in rats. ( Fink, MP; Menconi, MJ; Wattanasirichaigoon, S, 2000)
"The effect of pretreatment with pentoxifylline on normothermic liver ischemia was studied in rats."	3.69	[Liver damage due to normothermic ischemia and reperfusion in the rat. The effects of pentoxifylline pretreatment]. ( Castillo Olivares Ramos, JL; Martínez Onturbe, P; Navidad Novalvos, R; Ratia Giménez, T; Santamaría Solís, LV, 1995)
"The administration of pentoxifylline at 25 mg/kg before reperfusion of ischemic skeletal muscle decreased significantly the extent of muscle necrosis and PAF levels in the venous effluents at all times of reperfusion (significantly at 10 minutes)."	3.69	Effect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury. ( Adams, JG; Dhar, A; Shukla, SD; Silver, D, 1995)
"Previously, pentoxifylline treatment of graft recipients was shown to protect against liver graft failure from storage/reperfusion injury after orthotopic rat liver transplantation."	3.69	Protection by pentoxifylline against normothermic liver ischemia/reperfusion in rats. ( Currin, RT; Lemasters, JJ; Peng, XX; Thurman, RG, 1995)
"This study examines the hypothesis that pentoxifylline protects splanchnic PGI2 synthesis during severe mesenteric ischemia/reperfusion injury."	3.69	Pentoxifylline protects splanchnic prostacyclin synthesis during mesenteric ischemia/reperfusion. ( Hernandez, R; Horton, JW; Myers, SI; Vaughan, WG; Walker, PB, 1994)
"This study indicates that intraoperative, intravenous pentoxifylline reduces hepatic injury after warm ischemia and reperfusion."	3.69	Effect of pentoxifylline on hepatic ischemia and reperfusion injury. ( Fabia, R; Goldstein, RM; Husberg, BS; Klintmalm, GB; Levy, MF; Travis, DL, 1997)
"Placebo and pentoxifylline were given to eight groups of rats prior to priapism being induced by a vacuum constrictive device for durations of 6 and 12 h, respectively."	3.69	Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissue lipid peroxidation in a rat model. ( Evliyaoğlu, Y; Kaya, B; Kayrin, L, 1997)
"We conclude that treatment with inhaled nitric oxide + pentoxifylline results in a synergistic protection from ischemia-reperfusion injury after non-heart-beating donor lung transplantation."	3.69	Inhaled nitric oxide and pentoxifylline in rat lung transplantation from non-heart-beating donors. The Paris-Sud University Lung Transplantation Group. ( Bacha, EA; Chapelier, AR; Dartevelle, PG; Détruit, H; Hervé, P; Mazmanian, GM; Murakami, S, 1997)
"The aim of this study was to determine the effects of pentoxifylline (Ptx) in reperfusion injury of the small bowel as a leukocyte stabilizer, free radical scavenger, and microcirculatory regulator."	3.69	Pentoxifylline inhibits overflow and reduces intestinal reperfusion injury. ( Aras, T; Ataoğlu, O; Bilgehan, A; Cakmak, M; Dindar, H; Ozgüner, F; Savaş, C; Türközkan, N; Yücesan, S, 1997)
" Treatment with pentoxifylline 30 minutes after intestinal ischemia attenuated pulmonary macromolecular leakage (P < ."	3.69	Pentoxifylline attenuates pulmonary macromolecular leakage after intestinal ischemia-reperfusion. ( Carter, MB; Garrison, RN; Wead, WB; Wilson, MA, 1995)
"Pentoxifylline (PTX) has been shown to suppress TNF alpha (released by activated macrophages, inhibiting subsequent superoxide anion release from neutrophil activation."	2.68	A randomized controlled trial of pentoxifylline for the prevention of delayed graft function in cadaveric kidney graft. ( Codaccioni, MX; Coppin, MC; Hazzan, M; Labalette, M; Lelièvre, G; Noël, C; Pruvot, FR, 1997)
"Many patients with intermittent claudication are encouraged to exercise."	2.67	Pharmacological reduction of the systemically damaging effects of local ischaemia. ( Gosling, P; Paterson, IS; Sanghera, K; Shearman, CP; Simms, MH; Smith, FC; Tsang, GM, 1994)
"Pentoxifylline is a methylxanthine compound which was first filed in 1973 and registered in 1974 in the United States by Sanofi-Aventis Deustchland Gmbh for the treatment of intermittent claudication for chronic occlusive arterial disease."	2.50	Pentoxifylline in liver ischemia and reperfusion. ( Cejalvo, D; García, D; Genovés, P; Lloris-Carsi, JM; Martin, A; Toledo, AH; Toledo-Pereyra, LH; Zaragoza, C, 2014)
"Treatment with pentoxifylline significantly recovered the cerebral ischemia reperfusion‑induced neurological deficit score and cerebral infarct volume in rats."	1.48	Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway. ( Dong, J; Xie, W; Yuan, X, 2018)
"Pretreatment with pentoxifylline markedly downregulated TNF-α at both the mRNA and protein levels, whereas infliximab pretreatment did not affect the expression of TNF-α induced by I/R."	1.39	Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury. ( Liu, HL; Tan, SW; Tao, J; Wu, B; Yang, Q; Zhan, YS; Zheng, FP, 2013)
"Pentoxifylline had a significant protective effect on severely ischemic bowel when administered during reperfusion at a dosage of 10 mg/kg."	1.39	Pentoxifylline protects the small intestine after severe ischemia and reperfusion. ( Cejalvo Lapeña, D; Lloris Carsi, JM; Toledo Pereyra, LH; Toledo, AH; Zaragoza Fernandez, C, 2013)
"PTX markedly attenuated lung injury as manifested by significant decreases (all P<0."	1.37	Pretreatment with pentoxifylline attenuates lung injury induced by intestinal ischemia/reperfusion in rats. ( Cavassani, SS; Ferez, D; Lopes, CA; Marqui, CE; Moraes, JB; Oliveira-Júnior, IS; Silva, DA; Silva, HC; Simões, RS; Taha, MO, 2011)
"Ischemia-reperfusion injury is believed to be a major cause of transferred skin flap failure."	1.36	Effects of pentoxyfilline and heparin on reperfusion injury island skin flaps in rats exposed to tobacco. ( Cherri, J; Freitas, FA; Marchesan, WG; Piccinato, CE, 2010)
"A major mode of cell death in spinal cord ischemia/reperfusion injury is necrosis while apoptosis is not dominant."	1.35	Functional protection of pentoxifylline against spinal cord ischemia/reperfusion injury in rabbits: necrosis and apoptosis effects. ( Bi, Q; Qiu, BS; Xia, B; Zhang, SJ; Zhao, C; Zhu, DJ, 2008)
"Pentoxifylline (PTX) has been reported to inhibit TNF-alpha production and prevent several types of acute renal failure."	1.32	Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits. ( Choi, TR; Jung, JS; Kim, JH; Kim, YK; Kwon, CH; Woo, JS, 2003)
"Pretreatment with allopurinol or pentoxifilline resulted in significantly lower hepatic enzyme elevation than that in controls in the rat liver ischaemia/reperfusion model."	1.31	Allopurinol plus pentoxifilline in hepatic ischaemia/reperfusion injury. ( Baykan, A; Erdem, L; Köksal, H; Tok, H; Yildirim, S, 2002)
"Pentoxifylline (PTX) has antiinflammatory effects and may limit endothelial dysfunction during ischemia/reperfusion."	1.31	Pentoxifylline reduces coronary leukocyte accumulation early in reperfusion after cold ischemia. ( Copeland, JG; Gale, SC; Gorman, GD; Hokama, JY; McDonagh, PF; Ritter, LS, 2001)
"Unilateral testicular torsion and detorsion caused an increase in the MDA levels of both testes."	1.31	Pentoxifylline attenuates reperfusion injury in testicular torsion. ( Ataoglu, O; Bilgehan, A; Dindar, H; Savas, C; Yucesan, S, 2002)
"Pentoxifylline (PTX) has been reported to suppress the activation of Kupffer cells and to decrease injury to the hepatic graft after rat liver transplantation."	1.30	Efficiency of pentoxifylline in donor pretreatment in rat liver transplantation. ( Asonuma, K; Egawa, H; Inomata, Y; Kiuchi, T; Nishizawa, H; Tanaka, K; Uemoto, S; Yamaoka, Y, 1997)
"Delayed paraplegia was observed in 6 rabbits (50%) in the PTX group and 7 rabbits (58%) in the CT group."	1.30	Evaluation of pentoxifylline in experimental spinal cord ischemia. ( Onat, U; Sağban, M; Sağýroğlu, E; Türköz, A; Türköz, R; Yörükoğlu, K, 1997)
"To clarify the effects of PTXF in reperfusion injury, we measured the resting transmembrane potential difference (Em) and evaluated postcapillary venule microcirculation using intravital microscopy in rat skeletal muscle during ischemia and reperfusion."	1.30	Pentoxifylline attenuates reperfusion injury in skeletal muscle after partial ischemia. ( Kishi, M; Matsuoka, T; Seiyama, A; Sugimoto, H; Takaoka, M; Tanaka, H; Yoshioka, T, 1998)
"Postischemic reperfusion injury is caused by microcirculatory disturbances, including both nutritive perfusion failure (no reflow) and leukocyte activation (reflow paradox)."	1.30	Pentoxifylline reduces venular leukocyte adherence ("reflow paradox") but not microvascular "no reflow" in hepatic ischemia/reperfusion. ( Menger, MD; Müller, JM; Vollmar, B, 1997)
"Pentoxifylline was also shown to suppress TNF release by lipopolysaccharide (LPS)-stimulated cultured rat Kupffer cells."	1.28	Protection by pentoxifylline against graft failure from storage injury after orthotopic rat liver transplantation with arterialization. ( Bachmann, S; Caldwell-Kenkel, JC; Currin, RT; Lemasters, JJ; Lichtman, SN; Steffen, R; Thurman, RG, 1992)

Research

Studies (107)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Number of Participants With Delayed Recovery of Liver Function

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.93)	18.7374
1990's	39 (36.45)	18.2507
2000's	34 (31.78)	29.6817
2010's	30 (28.04)	24.3611
2020's	3 (2.80)	2.80

Authors	Studies
Maden, M	1
Yildiz, R	1
Çöl, R	1
Arican, M	1
Ider, M	1
Parlak, K	1
Tras, B	1
El-Sadek, HM	1
Al-Shorbagy, MY	1
Awny, MM	1
Abdallah, DM	1
El-Abhar, HS	1
Elmimehr, R	1
Motamed-Sanaye, A	1
Brazvan, B	1
Abtahi-Eivary, SH	1
Moghimian, M	1
Fani, M	1
Oliveira, TRR	1
Oliveira, GF	1
Simões, RS	2
Tikazawa, EH	1
Monteiro, HP	1
Fagundes, DJ	1
Taha, MO	2
Dong, J	1
Yuan, X	1
Xie, W	1
Wystrychowski, G	2
Wystrychowski, W	3
Grzeszczak, W	2
Więcek, A	3
Król, R	1
Wystrychowski, A	3
Eğin, S	1
İlhan, M	1
Bademler, S	1
Gökçek, B	1
Hot, S	1
Ekmekçi, H	1
Ekmekçi, ÖB	1
Tanrıverdi, G	1
Dağıstanlı, FK	1
Kamalı, G	1
Kamalı, S	1
Güloğlu, R	1
Abakay, U	1
Soylu, S	1
Göksel, S	1
Saraç, B	1
Şahin İnan, ZD	1
Çakmak, E	1
Korkmaz, Ö	1
Kurt, A	1
Genç, HÇ	1
Le Campion, ER	1
Jukemura, J	1
Coelho, AM	2
Patzina, R	1
Carneiro D'Albuquerque, LA	1
Lloris Carsi, JM	1
Cejalvo Lapeña, D	1
Toledo, AH	2
Zaragoza Fernandez, C	1
Toledo Pereyra, LH	1
Ragavendran, JV	1
Laferrière, A	1
Khorashadi, M	1
Coderre, TJ	1
Yang, Q	1
Zheng, FP	1
Zhan, YS	1
Tao, J	1
Tan, SW	1
Liu, HL	1
Wu, B	1
Genovés, P	1
García, D	1
Cejalvo, D	1
Martin, A	1
Zaragoza, C	1
Toledo-Pereyra, LH	1
Lloris-Carsi, JM	1
Kalay, S	1
Islek, A	1
Ozturk, A	1
Kalay, Z	1
Elpek, O	1
Aldemir, H	1
Akçakuş, M	1
Oygur, N	1
Brasileiro, JL	2
Inoye, CM	1
Aydos, RD	2
Silva, IS	2
Falcão, GR	1
Marks, G	2
Pereira, DM	1
Zukowska-Szczechowska, E	1
Obuchowicz, E	2
Marques, GM	1
Rasslan, R	1
Belon, AR	1
Carvalho, JG	1
Felice Neto, R	1
Rasslan, S	1
Utiyama, EM	1
Montero, EF	1
Ramalho, RT	1
Takita, LC	1
Assis, PV	1
Rocha-Santos, V	1
Figueira, ER	1
Rocha-Filho, JA	1
Pinheiro, RS	1
Bacchella, T	1
Machado, MC	1
D'Albuquerque, LA	1
Azimi, A	1
Ziaee, SM	1
Farhadi, P	1
Sagheb, MM	1
Atochin, DN	1
Chernysheva, GA	1
Smolyakova, VI	1
Osipenko, AN	1
Logvinov, SV	1
Zhdankina, AA	1
Sysolyatin, SV	1
Kryukov, YA	1
Anfinogenova, Y	1
Plotnikova, TM	1
Plotnikov, MB	1
Gandini, M	1
Cerri, S	1
Pregel, P	1
Giusto, G	1
Vercelli, C	1
Iussich, S	1
Tursi, M	1
Farca, AM	1
Bektas, S	1
Karakaya, K	1
Can, M	1
Bahadir, B	1
Guven, B	1
Erdogan, N	1
Ozdamar, SO	1
Farag, MM	1
Khalifa, AA	1
Elhadidy, WF	1
Rashad, RM	1
Nagy, T	1
Hardi, P	1
Takács, I	1
Tóth, M	1
Petrovics, L	1
Jancsó, G	1
Sínay, L	1
Fazekas, G	1
Pintér, Ö	1
Arató, E	1
Emrecan, B	2
Tulukoğlu, E	2
Bozok, S	2
Aksun, M	1
Yağdi, S	2
Ozcan, AV	1
Saçar, M	1
Gürbüz, A	2
Cerqueira, NF	1
Hussni, CA	1
Yoshida, WB	1
Sequeira, JL	1
Padovani, CR	1
Zhu, DJ	1
Xia, B	1
Bi, Q	1
Zhang, SJ	1
Qiu, BS	1
Zhao, C	1
Hamidian Jahromi, A	1
Kessaris, N	1
Sharifian, M	1
Roozbeh, J	1
Oksuz, H	2
Bulbuloglu, E	2
Senoglu, N	2
Ciralik, H	1
Yuzbasioglu, MF	2
Kilinc, M	2
Dogan, Z	2
Goksu, M	1
Yildiz, H	2
Ozkan, OV	1
Atli, Y	2
Nesek-Adam, V	1
Vnuk, D	1
Rasić, Z	1
Rumenjak, V	1
Kos, J	1
Krstonijević, Z	1
Król, P	1
Cierpka, L	1
Groesdonk, HV	1
Heringlake, M	1
Heinze, H	1
Costantini, TW	1
Deree, J	1
Martins, JO	1
Putnam, JG	1
Campos, Td	1
Coimbra, R	1
Cámara-Lemarroy, CR	1
Guzmán-de la Garza, FJ	1
Alarcón-Galván, G	1
Cordero-Pérez, P	1
Muñoz-Espinosa, LE	1
Fernández-Garza, NE	1
Freitas, FA	1
Piccinato, CE	1
Cherri, J	1
Marchesan, WG	1
Ersoy, YE	1
Ayan, F	1
Himmetoglu, S	1
Marqui, CE	1
Silva, HC	1
Ferez, D	1
Cavassani, SS	1
Moraes, JB	1
Silva, DA	1
Lopes, CA	1
Oliveira-Júnior, IS	1
Coskuner, I	1
Deniz, C	1
Kantarçeken, B	1
Mahmoud, MF	1
El Shazly, SM	1
Barakat, W	1
Seifi, B	1
Kadkhodaee, M	1
Delavari, F	1
Mikaeili, S	1
Shams, S	1
Ostad, SN	1
Yildirim, S	1
Tok, H	1
Köksal, H	1
Erdem, L	1
Baykan, A	1
Iwamoto, H	1
Kozaki, K	2
Nakamura, N	1
Hama, K	1
Narumi, K	1
Matsuno, N	2
Kuzuoka, K	1
Taira, S	1
Kihara, Y	1
Uchiyama, M	1
Takeuchi, H	1
Nagao, T	1
Rao, JN	2
Clark, SC	5
Ali, S	1
Kirby, J	1
Flecknell, PA	4
Dark, JH	5
Tireli, GA	1
Salman, T	1
Ozbey, H	1
Abbasoglu, L	1
Toker, G	1
Celik, A	1
Selzner, N	1
Rudiger, H	1
Graf, R	2
Clavien, PA	2
Bachmann, S	1
Caldwell-Kenkel, JC	1
Currin, RT	2
Lichtman, SN	1
Steffen, R	1
Thurman, RG	2
Lemasters, JJ	2
Kim, YK	2
Choi, TR	1
Kwon, CH	1
Kim, JH	1
Woo, JS	2
Jung, JS	2
Cavriani, G	2
Domingos, HV	2
Soares, AL	1
Trezena, AG	1
Ligeiro-Oliveira, AP	1
Oliveira-Filho, RM	2
Sudo-Hayashi, LS	2
Tavares de Lima, W	1
Uguralp, S	1
Bay Karabulut, A	1
Mizrak, B	1
Tian, Y	1
Jochum, W	1
Georgiev, P	1
Moritz, W	1
Kestelli, M	1
Onem, G	1
Küpelioglu, A	1
Vargaftig, BB	1
de Lima, WT	1
Unal, C	1
Sen, C	1
Iscen, D	1
Dalcik, H	1
Sage, E	1
Mercier, O	1
Van den Eyden, F	1
de Perrot, M	1
Barlier-Mur, AM	1
Dartevelle, P	2
Eddahibi, S	1
Herve, P	6
Fadel, E	1
Kaptanoglu, L	1
Kapan, M	1
Kapan, S	1
Goksoy, E	1
Oktar, H	1
Carter, MB	1
Wilson, MA	1
Wead, WB	1
Garrison, RN	1
Ratia Giménez, T	1
Navidad Novalvos, R	1
Martínez Onturbe, P	1
Santamaría Solís, LV	1
Castillo Olivares Ramos, JL	1
Normandin, L	1
Brink, C	1
Chapelier, AR	2
Dartevelle, PG	2
Mazmanian, GM	2
Adams, JG	1
Dhar, A	1
Shukla, SD	1
Silver, D	1
Peng, XX	1
Myers, SI	2
Horton, JW	2
Hernandez, R	1
Walker, PB	1
Vaughan, WG	1
Okabayashi, K	1
Aoe, M	1
DeMeester, SR	1
Cooper, JD	1
Patterson, GA	1
Reignier, J	2
Mazmanian, M	2
Detruit, H	3
Chapelier, A	2
Weiss, M	1
Libert, JM	1
Hanazawa, S	1
Prewitt, RL	1
Terzis, JK	1
Tsang, GM	1
Sanghera, K	1
Gosling, P	1
Smith, FC	1
Paterson, IS	1
Simms, MH	1
Shearman, CP	1
White, DJ	1
Kozaki, M	1
Parquin, F	1
Cerrina, J	1
Le Roy Ladurie, F	1
Wada, K	1
Kamisaki, Y	1
Kitano, M	1
Kishimoto, Y	1
Nakamoto, K	1
Itoh, T	1
Coe, DA	1
Freischlag, JA	1
Johnson, D	1
Mudaliar, JH	1
Kosciesza, SA	1
Traul, DK	1
Chiang, PC	1
Cambria, RA	1
Seabrook, GR	1
Towne, JB	1
Schmid, RA	1
Yamashita, M	1
Fabia, R	1
Travis, DL	1
Levy, MF	1
Husberg, BS	1
Goldstein, RM	1
Klintmalm, GB	1
Evliyaoğlu, Y	1
Kayrin, L	1
Kaya, B	1
Murakami, S	1
Bacha, EA	1
Noël, C	1
Hazzan, M	1
Coppin, MC	1
Codaccioni, MX	1
Pruvot, FR	1
Labalette, M	1
Lelièvre, G	1
Savaş, C	3
Aras, T	1
Cakmak, M	1
Bilgehan, A	2
Ataoğlu, O	2
Türközkan, N	1
Ozgüner, F	1
Yücesan, S	2
Dindar, H	2
Rothenbach, P	1
Turnage, RH	1
Iglesias, J	1
Riva, A	1
Bartula, L	1
Müller, JM	1
Vollmar, B	1
Menger, MD	1
Nishizawa, H	1
Egawa, H	1
Inomata, Y	1
Uemoto, S	1
Asonuma, K	1
Kiuchi, T	1
Yamaoka, Y	1
Tanaka, K	1
Türköz, A	1
Türköz, R	1
Yörükoğlu, K	1
Onat, U	1
Sağýroğlu, E	1
Sağban, M	1
Kleinschmidt, S	1
Bauer, M	1
Grundmann, U	1
Schneider, A	1
Wagner, B	1
Graeter, T	1
Hotchkiss, RS	1
Karl, IE	1
Kishi, M	1
Tanaka, H	1
Seiyama, A	1
Takaoka, M	1
Matsuoka, T	1
Yoshioka, T	1
Sugimoto, H	1
Sudarshan, C	2
Khanna, R	1
Roughan, J	2
Sirin, BH	1
Yilik, L	1
Coşkun, E	1
Ortaç, R	1
Sirin, H	1
Demir, S	1
Inal-Erden, M	2
Wattanasirichaigoon, S	2
Menconi, MJ	2
Delude, RL	1
Fink, MP	2
Hammerman, C	1
Goldschmidt, D	1
Caplan, MS	1
Kaplan, M	1
Schimmel, MS	1
Eidelman, AI	1
Branski, D	1
Hochman, A	1
Fujimura, M	1
Gasche, Y	1
Morita-Fujimura, Y	1
Massengale, J	1
Kawase, M	1
Chan, PH	1
Portakal, O	1
Vajdová, K	1
Smreková, R	1
Kukan, M	1
Jakubovský, J	1
van Rooijen, N	1
Horecký, J	1
Lutterová, M	1
Wsólová, L	1
Klinzing, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effectiveness of N-acetylcysteine on Preservation Solution During Liver Transplantation[NCT01866644]	Phase 3	214 participants (Actual)	Interventional	2011-09-30	Completed
The Effect of Remote Ischemic Preconditioning on the Postoperative Liver Function in Living Donor Hepatectomy: a Randomized Clinical Trial[NCT03386435]		160 participants (Actual)	Interventional	2016-08-22	Completed
A Multi-Center, Open-Label Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS)[NCT02714036]	Phase 1/Phase 2	35 participants (Actual)	Interventional	2016-05-06	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The incidence of delayed recovery of hepatic function (DRHF) were used as surrogate parameters indicating the possible benefits of RIPC. DRHF was defined based on a proposal by the International Study Group of Liver Surgery, as follows: an impaired ability of the liver to maintain its synthetic, excretory, and detoxifying functions, which are characterized by an increased PT INR and concomitant hyperbilirubinemia (considering the normal limits of the local laboratory) on or after postoperative day 5. The normal upper limits of PT and bilirubin in our institutional laboratory were 1.30 INR and 1.2 mg/dL, respectively. If either the PT INR or serum bilirubin concentration was preoperatively elevated, DRHF was defined by an increasing PT INR and increasing serum bilirubin concentration on or after postoperative day 5 (compared with the values of the previous day). (NCT03386435)
Timeframe: postoperative 7 days

Postopera The Maximal Aspartate Aminotransferase Level Within 7 Postoperative Days

Intervention	Participants (Count of Participants)
RIPC	5
Control	0

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal aspartate aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy. (NCT03386435)
Timeframe: within 7 days after operation

Postoperative Liver Regeneration

Intervention	IU/L (Mean)
RIPC	145
Control	152

The postoperative liver regeneration index (LRI) at postoperative 1 month ) was used as surrogate parameters indicating the possible benefits of RIPC. The LRI was defined as [(VLR - VFLR)/VFLR)] × 100, where VLR is the volume of the liver remnant and VFLR is the volume of the future liver remnant. Liver volume was calculated by CT volumetry using 3-mm-thick dynamic CT images. The graft weight was subtracted from the total liver volume to define the future liver remnant. (NCT03386435)
Timeframe: 1 month

The Maximal Alanine Aminotransferase Level Within 7 Postoperative Days

Intervention	percentage of liver volume (Mean)
RIPC	83.3
Control	94.9

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal alanine aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy (NCT03386435)
Timeframe: within 7 days after operation

Article	Year
Pentoxifylline in liver ischemia and reperfusion. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2014, Volume: 27, Issue:2 Topics: Animals; Apoptosis; Humans; Ischemia; Liver; Liver Diseases; Liver Transplantation; Pentoxifylline;	2014
[Anti-inflammatory effects of pentoxifylline: importance in cardiac surgery]. Der Anaesthesist, 2009, Volume: 58, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Humans; Pentoxifylline; Phosph	2009
Protective strategies against ischemic injury of the liver. Gastroenterology, 2003, Volume: 125, Issue:3 Topics: Animals; Antioxidants; Genetic Therapy; Humans; Ischemia; Ischemic Preconditioning; Liver; Organ Pre	2003
Protective strategies against ischemic injury of the liver. Gastroenterology, 2003, Volume: 125, Issue:3 Topics: Animals; Antioxidants; Genetic Therapy; Humans; Ischemia; Ischemic Preconditioning; Liver; Organ Pre	2003
Protective strategies against ischemic injury of the liver. Gastroenterology, 2003, Volume: 125, Issue:3 Topics: Animals; Antioxidants; Genetic Therapy; Humans; Ischemia; Ischemic Preconditioning; Liver; Organ Pre	2003
Protective strategies against ischemic injury of the liver. Gastroenterology, 2003, Volume: 125, Issue:3 Topics: Animals; Antioxidants; Genetic Therapy; Humans; Ischemia; Ischemic Preconditioning; Liver; Organ Pre	2003

Article	Year
Pharmacological reduction of the systemically damaging effects of local ischaemia. European journal of vascular surgery, 1994, Volume: 8, Issue:2 Topics: Aged; Albuminuria; Capillary Permeability; Double-Blind Method; Exercise Test; Exercise Tolerance; F	1994
A randomized controlled trial of pentoxifylline for the prevention of delayed graft function in cadaveric kidney graft. Clinical transplantation, 1997, Volume: 11, Issue:3 Topics: Adult; Cadaver; Cyclosporine; Double-Blind Method; Endothelium, Vascular; Female; Humans; Immunosupp	1997
[Effect of gamma-hydroxybutyric acid and pentoxifylline on kidney function parameters in coronary surgery interventions]. Anaesthesiologie und Reanimation, 1997, Volume: 22, Issue:4 Topics: Aged; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Humans; Infusions, Intravenous; Kidney	1997

Article	Year
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study. Polish journal of veterinary sciences, 2021, Volume: 24, Issue:4 Topics: Abomasum; Animals; Cattle; Cattle Diseases; Female; Glutamine; Ischemia; Longitudinal Studies; Pento	2021
Pentoxifylline treatment alleviates kidney ischemia/reperfusion injury: Novel involvement of galectin-3 and ASK-1/JNK & ERK1/2/NF-κB/HMGB-1 trajectories. Journal of pharmacological sciences, 2021, Volume: 146, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Galectin 3; HMGB1 Protein;	2021
Effects of hypothermia and pentoxifylline on the adnexal torsion/detorsion injuries in a rat testis model. Andrologia, 2021, Volume: 53, Issue:8 Topics: Animals; Female; Humans; Hypothermia; Male; Malondialdehyde; Ovarian Torsion; Oxidative Stress; Pent	2021
The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats. Acta cirurgica brasileira, 2017, Volume: 32, Issue:7 Topics: Animals; Disease Models, Animal; Intestines; Ischemic Preconditioning; Male; Pentoxifylline; Rats; R	2017
Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway. Molecular medicine reports, 2018, Volume: 17, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Caspase 3; Cyclooxygenase 2; Cytokines; Disease M	2018
Pentoxifylline and Methylprednisolone Additively Alleviate Kidney Failure and Prolong Survival of Rats after Renal Warm Ischemia-Reperfusion. International journal of molecular sciences, 2018, Jan-11, Volume: 19, Issue:1 Topics: Acute Kidney Injury; Animals; Glucocorticoids; Kidney; Male; Methylprednisolone; Pentoxifylline; Rat	2018
Protective effects of pentoxifylline in small intestine after ischemia-reperfusion. The Journal of international medical research, 2018, Volume: 46, Issue:10 Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Hematologic Agents; Infusions, Parenteral; I	2018
Role of pentoxifylline and iloprost in the prevention of ischemia-reperfusion injury in an experimental model of intestine ischemia-reperfusion in rats. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2018, Volume: 24, Issue:5 Topics: Animals; Disease Models, Animal; Free Radical Scavengers; Ileal Diseases; Ileum; Male; Pentoxifyllin	2018
Effects of intravenous administration of pentoxifylline in pancreatic ischaemia-reperfusion injury. HPB : the official journal of the International Hepato Pancreato Biliary Association, 2013, Volume: 15, Issue:8 Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Inflammation Mediators; Injec	2013
Pentoxifylline protects the small intestine after severe ischemia and reperfusion. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2013, Volume: 11, Issue:3 Topics: Animals; Biomarkers; Blood Flow Velocity; Cytoprotection; Disease Models, Animal; Inflammation Media	2013
Pentoxifylline reduces chronic post-ischaemia pain by alleviating microvascular dysfunction. European journal of pain (London, England), 2014, Volume: 18, Issue:3 Topics: Animals; Disease Models, Animal; Ischemia; Male; Microvessels; Pain; Pain Measurement; Pentoxifyllin	2014
Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury. World journal of gastroenterology, 2013, Aug-14, Volume: 19, Issue:30 Topics: Animals; Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspase 9; Disease Models, Animal; Enzyme Act	2013
Pentoxifylline therapy attenuates intestinal injury in rat pups with hypoxic ischemic encephalopathy. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:14 Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Free Radical Scavengers; Hypoxia; Hypoxia	2014
Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1. Acta cirurgica brasileira, 2013, Volume: 28, Issue:11 Topics: Alprostadil; Animals; Disease Models, Animal; Intestinal Mucosa; Intestine, Small; Ischemia; Male; P	2013
Nephroprotective effect of pentoxifylline in renal ischemia-reperfusion in rat depends on the timing of its administration. Transplantation proceedings, 2014, Volume: 46, Issue:8 Topics: Acute Kidney Injury; Animals; Constriction; Free Radical Scavengers; Inflammation; Kidney; Kidney Tr	2014
Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats. Acta cirurgica brasileira, 2014, Volume: 29, Issue:11 Topics: Animals; Apoptosis; Caspase 3; Cyclooxygenase 2; Immunohistochemistry; Intestines; Ischemia; Lactic	2014
Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small intestine tissue in rats. An immunohistochemical study. Acta cirurgica brasileira, 2015, Volume: 30, Issue:2 Topics: Alprostadil; Animals; Apoptosis; Disease Models, Animal; Immunohistochemistry; Intestinal Mucosa; In	2015
Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress. Hepatobiliary & pancreatic diseases international : HBPD INT, 2015, Volume: 14, Issue:2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Capillary Permeability; Disease Models,	2015
Hypothesis: Pentoxifylline explores new horizons in treatment of preeclampsia. Medical hypotheses, 2015, Volume: 85, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Blood Coagulation; Cytokines; Disease Progression; Endothelium, Va	2015
Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Jun-15, Volume: 23, Issue:7 Topics: Animals; Antioxidants; Behavior, Animal; Brain Ischemia; CA1 Region, Hippocampal; Cerebral Infarctio	2016
Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats. Acta cirurgica brasileira, 2016, Volume: 31, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Drug Combinations; Drug Synergism; Inflammation; Infusions, Paren	2016
The effects of tadalafil and pentoxifylline on apoptosis and nitric oxide synthase in liver ischemia/reperfusion injury. The Kaohsiung journal of medical sciences, 2016, Volume: 32, Issue:7 Topics: Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Female; Immunohistochemistry; Liver; Nit	2016
Hepatorenal protection in renal ischemia/reperfusion by celecoxib and pentoxifylline. The Journal of surgical research, 2016, Volume: 204, Issue:1 Topics: Animals; Biomarkers; Celecoxib; Drug Administration Schedule; Drug Therapy, Combination; Kidney; Kid	2016
Pentoxifylline attenuates the local and systemic inflammatory response after infrarenal abdominal aortic ischemia-reperfusion. Clinical hemorheology and microcirculation, 2017, Volume: 65, Issue:3 Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Ischemia; Male; Pentoxifylline; Rats; Rats, W	2017
Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2008, Volume: 14, Issue:3 Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Edema; Female; Humans; Iloprost; Male; M	2008
Effects of pentoxifylline and n-acetylcysteine on injuries caused by ischemia and reperfusion of splanchnic organs in rats. International angiology : a journal of the International Union of Angiology, 2008, Volume: 27, Issue:6 Topics: Acetylcysteine; Animals; Disease Models, Animal; Free Radical Scavengers; Hemodynamics; Intestinal M	2008
Functional protection of pentoxifylline against spinal cord ischemia/reperfusion injury in rabbits: necrosis and apoptosis effects. Chinese medical journal, 2008, Dec-05, Volume: 121, Issue:23 Topics: Animals; Apoptosis; Caspase 3; Immunohistochemistry; In Situ Nick-End Labeling; Microscopy, Electron	2008
Protective effect of pentoxifylline in the kidney perfusion fluid on the transplanted kidney. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2009, Volume: 20, Issue:2 Topics: Animals; Humans; Kidney Failure, Chronic; Kidney Transplantation; Organ Preservation; Pentoxifylline	2009
Re-protective effects of pre- and post-laparoscopy conditioning, zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the kidney. Renal failure, 2009, Volume: 31, Issue:4 Topics: Acetylcysteine; Animals; Disease Models, Animal; Kidney; Laparoscopy; Male; Pentoxifylline; Pneumope	2009
Comparison of the effects of low intra-abdominal pressure and pentoxifylline on oxidative stress during CO2 pneumoperitoneum in rabbits. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2009, Volume: 43, Issue:4 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Dioxide; Female; Free Radical Sca	2009
Pentoxifylline augments fasting-induced nephroprotection in acute ischemic kidney injury in rats. Transplantation proceedings, 2009, Volume: 41, Issue:8 Topics: Acute Kidney Injury; Animal Feed; Animals; Creatinine; Fasting; Ischemia; Kidney Tubules; Male; Neph	2009
A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock. Clinics (Sao Paulo, Brazil), 2010, Volume: 65, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inflammation Mediators; Lung; Male; NF-ka	2010
Effects of thalidomide and pentoxyphylline over local and remote organ injury after intestinal ischemia/reperfusion. Transplantation proceedings, 2010, Volume: 42, Issue:5 Topics: Animals; Aspartate Aminotransferases; Enzyme-Linked Immunosorbent Assay; Intestinal Mucosa; Intestin	2010
Effects of pentoxyfilline and heparin on reperfusion injury island skin flaps in rats exposed to tobacco. The Journal of surgical research, 2010, Volume: 164, Issue:1 Topics: Animals; Anticoagulants; Dermatologic Surgical Procedures; Drug Therapy, Combination; Free Radical S	2010
Trace element levels in ischemia-reperfusion injury after left colonic anastomosis in rats and effects of papaverine and pentoxiphylline on vascular endothelial growth factor in anastomosis healing. Acta gastro-enterologica Belgica, 2011, Volume: 74, Issue:1 Topics: Animals; Colon; Female; Papaverine; Pentoxifylline; Rats; Rats, Wistar; Reperfusion Injury; Trace El	2011
Pretreatment with pentoxifylline attenuates lung injury induced by intestinal ischemia/reperfusion in rats. Acta cirurgica brasileira, 2011, Volume: 26, Issue:6 Topics: Animals; Free Radical Scavengers; Intestines; Lung Injury; Male; Pentoxifylline; Rats; Rats, Wistar;	2011
Protective effects of zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the small intestine. Journal of laparoendoscopic & advanced surgical techniques. Part A, 2011, Volume: 21, Issue:10 Topics: Acetylcysteine; Animals; Disease Models, Animal; Free Radical Scavengers; Intestine, Small; Laparosc	2011
Inhibition of TNF-α protects against hepatic ischemia-reperfusion injury in rats via NF-κB dependent pathway. Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:5 Topics: Alanine Transaminase; Animals; Antibodies, Monoclonal; Aspartate Aminotransferases; Gene Expression;	2012
Pretreatment with pentoxifylline and N-acetylcysteine in liver ischemia reperfusion-induced renal injury. Renal failure, 2012, Volume: 34, Issue:5 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Disease Models, Animal; Dose-Response Relationship, Dr	2012
Allopurinol plus pentoxifilline in hepatic ischaemia/reperfusion injury. Asian journal of surgery, 2002, Volume: 25, Issue:2 Topics: Allopurinol; Animals; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Ischemia	2002
Beneficial effects of pentoxifylline and propentofylline on the warm ischemic injury of rat livers. Transplantation proceedings, 2002, Volume: 34, Issue:7 Topics: Animals; Hematologic Agents; Liver; Liver Circulation; Liver Function Tests; Models, Animal; Pentoxi	2002
Improvements in lung compliance after pulmonary transplantation: correlation with interleukin 8 expression. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2003, Volume: 23, Issue:4 Topics: Animals; Area Under Curve; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Female; Interleu	2003
The effect of pentoxifylline on intestinal anastomotic healing after ischemia. Pediatric surgery international, 2003, Volume: 19, Issue:1-2 Topics: Anastomosis, Surgical; Animals; Hematologic Agents; Hydroxyproline; Intestine, Small; Male; Mesenter	2003
Protection by pentoxifylline against graft failure from storage injury after orthotopic rat liver transplantation with arterialization. Transplant international : official journal of the European Society for Organ Transplantation, 1992, Volume: 5 Suppl 1 Topics: Animals; Antioxidants; Free Radical Scavengers; Graft Rejection; Graft Survival; Liver Transplantati	1992
Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits. Renal failure, 2003, Volume: 25, Issue:6 Topics: Acute Kidney Injury; Animals; Apoptosis; Base Sequence; Cisplatin; Disease Models, Animal; Female; G	2003
Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury. The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:6 Topics: Animals; Female; Leukapheresis; Leukocyte Elastase; Lung Transplantation; Malondialdehyde; Pentoxify	2003
Lymphatic system as a path underlying the spread of lung and gut injury after intestinal ischemia/reperfusion in rats. Shock (Augusta, Ga.), 2005, Volume: 23, Issue:4 Topics: Animals; Inflammation; Intestinal Mucosa; Intestines; L-Lactate Dehydrogenase; Lung; Lymph; Lymphati	2005
Effects of pentoxifylline and vitamin E on the bilateral ovary after experimental ovarian ischemia. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2005, Volume: 15, Issue:2 Topics: Animals; Antioxidants; Female; Ischemia; Models, Animal; Ovarian Diseases; Ovary; Pentoxifylline; Ra	2005
Kupffer cell-dependent TNF-alpha signaling mediates injury in the arterialized small-for-size liver transplantation in the mouse. Proceedings of the National Academy of Sciences of the United States of America, 2006, Mar-21, Volume: 103, Issue:12 Topics: Animals; Arteries; Gadolinium; Graft Survival; Interleukin-10; Interleukin-6; Kupffer Cells; Liver;	2006
Effects of Iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model. European journal of medical research, 2006, Jul-31, Volume: 11, Issue:7 Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Iloprost; Kidney; Kidney Cortex;	2006
Lymphatic thoracic duct ligation modulates the serum levels of IL-1beta and IL-10 after intestinal ischemia/reperfusion in rats with the involvement of tumor necrosis factor alpha and nitric oxide. Shock (Augusta, Ga.), 2007, Volume: 27, Issue:2 Topics: Animals; Enzyme Inhibitors; Interleukin-10; Interleukin-1beta; Intestines; Ligation; Male; NG-Nitroa	2007
In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury. The Journal of surgical research, 2007, Volume: 138, Issue:2 Topics: Animals; Catheterization; Cell Communication; Disease Models, Animal; Endothelial Cells; Leukocyte R	2007
Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery. Respiratory research, 2008, Feb-12, Volume: 9 Topics: Animals; Apoptosis; Chronic Disease; Disease Models, Animal; Endarterectomy; Endothelial Cells; Free	2008
Effects of nimodipine and pentoxyfylline in prevention of hepatic ischemic damage in rats at normal and hypothermic conditions. European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium Channel Blockers; Hypothermia; L	2008
Pentoxifylline attenuates pulmonary macromolecular leakage after intestinal ischemia-reperfusion. Archives of surgery (Chicago, Ill. : 1960), 1995, Volume: 130, Issue:12 Topics: Animals; Blood-Air Barrier; Cardiac Output; Disease Models, Animal; Hemodynamics; Intestines; Ischem	1995
[Liver damage due to normothermic ischemia and reperfusion in the rat. The effects of pentoxifylline pretreatment]. Revista espanola de enfermedades digestivas, 1995, Volume: 87, Issue:7 Topics: Animals; Drug Evaluation, Preclinical; Ischemia; Liver; Liver Diseases; Male; Necrosis; Pentoxifylli	1995
L-arginine and pentoxifylline attenuate endothelial dysfunction after lung reperfusion injury in the rabbit. The Paris-Sud University Lung Transplant Group. The Annals of thoracic surgery, 1995, Volume: 60, Issue:3 Topics: Acetylcholine; Animals; Arginine; Blood; Cardiopulmonary Bypass; Cold Temperature; Endothelium, Vasc	1995
Effect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury. Journal of vascular surgery, 1995, Volume: 21, Issue:5 Topics: Animals; Blood Pressure; Dogs; Female; Heart Rate; Infusions, Intravenous; Models, Cardiovascular; M	1995
Protection by pentoxifylline against normothermic liver ischemia/reperfusion in rats. Transplantation, 1995, Jun-15, Volume: 59, Issue:11 Topics: Animals; Liver; Liver Transplantation; Male; Pentoxifylline; Rats; Rats, Sprague-Dawley; Reperfusion	1995
Pentoxifylline protects splanchnic prostacyclin synthesis during mesenteric ischemia/reperfusion. Prostaglandins, 1994, Volume: 47, Issue:2 Topics: Allopurinol; Animals; Drug Carriers; Epoprostenol; Hemodynamics; Male; Mesenteric Arteries; Pentoxif	1994
Pentoxifylline reduces lung allograft reperfusion injury. The Annals of thoracic surgery, 1994, Volume: 58, Issue:1 Topics: Animals; Dogs; Hypertonic Solutions; Lung; Lung Transplantation; Organ Preservation; Pentoxifylline;	1994
Reduction of ischemia-reperfusion injury by pentoxifylline in the isolated rat lung. Paris-Sud University Lung Transplantation Group. American journal of respiratory and critical care medicine, 1994, Volume: 150, Issue:2 Topics: Animals; Capillary Resistance; In Vitro Techniques; Leukocyte Count; Lung; Male; Neutrophils; Pentox	1994
The effect of pentoxifylline on ischemia and reperfusion injury in the rat cremaster muscle. Journal of reconstructive microsurgery, 1994, Volume: 10, Issue:1 Topics: Animals; Arteries; Blood Flow Velocity; Cell Adhesion; Cell Aggregation; Ischemia; Leukocytes; Male;	1994
Free radical scavengers prevent intestinal ischemia-reperfusion-mediated cardiac dysfunction. The Journal of surgical research, 1993, Volume: 55, Issue:3 Topics: Animals; Catalase; Constriction; Free Radical Scavengers; Heart Diseases; Heart Rate; Intestines; Is	1993
Beneficial effects of pentoxifylline and propentofylline on preservation-reperfusion injury in rat liver transplantation. Transplantation proceedings, 1996, Volume: 28, Issue:1 Topics: Adenosine; Alanine Transaminase; Allopurinol; Animals; Anti-Ulcer Agents; Biomarkers; Glutathione; I	1996
Pentoxifylline and lung ischemia-reperfusion injury: application to lung transplantation. Université Paris-Sud Lung Transplant Group. Journal of cardiovascular pharmacology, 1995, Volume: 25 Suppl 2 Topics: Animals; Endothelium, Vascular; Ischemia; Lung Transplantation; Neutrophils; Pentoxifylline; Pulmona	1995
A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach. Life sciences, 1996, Volume: 59, Issue:19 Topics: Animals; Anti-Ulcer Agents; Antibodies, Monoclonal; CD18 Antigens; Disease Models, Animal; Gastric A	1996
Pentoxifylline prevents endothelial damage due to ischemia and reperfusion injury. The Journal of surgical research, 1997, Volume: 67, Issue:1 Topics: Acetylcholine; Animals; Endothelium, Vascular; Femoral Artery; In Vitro Techniques; Ischemia; Norepi	1997
Effect of pentoxifylline in a canine and porcine model of pulmonary allograft reperfusion injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1997, Volume: 16, Issue:3 Topics: Animals; Dogs; Infusions, Intravenous; Lung Transplantation; Pentoxifylline; Pulmonary Gas Exchange;	1997
Effect of pentoxifylline on hepatic ischemia and reperfusion injury. Surgery, 1997, Volume: 121, Issue:5 Topics: Administration, Oral; Animals; Injections, Intravenous; Ischemia; Liver; Liver Circulation; Pentoxif	1997
Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissue lipid peroxidation in a rat model. Urological research, 1997, Volume: 25, Issue:2 Topics: Animals; Disease Models, Animal; Lipid Peroxidation; Male; Malondialdehyde; Penile Erection; Penis;	1997
Inhaled nitric oxide and pentoxifylline in rat lung transplantation from non-heart-beating donors. The Paris-Sud University Lung Transplantation Group. The Journal of thoracic and cardiovascular surgery, 1997, Volume: 113, Issue:5 Topics: Animals; Drug Synergism; Hemodynamics; Lung; Lung Transplantation; Male; Neutrophils; Nitric Oxide;	1997
Pentoxifylline inhibits overflow and reduces intestinal reperfusion injury. Journal of pediatric surgery, 1997, Volume: 32, Issue:6 Topics: Animals; Disease Models, Animal; Intestinal Mucosa; Intestine, Small; Male; Malondialdehyde; Pentoxi	1997
Downstream effects of splanchnic ischemia-reperfusion injury on renal function and eicosanoid release. Journal of applied physiology (Bethesda, Md. : 1985), 1997, Volume: 83, Issue:2 Topics: Allopurinol; Animals; Blood Pressure; Eicosanoids; Imidazoles; In Vitro Techniques; Inulin; Ischemia	1997
Pentoxifylline reduces venular leukocyte adherence ("reflow paradox") but not microvascular "no reflow" in hepatic ischemia/reperfusion. The Journal of surgical research, 1997, Jul-15, Volume: 71, Issue:1 Topics: Animals; Cell Adhesion; Leukocytes; Liver; Microcirculation; Pentoxifylline; Phosphodiesterase Inhib	1997
Efficiency of pentoxifylline in donor pretreatment in rat liver transplantation. The Journal of surgical research, 1997, Volume: 72, Issue:2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Enzyme	1997
Evaluation of pentoxifylline in experimental spinal cord ischemia. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1997, Volume: 12, Issue:4 Topics: Animals; Neutrophil Activation; Paraplegia; Pentoxifylline; Rabbits; Reperfusion Injury; Spinal Cord	1997
Pentoxifylline and modulation of the inflammatory response. Critical care medicine, 1998, Volume: 26, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Calcium; Cytokines; Liver; Pentoxifylline; Rats; Reperfusion Inju	1998
Pentoxifylline attenuates reperfusion injury in skeletal muscle after partial ischemia. The American journal of physiology, 1998, Volume: 274, Issue:5 Topics: Animals; Ischemia; Leukocytes; Male; Membrane Potentials; Microcirculation; Muscle, Skeletal; Pentox	1998
Controlled reperfusion and pentoxifylline modulate reperfusion injury after single lung transplantation. The Journal of thoracic and cardiovascular surgery, 1998, Volume: 115, Issue:6 Topics: Animals; Blood Gas Analysis; Female; Follow-Up Studies; Lung; Lung Transplantation; Malondialdehyde;	1998
Pentoxifylline reduces injury of the brain in transient ischaemia. Acta cardiologica, 1998, Volume: 53, Issue:2 Topics: Animals; Brain; Evoked Potentials, Somatosensory; Ischemic Attack, Transient; Male; Neurologic Exami	1998
Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury. Clinica chimica acta; international journal of clinical chemistry, 1998, Jul-28, Volume: 275, Issue:2 Topics: Acetylcysteine; Animals; Catalase; Female; Free Radical Scavengers; Free Radicals; Glutathione; Glut	1998
Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1. The Journal of thoracic and cardiovascular surgery, 1999, Volume: 117, Issue:3 Topics: Animals; Blood Platelets; Female; Free Radical Scavengers; Lung; Lung Transplantation; Malondialdehy	1999
Lisofylline ameliorates intestinal mucosal barrier dysfunction caused by ischemia and ischemia/reperfusion. Shock (Augusta, Ga.), 1999, Volume: 11, Issue:4 Topics: Adenosine Triphosphate; Animals; Cell Membrane Permeability; Glutathione; Intestinal Mucosa; Intesti	1999
Amelioration of ischemia-reperfusion injury in rat intestine by pentoxifylline-mediated inhibition of xanthine oxidase. Journal of pediatric gastroenterology and nutrition, 1999, Volume: 29, Issue:1 Topics: Animals; Evaluation Studies as Topic; Free Radical Scavengers; Intestines; Lipid Peroxidation; Pento	1999
Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion. Brain research, 1999, Sep-18, Volume: 842, Issue:1 Topics: Animals; Benzyl Compounds; Blood-Brain Barrier; Blotting, Western; Collagen; Collagenases; Coloring	1999
Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury. Clinical biochemistry, 1999, Volume: 32, Issue:6 Topics: Animals; Catalase; Coenzymes; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hematologi	1999
Endotoxin-induced aggravation of preservation-reperfusion injury of rat liver and its modulation. Journal of hepatology, 2000, Volume: 32, Issue:1 Topics: Adenosine; Allopurinol; Animals; Bile; Clodronic Acid; Cryopreservation; Dose-Response Relationship,	2000
Lisofylline ameliorates intestinal and hepatic injury induced by hemorrhage and resuscitation in rats. Critical care medicine, 2000, Volume: 28, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Cell Membrane Permeability; E	2000
May pentoxifylline improve lung function after one-lung flooding? Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 2001, Volume: 200, Issue:2 Topics: Animals; Cell Movement; Endothelium, Vascular; Female; Intraoperative Complications; Lung; Neutrophi	2001
Pentoxifylline reduces coronary leukocyte accumulation early in reperfusion after cold ischemia. The Annals of thoracic surgery, 2001, Volume: 71, Issue:4 Topics: Animals; Cardioplegic Solutions; Coronary Vessels; Disease Models, Animal; Heart Arrest, Induced; Le	2001
Controlled perfusion of the transplanted lung. The Annals of thoracic surgery, 2001, Volume: 71, Issue:5 Topics: Animals; Humans; Lung Transplantation; Pentoxifylline; Reperfusion; Reperfusion Injury; Treatment Ou	2001
Preventive effect of inhaled nitric oxide and pentoxifylline on ischemia/reperfusion injury after lung transplantation. Transplantation, 2001, May-15, Volume: 71, Issue:9 Topics: Administration, Inhalation; Drug Therapy, Combination; Humans; Lung; Lung Transplantation; Nitric Ox	2001
Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model. British journal of pharmacology, 2001, Volume: 133, Issue:6 Topics: Alkaloids; Animals; Animals, Newborn; Apoptosis; Astrocytes; Carbazoles; Cell Survival; Cyclic GMP;	2001
The effect of pentoxifylline on intestinal ischemia/reperfusion injury. Fundamental & clinical pharmacology, 2001, Volume: 15, Issue:1 Topics: Animals; Biomarkers; Free Radical Scavengers; Free Radicals; Glutathione; Ileum; Intestinal Mucosa;	2001
Effect of pentoxifylline on ischemic acute renal failure in rabbits. Renal failure, 2001, Volume: 23, Issue:6 Topics: Acute Kidney Injury; Animals; Depression, Chemical; Kidney; Male; Monosaccharide Transport Proteins;	2001
Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits. Spinal cord, 2002, Volume: 40, Issue:5 Topics: Animals; Antioxidants; Aortic Diseases; Arterial Occlusive Diseases; Biomarkers; Cytokines; Disease	2002
Pentoxifylline attenuates reperfusion injury in testicular torsion. Scandinavian journal of urology and nephrology, 2002, Volume: 36, Issue:1 Topics: Animals; Free Radical Scavengers; Lipid Peroxidation; Male; Malondialdehyde; Pentoxifylline; Rats; R	2002
Effect of pentoxiphylline on the recovery of the preserved rat liver: 31P NMR and ultrastructural studies. NMR in biomedicine, 1991, Volume: 4, Issue:6 Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cryopreservation; Erythrocytes; Ischemia;	1991
Pentoxifylline in the isolated perfused rat kidney. Transplantation, 1990, Volume: 49, Issue:5 Topics: Animals; Kidney Function Tests; Kidney Transplantation; Organ Preservation; Pentoxifylline; Rats; Ra	1990
Protective effect of vasodilators on liver function after long hypothermic preservation: a study in the isolated perfused rat liver. Hepatology (Baltimore, Md.), 1989, Volume: 9, Issue:6 Topics: Animals; Bile; Hemodynamics; In Vitro Techniques; Liver; Liver Circulation; Liver Transplantation; M	1989

pentoxifylline and Injury, Ischemia-Reperfusion