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pentoxifylline and Infant, Premature, Diseases

pentoxifylline has been researched along with Infant, Premature, Diseases in 12 studies

Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.

Research Excerpts

ExcerptRelevanceReference
" Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but pharmacokinetic data in this population are extremely limited."9.30Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes. ( Batty, KT; Doherty, DA; Hibbert, J; Manning, L; Page-Sharp, M; Patole, S; Salman, S; Simmer, K; Strunk, T, 2019)
"To evaluate the influence of the methylxanthine derivative, pentoxifylline, on plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in prematurely delivered infants with generalized bacterial infections and to assess the effect of this immunomodulating drug on the clinical outcome in newborns with sepsis."9.09Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial. ( Helwich, E; Kowalczyk, D; Ksycínski, W; Lauterbach, R; Pawlik, D; Zembala, M, 1999)
"Pentoxifylline (Trental, 5 mg/kg/h for 6 h) was administered to 17 premature infants with sepsis, on 3 successive days."9.07Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations. ( Cholewa, B; Lauterbach, R; Pawlik, D; Tomaszczyk, B, 1994)
"Pentoxifylline (PTX) is a candidate adjuvant medication for the treatment of sepsis and necrotizing enterocolitis in preterm infants."7.96Intravenous pentoxifylline is well tolerated in critically ill preterm infants with sepsis or necrotizing enterocolitis. ( Berger, A; Kempf, K; Schüller, SS; Strunk, T; Unterasinger, L, 2020)
" Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but pharmacokinetic data in this population are extremely limited."5.30Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes. ( Batty, KT; Doherty, DA; Hibbert, J; Manning, L; Page-Sharp, M; Patole, S; Salman, S; Simmer, K; Strunk, T, 2019)
"To evaluate the efficacy and safety of nebulized pentoxifylline for reducing the duration of oxygen supplementation in extremely preterm neonates at high risk of bronchopulmonary dysplasia (BPD)."5.20Nebulized pentoxifylline for reducing the duration of oxygen supplementation in extremely preterm neonates. ( Deshmukh, M; Doherty, DA; Nathan, EA; Patole, SK; Schulzke, SM, 2015)
"To evaluate the influence of the methylxanthine derivative, pentoxifylline, on plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in prematurely delivered infants with generalized bacterial infections and to assess the effect of this immunomodulating drug on the clinical outcome in newborns with sepsis."5.09Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial. ( Helwich, E; Kowalczyk, D; Ksycínski, W; Lauterbach, R; Pawlik, D; Zembala, M, 1999)
"Pentoxifylline (Trental, 5 mg/kg/h for 6 h) was administered to 17 premature infants with sepsis, on 3 successive days."5.07Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations. ( Cholewa, B; Lauterbach, R; Pawlik, D; Tomaszczyk, B, 1994)
"Pentoxifylline (PTX) is a candidate adjuvant medication for the treatment of sepsis and necrotizing enterocolitis in preterm infants."3.96Intravenous pentoxifylline is well tolerated in critically ill preterm infants with sepsis or necrotizing enterocolitis. ( Berger, A; Kempf, K; Schüller, SS; Strunk, T; Unterasinger, L, 2020)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (50.00)18.2507
2000's1 (8.33)29.6817
2010's4 (33.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Schüller, SS1
Kempf, K1
Unterasinger, L1
Strunk, T2
Berger, A1
Salman, S1
Hibbert, J1
Page-Sharp, M1
Manning, L1
Simmer, K1
Doherty, DA2
Patole, S1
Batty, KT1
Schulzke, SM2
Kaempfen, S1
Patole, SK2
Deshmukh, M1
Nathan, EA1
Harpavat, S1
Pammi, M1
Gilger, M1
Mohan, PV1
Tarnow-Mordi, W1
Stenson, B1
Brocklehurst, P1
Haque, K1
Cavendish, V1
Cust, A1
Lauterbach, R5
Pawlik, D2
Tomaszczyk, B1
Cholewa, B1
Zembala, M2
Zimmerman, JJ1
Kowalczyk, D1
Ksycínski, W1
Helwich, E1
Szymura-Oleksiak, J1

Reviews

4 reviews available for pentoxifylline and Infant, Premature, Diseases

ArticleYear
Pentoxifylline for the prevention of bronchopulmonary dysplasia in preterm infants.
    The Cochrane database of systematic reviews, 2014, Nov-24, Issue:11

    Topics: Bronchopulmonary Dysplasia; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infant, Pre

2014
Novel treatments for NEC: keeping IBD in mind.
    Current gastroenterology reports, 2012, Volume: 14, Issue:5

    Topics: Enterocolitis, Necrotizing; Glucocorticoids; Humans; Infant, Newborn; Infant, Premature; Infant, Pre

2012
Can polyclonal intravenous immunoglobulin limit cytokine mediated cerebral damage and chronic lung disease in preterm infants?
    Archives of disease in childhood. Fetal and neonatal edition, 2004, Volume: 89, Issue:1

    Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Brain Diseases; Chronic Disease; Cytokines; Humans

2004
Appraising the potential of pentoxifylline in septic premies.
    Critical care medicine, 1999, Volume: 27, Issue:4

    Topics: Critical Care; Cytokines; Drug Administration Schedule; Free Radical Scavengers; Humans; Infant, New

1999

Trials

6 trials available for pentoxifylline and Infant, Premature, Diseases

ArticleYear
Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes.
    British journal of clinical pharmacology, 2019, Volume: 85, Issue:1

    Topics: Administration, Intravenous; Body Weight; Drug Therapy, Combination; Enterocolitis, Necrotizing; Fem

2019
Nebulized pentoxifylline for reducing the duration of oxygen supplementation in extremely preterm neonates.
    The Journal of pediatrics, 2015, Volume: 166, Issue:5

    Topics: Bronchopulmonary Dysplasia; Continuous Positive Airway Pressure; Double-Blind Method; Female; Humans

2015
Pentoxifylline treatment of sepsis of premature infants: preliminary clinical observations.
    European journal of pediatrics, 1994, Volume: 153, Issue:9

    Topics: Gram-Negative Bacterial Infections; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, D

1994
Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis.
    European journal of pediatrics, 1996, Volume: 155, Issue:5

    Topics: Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Pentoxifylline; Prospective

1996
Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial.
    Critical care medicine, 1999, Volume: 27, Issue:4

    Topics: Adjuvants, Immunologic; Double-Blind Method; Drug Administration Schedule; Female; Free Radical Scav

1999
Nebulized pentoxifylline in successful treatment of five premature neonates with bronchopulmonary dysplasia.
    European journal of pediatrics, 1999, Volume: 158, Issue:7

    Topics: Administration, Inhalation; Bronchopulmonary Dysplasia; Drug Administration Schedule; Enzyme Inhibit

1999

Other Studies

2 other studies available for pentoxifylline and Infant, Premature, Diseases

ArticleYear
Intravenous pentoxifylline is well tolerated in critically ill preterm infants with sepsis or necrotizing enterocolitis.
    European journal of pediatrics, 2020, Volume: 179, Issue:8

    Topics: Critical Illness; Drug Administration Schedule; Enterocolitis, Necrotizing; Female; Humans; Infant,

2020
Pentoxifylline treatment of persistent pulmonary hypertension of newborn.
    European journal of pediatrics, 1993, Volume: 152, Issue:5

    Topics: Chronic Disease; Humans; Hypertension, Pulmonary; Infant, Newborn; Infant, Premature, Diseases; Pent

1993