pentoxifylline has been researched along with Hypertension in 38 studies
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the anti proteinuric effect of pentoxifylline in diabetic patients, we prospectively studied in 25 hypertensive type 2 diabetic patients with persistent microalbuminuria and normal renal function the impact of combining pentoxifylline with an angiotensin converting enzyme inhibitor, lisinopril, on urinary albumin excretion and compared the results with those obtained in a control group of 25 type 2 diabetic patients treated with lisinopril only." | 9.10 | Combination of pentoxifylline with angiotensin converting enzyme inhibitors produces an additional reduction in microalbuminuria in hypertensive type 2 diabetic patients. ( Harmankaya, O; Seber, S; Yilmaz, M, 2003) |
| "To test the effectiveness of pentoxifylline as a therapy for diabetic impotence." | 9.08 | Trial of pentoxifylline for diabetic impotence. ( Georgitis, WJ; Merenich, JA, 1995) |
| "Pentoxifylline directly alleviated hypertension in metabolic syndrome rats, at least in part, via amelioration of low-grade inflammation and inhibition of angiotensin system." | 7.81 | Pentoxifylline alleviates hypertension in metabolic syndrome: effect on low-grade inflammation and angiotensin system. ( Azhar, A; El-Bassossy, HM, 2015) |
| "Post-traumatic stress disorder (PTSD) is characterized by a disordered stress response and associated with increased cardiovascular disease risk." | 5.51 | Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α. ( Beltz, TG; Felder, RB; Guo, F; Johnson, AK; Wei, SG; Xue, B; Yu, Y, 2019) |
| "Proteinuria was diagnosed in 2003 (DPE 3." | 5.35 | [Clinical state of a patient with nephrotic proteinuria successfully treated with combined therapy with angiotensin II receptor antagonists and angiotensin II converting enzyme inhibitors and pentoxifylline]. ( Larczyński, W; Renke, M; Rutkowski, B; Rutkowski, P; Tylicki, L; Zietkiewicz, M, 2008) |
| "To investigate the anti proteinuric effect of pentoxifylline in diabetic patients, we prospectively studied in 25 hypertensive type 2 diabetic patients with persistent microalbuminuria and normal renal function the impact of combining pentoxifylline with an angiotensin converting enzyme inhibitor, lisinopril, on urinary albumin excretion and compared the results with those obtained in a control group of 25 type 2 diabetic patients treated with lisinopril only." | 5.10 | Combination of pentoxifylline with angiotensin converting enzyme inhibitors produces an additional reduction in microalbuminuria in hypertensive type 2 diabetic patients. ( Harmankaya, O; Seber, S; Yilmaz, M, 2003) |
| "To test the effectiveness of pentoxifylline as a therapy for diabetic impotence." | 5.08 | Trial of pentoxifylline for diabetic impotence. ( Georgitis, WJ; Merenich, JA, 1995) |
| "To evaluate the use of pentoxifylline to treat impotence in men with mild to moderate penile vascular insufficiency." | 5.07 | Treatment of vasculogenic sexual dysfunction with pentoxifylline. ( Korenman, SG; Viosca, SP, 1993) |
| "Pentoxifylline directly alleviated hypertension in metabolic syndrome rats, at least in part, via amelioration of low-grade inflammation and inhibition of angiotensin system." | 3.81 | Pentoxifylline alleviates hypertension in metabolic syndrome: effect on low-grade inflammation and angiotensin system. ( Azhar, A; El-Bassossy, HM, 2015) |
| "Our objective was to determine whether two methylxanthines, pentoxifylline (PTX) and allopurinol, would have beneficial effects on experimental pregnancy-induced pre-eclampsia- like disease in ewes." | 3.71 | Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes. ( Németh, I; Pintér, S; Tálosi, G, 2001) |
| "For pentoxifylline-treated participants, the mean estimated GFR decrease during treatment was slower compared with the year before study enrollment (-9." | 2.74 | Effect of pentoxifylline on GFR decline in CKD: a pilot, double-blind, randomized, placebo-controlled trial. ( Aboudara, MC; Cushner, HM; Olson, SW; Perkins, RM; Uy, AL; Yuan, CM, 2009) |
| "Systemic arterial hypertension is a public health problem associated with an increased risk of cardiovascular disease." | 1.56 | TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure. ( Amaral, JH; Bonacio, GF; Dellalibera-Joviliano, R; Franca, SC; Garcia, VT; Mattos, BR; Rizzi, E; Tanus-Santos, JE; Vitorino, TR, 2020) |
| "Post-traumatic stress disorder (PTSD) is characterized by a disordered stress response and associated with increased cardiovascular disease risk." | 1.51 | Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α. ( Beltz, TG; Felder, RB; Guo, F; Johnson, AK; Wei, SG; Xue, B; Yu, Y, 2019) |
| "Pentoxifylline (PTX) is a potent antioxidant." | 1.42 | An evaluation of the effect of pentoxifylline on blood pressure and myocardial oxidative status following intake of western diet. ( Al-Taleb, Z; Alzoubi, KH; Mayyas, F, 2015) |
| "Proteinuria was diagnosed in 2003 (DPE 3." | 1.35 | [Clinical state of a patient with nephrotic proteinuria successfully treated with combined therapy with angiotensin II receptor antagonists and angiotensin II converting enzyme inhibitors and pentoxifylline]. ( Larczyński, W; Renke, M; Rutkowski, B; Rutkowski, P; Tylicki, L; Zietkiewicz, M, 2008) |
| "Hemoglobinopathies were involved in 14." | 1.28 | [Retino-vitreous hemorrhage in hemoglobinopathies]. ( Coulibaly, D; Pichard, E; Resnikoff, S; Serre, L, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (28.95) | 18.7374 |
| 1990's | 7 (18.42) | 18.2507 |
| 2000's | 7 (18.42) | 29.6817 |
| 2010's | 11 (28.95) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, XF | 1 |
| Li, JD | 1 |
| Huo, YL | 1 |
| Zhang, YP | 1 |
| Fang, ZQ | 1 |
| Wang, HP | 1 |
| Peng, W | 1 |
| Johnson, AK | 2 |
| Xue, B | 2 |
| Mattos, BR | 1 |
| Bonacio, GF | 1 |
| Vitorino, TR | 1 |
| Garcia, VT | 1 |
| Amaral, JH | 1 |
| Dellalibera-Joviliano, R | 1 |
| Franca, SC | 1 |
| Tanus-Santos, JE | 1 |
| Rizzi, E | 1 |
| Plotnikov, MB | 3 |
| Aliev, OI | 3 |
| Shamanaev, AY | 3 |
| Sidekhmenova, AV | 3 |
| Anfinogenova, Y | 2 |
| Anishchenko, AM | 3 |
| Fomina, TI | 1 |
| Arkhipov, AM | 2 |
| Yu, Y | 1 |
| Wei, SG | 1 |
| Beltz, TG | 1 |
| Guo, F | 1 |
| Felder, RB | 1 |
| Yavari, V | 1 |
| Ostovan, MA | 1 |
| Kojuri, J | 1 |
| Afshariani, R | 1 |
| Hamidian Jahromi, A | 1 |
| Hamidian, A | 1 |
| Roozbeh, J | 1 |
| Pakfetrat, M | 1 |
| Song, XA | 1 |
| Jia, LL | 1 |
| Cui, W | 1 |
| Zhang, M | 1 |
| Chen, W | 1 |
| Yuan, ZY | 1 |
| Guo, J | 1 |
| Li, HH | 1 |
| Zhu, GQ | 1 |
| Liu, H | 1 |
| Kang, YM | 1 |
| Azhar, A | 1 |
| El-Bassossy, HM | 1 |
| Mayyas, F | 1 |
| Alzoubi, KH | 1 |
| Al-Taleb, Z | 1 |
| Zhang, X | 1 |
| Meng, F | 1 |
| Song, J | 1 |
| Zhang, L | 1 |
| Wang, J | 1 |
| Li, D | 1 |
| Li, L | 1 |
| Dong, P | 1 |
| Yang, B | 1 |
| Chen, Y | 1 |
| Nosarev, AV | 1 |
| Pushkina, EV | 1 |
| Pena-Polanco, JE | 1 |
| Fried, LF | 1 |
| Renke, M | 1 |
| Rutkowski, P | 1 |
| Tylicki, L | 1 |
| Zietkiewicz, M | 1 |
| Larczyński, W | 1 |
| Rutkowski, B | 1 |
| Perkins, RM | 1 |
| Aboudara, MC | 1 |
| Uy, AL | 1 |
| Olson, SW | 1 |
| Cushner, HM | 1 |
| Yuan, CM | 1 |
| Gohel, MS | 1 |
| Davies, AH | 1 |
| Harmankaya, O | 1 |
| Seber, S | 1 |
| Yilmaz, M | 1 |
| Badenhorst, D | 1 |
| Anamourlis, C | 1 |
| Gibbs, M | 1 |
| Maseko, M | 1 |
| Osadchii, O | 1 |
| Woodiwiss, AJ | 1 |
| Norton, GR | 1 |
| Lipsitz, EC | 1 |
| Kim, S | 1 |
| Heidrich, H | 1 |
| Atroshchenko, ES | 1 |
| Georgitis, WJ | 1 |
| Merenich, JA | 1 |
| Korenman, SG | 1 |
| Viosca, SP | 1 |
| Goodfield, M | 1 |
| Frantz, RP | 1 |
| Edwards, BS | 1 |
| Olson, LJ | 1 |
| Schwab, MK | 1 |
| Adams, TF | 1 |
| Textor, SC | 1 |
| Daly, RC | 1 |
| McGregor, CG | 1 |
| Rodeheffer, RJ | 1 |
| Mchedlishvili, G | 1 |
| Tsinamdzvrihvili, B | 1 |
| Momtselidze, N | 1 |
| Beritashvili, N | 1 |
| Tálosi, G | 1 |
| Németh, I | 1 |
| Pintér, S | 1 |
| Regensteiner, JG | 1 |
| Hiatt, WR | 1 |
| Dembowski, U | 1 |
| Marx-Heep, I | 1 |
| Adams, HJ | 1 |
| Pichard, E | 1 |
| Resnikoff, S | 1 |
| Serre, L | 1 |
| Coulibaly, D | 1 |
| Gordeev, AV | 1 |
| Sura, VV | 1 |
| Savitskiĭ, SN | 1 |
| Tikhonov, VP | 1 |
| Statsenko, ME | 1 |
| Khrapova, EV | 1 |
| Lebedeva, NV | 1 |
| Trimarco, B | 1 |
| Lembo, G | 1 |
| De Luca, N | 1 |
| Ricciardelli, B | 1 |
| Rosiello, G | 1 |
| Volpe, M | 1 |
| Orofino, G | 1 |
| Condorelli, M | 1 |
| Quirk, WS | 1 |
| Dengerink, HA | 1 |
| Bademian, MJ | 1 |
| Hall, KW | 1 |
| Wright, JW | 1 |
| Iunusov, RA | 1 |
| Burykh, LN | 1 |
| Sviridova, NI | 1 |
| Shoĭkhet, IN | 1 |
| Treĭvish, VS | 1 |
| Novikova, NN | 1 |
| Rafibekova, ZhS | 1 |
| Radzvilovskaia, ME | 1 |
| Bobusheva, GS | 1 |
| Dzhumagulova, AS | 1 |
| Solerte, SB | 1 |
| Adamo, S | 1 |
| Viola, C | 1 |
| Zambianchi, E | 1 |
| Ferrari, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pentoxifylline and Progression of Chronic Kidney Disease in Moderate-to-high Risk Patients: a Pilot Randomized, Placebo-controlled, Double-blind Trial.[NCT00285298] | Phase 3 | 39 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for pentoxifylline and Hypertension
| Article | Year |
|---|---|
Established and Emerging Strategies in the Treatment of Chronic Kidney Disease.
Topics: Allopurinol; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bicarbonate | 2016 |
Pharmacological treatment in patients with C4, C5 and C6 venous disease.
Topics: Calcium Dobesilate; Cardiology; Chronic Disease; Compression Bandages; Drug Therapy; Flavonoids; Hum | 2010 |
[Peripheral arterial occlusions. Principles, possibilities and limits of conservative therapy].
Topics: Ancrod; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Cardiomyopathies; Dextrans; Digitalis | 1981 |
Optimal management of chronic leg ulcers in the elderly.
Topics: Administration, Oral; Aged; Aging; Arterial Occlusive Diseases; Aspirin; Bandages; Combined Modality | 1997 |
Current medical therapies for patients with peripheral arterial disease: a critical review.
Topics: Angiotensin-Converting Enzyme Inhibitors; Arteriosclerosis; Cardiovascular Diseases; Cilostazol; Dia | 2002 |
8 trials available for pentoxifylline and Hypertension
| Article | Year |
|---|---|
The preventive effect of pentoxifylline on contrast-induced nephropathy: a randomized clinical trial.
Topics: Acute Kidney Injury; Adult; Amidohydrolases; Contrast Media; Fluid Therapy; Free Radical Scavengers; | 2014 |
Effect of pentoxifylline on GFR decline in CKD: a pilot, double-blind, randomized, placebo-controlled trial.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Chronic Dis | 2009 |
Combination of pentoxifylline with angiotensin converting enzyme inhibitors produces an additional reduction in microalbuminuria in hypertensive type 2 diabetic patients.
Topics: Aged; Albumins; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Blood Pressure; C | 2003 |
Trial of pentoxifylline for diabetic impotence.
Topics: Aged; Analysis of Variance; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; E | 1995 |
Treatment of vasculogenic sexual dysfunction with pentoxifylline.
Topics: Aged; Arterial Occlusive Diseases; Arteriosclerosis; Blood Pressure; Brachial Artery; Coitus; Comorb | 1993 |
Effects of pentoxifylline on renal function and blood pressure in cardiac transplant recipients: a randomized trial.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; Cyclosporine; Doubl | 1997 |
Effects of celiprolol on systemic and forearm circulation in hypertensive patients: a double-blind cross-over study versus metoprolol.
Topics: Adrenergic beta-Antagonists; Adult; Celiprolol; Double-Blind Method; Echocardiography; Female; Forea | 1987 |
[Pentoxifylline and arterial hypertension in diabetes mellitus: long-term results in randomized groups].
Topics: Diabetes Complications; Erythrocyte Deformability; Follow-Up Studies; Humans; Hypertension; Pentoxif | 1985 |
25 other studies available for pentoxifylline and Hypertension
| Article | Year |
|---|---|
Blockade of angiotensin-converting enzyme or tumor necrosis factor-α reverses maternal high-fat diet-induced sensitization of angiotensin II hypertension in male rat offspring.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animal Nutritional Physiological Phenomena | 2020 |
TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relat | 2020 |
Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development.
Topics: Animals; Blood Pressure; Blood Viscosity; Cerebrovascular Circulation; Diastole; Erythrocyte Aggrega | 2017 |
Pentoxifylline treatment enhances antihypertensive activity of captopril through hemorheological improvement in spontaneously hypertensive rats during development of arterial hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Blood Vi | 2017 |
Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Brain; Captopril; | 2019 |
Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats.
Topics: Animals; Cardiomegaly; Hypertension; Male; Neurotransmitter Agents; Paraventricular Hypothalamic Nuc | 2014 |
Pentoxifylline alleviates hypertension in metabolic syndrome: effect on low-grade inflammation and angiotensin system.
Topics: Angiotensin II; Animals; Disease Models, Animal; Hypertension; Inflammation; Male; Metabolic Syndrom | 2015 |
An evaluation of the effect of pentoxifylline on blood pressure and myocardial oxidative status following intake of western diet.
Topics: Animals; Antioxidants; Blood Pressure; Diet, Western; Disease Models, Animal; Free Radical Scavenger | 2015 |
Pentoxifylline Ameliorates Cardiac Fibrosis, Pathological Hypertrophy, and Cardiac Dysfunction in Angiotensin II-induced Hypertensive Rats.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Hypertension; Inflammation Mediators; Male; Pentoxi | 2016 |
Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline.
Topics: Animals; Arterial Pressure; Blood Viscosity; Cardiac Output; Erythrocyte Aggregation; Erythrocyte De | 2016 |
[Clinical state of a patient with nephrotic proteinuria successfully treated with combined therapy with angiotensin II receptor antagonists and angiotensin II converting enzyme inhibitors and pentoxifylline].
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Diabetes Mellitus, Type | 2008 |
A phosphodiesterase inhibitor promotes the premature development of adverse cardiac remodelling mediated by beta-adrenergic activation in hypertension.
Topics: Adrenergic beta-Agonists; Animals; Collagen; Dilatation, Pathologic; Drug Therapy, Combination; Echo | 2004 |
Antithrombotic therapy in peripheral arterial disease.
Topics: Anticoagulants; Aspirin; Atherosclerosis; Cilostazol; Clopidogrel; Comorbidity; Diabetic Angiopathie | 2008 |
[Capillary permeability in cardiovascular diseases based on radioindication data].
Topics: Adult; Arterial Occlusive Diseases; Capillary Permeability; Cardiovascular Diseases; Coronary Diseas | 1984 |
Kinetics of beneficial effect of pentoxifylline on persistent forms of arterial hypertension.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Erythrocyte Aggreg | 1998 |
Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes.
Topics: Albumins; Allopurinol; Animals; Bilirubin; Blood Pressure; Fasting; Female; Heme; Hypertension; Hypo | 2001 |
[Angioneuropathies, angiolopathies and other disorders of blood circulation. Treatment in ambulatory patients].
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Obes | 1979 |
[Retino-vitreous hemorrhage in hemoglobinopathies].
Topics: Adolescent; Adult; Diabetes Complications; Hemoglobin SC Disease; Hemoglobinopathies; Humans; Hypert | 1991 |
[Senile pyelonephritis with the arterial hypertension syndrome: the use of trental].
Topics: Dinoprost; Drug Evaluation; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Pentoxify | 1991 |
[Pharmacologic correction of the adverse effects of beta-adrenoblockaders on the kidneys in patients with hypertension].
Topics: Adult; Aged; Female; Humans; Hypertension; Ischemia; Kidney; Male; Middle Aged; Pentoxifylline; Prop | 1989 |
[Dynamics of blood serotonin contents in acute disorders of cerebral circulation and circulatory encephalopathy].
Topics: Adult; Aged; Aged, 80 and over; Brain Diseases; Cerebrovascular Disorders; Female; Humans; Hypertens | 1989 |
The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cochlea; Dose-Response Relationship, Drug; Hypertension; Infusions, Intrave | 1988 |
[Hemodynamic assessment of anti-angina preparations in treating patients with ischemic heart disease with hypertension].
Topics: Adult; Aged; Coronary Disease; Drug Evaluation; Drug Therapy, Combination; Female; Hemodynamics; Hum | 1987 |
[Pentoxifylline (Trental) in the treatment of chronic glomerulonephritis].
Topics: Adolescent; Adult; Chronic Disease; Drug Evaluation; Female; Glomerulonephritis; Humans; Hypertensio | 1986 |
[Experience with the use of trental in the treatment of essential hypertension].
Topics: Adult; Antihypertensive Agents; Blood Coagulation; Female; Humans; Hypertension; Male; Middle Aged; | 1985 |