pentoxifylline has been researched along with Graft-Versus-Host Disease in 14 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, neutralisation of TNF-alpha by an antibody or by pentoxifylline inhibits the occurrence of apoptosis and of mucosal atrophy in this animal model." | 7.70 | Intestinal crypt cell apoptosis in murine acute graft versus host disease is mediated by tumour necrosis factor alpha and not by the FasL-Fas interaction: effect of pentoxifylline on the development of mucosal atrophy. ( Arendt, T; Büschenfeld, A; Fölsch, UR; Stüber, E; von Freier, A, 1999) |
| " All patients received a regimen of methotrexate and cyclosporine as prophylaxis against acute graft-versus-host disease (GVHD)." | 5.07 | A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation. ( Appelbaum, FR; Bakke, L; Bensinger, WI; Bianco, JA; Bowden, RA; Buckner, CD; Clift, RA; McDonald, GB; Schubert, M; Singer, JW, 1993) |
| " However, neutralisation of TNF-alpha by an antibody or by pentoxifylline inhibits the occurrence of apoptosis and of mucosal atrophy in this animal model." | 3.70 | Intestinal crypt cell apoptosis in murine acute graft versus host disease is mediated by tumour necrosis factor alpha and not by the FasL-Fas interaction: effect of pentoxifylline on the development of mucosal atrophy. ( Arendt, T; Büschenfeld, A; Fölsch, UR; Stüber, E; von Freier, A, 1999) |
| "In a Phase I-II trial examining the effect of prophylactic administration of pentoxifylline (PTX) on bone marrow transplant-associated morbidity, there was an apparent reduction in the incidence and severity of acute graft-versus-host disease." | 3.68 | Effect of methylxanthine derivatives on T cell activation. ( Andrews, DF; Bianco, JA; Petersen, J; Simrell, C; Singer, JW; Takahashi, G, 1992) |
| "Pentoxifylline (PTX) is a methylxanthine derivative with a variety of anti-inflammatory effects." | 2.44 | Pentoxifylline: a drug with wide spectrum applications in dermatology. ( Zargari, O, 2008) |
| "The impact of infections due to cytomegalovirus has been reduced by more effective prevention in patients who are cytomegalovirus negative and reactivation in patients who are cytomegalovirus positive." | 2.38 | Supportive care in marrow transplantation. ( Bensinger, WI, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (78.57) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zargari, O | 1 |
| Neid, T | 1 |
| Danz, B | 1 |
| Eismann, R | 1 |
| Bramsiepe, I | 1 |
| Wohlrab, J | 1 |
| Marsch, WC | 1 |
| Fiedler, E | 1 |
| Nemunaitis, J | 2 |
| van der Jagt, RH | 1 |
| Pari, G | 1 |
| McDiarmid, SA | 1 |
| Boisvert, DM | 1 |
| Huebsch, LB | 1 |
| Hervé, P | 1 |
| Clift, RA | 1 |
| Bianco, JA | 4 |
| Appelbaum, FR | 2 |
| Buckner, CD | 2 |
| Singer, JW | 4 |
| Bakke, L | 1 |
| Bensinger, WI | 2 |
| Bowden, RA | 1 |
| McDonald, GB | 1 |
| Schubert, M | 1 |
| Ferrà, C | 1 |
| de Sanjosé, S | 1 |
| Lastra, CF | 1 |
| Martí, F | 1 |
| Mariño, EL | 1 |
| Sureda, A | 1 |
| Brunet, S | 1 |
| Gallardo, D | 1 |
| Berlanga, JJ | 1 |
| García, J | 1 |
| Grañena, A | 1 |
| Saigo, K | 1 |
| Ryo, R | 1 |
| Stüber, E | 1 |
| Büschenfeld, A | 1 |
| von Freier, A | 1 |
| Arendt, T | 1 |
| Fölsch, UR | 1 |
| List, AF | 1 |
| Maziarz, R | 1 |
| Stiff, P | 1 |
| Jansen, J | 1 |
| Liesveld, J | 1 |
| Andrews, F | 2 |
| Schuster, M | 1 |
| Wolff, S | 1 |
| Litzow, M | 1 |
| Karanes, C | 1 |
| Dahlberg, S | 1 |
| Kirkhart, B | 1 |
| Takahashi, G | 1 |
| Simrell, C | 1 |
| Petersen, J | 1 |
| Andrews, DF | 1 |
| Clift, R | 1 |
| Bianco, J | 1 |
| Petersen, F | 1 |
| Appelbaum, F | 1 |
| Almgren, J | 1 |
| Kettner, P | 1 |
| Shields, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata: a Clinical and Dermoscopic Study.[NCT06087796] | Phase 1 | 60 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for pentoxifylline and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Pentoxifylline: a drug with wide spectrum applications in dermatology.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifibrinolytic Agents; Behcet Syndrome; C | 2008 |
Recombinant hematopoietic growth factors in bone marrow transplantation.
Topics: Adjuvants, Immunologic; Animals; beta-Glucans; Bone Marrow Transplantation; Clinical Trials as Topic | 1995 |
Therapeutic strategy for post-transfusion graft-vs.-host disease.
Topics: Antirheumatic Agents; Chloroquine; Enzyme Inhibitors; Graft vs Host Disease; Humans; Immunosuppressi | 1999 |
Supportive care in marrow transplantation.
Topics: Adult; Anti-Bacterial Agents; Bone Marrow Purging; Bone Marrow Transplantation; Child; Graft vs Host | 1992 |
5 trials available for pentoxifylline and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Effect of pentoxifylline on regimen related toxicity in patients undergoing allogeneic or autologous bone marrow transplantation.
Topics: Administration, Oral; Adolescent; Adult; Bone Marrow Transplantation; Busulfan; Child; Cyclophospham | 1994 |
A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Cyclosporine; Cytomegalovirus Infections; Dou | 1993 |
Pentoxifylline, ciprofloxacin and prednisone failed to prevent transplant-related toxicities in bone marrow transplant recipients and were associated with an increased incidence of infectious complications.
Topics: Adolescent; Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Bacterial Infections; Bone Marro | 1997 |
A randomized placebo-controlled trial of lisofylline in HLA-identical, sibling-donor, allogeneic bone marrow transplant recipients. The Lisofylline Marrow Transplant Study Group.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Beha | 2000 |
Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation.
Topics: Acute Disease; Acute Kidney Injury; Adult; Bone Marrow Transplantation; Drug Administration Schedule | 1991 |
5 other studies available for pentoxifylline and Graft-Versus-Host Disease
| Article | Year |
|---|---|
[Sclerodermiform chronic graft-versus-host disease after allogenic peripheral blood stem-cell transplantation].
Topics: Anti-Infective Agents; Cyclosporine; Graft vs Host Disease; Humans; Immunosuppressive Agents; Laser- | 2009 |
Prevention and treatment of acute GvHD--new modalities.
Topics: Acute Disease; Antibodies, Monoclonal; Bone Marrow Transplantation; Combined Modality Therapy; Graft | 1993 |
Intestinal crypt cell apoptosis in murine acute graft versus host disease is mediated by tumour necrosis factor alpha and not by the FasL-Fas interaction: effect of pentoxifylline on the development of mucosal atrophy.
Topics: Animals; Apoptosis; Atrophy; Epithelial Cells; Fas Ligand Protein; Graft vs Host Disease; Intestinal | 1999 |
Effect of methylxanthine derivatives on T cell activation.
Topics: Antigens, Differentiation, T-Lymphocyte; Bone Marrow Transplantation; CD2 Antigens; CD3 Complex; Gra | 1992 |
Marrow transplantation in patients with acute myeloid leukemia.
Topics: Acute Disease; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Drug Administration Schedule | 1992 |