pentoxifylline has been researched along with Erythema Nodosum in 11 studies
Erythema Nodosum: An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The patients received PTX at the initiating dosage until complete clinical cure." | 6.71 | [Pentoxifylline in the treatment of erythema nodosum leprosum: results of an open study]. ( Achirafi, A; de Carsalade, GY; Flageul, B, 2003) |
| "Treatment with thalidomide provides an effective alternative to steroid therapy, gives better long-term control and avoids the adverse effects of prolonged steroid therapy." | 6.44 | The role of thalidomide in the management of erythema nodosum leprosum. ( Lockwood, DN; Walker, SL; Waters, MF, 2007) |
| "Thalidomide has been shown to be a highly effective drug for the treatment of ENL." | 2.73 | Double-blind trial of the efficacy of pentoxifylline vs thalidomide for the treatment of type II reaction in leprosy. ( de Matos, HJ; Duppre, NC; Nery, JA; Sales, AM; Sampaio, EP; Sarno, EN, 2007) |
| " The patients received PTX at the initiating dosage until complete clinical cure." | 2.71 | [Pentoxifylline in the treatment of erythema nodosum leprosum: results of an open study]. ( Achirafi, A; de Carsalade, GY; Flageul, B, 2003) |
| "Thalidomide has a rapid action but its use is limited due the teratogenicity and neurotoxicity." | 2.58 | Erythema Nodosum Leprosum: Update and challenges on the treatment of a neglected condition. ( Costa, PDSS; Daxbacher, ELR; Fraga, LR; Kowalski, TW; Schuler-Faccini, L; Vianna, FSL, 2018) |
| "Treatment with thalidomide provides an effective alternative to steroid therapy, gives better long-term control and avoids the adverse effects of prolonged steroid therapy." | 2.44 | The role of thalidomide in the management of erythema nodosum leprosum. ( Lockwood, DN; Walker, SL; Waters, MF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, PDSS | 1 |
| Fraga, LR | 1 |
| Kowalski, TW | 1 |
| Daxbacher, ELR | 1 |
| Schuler-Faccini, L | 1 |
| Vianna, FSL | 1 |
| Dawlah, ZM | 1 |
| Cabrera, A | 1 |
| Ahern, K | 1 |
| Levis, WR | 1 |
| De Carsalade, GY | 2 |
| Achirafi, A | 2 |
| Flageul, B | 2 |
| Sales, AM | 1 |
| de Matos, HJ | 1 |
| Nery, JA | 3 |
| Duppre, NC | 1 |
| Sampaio, EP | 3 |
| Sarno, EN | 3 |
| Walker, SL | 1 |
| Waters, MF | 1 |
| Lockwood, DN | 1 |
| Talhari, S | 1 |
| Orsi, AT | 1 |
| Talhari, AC | 1 |
| Souza, FH | 1 |
| Ferreira, LC | 1 |
| Garcia, CC | 1 |
| Moraes, MO | 1 |
| Santos, AR | 1 |
| Matos, HC | 1 |
| Moreira, AL | 1 |
| Kaplan, G | 1 |
| Villahermosa, LG | 1 |
| Fajardo, TJ | 1 |
| Abalos, RM | 1 |
| Cellona, RV | 1 |
| Balagon, MV | 1 |
| Tan, EV | 1 |
| Walsh, GP | 1 |
| Welsh, O | 1 |
| Gómez, M | 1 |
| Mancias, C | 1 |
| Ibarra-Leal, S | 1 |
| Millikan, LE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum (MaPS in ENL[NCT03775460] | 550 participants (Anticipated) | Interventional | 2023-01-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pentoxifylline and Erythema Nodosum
| Article | Year |
|---|---|
Erythema Nodosum Leprosum: Update and challenges on the treatment of a neglected condition.
Topics: Anti-Inflammatory Agents; Erythema Nodosum; Glucocorticoids; Humans; Inflammation; Leprostatic Agent | 2018 |
The role of thalidomide in the management of erythema nodosum leprosum.
Topics: Aspirin; Controlled Clinical Trials as Topic; Decision Trees; Erythema Nodosum; Humans; Leprostatic | 2007 |
5 trials available for pentoxifylline and Erythema Nodosum
| Article | Year |
|---|---|
A phase 2 open trial of pentoxifylline for the treatment of leprosy reactions.
Topics: Adult; Aged; Erythema Nodosum; Female; Humans; Leprosy, Borderline; Leprosy, Lepromatous; Leprosy, T | 2002 |
[Pentoxifylline in the treatment of erythema nodosum leprosum: results of an open study].
Topics: Adolescent; Adult; Erythema Nodosum; Female; Follow-Up Studies; Glucocorticoids; Humans; Immunosuppr | 2003 |
Double-blind trial of the efficacy of pentoxifylline vs thalidomide for the treatment of type II reaction in leprosy.
Topics: Adolescent; Adult; Double-Blind Method; Erythema Nodosum; Female; Humans; Leprostatic Agents; Lepros | 2007 |
Is pentoxifylline a viable alternative in the treatment of ENL?
Topics: Erythema Nodosum; Female; Humans; Leprosy, Borderline; Leprosy, Lepromatous; Male; Pentoxifylline; T | 1995 |
Pentoxifylline decreases in vivo and in vitro tumour necrosis factor-alpha (TNF-alpha) production in lepromatous leprosy patients with erythema nodosum leprosum (ENL).
Topics: Adolescent; Adult; Cells, Cultured; Erythema Nodosum; Female; Gene Expression; Humans; Leprosy, Lepr | 1998 |
4 other studies available for pentoxifylline and Erythema Nodosum
| Article | Year |
|---|---|
Pentoxifylline in the treatment of erythema nodosum leprosum.
Topics: Administration, Oral; Adolescent; Adult; Drug Administration Schedule; Erythema Nodosum; Female; Hum | 2003 |
Pentoxifylline may be useful in the treatment of type 2 leprosy reaction.
Topics: Erythema Nodosum; Humans; Leprosy, Lepromatous; Pentoxifylline; Vasodilator Agents | 1995 |
Comparison of pentoxifylline, thalidomide and prednisone in the treatment of ENL.
Topics: Adolescent; Adult; Cytokines; Erythema Nodosum; Female; Humans; Leprosy, Lepromatous; Male; Pentoxif | 1998 |
A new therapeutic approach to type II leprosy reaction.
Topics: Adult; Aged; Clofazimine; Drug Therapy, Combination; Erythema Nodosum; Female; Humans; Leprostatic A | 1999 |