pentoxifylline has been researched along with Disease Models, Animal in 262 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The goal in this study was to investigate the effect of pentoxifylline on vasospasm in an experimental subarachnoid hemorrhage model." | 8.02 | The effect of pentoxifylline on cerebral vasospasm following experimental subarachnoid hemorrhage. ( Akalan, N; Bahadir, S; Başar, I; Bilginer, B; Hanalioğlu, Ş; Narin, F, 2021) |
| " The aim of this study was to investigate the effects of pentoxifylline (PTX) on the zone of stasis in burns and burn wound healing." | 7.91 | Salvaging the Zone of Stasis in Burns by Pentoxifylline: An Experimental Study in Rats. ( Coruh, A; Deniz, K; Yucel, B, 2019) |
| "Our findings demonstrate that pentoxifylline may be promising in preventing small bowel ischemia-reperfusion injury." | 7.88 | Role of pentoxifylline and iloprost in the prevention of ischemia-reperfusion injury in an experimental model of intestine ischemia-reperfusion in rats. ( Abakay, U; Çakmak, E; Genç, HÇ; Göksel, S; Korkmaz, Ö; Kurt, A; Şahin İnan, ZD; Saraç, B; Soylu, S, 2018) |
| "To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR)." | 7.85 | The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats. ( Fagundes, DJ; Monteiro, HP; Oliveira, GF; Oliveira, TRR; Simões, RS; Taha, MO; Tikazawa, EH, 2017) |
| "Our results suggest that the oral administration of pentoxifylline may be an alternative to current therapies for endometriosis." | 7.85 | Oral Administration of Pentoxifylline Reduces Endometriosis-Like Lesions in a Nude Mouse Model. ( Balasch, J; Carmona, F; Castillo, P; González-Foruria, I; Lozano, F; Martínez-Florensa, M; Perelló, M, 2017) |
| "This study was designed to identify the effect of pentoxifylline on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats." | 7.85 | Pentoxifylline attenuates mucosal damage in an experimental model of rat colitis by modulating tissue biomarkers of inflammation, oxidative stress, and fibrosis. ( Arhan, M; Ekinci, Ö; Erdal, H; G Dumlu, Ş; Gül Utku, Ö; Ibiş, M; Karatay, E; Önal, İK; Yilmaz Demirtaş, C, 2017) |
| "Data presented showed that pentoxifylline attenuates microcirculatory disturbances at the mesenteric bed with significant minimization of lung inflammation after a double-injury model of hemorrhagic shock and reperfusion followed by sepsis." | 7.81 | Pentoxifylline attenuates leukocyte-endothelial interactions in a two-hit model of shock and sepsis. ( Aikawa, P; Correia, CJ; Cruz, JW; Cruz, RJ; Mauad, T; Nakagawa, NK; Rocha-e-Silva, M; Sannomiya, P; Zhang, H, 2015) |
| "Pentoxifylline directly alleviated hypertension in metabolic syndrome rats, at least in part, via amelioration of low-grade inflammation and inhibition of angiotensin system." | 7.81 | Pentoxifylline alleviates hypertension in metabolic syndrome: effect on low-grade inflammation and angiotensin system. ( Azhar, A; El-Bassossy, HM, 2015) |
| "To investigate the action of pentoxifylline (PTX) and prostaglandin E1 (PGE1) on ischemia and reperfusion of small intestine tissue in rats, using immunohistochemical analysis." | 7.81 | Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small intestine tissue in rats. An immunohistochemical study. ( Assis, PV; Aydos, RD; Brasileiro, JL; Marks, G; Ramalho, RT; Silva, IS; Takita, LC, 2015) |
| "We have previously shown that pentoxifylline (PTX) protects from vascular complications associated with insulin resistance (IR)." | 7.80 | Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance. ( Azhar, A; El-Bassossy, HM, 2014) |
| " Administration of pentoxifylline reduced the collagen density caused by ischemic priapism in groups 3, 4 and 5 compared with group 2." | 7.80 | The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model. ( Atilgan, D; Erdemir, F; Firat, F; Gencten, Y; Kuyucu, YE; Markoc, F; Parlaktas, BS, 2014) |
| "The role of phosphodiesterase inhibitor, pentoxifylline, in the prevention of cyclophosphamide-induced hemorrhagic cystitis was evaluated in a rat model." | 7.79 | Uroprotective effect of pentoxifylline in cyclophosphamide-induced hemorrhagic cystitis in rats. ( Abo-Salem, OM, 2013) |
| "We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor." | 7.77 | Pretreatment with pentoxifylline has antidepressant-like effects in a rat model of acute myocardial infarction. ( Bah, TM; Godbout, R; Kaloustian, S; Rousseau, G, 2011) |
| "To investigate the effects of pentoxifylline, on vascular endothelial growth factor (VEGF)-C and flk-1 expression in the rat endometriosis model." | 7.76 | Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model. ( Creatsas, G; Deliveliotou, A; Gregoriou, O; Lai, J; Perrea, D; Vlachos, A; Vlahos, NF; Zhao, Y, 2010) |
| "Pentoxifylline (PTX) has been shown to inhibit renal inflammation in a rat model of crescentic glomerulonephritis." | 7.75 | Pentoxifylline inhibits transforming growth factor-beta signaling and renal fibrosis in experimental crescentic glomerulonephritis in rats. ( Chen, YM; Lan, HY; Lan, XR; Ng, YY; Tsai, TJ; Yang, WC, 2009) |
| "Two PDE inhibitors including cilostazol a PDE3 inhibitor (40 and 400 mg/kg), and pentoxifylline (PTX), a PDE 1-5 inhibitor (50 and 500 mg/kg) were used for a period of 7 days to inhibit angiogenesis, inflammation, and fibrosis in a murine model of sponge-induced peritoneal adhesion." | 7.75 | Cilostazol and pentoxifylline decrease angiogenesis, inflammation, and fibrosis in sponge-induced intraperitoneal adhesion in mice. ( Andrade, SP; Campos, PP; Mendes, JB; Rocha, MA, 2009) |
| "We investigated the effects of iloprost and pentoxifylline on skeletal muscle ischemia-reperfusion injury in a rabbit model." | 7.74 | Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model. ( Aksun, M; Bozok, S; Emrecan, B; Gürbüz, A; Ozcan, AV; Saçar, M; Tulukoğlu, E; Yağdi, S, 2008) |
| "These results indicate pentoxifylline diminishes leukocyte-endothelium interaction, and may have a therapeutic role in preventing ischemia reperfusion injury in microsurgical operations." | 7.74 | In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury. ( Dalcik, H; Iscen, D; Sen, C; Unal, C, 2007) |
| "Elucidate the mechanisms of induction of delayed diarrhea and determine the effects of the cytokine production inhibitor pentoxifylline (PTX) and thalidomide (TLD) in the experimental model of intestinal mucositis, induced by CPT-11." | 7.74 | Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide. ( Brito, GA; Carvalho, SB; Cunha, FQ; Melo, ML; Ribeiro, RA; Silva, JV; Soares, PM; Soares, RC; Souza, MH; Vale, ML, 2008) |
| " We hypothesized that the anti-inflammatory agent pentoxifylline (PTX) attenuates postresuscitative lung injury through modulation of transcription factors after hemorrhagic shock." | 7.74 | Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock. ( Coimbra, R; de Campos, T; Deree, J; Loomis, WH; Martins, J; Putnam, JG; Wolf, P, 2007) |
| "The neuroprotective effects of pentoxifylline (PTX) against lithium-pilocarpine (Li-Pc)-induced status epilepticus (SE) in young rats are described." | 7.74 | Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats. ( Ahmad, M; Deeb, SA; Moutaery, KA; Tariq, M, 2008) |
| "To investigate whether pentoxifylline (PTX) could influence the increased cytokine gene expression in the retina flowing transient ischemia, and if so, whether it acts through the modulation of nuclear factor kappa B (NF-kappaB) activation." | 7.73 | Pentoxifylline decreases up-regulated nuclear factor kappa B activation and cytokine production in the rat retina following transient ischemia. ( Ji, Q; Jia, H; Lv, R; Xu, J; Zhang, L, 2006) |
| "To evaluate the efficiency of pentoxifylline (PTX), a methyl xanthine derivative, in preventing renal scar formation after the induction of pyelonephritis in an experimental rat model with delayed antimicrobial therapy." | 7.72 | Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis. ( Boleken, ME; Dindar, H; Ertoy, D; Gokcora, IH; Ozsan, M; Yagmurlu, A, 2003) |
| "The influence and relation between pentoxifylline (PTX) dose and time of administration and mortality rate of animals with experimental peritonitis (EP) were studied." | 7.72 | [The influence of pentoxifylline on the course of experimental peritonitis]. ( Czarnecki, P; Markert, R; Modzelewski, B, 2004) |
| "The aim of this study was to investigate whether the methylxanthine-derivative pentoxifylline (PTX) affects bacterial clearance of the organism in states of hemorrhage and endotoxemia." | 7.70 | Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia. ( Heller, A; Heller, S; Koch, T; Urbaschek, R; Weber, K, 1999) |
| "To assess the effects of pentoxifylline posttreatment on hemodynamic variables and acute pulmonary injury in the rat intestinal ischemia-reperfusion (I-R) model, using a recently developed method of fluorescent intravital pulmonary videomicroscopy." | 7.69 | Pentoxifylline attenuates pulmonary macromolecular leakage after intestinal ischemia-reperfusion. ( Carter, MB; Garrison, RN; Wead, WB; Wilson, MA, 1995) |
| "The influence of pentoxifylline (PTX) on mortality and some important mediators was studied in a model of cecal perforation with fulminant intra-abdominal sepsis in rats." | 7.69 | Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats. ( Ekstrøm, P; Giercksky, KE; Lundblad, R, 1995) |
| "To investigate the benefit of pentoxifylline in severe experimental pancreatitis." | 7.69 | Failure of pentoxifylline to ameliorate severe acute pancreatitis in the rat: results of a prospective, randomized, controlled study. ( Bassi, DG; Fernández-del Castillo, C; Foitzik, T; Lewandrowski, K; Rattner, DW; Warshaw, AL, 1994) |
| "The aim of this study was to evaluate the effects of two xanthine derivates, pentoxifylline (PTX) and its more metabolically stable analogue, albifylline (HWA 138), on hepatic sinusoidal perfusion and leukocyte endothelial interactions in the liver after hemorrhagic shock." | 7.69 | Influence of pentoxifylline and albifylline on liver microcirculation and leukocyte adhesion after hemorrhagic shock in the rat. ( Bauer, M; Herzog, C; Maier, M; Marzi, I, 1996) |
| " Oral feeding of yellow phosphorus to pigs reproducibly results in fibrosis after 8 weeks of feeding, extensive fibrosis after 12 weeks and cirrhosis after 16 weeks of yellow phosphorus." | 7.69 | Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism. ( Neumeister, M; Peterson, TC, 1996) |
| "To investigate whether pentoxifylline could play a role in attenuation of the hazardous effects of ischemia/reperfusion on corporeal tissue in a rat model of veno-occlusive priapism (VOP)." | 7.69 | Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissue lipid peroxidation in a rat model. ( Evliyaoğlu, Y; Kaya, B; Kayrin, L, 1997) |
| "The aim of this study was to determine the effects of pentoxifylline (Ptx) in reperfusion injury of the small bowel as a leukocyte stabilizer, free radical scavenger, and microcirculatory regulator." | 7.69 | Pentoxifylline inhibits overflow and reduces intestinal reperfusion injury. ( Aras, T; Ataoğlu, O; Bilgehan, A; Cakmak, M; Dindar, H; Ozgüner, F; Savaş, C; Türközkan, N; Yücesan, S, 1997) |
| "The effect of acute pentoxifylline treatment in an experimental model of colitis was assessed using the trinitrobenzene sulphonic acid (TNBS)-induced rat model of colitis." | 7.69 | Effect of acute pentoxifylline treatment in an experimental model of colitis. ( Davey, K; Peterson, TC, 1997) |
| "To compare effects of a single dose of pentoxifylline (PTX), flunixin meglumine (FM), and their combination (FM/PTX) in a model of equine endotoxemia." | 7.69 | Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses. ( Anders, B; Barton, MH; Baskett, A; Moore, JN; Norton, N, 1997) |
| "In this acute, nonresuscitated, canine hemorrhagic shock model, pentoxifylline did not act as a vasodilator, or have any significant effect on HR, cardiac output, oxygen transport, or lactic acidosis." | 7.68 | Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock. ( Amin, D; Benjamin, E; Fischer, E; Iberti, TJ; Jacobs, E; Klapholtz, A; Oropello, JM, 1991) |
| " The effect of the haemorrheological agent pentoxifylline was investigated in a canine model of acute myocardial infarction, induced by occlusion of the left anterior descending coronary for 6 h." | 7.67 | Pentoxifylline does not reduce infarct size in a canine model of acute myocardial infarction. ( Campbell, CA; Clavenna, CF; Kloner, RA; Wynne, J, 1988) |
| "Among the microvascular complications, diabetic nephropathy is the most frequent cause of end-stage renal disease." | 6.44 | Efficacy of pentoxifylline in the management of microalbuminuria in patients with diabetes. ( Guerrero-Romero, F; Rodríguez-Morán, M, 2008) |
| "Cardiac inflammation was interrogated via expression levels of TNF α, interleukins 6 and 10, phosphorylated STAT4 and lipoxygenases 12 and 12/15." | 5.62 | Lisofylline mitigates cardiac inflammation in a mouse model of obesity through improving insulin secretion and activating cardiac AMPK signaling pathway. ( Abdelzaher, LA; Ali, M; Bakr, MH; Desai, AA; Mali, V; Radwan, E; Sayed, SA, 2021) |
| "Post-traumatic stress disorder (PTSD) is characterized by a disordered stress response and associated with increased cardiovascular disease risk." | 5.51 | Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α. ( Beltz, TG; Felder, RB; Guo, F; Johnson, AK; Wei, SG; Xue, B; Yu, Y, 2019) |
| "Treatment with pentoxifylline significantly recovered the cerebral ischemia reperfusion‑induced neurological deficit score and cerebral infarct volume in rats." | 5.48 | Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway. ( Dong, J; Xie, W; Yuan, X, 2018) |
| "The effective treatments of endotoxemia are necessary to prevent high mortality rates." | 5.43 | The comparative efficacy of tyloxapol versus pentoxifylline against induced acute phase response in an ovine experimental endotoxemia model. ( Badiei, K; Chalmeh, A; Heidari, SM; Nazifi, S; Pourjafar, M; Rahmani Shahraki, A; Zamiri, MJ, 2016) |
| "Pentoxifylline (PTX) is a methylxanthine derivative clinically proven to improve perfusion in the peripheral microcirculation and has been shown to have neuroprotective effects in brain trauma and global cerebral ischemia in experimental animal models." | 5.43 | Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage. ( Aslan, M; Demır, N; Dilmac, S; Dogan, O; Goksu, E; Kirac, E; Konuk, E; Tanrıover, G; Ulker, P, 2016) |
| "Anti-Thy1 glomerulonephritis is a rat nephritis model closely simulating human mesangial proliferative glomerulonephritis." | 5.42 | Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling. ( Chen, YM; Chiang, WC; Lai, CF; Lin, SL; Wu, KD; Yang, Y, 2015) |
| " Additionally, the effects of chronic administration of the tricyclic antidepressant imipramine and the anti-TNF-α pentoxyphylline were investigated." | 5.40 | Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. ( Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK, 2014) |
| "Pentoxifylline (PTX) is a derivative of methylxanthine and is used in peripheral vascular and cerebrovascular diseases for its effect on the regulation of blood circulation." | 5.38 | Effect of pentoxifylline on histopathological changes in steroid-induced osteonecrosis of femoral head: experimental study in chicken. ( Aktas, M; Erken, HY; Ofluoglu, O; Topal, C; Yildiz, M, 2012) |
| "The mean lung injury score was 1." | 5.38 | The effectiveness of hypertonic saline and pentoxifylline (HTS-PTX) resuscitation in haemorrhagic shock and sepsis tissue injury: comparison with LR, HES, and LR-PTX treatments. ( Kim, HJ; Lee, KH, 2012) |
| "These results indicate that meconium aspiration induces severe inflammation in the lung." | 5.38 | The effects of pentoxifylline on lung inflammation in a rat model of meconium aspiration syndrome. ( Atıcı, A; Helvacı, İ; Muşlu, N; Polat, A; Turhan, AH, 2012) |
| "Pentoxifylline (PTX) is a phosphodiesterase inhibitor that further inhibits multiple cytokine pathways involved in nerve degeneration, apoptosis, and fibrosis." | 5.37 | Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction. ( Albersen, M; Banie, L; De Ridder, D; Fandel, TM; Lin, CS; Lin, G; Lue, TF; Zhang, H, 2011) |
| "Cerebral edema is the most common cause of neurological deterioration and mortality during acute ischemic stroke." | 5.37 | Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats. ( Akhavan, MM; Mojarrad, S; Rashidy-Pour, A; Vakili, A, 2011) |
| "Pentoxifylline and M-1 treatment significantly attenuated colon damage and inflammation in TNBS-colitis (P<0." | 5.37 | The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis. ( Peterson, MR; Peterson, TC; Raoul, JM, 2011) |
| "Pentoxifylline (PTX) has been shown to attenuate neutrophil activation and end-organ injury in shock states such as hemorrhage and sepsis." | 5.35 | Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. ( Coimbra, R; de Campos, T; Deree, J; Loomis, WH; Martins, JO; Putnam, JG; Shenvi, E, 2008) |
| "Compared with the control group, PTX treatment reduced fibrosis scores at d 7 and d 14 (P<0." | 5.35 | Inhibition of tubulointerstitial fibrosis by pentoxifylline is associated with improvement of vascular endothelial growth factor expression. ( Hou, FF; Zheng, FL; Zhou, QG, 2009) |
| "Pentoxifylline has been shown to improve tissue oxygenation and endothelial function and inhibit proinflammatory cytokine production." | 5.35 | Pentoxifylline in ischemia-induced acute kidney injury in rats. ( Martinelli, R; Okumura, AS; Rodrigues, LE, 2009) |
| "Pentoxifylline (PTX) was proved to exert both anti-inflammatory and anti-fibrotic effects, and was used therapeutically in this experimental model to investigate its role alone or with praziquantel (PZQ) in Schistosoma mansoni-infected mice, and to explore its impact on the tissue expression of transforming growth factor-beta1 (TGF-beta1)." | 5.34 | Pharmacodynamics of pentoxifylline and/or praziquantel in murine schistosomiasis mansoni. ( El-Lakkany, N; Nosseir, M, 2007) |
| "Fibrosis is a common pathological feature observed in muscle from patients with Duchenne muscular dystrophy and in mdx diaphragm." | 5.33 | Pentoxifylline fails to attenuate fibrosis in dystrophic (mdx) diaphragm muscle. ( Gosselin, LE; Williams, JE, 2006) |
| "Crescentic glomerulonephritis is a rapidly progressive form of glomerulonephritis, but treatment remains non-specific." | 5.32 | Pentoxifylline suppresses renal tumour necrosis factor-alpha and ameliorates experimental crescentic glomerulonephritis in rats. ( Chen, YM; Chiang, WC; Lan, HY; Lin, SL; Ng, YY; Tsai, TJ, 2004) |
| "Pentoxifylline (PTX) is a derivative of methyl xanthine and has several beneficial effects in sepsis." | 5.31 | The effects of pentoxifylline on bacterial translocation after intestinal obstruction. ( Gokce, O; Gulay, Z; Kocdor, H; Kocdor, MA, 2002) |
| "Pretreatment with allopurinol or pentoxifilline resulted in significantly lower hepatic enzyme elevation than that in controls in the rat liver ischaemia/reperfusion model." | 5.31 | Allopurinol plus pentoxifilline in hepatic ischaemia/reperfusion injury. ( Baykan, A; Erdem, L; Köksal, H; Tok, H; Yildirim, S, 2002) |
| "Pentoxifylline treatment just after shed blood transfusion significantly attenuated this phenomenon." | 5.31 | The effects of pentoxifylline treatment on bacterial translocation after hemorrhagic shock in rats. ( Arpacik, M; Bakici, MZ; Elagöz, S; Köylüoglu, G, 2001) |
| "Pentoxifylline promotes gut ketogenesis following trauma-hemorrhage and resuscitation." | 5.30 | Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shock. ( Chaudry, IH; Wang, P; Wang, W, 1998) |
| "injection inhibited thrombus formation in small mesenteric vessels for more than 12 hours but less than 24 hours." | 5.28 | [Evaluation of the antithrombotic effects of pentoxifylline, acetylsalicylic acid and low molecular weight heparin in the laser model of thrombosis]. ( Bielawiec, M; Breddin, HK; Krupiński, K; Płonowski, A, 1992) |
| "Ten patients with chronic occlusive arteriosclerosis received single oral doses of 100, 200, 400, 800, and 1200 mg pentoxifylline in a single-blind, placebo-controlled study." | 5.06 | Dose-response effects of pentoxifylline on erythrocyte filterability: clinical and animal model studies. ( Ambrus, JL; Anain, JM; Anain, PM; Anain, SM; Brobst, JA; Cobert, BL; Mitchell, P; Savitsky, JP; Stadler, S, 1990) |
| " The goal in this study was to investigate the effect of pentoxifylline on vasospasm in an experimental subarachnoid hemorrhage model." | 4.02 | The effect of pentoxifylline on cerebral vasospasm following experimental subarachnoid hemorrhage. ( Akalan, N; Bahadir, S; Başar, I; Bilginer, B; Hanalioğlu, Ş; Narin, F, 2021) |
| " The aim of this study was to investigate the effects of pentoxifylline (PTX) on the zone of stasis in burns and burn wound healing." | 3.91 | Salvaging the Zone of Stasis in Burns by Pentoxifylline: An Experimental Study in Rats. ( Coruh, A; Deniz, K; Yucel, B, 2019) |
| " We hypothesized that inhibition of neuroinflammation by the PIC synthesis inhibitor, pentoxifylline (PTX) would prevent depression-like behaviors induced by heart failure (HF) post-MI in OVX female rats." | 3.91 | Role of Myocardial Infarction-Induced Neuroinflammation for Depression-Like Behavior and Heart Failure in Ovariectomized Female Rats. ( Ahmad, M; Lagace, D; Leenen, FHH; Najjar, F, 2019) |
| "Our findings demonstrate that pentoxifylline may be promising in preventing small bowel ischemia-reperfusion injury." | 3.88 | Role of pentoxifylline and iloprost in the prevention of ischemia-reperfusion injury in an experimental model of intestine ischemia-reperfusion in rats. ( Abakay, U; Çakmak, E; Genç, HÇ; Göksel, S; Korkmaz, Ö; Kurt, A; Şahin İnan, ZD; Saraç, B; Soylu, S, 2018) |
| "To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR)." | 3.85 | The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats. ( Fagundes, DJ; Monteiro, HP; Oliveira, GF; Oliveira, TRR; Simões, RS; Taha, MO; Tikazawa, EH, 2017) |
| "Our results suggest that the oral administration of pentoxifylline may be an alternative to current therapies for endometriosis." | 3.85 | Oral Administration of Pentoxifylline Reduces Endometriosis-Like Lesions in a Nude Mouse Model. ( Balasch, J; Carmona, F; Castillo, P; González-Foruria, I; Lozano, F; Martínez-Florensa, M; Perelló, M, 2017) |
| "This study was designed to identify the effect of pentoxifylline on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats." | 3.85 | Pentoxifylline attenuates mucosal damage in an experimental model of rat colitis by modulating tissue biomarkers of inflammation, oxidative stress, and fibrosis. ( Arhan, M; Ekinci, Ö; Erdal, H; G Dumlu, Ş; Gül Utku, Ö; Ibiş, M; Karatay, E; Önal, İK; Yilmaz Demirtaş, C, 2017) |
| "After the rats developed neuropathic pain behavior, a single intraperitoneal injection and continuous infusion of pentoxifylline ameliorated paclitaxel-induced mechanical allodynia." | 3.83 | Pentoxifylline Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain. ( Abdi, S; Hwang, SH; Kim, HK; Kim, SH; Lee, SO, 2016) |
| "Data presented showed that pentoxifylline attenuates microcirculatory disturbances at the mesenteric bed with significant minimization of lung inflammation after a double-injury model of hemorrhagic shock and reperfusion followed by sepsis." | 3.81 | Pentoxifylline attenuates leukocyte-endothelial interactions in a two-hit model of shock and sepsis. ( Aikawa, P; Correia, CJ; Cruz, JW; Cruz, RJ; Mauad, T; Nakagawa, NK; Rocha-e-Silva, M; Sannomiya, P; Zhang, H, 2015) |
| "Pentoxifylline directly alleviated hypertension in metabolic syndrome rats, at least in part, via amelioration of low-grade inflammation and inhibition of angiotensin system." | 3.81 | Pentoxifylline alleviates hypertension in metabolic syndrome: effect on low-grade inflammation and angiotensin system. ( Azhar, A; El-Bassossy, HM, 2015) |
| "To investigate the action of pentoxifylline (PTX) and prostaglandin E1 (PGE1) on ischemia and reperfusion of small intestine tissue in rats, using immunohistochemical analysis." | 3.81 | Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small intestine tissue in rats. An immunohistochemical study. ( Assis, PV; Aydos, RD; Brasileiro, JL; Marks, G; Ramalho, RT; Silva, IS; Takita, LC, 2015) |
| "We have previously shown that pentoxifylline (PTX) protects from vascular complications associated with insulin resistance (IR)." | 3.80 | Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance. ( Azhar, A; El-Bassossy, HM, 2014) |
| " Administration of pentoxifylline reduced the collagen density caused by ischemic priapism in groups 3, 4 and 5 compared with group 2." | 3.80 | The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model. ( Atilgan, D; Erdemir, F; Firat, F; Gencten, Y; Kuyucu, YE; Markoc, F; Parlaktas, BS, 2014) |
| "The role of phosphodiesterase inhibitor, pentoxifylline, in the prevention of cyclophosphamide-induced hemorrhagic cystitis was evaluated in a rat model." | 3.79 | Uroprotective effect of pentoxifylline in cyclophosphamide-induced hemorrhagic cystitis in rats. ( Abo-Salem, OM, 2013) |
| "We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor." | 3.77 | Pretreatment with pentoxifylline has antidepressant-like effects in a rat model of acute myocardial infarction. ( Bah, TM; Godbout, R; Kaloustian, S; Rousseau, G, 2011) |
| "To investigate the effects of pentoxifylline, on vascular endothelial growth factor (VEGF)-C and flk-1 expression in the rat endometriosis model." | 3.76 | Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model. ( Creatsas, G; Deliveliotou, A; Gregoriou, O; Lai, J; Perrea, D; Vlachos, A; Vlahos, NF; Zhao, Y, 2010) |
| "Combining the hemodynamic and immune benefits of hypertonic saline with the anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline (HSPTX) as a hemorrhagic shock resuscitation strategy reduces lung injury when compared with the effects of Ringer's lactate (RL)." | 3.76 | A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock. ( Campos, Td; Coimbra, R; Costantini, TW; Deree, J; Martins, JO; Putnam, JG, 2010) |
| "Pentoxifylline (PTX) has been shown to inhibit renal inflammation in a rat model of crescentic glomerulonephritis." | 3.75 | Pentoxifylline inhibits transforming growth factor-beta signaling and renal fibrosis in experimental crescentic glomerulonephritis in rats. ( Chen, YM; Lan, HY; Lan, XR; Ng, YY; Tsai, TJ; Yang, WC, 2009) |
| "Two PDE inhibitors including cilostazol a PDE3 inhibitor (40 and 400 mg/kg), and pentoxifylline (PTX), a PDE 1-5 inhibitor (50 and 500 mg/kg) were used for a period of 7 days to inhibit angiogenesis, inflammation, and fibrosis in a murine model of sponge-induced peritoneal adhesion." | 3.75 | Cilostazol and pentoxifylline decrease angiogenesis, inflammation, and fibrosis in sponge-induced intraperitoneal adhesion in mice. ( Andrade, SP; Campos, PP; Mendes, JB; Rocha, MA, 2009) |
| "We investigated the effects of iloprost and pentoxifylline on skeletal muscle ischemia-reperfusion injury in a rabbit model." | 3.74 | Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model. ( Aksun, M; Bozok, S; Emrecan, B; Gürbüz, A; Ozcan, AV; Saçar, M; Tulukoğlu, E; Yağdi, S, 2008) |
| " This study evaluated the role of pentoxifylline (PTX) and n-acetylcysteine (NAC) in the reduction of ischemia, reperfusion shock and associated intestinal injury." | 3.74 | Effects of pentoxifylline and n-acetylcysteine on injuries caused by ischemia and reperfusion of splanchnic organs in rats. ( Cerqueira, NF; Hussni, CA; Padovani, CR; Sequeira, JL; Yoshida, WB, 2008) |
| "These results indicate pentoxifylline diminishes leukocyte-endothelium interaction, and may have a therapeutic role in preventing ischemia reperfusion injury in microsurgical operations." | 3.74 | In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury. ( Dalcik, H; Iscen, D; Sen, C; Unal, C, 2007) |
| "To study the effects of lung protective ventilation and pentoxifylline (PTX) on acute lung injury (ALI) caused by open chest wound with seawater inundation of the thoracic cavity." | 3.74 | [Experimental treatment of acute lung injury caused by inundation of thoracic cavity by seawater following open chest wound]. ( Ding, XM; Duan, YY; Meng, JG; Peng, CS; Wang, DP; Xue, ZQ, 2007) |
| "Elucidate the mechanisms of induction of delayed diarrhea and determine the effects of the cytokine production inhibitor pentoxifylline (PTX) and thalidomide (TLD) in the experimental model of intestinal mucositis, induced by CPT-11." | 3.74 | Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide. ( Brito, GA; Carvalho, SB; Cunha, FQ; Melo, ML; Ribeiro, RA; Silva, JV; Soares, PM; Soares, RC; Souza, MH; Vale, ML, 2008) |
| " We hypothesized that the anti-inflammatory agent pentoxifylline (PTX) attenuates postresuscitative lung injury through modulation of transcription factors after hemorrhagic shock." | 3.74 | Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock. ( Coimbra, R; de Campos, T; Deree, J; Loomis, WH; Martins, J; Putnam, JG; Wolf, P, 2007) |
| "The neuroprotective effects of pentoxifylline (PTX) against lithium-pilocarpine (Li-Pc)-induced status epilepticus (SE) in young rats are described." | 3.74 | Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats. ( Ahmad, M; Deeb, SA; Moutaery, KA; Tariq, M, 2008) |
| "We examined the effect of pentoxifylline on existing mechanical allodynia, observing glial activation and proinflammatory cytokine expression in the lumbar spinal cord, when given 7 days after L5 spinal nerve transection." | 3.74 | The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy. ( Feng, X; Guan, R; Li, W; Liu, J; Xu, J; Zhang, J; Zhu, J, 2008) |
| "To investigate whether pentoxifylline (PTX) could influence the increased cytokine gene expression in the retina flowing transient ischemia, and if so, whether it acts through the modulation of nuclear factor kappa B (NF-kappaB) activation." | 3.73 | Pentoxifylline decreases up-regulated nuclear factor kappa B activation and cytokine production in the rat retina following transient ischemia. ( Ji, Q; Jia, H; Lv, R; Xu, J; Zhang, L, 2006) |
| "Iloprost and pentoxyfillin reduced renal ischemia-reperfusion injury in rabbit model." | 3.73 | Effects of Iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model. ( Bozok, S; Emrecan, B; Gürbüz, A; Kestelli, M; Küpelioglu, A; Onem, G; Tulukoglu, E; Yagdi, S, 2006) |
| "To evaluate the efficiency of pentoxifylline (PTX), a methyl xanthine derivative, in preventing renal scar formation after the induction of pyelonephritis in an experimental rat model with delayed antimicrobial therapy." | 3.72 | Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis. ( Boleken, ME; Dindar, H; Ertoy, D; Gokcora, IH; Ozsan, M; Yagmurlu, A, 2003) |
| " In the present study, enhancement in the antimetastatic activity of etoposide (ETP) by encapsulation in sterically stabilized liposomes was evaluated in the murine experimental B16F10 melanoma model." | 3.72 | Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice. ( Gude, RP; Nagarsenker, MS; Rao, SG; Sant, VP, 2003) |
| "The influence and relation between pentoxifylline (PTX) dose and time of administration and mortality rate of animals with experimental peritonitis (EP) were studied." | 3.72 | [The influence of pentoxifylline on the course of experimental peritonitis]. ( Czarnecki, P; Markert, R; Modzelewski, B, 2004) |
| "To examine the effect of pentoxifylline (PTX) on cytokine levels, lipid peroxidation, and antioxidant enzymes in a rabbit model of spinal cord ischemia-reperfusion injury induced by aortic occlusion." | 3.71 | Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits. ( Cindaş, A; Delibaş, N; Savaş, C; Savaş, S; Sütçü, R, 2002) |
| " The purpose of this study was to evaluate the ability of pentoxifylline to alter gut cytokine production in a rat model of prolonged acute peritonitis, to determine its effect on survival in such animals, and to determine whether alteration of gut cytokine production was associated with survival." | 3.70 | Effect of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis. ( Alexander, JW; Mao, JX; Nelson, JL; Ogle, CK; Vohs, T, 1999) |
| "The aim of this study was to investigate whether the methylxanthine-derivative pentoxifylline (PTX) affects bacterial clearance of the organism in states of hemorrhage and endotoxemia." | 3.70 | Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia. ( Heller, A; Heller, S; Koch, T; Urbaschek, R; Weber, K, 1999) |
| "The present study extended the previous studies to determine the effects of acute and repeated administration of caffeine, a non-specific phosphodiesterase (PDE) inhibitor and pentoxyfylline, a specific type-4 phosphodiesterase (PDE4) inhibitor on (1) baseline anxiety-like behavior and (2) the response to an acute challenge with diazepam on anxiety-like behavior in the hole-board test." | 3.70 | Effects of acute and repeated dose administration of caffeine and pentoxifylline on diazepam-induced mouse behavior in the hole-board test. ( Campos, AR; Paula, WG; Rao, VS; Santos, FA; Silva, RM, 1999) |
| "To assess the effects of pentoxifylline posttreatment on hemodynamic variables and acute pulmonary injury in the rat intestinal ischemia-reperfusion (I-R) model, using a recently developed method of fluorescent intravital pulmonary videomicroscopy." | 3.69 | Pentoxifylline attenuates pulmonary macromolecular leakage after intestinal ischemia-reperfusion. ( Carter, MB; Garrison, RN; Wead, WB; Wilson, MA, 1995) |
| "The influence of pentoxifylline (PTX) on mortality and some important mediators was studied in a model of cecal perforation with fulminant intra-abdominal sepsis in rats." | 3.69 | Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats. ( Ekstrøm, P; Giercksky, KE; Lundblad, R, 1995) |
| "To investigate the benefit of pentoxifylline in severe experimental pancreatitis." | 3.69 | Failure of pentoxifylline to ameliorate severe acute pancreatitis in the rat: results of a prospective, randomized, controlled study. ( Bassi, DG; Fernández-del Castillo, C; Foitzik, T; Lewandrowski, K; Rattner, DW; Warshaw, AL, 1994) |
| "The aim of this study was to evaluate the effects of two xanthine derivates, pentoxifylline (PTX) and its more metabolically stable analogue, albifylline (HWA 138), on hepatic sinusoidal perfusion and leukocyte endothelial interactions in the liver after hemorrhagic shock." | 3.69 | Influence of pentoxifylline and albifylline on liver microcirculation and leukocyte adhesion after hemorrhagic shock in the rat. ( Bauer, M; Herzog, C; Maier, M; Marzi, I, 1996) |
| " Oral feeding of yellow phosphorus to pigs reproducibly results in fibrosis after 8 weeks of feeding, extensive fibrosis after 12 weeks and cirrhosis after 16 weeks of yellow phosphorus." | 3.69 | Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism. ( Neumeister, M; Peterson, TC, 1996) |
| "To investigate whether pentoxifylline could play a role in attenuation of the hazardous effects of ischemia/reperfusion on corporeal tissue in a rat model of veno-occlusive priapism (VOP)." | 3.69 | Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissue lipid peroxidation in a rat model. ( Evliyaoğlu, Y; Kaya, B; Kayrin, L, 1997) |
| "The aim of this study was to determine the effects of pentoxifylline (Ptx) in reperfusion injury of the small bowel as a leukocyte stabilizer, free radical scavenger, and microcirculatory regulator." | 3.69 | Pentoxifylline inhibits overflow and reduces intestinal reperfusion injury. ( Aras, T; Ataoğlu, O; Bilgehan, A; Cakmak, M; Dindar, H; Ozgüner, F; Savaş, C; Türközkan, N; Yücesan, S, 1997) |
| "The effect of acute pentoxifylline treatment in an experimental model of colitis was assessed using the trinitrobenzene sulphonic acid (TNBS)-induced rat model of colitis." | 3.69 | Effect of acute pentoxifylline treatment in an experimental model of colitis. ( Davey, K; Peterson, TC, 1997) |
| "To compare effects of a single dose of pentoxifylline (PTX), flunixin meglumine (FM), and their combination (FM/PTX) in a model of equine endotoxemia." | 3.69 | Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses. ( Anders, B; Barton, MH; Baskett, A; Moore, JN; Norton, N, 1997) |
| "In this acute, nonresuscitated, canine hemorrhagic shock model, pentoxifylline did not act as a vasodilator, or have any significant effect on HR, cardiac output, oxygen transport, or lactic acidosis." | 3.68 | Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock. ( Amin, D; Benjamin, E; Fischer, E; Iberti, TJ; Jacobs, E; Klapholtz, A; Oropello, JM, 1991) |
| "The beneficial effects of post-insult administration of pentoxifylline, a novel hemorheologic agent experimentally studied in various ischemic diseases, were evaluated in two models of acute renal failure (ARF): direct nephrotoxicity (mercuric chloride 4 mg/kg via femoral vein) and hemoglobinuria (glycerol 10 ml/kg i." | 3.67 | Effects of pentoxifylline in experimental acute renal failure. ( Brunner, LJ; Luke, DR; Vadiei, K, 1989) |
| "The protective efficacy of pentoxiphylline, piracetam, and dihydroergotoxine against abrupt hypoxia was tested in a model of acute reversible respiratory failure, where repeated apnoeic attacks were induced by inhalation in repeated hypoxic exposures was reduced in control as well as in dihydroergotoxine-treated animals, it was increased after pentoxiphylline, and was not changed after piracetam." | 3.67 | Anti-hypoxic potency of cerebroprotective drugs studied in a model of acute reversible respiratory failure. ( Nistiarová, A; Tkácová, R; Tomori, Z, 1989) |
| " The effect of the haemorrheological agent pentoxifylline was investigated in a canine model of acute myocardial infarction, induced by occlusion of the left anterior descending coronary for 6 h." | 3.67 | Pentoxifylline does not reduce infarct size in a canine model of acute myocardial infarction. ( Campbell, CA; Clavenna, CF; Kloner, RA; Wynne, J, 1988) |
| "Among the microvascular complications, diabetic nephropathy is the most frequent cause of end-stage renal disease." | 2.44 | Efficacy of pentoxifylline in the management of microalbuminuria in patients with diabetes. ( Guerrero-Romero, F; Rodríguez-Morán, M, 2008) |
| "Pentoxifylline has been used extensively to improve microcirculation, particularly in peripheral vascular disease." | 2.38 | "Stiff red cell syndrome". A review of the treatment of sickle cell disease with pentoxifylline. ( Ambrus, JL; Conway, J; Meky, NN; Reddington, TM, 1993) |
| "Pentoxifylline (Trental) is a well-known vasoactive drug with proven clinical efficacy in various circulatory disorders." | 2.38 | The effect of pentoxifylline in septic shock--new pharmacologic aspects of an established drug. ( Schade, UF; Schönharting, MM, 1989) |
| "Pentoxifylline (PTXF) is a xanthine derivative that can modulate the nuclear factor kappa B (NF-κB) signaling and probably affect the Treg proportion in TILs." | 1.72 | Decrease of Tumor-infiltrating Regulatory T Cells Using Pentoxifylline: An Ex Vivo Analysis in Triple-negative Breast Cancer Mouse Model. ( Falak, R; Ghanavatinejad, A; Kazemi, MH; Khorrami, S; Momeni-Varposhti, Z; Sadeghi, B; Shokrollahi Barough, M, 2022) |
| "Cardiac inflammation was interrogated via expression levels of TNF α, interleukins 6 and 10, phosphorylated STAT4 and lipoxygenases 12 and 12/15." | 1.62 | Lisofylline mitigates cardiac inflammation in a mouse model of obesity through improving insulin secretion and activating cardiac AMPK signaling pathway. ( Abdelzaher, LA; Ali, M; Bakr, MH; Desai, AA; Mali, V; Radwan, E; Sayed, SA, 2021) |
| "Animals without steatosis (ie NAFLD) at week 16 were excluded from the data analysis." | 1.62 | The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis. ( Andersen, M; Buelund, LE; Ipsen, DH; Latta, M; Lintrup, K; Lykkesfeldt, J; Skaarup, R; Skat-Rørdam, J; Svenningsen, M; Tveden-Nyborg, P, 2021) |
| "Pentoxifylline (PTX) has been shown to competitively inhibit the family 18 chitinases in fungi, which may be an new antifungal therapy." | 1.62 | Therapeutic effects of pentoxifylline on invasive pulmonary aspergillosis in immunosuppressed mice. ( Feng, C; Li, C; Zhang, J; Zhang, M; Zhang, S; Zhou, J, 2021) |
| "Pentoxifylline (PTX) is a phosphodiesterase inhibitor that increases cyclic adenosine monophosphate levels, which in turn activate protein kinase, leading to a reduction in the synthesis of proinflammatory cytokines to ultimately influence the renin-angiotensin system (RAS) in vitro by inhibiting angiotensin 1 receptor (AT1R) expression." | 1.56 | Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19. ( Chávez-Alderete, J; Loza-Mejía, MA; Maldonado, V, 2020) |
| "Systemic arterial hypertension is a public health problem associated with an increased risk of cardiovascular disease." | 1.56 | TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure. ( Amaral, JH; Bonacio, GF; Dellalibera-Joviliano, R; Franca, SC; Garcia, VT; Mattos, BR; Rizzi, E; Tanus-Santos, JE; Vitorino, TR, 2020) |
| "Post-traumatic stress disorder (PTSD) is characterized by a disordered stress response and associated with increased cardiovascular disease risk." | 1.51 | Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α. ( Beltz, TG; Felder, RB; Guo, F; Johnson, AK; Wei, SG; Xue, B; Yu, Y, 2019) |
| "A malondialdehyde (MDA) assay was performed to evaluate oxidative stress, and histochemical analyses (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling [TUNEL], Bcl-2 and Bax) were conducted to evaluate kidney apoptosis." | 1.51 | Hypertonic saline and pentoxifylline enhance survival, reducing apoptosis and oxidative stress in a rat model of strangulated closed loop small bowel obstruction. ( Cayuela, NC; Goes, MA; Koike, MK; Rasslan, R; Rasslan, S; Scapini, G; Souza Montero, EF; Utiyama, EM, 2019) |
| "Treatment with pentoxifylline significantly recovered the cerebral ischemia reperfusion‑induced neurological deficit score and cerebral infarct volume in rats." | 1.48 | Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway. ( Dong, J; Xie, W; Yuan, X, 2018) |
| "Pentoxifylline (PTX) is a potent antioxidant, which has an important role in prevention of cognitive dysfunctions." | 1.48 | Pentoxifylline prevents post-traumatic stress disorder induced memory impairment. ( Ahmed, M; Alzoubi, KH; Khabour, OF, 2018) |
| "The effective treatments of endotoxemia are necessary to prevent high mortality rates." | 1.43 | The comparative efficacy of tyloxapol versus pentoxifylline against induced acute phase response in an ovine experimental endotoxemia model. ( Badiei, K; Chalmeh, A; Heidari, SM; Nazifi, S; Pourjafar, M; Rahmani Shahraki, A; Zamiri, MJ, 2016) |
| "Pentoxifylline has anti‑inflammatory, anti-apoptotic, anti-thrombotic and anti-proliferative properties." | 1.43 | Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure. ( Azevedo, P; Fernandes, AA; Lustosa, B; Minicucci, M; Oliveira, F; Paiva, S; Polegato, B; Roscani, M; Santos, P; Zornoff, L, 2016) |
| "Pentoxifylline (PTX) is a methylxanthine derivative clinically proven to improve perfusion in the peripheral microcirculation and has been shown to have neuroprotective effects in brain trauma and global cerebral ischemia in experimental animal models." | 1.43 | Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage. ( Aslan, M; Demır, N; Dilmac, S; Dogan, O; Goksu, E; Kirac, E; Konuk, E; Tanrıover, G; Ulker, P, 2016) |
| "Oral mucositis is a frequent early side effect of radio(chemo)therapy of head-and-neck malignancies." | 1.42 | Modulation of radiation-induced oral mucositis by pentoxifylline: preclinical studies. ( Bozsaky, E; Dörr, W; Gruber, S; Haagen, J; Habelt, B; Puttrich, M; Schmidt, M; Wolfram, K, 2015) |
| "Pentoxifylline has a significant efficacy for increasing serum levels of sexual hormones." | 1.42 | Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats. ( Ghanbari, A; Mahmoodi, M; Moradi, M; Raoofi, A, 2015) |
| "Anti-Thy1 glomerulonephritis is a rat nephritis model closely simulating human mesangial proliferative glomerulonephritis." | 1.42 | Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling. ( Chen, YM; Chiang, WC; Lai, CF; Lin, SL; Wu, KD; Yang, Y, 2015) |
| "Pentoxifylline (PTX) is a potent antioxidant." | 1.42 | An evaluation of the effect of pentoxifylline on blood pressure and myocardial oxidative status following intake of western diet. ( Al-Taleb, Z; Alzoubi, KH; Mayyas, F, 2015) |
| " Additionally, the effects of chronic administration of the tricyclic antidepressant imipramine and the anti-TNF-α pentoxyphylline were investigated." | 1.40 | Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. ( Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK, 2014) |
| "The results show that chronic sleep deprivation impaired short- and long-term memories, which was prevented by chronic treatment with PTX." | 1.39 | Evaluation of the effect of pentoxifylline on sleep-deprivation induced memory impairment. ( Al-Azzam, SI; Alzoubi, KH; Khabour, OF; Mhaidat, NM; Tashtoush, NH, 2013) |
| "Pentoxifylline had a significant protective effect on severely ischemic bowel when administered during reperfusion at a dosage of 10 mg/kg." | 1.39 | Pentoxifylline protects the small intestine after severe ischemia and reperfusion. ( Cejalvo Lapeña, D; Lloris Carsi, JM; Toledo Pereyra, LH; Toledo, AH; Zaragoza Fernandez, C, 2013) |
| "Concomitantly to AIA, mice presented alveolar bone loss, and recruitment of osteoclasts and neutrophils to periodontal tissues." | 1.39 | Preventive and therapeutic anti-TNF-α therapy with pentoxifylline decreases arthritis and the associated periodontal co-morbidity in mice. ( Bessoni, RL; Costa, VV; Queiroz-Junior, CM; Silva, TA; Souza, DG; Teixeira, MM, 2013) |
| "Pretreatment with pentoxifylline markedly downregulated TNF-α at both the mRNA and protein levels, whereas infliximab pretreatment did not affect the expression of TNF-α induced by I/R." | 1.39 | Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury. ( Liu, HL; Tan, SW; Tao, J; Wu, B; Yang, Q; Zhan, YS; Zheng, FP, 2013) |
| " Damage was reduced with the use of pentoxifylline, however further studies are needed to evaluate the dose-response of the drug." | 1.39 | A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury. ( Almeida, JC; Cruz, RH; Lourenço, E; Oliveira-Júnior, IS; Ramallo, BT; Silva, PY; Taha, MO, 2013) |
| "Pentoxifylline (PTX) is a derivative of methylxanthine and is used in peripheral vascular and cerebrovascular diseases for its effect on the regulation of blood circulation." | 1.38 | Effect of pentoxifylline on histopathological changes in steroid-induced osteonecrosis of femoral head: experimental study in chicken. ( Aktas, M; Erken, HY; Ofluoglu, O; Topal, C; Yildiz, M, 2012) |
| "The mean lung injury score was 1." | 1.38 | The effectiveness of hypertonic saline and pentoxifylline (HTS-PTX) resuscitation in haemorrhagic shock and sepsis tissue injury: comparison with LR, HES, and LR-PTX treatments. ( Kim, HJ; Lee, KH, 2012) |
| "These results indicate that meconium aspiration induces severe inflammation in the lung." | 1.38 | The effects of pentoxifylline on lung inflammation in a rat model of meconium aspiration syndrome. ( Atıcı, A; Helvacı, İ; Muşlu, N; Polat, A; Turhan, AH, 2012) |
| "Pentoxifylline (PTX) is a phosphodiesterase inhibitor that further inhibits multiple cytokine pathways involved in nerve degeneration, apoptosis, and fibrosis." | 1.37 | Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction. ( Albersen, M; Banie, L; De Ridder, D; Fandel, TM; Lin, CS; Lin, G; Lue, TF; Zhang, H, 2011) |
| "Cerebral edema is the most common cause of neurological deterioration and mortality during acute ischemic stroke." | 1.37 | Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats. ( Akhavan, MM; Mojarrad, S; Rashidy-Pour, A; Vakili, A, 2011) |
| "Pentoxifylline and M-1 treatment significantly attenuated colon damage and inflammation in TNBS-colitis (P<0." | 1.37 | The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis. ( Peterson, MR; Peterson, TC; Raoul, JM, 2011) |
| "Pentoxifylline (PTX) is an anti-inflmmatory and anti-oxidant agent." | 1.37 | Protective effect of pentoxyfilline in renal toxicity after methotrexate administration. ( Asl, NA; Asvadi, A; Asvadi, I; Hajipour, B; Khodadadi, A; Roshangar, L, 2011) |
| "Colonic ischemia was established in all the groups." | 1.37 | Effect of pentoxifylline and vinpocetine on the healing of ischemic colon anastomosis: an experimental study. ( Altınlı, E; Eroğlu, E; Güneş, P; Köksal, N; Onur, E; Senger, S; Sümer, A, 2011) |
| "Pentoxifylline (PTX) has been shown to attenuate neutrophil activation and end-organ injury in shock states such as hemorrhage and sepsis." | 1.35 | Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis. ( Coimbra, R; de Campos, T; Deree, J; Loomis, WH; Martins, JO; Putnam, JG; Shenvi, E, 2008) |
| "Compared with the control group, PTX treatment reduced fibrosis scores at d 7 and d 14 (P<0." | 1.35 | Inhibition of tubulointerstitial fibrosis by pentoxifylline is associated with improvement of vascular endothelial growth factor expression. ( Hou, FF; Zheng, FL; Zhou, QG, 2009) |
| "Pentoxifylline has been shown to improve tissue oxygenation and endothelial function and inhibit proinflammatory cytokine production." | 1.35 | Pentoxifylline in ischemia-induced acute kidney injury in rats. ( Martinelli, R; Okumura, AS; Rodrigues, LE, 2009) |
| " Since theophylline has two modes of action, in the present study we tested whether chronic administration of pentoxifylline, a non-selective phosphodiesterase inhibitor, rolipram, a phosphodiesterase-4 specific inhibitor, and 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), an adenosine A1 receptor antagonist, would induce recovery similar to that induced by theophylline in male Sprague-Dawley rats following a left C2 spinal cord lesion." | 1.35 | Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats. ( Goshgarian, HG; Kajana, S, 2008) |
| "Pentoxifylline (PTX) was proved to exert both anti-inflammatory and anti-fibrotic effects, and was used therapeutically in this experimental model to investigate its role alone or with praziquantel (PZQ) in Schistosoma mansoni-infected mice, and to explore its impact on the tissue expression of transforming growth factor-beta1 (TGF-beta1)." | 1.34 | Pharmacodynamics of pentoxifylline and/or praziquantel in murine schistosomiasis mansoni. ( El-Lakkany, N; Nosseir, M, 2007) |
| "Oral mucositis is a frequent side-effect of cancer therapy." | 1.33 | Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters. ( Augusto, RF; Brito, GA; Cunha, FQ; Falcão, BA; Leitão, BT; Lima, V; Rebouças, CG; Ribeiro, RA; Souza, ML, 2005) |
| "Myocardial infarction was produced in anesthetized rats by a 40-minute occlusion of the left anterior descending coronary artery followed by 72 hours of reperfusion." | 1.33 | Apoptosis detected in the amygdala following myocardial infarction in the rat. ( Boucher, M; Godbout, R; Kaloustian, S; Nim, S; Rousseau, G; Wann, BP, 2006) |
| "Duchenne muscular dystrophy is a frequent muscular disorder caused by mutations in the gene encoding dystrophin, a cytoskeletal protein that contributes to the stabilization of muscle fiber membrane during muscle activity." | 1.33 | Green tea extract and its major polyphenol (-)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy. ( Buetler, TM; Dorchies, OM; Kucera, P; Ruegg, UT; Vuadens, O; Wagner, S; Waldhauser, K, 2006) |
| "We postulated that PTX treatment in acute endotoxemia downregulates the inflammatory response and may decrease lung injury." | 1.33 | LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression. ( Coimbra, R; Hoyt, DB; Loomis, W; Melbostad, H; Porcides, RD; Tobar, M; Wolf, P, 2006) |
| "Fibrosis is a common pathological feature observed in muscle from patients with Duchenne muscular dystrophy and in mdx diaphragm." | 1.33 | Pentoxifylline fails to attenuate fibrosis in dystrophic (mdx) diaphragm muscle. ( Gosselin, LE; Williams, JE, 2006) |
| "Pentoxifylline has several functions including downregulation of TNF-alpha and endothelia-dependent vascular relaxation." | 1.33 | Pentoxifylline protects against endotoxin-induced acute renal failure in mice. ( Basava, V; Falk, S; Reznikov, L; Schrier, R; Wang, W; Zolty, E, 2006) |
| "Pentoxifylline (PTX) has been reported to inhibit TNF-alpha production and prevent several types of acute renal failure." | 1.32 | Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits. ( Choi, TR; Jung, JS; Kim, JH; Kim, YK; Kwon, CH; Woo, JS, 2003) |
| "Crescentic glomerulonephritis is a rapidly progressive form of glomerulonephritis, but treatment remains non-specific." | 1.32 | Pentoxifylline suppresses renal tumour necrosis factor-alpha and ameliorates experimental crescentic glomerulonephritis in rats. ( Chen, YM; Chiang, WC; Lan, HY; Lin, SL; Ng, YY; Tsai, TJ, 2004) |
| "Diffuse peritonitis was elicited by means of cecal ligation and puncture (CLP) in 45 adult Wistar rats." | 1.32 | Pentoxyphilline as a cyclooxygenase (cox-2) inhibitor in experimental sepsis. ( Janiak, A; Modzelewski, B, 2004) |
| " Adult male Wistar albino rats were randomly divided into three groups: normal control (the N group), diabetic nephropathy (the DN group), and diabetic nephropathy treated with pentoxifylline at the dosage of 20 mg x kg(-1) x d(-1), intraperitoneally (the group DNP)." | 1.32 | The effects of pentoxifylline on diabetic renal changes in streptozotocin-induced diabetes mellitus. ( Canoz, O; Dusunsel, R; Gunduz, Z; Per, H; Poyrazoglu, MH; Saraymen, R; Tez, C, 2004) |
| "A fatal guinea pig model of pneumococcal pneumonia was developed in order to evaluate the efficacy of amoxicillin combined with either pentoxifylline or dexamethasone." | 1.31 | Effect of dexamethasone and pentoxifylline in combination with amoxicillin in the treatment of penicillin-insensitive pneumococcal pneumonia in guinea pigs. ( García-Calvo, G; García-Olmos, M; Nieto, E; Parra, A; Ponte, C; Soriano, F, 2002) |
| "Pentoxifylline (PTX) is a derivative of methyl xanthine and has several beneficial effects in sepsis." | 1.31 | The effects of pentoxifylline on bacterial translocation after intestinal obstruction. ( Gokce, O; Gulay, Z; Kocdor, H; Kocdor, MA, 2002) |
| "Pretreatment with allopurinol or pentoxifilline resulted in significantly lower hepatic enzyme elevation than that in controls in the rat liver ischaemia/reperfusion model." | 1.31 | Allopurinol plus pentoxifilline in hepatic ischaemia/reperfusion injury. ( Baykan, A; Erdem, L; Köksal, H; Tok, H; Yildirim, S, 2002) |
| "Pentoxifylline is a phosphodiesterase inhibitor, known to suppress tumour necrosis factor-alpha production and improve cardiopulmonary parameters and survival in animal models of sepsis." | 1.31 | Pentoxifylline fails to improve organ dysfunction and survival when used in the resuscitation of a porcine model of haemorrhage and abdominal sepsis. ( Brown, D; Kenward, CE; Parker, SJ; Watkins, PE, 2000) |
| "The pathogenesis of acute renal failure may involve, among other causes, ischemia, vascular congestion, arachidonic acid pathways, and reactive oxygen metabolites." | 1.31 | Effect of vitamin E and pentoxifylline on glycerol-induced acute renal failure. ( Akpolat, I; Akpolat, T; Bedir, A; Coşar, AM; Kandemir, B; Oztürk, H; Sarikaya, S, 2000) |
| "Pentoxifylline has been shown to exhibit anti-metastatic activity by inhibiting homing of B16F10 melanoma cells in the murine experimental metastasis model." | 1.31 | Enhancement of anti-metastatic activity of pentoxifylline by encapsulation in conventional liposomes and sterically stabilized liposomes in murine experimental B16F10 melanoma model. ( Gude, RP; Nagarsenker, MS; Rao, SG; Sant, VP, 2000) |
| "Pentoxifylline (PTX) has antiinflammatory effects and may limit endothelial dysfunction during ischemia/reperfusion." | 1.31 | Pentoxifylline reduces coronary leukocyte accumulation early in reperfusion after cold ischemia. ( Copeland, JG; Gale, SC; Gorman, GD; Hokama, JY; McDonagh, PF; Ritter, LS, 2001) |
| "Pentoxifylline treatment just after shed blood transfusion significantly attenuated this phenomenon." | 1.31 | The effects of pentoxifylline treatment on bacterial translocation after hemorrhagic shock in rats. ( Arpacik, M; Bakici, MZ; Elagöz, S; Köylüoglu, G, 2001) |
| "Unilateral testicular torsion caused decrease in bilateral testicular blood flow." | 1.31 | Pentoxifylline improves blood flow to both testes in testicular torsion. ( Aras, T; Dindar, H; Savaş, C; Yücesan, S, 2002) |
| "Pentoxifylline promotes gut ketogenesis following trauma-hemorrhage and resuscitation." | 1.30 | Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shock. ( Chaudry, IH; Wang, P; Wang, W, 1998) |
| "Pentoxifylline (PTX) is a phosphodiesterase inhibitor used in the treatment of peripheral vascular disease, and this agent can suppress inflammatory vascular damage." | 1.30 | Pentoxifylline inhibits neointimal formation and stimulates constrictive vascular remodeling after arterial injury. ( Andersen, CB; Hansen, PR; Holm, AM; Ledet, T; Qi, JH; Rasmussen, LM, 1999) |
| "Pentoxifylline treatment reduced lung neutrophil sequestration and IL-1 beta mRNA levels and increased cell recruitment in the peritoneum." | 1.29 | Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis. ( Cheadle, WG; Hadjiminas, DJ; McMasters, KM; Robertson, SE, 1994) |
| "In this study we treated groups of MAIDS-infected mice with combinations of pentoxifylline, an agent which increases cAMP and inhibits phosphodiesterases, and sodium meclofenamic acid, a PgE2 inhibitor." | 1.29 | Pentoxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine model of AIDS. ( Ambrus, JL; Butsch, J; Chadha, KC; Mathur, N; Munschauer, F; Nakeeb, S; Satchidanand, SK; Stadler, I; Toumbis, C; Vladutiu, A, 1994) |
| "Pentoxifylline-treated animals had lower levels of lysozyme (p < ." | 1.29 | Effects of pentoxifylline on in vivo leukocyte function and clearance of group B streptococci from preterm rabbit lungs. ( Aeberhard, EE; Gilliam, MB; Mah, MP; Sherman, MP, 1993) |
| "injection inhibited thrombus formation in small mesenteric vessels for more than 12 hours but less than 24 hours." | 1.28 | [Evaluation of the antithrombotic effects of pentoxifylline, acetylsalicylic acid and low molecular weight heparin in the laser model of thrombosis]. ( Bielawiec, M; Breddin, HK; Krupiński, K; Płonowski, A, 1992) |
| " A total of 48 rats were orally dosed with CSA 25 mg/kg for 10 days with either PTX 45 mg/kg i." | 1.28 | Prevention of cyclosporine-induced nephrotoxicity with pentoxifylline. ( Brunner, LJ; Iyer, LV; Luke, DR; Vadiei, K, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (3.82) | 18.7374 |
| 1990's | 53 (20.23) | 18.2507 |
| 2000's | 94 (35.88) | 29.6817 |
| 2010's | 88 (33.59) | 24.3611 |
| 2020's | 17 (6.49) | 2.80 |
| Authors | Studies |
|---|---|
| Cottam, HB | 1 |
| Shih, H | 1 |
| Tehrani, LR | 1 |
| Wasson, DB | 1 |
| Carson, DA | 1 |
| Fujita, M | 1 |
| Seki, T | 1 |
| Ikeda, N | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 5 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Malekzadeh, M | 1 |
| Takzaree, N | 1 |
| Toolee, H | 1 |
| Kazemzadeh, S | 1 |
| Khanmohammadi, N | 1 |
| Solhjoo, S | 1 |
| Sadeghiani, G | 1 |
| Shabani, M | 1 |
| Rastegar, T | 1 |
| Fulas, OA | 1 |
| Laferrière, A | 2 |
| Coderre, TJ | 2 |
| Kazemi, MH | 1 |
| Shokrollahi Barough, M | 1 |
| Ghanavatinejad, A | 1 |
| Momeni-Varposhti, Z | 1 |
| Khorrami, S | 1 |
| Sadeghi, B | 1 |
| Falak, R | 1 |
| Silva Grijó Farani, P | 1 |
| Iandra da Silva Ferreira, B | 1 |
| Begum, K | 1 |
| Vilar-Pereira, G | 1 |
| Pereira, IR | 1 |
| Fernández-Figueroa, EA | 1 |
| Cardenas-Ovando, RA | 1 |
| Almeida, IC | 1 |
| Roy, S | 2 |
| Lannes-Vieira, J | 1 |
| Moreira, OC | 1 |
| Finato, AC | 1 |
| Almeida, DF | 1 |
| Dos Santos, AR | 1 |
| Nascimento, DC | 1 |
| Cavalcante, RS | 1 |
| Mendes, RP | 1 |
| Soares, CT | 1 |
| Paniago, AMM | 1 |
| Venturini, J | 1 |
| Wang, XF | 1 |
| Li, JD | 1 |
| Huo, YL | 1 |
| Zhang, YP | 1 |
| Fang, ZQ | 1 |
| Wang, HP | 1 |
| Peng, W | 1 |
| Johnson, AK | 2 |
| Xue, B | 3 |
| Matboli, M | 1 |
| Habib, EK | 1 |
| Hussein Mohamed, R | 1 |
| Mahran, NA | 1 |
| Seleem, HS | 1 |
| Nosseir, N | 1 |
| Hasanin, AH | 1 |
| Bahadir, S | 1 |
| Narin, F | 1 |
| Başar, I | 1 |
| Hanalioğlu, Ş | 1 |
| Bilginer, B | 1 |
| Akalan, N | 1 |
| Seo, MH | 1 |
| Myoung, H | 1 |
| Lee, JH | 1 |
| Yang, HC | 1 |
| Woo, KM | 1 |
| Lee, SK | 1 |
| Kim, SM | 1 |
| Maldonado, V | 1 |
| Loza-Mejía, MA | 1 |
| Chávez-Alderete, J | 1 |
| Mattos, BR | 1 |
| Bonacio, GF | 1 |
| Vitorino, TR | 1 |
| Garcia, VT | 1 |
| Amaral, JH | 1 |
| Dellalibera-Joviliano, R | 1 |
| Franca, SC | 1 |
| Tanus-Santos, JE | 1 |
| Rizzi, E | 1 |
| Ali, M | 1 |
| Bakr, MH | 1 |
| Abdelzaher, LA | 1 |
| Sayed, SA | 1 |
| Mali, V | 1 |
| Desai, AA | 1 |
| Radwan, E | 1 |
| Ipsen, DH | 1 |
| Skat-Rørdam, J | 1 |
| Svenningsen, M | 1 |
| Andersen, M | 1 |
| Latta, M | 1 |
| Buelund, LE | 1 |
| Lintrup, K | 1 |
| Skaarup, R | 1 |
| Lykkesfeldt, J | 1 |
| Tveden-Nyborg, P | 1 |
| Feng, C | 1 |
| Zhang, M | 2 |
| Zhang, S | 1 |
| Zhang, J | 4 |
| Li, C | 1 |
| Zhou, J | 1 |
| El-Sadek, HM | 1 |
| Al-Shorbagy, MY | 1 |
| Awny, MM | 1 |
| Abdallah, DM | 1 |
| El-Abhar, HS | 1 |
| Zheng, XF | 1 |
| Chen, DD | 1 |
| Zhu, XL | 1 |
| Le Grange, JM | 1 |
| Zhou, LQ | 1 |
| Zhang, JN | 1 |
| Choi, B | 2 |
| Sayeed, HM | 1 |
| Islam, SMS | 1 |
| Sohn, S | 2 |
| Oliveira, TRR | 2 |
| Oliveira, GF | 2 |
| Simões, RS | 2 |
| Tikazawa, EH | 2 |
| Monteiro, HP | 2 |
| Fagundes, DJ | 2 |
| Taha, MO | 3 |
| Plotnikov, MB | 1 |
| Shamanaev, AY | 1 |
| Aliev, OI | 1 |
| Sidekhmenova, AV | 1 |
| Anishchenko, AM | 1 |
| Arkhipov, AM | 1 |
| Dong, J | 1 |
| Yuan, X | 1 |
| Xie, W | 2 |
| Feitosa, SM | 1 |
| Mohamed, DI | 1 |
| Nabih, ES | 1 |
| El-Waseef, DAA | 1 |
| El-Kharashi, OA | 1 |
| Abd El Samad, AA | 1 |
| Ionică, FE | 1 |
| Mogoantă, L | 1 |
| Negreş, S | 1 |
| Bejenaru, LE | 1 |
| Cristea, OM | 1 |
| Badea, O | 1 |
| Bejenaru, C | 1 |
| Alzoubi, KH | 3 |
| Khabour, OF | 2 |
| Ahmed, M | 1 |
| Elseweidy, MM | 1 |
| Mohamed, HE | 1 |
| Elrashidy, RA | 1 |
| Atteia, HH | 1 |
| Elnagar, GM | 1 |
| Ozturk, H | 3 |
| Cetinkaya, A | 1 |
| Firat, TS | 1 |
| Tekce, BK | 1 |
| Duzcu, SE | 1 |
| Eğin, S | 1 |
| İlhan, M | 1 |
| Bademler, S | 1 |
| Gökçek, B | 1 |
| Hot, S | 1 |
| Ekmekçi, H | 1 |
| Ekmekçi, ÖB | 1 |
| Tanrıverdi, G | 1 |
| Dağıstanlı, FK | 1 |
| Kamalı, G | 1 |
| Kamalı, S | 1 |
| Güloğlu, R | 1 |
| El-Anwar, MW | 1 |
| Abdelmonem, S | 1 |
| Nada, E | 1 |
| Galhoom, D | 1 |
| Abdelsameea, AA | 1 |
| Abakay, U | 1 |
| Soylu, S | 1 |
| Göksel, S | 1 |
| Saraç, B | 1 |
| Şahin İnan, ZD | 1 |
| Çakmak, E | 1 |
| Korkmaz, Ö | 1 |
| Kurt, A | 1 |
| Genç, HÇ | 1 |
| Yucel, B | 1 |
| Coruh, A | 1 |
| Deniz, K | 1 |
| Kheradmand, N | 1 |
| Kamkar, R | 1 |
| Moshajjari, M | 1 |
| Baazm, M | 1 |
| Yu, Y | 1 |
| Wei, SG | 1 |
| Beltz, TG | 1 |
| Guo, F | 1 |
| Felder, RB | 2 |
| Scapini, G | 1 |
| Rasslan, R | 1 |
| Cayuela, NC | 1 |
| Goes, MA | 1 |
| Koike, MK | 1 |
| Utiyama, EM | 1 |
| Souza Montero, EF | 1 |
| Rasslan, S | 1 |
| Yang, F | 1 |
| Chen, E | 1 |
| Yang, Y | 2 |
| Han, F | 1 |
| Han, S | 1 |
| Wu, G | 1 |
| Han, J | 1 |
| Su, L | 1 |
| Hu, D | 1 |
| Najjar, F | 1 |
| Ahmad, M | 2 |
| Lagace, D | 1 |
| Leenen, FHH | 1 |
| Le Campion, ER | 1 |
| Jukemura, J | 1 |
| Coelho, AM | 2 |
| Patzina, R | 1 |
| Carneiro D'Albuquerque, LA | 1 |
| Tashtoush, NH | 1 |
| Al-Azzam, SI | 1 |
| Mhaidat, NM | 1 |
| Dilek, M | 1 |
| Kumral, A | 2 |
| Okyay, E | 1 |
| Ozbal, S | 1 |
| Tugyan, K | 1 |
| Tuzun, F | 1 |
| Sever, AH | 1 |
| Yilmaz, O | 3 |
| Duman, N | 2 |
| Ozkan, H | 2 |
| Abo-Salem, OM | 1 |
| Lloris Carsi, JM | 1 |
| Cejalvo Lapeña, D | 1 |
| Toledo, AH | 1 |
| Zaragoza Fernandez, C | 1 |
| Toledo Pereyra, LH | 1 |
| Ragavendran, JV | 1 |
| Khorashadi, M | 1 |
| Queiroz-Junior, CM | 1 |
| Bessoni, RL | 1 |
| Costa, VV | 1 |
| Souza, DG | 1 |
| Teixeira, MM | 1 |
| Silva, TA | 1 |
| Yang, Q | 1 |
| Zheng, FP | 1 |
| Zhan, YS | 1 |
| Tao, J | 1 |
| Tan, SW | 1 |
| Liu, HL | 1 |
| Wu, B | 1 |
| Kalay, S | 2 |
| Oztekin, O | 1 |
| Tezel, G | 1 |
| Aldemir, H | 2 |
| Sahin, E | 1 |
| Koksoy, S | 1 |
| Akcakus, M | 2 |
| Oygur, N | 2 |
| Islek, A | 1 |
| Ozturk, A | 1 |
| Kalay, Z | 1 |
| Elpek, O | 1 |
| Anower, AK | 1 |
| Shim, JA | 1 |
| Kwon, HJ | 1 |
| Brasileiro, JL | 2 |
| Inoye, CM | 1 |
| Aydos, RD | 2 |
| Silva, IS | 2 |
| Falcão, GR | 1 |
| Marks, G | 2 |
| Pereira, DM | 1 |
| Hamidian Jahromi, A | 1 |
| Youssef, AM | 1 |
| Casanova, J | 1 |
| Bataller, R | 1 |
| Azhar, A | 2 |
| El-Bassossy, HM | 2 |
| Erdemir, F | 1 |
| Firat, F | 1 |
| Markoc, F | 1 |
| Atilgan, D | 1 |
| Parlaktas, BS | 1 |
| Kuyucu, YE | 1 |
| Gencten, Y | 1 |
| Nakagawa, NK | 1 |
| Cruz, RJ | 1 |
| Aikawa, P | 1 |
| Correia, CJ | 1 |
| Cruz, JW | 1 |
| Mauad, T | 1 |
| Zhang, H | 2 |
| Rocha-e-Silva, M | 1 |
| Sannomiya, P | 2 |
| Santarem, AA | 1 |
| Greggianin, GF | 1 |
| Debastiani, RG | 1 |
| Ribeiro, JB | 1 |
| Polli, DA | 1 |
| Sampaio, RN | 1 |
| Elgarf, AS | 1 |
| Aboul-Fotouh, S | 1 |
| Abd-Alkhalek, HA | 1 |
| El Tabbal, M | 1 |
| Hassan, AN | 1 |
| Kassim, SK | 1 |
| Hammouda, GA | 1 |
| Farrag, KA | 1 |
| Abdel-tawab, AM | 1 |
| Gruber, S | 3 |
| Schmidt, M | 3 |
| Bozsaky, E | 3 |
| Wolfram, K | 2 |
| Haagen, J | 2 |
| Habelt, B | 2 |
| Puttrich, M | 2 |
| Dörr, W | 3 |
| Reyhan, E | 2 |
| Irkorucu, O | 2 |
| Surmelioglu, A | 2 |
| Ozkara, S | 2 |
| Deger, KC | 2 |
| Aziret, M | 2 |
| Erdem, H | 2 |
| Cetinkunar, S | 2 |
| Demirturk, P | 1 |
| Sehirli, AO | 1 |
| Shirazi, M | 2 |
| Soltani, MR | 1 |
| Jahanabadi, Z | 1 |
| Abdollahifar, MA | 1 |
| Tanideh, N | 1 |
| Noorafshan, A | 1 |
| Das, K | 1 |
| Sozen, S | 1 |
| Bali, I | 1 |
| Ramalho, RT | 1 |
| Takita, LC | 1 |
| Assis, PV | 1 |
| Moura, JF | 1 |
| Mota, JM | 1 |
| Leite, CA | 1 |
| Wong, DV | 1 |
| Bezerra, NP | 1 |
| Brito, GA | 4 |
| Lima, V | 2 |
| Cunha, FQ | 4 |
| Ribeiro, RA | 4 |
| Moradi, M | 1 |
| Mahmoodi, M | 1 |
| Raoofi, A | 1 |
| Ghanbari, A | 1 |
| Rocha-Santos, V | 1 |
| Figueira, ER | 1 |
| Rocha-Filho, JA | 1 |
| Pinheiro, RS | 1 |
| Bacchella, T | 1 |
| Machado, MC | 1 |
| D'Albuquerque, LA | 1 |
| Chen, YM | 4 |
| Chiang, WC | 2 |
| Lai, CF | 1 |
| Wu, KD | 2 |
| Lin, SL | 2 |
| Hamedinger, D | 1 |
| Armagan, I | 1 |
| Bayram, D | 1 |
| Candan, IA | 1 |
| Yigit, A | 1 |
| Celik, E | 1 |
| Armagan, HH | 1 |
| Uğuz, AC | 1 |
| Mayyas, F | 1 |
| Al-Taleb, Z | 1 |
| Mirkhani, H | 1 |
| Monabbati, A | 1 |
| Moghtadernejad, S | 1 |
| Aminsharifi, A | 1 |
| Atalay, Y | 1 |
| Gunes, N | 1 |
| Guner, MD | 1 |
| Akpolat, V | 1 |
| Celik, MS | 1 |
| Guner, R | 1 |
| Zang, Z | 1 |
| Li, S | 1 |
| Lin, Y | 1 |
| Li, X | 1 |
| Li, Y | 1 |
| Qin, Y | 1 |
| Wang, H | 1 |
| Jiang, M | 1 |
| Zhu, L | 1 |
| Dhiman, S | 1 |
| Mishra, N | 1 |
| Sharma, S | 1 |
| Chalmeh, A | 1 |
| Rahmani Shahraki, A | 1 |
| Heidari, SM | 1 |
| Badiei, K | 1 |
| Pourjafar, M | 1 |
| Nazifi, S | 1 |
| Zamiri, MJ | 1 |
| Minicucci, M | 1 |
| Oliveira, F | 1 |
| Santos, P | 1 |
| Polegato, B | 1 |
| Roscani, M | 1 |
| Fernandes, AA | 1 |
| Lustosa, B | 1 |
| Paiva, S | 1 |
| Zornoff, L | 1 |
| Azevedo, P | 1 |
| Cavalcanti, AL | 1 |
| Reis, MY | 1 |
| Silva, GC | 1 |
| Ramalho, ÍM | 1 |
| Guimarães, GP | 1 |
| Silva, JA | 1 |
| Saraiva, KL | 1 |
| Damasceno, BP | 1 |
| Li, Q | 1 |
| Hu, X | 1 |
| Sun, R | 1 |
| Tu, Y | 1 |
| Gong, F | 1 |
| Ni, Y | 1 |
| Kim, HK | 1 |
| Hwang, SH | 1 |
| Lee, SO | 1 |
| Kim, SH | 1 |
| Abdi, S | 1 |
| Goksu, E | 1 |
| Dogan, O | 1 |
| Ulker, P | 1 |
| Tanrıover, G | 1 |
| Konuk, E | 1 |
| Dilmac, S | 1 |
| Kirac, E | 1 |
| Demır, N | 1 |
| Aslan, M | 1 |
| Perelló, M | 1 |
| González-Foruria, I | 1 |
| Castillo, P | 1 |
| Martínez-Florensa, M | 1 |
| Lozano, F | 1 |
| Balasch, J | 1 |
| Carmona, F | 1 |
| Fichter, AM | 1 |
| Ritschl, LM | 1 |
| Robitzky, LK | 1 |
| Wagenpfeil, S | 1 |
| Mitchell, DA | 1 |
| Wolff, KD | 1 |
| Mücke, T | 1 |
| Roitinger, E | 1 |
| Schwarz, K | 1 |
| Karatay, E | 1 |
| Gül Utku, Ö | 1 |
| Erdal, H | 1 |
| Arhan, M | 1 |
| Önal, İK | 1 |
| Ibiş, M | 1 |
| Ekinci, Ö | 1 |
| Yilmaz Demirtaş, C | 1 |
| G Dumlu, Ş | 1 |
| Wei, T | 1 |
| Sabsovich, I | 1 |
| Guo, TZ | 1 |
| Shi, X | 1 |
| Zhao, R | 1 |
| Geis, C | 1 |
| Sommer, C | 1 |
| Kingery, WS | 1 |
| Clark, DJ | 1 |
| Demir, K | 1 |
| Sarioglu, S | 1 |
| Yesilirmak, DC | 1 |
| Kargi, A | 1 |
| de Campos, T | 2 |
| Deree, J | 4 |
| Martins, JO | 2 |
| Loomis, WH | 2 |
| Shenvi, E | 1 |
| Putnam, JG | 3 |
| Coimbra, R | 6 |
| Hung, KY | 1 |
| Huang, JW | 1 |
| Chiang, CK | 1 |
| Tsai, TJ | 4 |
| Menon, RT | 1 |
| Feferman, T | 1 |
| Aricha, R | 1 |
| Souroujon, MC | 1 |
| Fuchs, S | 1 |
| Ng, YY | 2 |
| Lan, XR | 1 |
| Yang, WC | 1 |
| Lan, HY | 2 |
| Emrecan, B | 2 |
| Tulukoğlu, E | 2 |
| Bozok, S | 2 |
| Aksun, M | 1 |
| Yağdi, S | 2 |
| Ozcan, AV | 1 |
| Saçar, M | 1 |
| Gürbüz, A | 2 |
| Cerqueira, NF | 1 |
| Hussni, CA | 1 |
| Yoshida, WB | 1 |
| Sequeira, JL | 1 |
| Padovani, CR | 1 |
| Zhou, QG | 1 |
| Zheng, FL | 1 |
| Hou, FF | 1 |
| Luo, B | 1 |
| Tang, L | 1 |
| Wang, Y | 1 |
| Stockard, CR | 1 |
| Kadish, I | 1 |
| Van Groen, T | 1 |
| Grizzle, WE | 1 |
| Ponnazhagan, S | 1 |
| Fallon, MB | 1 |
| Vlahos, NF | 1 |
| Gregoriou, O | 1 |
| Deliveliotou, A | 1 |
| Perrea, D | 1 |
| Vlachos, A | 1 |
| Zhao, Y | 1 |
| Lai, J | 1 |
| Creatsas, G | 1 |
| Mendes, JB | 1 |
| Campos, PP | 1 |
| Rocha, MA | 1 |
| Andrade, SP | 1 |
| Groesdonk, HV | 1 |
| Bauer, A | 1 |
| Kreft, B | 1 |
| Heringlake, M | 1 |
| Paarmann, H | 1 |
| Pagel, H | 1 |
| Oksuz, H | 2 |
| Bulbuloglu, E | 2 |
| Senoglu, N | 2 |
| Ciralik, H | 1 |
| Yuzbasioglu, MF | 2 |
| Kilinc, M | 2 |
| Dogan, Z | 2 |
| Goksu, M | 1 |
| Yildiz, H | 2 |
| Ozkan, OV | 1 |
| Atli, Y | 2 |
| Mika, J | 3 |
| Osikowicz, M | 3 |
| Rojewska, E | 1 |
| Korostynski, M | 1 |
| Wawrzczak-Bargiela, A | 1 |
| Przewlocki, R | 1 |
| Przewlocka, B | 3 |
| Skup, M | 1 |
| Makuch, W | 2 |
| Czarkowska-Bauch, J | 1 |
| Okumura, AS | 1 |
| Rodrigues, LE | 1 |
| Martinelli, R | 1 |
| Bansal, S | 1 |
| Wang, W | 3 |
| Falk, S | 2 |
| Schrier, R | 2 |
| Andrade, Wde C | 2 |
| Tannuri, U | 2 |
| da Silva, LF | 1 |
| Alves, VA | 2 |
| Oliveira-Júnior, IS | 3 |
| Oliveira, IS | 1 |
| Oliveira, WR | 1 |
| Cavassani, SS | 1 |
| Brunialti, MK | 2 |
| Salomao, R | 2 |
| Amabeoku, GJ | 1 |
| Erasmus, SJ | 1 |
| Ojewole, JA | 1 |
| Mukinda, JT | 1 |
| Ji, Q | 3 |
| Jia, H | 3 |
| Dai, H | 1 |
| Zhang, L | 3 |
| Costantini, TW | 1 |
| Campos, Td | 1 |
| Albersen, M | 1 |
| Fandel, TM | 1 |
| Banie, L | 1 |
| Lin, G | 1 |
| De Ridder, D | 1 |
| Lin, CS | 1 |
| Lue, TF | 1 |
| Ozkurkcugil, C | 1 |
| Yilmaz, MY | 1 |
| Ozkan, L | 1 |
| Kokturk, S | 1 |
| Isken, T | 1 |
| Vakili, A | 2 |
| Mojarrad, S | 1 |
| Akhavan, MM | 1 |
| Rashidy-Pour, A | 1 |
| Zaitone, S | 1 |
| Hassan, N | 1 |
| El-Orabi, N | 1 |
| El-Awady, el-S | 1 |
| Peterson, TC | 3 |
| Peterson, MR | 1 |
| Raoul, JM | 1 |
| Bah, TM | 1 |
| Kaloustian, S | 2 |
| Rousseau, G | 2 |
| Godbout, R | 2 |
| Asvadi, I | 1 |
| Hajipour, B | 1 |
| Asvadi, A | 1 |
| Asl, NA | 1 |
| Roshangar, L | 1 |
| Khodadadi, A | 1 |
| Coskuner, I | 1 |
| Deniz, C | 1 |
| Kantarçeken, B | 1 |
| Sümer, A | 1 |
| Altınlı, E | 1 |
| Senger, S | 1 |
| Köksal, N | 1 |
| Onur, E | 1 |
| Eroğlu, E | 1 |
| Güneş, P | 1 |
| Erken, HY | 1 |
| Ofluoglu, O | 1 |
| Aktas, M | 1 |
| Topal, C | 1 |
| Yildiz, M | 1 |
| Seifi, B | 1 |
| Kadkhodaee, M | 1 |
| Delavari, F | 1 |
| Mikaeili, S | 1 |
| Shams, S | 1 |
| Ostad, SN | 1 |
| Mati, VL | 1 |
| Melo, AL | 1 |
| Kim, HJ | 1 |
| Lee, KH | 1 |
| Turhan, AH | 1 |
| Atıcı, A | 1 |
| Muşlu, N | 1 |
| Polat, A | 1 |
| Helvacı, İ | 1 |
| Kim, H | 1 |
| Kim, Y | 1 |
| Guk, K | 1 |
| Yoo, D | 1 |
| Lim, H | 1 |
| Kang, G | 1 |
| Lee, D | 1 |
| Sun, HK | 1 |
| Lee, YM | 1 |
| Han, KH | 1 |
| Kim, HS | 1 |
| Ahn, SH | 1 |
| Han, SY | 1 |
| Silva, LF | 1 |
| Coelho, MC | 1 |
| Tannuri, AC | 1 |
| Ramallo, BT | 1 |
| Lourenço, E | 1 |
| Cruz, RH | 1 |
| Almeida, JC | 1 |
| Silva, PY | 1 |
| Parra, A | 1 |
| García-Olmos, M | 1 |
| Nieto, E | 1 |
| García-Calvo, G | 1 |
| Ponte, C | 1 |
| Soriano, F | 1 |
| Kocdor, MA | 1 |
| Kocdor, H | 1 |
| Gulay, Z | 1 |
| Gokce, O | 1 |
| Rübe, CE | 1 |
| Wilfert, F | 1 |
| Uthe, D | 1 |
| Schmid, KW | 1 |
| Knoop, R | 1 |
| Willich, N | 1 |
| Schuck, A | 1 |
| Rübe, C | 1 |
| Viana, CF | 1 |
| Melo, DH | 1 |
| Carneiro-Filho, BA | 1 |
| Michelin, MA | 1 |
| Lima, AA | 1 |
| Yildirim, S | 1 |
| Tok, H | 1 |
| Köksal, H | 1 |
| Erdem, L | 1 |
| Baykan, A | 1 |
| Tarçin, O | 2 |
| Avşar, K | 1 |
| Demirtürk, L | 1 |
| Gültepe, M | 1 |
| Oktar, BK | 1 |
| Ozdoğan, OC | 1 |
| Baloğlu, H | 1 |
| Gürbüz, AK | 1 |
| Yagmurlu, A | 1 |
| Boleken, ME | 1 |
| Ertoy, D | 1 |
| Ozsan, M | 1 |
| Gokcora, IH | 1 |
| Dindar, H | 3 |
| Jean Harry, G | 1 |
| Bruccoleri, A | 1 |
| Lefebvre d'Hellencourt, C | 1 |
| Sant, VP | 2 |
| Nagarsenker, MS | 2 |
| Rao, SG | 2 |
| Gude, RP | 3 |
| Kim, YK | 1 |
| Choi, TR | 1 |
| Kwon, CH | 1 |
| Kim, JH | 1 |
| Woo, JS | 1 |
| Jung, JS | 1 |
| Granell, S | 1 |
| Pereda, J | 1 |
| Gómez-Cambronero, L | 1 |
| Cassinello, N | 1 |
| Sabater, L | 1 |
| Closa, D | 1 |
| Sastre, J | 1 |
| Banfi, C | 1 |
| Sironi, L | 1 |
| De Simoni, G | 1 |
| Gelosa, P | 1 |
| Barcella, S | 1 |
| Perego, C | 1 |
| Gianazza, E | 1 |
| Guerrini, U | 1 |
| Tremoli, E | 1 |
| Mussoni, L | 1 |
| Kwiecień, S | 1 |
| Brzozowski, T | 1 |
| Konturek, PC | 1 |
| Pawlik, MW | 1 |
| Pawlik, WW | 1 |
| Kwiecień, N | 1 |
| Konturek, SJ | 1 |
| Yada-Langui, MM | 1 |
| Anjos-Valotta, EA | 1 |
| Rocha e Silva, M | 1 |
| Modzelewski, B | 2 |
| Janiak, A | 1 |
| Czarnecki, P | 1 |
| Markert, R | 1 |
| Gunduz, Z | 1 |
| Canoz, O | 1 |
| Per, H | 1 |
| Dusunsel, R | 1 |
| Poyrazoglu, MH | 1 |
| Tez, C | 1 |
| Saraymen, R | 1 |
| Osterreicher, J | 1 |
| Pejchal, J | 1 |
| Skopek, J | 1 |
| Mokrỳ, J | 1 |
| Vilasová, Z | 1 |
| Psutka, J | 1 |
| Vávrová, J | 1 |
| Mazurová, Y | 1 |
| Xu, J | 4 |
| Marshall, JC | 1 |
| Rebouças, CG | 1 |
| Falcão, BA | 1 |
| Augusto, RF | 1 |
| Souza, ML | 1 |
| Leitão, BT | 1 |
| Pei, H | 1 |
| Gu, J | 1 |
| Thimmalapura, PR | 1 |
| Mison, A | 1 |
| Nadler, JL | 1 |
| Bluthé, RM | 1 |
| Frenois, F | 1 |
| Kelley, KW | 1 |
| Dantzer, R | 1 |
| Wann, BP | 1 |
| Boucher, M | 1 |
| Nim, S | 1 |
| Fukuda, T | 1 |
| Mogami, A | 1 |
| Hisadome, M | 1 |
| Komatsu, H | 1 |
| Dorchies, OM | 1 |
| Wagner, S | 1 |
| Vuadens, O | 1 |
| Waldhauser, K | 1 |
| Buetler, TM | 1 |
| Kucera, P | 1 |
| Ruegg, UT | 1 |
| Spadaro, JA | 1 |
| Horton, JA | 1 |
| Margulies, BS | 1 |
| Luther, J | 1 |
| Strauss, JA | 1 |
| Farnum, CE | 1 |
| Damron, TA | 1 |
| Genc, A | 1 |
| Taneli, F | 1 |
| Demireli, P | 1 |
| Deveci Kocakoc, I | 1 |
| Sencan, A | 1 |
| Gunsar, C | 1 |
| Mir, E | 1 |
| Taneli, C | 1 |
| Porcides, R | 1 |
| Loomis, W | 2 |
| Melbostad, H | 2 |
| Lall, R | 1 |
| Wolf, P | 3 |
| Hoyt, DB | 2 |
| Porcides, RD | 1 |
| Tobar, M | 1 |
| Gosselin, LE | 1 |
| Williams, JE | 1 |
| Noyan, T | 1 |
| Kömüroğlu, U | 1 |
| Bayram, I | 1 |
| Sekeroğlu, MR | 1 |
| Oztuna, V | 1 |
| Eskandari, MM | 1 |
| Unal, S | 1 |
| Colak, M | 1 |
| Karabacak, T | 1 |
| Lv, R | 1 |
| Travadi, J | 1 |
| Patole, S | 1 |
| Charles, A | 1 |
| Dvorak, B | 1 |
| Doherty, D | 1 |
| Simmer, K | 1 |
| Kestelli, M | 1 |
| Onem, G | 1 |
| Küpelioglu, A | 1 |
| Zolty, E | 1 |
| Basava, V | 1 |
| Reznikov, L | 1 |
| Liu, J | 2 |
| Feng, X | 2 |
| Yu, M | 1 |
| Zhao, X | 1 |
| Guan, R | 2 |
| Koh, IH | 1 |
| Junqueira, VB | 1 |
| Rosenberg, GA | 1 |
| Estrada, EY | 1 |
| Mobashery, S | 1 |
| Unal, C | 1 |
| Sen, C | 1 |
| Iscen, D | 1 |
| Dalcik, H | 1 |
| Zahedi khorasani, M | 1 |
| El-Lakkany, N | 1 |
| Nosseir, M | 1 |
| Yalniz, M | 1 |
| Bahçecioğlu, IH | 1 |
| Kuzu, N | 1 |
| Celebi, S | 1 |
| Ataseven, H | 1 |
| Ustündağ, B | 1 |
| Ozercan, IH | 1 |
| Sahin, K | 1 |
| Duan, YY | 1 |
| Xue, ZQ | 1 |
| Meng, JG | 1 |
| Ding, XM | 1 |
| Peng, CS | 1 |
| Wang, DP | 1 |
| Melo, ML | 1 |
| Soares, RC | 1 |
| Carvalho, SB | 1 |
| Silva, JV | 1 |
| Soares, PM | 1 |
| Vale, ML | 1 |
| Souza, MH | 1 |
| Tukov, FF | 1 |
| Luyendyk, JP | 1 |
| Ganey, PE | 2 |
| Roth, RA | 2 |
| Shaw, PJ | 1 |
| Hopfensperger, MJ | 1 |
| Martins, J | 1 |
| Tariq, M | 1 |
| Moutaery, KA | 1 |
| Deeb, SA | 1 |
| Rodríguez-Morán, M | 1 |
| Guerrero-Romero, F | 1 |
| Zhu, J | 1 |
| Sage, E | 1 |
| Mercier, O | 1 |
| Van den Eyden, F | 1 |
| de Perrot, M | 1 |
| Barlier-Mur, AM | 1 |
| Dartevelle, P | 1 |
| Eddahibi, S | 1 |
| Herve, P | 1 |
| Fadel, E | 1 |
| Kajana, S | 1 |
| Goshgarian, HG | 1 |
| Kang, YM | 1 |
| Zhang, ZH | 1 |
| Weiss, RM | 1 |
| Gallenkämper, W | 1 |
| Rücker, W | 1 |
| Schrör, K | 1 |
| Kirpatovskiĭ, VI | 1 |
| Onishchenko, NA | 1 |
| Lubiako, AA | 1 |
| Danilov, MA | 1 |
| Bogoiavlenskaia, TA | 1 |
| Sugiura, Y | 1 |
| Kato, T | 1 |
| Goto, Y | 1 |
| Yamamoto, K | 1 |
| Aochi, O | 1 |
| Steen, PA | 1 |
| Michenfelder, JD | 1 |
| Carter, MB | 1 |
| Wilson, MA | 1 |
| Wead, WB | 1 |
| Garrison, RN | 1 |
| Kiely, PD | 1 |
| Gillespie, KM | 1 |
| Oliveira, DB | 1 |
| Badger, AM | 1 |
| Olivera, DL | 1 |
| Esser, KM | 1 |
| Lundblad, R | 1 |
| Ekstrøm, P | 1 |
| Giercksky, KE | 1 |
| Refsum, SE | 2 |
| McCaigue, M | 2 |
| Campbell, GR | 1 |
| Barclay, GR | 1 |
| Erwin, PJ | 1 |
| Rowlands, BJ | 2 |
| Boston, VE | 2 |
| Halliday, MI | 2 |
| Bassi, DG | 1 |
| Foitzik, T | 1 |
| Rattner, DW | 1 |
| Lewandrowski, K | 1 |
| Warshaw, AL | 1 |
| Fernández-del Castillo, C | 1 |
| Hadjiminas, DJ | 1 |
| McMasters, KM | 1 |
| Robertson, SE | 1 |
| Cheadle, WG | 1 |
| Stadler, I | 1 |
| Chadha, KC | 1 |
| Nakeeb, S | 1 |
| Toumbis, C | 1 |
| Butsch, J | 1 |
| Mathur, N | 1 |
| Munschauer, F | 1 |
| Vladutiu, A | 1 |
| Satchidanand, SK | 1 |
| Ambrus, JL | 3 |
| Cortijo, J | 1 |
| Bou, J | 1 |
| Beleta, J | 1 |
| Cardelús, I | 1 |
| Llenas, J | 1 |
| Morcillo, E | 1 |
| Gristwood, RW | 1 |
| Mah, MP | 1 |
| Aeberhard, EE | 1 |
| Gilliam, MB | 1 |
| Sherman, MP | 1 |
| Reddington, TM | 1 |
| Meky, NN | 1 |
| Conway, J | 1 |
| Koch, H | 1 |
| Okyayuz-Baklouti, I | 1 |
| Norris, D | 1 |
| Kogler, H | 1 |
| Leibfritz, D | 1 |
| Marzi, I | 1 |
| Maier, M | 1 |
| Herzog, C | 1 |
| Bauer, M | 1 |
| Kaye, AD | 1 |
| Ibrahim, IN | 1 |
| Kadowitz, PJ | 1 |
| Nossaman, BD | 1 |
| Campbell, G | 1 |
| Neumeister, M | 1 |
| Wada, K | 1 |
| Kamisaki, Y | 1 |
| Kitano, M | 1 |
| Kishimoto, Y | 1 |
| Nakamoto, K | 1 |
| Itoh, T | 1 |
| Sánchez, S | 1 |
| Albornoz, L | 1 |
| Bandi, JC | 1 |
| Gerona, S | 1 |
| Mastai, R | 1 |
| Hasegawa, N | 2 |
| Oka, Y | 2 |
| Nakayama, M | 2 |
| Berry, GJ | 1 |
| Bursten, S | 1 |
| Rice, G | 1 |
| Raffin, TA | 2 |
| Evliyaoğlu, Y | 1 |
| Kayrin, L | 1 |
| Kaya, B | 1 |
| Brzychcy, M | 1 |
| Klink, M | 1 |
| Tchórzewski, H | 1 |
| Rudnicka, W | 1 |
| Savaş, C | 3 |
| Aras, T | 2 |
| Cakmak, M | 1 |
| Bilgehan, A | 1 |
| Ataoğlu, O | 1 |
| Türközkan, N | 1 |
| Ozgüner, F | 1 |
| Yücesan, S | 2 |
| Davey, K | 1 |
| Arias-Díaz, J | 1 |
| Vara, E | 1 |
| Torres-Melero, J | 1 |
| García, C | 1 |
| Hernández, J | 1 |
| Balibrea, JL | 1 |
| Baskett, A | 1 |
| Barton, MH | 2 |
| Norton, N | 2 |
| Anders, B | 1 |
| Moore, JN | 2 |
| Ladny, JR | 1 |
| Dzienis, H | 1 |
| Dadan, J | 1 |
| Polaków, J | 1 |
| Venskutonis, D | 1 |
| Puchalski, Z | 1 |
| Waxman, K | 1 |
| Wang, P | 2 |
| Chaudry, IH | 2 |
| Sulkowska, M | 1 |
| Fomochkin, II | 1 |
| Quezado, ZM | 1 |
| Hoffman, WD | 1 |
| Banks, SM | 1 |
| Danner, RL | 1 |
| Eichacker, PQ | 1 |
| Susla, GM | 1 |
| Natanson, C | 1 |
| Murphy, GA | 1 |
| Sussman, HH | 1 |
| Nelson, JL | 1 |
| Alexander, JW | 1 |
| Mao, JX | 1 |
| Vohs, T | 1 |
| Ogle, CK | 1 |
| Reynolds, H | 1 |
| Heller, S | 1 |
| Weber, K | 1 |
| Heller, A | 1 |
| Urbaschek, R | 1 |
| Koch, T | 1 |
| Evans, SM | 1 |
| Pinto Pereira, LM | 1 |
| Addae, JI | 1 |
| Rao, VS | 1 |
| Santos, FA | 1 |
| Paula, WG | 1 |
| Silva, RM | 1 |
| Campos, AR | 1 |
| Wu, CC | 1 |
| Liao, MH | 1 |
| Chen, SJ | 1 |
| Yen, MH | 1 |
| Chien, CT | 1 |
| Hu-Tsai, MI | 1 |
| Tsai, CC | 1 |
| Wu, MS | 1 |
| Hansen, PR | 1 |
| Holm, AM | 1 |
| Qi, JH | 1 |
| Ledet, T | 1 |
| Rasmussen, LM | 1 |
| Andersen, CB | 1 |
| Jarrar, D | 1 |
| Parker, SJ | 1 |
| Brown, D | 1 |
| Kenward, CE | 1 |
| Watkins, PE | 1 |
| Akpolat, T | 1 |
| Akpolat, I | 1 |
| Sarikaya, S | 1 |
| Coşar, AM | 1 |
| Bedir, A | 1 |
| Kandemir, B | 1 |
| Vyavahare, N | 1 |
| Jones, PL | 1 |
| Tallapragada, S | 1 |
| Levy, RJ | 1 |
| Sherer, JT | 1 |
| Glover, PH | 1 |
| de Souza, MM | 1 |
| Silva, LM | 1 |
| Barbosa, AA | 1 |
| de Oliveira , IR | 1 |
| Paraná, R | 1 |
| Andrade, ZA | 1 |
| Beshay, E | 1 |
| Croze, F | 1 |
| Prud'homme, GJ | 1 |
| Gaikwad, SY | 1 |
| Jagtap, AG | 1 |
| Ingle, AD | 1 |
| Ra, SG | 1 |
| Schwarz, EM | 1 |
| Benz, EB | 1 |
| Lu, AP | 1 |
| Goater, JJ | 1 |
| Mollano, AV | 1 |
| Rosier, RN | 1 |
| Puzas, JE | 1 |
| Okeefe, RJ | 1 |
| Persidsky, Y | 1 |
| Limoges, J | 1 |
| Rasmussen, J | 1 |
| Zheng, J | 1 |
| Gearing, A | 1 |
| Gendelman, HE | 1 |
| Gale, SC | 1 |
| Hokama, JY | 1 |
| Ritter, LS | 1 |
| Gorman, GD | 1 |
| Copeland, JG | 1 |
| McDonagh, PF | 1 |
| Bright, JJ | 1 |
| Sriram, S | 1 |
| Laurat, E | 1 |
| Poirier, B | 1 |
| Tupin, E | 1 |
| Caligiuri, G | 1 |
| Hansson, GK | 1 |
| Bariéty, J | 1 |
| Nicoletti, A | 1 |
| Köylüoglu, G | 1 |
| Bakici, MZ | 1 |
| Elagöz, S | 1 |
| Arpacik, M | 1 |
| Savaş, S | 1 |
| Delibaş, N | 1 |
| Sütçü, R | 1 |
| Cindaş, A | 1 |
| Voza, T | 1 |
| Gautret, P | 1 |
| Renia, L | 1 |
| Gantier, JC | 1 |
| Lombard, MN | 1 |
| Chabaud, AG | 1 |
| Landau, I | 1 |
| Krupiński, K | 1 |
| Breddin, HK | 1 |
| Bielawiec, M | 1 |
| Płonowski, A | 1 |
| Sonkin, PL | 1 |
| Freedman, SF | 1 |
| Needham, D | 1 |
| Rao, KM | 1 |
| Hatchell, DL | 1 |
| Law, WR | 1 |
| Nadkarni, VM | 1 |
| Fletcher, MA | 1 |
| Nevola, JJ | 1 |
| Eckstein, JM | 1 |
| Quance, J | 1 |
| McKenna, TM | 1 |
| Lee, CH | 1 |
| Williams, TJ | 1 |
| Gibson, RL | 1 |
| Truog, WE | 1 |
| Henderson, WR | 1 |
| Redding, GJ | 1 |
| Masouyé, P | 1 |
| Gunning, K | 1 |
| Pittet, JF | 1 |
| Suter, PM | 1 |
| Morel, DR | 1 |
| Giroir, BP | 1 |
| Beutler, B | 1 |
| Oropello, JM | 1 |
| Amin, D | 1 |
| Klapholtz, A | 1 |
| Benjamin, E | 1 |
| Fischer, E | 1 |
| Jacobs, E | 1 |
| Iberti, TJ | 1 |
| Steinleitner, A | 1 |
| Lambert, H | 1 |
| Chung, TW | 1 |
| O'Rear, EA | 1 |
| Whitsett, TL | 1 |
| Hinshaw, LB | 1 |
| Smith, MA | 1 |
| Anain, JM | 2 |
| Anain, SM | 1 |
| Anain, PM | 1 |
| Stadler, S | 1 |
| Mitchell, P | 1 |
| Brobst, JA | 1 |
| Cobert, BL | 1 |
| Savitsky, JP | 1 |
| Brunner, LJ | 2 |
| Vadiei, K | 2 |
| Iyer, LV | 1 |
| Luke, DR | 2 |
| Sáez-Llorens, X | 1 |
| Ramilo, O | 1 |
| Mustafa, MM | 1 |
| Mertsola, J | 1 |
| Hansen, EJ | 1 |
| McCracken, GH | 1 |
| Schönharting, MM | 1 |
| Schade, UF | 1 |
| Tkácová, R | 1 |
| Tomori, Z | 1 |
| Nistiarová, A | 1 |
| Campbell, CA | 1 |
| Clavenna, CF | 1 |
| Wynne, J | 1 |
| Kloner, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial of Pentoxifylline in Newly-Diagnosed Biliary Atresia[NCT01774487] | Phase 2 | 17 participants (Actual) | Interventional | 2013-02-04 | Terminated (stopped due to Target enrollment was not reached because the medication, pentoxifylline, has a taste that is not well tolerated by infants. The study team decided to end the study before meeting the enrollment goal because of the medication taste.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The investigators will record the ALT levels at age two years, in patients who had previously been treated with PTX therapy and still have their native liver. Scale 14-45 U/L, with a higher level indicating a worse outcome. (NCT01774487)
Timeframe: 2 years of age
| Intervention | U/L (Mean) |
|---|---|
| Pentoxifylline - Group 1 | 160 |
The investigators will track the weight of patients over the course of therapy in patients receiving 90 days of PTX (this is recorded as part of routine clinical care). The weight will then be compared to standards to calculate a z-score. Normal weight Z-score is greater than or equal to 0, with a higher number of patients meeting this indicating a better outcome. (NCT01774487)
Timeframe: 12 weeks after starting therapy
| Intervention | Participants (Count of Participants) |
|---|---|
| Pentoxifylline - Group 1 | 0 |
| Group 2 | 0 |
The investigators will track the serum conjugated bilirubin (CB) levels over the course of therapy in patients receiving 90 days of PTX (this laboratory test is drawn as part of routine care). Normal CB is 0.0-0.3 mg/dL, with a higher number of patients meeting this indicating a better outcome. (NCT01774487)
Timeframe: 12 weeks after starting therapy
| Intervention | Participants (Count of Participants) |
|---|---|
| Pentoxifylline - Group 1 | 6 |
| Pentoxifylline - Group 2 | 0 |
The investigators will record platelet levels at age two years, in patients who had previously been treated with PTX therapy and still have their native liver. Scale 189-403*10^3 Platelets/μL, with a lower level indicating a worse outcome. (NCT01774487)
Timeframe: 2 years of age
| Intervention | 10^3 Platelets/μL (Mean) |
|---|---|
| Pentoxifylline - Group 1 | 208 |
"The investigators will measure spleen size by ultrasound at 2 years of age, in patients who had received PTX therapy earlier and still have their native liver. Normal spleen size range (10th-90th percentile) at this age is 6.4-8.6 cm, with a value exceeding this range indicating a worse outcome." (NCT01774487)
Timeframe: 2 years of age
| Intervention | cm (Mean) |
|---|---|
| Pentoxifylline - Group 1 | 10.0 |
The investigators will track time to liver transplant. The shorter time to liver transplant indicates a worse outcome. (NCT01774487)
Timeframe: Baseline and up to two years after therapy finishes
| Intervention | days (Mean) |
|---|---|
| Pentoxifylline - Group 1 | 317 |
| Pentoxifylline - Group 2 | 273 |
8 reviews available for pentoxifylline and Disease Models, Animal
| Article | Year |
|---|---|
Alcoholic hepatitis: Prognosis and treatment.
Topics: Alcohol Deterrents; Animals; Antibodies, Monoclonal; Disease Models, Animal; Etanercept; Fatty Liver | 2014 |
Efficacy of pentoxifylline in the management of microalbuminuria in patients with diabetes.
Topics: Albuminuria; Animals; Diabetic Angiopathies; Diabetic Nephropathies; Disease Models, Animal; Glomeru | 2008 |
"Stiff red cell syndrome". A review of the treatment of sickle cell disease with pentoxifylline.
Topics: Animals; Disease Models, Animal; Erythrocytes; Humans; Macaca; Microcirculation; Pentoxifylline; Pla | 1993 |
Pentoxifylline--more evidence that it improves host defenses during sepsis.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Free Radical Scavengers; Humans; Infl | 1999 |
Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches (Review).
Topics: Adenosine Triphosphate; Animals; Coloring Agents; Critical Care; Cytokines; Diltiazem; Disease Model | 1999 |
Pentoxifylline for sickle-cell disease.
Topics: Anemia, Sickle Cell; Animals; Clinical Trials as Topic; Disease Models, Animal; Female; Haplorhini; | 2000 |
Immunotherapy of inflammatory demyelinating diseases of the central nervous system.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; CD4-Positive T-Lymphocytes; Cerebrospinal F | 2001 |
The effect of pentoxifylline in septic shock--new pharmacologic aspects of an established drug.
Topics: Animals; Disease Models, Animal; Mice; Pentoxifylline; Shock, Septic; Theobromine | 1989 |
1 trial available for pentoxifylline and Disease Models, Animal
| Article | Year |
|---|---|
Dose-response effects of pentoxifylline on erythrocyte filterability: clinical and animal model studies.
Topics: Animals; Arteriosclerosis; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocyte Def | 1990 |
253 other studies available for pentoxifylline and Disease Models, Animal
| Article | Year |
|---|---|
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Anti-I | 1996 |
Synthesis and bioactivities of novel bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.
Topics: Animals; Arthritis, Experimental; Bridged Bicyclo Compounds; Disease Models, Animal; Inhibitory Conc | 2002 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Cryoprotective Effect of Pentoxifylline on Spermatogonial Stem Cell During Transplantation into Azoospermic Torsion Mouse Model.
Topics: Adult Germline Stem Cells; Animals; Azoospermia; Cryopreservation; Cryoprotective Agents; Disease Mo | 2022 |
Novel Co-crystal of Pentoxifylline and Protocatechuic Acid Relieves Allodynia in Rat Models of Peripheral Neuropathic Pain and CRPS by Alleviating Local Tissue Hypoxia.
Topics: Animals; Complex Regional Pain Syndromes; Disease Models, Animal; Hydroxybenzoates; Hyperalgesia; Hy | 2021 |
Decrease of Tumor-infiltrating Regulatory T Cells Using Pentoxifylline: An Ex Vivo Analysis in Triple-negative Breast Cancer Mouse Model.
Topics: Animals; Disease Models, Animal; Humans; Lymphocytes, Tumor-Infiltrating; Mice; Pentoxifylline; T-Ly | 2022 |
Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Fibrosis; Gene Expression Pr | 2023 |
Evaluation of antifibrotic and antifungal combined therapies in experimental pulmonary paracoccidioidomycosis.
Topics: Animals; Antifungal Agents; Azithromycin; Cytokines; Disease Models, Animal; Drug Therapy, Combinati | 2020 |
Blockade of angiotensin-converting enzyme or tumor necrosis factor-α reverses maternal high-fat diet-induced sensitization of angiotensin II hypertension in male rat offspring.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animal Nutritional Physiological Phenomena | 2020 |
Pentoxifylline alleviated cardiac injury via modulating the cardiac expression of lncRNA-00654-miR-133a-SOX5 mRNA in the rat model of ischemia-reperfusion.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; | 2020 |
The effect of pentoxifylline on cerebral vasospasm following experimental subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Disease Models, Animal; Male; Pentoxifylline; Rabbits; Subarachnoid Hemorrh | 2021 |
Effects of pentoxifylline and tocopherol on an osteoradionecrosis animal model.
Topics: Animals; Disease Models, Animal; Osteoradionecrosis; Pentoxifylline; Rats; Rats, Sprague-Dawley; Toc | 2020 |
Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19.
Topics: Alveolar Epithelial Cells; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Complement Acti | 2020 |
TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relat | 2020 |
Lisofylline mitigates cardiac inflammation in a mouse model of obesity through improving insulin secretion and activating cardiac AMPK signaling pathway.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Apoptosis; Blood Glucose; Body Weight; Disea | 2021 |
The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis.
Topics: Animals; Aspirin; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Reposit | 2021 |
Therapeutic effects of pentoxifylline on invasive pulmonary aspergillosis in immunosuppressed mice.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Bronchoalveolar Lavage Fluid; Chitinases; Disease | 2021 |
Pentoxifylline treatment alleviates kidney ischemia/reperfusion injury: Novel involvement of galectin-3 and ASK-1/JNK & ERK1/2/NF-κB/HMGB-1 trajectories.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Galectin 3; HMGB1 Protein; | 2021 |
Impacts of anti-inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Cyclopropanes; Disease Models, Animal | 2021 |
Role of N-acetyl galactosamine-4-SO
Topics: Acetylgalactosamine; Animals; Behcet Syndrome; Colchicine; Disease Models, Animal; Dose-Response Rel | 2017 |
The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats.
Topics: Animals; Disease Models, Animal; Intestines; Ischemic Preconditioning; Male; Pentoxifylline; Rats; R | 2017 |
Pentoxifylline treatment enhances antihypertensive activity of captopril through hemorheological improvement in spontaneously hypertensive rats during development of arterial hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Blood Vi | 2017 |
Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Caspase 3; Cyclooxygenase 2; Cytokines; Disease M | 2018 |
The expression of endothelial and inducible nitric oxide synthase and apoptosis in intestinal ischemia and reperfusion injury under the action of ischemic preconditioning and pentoxifylline.
Topics: Animals; Apoptosis; Disease Models, Animal; Humans; Immunohistochemistry; Intestinal Diseases; Intes | 2017 |
The protective effect of pentoxifylline versus silymarin on the pancreas through increasing adenosine by CD39 in a rat model of liver cirrhosis: Pharmacological, biochemical and histological study.
Topics: Adenosine; Amylases; Animals; Antigens, CD; Apyrase; Disease Models, Animal; Insulin-Secreting Cells | 2018 |
Comparing the antifibrotic effect on the liver of Telmisartan and Pentoxifylline, in a Wistar rat experimental model.
Topics: Animals; Benzimidazoles; Benzoates; Disease Models, Animal; Fibrosis; Liver; Models, Theoretical; Pe | 2017 |
Pentoxifylline prevents post-traumatic stress disorder induced memory impairment.
Topics: Animals; Brain-Derived Neurotrophic Factor; Catalase; Disease Models, Animal; Free Radical Scavenger | 2018 |
Inhibition of Aortic Calcification by Policosanol in Dyslipidemic Rabbits Is Enhanced by Pentoxifylline: Potential Role of PCSK9.
Topics: Alkaline Phosphatase; Animals; Anticholesteremic Agents; Aorta; Aortic Diseases; Biomarkers; Bone Mo | 2018 |
Protective effect of pentoxifylline on oxidative renal cell injury associated with renal crystal formation in a hyperoxaluric rat model.
Topics: Animals; Cell Death; Disease Models, Animal; Free Radical Scavengers; Hyperoxaluria; Kidney Calculi; | 2019 |
Protective effects of pentoxifylline in small intestine after ischemia-reperfusion.
Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Hematologic Agents; Infusions, Parenteral; I | 2018 |
Protective effect of pentoxifylline on amikacin-induced ototoxicity.
Topics: Amikacin; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Administration Routes; Drug A | 2018 |
Role of pentoxifylline and iloprost in the prevention of ischemia-reperfusion injury in an experimental model of intestine ischemia-reperfusion in rats.
Topics: Animals; Disease Models, Animal; Free Radical Scavengers; Ileal Diseases; Ileum; Male; Pentoxifyllin | 2018 |
Salvaging the Zone of Stasis in Burns by Pentoxifylline: An Experimental Study in Rats.
Topics: Animals; Burns; Disease Models, Animal; Male; Pentoxifylline; Rats; Rats, Sprague-Dawley; Wound Heal | 2019 |
Effect of selenium and pentoxifylline on expression of CATSPER1 and 2 genes and FSH/LH levels in treated mice by dexamethasone.
Topics: Animals; Antioxidants; Calcium Channels; Dexamethasone; Disease Models, Animal; Follicle Stimulating | 2019 |
Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Brain; Captopril; | 2019 |
Hypertonic saline and pentoxifylline enhance survival, reducing apoptosis and oxidative stress in a rat model of strangulated closed loop small bowel obstruction.
Topics: Animals; Apoptosis; Disease Models, Animal; Immunohistochemistry; In Situ Nick-End Labeling; Intesti | 2019 |
The Akt/FoxO/p27
Topics: Animals; Cell Cycle Checkpoints; Cell Proliferation; Cicatrix, Hypertrophic; Cyclin-Dependent Kinase | 2019 |
Role of Myocardial Infarction-Induced Neuroinflammation for Depression-Like Behavior and Heart Failure in Ovariectomized Female Rats.
Topics: Animals; Behavior Rating Scale; Brain-Derived Neurotrophic Factor; Cytokines; Depression; Disease Mo | 2019 |
Effects of intravenous administration of pentoxifylline in pancreatic ischaemia-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Inflammation Mediators; Injec | 2013 |
Evaluation of the effect of pentoxifylline on sleep-deprivation induced memory impairment.
Topics: Analysis of Variance; Animals; Calorimetry; Catalase; Disease Models, Animal; Glutathione; Glutathio | 2013 |
Protective effects of pentoxifylline on lipopolysaccharide-induced white matter injury in a rat model of periventricular leukomalasia.
Topics: Animals; Animals, Newborn; Cytoprotection; Disease Models, Animal; Drug Evaluation, Preclinical; Fem | 2013 |
Uroprotective effect of pentoxifylline in cyclophosphamide-induced hemorrhagic cystitis in rats.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Cyclophosphamide; Cystitis; Cytokines; Dis | 2013 |
Pentoxifylline protects the small intestine after severe ischemia and reperfusion.
Topics: Animals; Biomarkers; Blood Flow Velocity; Cytoprotection; Disease Models, Animal; Inflammation Media | 2013 |
Pentoxifylline reduces chronic post-ischaemia pain by alleviating microvascular dysfunction.
Topics: Animals; Disease Models, Animal; Ischemia; Male; Microvessels; Pain; Pain Measurement; Pentoxifyllin | 2014 |
Preventive and therapeutic anti-TNF-α therapy with pentoxifylline decreases arthritis and the associated periodontal co-morbidity in mice.
Topics: Alveolar Bone Loss; Animals; Antigens; Arthritis, Experimental; Arthritis, Rheumatoid; C-Reactive Pr | 2013 |
Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspase 9; Disease Models, Animal; Enzyme Act | 2013 |
The effects of intraperitoneal pentoxifylline treatment in rat pups with hypoxic-ischemic encephalopathy.
Topics: Animals; Animals, Newborn; Brain; Caspase 3; Disease Models, Animal; Female; Gene Expression Regulat | 2013 |
Pentoxifylline therapy attenuates intestinal injury in rat pups with hypoxic ischemic encephalopathy.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Free Radical Scavengers; Hypoxia; Hypoxia | 2014 |
The role of classical and alternative macrophages in the immunopathogenesis of herpes simplex virus-induced inflammation in a mouse model.
Topics: Animals; Behcet Syndrome; Colchicine; Disease Models, Animal; Inflammation; Interferon-gamma; Interl | 2014 |
Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1.
Topics: Alprostadil; Animals; Disease Models, Animal; Intestinal Mucosa; Intestine, Small; Ischemia; Male; P | 2013 |
Potential cerebroprotective role of pentoxifyllin in preventing the detrimental cerebral consequences of intra-abdominal hypertension.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebrovascular Circulation; Craniocerebral Trauma; Disea | 2014 |
Pentoxifylline alleviates cardiac ischemia and dysfunction following experimental angina in insulin resistance.
Topics: Adiponectin; Administration, Oral; Angina Pectoris; Animals; Diet; Disease Models, Animal; Electroca | 2014 |
The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Electric Stimulation; Ischemia; Male; Pentoxi | 2014 |
Pentoxifylline attenuates leukocyte-endothelial interactions in a two-hit model of shock and sepsis.
Topics: Animals; Cecum; Cell Communication; Disease Models, Animal; Endothelial Cells; Free Radical Scavenge | 2015 |
Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Drug Evaluation, Precli | 2014 |
Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Depression; Disease Mod | 2014 |
Modulation of radiation-induced oral mucositis by pentoxifylline: preclinical studies.
Topics: Animals; Disease Models, Animal; Dose Fractionation, Radiation; Female; Male; Mice; Mice, Inbred C3H | 2015 |
Efficacy of pentoxifylline and tadalafil in rat model of ischemic colitis.
Topics: Animals; Carbolines; Colitis, Ischemic; Colon; Disease Models, Animal; Female; Laparotomy; Malondial | 2014 |
Stereological comparison of the effects of pentoxifylline, captopril, simvastatin, and tamoxifen on kidney and bladder structure after partial urethral obstruction in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disease Models, Animal; Estrogen Antag | 2014 |
Pentoxifylline alleviates hypertension in metabolic syndrome: effect on low-grade inflammation and angiotensin system.
Topics: Angiotensin II; Animals; Disease Models, Animal; Hypertension; Inflammation; Male; Metabolic Syndrom | 2015 |
The effects of vardenafil and pentoxifylline administration in an animal model of ischemic colitis.
Topics: Animals; Colitis, Ischemic; Colon; Disease Models, Animal; Female; Hemodynamics; Imidazoles; Malondi | 2014 |
Pentoxifylline and prostaglandin E1 action on ischemia and reperfusion of small intestine tissue in rats. An immunohistochemical study.
Topics: Alprostadil; Animals; Apoptosis; Disease Models, Animal; Immunohistochemistry; Intestinal Mucosa; In | 2015 |
A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide.
Topics: Animals; Cobalt Radioisotopes; Cricetinae; Cytokines; Disease Models, Animal; Guanidines; Head and N | 2015 |
Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats.
Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gonadotropins, Pituitary; Male; | 2015 |
Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Capillary Permeability; Disease Models, | 2015 |
Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
Topics: Anaplastic Lymphoma Kinase; Animals; Cytokines; Disease Models, Animal; Gene Expression; Glomerulone | 2015 |
Local hypoxia in oral mucosa (mouse) during daily fractionated irradiation - Effect of pentoxifylline.
Topics: Analysis of Variance; Animals; Cell Count; Demulcents; Disease Models, Animal; Dose Fractionation, R | 2015 |
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; G | 2015 |
An evaluation of the effect of pentoxifylline on blood pressure and myocardial oxidative status following intake of western diet.
Topics: Animals; Antioxidants; Blood Pressure; Diet, Western; Disease Models, Animal; Free Radical Scavenger | 2015 |
The effect of pentoxifylline on detrusor muscle contractility after partial urethral obstruction in a rat model.
Topics: Animals; Disease Models, Animal; Male; Muscle Contraction; Pentoxifylline; Rats; Rats, Sprague-Dawle | 2015 |
Pentoxifylline and electromagnetic field improved bone fracture healing in rats.
Topics: Animals; Disease Models, Animal; Electromagnetic Fields; Femoral Fractures; Fracture Healing; Inject | 2015 |
Pentoxifylline Prevents Driamycin-Induced Myocardial Fibrosis and Apoptosis in Rats.
Topics: Animals; Antineoplastic Agents; Cardiomyopathies; Cardiotonic Agents; Caspase 3; Disease Models, Ani | 2015 |
Development of PEGylated solid lipid nanoparticles of pentoxifylline for their beneficial pharmacological potential in pathological cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Lipids; Male; Nanoparticles; Pentoxifylline; Polyethy | 2016 |
The comparative efficacy of tyloxapol versus pentoxifylline against induced acute phase response in an ovine experimental endotoxemia model.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relat | 2016 |
Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart Ventricles; Male; Oxidative Stress; Pento | 2016 |
Microemulsion for topical application of pentoxifylline: In vitro release and in vivo evaluation.
Topics: Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Liberati | 2016 |
Resolution acute respiratory distress syndrome through reversing the imbalance of Treg/Th17 by targeting the cAMP signaling pathway.
Topics: Animals; Cyclic AMP; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Gene Express | 2016 |
Pentoxifylline Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Cytokines; Disease Models, Animal; Ganglia, Spinal; Hype | 2016 |
Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Inflammation; Mal | 2016 |
Oral Administration of Pentoxifylline Reduces Endometriosis-Like Lesions in a Nude Mouse Model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Endometriosis; Endometrium; Female; Mice; Mic | 2017 |
Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Graft Survival; Heparin; | 2016 |
Early inflammatory changes in radiation-induced oral mucositis : Effect of pentoxifylline in a mouse model.
Topics: Animals; Disease Models, Animal; Dose Fractionation, Radiation; Inflammation Mediators; Mice; Mice, | 2017 |
Pentoxifylline attenuates mucosal damage in an experimental model of rat colitis by modulating tissue biomarkers of inflammation, oxidative stress, and fibrosis.
Topics: Animals; Biomarkers; Colitis; Disease Models, Animal; Female; Fibrosis; Inflammation; Intestinal Muc | 2017 |
Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome.
Topics: Animals; Bone and Bones; Complex Regional Pain Syndromes; Cytokines; Disease Models, Animal; Foot; F | 2009 |
Clarithromycin, montelukast, and pentoxifylline combination treatment ameliorates experimental neonatal hyperoxic lung injury.
Topics: Acetates; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Bronchopulmonary Dyspl | 2008 |
Pentoxifylline attenuates pulmonary inflammation and neutrophil activation in experimental acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Chemokine CXCL1; Disease Models, Animal; | 2008 |
Preservation of peritoneal morphology and function by pentoxifylline in a rat model of peritoneal dialysis: molecular studies.
Topics: Animals; Base Sequence; Cells, Cultured; Collagen Type I; Cytokines; Dialysis Solutions; Disease Mod | 2008 |
Suppression of experimental autoimmune myasthenia gravis by combination therapy: pentoxifylline as a steroid-sparing agent.
Topics: Animals; Antibodies; Body Weight; Cytokines; Disease Models, Animal; Dose-Response Relationship, Dru | 2008 |
Pentoxifylline inhibits transforming growth factor-beta signaling and renal fibrosis in experimental crescentic glomerulonephritis in rats.
Topics: Animals; Disease Models, Animal; Fibrosis; Glomerulonephritis; Kidney; Male; Models, Biological; Pen | 2009 |
Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Edema; Female; Humans; Iloprost; Male; M | 2008 |
Effects of pentoxifylline and n-acetylcysteine on injuries caused by ischemia and reperfusion of splanchnic organs in rats.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Free Radical Scavengers; Hemodynamics; Intestinal M | 2008 |
Inhibition of tubulointerstitial fibrosis by pentoxifylline is associated with improvement of vascular endothelial growth factor expression.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Fibrosis; Humans; Hypoxia-Inducible Factor | 2009 |
Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.
Topics: Angiostatins; Animals; Common Bile Duct; Disease Models, Animal; Endostatins; Hepatopulmonary Syndro | 2009 |
Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endometriosis; Endometrium; Female; Infert | 2010 |
Cilostazol and pentoxifylline decrease angiogenesis, inflammation, and fibrosis in sponge-induced intraperitoneal adhesion in mice.
Topics: Animals; Cilostazol; Disease Models, Animal; Fibrosis; Inflammation; Male; Mice; Mice, Inbred BALB C | 2009 |
Urodilatin and pentoxifylline prevent the early onset of Escherichia coli-induced acute renal failure in a model of isolated perfused rat kidney.
Topics: Acute Kidney Injury; Animals; Atrial Natriuretic Factor; Disease Models, Animal; Escherichia coli In | 2009 |
Re-protective effects of pre- and post-laparoscopy conditioning, zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the kidney.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Kidney; Laparoscopy; Male; Pentoxifylline; Pneumope | 2009 |
Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain.
Topics: Analgesics; Animals; Astrocytes; Biomarkers; Citrates; Complement C1q; Disease Models, Animal; Glial | 2009 |
Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain.
Topics: Amino Acids; Analysis of Variance; Animals; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heteroc | 2009 |
Pentoxifylline in ischemia-induced acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Cell Respiration; Disease Models, Animal; Free Radical Scavengers; Isc | 2009 |
Combination therapy with albumin and pentoxifylline protects against acute kidney injury during endotoxemic shock in mice.
Topics: Acute Kidney Injury; Albumins; Animals; Disease Models, Animal; Drug Therapy, Combination; Male; Mic | 2009 |
Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction-an experimental study in growing animals.
Topics: Animals; Biliary Atresia; Biliary Tract Diseases; Cholestasis; Common Bile Duct Diseases; Disease Mo | 2009 |
Effects of pentoxifylline on inflammation and lung dysfunction in ventilated septic animals.
Topics: Acute Disease; Analysis of Variance; Animals; Bronchoalveolar Lavage; Disease Models, Animal; Enzyme | 2010 |
Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Response | 2009 |
Protective effects of pentoxifylline on the brain following remote burn injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Brain; Burns; Cytokines; Disease Models, A | 2010 |
A novel fluid resuscitation strategy modulates pulmonary transcription factor activation in a murine model of hemorrhagic shock.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inflammation Mediators; Lung; Male; NF-ka | 2010 |
Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction.
Topics: Animals; Collagen; Disease Models, Animal; Erectile Dysfunction; Ganglia, Autonomic; Male; Muscle, S | 2011 |
Protective effects of pentoxifylline on cigarette smoking-induced renal tissue damage in rats.
Topics: Animals; Apoptosis; Disease Models, Animal; In Situ Nick-End Labeling; Kidney; Kidney Diseases; Kidn | 2011 |
Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Disease Models, Animal; Free Radical Scavengers; Infarc | 2011 |
Pentoxifylline and melatonin in combination with pioglitazone ameliorate experimental non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Body Weight; C | 2011 |
The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis.
Topics: Animals; Colitis; Collagen Type I; Colon; Disease Models, Animal; Female; Fibrosis; Inflammation; In | 2011 |
Pretreatment with pentoxifylline has antidepressant-like effects in a rat model of acute myocardial infarction.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Choice Behavior; Depressive Disorder; Disease Mode | 2011 |
Protective effect of pentoxyfilline in renal toxicity after methotrexate administration.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Blood Urea Nitrogen; Creatin | 2011 |
Protective effects of zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the small intestine.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Free Radical Scavengers; Intestine, Small; Laparosc | 2011 |
Effect of pentoxifylline and vinpocetine on the healing of ischemic colon anastomosis: an experimental study.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Colon; Disease Models, Animal; Female; Ischemia; M | 2011 |
Effect of pentoxifylline on histopathological changes in steroid-induced osteonecrosis of femoral head: experimental study in chicken.
Topics: Adipogenesis; Animals; Bone Marrow Cells; Chickens; Disease Models, Animal; Femur Head; Femur Head N | 2012 |
Pretreatment with pentoxifylline and N-acetylcysteine in liver ischemia reperfusion-induced renal injury.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Disease Models, Animal; Dose-Response Relationship, Dr | 2012 |
Current applications of oogram methodology in experimental schistosomiasis; fecundity of female Schistosoma mansoni and egg release in the intestine of AKR/J mice following immunomodulatory treatment with pentoxifylline.
Topics: Animals; Disease Models, Animal; Female; Fertility; Immunologic Factors; Injections, Subcutaneous; I | 2013 |
The effectiveness of hypertonic saline and pentoxifylline (HTS-PTX) resuscitation in haemorrhagic shock and sepsis tissue injury: comparison with LR, HES, and LR-PTX treatments.
Topics: Animals; Disease Models, Animal; Hydroxyethyl Starch Derivatives; Interleukin-6; Isotonic Solutions; | 2012 |
The effects of pentoxifylline on lung inflammation in a rat model of meconium aspiration syndrome.
Topics: Animals; Arteries; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Infant, Newborn; Lu | 2012 |
Fully biodegradable and cationic poly(amino oxalate) particles for the treatment of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Acute Disease; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytosol; D | 2012 |
Phosphodiesterase inhibitor improves renal tubulointerstitial hypoxia of the diabetic rat kidney.
Topics: Animals; Cell Line; Cobalt; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, | 2012 |
Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction in growing animals: immunohistochemical analysis of the expression of TGF-β and VEGF.
Topics: Animals; Cholestasis; Disease Models, Animal; Glucocorticoids; Immunohistochemistry; Liver; Liver Ci | 2012 |
A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury.
Topics: Age Factors; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Burns; Disease Models, | 2013 |
Effect of dexamethasone and pentoxifylline in combination with amoxicillin in the treatment of penicillin-insensitive pneumococcal pneumonia in guinea pigs.
Topics: Amoxicillin; Animals; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Drug-Related | 2002 |
The effects of pentoxifylline on bacterial translocation after intestinal obstruction.
Topics: Analysis of Variance; Animals; Bacterial Infections; Bacterial Translocation; Chi-Square Distributio | 2002 |
Modulation of radiation-induced tumour necrosis factor alpha (TNF-alpha) expression in the lung tissue by pentoxifylline.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Lung; Mice; Mice, | 2002 |
Pro-inflammatory effects of cholera toxin: role of tumor necrosis factor alpha.
Topics: Animals; Cell Movement; Cholera Toxin; Dexamethasone; Disease Models, Animal; Dose-Response Relation | 2002 |
Allopurinol plus pentoxifilline in hepatic ischaemia/reperfusion injury.
Topics: Allopurinol; Animals; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Ischemia | 2002 |
In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-obstructed rats: assessment by tissue collagen content and prolidase activity.
Topics: Animals; Cholestasis; Collagen; Dipeptidases; Disease Models, Animal; Drug Therapy, Combination; Fem | 2003 |
Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis.
Topics: Acute Disease; Animals; Cicatrix; Disease Models, Animal; Escherichia coli; Escherichia coli Infecti | 2003 |
Differential modulation of hippocampal chemical-induced injury response by ebselen, pentoxifylline, and TNFalpha-, IL-1alpha-, and IL-6-neutralizing antibodies.
Topics: Animals; Antibodies; Azoles; Brain Injuries; Cerebellum; Cytokines; Disease Models, Animal; Drug Com | 2003 |
Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; E | 2003 |
Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits.
Topics: Acute Kidney Injury; Animals; Apoptosis; Base Sequence; Cisplatin; Disease Models, Animal; Female; G | 2003 |
Pentoxifylline suppresses renal tumour necrosis factor-alpha and ameliorates experimental crescentic glomerulonephritis in rats.
Topics: Animals; Disease Models, Animal; DNA Primers; Glomerulonephritis; Macrophages; Male; Pentoxifylline; | 2004 |
Circulating TNF-alpha and its soluble receptors during experimental acute pancreatitis.
Topics: Acute Disease; Animals; Disease Models, Animal; Male; Pancreatitis; Pentoxifylline; Rats; Rats, Wist | 2004 |
Pentoxifylline prevents spontaneous brain ischemia in stroke-prone rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Inflammation; Male; Pentoxifylline; Proteinuria; Ra | 2004 |
Gastroprotection by pentoxyfilline against stress-induced gastric damage. Role of lipid peroxidation, antioxidizing enzymes and proinflammatory cytokines.
Topics: Animals; Arginine; Cytokines; Disease Models, Animal; Free Radical Scavengers; Gastric Mucosa; Gluta | 2004 |
Resuscitation affects microcirculatory polymorphonuclear leukocyte behavior after hemorrhagic shock: role of hypertonic saline and pentoxifylline.
Topics: Animals; Disease Models, Animal; Male; Microcirculation; Neutrophils; Pentoxifylline; Rats; Rats, Wi | 2004 |
Pentoxyphilline as a cyclooxygenase (cox-2) inhibitor in experimental sepsis.
Topics: Animals; Antigens, CD; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dis | 2004 |
[The influence of pentoxifylline on the course of experimental peritonitis].
Topics: Animals; Disease Models, Animal; Male; Pentoxifylline; Peritonitis; Phosphodiesterase Inhibitors; Ra | 2004 |
The effects of pentoxifylline on diabetic renal changes in streptozotocin-induced diabetes mellitus.
Topics: Animals; Biopsy, Needle; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, An | 2004 |
Role of type II pneumocytes in pathogenesis of radiation pneumonitis: dose response of radiation-induced lung changes in the transient high vascular permeability period.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Dexamethasone; Disease Models, Animal; Do | 2004 |
Pentoxifylline inhibits endotoxin-induced NF-kappa B activation and associated production of proinflammatory cytokines.
Topics: Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 2004 |
Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome?
Topics: Animals; Disease Models, Animal; Immunologic Factors; Mice; Multiple Organ Failure; Pentoxifylline; | 2005 |
Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters.
Topics: Abscess; Animals; Antimetabolites, Antineoplastic; Cricetinae; Disease Models, Animal; Edema; Erythe | 2005 |
Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome.
Topics: Angioplasty, Balloon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 12-Lipoxygenase | 2006 |
Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cognition Disorders; Discrimination Learning; Disea | 2005 |
Apoptosis detected in the amygdala following myocardial infarction in the rat.
Topics: Amygdala; Animals; Apoptosis; Cerebellum; Cytokines; Depressive Disorder, Major; Disease Models, Ani | 2006 |
Therapeutic administration of Y-40138, a multiple cytokine modulator, inhibits concanavalin A-induced hepatitis in mice.
Topics: Acetamides; Alanine Transaminase; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Chemo | 2005 |
Green tea extract and its major polyphenol (-)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy.
Topics: Animals; Antioxidants; Camellia sinensis; Catechin; Diet; Disease Models, Animal; Free Radical Scave | 2006 |
Radioprotectant combinations spare radiation-induced damage to the physis more than fractionation alone.
Topics: Amifostine; Animals; Anti-Ulcer Agents; Bone Development; Disease Models, Animal; Dose Fractionation | 2005 |
Long-term effect of pentoxifylline and NG-nitro-L-arginine methyl ester on testicular function in spermatic artery ligation.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Immunohistochemistry; Ligation; Male; NG-Nitroargin | 2006 |
HSPTX protects against hemorrhagic shock resuscitation-induced tissue injury: an attractive alternative to Ringer's lactate.
Topics: Animals; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Hematologic Agents; Ileu | 2006 |
LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression.
Topics: Animals; Disease Models, Animal; Endotoxemia; Escherichia coli Infections; Intercellular Adhesion Mo | 2006 |
Pentoxifylline fails to attenuate fibrosis in dystrophic (mdx) diaphragm muscle.
Topics: Animals; Collagen Type I; Collagen Type III; Diaphragm; Disease Models, Animal; Enzyme Inhibitors; F | 2006 |
Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver In | 2006 |
The effect of pentoxifylline in treatment of skin degloving injuries: an experimental study.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Necrosis; Pentoxifylline; Pilot | 2006 |
Pentoxifylline decreases up-regulated nuclear factor kappa B activation and cytokine production in the rat retina following transient ischemia.
Topics: Animals; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Free Radical Scavenge | 2006 |
Pentoxifylline reduces the incidence and severity of necrotizing enterocolitis in a neonatal rat model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enterocolitis, Necrotizing; Free Radical Scavenge | 2006 |
Effects of Iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Iloprost; Kidney; Kidney Cortex; | 2006 |
Pentoxifylline protects against endotoxin-induced acute renal failure in mice.
Topics: Acute Kidney Injury; Alprostadil; Animals; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Down-Regu | 2006 |
Pentoxifylline attenuates the development of hyperalgesia in a rat model of neuropathic pain.
Topics: Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Hyper | 2007 |
Effect of pentoxifylline on lung inflammation and gas exchange in a sepsis-induced acute lung injury model.
Topics: Acute Disease; Animals; Disease Models, Animal; Escherichia coli Infections; Inflammation; Inflammat | 2006 |
Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents.
Topics: Animals; Benzyl Compounds; Blood-Brain Barrier; Dexamethasone; Dimethyl Sulfoxide; Disease Models, A | 2007 |
In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury.
Topics: Animals; Catheterization; Cell Communication; Disease Models, Animal; Endothelial Cells; Leukocyte R | 2007 |
Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain.
Topics: Animals; Disease Models, Animal; Drug Synergism; Hyperalgesia; Male; Mice; Minocycline; Morphine; Ne | 2007 |
Post-ischemic treatment of pentoxifylline reduces cortical not striatal infarct volume in transient model of focal cerebral ischemia in rat.
Topics: Animals; Blood Pressure; Brain Infarction; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; | 2007 |
Pharmacodynamics of pentoxifylline and/or praziquantel in murine schistosomiasis mansoni.
Topics: Animals; Anthelmintics; Disease Models, Animal; Granuloma; Male; Mice; Pentoxifylline; Praziquantel; | 2007 |
Amelioration of steatohepatitis with pentoxifylline in a novel nonalcoholic steatohepatitis model induced by high-fat diet.
Topics: Animals; Dietary Fats; Disease Models, Animal; Disease Progression; Fatty Liver; Follow-Up Studies; | 2007 |
[Experimental treatment of acute lung injury caused by inundation of thoracic cavity by seawater following open chest wound].
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dogs; Female; Imme | 2007 |
Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Chemokines; Diarrhea; Disease Models, Anim | 2008 |
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Coculture Techniq | 2007 |
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.
Topics: Alanine Transaminase; Animals; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Diseas | 2007 |
Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock.
Topics: Animals; Anti-Inflammatory Agents; Chemokine CXCL1; Disease Models, Animal; Heme Oxygenase-1; Isoton | 2007 |
Pentoxifylline ameliorates lithium-pilocarpine induced status epilepticus in young rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dopamine; Dose-Response Relatio | 2008 |
The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Nervous System Diseases; Pain; Pentoxifylline; | 2008 |
Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery.
Topics: Animals; Apoptosis; Chronic Disease; Disease Models, Animal; Endarterectomy; Endothelial Cells; Free | 2008 |
Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats.
Topics: Action Potentials; Animals; Cervical Vertebrae; Diaphragm; Disease Models, Animal; Electromyography; | 2008 |
Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure.
Topics: Action Potentials; Adrenocorticotropic Hormone; Angiotensin II; Animals; Anti-Inflammatory Agents; C | 2008 |
Cardioprotective actions of pentoxifylline in an animal model of acute myocardial ischaemia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cathepsin D; Cathepsins; Cats; Coronary Disease; Creatine Kin | 1984 |
[Pharmacological protection of the kidneys from ischemic damage. The effectiveness of anti-ischemia protection of the kidneys in simulating the terminal state in the donors].
Topics: Animals; Death; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Humans; Hypotension; Isc | 1982 |
[Experimental study on the effect of pentoxifylline on blood rheology and microcirculation--a study using an endotoxin shock model].
Topics: Animals; Blood Flow Velocity; Blood Viscosity; Disease Models, Animal; Microcirculation; Pentoxifyll | 1983 |
Pentoxifylline does not protect mice against hypoxia.
Topics: Animals; Cerebrovascular Circulation; Disease Models, Animal; Energy Metabolism; Hypoxia; Mice; Mice | 1981 |
Pentoxifylline attenuates pulmonary macromolecular leakage after intestinal ischemia-reperfusion.
Topics: Animals; Blood-Air Barrier; Cardiac Output; Disease Models, Animal; Hemodynamics; Intestines; Ischem | 1995 |
Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats.
Topics: Animals; Arthritis; Autoimmune Diseases; Cecal Diseases; Disease Models, Animal; Humans; Immunoglobu | 1995 |
Beneficial effects of the phosphodiesterase inhibitors BRL 61063, pentoxifylline, and rolipram in a murine model of endotoxin shock.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, | 1994 |
Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats.
Topics: Abdomen; Animals; Cecal Diseases; Disease Models, Animal; Endothelins; Endotoxins; Interleukin-6; In | 1995 |
Pentoxifylline modulates cytokine responses in a sepsis model.
Topics: Animals; Antibodies; Blood Pressure; Cytokines; Disease Models, Animal; Endotoxins; Female; Interleu | 1994 |
Failure of pentoxifylline to ameliorate severe acute pancreatitis in the rat: results of a prospective, randomized, controlled study.
Topics: Acute Disease; Analysis of Variance; Animals; Ceruletide; Chi-Square Distribution; Disease Models, A | 1994 |
Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis.
Topics: Animals; Bacteremia; Cecum; Cell Movement; Disease Models, Animal; Interleukin-1; Ligation; Macropha | 1994 |
Pentoxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine model of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Cells, Cultured; Disease Models, Animal; Male; Meclofen | 1994 |
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Cyclic Nuc | 1993 |
Effects of pentoxifylline on in vivo leukocyte function and clearance of group B streptococci from preterm rabbit lungs.
Topics: Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid; Colony Count, Microbial; Disease Models, An | 1993 |
Correlation of function and energy metabolism in rat ischemic skeletal muscle by 31P-NMR spectroscopy: effects of torbafylline.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Hydrogen-Ion Concentration; Ischemia; Magneti | 1993 |
Influence of pentoxifylline and albifylline on liver microcirculation and leukocyte adhesion after hemorrhagic shock in the rat.
Topics: Animals; Cell Adhesion Molecules; Disease Models, Animal; Female; Liver Circulation; Pentoxifylline; | 1996 |
Analysis of responses to pentoxifylline in the pulmonary vascular bed of the cat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arginine | 1996 |
Modulation of TNF alpha and IL-6 in a peritonitis model using pentoxifylline.
Topics: Animals; Blood Pressure; Cecum; Disease Models, Animal; Female; Interleukin-6; Intestinal Perforatio | 1996 |
Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Ducts; Cell Division; Collagen; Dis | 1996 |
A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach.
Topics: Animals; Anti-Ulcer Agents; Antibodies, Monoclonal; CD18 Antigens; Disease Models, Animal; Gastric A | 1996 |
Pentoxifylline, a drug with rheological effects, decreases portal pressure in an experimental model of cirrhosis.
Topics: Animals; Blood Viscosity; Cardiac Output; Cholestasis; Disease Models, Animal; Double-Blind Method; | 1997 |
The effects of post-treatment with lisofylline, a phosphatidic acid generation inhibitor, on sepsis-induced acute lung injury in pigs.
Topics: Adjuvants, Immunologic; Animals; Disease Models, Animal; Female; Hemodynamics; Lung; Male; Pentoxify | 1997 |
Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissue lipid peroxidation in a rat model.
Topics: Animals; Disease Models, Animal; Lipid Peroxidation; Male; Malondialdehyde; Penile Erection; Penis; | 1997 |
Listeria monocytogenes infection in mice treated with pentoxifylline.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Hypersensitivity, Delayed; Listeriosis; Ma | 1997 |
Pentoxifylline inhibits overflow and reduces intestinal reperfusion injury.
Topics: Animals; Disease Models, Animal; Intestinal Mucosa; Intestine, Small; Male; Malondialdehyde; Pentoxi | 1997 |
Effect of acute pentoxifylline treatment in an experimental model of colitis.
Topics: Animals; Colitis; Collagen; Colon; Disease Models, Animal; Male; Pentoxifylline; Phosphodiesterase I | 1997 |
Local production of oxygen free radicals and nitric oxide in rat diaphragm during sepsis: effects of pentoxifylline and somatostatin.
Topics: Analysis of Variance; Animals; Biomarkers; Confidence Intervals; Diaphragm; Disease Models, Animal; | 1997 |
Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
Effects of pentoxifylline infusion on response of horses to in vivo challenge exposure with endotoxin.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Blood Pressure; Body Temperature; Disea | 1997 |
[The effect of some drugs on the levels of selected cytokines in experimental septic shock].
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dexamethasone; Disease Models, Animal; Ibuprofen; Live | 1997 |
Pentoxifylline preserves intestinal function (and more) following shock.
Topics: Animals; Disease Models, Animal; Intestines; Pentoxifylline; Phosphodiesterase Inhibitors; Resuscita | 1998 |
Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shock.
Topics: 3-Hydroxybutyric Acid; Acyl-CoA Dehydrogenase; Animal Feed; Animals; Disease Models, Animal; Fatty A | 1998 |
Effect of human recombinant tumour necrosis factor-alpha and pentoxifylline on the ultrastructure of type II alveolar epithelial cells in pregnant and non-pregnant rabbits.
Topics: Animals; Disease Models, Animal; Epithelial Cells; Female; Humans; Microscopy, Electron; Pentoxifyll | 1997 |
[The effect of trental and thiotriazoline on tissue blood flow, oxygen tension and vascular reactivity in the pancreas in acute experimental pancreatitis].
Topics: Acute Disease; Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Hemodynamics; Ox | 1998 |
Increasing doses of pentoxifylline as a continuous infusion in canine septic shock.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Body Temperature; Disease Models, Animal; Dogs | 1999 |
Selective downregulation of neutrophils by a phosphatidic acid generation inhibitor in a porcine sepsis model.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteremia; Cell Adhesion; Disease Models, | 1999 |
Effect of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis.
Topics: Animals; Bacteremia; Critical Care; Cytokines; Dietary Proteins; Disease Models, Animal; Dose-Respon | 1999 |
Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia.
Topics: Animals; Bacteremia; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxins; Escherichia c | 1999 |
Neuroprotection by caffeine and pentoxifylline during experimental cerebral ischaemia.
Topics: Animals; Brain Ischemia; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Disease Model | 1999 |
Effects of acute and repeated dose administration of caffeine and pentoxifylline on diazepam-induced mouse behavior in the hole-board test.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal | 1999 |
Pentoxifylline improves circulatory failure and survival in murine models of endotoxaemia.
Topics: Anesthesia; Animals; Aorta, Thoracic; Blood Circulation; Blood Pressure; Cardiovascular Diseases; Di | 1999 |
Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; Cell Division; Chemokine CCL2; Collagen; Disease Mod | 1999 |
Pentoxifylline inhibits neointimal formation and stimulates constrictive vascular remodeling after arterial injury.
Topics: Animals; Apoptosis; Blood Pressure; Carotid Artery Injuries; Cell Division; Cell Movement; Collagen; | 1999 |
Pentoxifylline fails to improve organ dysfunction and survival when used in the resuscitation of a porcine model of haemorrhage and abdominal sepsis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemodynamics; Hemorrhage; | 2000 |
Effect of vitamin E and pentoxifylline on glycerol-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Creatine Kinase; Creatinine; Disease Models, Animal; Glycerol; Kidney | 2000 |
Inhibition of matrix metalloproteinase activity attenuates tenascin-C production and calcification of implanted purified elastin in rats.
Topics: Alkaline Phosphatase; Animals; Benzyl Compounds; Calcinosis; Dexamethasone; Disease Models, Animal; | 2000 |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
Topics: Animals; Capillaria; Disease Models, Animal; Enoplida Infections; Female; Gadolinium; Liver Cirrhosi | 2000 |
The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Autoimmune Diseases; Bucladesine; Cells, Cultured; | 2001 |
Antimetastatic efficacy of niosomal pentoxifylline and its combination with activated macrophages in murine B16F10 melanoma model.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Combinations; Drug Delivery Systems | 2000 |
Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis.
Topics: Alendronate; Animals; Arthritis; Arthroplasty; Cell Division; Disease Models, Animal; Female; Male; | 2000 |
Enhancement of anti-metastatic activity of pentoxifylline by encapsulation in conventional liposomes and sterically stabilized liposomes in murine experimental B16F10 melanoma model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Female; Liposom | 2000 |
Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Benzyl Compounds; Cell Survival; Dexamethasone; Disease Models, Anim | 2001 |
Pentoxifylline reduces coronary leukocyte accumulation early in reperfusion after cold ischemia.
Topics: Animals; Cardioplegic Solutions; Coronary Vessels; Disease Models, Animal; Heart Arrest, Induced; Le | 2001 |
In vivo downregulation of T helper cell 1 immune responses reduces atherogenesis in apolipoprotein E-knockout mice.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Body Weight; Cell Count; Cell Differentiation; Cells, | 2001 |
The effects of pentoxifylline treatment on bacterial translocation after hemorrhagic shock in rats.
Topics: Animals; Bacterial Infections; Bacterial Translocation; Blood; Blood Transfusion, Autologous; Cecum; | 2001 |
Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits.
Topics: Animals; Antioxidants; Aortic Diseases; Arterial Occlusive Diseases; Biomarkers; Cytokines; Disease | 2002 |
Variation in murid Plasmodium desequestration and its modulation by stress and pentoxifylline.
Topics: Animals; Disease Models, Animal; Hematologic Agents; Malaria; Mice; Parasitemia; Pentoxifylline; Pla | 2002 |
Pentoxifylline improves blood flow to both testes in testicular torsion.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pentoxifylline; Probability | 2002 |
[Evaluation of the antithrombotic effects of pentoxifylline, acetylsalicylic acid and low molecular weight heparin in the laser model of thrombosis].
Topics: Animals; Aspirin; Disease Models, Animal; Heparin, Low-Molecular-Weight; In Vitro Techniques; Lasers | 1992 |
Pentoxifylline modulates deformability, F-actin content, and superoxide anion production of polymorphonuclear leukocytes from diabetic cats.
Topics: Actins; Animals; Anions; Cats; Diabetic Retinopathy; Disease Models, Animal; Neutrophils; Pentoxifyl | 1992 |
Pentoxifylline treatment of sepsis in conscious Yucatan minipigs.
Topics: Animals; Creatine; Disease Models, Animal; Escherichia coli; Hemodynamics; Oxygen; Pentoxifylline; S | 1992 |
Group B streptococcal sepsis in piglets: effect of combined pentoxifylline and indomethacin pretreatment.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Indometh | 1992 |
Xanthine derivative HWA 138 attenuates hemodynamic and oxygen uptake dysfunction secondary to severe endotoxin shock in sheep.
Topics: Animals; Disease Models, Animal; Endotoxins; Escherichia coli; Female; Half-Life; Hemodynamics; Male | 1992 |
Effect of amrinone on tumor necrosis factor production in endotoxic shock.
Topics: Amrinone; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Chromatography; Dexamethasone; Di | 1992 |
Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Dogs; Double-Blind Method; Drug Evaluation, Preclinical; Hemodynami | 1991 |
Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: a paradigm for a novel approach to the treatment of endometriosis-associated subfertility.
Topics: Adjuvants, Immunologic; Animals; Disease Models, Animal; Endometriosis; Female; Fertilization; Infer | 1991 |
Survival factors in a canine septic shock model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Erythrocyte Deformability; Escherichia coli I | 1991 |
Prevention of cyclosporine-induced nephrotoxicity with pentoxifylline.
Topics: Acute Kidney Injury; Animals; Biological Availability; Cyclosporins; Disease Models, Animal; Epopros | 1989 |
Effects of pentoxifylline in experimental acute renal failure.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Glycerol; Hemogl | 1989 |
Modulation of meningeal inflammation by treatment with pentoxifylline.
Topics: Animals; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Meningitis, Haemophilus; | 1989 |
Anti-hypoxic potency of cerebroprotective drugs studied in a model of acute reversible respiratory failure.
Topics: Animals; Brain Ischemia; Cats; Dihydroergotoxine; Disease Models, Animal; Electrocardiography; Hypox | 1989 |
Pentoxifylline does not reduce infarct size in a canine model of acute myocardial infarction.
Topics: Animals; Blood Pressure; Coronary Disease; Coronary Vessels; Disease Models, Animal; Dogs; Heart Rat | 1988 |