pentoxifylline has been researched along with Disease, Pulmonary in 34 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether the administration of lisofylline (1-[5R-hydroxyhexyl]-3,7-dimethylxanthine) would decrease mortality in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS)." | 9.10 | Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. ( , 2002) |
| "Mortality and morbidity due to neonatal sepsis and necrotising enterocolitis (NEC) remain high despite the use of potent antimicrobial agents." | 7.01 | Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates. ( Haque, KN; Pammi, M, 2023) |
| "To determine whether the administration of lisofylline (1-[5R-hydroxyhexyl]-3,7-dimethylxanthine) would decrease mortality in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS)." | 5.10 | Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. ( , 2002) |
| "To evaluate the efficacy of pentoxifylline (PTXF) in the attenuation of lung inflammation during volume-induced lung injury (VILI) in newborn piglets, 17 newborn piglets were mechanically ventilated with a large tidal volume (50 ml/kg) for a period of 8 h." | 3.72 | Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. ( Bancalari, E; Huang, J; Rodriguez, MM; Smalling, WE; Suguihara, C, 2004) |
| "Mortality and morbidity due to neonatal sepsis and necrotising enterocolitis (NEC) remain high despite the use of potent antimicrobial agents." | 3.01 | Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates. ( Haque, KN; Pammi, M, 2023) |
| " We recommend the prophylactic use of Ptx, finding it to be safe and effective." | 2.71 | Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial. ( Atavci, S; Egehan, I; Kitapci, M; Ozturk, B, 2004) |
| "Pentoxifylline has anti-inflammatory properties resulting from inhibition of erythrocyte phosphodiesterase." | 2.46 | Pentoxifylline in preterm neonates: a systematic review. ( Harris, E; Patole, SK; Schulzke, SM, 2010) |
| "Pentoxifylline pretreatment significantly improved the measurements of left lung edema and epithelial and endothelial permeability." | 1.30 | The effects of two antiinflammatory pretreatments on bacterial-induced lung injury. ( Broaddus, VC; Hattori, S; Kravchenko, V; Kudoh, I; Mathison, JC; Miyazaki, H; Nishizawa, H; Pittet, JF; Sawa, T; Wiener-Kronish, JP; Yamada, H; Yamakawa, T, 1999) |
| " A reduction of hemoglobin content was seen after PTXF administration only in animals receiving the lowest dosage of papain." | 1.29 | [The effect of pentoxifylline on the degree of lung parenchyma injury after papain]. ( Dziecioł, J; Nowak, HF; Sulkowska, M; Sulkowski, S, 1993) |
| " Because previous studies suggested a role for pentoxifylline in attenuating the toxic effects of IL-2, we hypothesized that pentoxifylline would inhibit alterations in the microvasculature induced by IL-2 and would ultimately reduce IL-2-induced toxicity." | 1.28 | Pentoxifylline inhibits interleukin-2-induced leukocyte-endothelial adherence and reduces systemic toxicity. ( Abney, DL; Edwards, MJ; Miller, FN, 1991) |
| "coli septicemia plus PTXF bolus 20 mg/kg injected 5 min before E." | 1.27 | Attenuation of acute lung injury in septic guinea pigs by pentoxifylline. ( Harada, H; Hogue, RS; Ishizaka, A; O'Hanley, PT; Raffin, TA; Stephens, KE; Wu, ZH, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.82) | 18.7374 |
| 1990's | 15 (44.12) | 18.2507 |
| 2000's | 13 (38.24) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Pammi, M | 1 |
| Haque, KN | 1 |
| Oliveira-Júnior, IS | 2 |
| Oliveira, IS | 1 |
| Oliveira, WR | 1 |
| Cavassani, SS | 1 |
| Brunialti, MK | 2 |
| Salomao, R | 2 |
| Harris, E | 1 |
| Schulzke, SM | 1 |
| Patole, SK | 1 |
| Patole, S | 1 |
| Vijayakumar, P | 1 |
| Jog, S | 1 |
| Sekerova, V | 1 |
| Subrtova, D | 1 |
| Mrazek, F | 1 |
| Gibejova, A | 1 |
| Kolek, V | 1 |
| du Bois, RM | 1 |
| Petrek, M | 1 |
| Michetti, C | 1 |
| Coimbra, R | 1 |
| Hoyt, DB | 1 |
| Loomis, W | 1 |
| Junger, W | 1 |
| Wolf, P | 1 |
| Ozturk, B | 1 |
| Egehan, I | 1 |
| Atavci, S | 1 |
| Kitapci, M | 1 |
| Mohan, PV | 1 |
| Tarnow-Mordi, W | 1 |
| Stenson, B | 1 |
| Brocklehurst, P | 1 |
| Haque, K | 1 |
| Cavendish, V | 1 |
| Cust, A | 1 |
| Smalling, WE | 1 |
| Suguihara, C | 1 |
| Huang, J | 1 |
| Rodriguez, MM | 1 |
| Bancalari, E | 1 |
| Lauterbach, R | 1 |
| Pawlik, D | 1 |
| Zembala, M | 1 |
| Szymura-Oleksiak, J | 1 |
| Lisowska-Miszczyk, I | 1 |
| Kowalczyk, D | 1 |
| Bury, J | 1 |
| Koh, IH | 1 |
| Junqueira, VB | 1 |
| Misirlioglu, CH | 1 |
| Demirkasimoglu, T | 1 |
| Kucukplakci, B | 1 |
| Sanri, E | 1 |
| Altundag, K | 1 |
| Jellett, L | 1 |
| Harrison, C | 1 |
| McAleese, J | 1 |
| Shen, CY | 1 |
| Hsu, K | 1 |
| Wang, D | 1 |
| Yan, HC | 1 |
| Remiszewski, P | 1 |
| Roszkowski, K | 1 |
| Zabel, P | 2 |
| Ogura, H | 1 |
| Cioffi, WG | 1 |
| Okerberg, CV | 1 |
| Johnson, AA | 1 |
| Guzman, RF | 1 |
| Mason, AD | 1 |
| Pruitt, BA | 1 |
| Sulkowski, S | 2 |
| Nowak, HF | 1 |
| Sulkowska, M | 2 |
| Dziecioł, J | 1 |
| Schlaak, M | 1 |
| George, CL | 1 |
| Fantuzzi, G | 1 |
| Bursten, S | 1 |
| Leer, L | 1 |
| Abraham, E | 1 |
| Miyazaki, H | 1 |
| Broaddus, VC | 1 |
| Wiener-Kronish, JP | 1 |
| Sawa, T | 1 |
| Pittet, JF | 1 |
| Kravchenko, V | 1 |
| Mathison, JC | 1 |
| Nishizawa, H | 1 |
| Hattori, S | 1 |
| Yamakawa, T | 1 |
| Yamada, H | 1 |
| Kudoh, I | 1 |
| Poulakis, N | 1 |
| Androutsos, G | 1 |
| Kazi, D | 1 |
| Bastas, A | 1 |
| Provata, A | 1 |
| Bitsakou, C | 1 |
| Kontozoglou, T | 1 |
| Polyzogopoulou, C | 1 |
| Tassiopoulou, A | 1 |
| Brandolini, L | 1 |
| Asti, C | 1 |
| Ruggieri, V | 1 |
| Intilangelo, A | 1 |
| Pellegrini, L | 1 |
| Chiusaroli, R | 1 |
| Caselli, GF | 1 |
| Bertini, R | 1 |
| Lynch, RE | 1 |
| Yonemaru, M | 3 |
| Hatherill, JR | 3 |
| Hoffmann, H | 3 |
| Zheng, H | 3 |
| Ishii, K | 1 |
| Raffin, TA | 5 |
| Crowley, J | 1 |
| Harada, H | 2 |
| Ishizaka, A | 3 |
| Edwards, MJ | 1 |
| Abney, DL | 1 |
| Miller, FN | 1 |
| Rosenfeld, BA | 1 |
| Toung, TJ | 1 |
| Sendak, MJ | 1 |
| Breslow, MJ | 1 |
| Hutchins, GM | 1 |
| Traystman, RJ | 1 |
| Fujishima, S | 1 |
| Wu, ZH | 1 |
| Stephens, KE | 1 |
| Hogue, RS | 1 |
| O'Hanley, PT | 1 |
| Welsh, CH | 1 |
| Lien, D | 1 |
| Worthen, GS | 1 |
| Weil, JV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)[NCT00000579] | Phase 3 | 0 participants | Interventional | 1994-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for pentoxifylline and Disease, Pulmonary
| Article | Year |
|---|---|
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates.
Topics: Anti-Bacterial Agents; Enterocolitis, Necrotizing; Humans; Immunoglobulin M; Immunoglobulins, Intrav | 2023 |
Pentoxifylline in preterm neonates: a systematic review.
Topics: Animals; Humans; Infant, Newborn; Lung Diseases; Meconium Aspiration Syndrome; Pentoxifylline; Persi | 2010 |
Perinatal immunomodulation.
Topics: Adjuvants, Immunologic; Chronic Disease; Cromolyn Sodium; Female; Glucocorticoids; Hematopoietic Cel | 2002 |
Can polyclonal intravenous immunoglobulin limit cytokine mediated cerebral damage and chronic lung disease in preterm infants?
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Brain Diseases; Chronic Disease; Cytokines; Humans | 2004 |
Pentoxyfylline in and prevention and treatment of chronic lung disease.
Topics: Chronic Disease; Enzyme Inhibitors; Humans; Infant, Newborn; Lung Diseases; Pentoxifylline; Randomiz | 2004 |
[Mechanisms of radiation to the lung. Pentoxifylline--a new radioprotective drug?].
Topics: Animals; Humans; Lung; Lung Diseases; Pentoxifylline; Radiation Injuries, Experimental; Radiation-Pr | 1995 |
[Pathogenesis of interstitial pulmonary changes with collagen diseases--therapeutic implications].
Topics: Adrenal Cortex Hormones; Antigen-Antibody Complex; Antimetabolites; Autoantibodies; Autoantigens; Au | 1995 |
[Tumor necrosis factor alpha in lung diseases].
Topics: Adrenal Cortex Hormones; Humans; Lung Diseases; Pentoxifylline; Pulmonary Alveoli; Tumor Necrosis Fa | 1993 |
3 trials available for pentoxifylline and Disease, Pulmonary
| Article | Year |
|---|---|
Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial.
Topics: Adult; Breast Neoplasms; Female; Humans; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Pentoxify | 2004 |
Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer.
Topics: Adult; Aged; alpha-Tocopherol; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Combined Modal | 2007 |
Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Fatty Acids, Nonesterified; Humans; In | 2002 |
23 other studies available for pentoxifylline and Disease, Pulmonary
| Article | Year |
|---|---|
Effects of pentoxifylline on inflammation and lung dysfunction in ventilated septic animals.
Topics: Acute Disease; Analysis of Variance; Animals; Bronchoalveolar Lavage; Disease Models, Animal; Enzyme | 2010 |
In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases.
Topics: Adult; Aged; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokine CCL5; Chemokines, CC; Cyclospo | 2003 |
Pentoxifylline reduces acute lung injury in chronic endotoxemia.
Topics: Animals; Bronchoalveolar Lavage Fluid; CD11b Antigen; Chronic Disease; Edema; Endotoxemia; Intercell | 2003 |
Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Biomechanical Phenomena; Inflammation; Lung; Lu | 2004 |
Effect of pentoxifylline on lung inflammation and gas exchange in a sepsis-induced acute lung injury model.
Topics: Acute Disease; Animals; Disease Models, Animal; Escherichia coli Infections; Inflammation; Inflammat | 2006 |
Letter to editor. Re: "Effect of concomitant use of pentoxifylline (PTX) and alpha-tocopherol with radiotherapy on the clinical outcome of patients with stage IIIB non-small cell lung cancer".
Topics: alpha-Tocopherol; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Drug Therapy, Combinati | 2007 |
Pentoxifylline attenuates acute lung injury induced by microemboli.
Topics: Acute Disease; Animals; Blood Platelets; Blood Pressure; Bronchoalveolar Lavage Fluid; Calcium Chlor | 1995 |
The effects of pentoxifylline on pulmonary function following smoke inhalation.
Topics: Animals; Blood Pressure; Bronchoalveolar Lavage Fluid; Hemodynamics; Leukocyte Count; Lung Diseases; | 1994 |
[The effect of pentoxifylline on the degree of lung parenchyma injury after papain].
Topics: Animals; Bronchoalveolar Lavage Fluid; Female; Hemoglobins; Leukocyte Count; Lung; Lung Diseases; Ma | 1993 |
Effects of lisofylline on hyperoxia-induced lung injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic AMP Response Element-Binding Protein; Fatty | 1999 |
Effect of pentoxifylline on the development of apoptosis-like changes in experimental lung damage.
Topics: Animals; Apoptosis; Chromatin; Endothelium; Free Radical Scavengers; Lung; Lung Diseases; Male; Micr | 1999 |
The effects of two antiinflammatory pretreatments on bacterial-induced lung injury.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Infections; Goats; Immune Sera; Interleukin-8; Lung Dis | 1999 |
The differential effect of pentoxifylline on cytokine production by alveolar macrophages and its clinical implications.
Topics: Adult; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cytokines; Depression, Chemical; Female; Granu | 1999 |
Lipopolysaccharide-induced lung injury in mice. II. Evaluation of functional damage in isolated parenchyma strips.
Topics: Animals; Anti-Inflammatory Agents; Betamethasone; Bradykinin; Dose-Response Relationship, Drug; Drug | 2000 |
Lisofylline: anti-acute respiratory distress syndrome or just anti-inflammatory?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Lung Diseases; Pentoxifylline; Respiratory Distress | 2002 |
Pentoxifylline does not attenuate acute lung injury in the absence of granulocytes.
Topics: Animals; Blood Pressure; Cells, Cultured; Cyclic AMP; Endothelium, Vascular; Epithelial Cells; Epith | 1991 |
Early post-treatment with pentoxifylline or dibutyryl cAMP attenuates Escherichia coli-induced acute lung injury in guinea pigs.
Topics: Animals; Blood Pressure; Bronchoalveolar Lavage Fluid; Bucladesine; Endotoxins; Escherichia coli; Es | 1991 |
Pentoxifylline inhibits interleukin-2-induced leukocyte-endothelial adherence and reduces systemic toxicity.
Topics: Animals; Cell Adhesion; Endothelium, Vascular; Hyperventilation; Hypotension; Hypoxia; Interleukin-2 | 1991 |
Pentoxifylline attenuates edema formation in proteolytic enzyme-induced lung injury.
Topics: Airway Resistance; Animals; Capillary Permeability; Chymotrypsin; Dogs; Drug Evaluation, Preclinical | 1990 |
Acute lung injury and pentoxifylline.
Topics: Humans; Lung Diseases; Neutrophils; Pentoxifylline | 1990 |
Attenuation of acute lung injury in septic guinea-pigs by a new xanthine derivative (HWA-138).
Topics: Acute Disease; Animals; Blood Pressure; Bronchodilator Agents; Erythrocytes; Escherichia coli Infect | 1989 |
Attenuation of acute lung injury in septic guinea pigs by pentoxifylline.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Escherichia coli Infections; Female; Glucuroni | 1988 |
Pentoxifylline decreases endotoxin-induced pulmonary neutrophil sequestration and extravascular protein accumulation in the dog.
Topics: Animals; Blood Proteins; Capillary Permeability; Dogs; Endotoxins; Hemodynamics; Kidney; Lung; Lung | 1988 |