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pentoxifylline and Chronic Kidney Diseases

pentoxifylline has been researched along with Chronic Kidney Diseases in 21 studies

Research Excerpts

ExcerptRelevanceReference
"Pentoxifylline (PTX) is a promising therapeutic approach for reducing inflammation and improving anemia associated to various systemic disorders."8.91Pentoxifylline for Anemia in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. ( Bolignano, D; Coppolino, G; D'Arrigo, G; Pisano, A, 2015)
"The aim of this study was to assess the effect of pentoxifylline on proteinuria and renal function in chronic kidney disease (CKD) treatment."4.93Effect of pentoxifylline in proteinuric chronic kidney disease: a systematic review and meta-analysis. ( Cui, M; Jiang, X; Kong, X; Yao, J; Zhou, S, 2016)
"Pentoxifylline (PTX) is a promising therapeutic approach for reducing inflammation and improving anemia associated to various systemic disorders."4.91Pentoxifylline for Anemia in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. ( Bolignano, D; Coppolino, G; D'Arrigo, G; Pisano, A, 2015)
"Pentoxifylline treatment (400 mg/twice a day) or standard treatment."2.90Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial. ( Barbieri, D; Carbayo, J; de Jose, AP; de Morales, AM; Delgado, A; Goicoechea, M; Luño, J; Verdalles, U; Verde, E, 2019)
"Pentoxifylline has been shown to increase haemoglobin levels in patients with chronic kidney disease (CKD) and erythropoietin-stimulating agent (ESA)-hyporesponsive anaemia in the Handling Erythropoietin Resistance with Oxpentifylline multicentre double-blind, randomized controlled trial."2.84Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial. ( Badve, SV; Cass, A; Clarke, P; Ferrari, P; Gummer, J; Hawley, CM; Johnson, DW; McDonald, SP; Morrish, AT; Olynyk, JK; Pascoe, EM; Pedagogos, E; Perkovic, V; Reidlinger, D; Scaria, A; Trengove, R; Vergara, LA; Walker, R, 2017)
" CTP-499 was well tolerated with no serious or severe adverse events, or adverse events leading to discontinuation."2.82A First-in-Patient, Multicenter, Double-Blind, 2-Arm, Placebo-Controlled, Randomized Safety and Tolerability Study of a Novel Oral Drug Candidate, CTP-499, in Chronic Kidney Disease. ( Braman, V; Cheng, C; Dao, M; Graham, P; Liu, J; Neutel, J; Sabounjian, L; Shipley, J; Wu, L, 2016)
"Patients with chronic kidney diseases (CKD) are often treated with antiplatelets due to aberrant haemostasis."1.62The risk of major bleeding event in patients with chronic kidney disease on pentoxifylline treatment. ( Chen, JY; Chen, YC; Fang, JH; Ho, CH; Hsing, CH; Liang, FW; Wu, CC, 2021)
"In terms of the risks of developing ESRD, pentoxifylline alone exerted a comparable beneficial effect to combined therapy with an RAAS inhibitor and greater renoprotection than RAAS inhibitor monotherapy."1.42Pentoxifylline Decreases Dialysis Risk in Patients With Advanced Chronic Kidney Disease. ( Chen, CY; Chen, L; Chen, YM; Huang, TM; Lin, CJ; Lin, SL; Pan, CF; Wu, CH; Wu, CJ; Wu, PC; Wu, VC, 2015)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's20 (95.24)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Yang, H1
Juang, SY1
Liao, KF1
Chen, YH1
Fang, JH1
Chen, YC1
Ho, CH1
Chen, JY1
Hsing, CH1
Liang, FW1
Wu, CC1
Chen, YM3
Chiang, WC3
Lin, SL2
Tsai, TJ2
Navarro-González, JF1
Sánchez-Niño, MD1
Donate-Correa, J1
Martín-Núñez, E1
Ferri, C1
Pérez-Delgado, N1
Górriz, JL1
Martínez-Castelao, A1
Ortiz, A1
Mora-Fernández, C1
de Morales, AM1
Goicoechea, M1
Verde, E1
Carbayo, J1
Barbieri, D1
Delgado, A1
Verdalles, U1
de Jose, AP1
Luño, J1
Murkamilov, IT1
Aitbaev, KA1
Fomin, VV1
Murkamilova, ZA1
Bayzhigitova, AA1
Mettang, T1
Kremer, AE1
Chen, PM2
Lai, TS2
Chen, PY2
Lai, CF1
Wu, V1
Wu, KD1
Kao, CC1
Wu, MS1
Antunes, SA1
Vilela, RQ1
Vaz, JD1
Canziani, ME1
Johnson, DW2
Pascoe, EM2
Badve, SV2
Dalziel, K1
Cass, A2
Clarke, P2
Ferrari, P2
McDonald, SP2
Morrish, AT2
Pedagogos, E2
Perkovic, V2
Reidlinger, D2
Scaria, A2
Walker, R2
Vergara, LA2
Hawley, CM2
He, T1
Cooper, ME1
Wu, PC1
Wu, CJ1
Lin, CJ1
Pan, CF1
Chen, CY1
Huang, TM1
Wu, CH1
Chen, L1
Wu, VC1
Bolignano, D2
D'Arrigo, G1
Pisano, A2
Coppolino, G2
Jiang, X1
Zhou, S1
Yao, J1
Kong, X1
Cui, M1
Kuo, KL1
Hung, SC1
Liu, JS1
Chang, YK1
Hsu, CC1
Tarng, DC1
Leporini, C1
Russo, E1
D Arrigo, G1
de Sarro, G1
Gummer, J1
Trengove, R1
Olynyk, JK1
Sabounjian, L1
Graham, P1
Wu, L1
Braman, V1
Cheng, C1
Liu, J1
Shipley, J1
Neutel, J1
Dao, M1
Pena-Polanco, JE1
Fried, LF1

Reviews

7 reviews available for pentoxifylline and Chronic Kidney Diseases

ArticleYear
Therapeutic efficacy of pentoxifylline on proteinuria and renal progression: an update.
    Journal of biomedical science, 2017, Nov-13, Volume: 24, Issue:1

    Topics: Disease Progression; Kidney Failure, Chronic; Pentoxifylline; Phosphodiesterase Inhibitors; Proteinu

2017
Pentoxifylline and nephroprotection: effects on renal dysfunction and cardiovascular risks.
    Terapevticheskii arkhiv, 2019, Mar-11, Volume: 91, Issue:1

    Topics: Cardiovascular Diseases; Disease Progression; Humans; Kidney; Pentoxifylline; Renal Insufficiency, C

2019
Uremic pruritus.
    Kidney international, 2015, Volume: 87, Issue:4

    Topics: Acupuncture Therapy; Amines; Anti-Inflammatory Agents; Calcium Channel Blockers; Cyclohexanecarboxyl

2015
Pentoxifylline for Anemia in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Adult; Anemia; Anti-Inflammatory Agents; Female; Humans; Male; Pentoxifylline; Phosphodiesterase Inh

2015
Effect of pentoxifylline in proteinuric chronic kidney disease: a systematic review and meta-analysis.
    Journal of nephrology, 2016, Volume: 29, Issue:5

    Topics: Chi-Square Distribution; Glomerular Filtration Rate; Humans; Kidney; Odds Ratio; Pentoxifylline; Pho

2016
Effect of pentoxifylline on renal outcomes in chronic kidney disease patients: A systematic review and meta-analysis.
    Pharmacological research, 2016, Volume: 107

    Topics: Humans; Kidney; Pentoxifylline; Proteinuria; Randomized Controlled Trials as Topic; Renal Insufficie

2016
Established and Emerging Strategies in the Treatment of Chronic Kidney Disease.
    Seminars in nephrology, 2016, Volume: 36, Issue:4

    Topics: Allopurinol; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bicarbonate

2016

Trials

6 trials available for pentoxifylline and Chronic Kidney Diseases

ArticleYear
Effects of Pentoxifylline on Soluble Klotho Concentrations and Renal Tubular Cell Expression in Diabetic Kidney Disease.
    Diabetes care, 2018, Volume: 41, Issue:8

    Topics: Adult; Aged; Albuminuria; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Nephropathie

2018
Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial.
    Journal of nephrology, 2019, Volume: 32, Issue:4

    Topics: Aged; Aged, 80 and over; Albuminuria; Cardiovascular Diseases; Creatinine; Disease Progression; Foll

2019
Pentoxifylline does not alter the concentration of hepcidin in chronic kidney disease patients undergoing hemodialysis.
    The International journal of artificial organs, 2014, Jul-31, Volume: 37, Issue:7

    Topics: Adult; Aged; Anemia; Anti-Inflammatory Agents; Combined Modality Therapy; Female; Ferritins; Hemoglo

2014
A randomized, placebo-controlled trial of pentoxifylline on erythropoiesis-stimulating agent hyporesponsiveness in anemic patients with CKD: the Handling Erythropoietin Resistance With Oxpentifylline (HERO) trial.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015, Volume: 65, Issue:1

    Topics: Adult; Aged; Anemia; Cost Savings; Double-Blind Method; Drug Monitoring; Drug Resistance; Drug Syner

2015
Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial.
    Nephrology (Carlton, Vic.), 2017, Volume: 22, Issue:7

    Topics: Aged; Aged, 80 and over; Anemia; Biomarkers; Darbepoetin alfa; Double-Blind Method; Drug Resistance;

2017
A First-in-Patient, Multicenter, Double-Blind, 2-Arm, Placebo-Controlled, Randomized Safety and Tolerability Study of a Novel Oral Drug Candidate, CTP-499, in Chronic Kidney Disease.
    Clinical pharmacology in drug development, 2016, Volume: 5, Issue:4

    Topics: Administration, Oral; Aged; Aged, 80 and over; Biomarkers; Diabetes Mellitus, Type 2; Double-Blind M

2016

Other Studies

8 other studies available for pentoxifylline and Chronic Kidney Diseases

ArticleYear
Comparing the Effect of Folic Acid and Pentoxifylline on Delaying Dialysis Initiation in Patients with Advanced Chronic Kidney Disease.
    Nutrients, 2019, Sep-12, Volume: 11, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Disease Progression; Female; Folic Acid;

2019
The risk of major bleeding event in patients with chronic kidney disease on pentoxifylline treatment.
    Scientific reports, 2021, 06-29, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Databases, Factual; Female; Gastrointestinal Hemorrhage; Humans; Intracrani

2021
Renoprotective effect of combining pentoxifylline with angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker in advanced chronic kidney disease.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2014, Volume: 113, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhi

2014
Reply to comment on "Renoprotective effect of combining pentoxifylline with angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker in advanced chronic kidney disease".
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2015, Volume: 114, Issue:1

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Kidney;

2015
Renoprotective effect of pentoxifylline in advanced chronic kidney disease.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2015, Volume: 114, Issue:1

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Diabetic Nephropathies;

2015
Diabetic nephropathy: renoprotective effects of pentoxifylline in the PREDIAN trial.
    Nature reviews. Nephrology, 2014, Volume: 10, Issue:10

    Topics: Aged; Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Free Radi

2014
Pentoxifylline Decreases Dialysis Risk in Patients With Advanced Chronic Kidney Disease.
    Clinical pharmacology and therapeutics, 2015, Volume: 98, Issue:4

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biomarkers;

2015
Add-on Protective Effect of Pentoxifylline in Advanced Chronic Kidney Disease Treated with Renin-Angiotensin-Aldosterone System Blockade - A Nationwide Database Analysis.
    Scientific reports, 2015, Nov-27, Volume: 5

    Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Creatinine; Databases, Fac

2015