pentoxifylline has been researched along with Chemical and Drug Induced Liver Injury in 22 studies
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, to clarify the role of activated macrophages in the augmentation of endotoxin hepatoxicity, rats were pretreated with zymosan, an activator of macrophages, before the induction of endotoxin hepatotoxicity, and some were given pentoxifylline, an inhibitor of tumour necrosis factor production." | 3.69 | Role of activated macrophages in augmentation of endotoxin hepatotoxicity. ( Asaka, S; Nakata, K; Shibayama, Y, 1994) |
| "Glycogen loss was observed in the hepatocytes localized at the periphery of lobule." | 1.43 | The effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in rats. ( Ates, B; Esrefoglu, M; Taskapan, C; Taslidere, E; Vardi, N; Yologlu, S, 2016) |
| "Pentoxifylline (PTX) is a non-selective phosphodiesterase inhibitor with the effects of antioxidation, anti-inflammation and anti-fibrosis that has been shown to induce damage in liver." | 1.42 | Protective effects of pentoxifylline on acute liver injury induced by thioacetamide in rats. ( Dong, L; Li, J; Luo, M; Shang, B; Wang, Y, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 10 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Mohamed, DI | 1 |
| Elmelegy, AA | 1 |
| El-Aziz, LF | 1 |
| Abdel Kawy, HS | 1 |
| AbdEl-Samad, AA | 1 |
| El-Kharashi, OA | 1 |
| Armagan, I | 1 |
| Bayram, D | 1 |
| Candan, IA | 1 |
| Yigit, A | 1 |
| Celik, E | 1 |
| Armagan, HH | 1 |
| Uğuz, AC | 1 |
| Taslidere, E | 1 |
| Vardi, N | 1 |
| Esrefoglu, M | 1 |
| Ates, B | 1 |
| Taskapan, C | 1 |
| Yologlu, S | 1 |
| Luo, M | 1 |
| Dong, L | 1 |
| Li, J | 1 |
| Wang, Y | 1 |
| Shang, B | 1 |
| Kim, H | 1 |
| Kim, Y | 1 |
| Guk, K | 1 |
| Yoo, D | 1 |
| Lim, H | 1 |
| Kang, G | 1 |
| Lee, D | 1 |
| Copple, BL | 1 |
| Ganey, PE | 4 |
| Roth, RA | 4 |
| He, Q | 1 |
| Sharma, RP | 1 |
| Fukuda, T | 1 |
| Mogami, A | 1 |
| Hisadome, M | 1 |
| Komatsu, H | 1 |
| Noyan, T | 1 |
| Kömüroğlu, U | 1 |
| Bayram, I | 1 |
| Sekeroğlu, MR | 1 |
| Tukov, FF | 1 |
| Luyendyk, JP | 1 |
| Shaw, PJ | 1 |
| Hopfensperger, MJ | 1 |
| Hewett, JA | 1 |
| Shibayama, Y | 1 |
| Asaka, S | 1 |
| Nakata, K | 1 |
| Sáez-Royuela, F | 1 |
| López-Vázquez, A | 1 |
| López-Morante, A | 1 |
| Díez-Sánchez, V | 1 |
| Martín-Lorente, JL | 1 |
| Gunther, R | 1 |
| Chelstrom, LM | 1 |
| Wendorf, HR | 1 |
| Schneider, EA | 1 |
| Covalciuc, K | 1 |
| Johnson, B | 1 |
| Clementson, D | 1 |
| Irvin, JD | 1 |
| Myers, DE | 1 |
| Uckun, FM | 1 |
| Okamoto, T | 1 |
| Sneed, RA | 1 |
| Buchweitz, JP | 1 |
| Jean, PA | 1 |
1 review available for pentoxifylline and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
21 other studies available for pentoxifylline and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Hepatoprotective effects of early pentoxifylline administration on hepatic injury induced by concanavalin A in rat.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liv | 2014 |
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; G | 2015 |
The effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in rats.
Topics: Animals; Caffeic Acids; Caspase 3; Chemical and Drug Induced Liver Injury; Galactosamine; Glycogen; | 2016 |
Protective effects of pentoxifylline on acute liver injury induced by thioacetamide in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Glutathione; Liver; Male; Malondialdehyd | 2015 |
Fully biodegradable and cationic poly(amino oxalate) particles for the treatment of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Acute Disease; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cytosol; D | 2012 |
Liver inflammation during monocrotaline hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Chemokine | 2003 |
Inhibition of tumor necrosis factor alpha signaling by anti-tumor necrosis factor alpha antibodies and pentoxifylline is unable to prevent fumonisin hepatotoxicity in mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antibodies; Apoptosis; Aspartate Aminotransfera | 2005 |
Therapeutic administration of Y-40138, a multiple cytokine modulator, inhibits concanavalin A-induced hepatitis in mice.
Topics: Acetamides; Alanine Transaminase; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Chemo | 2005 |
Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver In | 2006 |
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Coculture Techniq | 2007 |
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.
Topics: Alanine Transaminase; Animals; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Diseas | 2007 |
The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria.
Topics: Ancrod; Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Dose-Response Relationsh | 1995 |
Role of activated macrophages in augmentation of endotoxin hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Liver Diseases; Macrophage Activation; | 1994 |
Pentoxifylline-induced acute hepatitis.
Topics: Acute Disease; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Humans; Pent | 1995 |
Toxicity profile of the investigational new biotherapeutic agent, B43 (anti-CD19)-pokeweed antiviral protein immunotoxin.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antigens, CD19; Antineoplastic Agents, Ph | 1996 |
Pentoxifylline inhibits anti-Fas antibody-induced hepatitis by affecting downstream of CPP32-like activity in mice.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspases; Chemical and Drug Induced Liver Inj | 1999 |
Pentoxifylline attenuates bacterial lipopolysaccharide-induced enhancement of allyl alcohol hepatotoxicity.
Topics: Alanine Transaminase; Animals; Antibodies, Blocking; Cells, Cultured; Chemical and Drug Induced Live | 2000 |