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pentoxifylline and Cardiomegaly

pentoxifylline has been researched along with Cardiomegaly in 7 studies

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
" Moreover, we put in light a TNF-α-independent beneficial effect of pentoxifylline in the VEETKO mice suggesting a therapeutic potential for pentoxifylline in a subpopulation of heart failure patients at higher risk."3.80Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice. ( Emoto, N; Heiden, S; Masuda, S; Nakayama, K; Vignon-Zellweger, N; Yagi, K; Yanagisawa, M, 2014)
"These findings suggest that in chronic cardiac hypertrophy, contractile responses to phosphodiesterase inhibitors may be preserved despite marked reductions in inotropic responses to beta-adrenoceptor agonists."1.33Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats. ( Norton, G; Osadchii, O; Woodiwiss, A, 2005)
" As chronic administration of a beta-adrenoreceptor (beta-AR) agonist mediates the premature onset of cardiac remodeling without myocyte necrosis or myocardial dysfunction in LVH, we suggest that beta-AR activation is critical in promoting the transition from compensated LVH to cardiac dilatation."1.33Phosphodiesterase inhibition promotes the transition from compensated hypertrophy to cardiac dilatation in rats. ( Anamourlis, C; Badenhorst, D; Correia, R; Gibbs, M; Norton, GR; Osadchii, O; Veliotes, D; Woodiwiss, AJ, 2006)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heiden, S1
Vignon-Zellweger, N1
Masuda, S1
Yagi, K1
Nakayama, K1
Yanagisawa, M1
Emoto, N1
Song, XA1
Jia, LL1
Cui, W1
Zhang, M1
Chen, W1
Yuan, ZY1
Guo, J1
Li, HH1
Zhu, GQ1
Liu, H1
Kang, YM1
Zhang, X1
Meng, F1
Song, J1
Zhang, L1
Wang, J1
Li, D1
Li, L1
Dong, P1
Yang, B1
Chen, Y1
Dhiman, S1
Mishra, N1
Sharma, S1
Osadchii, O2
Norton, G1
Woodiwiss, A1
Anamourlis, C1
Badenhorst, D1
Gibbs, M1
Correia, R1
Veliotes, D1
Norton, GR1
Woodiwiss, AJ1
Heublein, B1
Franz, N1
Modersohn, D1
Linss, G1
Lange, T1
Specht, FK1
Heublein-Balint, EG1

Other Studies

7 other studies available for pentoxifylline and Cardiomegaly

ArticleYear
Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Aorta; Apoptosis; Blood Pressure; Cardiomegaly; Echocardiography; Endothelin-1; Endothelium

2014
Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats.
    Toxicology and applied pharmacology, 2014, 11-15, Volume: 281, Issue:1

    Topics: Animals; Cardiomegaly; Hypertension; Male; Neurotransmitter Agents; Paraventricular Hypothalamic Nuc

2014
Pentoxifylline Ameliorates Cardiac Fibrosis, Pathological Hypertrophy, and Cardiac Dysfunction in Angiotensin II-induced Hypertensive Rats.
    Journal of cardiovascular pharmacology, 2016, Volume: 67, Issue:1

    Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Hypertension; Inflammation Mediators; Male; Pentoxi

2016
Development of PEGylated solid lipid nanoparticles of pentoxifylline for their beneficial pharmacological potential in pathological cardiac hypertrophy.
    Artificial cells, nanomedicine, and biotechnology, 2016, Volume: 44, Issue:8

    Topics: Animals; Cardiomegaly; Disease Models, Animal; Lipids; Male; Nanoparticles; Pentoxifylline; Polyethy

2016
Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats.
    European journal of pharmacology, 2005, May-09, Volume: 514, Issue:2-3

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amrinone; Animals; Blood Pressure; Cardiomegaly; Cardiotonic

2005
Phosphodiesterase inhibition promotes the transition from compensated hypertrophy to cardiac dilatation in rats.
    Pflugers Archiv : European journal of physiology, 2006, Volume: 451, Issue:4

    Topics: Animals; Blood Pressure; Cardiomegaly; Collagen; Cyclic AMP; Heart; Myocardial Contraction; Organ Si

2006
[Effects of pentoxifylline on diastolic heart function in patients with angina pectoris and an increased left ventricular wall mass].
    Herz, 1988, Volume: 13, Issue:2

    Topics: Adult; Angina Pectoris; Cardiomegaly; Diastole; Female; Heart Ventricles; Hemodynamics; Humans; Info

1988