Page last updated: 2024-11-02

pentoxifylline and Breast Cancer

pentoxifylline has been researched along with Breast Cancer in 26 studies

Research Excerpts

ExcerptRelevanceReference
"To conduct a randomized clinical trial to determine whether the combination of pentoxifylline (PTX) and vitamin E given for 6 months after breast/chest wall irradiation effectively prevents radiation-induced fibrosis (RIF)."9.17Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter. ( Bhatia, S; Bodeker, K; Buatti, J; Button, AM; Jacobson, G; Smith, BJ, 2013)
" Women with breast cancer were treated for 12 months with 400 mg pentoxifylline t."9.14Pentoxifylline and vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer: a phase two, double-blind, placebo-controlled randomised clinical trial (Ptx-5). ( Höglund, P; Johansson, K; Jönsson, C; Killander, F; Kjellén, E; Magnusson, M; Malmström, P; Weddig, A, 2009)
" A number of studies testing alpha-tocopherol (vitamin E) and pentoxifylline suggest evidence of clinical regression of superficial radiation-induced fibrosis but there is only very limited evidence from randomised trials."9.11Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer. ( Cornes, P; Earl, J; Gothard, L; Hall, E; MacLaren, J; Mortimer, P; Peacock, J; Peckitt, C; Woods, M; Yarnold, J, 2004)
" This study was conducted to determine whether oral and intravenous (IV) PTX and Cipro permits increased dose levels of oral busulfan (BU) with a fixed dose of IV cyclophosphamide (CY) in patients with breast cancer receiving autologous or syngeneic hematopoetic cell transplantation."9.11Dose escalation of busulfan with pentoxifylline and ciprofloxacin in patients with breast cancer undergoing autologous transplants. ( Bensinger, WI; Buckner, CD; Holmberg, L; Lilleby, K; Slattery, JT; Storb, R, 2004)
"Intrinsic estrogenicities of the selective estrogen receptor modulators (SERMs) toremifene 60 mg daily or 200 mg daily and tamoxifen 20 mg daily (TOR60, TOR200 and TAM20) were compared in a randomized clinical study in postmenopausal women with advanced breast cancer."9.10Estrogenic effects of toremifene and tamoxifen in postmenopausal breast cancer patients. ( Ellmén, J; Hakulinen, P; Hayes, DF; Partanen, A, 2003)
"The data indicate a beneficial therapeutic effect of pentoxifylline and vitamin E on radiation-induced fibrosis."8.79[The treatment of cutaneous radiation-induced fibrosis with pentoxifylline and vitamin E. An empirical report]. ( Gottlöber, P; Korting, HC; Krähn, G; Peter, RU; Stock, W, 1996)
" As per the reports, the choice of drug in the treatment of breast cancer is paclitaxel, but the major limitation is its toxicity."7.77Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells. ( Goel, PN; Gude, RP, 2011)
"Radiation-induced fibrosis is a side effect of radiation therapy and may occur in up to 13% of the cases in patients (Radiother Oncol, 2009;90:80), fortunately usually is modest/localized and not associated with marked symptoms."6.58Pentoxifylline and vitamin E for treatment or prevention of radiation-induced fibrosis in patients with breast cancer. ( Jones, EL; Kaidar-Person, O; Marks, LB, 2018)
"Pentoxifylline (PTX) is a methylxanthine derivative that improves blood flow by decreasing its viscosity."5.40Pentoxifylline regulates the cellular adhesion and its allied receptors to extracellular matrix components in breast cancer cells. ( Goel, PN; Gude, RP, 2014)
"Pentoxifylline (PTX) is a methylxanthine derivative currently being used in the treatment of peripheral vascular diseases."5.39Curbing the focal adhesion kinase and its associated signaling events by pentoxifylline in MDA-MB-231 human breast cancer cells. ( Goel, PN; Gude, RP, 2013)
"To conduct a randomized clinical trial to determine whether the combination of pentoxifylline (PTX) and vitamin E given for 6 months after breast/chest wall irradiation effectively prevents radiation-induced fibrosis (RIF)."5.17Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter. ( Bhatia, S; Bodeker, K; Buatti, J; Button, AM; Jacobson, G; Smith, BJ, 2013)
" Women with breast cancer were treated for 12 months with 400 mg pentoxifylline t."5.14Pentoxifylline and vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer: a phase two, double-blind, placebo-controlled randomised clinical trial (Ptx-5). ( Höglund, P; Johansson, K; Jönsson, C; Killander, F; Kjellén, E; Magnusson, M; Malmström, P; Weddig, A, 2009)
" A number of studies testing alpha-tocopherol (vitamin E) and pentoxifylline suggest evidence of clinical regression of superficial radiation-induced fibrosis but there is only very limited evidence from randomised trials."5.11Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer. ( Cornes, P; Earl, J; Gothard, L; Hall, E; MacLaren, J; Mortimer, P; Peacock, J; Peckitt, C; Woods, M; Yarnold, J, 2004)
" This study was conducted to determine whether oral and intravenous (IV) PTX and Cipro permits increased dose levels of oral busulfan (BU) with a fixed dose of IV cyclophosphamide (CY) in patients with breast cancer receiving autologous or syngeneic hematopoetic cell transplantation."5.11Dose escalation of busulfan with pentoxifylline and ciprofloxacin in patients with breast cancer undergoing autologous transplants. ( Bensinger, WI; Buckner, CD; Holmberg, L; Lilleby, K; Slattery, JT; Storb, R, 2004)
"Intrinsic estrogenicities of the selective estrogen receptor modulators (SERMs) toremifene 60 mg daily or 200 mg daily and tamoxifen 20 mg daily (TOR60, TOR200 and TAM20) were compared in a randomized clinical study in postmenopausal women with advanced breast cancer."5.10Estrogenic effects of toremifene and tamoxifen in postmenopausal breast cancer patients. ( Ellmén, J; Hakulinen, P; Hayes, DF; Partanen, A, 2003)
"The data indicate a beneficial therapeutic effect of pentoxifylline and vitamin E on radiation-induced fibrosis."4.79[The treatment of cutaneous radiation-induced fibrosis with pentoxifylline and vitamin E. An empirical report]. ( Gottlöber, P; Korting, HC; Krähn, G; Peter, RU; Stock, W, 1996)
" As per the reports, the choice of drug in the treatment of breast cancer is paclitaxel, but the major limitation is its toxicity."3.77Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells. ( Goel, PN; Gude, RP, 2011)
" We recommend the prophylactic use of Ptx, finding it to be safe and effective."2.71Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial. ( Atavci, S; Egehan, I; Kitapci, M; Ozturk, B, 2004)
"Radiation-induced fibrosis is a side effect of radiation therapy and may occur in up to 13% of the cases in patients (Radiother Oncol, 2009;90:80), fortunately usually is modest/localized and not associated with marked symptoms."2.58Pentoxifylline and vitamin E for treatment or prevention of radiation-induced fibrosis in patients with breast cancer. ( Jones, EL; Kaidar-Person, O; Marks, LB, 2018)
"Breast cancer was the most predominant neoplasm (70."1.91Pentoxifylline and tocopherol as prophylaxis for osteonecrosis of the jaw due to bone-modifying agents in patients with cancer submitted to tooth extraction: a case series. ( da Motta Silveira, FM; de Andrade Veras, SR; de Lima E Silva, DF; de Mello, MJG; Magalhães, JMI; Regueira, LS, 2023)
"Pentoxifylline (PTX) is a methylxanthine derivative that improves blood flow by decreasing its viscosity."1.40Pentoxifylline regulates the cellular adhesion and its allied receptors to extracellular matrix components in breast cancer cells. ( Goel, PN; Gude, RP, 2014)
"Pentoxifylline (PTX) is a methylxanthine derivative currently being used in the treatment of peripheral vascular diseases."1.39Curbing the focal adhesion kinase and its associated signaling events by pentoxifylline in MDA-MB-231 human breast cancer cells. ( Goel, PN; Gude, RP, 2013)
"The diagnosis was made as right breast cancer (T4c, N3c, M1, and stage IV)."1.35[A case of stage IV breast cancer responding to S-1 therapy after FEC and PTX therapies]. ( Aoyagi, H; Hamada, S; Kaneko, J; Katsuta, E; Maejima, S; Makinose, T; Okubo, K; Saguchi, M; Sato, T; Sekine, T; Someno, Y; Sugihara, K, 2009)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (23.08)18.2507
2000's10 (38.46)29.6817
2010's9 (34.62)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Magalhães, JMI1
da Motta Silveira, FM1
Regueira, LS1
de Lima E Silva, DF1
de Andrade Veras, SR1
de Mello, MJG1
Kaidar-Person, O1
Marks, LB1
Jones, EL1
Goel, PN3
Gude, RP3
Nidhyanandan, S1
Boreddy, TS1
Chandrasekhar, KB1
Reddy, ND1
Kulkarni, NM1
Narayanan, S1
Cook, M1
Johnson, N1
Zegzula, HD1
Schray, M1
Glissmeyer, M1
Sorenson, L1
Magnusson, M1
Höglund, P1
Johansson, K1
Jönsson, C1
Killander, F1
Malmström, P1
Weddig, A1
Kjellén, E1
Aoyagi, H1
Kaneko, J1
Makinose, T1
Someno, Y1
Katsuta, E1
Saguchi, M1
Okubo, K1
Hamada, S1
Sekine, T1
Sato, T1
Sugihara, K1
Maejima, S1
Shoma, A1
Eldars, W1
Noman, N1
Saad, M1
Elzahaf, E1
Abdalla, M1
Eldin, DS1
Zayed, D1
Shalaby, A1
Malek, HA1
Szabolcsi, O1
Nagy-Toldi, A1
Zeher, M1
Végh, J1
Jacobson, G1
Bhatia, S1
Smith, BJ1
Button, AM1
Bodeker, K1
Buatti, J1
Delanian, S4
Porcher, R2
Balla-Mekias, S2
Lefaix, JL4
Ellmén, J1
Hakulinen, P1
Partanen, A1
Hayes, DF1
Ozturk, B1
Egehan, I1
Atavci, S1
Kitapci, M1
Gothard, L1
Cornes, P1
Earl, J1
Hall, E1
MacLaren, J1
Mortimer, P1
Peacock, J1
Peckitt, C1
Woods, M1
Yarnold, J1
Bensinger, WI1
Buckner, CD1
Lilleby, K1
Holmberg, L1
Storb, R1
Slattery, JT1
Anscher, MS1
Rudant, J1
Fan, S1
Smith, ML1
Rivet, DJ1
Duba, D1
Zhan, Q1
Kohn, KW1
Fornace, AJ1
O'Connor, PM1
Stewart, DJ1
Evans, WK1
Logan, D1
Gottlöber, P1
Krähn, G1
Korting, HC1
Stock, W1
Peter, RU1
Steeves, RA1
Robins, HI1
Dezube, BJ1
Fridovich-Keil, JL1
Bouvard, I1
Lange, RF1
Pardee, AB1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients[NCT05637216]Phase 240 participants (Anticipated)Interventional2023-08-17Recruiting
Evaluation of the Medical Benefit of a Spa Therapy on the Evolutionary Genius of Late Sequelae Fibrosis After Postoperative Radiotherapy for Breast Cancer in Remission[NCT05874492]110 participants (Anticipated)Interventional2023-09-30Not yet recruiting
Development of Radiation Fibrosis in Patients Treated With Pentoxyphylline and Vitamin E: a Prospective Randomized Study[NCT00583700]Phase 254 participants (Actual)Interventional2003-02-28Completed
Multicenter Prospective Evaluation of a Predictive Test of Late Toxicities After Radiotherapy by the Rate of Radiation Induced CD8 T-Lymphocyte Apoptosis: Application to Breast and Prostate Cancers.[NCT00893035]885 participants (Actual)Observational2006-06-30Completed
Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy[NCT00969111]70 participants (Anticipated)Interventional2009-08-31Recruiting
An Expanded Phase II Study of Hypofractionated Dose Intense Image Guided Proton Radiation Therapy for Low and Intermediate Risk Adenocarcinoma of the Prostate[NCT01368055]361 participants (Actual)Interventional2011-09-30Active, not recruiting
Double-Blind, Placebo-Controlled, Randomised Trial Of Alpha-Tocopherol And Oxpentifylline In Patients With Radiation Fibrosis[NCT00022204]Phase 20 participants Interventional2000-01-31Completed
Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment[NCT03040778]Phase 3100 participants (Anticipated)Interventional2018-04-01Enrolling by invitation
Normal Tissue Oxygenation Following Radiotherapy[NCT00677040]20 participants (Actual)Observational2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Subjective, Objective, Management, and Analytic (SOMA) Score

A primary outcome of interest is the composite Subjective, Objective, Management, and Analytic (SOMA) score at 18-month follow-up visit. Maximum score is 45, with a score of 0 being ideal and representing no treatment-related side effects at the study visit. (NCT00583700)
Timeframe: 18 month post-treatment

Interventionunits on a scale (Mean)
Control Arm1.59
Intervention: Pentoxifylline & Vitamin E1.0

Tissue Compliance

"Tissue compliance meter measurements of the treated breast compared to the non-treated breast were obtained at 18 months post-radiation therapy. Tissue compliance simply means how soft and pliable the breast tissue is when force is applied to it.~One physician would hold the tissue compliance meter (TCM) against the participant's skin. A standard amount of force would be applied. A second physician would read the displacement scale for a specific set of areas on the breast. The range of the scale was 0 to 60 milimeters (mm). The physician's were blineded to the participant's intervention at the time of measurement.~The final value is the difference between the untreated and the treated breast [untreated - treated]. The range of these differences was -3.3 to 7.0 mm." (NCT00583700)
Timeframe: 18 months post-treatment

Interventionmilimeters (mm) (Mean)
Control Arm2.10
Intervention: Pentoxifylline & Vitamin E0.88

Tissue Oxygenation

Transcutaneous oxygen detector is used to measure the partial pressure of oxygen. The unit detects electrolytes ionized by oxygen. The measuring electrode also heats the skin being measured to facilitate maximal bloodflow to the area. (NCT00677040)
Timeframe: One visit for 20 minutes

InterventionmmHg (Mean)
Subjects62.5

Skin and Soft Tissue Toxicity Will be Assessed Using the RTOG/EORTC Late Radiation Morbidity Scoring Schema When Oxygenation is Measured.

(NCT00677040)
Timeframe: One visit

InterventionParticipants (Count of Participants)
late subcutaneous toxicitiy score 1late subcutaneous toxcity score 2late skin toxicity score 1late skin toxicity score 2
Subjects191191

Reviews

2 reviews available for pentoxifylline and Breast Cancer

ArticleYear
Pentoxifylline and vitamin E for treatment or prevention of radiation-induced fibrosis in patients with breast cancer.
    The breast journal, 2018, Volume: 24, Issue:5

    Topics: Breast Neoplasms; Female; Fibrosis; Humans; Pentoxifylline; Radiation Injuries; Radiation-Protective

2018
[The treatment of cutaneous radiation-induced fibrosis with pentoxifylline and vitamin E. An empirical report].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1996, Volume: 172, Issue:1

    Topics: Breast Neoplasms; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Therapy, Combination; Fe

1996

Trials

9 trials available for pentoxifylline and Breast Cancer

ArticleYear
Pentoxifylline and vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer: a phase two, double-blind, placebo-controlled randomised clinical trial (Ptx-5).
    European journal of cancer (Oxford, England : 1990), 2009, Volume: 45, Issue:14

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Drug Therapy, Combination; Female; Humans

2009
Pentoxifylline and local honey for radiation-induced burn following breast conservative surgery.
    Current clinical pharmacology, 2010, Volume: 5, Issue:4

    Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Honey; Humans; Mastectomy, Segment

2010
Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter.
    International journal of radiation oncology, biology, physics, 2013, Mar-01, Volume: 85, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Compliance; Drug Therapy, Combination; Fem

2013
Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter.
    International journal of radiation oncology, biology, physics, 2013, Mar-01, Volume: 85, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Compliance; Drug Therapy, Combination; Fem

2013
Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter.
    International journal of radiation oncology, biology, physics, 2013, Mar-01, Volume: 85, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Compliance; Drug Therapy, Combination; Fem

2013
Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter.
    International journal of radiation oncology, biology, physics, 2013, Mar-01, Volume: 85, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Compliance; Drug Therapy, Combination; Fem

2013
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-01, Volume: 21, Issue:13

    Topics: Aged; Antioxidants; Breast Neoplasms; Double-Blind Method; Female; Humans; Middle Aged; Pentoxifylli

2003
Estrogenic effects of toremifene and tamoxifen in postmenopausal breast cancer patients.
    Breast cancer research and treatment, 2003, Volume: 82, Issue:2

    Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Antithrombin

2003
Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial.
    International journal of radiation oncology, biology, physics, 2004, Jan-01, Volume: 58, Issue:1

    Topics: Adult; Breast Neoplasms; Female; Humans; Lung Diseases; Lung Neoplasms; Male; Middle Aged; Pentoxify

2004
Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 73, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chronic Disease; Combined Modality Therapy; Confid

2004
Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 73, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chronic Disease; Combined Modality Therapy; Confid

2004
Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 73, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chronic Disease; Combined Modality Therapy; Confid

2004
Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 73, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chronic Disease; Combined Modality Therapy; Confid

2004
Dose escalation of busulfan with pentoxifylline and ciprofloxacin in patients with breast cancer undergoing autologous transplants.
    Oncology, 2004, Volume: 67, Issue:5-6

    Topics: Adult; Anti-Infective Agents; Bone Marrow Transplantation; Breast Neoplasms; Busulfan; Ciprofloxacin

2004
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005
Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combina

2005

Other Studies

15 other studies available for pentoxifylline and Breast Cancer

ArticleYear
Pentoxifylline and tocopherol as prophylaxis for osteonecrosis of the jaw due to bone-modifying agents in patients with cancer submitted to tooth extraction: a case series.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023, Jul-12, Volume: 31, Issue:8

    Topics: Adolescent; Adult; Aged; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservati

2023
Curbing the focal adhesion kinase and its associated signaling events by pentoxifylline in MDA-MB-231 human breast cancer cells.
    European journal of pharmacology, 2013, Aug-15, Volume: 714, Issue:1-3

    Topics: Animals; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Fe

2013
Pentoxifylline regulates the cellular adhesion and its allied receptors to extracellular matrix components in breast cancer cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Chick Embryo; Chickens; Chorioallantoic

2014
Phosphodiesterase inhibitor, pentoxifylline enhances anticancer activity of histone deacetylase inhibitor, MS-275 in human breast cancer in vitro and in vivo.
    European journal of pharmacology, 2015, Oct-05, Volume: 764

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzami

2015
Prophylactic use of pentoxifylline (Trental) and vitamin E to prevent capsular contracture after implant reconstruction in patients requiring adjuvant radiation.
    American journal of surgery, 2016, Volume: 211, Issue:5

    Topics: Adult; Breast Implantation; Breast Implants; Breast Neoplasms; Cohort Studies; Drug Therapy, Combina

2016
[A case of stage IV breast cancer responding to S-1 therapy after FEC and PTX therapies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined C

2009
Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells.
    Molecular and cellular biochemistry, 2011, Volume: 358, Issue:1-2

    Topics: Acridine Orange; Apoptosis; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Move

2011
[Systemic sclerosis in a patient suffering from breast cancer].
    Magyar onkologia, 2012, Volume: 56, Issue:1

    Topics: Adult; Amlodipine; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Duct

2012
The irreversibility of radiation-induced fibrosis: fact or folklore?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Antioxidants; Brachytherapy; Breast Neoplasms; Drug Therapy, Combination; Female; Humans; Pentoxifyl

2005
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
    Cancer research, 1995, Apr-15, Volume: 55, Issue:8

    Topics: Apoptosis; Breast Neoplasms; Cell Line; Cell Survival; Cisplatin; Clone Cells; Doxorubicin; Etoposid

1995
Addition of pentoxifylline plus nifedipine to chemotherapy in patients with cisplatin-resistant cancers of the lung and other sites.
    American journal of clinical oncology, 1994, Volume: 17, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Drug Evaluation; Drug R

1994
Pentoxifylline treatment of radiation mastitis.
    International journal of radiation oncology, biology, physics, 1998, Dec-01, Volume: 42, Issue:5

    Topics: Breast Neoplasms; Female; Humans; Mastitis; Pentoxifylline; Radiation-Protective Agents; Radiodermat

1998
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10

    Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; M

1999
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10

    Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; M

1999
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10

    Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; M

1999
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:10

    Topics: Adult; Aged; Breast Neoplasms; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; M

1999
Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate.
    The British journal of radiology, 2002, Volume: 75, Issue:893

    Topics: Aged; Antimetabolites; Antioxidants; Breast Neoplasms; Clodronic Acid; Drug Therapy, Combination; Fe

2002
Pentoxifylline and wellbeing in patients with cancer.
    Lancet (London, England), 1990, Mar-17, Volume: 335, Issue:8690

    Topics: Adult; Breast Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lung Neoplas

1990