pentoxifylline has been researched along with Brain Ischemia in 43 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effect of intravenous or oral methylxanthines (pentoxifylline, propentofylline, or pentifylline) in patients with acute ischaemic stroke." | 8.82 | Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. ( Bath, PM; Bath-Hextall, FJ, 2004) |
| "The objective of this review was to assess the effect of intravenous or oral methylxanthines (pentoxifylline, propentofylline, or pentifylline) in patients with acute ischaemic stroke." | 8.80 | Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. ( Asplund, K; Bath, FJ; Bath, PM, 2000) |
| "The influence of vinpocetine, pentoxifylline and enalapril on endothelium functions has been studied in a group of in 172 patients with chronic brain ischemia." | 7.77 | [Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia]. ( Alifirova, VM; Vaizova, OE; Vengerovsky, AI, 2011) |
| "The possible neuroprotector effects of pentoxifylline (P), a methylxanthine derivative and phosphodiesterase inhibitor, were studied on male Wistar rats subjected to a model of transient brain ischemia." | 7.75 | Pentoxifylline treatment improves neurological and neurochemical deficits in rats subjected to transient brain ischemia. ( Batista, TM; Bruno, Rde B; Cunha, GM; de Arruda, KG; Lima, JC; Lima, PF; Marques, TF; Santos, Nda S; Viana, GS; Vitor, HV, 2009) |
| "The effect of pentoxifylline on regional cerebral ischemia was evaluated in 22 cats." | 7.66 | Pentoxifylline in regional cerebral ischemia in cats. ( Michenfelder, JD; Milde, JH; Steen, PA, 1982) |
| "Treatment with pentoxifylline significantly recovered the cerebral ischemia reperfusion‑induced neurological deficit score and cerebral infarct volume in rats." | 5.48 | Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway. ( Dong, J; Xie, W; Yuan, X, 2018) |
| "Cerebral edema is the most common cause of neurological deterioration and mortality during acute ischemic stroke." | 5.37 | Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats. ( Akhavan, MM; Mojarrad, S; Rashidy-Pour, A; Vakili, A, 2011) |
| "Pentoxifylline treatment during reperfusion resulted in no recovery of cerebral blood flow or oxygen consumption." | 5.29 | Effects of pentoxifylline on cerebral blood flow, metabolism, and evoked response after total cerebral ischemia in dogs. ( Kirsch, JR; Maruki, Y; Toung, TJ; Traystman, RJ, 1994) |
| "To assess the effect of intravenous or oral methylxanthines (pentoxifylline, propentofylline, or pentifylline) in patients with acute ischaemic stroke." | 4.82 | Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. ( Bath, PM; Bath-Hextall, FJ, 2004) |
| "The objective of this review was to assess the effect of intravenous or oral methylxanthines (pentoxifylline, propentofylline, or pentifylline) in patients with acute ischaemic stroke." | 4.80 | Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. ( Asplund, K; Bath, FJ; Bath, PM, 2000) |
| "The influence of vinpocetine, pentoxifylline and enalapril on endothelium functions has been studied in a group of in 172 patients with chronic brain ischemia." | 3.77 | [Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia]. ( Alifirova, VM; Vaizova, OE; Vengerovsky, AI, 2011) |
| "The possible neuroprotector effects of pentoxifylline (P), a methylxanthine derivative and phosphodiesterase inhibitor, were studied on male Wistar rats subjected to a model of transient brain ischemia." | 3.75 | Pentoxifylline treatment improves neurological and neurochemical deficits in rats subjected to transient brain ischemia. ( Batista, TM; Bruno, Rde B; Cunha, GM; de Arruda, KG; Lima, JC; Lima, PF; Marques, TF; Santos, Nda S; Viana, GS; Vitor, HV, 2009) |
| "The protective efficacy of pentoxiphylline, piracetam, and dihydroergotoxine against abrupt hypoxia was tested in a model of acute reversible respiratory failure, where repeated apnoeic attacks were induced by inhalation in repeated hypoxic exposures was reduced in control as well as in dihydroergotoxine-treated animals, it was increased after pentoxiphylline, and was not changed after piracetam." | 3.67 | Anti-hypoxic potency of cerebroprotective drugs studied in a model of acute reversible respiratory failure. ( Nistiarová, A; Tkácová, R; Tomori, Z, 1989) |
| "The effect of pentoxifylline on regional cerebral ischemia was evaluated in 22 cats." | 3.66 | Pentoxifylline in regional cerebral ischemia in cats. ( Michenfelder, JD; Milde, JH; Steen, PA, 1982) |
| "As part of a multicenter treatment trial of vascular dementia, this method was then used to analyze MR films in 13 patients with vascular dementia who all had an MR study at baseline and at 1 year." | 2.68 | Volumetric measurement of multifocal brain lesions. Implications for treatment trials of vascular dementia and multiple sclerosis. ( Broderick, JP; Dhawan, AP; Gaskill, M; Khoury, J; Narayan, S, 1996) |
| "Pentoxifylline was administered intravenously in a dose of 600 mg daily for 5 days, together with oral aspirin 150 mg daily." | 2.67 | Pentoxifylline in the treatment of acute ischaemic stroke--a reappraisal in Chinese stroke patients. ( Chan, YW; Kay, CS, 1993) |
| "Bilateral common carotid artery stenosis (BCAS) mouse model was established to mimic VAD." | 1.72 | Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance. ( Cao, R; Chen, Y; Duan, M; Jia, J; Liu, R; Xu, Y; Zhang, M; Zheng, L, 2022) |
| "Treatment with pentoxifylline significantly recovered the cerebral ischemia reperfusion‑induced neurological deficit score and cerebral infarct volume in rats." | 1.48 | Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway. ( Dong, J; Xie, W; Yuan, X, 2018) |
| "Cerebral edema is the most common cause of neurological deterioration and mortality during acute ischemic stroke." | 1.37 | Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats. ( Akhavan, MM; Mojarrad, S; Rashidy-Pour, A; Vakili, A, 2011) |
| "Pentoxifylline pretreatment reduced the incidence of liquefactive cerebral infarction, from 75% in controls to 10% with pentoxifylline, 40 mg/kg/dose (p<0." | 1.31 | Pentoxifylline attenuates hypoxic-ischemic brain injury in immature rats. ( Barks, JD; Eun, BL; Liu, XH, 2000) |
| "Pentoxifylline treatment during reperfusion resulted in no recovery of cerebral blood flow or oxygen consumption." | 1.29 | Effects of pentoxifylline on cerebral blood flow, metabolism, and evoked response after total cerebral ischemia in dogs. ( Kirsch, JR; Maruki, Y; Toung, TJ; Traystman, RJ, 1994) |
| "Thoracotomy was performed, and cardiac arrest (ventricular fibrillation) was induced by direct application of a 2-V DC countershock." | 1.29 | Pentoxifylline ameliorates postischemic delayed hypoperfusion of the cerebral cortex following cardiac arrest in cats. ( Fukuuchi, Y; Kobari, M; Takeda, H; Tanahashi, N; Tomita, M; Yokoyama, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (44.19) | 18.7374 |
| 1990's | 11 (25.58) | 18.2507 |
| 2000's | 6 (13.95) | 29.6817 |
| 2010's | 6 (13.95) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, L | 1 |
| Jia, J | 1 |
| Chen, Y | 1 |
| Liu, R | 1 |
| Cao, R | 1 |
| Duan, M | 1 |
| Zhang, M | 1 |
| Xu, Y | 1 |
| Dong, J | 1 |
| Yuan, X | 1 |
| Xie, W | 1 |
| Atochin, DN | 1 |
| Chernysheva, GA | 1 |
| Smolyakova, VI | 2 |
| Osipenko, AN | 1 |
| Logvinov, SV | 1 |
| Zhdankina, AA | 1 |
| Sysolyatin, SV | 1 |
| Kryukov, YA | 1 |
| Anfinogenova, Y | 1 |
| Plotnikova, TM | 1 |
| Plotnikov, MB | 2 |
| Ivanov, IS | 1 |
| Kuchin, AV | 1 |
| Chukicheva, IJ | 1 |
| Krasnov, EA | 1 |
| Bruno, Rde B | 1 |
| Marques, TF | 1 |
| Batista, TM | 1 |
| Lima, JC | 1 |
| de Arruda, KG | 1 |
| Lima, PF | 1 |
| Santos, Nda S | 1 |
| Cunha, GM | 1 |
| Vitor, HV | 1 |
| Viana, GS | 1 |
| Musaev, AV | 1 |
| Balakishieva, FK | 1 |
| Vakili, A | 1 |
| Mojarrad, S | 1 |
| Akhavan, MM | 1 |
| Rashidy-Pour, A | 1 |
| Vaizova, OE | 1 |
| Vengerovsky, AI | 1 |
| Alifirova, VM | 1 |
| Chukanova, EI | 1 |
| Khodzhamzharov, BÉ | 1 |
| Chukanova, AS | 1 |
| Banfi, C | 1 |
| Sironi, L | 1 |
| De Simoni, G | 1 |
| Gelosa, P | 1 |
| Barcella, S | 1 |
| Perego, C | 1 |
| Gianazza, E | 1 |
| Guerrini, U | 1 |
| Tremoli, E | 1 |
| Mussoni, L | 1 |
| Bath, PM | 2 |
| Bath-Hextall, FJ | 1 |
| Agostoni, A | 1 |
| Nardini, M | 1 |
| Passero, S | 1 |
| Battistini, N | 1 |
| Fieschi, C | 1 |
| Schneider, R | 2 |
| Schmid-Schönbein, H | 2 |
| Kiesewetter, H | 3 |
| Shtok, VN | 1 |
| Fedorova, NV | 1 |
| Gadanova, IV | 1 |
| Steen, PA | 1 |
| Milde, JH | 1 |
| Michenfelder, JD | 1 |
| Dauer, U | 1 |
| Mussler, K | 1 |
| Teitel, P | 1 |
| Seiffge, D | 1 |
| Strano, A | 1 |
| Davì, G | 1 |
| Novo, S | 1 |
| Avellone, G | 1 |
| Pinto, A | 1 |
| Muggeo, M | 1 |
| Calabrò, A | 1 |
| Businaro, V | 1 |
| Patussi, L | 1 |
| Volpe, A | 1 |
| Signorini, GP | 1 |
| Crepaldi, G | 1 |
| Beyreder, J | 1 |
| Melaragno Filho, R | 1 |
| Chan, YW | 1 |
| Kay, CS | 1 |
| Gara, II | 1 |
| Gaur, SP | 1 |
| Garg, RK | 1 |
| Kar, AM | 1 |
| Srimal, RC | 1 |
| Santos, MT | 1 |
| Vallés, J | 2 |
| Aznar, J | 2 |
| Yayá, R | 2 |
| Perez-Requejo, JL | 1 |
| Bleck, TP | 1 |
| Toung, TJ | 1 |
| Kirsch, JR | 1 |
| Maruki, Y | 1 |
| Traystman, RJ | 1 |
| Tanahashi, N | 1 |
| Fukuuchi, Y | 1 |
| Tomita, M | 1 |
| Kobari, M | 1 |
| Takeda, H | 1 |
| Yokoyama, M | 1 |
| Broderick, JP | 1 |
| Narayan, S | 1 |
| Gaskill, M | 1 |
| Dhawan, AP | 1 |
| Khoury, J | 1 |
| Brola, W | 1 |
| Evans, SM | 1 |
| Pinto Pereira, LM | 1 |
| Addae, JI | 1 |
| Eun, BL | 1 |
| Liu, XH | 1 |
| Barks, JD | 1 |
| Bath, FJ | 1 |
| Asplund, K | 1 |
| Müller, R | 2 |
| Schröer, R | 1 |
| Cohen, MM | 1 |
| Harrison, W | 1 |
| Gray, R | 1 |
| Becker, R | 1 |
| Chrobocek, J | 1 |
| Johansson, BB | 1 |
| Olsson, AL | 1 |
| Tkácová, R | 1 |
| Tomori, Z | 1 |
| Nistiarová, A | 1 |
| Lechner, H | 2 |
| Schmidt, R | 1 |
| Ott, E | 1 |
| Körner, E | 1 |
| Vayá, A | 1 |
| Villa, P | 1 |
| Santos, T | 1 |
| Martinez-Sales, V | 1 |
6 reviews available for pentoxifylline and Brain Ischemia
| Article | Year |
|---|---|
[Current possibilities of the correction of oxidative stress in acute brain ischaemia].
Topics: Antioxidants; Brain Ischemia; Humans; Oxidative Stress; Pentoxifylline; Piracetam; Reactive Oxygen S | 2012 |
Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke.
Topics: Brain Ischemia; Humans; Neuroprotective Agents; Pentoxifylline; Platelet Aggregation Inhibitors; Str | 2004 |
[The importance of clinical hemorheology in the study of cerebral blood flow in normal conditions and in cerebrovascular ischemia].
Topics: Ancrod; Animals; Blood Viscosity; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; | 1995 |
Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke.
Topics: Brain Ischemia; Humans; Neuroprotective Agents; Pentoxifylline; Platelet Aggregation Inhibitors; Str | 2000 |
Pentoxifylline -- a biomedical profile.
Topics: Arterial Occlusive Diseases; Blood Viscosity; Brain Ischemia; Cerebrovascular Circulation; Erythrocy | 1979 |
Cerebrovascular circulatory disorders: new aspects of pathophysiology and therapy.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Cell Membrane Permeability; Cer | 1979 |
6 trials available for pentoxifylline and Brain Ischemia
| Article | Year |
|---|---|
[Therapy of acute cerebrovascular insufficiency].
Topics: Acute Disease; Arrhythmias, Cardiac; Brain Ischemia; Cerebral Infarction; Double-Blind Method; Femal | 1981 |
Pentoxifylline in the treatment of acute ischaemic stroke--a reappraisal in Chinese stroke patients.
Topics: Acute Disease; Aged; Asian People; Brain Ischemia; Cerebrovascular Disorders; China; Double-Blind Me | 1993 |
Volumetric measurement of multifocal brain lesions. Implications for treatment trials of vascular dementia and multiple sclerosis.
Topics: Aspirin; Brain; Brain Ischemia; Dementia, Vascular; Double-Blind Method; Female; Humans; Magnetic Re | 1996 |
[Evaluation of treatment outcome after nicergoline and pentoxifylline in patients with ischemic stroke].
Topics: Adult; Aged; Brain Ischemia; Female; Humans; Karnofsky Performance Status; Male; Middle Aged; Nicerg | 1997 |
Hemorheologic treatment of cerebral reversible ischemic episodes with pentoxifylline--a prospective study.
Topics: Aged; Blood Circulation; Brain Ischemia; Erythrocyte Deformability; Female; Humans; Male; Middle Age | 1988 |
Effect of dipyridamole plus pentoxifylline in patients with diffuse cerebrovascular insufficiency.
Topics: Aged; Brain Ischemia; Clinical Trials as Topic; Dipyridamole; Drug Therapy, Combination; Female; Hum | 1985 |
31 other studies available for pentoxifylline and Brain Ischemia
| Article | Year |
|---|---|
Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance.
Topics: Animals; Brain Ischemia; c-Mer Tyrosine Kinase; Carotid Stenosis; Dementia, Vascular; Mice; Microgli | 2022 |
Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion‑induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Caspase 3; Cyclooxygenase 2; Cytokines; Disease M | 2018 |
Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats.
Topics: Animals; Antioxidants; Behavior, Animal; Brain Ischemia; CA1 Region, Hippocampal; Cerebral Infarctio | 2016 |
Antithrombogenic and antiplatelet activity of optho-isobornyl phenol derivative.
Topics: Animals; Brain Ischemia; Camphanes; Cresols; Fibrinolytic Agents; Male; Pentoxifylline; Platelet Agg | 2008 |
Pentoxifylline treatment improves neurological and neurochemical deficits in rats subjected to transient brain ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Avoidance Learning; Brain; Brain Ischemia; Cognition; Dopam | 2009 |
[Electrophoresis of vasoactive drugs in the treatment and rehabilitation of patients with cerebral ischemic diseases].
Topics: Adult; Aged; Antihypertensive Agents; Brain Ischemia; Electrophoresis; Female; Humans; Male; Middle | 2010 |
Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Disease Models, Animal; Free Radical Scavengers; Infarc | 2011 |
[Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia].
Topics: Adult; Aged; Antihypertensive Agents; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulat | 2011 |
Pentoxifylline prevents spontaneous brain ischemia in stroke-prone rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Inflammation; Male; Pentoxifylline; Proteinuria; Ra | 2004 |
[Current status of medical treatment].
Topics: Aminophylline; Animals; Anticoagulants; Aspirin; Barbiturates; Brain Ischemia; Cerebrovascular Disor | 1980 |
Pathophysiology of cerebral blood flow in brain ischemia.
Topics: Brain Ischemia; Carbon Dioxide; Cerebrovascular Circulation; Dextrans; Humans; Pentoxifylline; Radio | 1981 |
The rheological efficiency of parenteral pentoxifylline (Trental) in patients with ischemic brain lesions. Preliminary results.
Topics: Adult; Aged; Blood Viscosity; Brain Ischemia; Erythrocyte Aggregation; Erythrocytes; Female; Hematoc | 1983 |
[Clinical study of the cerebrovascular action of pentoxifylline].
Topics: Acute Disease; Adult; Arteriosclerosis; Brain Ischemia; Cerebrovascular Disorders; Chronic Disease; | 1982 |
Pentoxifylline in regional cerebral ischemia in cats.
Topics: Animals; Brain Ischemia; Cats; Cerebral Infarction; Cerebrovascular Circulation; Female; Male; Pento | 1982 |
[Parenteral pentoxifylline treatment of ischemic cerebrovascular accident. Preliminary results].
Topics: Aged; Blood Viscosity; Brain Ischemia; Erythrocyte Aggregation; Female; Hematocrit; Humans; Infusion | 1982 |
Specific methods to determine hemorheological parameters.
Topics: Arterial Occlusive Diseases; Brain Ischemia; Erythrocyte Aggregation; Erythrocytes; Hematologic Test | 1981 |
[Clinical evaluation of the effects of pentoxifylline in patients with chronic peripheral circulatory disorders].
Topics: Aged; Arteriosclerosis Obliterans; Blood Pressure; Blood Viscosity; Brain Ischemia; Drug Evaluation; | 1981 |
[Hemocoagulation, fibrinolytic and rheologic parameters in ischemic vasculopathy. Effects of pentoxifylline in the treatment of acute cerebral vasculopathy].
Topics: Acute Disease; Blood Coagulation; Brain Ischemia; Drug Evaluation; Female; Fibrinogen; Fibrinolysis; | 1981 |
[The effect of pentoxifylline and nicergoline on the systemic and cerebral hemodynamics and on the blood rheological properties in patients with an ischemic stroke and atherosclerotic lesions of the major cerebral arteries].
Topics: Acute Disease; Adult; Aged; Blood Flow Velocity; Blood Viscosity; Brain Ischemia; Cerebrovascular Di | 1993 |
Effect of anti-platelet therapy (aspirin + pentoxiphylline) on plasma lipids in patients of ischaemic stroke.
Topics: Adult; Aged; Aspirin; Blood Chemical Analysis; Brain Ischemia; Drug Therapy, Combination; Female; Hu | 1993 |
Effects of dipyridamole, pentoxifylline or dipyridamole plus pentoxifylline on platelet reactivity in patients with ischemic cerebrovascular insufficiency.
Topics: Aged; Blood Platelets; Brain Ischemia; Collagen; Dipyridamole; Drug Therapy, Combination; Female; Hu | 1993 |
On the threshold of a dream.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Humans; Pentoxifylline | 1994 |
Effects of pentoxifylline on cerebral blood flow, metabolism, and evoked response after total cerebral ischemia in dogs.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Dogs; Evoked Potentials | 1994 |
Pentoxifylline ameliorates postischemic delayed hypoperfusion of the cerebral cortex following cardiac arrest in cats.
Topics: Animals; Blood Pressure; Brain Ischemia; Cardiopulmonary Resuscitation; Cats; Cerebrovascular Circul | 1995 |
Neuroprotection by caffeine and pentoxifylline during experimental cerebral ischaemia.
Topics: Animals; Brain Ischemia; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Disease Model | 1999 |
Pentoxifylline attenuates hypoxic-ischemic brain injury in immature rats.
Topics: Animals; Brain; Brain Ischemia; Hypoxia; Pentoxifylline; Rats; Rats, Sprague-Dawley | 2000 |
The effect of pentoxifylline on cerebral ischemia and amino acid incorporation into gerbil brain.
Topics: Amino Acids; Animals; Brain; Brain Ischemia; Gerbillinae; Pentoxifylline; Theobromine | 1979 |
[The effectiveness of antiplatelet therapy in ischemic cerebrovascular attacks in the chronic stage].
Topics: Aspirin; Brain Ischemia; Dipyridamole; Female; Hemiplegia; Humans; Male; Middle Aged; Pentoxifylline | 1989 |
Pentoxifylline does not reduce cerebral ischemic edema in hypertensive rats.
Topics: Animals; Brain Edema; Brain Ischemia; Male; Pentoxifylline; Rats; Rats, Inbred SHR; Theobromine | 1989 |
Anti-hypoxic potency of cerebroprotective drugs studied in a model of acute reversible respiratory failure.
Topics: Animals; Brain Ischemia; Cats; Dihydroergotoxine; Disease Models, Animal; Electrocardiography; Hypox | 1989 |
[Pharmacological and therapeutic features of cerebral ischemic conditions].
Topics: Aspirin; Blood Flow Velocity; Blood Viscosity; Brain Ischemia; Cerebrovascular Circulation; Combined | 1988 |