pentoxifylline has been researched along with Brain Edema in 10 studies
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentoxifylline (PTX) is a methylxanthine derivative clinically proven to improve perfusion in the peripheral microcirculation and has been shown to have neuroprotective effects in brain trauma and global cerebral ischemia in experimental animal models." | 5.43 | Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage. ( Aslan, M; Demır, N; Dilmac, S; Dogan, O; Goksu, E; Kirac, E; Konuk, E; Tanrıover, G; Ulker, P, 2016) |
| "Cerebral edema is the most common cause of neurological deterioration and mortality during acute ischemic stroke." | 5.37 | Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats. ( Akhavan, MM; Mojarrad, S; Rashidy-Pour, A; Vakili, A, 2011) |
| "Pentoxifylline is a drug known to increase red cell deformability, thus allowing the 7- to 8-micrometers diameter red cell to flow through the narrowest capillaries of 3-5 micrometers diameter." | 2.36 | Pentoxifylline and cerebrovascular diseases. ( George, C; Marcel, GA, 1983) |
| "Pentoxifylline (PTX) is a methylxanthine derivative clinically proven to improve perfusion in the peripheral microcirculation and has been shown to have neuroprotective effects in brain trauma and global cerebral ischemia in experimental animal models." | 1.43 | Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage. ( Aslan, M; Demır, N; Dilmac, S; Dogan, O; Goksu, E; Kirac, E; Konuk, E; Tanrıover, G; Ulker, P, 2016) |
| "Cerebral edema is the most common cause of neurological deterioration and mortality during acute ischemic stroke." | 1.37 | Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats. ( Akhavan, MM; Mojarrad, S; Rashidy-Pour, A; Vakili, A, 2011) |
| "Thus, ischemic cerebral edema appears to contribute heavily to morbidity and mortality in stroke." | 1.26 | Cerebral edema in stroke: a common, often fatal complication. ( Easton, JD; Sherman, DG, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamidian Jahromi, A | 1 |
| Youssef, AM | 1 |
| Goksu, E | 1 |
| Dogan, O | 1 |
| Ulker, P | 1 |
| Tanrıover, G | 1 |
| Konuk, E | 1 |
| Dilmac, S | 1 |
| Kirac, E | 1 |
| Demır, N | 1 |
| Aslan, M | 1 |
| Williamson, R | 1 |
| Kondziolka, D | 1 |
| Kanaan, H | 1 |
| Lunsford, LD | 1 |
| Flickinger, JC | 1 |
| Vakili, A | 1 |
| Mojarrad, S | 1 |
| Akhavan, MM | 1 |
| Rashidy-Pour, A | 1 |
| Marcel, GA | 1 |
| George, C | 1 |
| Sherman, DG | 1 |
| Easton, JD | 1 |
| Shohami, E | 1 |
| Bass, R | 1 |
| Wallach, D | 1 |
| Yamin, A | 1 |
| Gallily, R | 1 |
| Rosenberg, GA | 1 |
| Navratil, M | 1 |
| Müller, R | 1 |
| Schröer, R | 1 |
| Johansson, BB | 1 |
| Olsson, AL | 1 |
2 reviews available for pentoxifylline and Brain Edema
| Article | Year |
|---|---|
Pentoxifylline and cerebrovascular diseases.
Topics: Animals; Blood Viscosity; Brain Edema; Cerebrovascular Circulation; Cerebrovascular Disorders; Dogs; | 1983 |
Cerebrovascular circulatory disorders: new aspects of pathophysiology and therapy.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Cell Membrane Permeability; Cer | 1979 |
8 other studies available for pentoxifylline and Brain Edema
| Article | Year |
|---|---|
Potential cerebroprotective role of pentoxifyllin in preventing the detrimental cerebral consequences of intra-abdominal hypertension.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebrovascular Circulation; Craniocerebral Trauma; Disea | 2014 |
Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Inflammation; Mal | 2016 |
Adverse radiation effects after radiosurgery may benefit from oral vitamin E and pentoxifylline therapy: a pilot study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Brain Edema; Child; Drug Therapy, Combination; Female | 2008 |
Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Disease Models, Animal; Free Radical Scavengers; Infarc | 2011 |
Cerebral edema in stroke: a common, often fatal complication.
Topics: Adrenal Cortex Hormones; Antioxidants; Barbiturates; Brain Edema; Cerebral Infarction; Cerebrovascul | 1980 |
Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Carrier Proteins; Cell Survival; Head Injuries, Cl | 1996 |
Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat.
Topics: Animals; Benzyl Compounds; Brain; Brain Edema; Cerebral Hemorrhage; Collagenases; Dexamethasone; Dru | 1997 |
Pentoxifylline does not reduce cerebral ischemic edema in hypertensive rats.
Topics: Animals; Brain Edema; Brain Ischemia; Male; Pentoxifylline; Rats; Rats, Inbred SHR; Theobromine | 1989 |