Page last updated: 2024-11-02

pentoxifylline and Anemia, Sickle Cell

pentoxifylline has been researched along with Anemia, Sickle Cell in 26 studies

Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.

Research Excerpts

ExcerptRelevanceReference
"A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months."7.68Treatment of sickle cell leg ulcers with pentoxifylline. ( Frost, ML; Treadwell, P, 1990)
"A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months."3.68Treatment of sickle cell leg ulcers with pentoxifylline. ( Frost, ML; Treadwell, P, 1990)
"The lower legs of homozygous sickle cell anemia patients are areas of marginal vascularity where minor abrasions become foci of inflammation."2.40[Falciform anemia and Plasmodium falciparum malaria: a threat to flap survival?]. ( Humbert, J; Loutan, L; Mariéthoz, S; Montandon, D; Pittet, B, 1999)
" Further increase in pentoxifylline dosage to 400 mg four times daily did not result in any further improvement in these hematologic parameters."1.30Treatment of homozygous sickle cell disease with pentoxifylline. ( Sacerdote, A, 1999)
"Women complained of insomnia in the middle of the night and somatic anxiety and presented higher total scores than men."1.29[Sickle cell disease and depression: preliminary study using the Hamilton rating scale for depression]. ( Buguet, A; Sangare, A; Segbena, A, 1994)
"Pentoxifylline does not enhance RBC deformability following acute in vitro incubation, and this suggests the need for further evaluation of the mechanism of action of this drug."1.28Effects of pentoxifylline and metabolite on red blood cell deformability as measured by ektacytometry. ( Ballas, SK; Cummings, DM, 1990)
"Pentoxifylline was shown to prevent sickling induced by deoxygenation of SS-genotype blood from sickle cell disease patients."1.27Studies on the vasoocclusive crisis of sickle cell disease IV. Mechanism of action of pentoxifylline (Trental). ( Ambrus, JL; Gastpar, H; Meky, N; Raposa, T; Sills, RH; Stadler, S, 1988)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199014 (53.85)18.7374
1990's9 (34.62)18.2507
2000's2 (7.69)29.6817
2010's1 (3.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Altman, IA1
Kleinfelder, RE1
Quigley, JG1
Ennis, WJ1
Minniti, CP1
Sacerdote, A1
Trent, JT1
Kirsner, RS1
Ambrus, JL5
Ambrus, CM3
Bannerman, R2
Sills, RH2
Meky, NN1
Khosla, AA1
Chintu, C1
Seiffge, D1
Berthold, R1
Berthold, F1
Keller, F2
Leonhardt, H2
Segbena, A1
Buguet, A1
Sangare, A1
Fall, AB1
Toppet, M1
Ferster, A1
Fondu, P1
Vanhaelen-Fastré, R1
Vanhaelen, M1
Mariéthoz, S1
Pittet, B1
Loutan, L1
Humbert, J1
Montandon, D1
de Seixas, MA1
Franchin Júnior, CA1
Silva, CE1
Leal, SM1
Ortiz, J1
Sherer, JT1
Glover, PH1
Gastpar, H3
Bettigole, R1
Friedman, S1
Toumbis, CA1
Stadler, I1
Poflee, VW1
Gupta, OP1
Jain, AP1
Jajoo, UN1
Cummings, DM1
Ballas, SK1
Frost, ML1
Treadwell, P1
Teuscher, T1
Von Der Ahe, CW1
Baillod, P1
Holzer, B1
Billett, HH1
Kaul, DK1
Connel, MM1
Fabry, ME1
Nagel, RL1
Clerc, M1
Doh-Egueli, D1
Chapuis, F1
Durin, A1
Bertrand, Y1
Souillet, G1
Philippe, N1
Stuart, J1
Stone, PC1
Bilto, YY1
Keidan, AJ1
Meky, N1
Stadler, S1
Raposa, T1
Manrique, RV1
Pichard, E1
Duflo, B1
Coulibaly, S1
Mariko, B1
Monsempes, JL1
Traore, HA1
Diallo, AD1

Reviews

4 reviews available for pentoxifylline and Anemia, Sickle Cell

ArticleYear
A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease.
    International wound journal, 2016, Volume: 13, Issue:6

    Topics: Administration, Oral; Administration, Topical; Algorithms; Anemia, Sickle Cell; Bandages; Combined M

2016
Leg ulcers in sickle cell disease.
    Advances in skin & wound care, 2004, Volume: 17, Issue:8

    Topics: Anemia, Sickle Cell; Antisickling Agents; Bandages; Blood Transfusion; Carnitine; Debridement; Drug

2004
[Falciform anemia and Plasmodium falciparum malaria: a threat to flap survival?].
    Annales de chirurgie plastique et esthetique, 1999, Volume: 44, Issue:1

    Topics: Anemia, Sickle Cell; Antisickling Agents; Child; Humans; Hydroxyurea; Leg Ulcer; Malaria, Falciparum

1999
Pentoxifylline for sickle-cell disease.
    The Annals of pharmacotherapy, 2000, Volume: 34, Issue:9

    Topics: Anemia, Sickle Cell; Animals; Clinical Trials as Topic; Disease Models, Animal; Female; Haplorhini;

2000

Trials

6 trials available for pentoxifylline and Anemia, Sickle Cell

ArticleYear
A pilot study: an open clinical trial of pentoxiphylline in patients with painful sickle cell crises.
    East African medical journal, 1984, Volume: 61, Issue:11

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Clinical Trials as Topic; Female; H

1984
Haemorheological treatment of painful sickle cell crises. Use of pentoxifylline.
    The Journal of the Association of Physicians of India, 1991, Volume: 39, Issue:8

    Topics: Adult; Anemia, Sickle Cell; Humans; Pain; Pentoxifylline; Peripheral Vascular Diseases

1991
Double-blind randomised clinical trial of pentoxiphyllin in vaso-occlusive sickle cell crisis.
    Tropical and geographical medicine, 1989, Volume: 41, Issue:4

    Topics: Acute Disease; Adolescent; Analgesics; Anemia, Sickle Cell; Child; Double-Blind Method; Female; Huma

1989
Pentoxifylline (Trental) has no significant effect on laboratory parameters in sickle cell disease.
    Nouvelle revue francaise d'hematologie, 1989, Volume: 31, Issue:6

    Topics: Administration, Oral; Adult; Anemia, Sickle Cell; Bicarbonates; Blood Cell Count; Blood Viscosity; D

1989
Placebo controlled double-blind study of pentoxifylline in sickle cell disease patients.
    Journal of medicine, 1987, Volume: 18, Issue:5-6

    Topics: Adolescent; Anemia, Sickle Cell; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Count; F

1987
[Effectiveness of treatment during osteoarticular pain crises in drepanocytosis; based on the example of pentoxifylline].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:5

    Topics: Adult; Anemia, Sickle Cell; Double-Blind Method; Drug Evaluation; Erythrocyte Deformability; Female;

1987

Other Studies

16 other studies available for pentoxifylline and Anemia, Sickle Cell

ArticleYear
Treatment of homozygous sickle cell disease with pentoxifylline.
    Journal of the National Medical Association, 1999, Volume: 91, Issue:8

    Topics: Adult; Anemia, Sickle Cell; Female; Hematologic Agents; Homozygote; Humans; Pentoxifylline

1999
Studies on the management and prevention of vasoocclusive crisis in sickle cell disease.
    Journal of medicine, 1984, Volume: 15, Issue:5-6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Anemia, Sickle Cell; Animals; Cell Aggregation; Erythrocyte Def

1984
Effect of pentoxifylline on sickle cell thalassaemia: haemorheological and clinical results.
    Klinische Wochenschrift, 1983, Nov-15, Volume: 61, Issue:22

    Topics: Adolescent; Anemia, Sickle Cell; Blood Viscosity; Erythrocytes; Female; Humans; Pentoxifylline; Theo

1983
[Improvement of blood viscosity in sickle-cell anaemia by pentoxifylline (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1980, Jun-20, Volume: 105, Issue:25

    Topics: Adolescent; Anemia, Sickle Cell; Blood Viscosity; Female; Hemolysis; Humans; Male; Microcirculation;

1980
[Sickle cell disease and depression: preliminary study using the Hamilton rating scale for depression].
    Medecine tropicale : revue du Corps de sante colonial, 1994, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Anemia, Sickle Cell; Anxiety Disorders; Case-Control Studie

1994
In vitro antisickling activity of cromolyn sodium.
    British journal of haematology, 1998, Volume: 103, Issue:4

    Topics: Anemia, Sickle Cell; Antisickling Agents; Cromolyn Sodium; Hematologic Agents; Humans; In Vitro Tech

1998
Myocardial bridge in a patient with sickle cell anemia.
    Arquivos brasileiros de cardiologia, 1999, Volume: 72, Issue:2

    Topics: Adult; Anemia, Sickle Cell; Ascorbic Acid; Coronary Vessel Anomalies; Female; Folic Acid; Free Radic

1999
Studies on platelet aggregation with pentoxifylline: effect on neoplastic disorders and other new indications.
    Journal of medicine, 1979, Volume: 10, Issue:5

    Topics: Anemia, Sickle Cell; Animals; Arteriosclerosis; Blood Viscosity; Embolism; Haplorhini; Humans; Neopl

1979
Amelioration of blood viscosity in sickle cell anemia by pentoxifylline. A case report.
    Journal of medicine, 1979, Volume: 10, Issue:6

    Topics: Adolescent; Anemia, Sickle Cell; Blood Viscosity; Female; Hemolysis; Humans; Pentoxifylline; Theobro

1979
Studies on vasoocclusive crisis of sickle cell disease. I. Effect of pentoxifylline.
    Journal of medicine, 1979, Volume: 10, Issue:6

    Topics: Anemia, Sickle Cell; Animals; Macaca; Magnesium Sulfate; Male; Pentoxifylline; Platelet Aggregation;

1979
Effect of red blood cells from patients with sickle cell disease on platelet factor 3 release.
    American journal of hematology, 1992, Volume: 40, Issue:2

    Topics: Adult; Anemia, Sickle Cell; Erythrocytes; Genotype; Humans; Male; Pentoxifylline; Platelet Activatio

1992
Effects of pentoxifylline and metabolite on red blood cell deformability as measured by ektacytometry.
    Angiology, 1990, Volume: 41, Issue:2

    Topics: Anemia, Sickle Cell; Erythrocyte Deformability; Humans; Pentoxifylline; Theobromine

1990
Treatment of sickle cell leg ulcers with pentoxifylline.
    International journal of dermatology, 1990, Volume: 29, Issue:5

    Topics: Anemia, Sickle Cell; Chronic Disease; Humans; Leg Ulcer; Male; Middle Aged; Pentoxifylline; Recurren

1990
[Treatment of vaso-occlusive crisis of sickle-cell disease with pentoxifylline].
    Pediatrie, 1989, Volume: 44, Issue:7

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Drug Therapy, Combination; Female;

1989
Oxpentifylline and cetiedil citrate improve deformability of dehydrated sickle cells.
    Journal of clinical pathology, 1987, Volume: 40, Issue:10

    Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Calcimycin; Dose-Response Relationship, Drug; Er

1987
Studies on the vasoocclusive crisis of sickle cell disease IV. Mechanism of action of pentoxifylline (Trental).
    Journal of medicine, 1988, Volume: 19, Issue:2

    Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Erythrocyte Deformability; Erythrocyte Indices; Humans;

1988