pentostatin and Stomach-Neoplasms

Hairy cell leukemia patients are at increased risk for second malignancies, including both solid and lymphoid neoplasms. Along with other factors, multiple immune defects present in hairy cell leukemia likely contribute to subsequent carcinogenesis. We report herein a case of synchronous high-grade gastric and ampullary adenocarcinomas in a patient with a history of hairy cell leukemia treated eight years prior with pentostatin. We include a review of immune alterations induced by both hairy cell leukemia and its therapies, and link them with the occurrence of second cancers in these patients.

Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Common Bile Duct Neoplasms; Humans; Leukemia, Hairy Cell; Male; Neoplasms, Second Primary; Pancreatic Neoplasms; Pentostatin; Stomach Neoplasms; Time Factors; Treatment Outcome