pentostatin and Leishmaniasis--Cutaneous

The present gold standard of the treatment of cutaneous leishmaniasis (CL) is pentavalent antimonials either sodium stibogluconate (Pentostam) or meglumine antimoniate (Glucantime), These drugs are quite toxic. They are given by injection and usually administered intramuscularly or intravenously for three weeks or intralesionally for seven or more weeks. That is why the successful introduction of radiofrequency-induced heat therapy using a Thermomed™ 1.8 instrument administered in a single application, with minimal toxic effects, is so important for the treatment of CL.

Topics: Adolescent; Adult; Aged; Animals; Antiprotozoal Agents; Child; Child, Preschool; Cytokines; Female; Hot Temperature; Humans; Injections, Intramuscular; Leishmaniasis, Cutaneous; Male; Meglumine Antimoniate; Middle Aged; Pentostatin; Radiofrequency Therapy; Young Adult