pentostatin and Hyperemia

pentostatin has been researched along with Hyperemia* in 1 studies

Other Studies

1 other study(ies) available for pentostatin and Hyperemia

Article	Year
Adenosine deaminase inhibitors enhance cerebral anoxic hyperemia in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1985, Volume: 5, Issue:2 Cerebral blood flow in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of flow over periods of several hours. The adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) (1.0-100 micrograms/kg) and deoxycoformycin (0.1-1 micrograms/kg) potentiated the reactive hyperemia elicited by a brief (24-s) anoxic challenge. Basal flow rate was unaltered by EHNA administration and slightly enhanced by deoxycoformycin. The results are consistent with the hypothesis that adenosine plays a significant role in cerebral vascular regulation and suggest that low doses of these deaminase inhibitors may be useful in the treatment of cerebral vascular insufficiency. Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Brain; Cerebrovascular Circulation; Coformycin; Hyperemia; Hypoxia, Brain; Male; Pentostatin; Rats; Rats, Inbred Strains; Ribonucleosides	1985

Article

Year

Adenosine deaminase inhibitors enhance cerebral anoxic hyperemia in the rat.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1985, Volume: 5, Issue:2

Cerebral blood flow in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of flow over periods of several hours. The adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) (1.0-100 micrograms/kg) and deoxycoformycin (0.1-1 micrograms/kg) potentiated the reactive hyperemia elicited by a brief (24-s) anoxic challenge. Basal flow rate was unaltered by EHNA administration and slightly enhanced by deoxycoformycin. The results are consistent with the hypothesis that adenosine plays a significant role in cerebral vascular regulation and suggest that low doses of these deaminase inhibitors may be useful in the treatment of cerebral vascular insufficiency.

Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Brain; Cerebrovascular Circulation; Coformycin; Hyperemia; Hypoxia, Brain; Male; Pentostatin; Rats; Rats, Inbred Strains; Ribonucleosides

1985