pentostatin and Arthritis--Rheumatoid

pentostatin has been researched along with Arthritis--Rheumatoid* in 2 studies

Other Studies

2 other study(ies) available for pentostatin and Arthritis--Rheumatoid

Article	Year
Cd8(+)/V beta 5.1(+) large granular lymphocyte leukemia associated with autoimmune cytopenias, rheumatoid arthritis and vascular mammary skin lesions: successful response to 2-deoxycoformycin. Hematological oncology, 2002, Volume: 20, Issue:2 We report a case of CD8(+)/V beta 5.1(+) T-cell large granular lymphocyte leukemia (T-LGL leukemia) presenting with mild lymphocytosis, severe autoimmune neutropenia, thrombocytopenia, polyarthritis and recurrent infections with a chronic disease course. Immunophenotyping showed an expansion of CD3(+)/TCR alpha beta(+)/CD8(+bright)/CD11c(+)/CD57(-)/CD56(-) large granular lymphocytes with expression of the TCR-V beta 5.1 family. Southern blot analysis revealed a clonal rearrangement of the TCR beta-chain gene. Hematopoietic growth factors, high dose intravenous immunoglobulin and corticosteroids were of limited therapeutic benefit to correct the cytopenias. During the disease course, the patient developed a severe cutaneous leg ulcer and bilateral vascular mammary skin lesions. Treatment with 2-deoxycoformycin resulted in both clinical and hematological complete responses, including the resolution of vascular skin lesions. Combined immuno-staining with relevant T-cell associated and anti-TCR-V beta monoclonal antibodies proved to be a sensitive method to assess the therapeutic effect of 2-deoxycoformicin and to evaluate the residual disease. Topics: Aged; Antibiotics, Antineoplastic; Arthritis, Rheumatoid; Breast; CD3 Complex; CD8 Antigens; Female; Gene Rearrangement, T-Lymphocyte; Humans; Immunophenotyping; Leg Ulcer; Leukemia, Lymphoid; Neutropenia; Pentostatin; Receptors, Antigen, T-Cell, alpha-beta; Thrombocytopenia	2002
Effects of pentostatin (2'deoxycoformycin), an inhibitor of adenosine deaminase, on type II collagen-induced arthritis in rats. Journal of immunopharmacology, 1985, Volume: 7, Issue:3 Pentostatin (2'-deoxycoformycin), a potent inhibitor of adenosine deaminase, was administered therapeutically to rats with type II collagen-induced arthritis and the effects on hindpaw swelling, serum haptoglobin concentration, and anticollagen antibody titer determined. Daily intraperitoneal administration of pentostatin at 10.0 or 1.0 mg/kg/day for three weeks produced significant enhancement of hind-paw swelling and elevation of serum haptoglobin. Continuous subcutaneous infusion of pentostatin at 1.0 or 0.1 mg/kg/day had the same effects. None of the dosing regimens had any effect on anticollagen antibody titer. Topics: Adenosine Deaminase Inhibitors; Animals; Antibodies; Arthritis, Rheumatoid; Coformycin; Collagen; Haptoglobins; Immunosuppressive Agents; Male; Nucleoside Deaminases; Pentostatin; Rats; Ribonucleosides	1985

Article

Year

Cd8(+)/V beta 5.1(+) large granular lymphocyte leukemia associated with autoimmune cytopenias, rheumatoid arthritis and vascular mammary skin lesions: successful response to 2-deoxycoformycin.

Hematological oncology, 2002, Volume: 20, Issue:2

We report a case of CD8(+)/V beta 5.1(+) T-cell large granular lymphocyte leukemia (T-LGL leukemia) presenting with mild lymphocytosis, severe autoimmune neutropenia, thrombocytopenia, polyarthritis and recurrent infections with a chronic disease course. Immunophenotyping showed an expansion of CD3(+)/TCR alpha beta(+)/CD8(+bright)/CD11c(+)/CD57(-)/CD56(-) large granular lymphocytes with expression of the TCR-V beta 5.1 family. Southern blot analysis revealed a clonal rearrangement of the TCR beta-chain gene. Hematopoietic growth factors, high dose intravenous immunoglobulin and corticosteroids were of limited therapeutic benefit to correct the cytopenias. During the disease course, the patient developed a severe cutaneous leg ulcer and bilateral vascular mammary skin lesions. Treatment with 2-deoxycoformycin resulted in both clinical and hematological complete responses, including the resolution of vascular skin lesions. Combined immuno-staining with relevant T-cell associated and anti-TCR-V beta monoclonal antibodies proved to be a sensitive method to assess the therapeutic effect of 2-deoxycoformicin and to evaluate the residual disease.

Topics: Aged; Antibiotics, Antineoplastic; Arthritis, Rheumatoid; Breast; CD3 Complex; CD8 Antigens; Female; Gene Rearrangement, T-Lymphocyte; Humans; Immunophenotyping; Leg Ulcer; Leukemia, Lymphoid; Neutropenia; Pentostatin; Receptors, Antigen, T-Cell, alpha-beta; Thrombocytopenia

2002

Effects of pentostatin (2'deoxycoformycin), an inhibitor of adenosine deaminase, on type II collagen-induced arthritis in rats.

Journal of immunopharmacology, 1985, Volume: 7, Issue:3

Pentostatin (2'-deoxycoformycin), a potent inhibitor of adenosine deaminase, was administered therapeutically to rats with type II collagen-induced arthritis and the effects on hindpaw swelling, serum haptoglobin concentration, and anticollagen antibody titer determined. Daily intraperitoneal administration of pentostatin at 10.0 or 1.0 mg/kg/day for three weeks produced significant enhancement of hind-paw swelling and elevation of serum haptoglobin. Continuous subcutaneous infusion of pentostatin at 1.0 or 0.1 mg/kg/day had the same effects. None of the dosing regimens had any effect on anticollagen antibody titer.

Topics: Adenosine Deaminase Inhibitors; Animals; Antibodies; Arthritis, Rheumatoid; Coformycin; Collagen; Haptoglobins; Immunosuppressive Agents; Male; Nucleoside Deaminases; Pentostatin; Rats; Ribonucleosides

1985