pentobarbital has been researched along with Substance Withdrawal Syndrome in 131 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The acute onset of chorea was seen in a ten week-old male following abrupt cessation of a seven-day course of sedation with diazepam and pentobarbital." | 7.68 | Infantile chorea following abrupt withdrawal of diazepam and pentobarbital therapy. ( Ment, LR; Patrick, SJ; Snelling, LK, 1993) |
| " Acute nitrendipine significantly increased the latency of seizures in response to the partial benzodiazepine inverse agonist FG7142 during barbiturate withdrawal, but there was no effect on the seizure incidence in response to bicuculline." | 3.69 | Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal. ( Brown, J; Butterworth, AR; Little, HJ; Rabbani, M, 1994) |
| "The acute onset of chorea was seen in a ten week-old male following abrupt cessation of a seven-day course of sedation with diazepam and pentobarbital." | 3.68 | Infantile chorea following abrupt withdrawal of diazepam and pentobarbital therapy. ( Ment, LR; Patrick, SJ; Snelling, LK, 1993) |
| " Under pentobarbital anesthesia, precipitated shakes and ice water-induced wet shakes were inhibited by clonidine and norepinephrine." | 3.65 | Effects of clonidine on morphine withdrawal signs in the rat. ( Loh, HH; Tseng, LF; Wei, ET, 1975) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| "Chemical lesions did not affect convulsions in response to pentylenetetrazole, which blocks GABA(A) receptor-mediated transmission." | 1.37 | Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice. ( Buck, KJ; Chen, G; Kozell, LB, 2011) |
| "Pentobarbital (42mg/kg) was administered intraperitoneally (i." | 1.35 | Cocaine withdrawal enhances pentobarbital-induced sleep in rats: evidence of GABAergic modulation. ( Hong, JT; Kim, YB; Ma, H; Ma, Y; Nam, SY; Oh, KW, 2008) |
| "Gaboxadol (1." | 1.32 | Progesterone withdrawal increases the anxiolytic actions of gaboxadol: role of alpha4betadelta GABA(A) receptors. ( Gong, QH; Gulinello, M; Smith, SS, 2003) |
| "Pentobarbital was continuously infused intracerebroventricularly (i." | 1.31 | Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats. ( Kim, Y; Oh, S, 2002) |
| "Flunitrazepam was evaluated in several procedures that have been used extensively to study the behavioral effects and abuse potential of positive GABA(A) modulators." | 1.31 | Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats. ( France, CP; Gerak, LR; Harris, LS; Nader, MA; Patrick, GA; Winger, G; Woods, JH; Woolverton, WL, 2001) |
| "Pentobarbital was then administered, resulting in excellent control of behavioral, autonomic, and psychiatric symptoms and in rapid reduction or avoidance of benzodiazepines." | 1.31 | Pentobarbital for severe gamma-butyrolactone withdrawal. ( Aaron, CK; Burns, MJ; Greenberg, MJ; Sivilotti, ML, 2001) |
| "These studies were designed to examine the effect of chronic administration of pentobarbital on activity of adenylate cyclase (AC) and protein kinase C (PKC) in the rat brain by autoradiography." | 1.30 | Changes in [3H]forskolin binding to adenylate cyclase and [3H]phorbol dibutyrate binding to protein kinase C in pentobarbital tolerant/dependent rats. ( Ho, IK; Oh, S; Wellman, SE, 1998) |
| "Here we report on the assessment of withdrawal symptoms in morphine-dependent rats which received continuous naloxone administration combined with barbiturate anaesthesia." | 1.30 | Forced opiate withdrawal under anaesthesia augments and prolongs the occurrence of withdrawal signs in rats. ( Holsboer, F; Kirschke, C; Spanagel, R; Tretter, F, 1998) |
| "Potentially life-threatening seizures can occur following withdrawal from benzodiazepines, ethanol, or barbiturates." | 1.30 | Genetic determinants of severity of acute withdrawal from diazepam in mice: commonality with ethanol and pentobarbital. ( Crabbe, JC; Metten, P, 1999) |
| "To record the number of children with withdrawal symptoms after the administration of sedatives for mechanical ventilation, and to discuss the possible connection with the administration of midazolam." | 1.30 | Occurrence of withdrawal in critically ill sedated children. ( Carl, P; Fonsmark, L; Rasmussen, YH, 1999) |
| "These results suggest that withdrawal convulsions following acute ethanol, pentobarbital, and diazepam are sensitive to modulation by corticosterone and they support the hypothesis that stress may increase drug withdrawal severity." | 1.29 | Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice. ( Crabbe, JC; Keith, LD; Roberts, AJ, 1994) |
| "Aminorex is a cyclic phenylisopropylamine that has been marketed as an anorectic." | 1.29 | Evaluation of the abuse liability of aminorex. ( Harris, LS; Massey, BW; Patrick, GA; Winger, G; Woolverton, WL, 1994) |
| " In the physical dependence test, nefiracetam and codeine phosphate were administered to rats mixed with food for 43 days in a gradually increasing dosage schedule, followed by feeding a drug-free normal diet to detect signs of withdrawal." | 1.29 | Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. ( Akiyama, Y; Fujikawa, K; Takayama, S, 1994) |
| " In Study 2, the chronic administration of diltiazem to PB-infused rats produced both a significant decrease in water consumption at 48 and 72 hours and a significant increase in withdrawal scores from 3-48 hours." | 1.28 | Diltiazem alters some withdrawal signs in pentobarbital-dependent rats. ( Reynen, M; Yutrzenka, GJ, 1991) |
| "Withdrawal seizure prone (WSP) and withdrawal seizure resistant (WRS) mice were genetically selected to express severe or mild handling-induced convulsions (HIC), respectively, after cessation of chronic ethanol (EtOH) vapor inhalation." | 1.28 | Acute dependence on depressant drugs is determined by common genes in mice. ( Belknap, JK; Crabbe, JC; Merrill, C, 1991) |
| "The effect of three dosage schedules on the expression of a withdrawal syndrome indicative of physical dependence on pentobarbital was determined in male Sprague-Dawley rats." | 1.28 | Intensity of the withdrawal syndrome varies with duration of pentobarbital administration. ( Yutrzenka, GJ, 1989) |
| " Animals were treated with Na pentobarbital according to the "maximally tolerable" dosing schedule described previously, twice a day for 35 days, and abruptly withdrawn." | 1.27 | Effects of individual variations in drug elimination kinetics for production of pentobarbital physical dependence. ( Hinman, DJ; Okamoto, M, 1983) |
| "Seizures and delirium tremens were recorded among 292 randomly selected patients admitted to an in-patient alcoholism program." | 1.27 | Should alcohol withdrawal seizures be treated with anti-epileptic drugs? ( Hillbom, ME; Hjelm-Jäger, M, 1984) |
| "CGS-8216, a benzodiazepine antagonist, was administered to rats acutely dosed with diazepam, and to rats chronically dosed with diazepam or pentobarbital." | 1.27 | Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats. ( Martin, WR; McNicholas, LF, 1986) |
| "Fischer 344 (F344), Lewis (LEW), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were chronically fed food containing pentobarbital on an escalating drug dosage schedule over a period of 47 days." | 1.27 | Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats. ( George, FR; Koike, Y; Meisch, RA; Suzuki, T; Yanaura, S, 1987) |
| " Groups of animals were treated with Na pentobarbital according to the "maximally tolerable" dosing schedule described previously, except that with different dose-frequency schedules, i." | 1.27 | Effect of dosing frequency on the development of physical dependence and tolerance to pentobarbital. ( Okamoto, M; Rao, S; Walewski, JL, 1986) |
| " In naive animals, after the chronic administration of midazolam at 0." | 1.27 | [Drug dependence tests on a new anesthesia inducer, midazolam]. ( Hakkei, M; Kubota, A; Kuwahara, A; Nakamura, K, 1986) |
| " Picrotoxin, and agent which blocks the chloride ionophore of GABA-receptor complex, exhibited a parallel dose-response curve with respect to muscimol." | 1.26 | Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: a study with muscimol. ( Ho, IK; Nabeshima, T; Sivam, SP, 1982) |
| " The animals were made physically dependent by 5 weeks of twice daily "maximally tolerable" sodium pentobarbital dosing intragastrically." | 1.26 | Evaluation of anticonvulsants in barbiturate withdrawal. ( Boisse, NR; Okamoto, M; Rosenberg, HC, 1977) |
| "Audiogenic seizure susceptibility and intensity peaked at 6 hours following the last dose, suggesting that a low concentration of barbiturate is more important in increasing seizure propensity than a sudden decrease in concentration." | 1.26 | Time course of audiogenic seizure susceptibility and plasma pentobarbital concentration during withdrawal. ( Bourn, WM; Buice, RG, 1978) |
| "After "chronically equivalent" barbital and pentobarbital dosing for 5 weeks, treatments were abruptly stopped and the animals were carefully observed for signs of barbiturate withdrawal." | 1.26 | Physical dependence to barbital compared to pentobarbital. III. Withdrawal characteristics. ( Boisse, NR; Okamoto, M, 1978) |
| " The rate of barbiturate elimination after chronically equivalent pentobarbital dosing was reduced by barbital substitution or by first-order pentobarbital dose reduction, with the result that withdrawal signs became mild and appeared later (3 days postdrug)." | 1.26 | Physical dependence to barbital compared to pentobarbital. IV. Influence of elimination kinetics. ( Boisse, NR; Okamoto, M, 1978) |
| "The occurrence of convulsions, during periods of complete reduction of the maintenance drug, became less frequent the longer the dogs had been maintained on a constant dose of sodium pentobarbital." | 1.26 | A method for bioassay of physical dependence on sedative drugs in dog. ( Jones, BE; Martin, WR; Prada, JA, 1976) |
| "Cats were made physically dependent on sodium pentobarbital using the "maximally tolerable" dosing technique." | 1.26 | Electrophysiology of barbiturate withdrawal in the spinal cord. ( Okamoto, M; Rosenberg, HC, 1976) |
| " Physical dependence was produced in 63 cats by 'maximally tolerable' dosing with sodium pentobarbital." | 1.26 | Withdrawal characteristics following chronic pentobarbital dosing. ( Boisse, NR; Okamoto, M; Rosenberg, HC, 1976) |
| "6 Animals withdrawn following chronic administration of a number of drugs, barbitone, barbitone/bemegride mixture, Mandrax (methaqualone: diphenhydramine; 10: 1), chlordiazepoxide, nitrazepam, chlorpromazine or ethanol, exhibited a significant tolerance to intracerebroventricularly administered pentobarbitone." | 1.25 | A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs. ( Stevenson, IH; Turnbull, MJ, 1974) |
| " The sensitivity of the central nervous system to barbiturate was determined in rats during the chronic administration of barbitone sodium and after its withdrawal." | 1.25 | The sensitivity of the brain to barbiturate during chronic administration and withdrawal of barbitone sodium in the rat. ( Stevenson, IH; Turnbull, MJ, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 87 (66.41) | 18.7374 |
| 1990's | 27 (20.61) | 18.2507 |
| 2000's | 12 (9.16) | 29.6817 |
| 2010's | 5 (3.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blednov, YA | 1 |
| Benavidez, JM | 1 |
| Black, M | 1 |
| Mayfield, J | 1 |
| Harris, RA | 2 |
| Ma, Y | 1 |
| Ma, H | 1 |
| Hong, JT | 1 |
| Kim, YB | 1 |
| Nam, SY | 1 |
| Oh, KW | 1 |
| Kozell, LB | 2 |
| Walter, NA | 1 |
| Milner, LC | 1 |
| Wickman, K | 1 |
| Buck, KJ | 8 |
| Chen, G | 1 |
| Kontogiorgi, M | 1 |
| Opsimoulis, P | 1 |
| Diamanti-Kandarakis, E | 1 |
| Karabinis, A | 1 |
| Shabanov, PD | 1 |
| Lebedev, AA | 1 |
| Weber, GM | 1 |
| Smerling, AJ | 1 |
| Saroyan, JM | 1 |
| Kim, Y | 1 |
| Oh, S | 5 |
| Gulinello, M | 1 |
| Gong, QH | 1 |
| Smith, SS | 1 |
| DILLE, JR | 1 |
| TANG, PC | 1 |
| FLYNN, SF | 1 |
| HOFFMANN, JC | 1 |
| SCHWARTZ, NB | 1 |
| HAMBURGER, E | 1 |
| RICE, J | 1 |
| COHEN, L | 1 |
| Fehr, C | 2 |
| Shirley, RL | 2 |
| Metten, P | 4 |
| Kosobud, AE | 1 |
| Belknap, JK | 7 |
| Crabbe, JC | 8 |
| Kliethermes, CL | 1 |
| McMahon, LR | 1 |
| Javors, MA | 1 |
| France, CP | 2 |
| Kozell, L | 1 |
| Hofstetter, JR | 1 |
| Mayeda, A | 1 |
| Griffiths, RR | 5 |
| Ator, NA | 3 |
| Lukas, SE | 1 |
| Lamb, RJ | 2 |
| Brady, JV | 2 |
| Wei, ET | 2 |
| Sivam, SP | 1 |
| Nabeshima, T | 2 |
| Ho, IK | 9 |
| Emmett-Oglesby, M | 1 |
| Spencer, D | 1 |
| Lewis, M | 1 |
| Elmesallamy, F | 1 |
| Lal, H | 2 |
| Emmett-Oglesby, MW | 1 |
| Spencer, DG | 1 |
| Lewis, MW | 1 |
| Okamoto, M | 12 |
| Aaronson, L | 1 |
| Hinman, D | 1 |
| Hinman, DJ | 2 |
| Hillbom, ME | 1 |
| Hjelm-Jäger, M | 1 |
| Snell, D | 1 |
| Martin, WR | 4 |
| McNicholas, LF | 3 |
| Luttinger, D | 1 |
| Frye, GD | 1 |
| Bissette, G | 1 |
| Cherian, S | 1 |
| Valdman, AV | 1 |
| Zvartau, EE | 1 |
| Aaronson, LM | 1 |
| Epstein, RS | 1 |
| Roberts, AJ | 1 |
| Keith, LD | 1 |
| Woolverton, WL | 2 |
| Massey, BW | 1 |
| Winger, G | 2 |
| Patrick, GA | 4 |
| Harris, LS | 2 |
| Fujikawa, K | 1 |
| Akiyama, Y | 1 |
| Takayama, S | 1 |
| Sannerud, CA | 1 |
| Miyaoka, T | 1 |
| Kimura, T | 1 |
| Saunders, PA | 2 |
| Tseng, YT | 1 |
| Rabbani, M | 1 |
| Brown, J | 1 |
| Butterworth, AR | 1 |
| Little, HJ | 1 |
| Patrick, SJ | 1 |
| Snelling, LK | 1 |
| Ment, LR | 1 |
| Evans, EB | 1 |
| Balster, RL | 1 |
| Lin, LH | 1 |
| Wang, LH | 1 |
| Yutrzenka, GJ | 6 |
| Stone, T | 1 |
| Anderson, S | 1 |
| Matz, R | 1 |
| Wellman, SE | 1 |
| Jang, CG | 2 |
| Spanagel, R | 1 |
| Kirschke, C | 1 |
| Tretter, F | 1 |
| Holsboer, F | 1 |
| Kesavulu, V | 1 |
| Costarino, AT | 1 |
| Fonsmark, L | 1 |
| Rasmussen, YH | 1 |
| Carl, P | 1 |
| Phillips, TJ | 1 |
| Cunningham, CL | 1 |
| Zhu, H | 1 |
| Buck, K | 1 |
| Belknap, J | 1 |
| Crabbe, J | 1 |
| Gerak, LR | 1 |
| Nader, MA | 1 |
| Woods, JH | 2 |
| Hood, HM | 1 |
| Sivilotti, ML | 1 |
| Burns, MJ | 1 |
| Aaron, CK | 1 |
| Greenberg, MJ | 1 |
| Strickholm, A | 1 |
| Risberg, AM | 1 |
| Risberg, J | 1 |
| Ingvar, DH | 1 |
| Katz, J | 1 |
| Catravas, GN | 1 |
| Contreras, E | 1 |
| Tamayo, L | 1 |
| Quijada, L | 1 |
| Martin, BR | 1 |
| Dewey, WL | 1 |
| Chau-Pham, T | 1 |
| Prnage, AJ | 1 |
| Teggin, AF | 1 |
| Bewley, TH | 2 |
| Franks, RD | 1 |
| Jones, MA | 1 |
| Spratto, GR | 1 |
| Rosenberg, HC | 5 |
| Boisse, NR | 5 |
| Frederickson, RC | 2 |
| Slater, IH | 1 |
| Dusenberry, WE | 1 |
| Hewes, CR | 2 |
| Jones, GT | 1 |
| Moore, RA | 1 |
| Pack, RL | 1 |
| Ferko, AP | 1 |
| Buice, RG | 1 |
| Bourn, WM | 1 |
| Murano, T | 1 |
| Senda, H | 1 |
| Yamamoto, H | 1 |
| Yano, I | 1 |
| Chang, YY | 1 |
| Jones, BE | 2 |
| Prada, JA | 1 |
| Ritzmann, RF | 1 |
| Tabakoff, B | 1 |
| Aiken, JW | 1 |
| Tseng, LF | 1 |
| Loh, HH | 1 |
| Banerjee, U | 2 |
| Suzuki, T | 5 |
| Koike, Y | 5 |
| Yanaura, S | 4 |
| George, FR | 2 |
| Meisch, RA | 2 |
| Reynen, M | 1 |
| Dupuis, RE | 1 |
| Miranda-Massari, J | 1 |
| Ito, Y | 1 |
| Baker, ML | 1 |
| Hume, AS | 1 |
| Merrill, C | 1 |
| Rosenberger, W | 2 |
| Otani, K | 1 |
| Yoshii, T | 2 |
| Kosse, K | 1 |
| Lamb, R | 1 |
| Bigelow, GE | 1 |
| Roache, JD | 1 |
| Gmerek, DE | 1 |
| Dykstra, LA | 1 |
| Chida, Y | 1 |
| Misawa, M | 1 |
| Kuwahara, A | 2 |
| Kubota, A | 2 |
| Hakkei, M | 2 |
| Nakamura, K | 2 |
| Rao, S | 1 |
| Walewski, JL | 1 |
| Sandoval, MR | 1 |
| Palermo-Neto, J | 1 |
| Sullivan, JT | 1 |
| Sellers, EM | 1 |
| Kaim, SC | 1 |
| Cicero, TJ | 1 |
| Meyer, ER | 1 |
| Bell, RD | 1 |
| Stevenson, IH | 2 |
| Turnbull, MJ | 2 |
| Scanlon, JW | 1 |
| Kissin, B | 1 |
| Gross, MM | 1 |
| Kales, A | 1 |
| Bixler, EO | 1 |
| Tan, TL | 1 |
| Scharf, MB | 1 |
| Kales, JD | 1 |
| Shulman, A | 1 |
| Sargant, W | 1 |
| Raft, DD | 1 |
| Newmark, C | 1 |
| Toomey, T | 1 |
| Distasio, C | 1 |
| Nawrot, M | 1 |
| Nurimoto, S | 1 |
| Kamei, C | 1 |
| Shimomura, K | 1 |
| Ueki, S | 1 |
| Fraser, HF | 1 |
| Kreek, MJ | 1 |
| Schecter, A | 1 |
| Gutjahr, CL | 1 |
| Bowen, D | 1 |
| Field, F | 1 |
| Queenan, J | 1 |
| Merkatz, I | 1 |
| Inaba, DS | 1 |
| Ray, GR | 1 |
| Newmeyer, JA | 1 |
| Whitehead, C | 1 |
| Thompson, T | 1 |
| Gray, GR | 1 |
| Smith, DE | 2 |
| Wesson, DR | 2 |
| Sheppard, CW | 1 |
| Ben-Arie, O | 1 |
| Wikler, A | 1 |
| Urbaitis, JC | 1 |
| Essig, CF | 1 |
| Lam, RC | 1 |
| Jaffe, JH | 1 |
| Sharpless, SK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessing Current Analgesia and Sedation Weaning Practices in Adult Critically Ill Patients[NCT04422808] | 2,437 participants (Actual) | Observational | 2021-06-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for pentobarbital and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Barbiturate tolerance and physical dependence: contribution of pharmacological factors.
Topics: Anesthesia; Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Drug Administ | 1984 |
Identifying genes for alcohol and drug sensitivity: recent progress and future directions.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Chromosome Mapping; Cocaine; Crosses, Genet | 1999 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
Certain theoretical and practical considerations involved in evaluating the overall abuse potential of opiate agonists and antagonists.
Topics: Animals; Chlorpromazine; Codeine; Cyclazocine; Drug Combinations; Drug Evaluation; Drug Evaluation, | 1973 |
2 trials available for pentobarbital and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Effects of promethazine on nocturnal sleep in normal man.
Topics: Adult; Clinical Trials as Topic; Female; Humans; Male; Pentobarbital; Placebos; Promethazine; Sleep; | 1975 |
Prevention of delirium tremens: use of phenothiazines versus drugs cross-dependent with alcohol.
Topics: Antipsychotic Agents; Biogenic Amines; Brain Chemistry; Chlordiazepoxide; Chlorpromazine; Drug Toler | 1974 |
125 other studies available for pentobarbital and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines.
Topics: Alcohol Drinking; Animals; Avoidance Learning; Behavior, Animal; Benzodiazepines; Ethanol; Female; F | 2015 |
Cocaine withdrawal enhances pentobarbital-induced sleep in rats: evidence of GABAergic modulation.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Drug Synergism; G | 2008 |
Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.
Topics: Animals; Area Under Curve; Behavior, Animal; Brain; Chromosome Mapping; Chromosomes, Human, Pair 1; | 2009 |
Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice.
Topics: Animals; Barbiturates; Ethanol; Excitatory Amino Acid Agonists; Ibotenic Acid; Male; Mice; Pentobarb | 2011 |
Cerebral salt wasting syndrome in traumatic brain injury following therapeutic barbiturate coma.
Topics: Brain Injuries; Coma; Humans; Hypnotics and Sedatives; Hyponatremia; Inappropriate ADH Syndrome; Int | 2011 |
[Behavioral correlations of gradual forced administration of psychoactive drugs].
Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Dexamethasone; Dose-Response Relationship, Drug; Dr | 2011 |
Pentobarbital withdrawal and treatment in an infant in the pediatric cardiac intensive care unit.
Topics: Critical Care; Humans; Hypnotics and Sedatives; Infant; Intensive Care Units, Pediatric; Male; Pento | 2013 |
Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats.
Topics: Animals; Base Sequence; DNA Primers; Drug Tolerance; Heterotrimeric GTP-Binding Proteins; Liver; Mal | 2002 |
Progesterone withdrawal increases the anxiolytic actions of gaboxadol: role of alpha4betadelta GABA(A) receptors.
Topics: Animals; Anti-Anxiety Agents; Drug Implants; Female; GABA Agonists; Hippocampus; Ion Channels; Isoxa | 2003 |
CONVULSIONS IN A PILOT FOLLOWING DRUG WITHDRAWAL.
Topics: Aerospace Medicine; Diazepam; Drug Therapy; Meprobamate; Pentobarbital; Psychoses, Substance-Induced | 1965 |
TIMING OF OVULATION FOLLOWING PROGESTERONE WITHDRAWAL IN THE RAT.
Topics: Barbiturates; Endocrinology; Female; Humans; Luteinizing Hormone; Morphine; Organ Size; Ovary; Ovula | 1965 |
IDENTIFICATION AND TREATMENT OF BARBITURATE ABUSERS.
Topics: Barbiturates; Diagnosis; Drug Therapy; Drug Tolerance; Pentobarbital; Substance Withdrawal Syndrome; | 1965 |
NARCOTIC DRUG ADDICTION: ONE YEAR'S EXPERIECES AT PILGRIM STATE HOSPITAL.
Topics: Drug Therapy; Hepatitis; Homosexuality; Hospitals, Psychiatric; Hospitals, State; Humans; Legislatio | 1965 |
Potential pleiotropic effects of Mpdz on vulnerability to seizures.
Topics: Amino Acid Motifs; Animals; Carrier Proteins; Chromosome Mapping; Convulsants; Ethanol; Female; gamm | 2004 |
Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants | 2004 |
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relatio | 2007 |
Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2-23.3.
Topics: Acute Disease; Alcohol Withdrawal Seizures; Alcoholism; Animals; Chromosome Mapping; Chromosomes, Ma | 2008 |
Benzodiazepines: drug discrimination and physiological dependence.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Bromazepam; Diazepam; Discrimination Lear | 1984 |
Pharmacological aspects of shaking behavior produced by TRH, AG-3-5, and morphine withdrawal.
Topics: Animals; Cold Temperature; Escape Reaction; Humans; Morphine Dependence; Naloxone; Pentobarbital; Py | 1981 |
Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: a study with muscimol.
Topics: Animals; Brain; Drug Tolerance; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred ICR; Musci | 1982 |
Anxiogenic aspects of diazepam withdrawal can be detected in animals.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Discrimination Learning; Flumazenil; Humans; Male; Pe | 1983 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimina | 1984 |
Comparison of effects of diazepam on barbiturate and on ethanol withdrawal.
Topics: Animals; Behavior, Animal; Cats; Diazepam; Disease Models, Animal; Ethanol; Female; Humans; Male; Pe | 1983 |
Effects of individual variations in drug elimination kinetics for production of pentobarbital physical dependence.
Topics: Animals; Cats; Central Nervous System; Depression, Chemical; Female; Half-Life; Humans; Kinetics; Ma | 1983 |
Should alcohol withdrawal seizures be treated with anti-epileptic drugs?
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Carbamazepine; Chlormethiazol | 1984 |
Impairment of avoidance behavior following short-term ingestion of ethanol, tertiary-butanol, or pentobarbital in mice.
Topics: Animals; Avoidance Learning; Body Temperature; Butanols; Electroshock; Ethanol; Humans; Male; Mice; | 1980 |
Benzodiazepine dependence studies in rodents.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Humans; Pentobarbital; Rats; Self Administration; | 1980 |
Effects of neurotensin on the actions of barbiturates and ethanol.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Humans; Mice; | 1982 |
Diazepam and pentobarbital dependence in the rat.
Topics: Animals; Diazepam; Female; Humans; Pentobarbital; Rats; Rats, Inbred Strains; Substance Withdrawal S | 1982 |
Systems of reinforcement and drug dependence.
Topics: Amphetamines; Animals; Cats; Chlordiazepoxide; Cocaine; Diazepam; Drug Tolerance; Escape Reaction; E | 1982 |
Pharmacological responses to pentobarbital in different strains of mice.
Topics: Animals; Electron Transport; Half-Life; Humans; Male; Mice; Microsomes, Liver; Pentobarbital; Sleep; | 1981 |
Comparison of ethanol and barbiturate physical dependence.
Topics: Alcoholism; Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Dose-Response | 1981 |
Withdrawal symptoms from chronic use of low-dose barbiturates.
Topics: Female; Hallucinations; Humans; Middle Aged; Pentobarbital; Phenobarbital; Substance Withdrawal Synd | 1980 |
Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Diazepam; Ethanol; Female; Flumazenil; Handling, Psycholo | 1994 |
Evaluation of the abuse liability of aminorex.
Topics: Aminorex; Animals; Arousal; Dextroamphetamine; Discrimination Learning; Female; Infusions, Intraveno | 1994 |
Drug dependence study of the new cognition-enhancing agent nefiracetam in rats.
Topics: Animals; Body Weight; Codeine; Male; Morphine; Pentobarbital; Psychotropic Drugs; Pyrrolidinones; Ra | 1994 |
Behavioral pharmacology of tandospirone in baboons: chronic administration and withdrawal, self-injection and drug discrimination.
Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Cocaine; Discrimination Learning; Dose-Response Re | 1993 |
Binding characteristics of [3H]flunitrazepam in pentobarbital-withdrawal rats.
Topics: Animals; Cell Membrane; Cerebral Ventricles; Chlorides; Cholic Acids; Flunitrazepam; Frontal Lobe; I | 1994 |
Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal.
Topics: Anesthesia, General; Animals; Ataxia; Barbiturates; Bicuculline; Calcium Channels; Carbolines; Dihyd | 1994 |
Infantile chorea following abrupt withdrawal of diazepam and pentobarbital therapy.
Topics: Cardiac Catheterization; Chorea; Diazepam; Humans; Infant; Magnetic Resonance Imaging; Male; Pentoba | 1993 |
Inhaled 1,1,1-trichloroethane-produced physical dependence in mice: effects of drugs and vapors on withdrawal.
Topics: Administration, Inhalation; Animals; Chlorpromazine; Ethanol; Male; Mice; Midazolam; Pentobarbital; | 1993 |
Behavioral effects of pentobarbital, lorazepam, ethanol and chlorpromazine substitution in pentobarbital-dependent baboons.
Topics: Animals; Behavior, Animal; Chlorpromazine; Ethanol; Lorazepam; Male; Papio; Pentobarbital; Substance | 1993 |
Region-specific changes in GABAA receptor delta subunit mRNA level by tolerance to and withdrawal from pentobarbital.
Topics: Animals; Base Sequence; Drug Tolerance; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Molec | 1996 |
Ro 15-4513 alteration of pentobarbital dependence.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Male; Pentoba | 1996 |
Alcohol withdrawal syndrome.
Topics: Alcohol Withdrawal Delirium; Barbital; Humans; Hypnotics and Sedatives; Pentobarbital; Substance Wit | 1997 |
Changes in [3H]forskolin binding to adenylate cyclase and [3H]phorbol dibutyrate binding to protein kinase C in pentobarbital tolerant/dependent rats.
Topics: Adenylyl Cyclases; Animals; Brain; Cerebral Ventricles; Colforsin; Drug Tolerance; Infusions, Parent | 1998 |
Changes in NMDAR2 subunit mRNA levels during pentobarbital tolerance/withdrawal in the rat brain: an in situ hybridization study.
Topics: Animals; Brain; Drug Tolerance; GABA Modulators; In Situ Hybridization; Male; Pentobarbital; Peptide | 1998 |
Forced opiate withdrawal under anaesthesia augments and prolongs the occurrence of withdrawal signs in rats.
Topics: Anesthesia, General; Animals; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Neurologic | 1998 |
Pediatric sedation withdrawal: recognizing the need for refinement in a necessary therapy.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Critical Care; Dose-Response Relationship, | 1999 |
Occurrence of withdrawal in critically ill sedated children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Critical Care; Dose-Response Relationship, | 1999 |
Autoradiography of [3H]glutamate binding during pentobarbital tolerance and withdrawal in the rat.
Topics: Animals; Autoradiography; Brain; Drug Tolerance; Glutamic Acid; Hypnotics and Sedatives; Male; Pento | 1999 |
Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11.
Topics: Animals; Chromosome Mapping; Ethanol; Female; Genetic Linkage; Likelihood Functions; Mice; Mice, Inb | 1999 |
Genetic determinants of severity of acute withdrawal from diazepam in mice: commonality with ethanol and pentobarbital.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Diazepam; Ethanol; Hypnotics and S | 1999 |
Changes of [3H]muscimol binding and GABA(A) receptor beta2-subunit mRNA level by tolerance to and withdrawal from pentobarbital in rats.
Topics: Animals; Autoradiography; Brain; Cerebellum; Drug Tolerance; Frontal Lobe; Gene Expression Regulatio | 1999 |
Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Discrimination Learning; Female; Flunitrazepam; GABA | 2001 |
Genomewide search for epistasis in a complex trait: pentobarbital withdrawal convulsions in mice.
Topics: Animals; Chromosome Mapping; Crosses, Genetic; Epistasis, Genetic; Female; Male; Mice; Mice, Inbred | 2001 |
Pentobarbital for severe gamma-butyrolactone withdrawal.
Topics: 4-Butyrolactone; Adult; Arousal; Autonomic Nervous System Diseases; Emergency Service, Hospital; Fem | 2001 |
Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene.
Topics: Alleles; Animals; Base Sequence; Carrier Proteins; Chromosome Mapping; Ethanol; Female; Genes; Genet | 2002 |
Drug interactions with nerve membrane components regulating ionic permeability: action of tetrodotoxin, procaine, pentobarbital, and ethanol.
Topics: Animals; Astacoidea; Axons; Cell Membrane Permeability; Electric Conductivity; Ethanol; Humans; Hydr | 1979 |
Cerebellar cGMP levels reduced by morphine and pentobarbital on a dose- and time-dependent basis.
Topics: Animals; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Mor | 1976 |
Partial inhibition of the abstinence syndrome in morphine tolerant-dependent mice following pharmacological denervation.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Behavior, Animal; Denervation; Drug Tolerance; Humans; Methy | 1978 |
Interactions of thyrotropin releasing hormone and morphine sulfate in rodents.
Topics: Analgesics; Animals; Apomorphine; Behavior, Animal; Body Weight; Chlorpromazine; Dronabinol; Humans; | 1977 |
Withdrawal treatment for barbiturate dependence.
Topics: Barbiturates; Drug Administration Schedule; Female; Humans; Male; Pentobarbital; Substance Withdrawa | 1979 |
The overtranquilized patient.
Topics: Humans; Pentobarbital; Phenobarbital; Psychotherapy; Substance Withdrawal Syndrome; Substance-Relate | 1979 |
Ethanol suppression of naloxone-induced withdrawal in morphine-dependent rats.
Topics: Animals; Brain; Ethanol; Humans; Male; Morphine; Morphine Dependence; Naloxone; Pentobarbital; Rats; | 1977 |
Evaluation of anticonvulsants in barbiturate withdrawal.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cats; Dimethadione; Female; Humans; Male; Pentobarbital; | 1977 |
A comparison of thalidomide and pentobarbital - new methods for identifying novel hypnotic drugs.
Topics: Animals; Avoidance Learning; Canaries; Cats; Conditioning, Operant; Drug Evaluation, Preclinical; Hu | 1977 |
The effects of ethanol and pentobarbital on the naloxone precipitated escape response in morphine dependent mice.
Topics: Animals; Drug Interactions; Escape Reaction; Ethanol; Humans; Male; Mice; Morphine Dependence; Nalox | 1977 |
Barbiturate withdrawal syndrome in cats.
Topics: Animals; Behavior, Animal; Cats; Depression, Chemical; Humans; Motor Activity; Pentobarbital; Seizur | 1977 |
Time course of audiogenic seizure susceptibility and plasma pentobarbital concentration during withdrawal.
Topics: Acoustic Stimulation; Animals; Electroencephalography; Humans; Male; Pentobarbital; Rats; Seizures; | 1978 |
Physical dependence to barbital compared to pentobarbital. III. Withdrawal characteristics.
Topics: Animals; Barbital; Barbiturates; Cats; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substan | 1978 |
Physical dependence to barbital compared to pentobarbital. IV. Influence of elimination kinetics.
Topics: Animals; Barbital; Barbiturates; Cats; Humans; Kinetics; Pentobarbital; Peritoneal Dialysis; Substan | 1978 |
Loss of inhibition in the spinal cord during barbiturate withdrawal.
Topics: Action Potentials; Animals; Barbiturates; Cats; Female; Humans; Male; Neural Inhibition; Pentobarbit | 1978 |
Studies on the physical dependence potential of analgesics.
Topics: Adrenal Cortex; Animals; Chlorpromazine; Humans; Levallorphan; Male; Mice; Mitochondria; Morphine; M | 1978 |
Effects of acute and chronic administration of pentobarbital on catecholamine uptake in mouse brain synaptosomes.
Topics: Animals; Brain; Catecholamines; Drug Tolerance; Humans; In Vitro Techniques; Male; Mice; Mice, Inbre | 1979 |
A method for bioassay of physical dependence on sedative drugs in dog.
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Humans; Hypnotics and Sedatives; Methaqualone; Pentobar | 1976 |
Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence.
Topics: Animals; Behavior, Animal; Body Temperature; Diet; Drug Tolerance; Ethanol; Humans; Male; Mice; Mice | 1976 |
Electrophysiology of barbiturate withdrawal in the spinal cord.
Topics: Animals; Blood Pressure; Cats; Electric Stimulation; Electrophysiology; Female; Humans; Male; Pentob | 1976 |
Correlation between the in vivo and an in vitro expression of opiate withdrawal precipitated by naloxone: their antagonism by l-(-)-delta9-tetrahydrocannabinol.
Topics: Acetylcholine; Animals; Chlorpromazine; Codeine; Dose-Response Relationship, Drug; Dronabinol; Femal | 1976 |
Withdrawal characteristics following chronic pentobarbital dosing.
Topics: Animals; Cats; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders | 1976 |
Effects of clonidine on morphine withdrawal signs in the rat.
Topics: Anesthesia; Animals; Body Temperature; Cerebral Ventricles; Clonidine; Escape Reaction; Exophthalmos | 1975 |
Conditioned avoidance behavior in pretrained rats intermittently treated with addictive drugs.
Topics: Amphetamine; Animals; Avoidance Learning; Body Weight; Conditioning, Operant; Dose-Response Relation | 1975 |
Sex differences in physical dependence on pentobarbital in four inbred strains of rats.
Topics: Animals; Female; Male; Pentobarbital; Postural Balance; Rats; Rats, Inbred F344; Rats, Inbred SHR; R | 1992 |
Diltiazem alters some withdrawal signs in pentobarbital-dependent rats.
Topics: Animals; Calcium Channels; Diltiazem; Drug Synergism; Male; Pentobarbital; Rats; Rats, Inbred Strain | 1991 |
Pentobarbital tolerance and withdrawal: correlation with effects on the GABAA receptor.
Topics: Animals; Drug Tolerance; Male; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substan | 1990 |
Acute dependence on depressant drugs is determined by common genes in mice.
Topics: Acetaldehyde; Animals; Butanols; Ethanol; Injections, Intraperitoneal; Male; Mice; Pentobarbital; Se | 1991 |
Substitution of temazepam and midazolam in pentobarbital-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred St | 1989 |
Intensity of the withdrawal syndrome varies with duration of pentobarbital administration.
Topics: Animals; Male; Pentobarbital; Random Allocation; Rats; Rats, Inbred Strains; Substance Withdrawal Sy | 1989 |
Induction of physical dependence on pentobarbital by new infusion method in the rat.
Topics: Animals; Behavior, Animal; Drug Tolerance; Female; Infusion Pumps; Infusions, Intravenous; Male; Pen | 1989 |
Dependence on phenobarbital but not pentobarbital using drug-adulterated food.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Food Contamination; Male; M | 1989 |
Progress report from the Division of Behavioral Biology, the Johns Hopkins University School of Medicine.
Topics: Animals; Drug Tolerance; Humans; Male; Maryland; Papio; Pentobarbital; Research; Self Administration | 1986 |
Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats.
Topics: Animals; Arousal; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Pentobarbital; Pyr | 1986 |
Kappa opioids in rhesus monkeys. III. Dependence associated with chronic administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; B | 1987 |
Cross-physical dependence of several drugs in methaqualone-dependent rats.
Topics: Animals; Barbital; Diazepam; Ethanol; Male; Methaqualone; Pentobarbital; Postural Balance; Psychomot | 1988 |
Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats.
Topics: Animals; Behavior, Animal; Body Weight; Female; Genetics, Behavioral; Pentobarbital; Rats; Rats, Inb | 1987 |
[Drug dependence test on a cerebral insufficiency improver, aniracetam].
Topics: Animals; Brain; Cocaine; Drug Evaluation, Preclinical; Macaca fascicularis; Male; Memory; Methamphet | 1987 |
Effect of dosing frequency on the development of physical dependence and tolerance to pentobarbital.
Topics: Animals; Cats; Central Nervous System; Drug Administration Schedule; Drug Tolerance; Female; Half-Li | 1986 |
GABAergic influences on barbital withdrawal induced convulsions.
Topics: Animals; Barbital; Barbiturates; Corpus Striatum; gamma-Aminobutyric Acid; Male; Pentobarbital; Rats | 1986 |
[Drug dependence tests on a new anesthesia inducer, midazolam].
Topics: Animals; Injections, Intravenous; Macaca fascicularis; Male; Midazolam; Pentobarbital; Self Administ | 1986 |
Treatment of the barbiturate abstinence syndrome.
Topics: Barbiturates; Drug Administration Schedule; Drug Tolerance; Humans; Pentobarbital; Phenobarbital; Su | 1986 |
Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat.
Topics: Animals; Barbiturates; Disease Models, Animal; Humans; Injections, Intraperitoneal; Male; Motor Acti | 1985 |
Sex differences in the induction of physical dependence on pentobarbital in the rat.
Topics: Animals; Body Weight; Circadian Rhythm; Female; Male; Motor Activity; Pentobarbital; Postural Balanc | 1985 |
Effects of phenoxybenzamine on the narcotic withdrawal syndrome in the rat.
Topics: Adrenergic beta-Antagonists; Animals; Behavior, Animal; Body Weight; Chlorpromazine; Depression, Che | 1974 |
A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs.
Topics: Aging; Amphetamine; Animals; Anti-Anxiety Agents; Barbiturates; Body Weight; Carbon Radioisotopes; C | 1974 |
Letter: Pentazocine and neonatal withdrawal symptoms.
Topics: Female; Glutethimide; Humans; Infant, Newborn; Infant, Newborn, Diseases; Long-Term Care; Maternal-F | 1974 |
Drug therapy in alcoholism.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox | 1970 |
Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence.
Topics: Adult; Age Factors; Aged; Amobarbital; Chloral Hydrate; Chronic Disease; Dreams; Drug Therapy, Combi | 1974 |
The pharmacology of barbiturates.
Topics: Barbiturates; Bemegride; Central Nervous System; Central Nervous System Stimulants; Drug Tolerance; | 1970 |
Safety of combined antidepressant drugs.
Topics: Antidepressive Agents; Dibenzazepines; Drug Synergism; Hallucinations; Humans; Male; Pentobarbital; | 1971 |
The organic brain syndrome.
Topics: Alcoholic Intoxication; Attention; Chlordiazepoxide; Delirium; Haloperidol; Humans; Hydrocephalus; M | 1974 |
Programmed self-administration of potentially addictive drugs in young rats and its effects on learning.
Topics: Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Drug Tolerance; Ethanol; Extinction, Psy | 1974 |
Methaqualone.
Topics: Adult; Drug and Narcotic Control; Humans; Japan; Methaqualone; Pentobarbital; Substance Withdrawal S | 1973 |
A simple method for evaluating physical dependence liability in rats.
Topics: Aminopyrine; Animals; Azepines; Body Weight; Codeine; Cyproheptadine; Dextropropoxyphene; Humans; Ma | 1973 |
Significance of withdrawal jumping response in predicting physical dependence in mice.
Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imip | 1973 |
Analyses of methadone and other drugs in maternal and neonatal body fluids: use in evaluation of symptoms in a neonate of mother maintained on methadone.
Topics: Adult; Amniotic Fluid; Body Fluids; Escherichia coli Infections; Female; Fetal Blood; Heroin Depende | 1974 |
Methaqualone abuse. "Luding out".
Topics: Adult; California; Cannabis; Counseling; Female; Heroin Dependence; Humans; Male; Methaqualone; Pent | 1973 |
Pentobarbital facilitated extinction: effects of different schedules of drug withdrawal.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Dose-Response Relationship, Drug; Extinction, Ps | 1974 |
Outpatient barbiturate withdrawal using phenobarbital.
Topics: Administration, Oral; Adolescent; Adult; Ambulatory Care; Amobarbital; Barbiturates; Community Healt | 1972 |
The sensitivity of the brain to barbiturate during chronic administration and withdrawal of barbitone sodium in the rat.
Topics: Animals; Barbiturates; Brain; Brain Chemistry; Carbon Isotopes; Drug Hypersensitivity; Drug Toleranc | 1970 |
A new method for treatment of barbiturate dependence.
Topics: Barbiturates; Chlordiazepoxide; Diazepam; Heroin; Humans; Meprobamate; Pentobarbital; Phenobarbital; | 1970 |
Physical dependence on heroin and pentobarbitone.
Topics: Adult; Heroin; Humans; Male; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorde | 1968 |
Diagnosis and treatment of drug dependence of the barbiturate type.
Topics: Adult; Barbiturates; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pentobarbital; Psyc | 1968 |
Barbiturate dependence.
Topics: Barbiturates; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders; Tim | 1969 |
The effect of pentobarbital on alcohol withdrawal in dogs.
Topics: Animals; Dogs; Ethanol; Female; Humans; Male; Pentobarbital; Psychoses, Alcoholic; Seizures; Substan | 1969 |
The rapid development of physical dependence on barbiturates.
Topics: Animals; Cats; Denervation; Humans; Pentobarbital; Pentylenetetrazole; Seizures; Substance Withdrawa | 1965 |