Page last updated: 2024-11-02

pentobarbital and Subarachnoid Hemorrhage

pentobarbital has been researched along with Subarachnoid Hemorrhage in 13 studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.

Research Excerpts

ExcerptRelevanceReference
" Induced pentobarbital coma for the management of increased intracranial pressure is one such intervention, required to maintain patient stability."7.69Therapeutic Intervention Scoring System used in the care of patients in pentobarbital-induced coma to determine nurse-patient ratios. ( Bucholz, RD; Gomez, CR; Malkoff, MD; Myles, GL; Perry, AG, 1996)
" Pentobarbital and verapamil produced concentration-dependent vasodilation in segments of middle cerebral artery of either control or exposed to experimental subarachnoid hemorrhage (SAH) cats precontracted with 5-hydroxytryptamine (5-HT, 10(-5) M) or K+ (75 mM), the potency to evoke relaxation being greater for verapamil than pentobarbital."7.67Interference of pentobarbital and verapamil with the reactivity of middle cerebral artery of cat exposed to experimental subarachnoid hemorrhage. ( Marín, J; Martinez-Aldama, J; Salaices, M, 1989)
" Induced pentobarbital coma for the management of increased intracranial pressure is one such intervention, required to maintain patient stability."3.69Therapeutic Intervention Scoring System used in the care of patients in pentobarbital-induced coma to determine nurse-patient ratios. ( Bucholz, RD; Gomez, CR; Malkoff, MD; Myles, GL; Perry, AG, 1996)
" Pentobarbital and verapamil produced concentration-dependent vasodilation in segments of middle cerebral artery of either control or exposed to experimental subarachnoid hemorrhage (SAH) cats precontracted with 5-hydroxytryptamine (5-HT, 10(-5) M) or K+ (75 mM), the potency to evoke relaxation being greater for verapamil than pentobarbital."3.67Interference of pentobarbital and verapamil with the reactivity of middle cerebral artery of cat exposed to experimental subarachnoid hemorrhage. ( Marín, J; Martinez-Aldama, J; Salaices, M, 1989)
"Seizures were detected in 19% (n = 110) of patients who underwent cEEG monitoring; the seizures were exclusively nonconvulsive in 92% (n = 101) of these patients."2.42Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. ( Claassen, J; Emerson, RG; Hirsch, LJ; Kowalski, RG; Mayer, SA, 2004)
"Ninety-two cerebral aneurysm cases treated by clipping under moderate hypothermia are reviewed."1.27Barbiturates for cerebral aneurysm surgery. A review of preliminary results. ( Beks, JW; Belopavlovic, M; Buchthal, A, 1985)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19908 (61.54)18.7374
1990's2 (15.38)18.2507
2000's1 (7.69)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Connolly, M2
Liou, R1
Vespa, P2
Hu, X2
SUZUKI, K1
KOREY, SR1
TERRY, RD1
Claassen, J1
Mayer, SA1
Kowalski, RG1
Emerson, RG1
Hirsch, LJ1
Tsuchiya, J1
Ito, Y1
Hino, T1
Ohashi, H1
Kunieda, T1
Sakata, K1
Myles, GL1
Malkoff, MD1
Perry, AG1
Bucholz, RD1
Gomez, CR1
Lavine, SD1
Masri, LS1
Levy, ML1
Giannotta, SL1
Marín, J1
Martinez-Aldama, J1
Salaices, M1
Hayashi, M2
Kobayashi, H1
Kawano, H1
Handa, Y1
Kabuto, M1
Belopavlovic, M1
Buchthal, A1
Beks, JW1
McIntyre, JW2
Miller, JD2
Weir, BK1
Dobson, D1
Yamamoto, S1
Yamamoto, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Trial of Nonconvulsive Electrographic Seizure Detection by Nurses in the Adult Neuro ICU Using a Panel of Quantitative EEG Trends[NCT02082873]20 participants (Actual)Observational2015-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for pentobarbital and Subarachnoid Hemorrhage

ArticleYear
Detection of electrographic seizures with continuous EEG monitoring in critically ill patients.
    Neurology, 2004, May-25, Volume: 62, Issue:10

    Topics: Adult; Aged; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Cohort Studies; Coma; Conscio

2004

Other Studies

12 other studies available for pentobarbital and Subarachnoid Hemorrhage

ArticleYear
Identification of an Intracranial Pressure (ICP) Response Function from Continuously Acquired Electroencephalographic and ICP Signals in Burst-Suppressed Patients.
    Acta neurochirurgica. Supplement, 2016, Volume: 122

    Topics: Adult; Aneurysm, Ruptured; Brain Injuries, Traumatic; Brain Waves; Electroencephalography; Female; G

2016
Characterization of Cerebral Vascular Response to EEG Bursts Using ICP Pulse Waveform Template Matching.
    Acta neurochirurgica. Supplement, 2016, Volume: 122

    Topics: Adult; Aneurysm, Ruptured; Brain Injuries, Traumatic; Brain Waves; Cerebrovascular Circulation; Elec

2016
STUDIES ON PROTEIN SYNTHESIS IN BRAIN MICROSOMAL SYSTEM.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Amino Acids; Biomedical Research; Brain; Brain Diseases; Brain Neoplasms; Dementia; Electrons; Ether

1964
Stress ulcer accompanying subarachnoid hemorrhage--a new rat model.
    The Japanese journal of surgery, 1983, Volume: 13, Issue:4

    Topics: Animals; Cimetidine; Diazepam; Disease Models, Animal; Gastric Mucosa; Male; Pentobarbital; Phenytoi

1983
Therapeutic Intervention Scoring System used in the care of patients in pentobarbital-induced coma to determine nurse-patient ratios.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 1996, Volume: 5, Issue:1

    Topics: Adult; Cerebrovascular Disorders; Coma; Female; Humans; Hypnotics and Sedatives; Intracranial Pressu

1996
Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection.
    Journal of neurosurgery, 1997, Volume: 87, Issue:6

    Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Aneurysm, Ruptured; Brai

1997
Interference of pentobarbital and verapamil with the reactivity of middle cerebral artery of cat exposed to experimental subarachnoid hemorrhage.
    General pharmacology, 1989, Volume: 20, Issue:2

    Topics: Animals; Cats; Cerebral Arteries; Female; Male; Pentobarbital; Potassium; Subarachnoid Hemorrhage; V

1989
The effects of local intraparenchymal pentobarbital on intracranial hypertension following experimental subarachnoid hemorrhage.
    Anesthesiology, 1987, Volume: 66, Issue:6

    Topics: Animals; Dogs; Hypothalamus, Posterior; Injections; Intracranial Pressure; Medulla Oblongata; Pentob

1987
Barbiturates for cerebral aneurysm surgery. A review of preliminary results.
    Acta neurochirurgica, 1985, Volume: 76, Issue:3-4

    Topics: Arterial Occlusive Diseases; Brain; Cerebral Angiography; Cerebrovascular Disorders; Hemodynamics; H

1985
Anaesthesia for cerebral angiography: cardiovascular and cerebrospinal fluid pressure observations in the monkey under pentobarbital-halothane anaesthesia.
    Canadian Anaesthetists' Society journal, 1969, Volume: 16, Issue:4

    Topics: Anesthesia, General; Animals; Blood Pressure; Catheterization; Cerebral Angiography; Cerebrospinal F

1969
Simulated subarachnoid haemorrhage in monkeys under pentobarbital-halothane anaesthesia, with particular reference to monitoring during cerebral angiography.
    Canadian Anaesthetists' Society journal, 1969, Volume: 16, Issue:6

    Topics: Acid-Base Equilibrium; Anesthesia, General; Animals; Blood Pressure; Body Temperature; Cerebral Angi

1969
[Acute intracranial hypertension].
    No to shinkei = Brain and nerve, 1971, Volume: 23, Issue:3

    Topics: Adult; Aged; Betamethasone; Blood Pressure; Brain Edema; Cerebrospinal Fluid; Chlorpromazine; Electr

1971