pentobarbital has been researched along with Sleep Initiation and Maintenance Disorders in 36 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ephedrine alkaloids-free Ephedra Herb extract (EFE) has been developed to eliminate the adverse effects caused by ephedrine alkaloid-induced sympathetic hyperactivation." | 5.48 | Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias. ( Amakura, Y; Goda, Y; Hakamatsuka, T; Hanawa, T; Hyuga, M; Hyuga, S; Kobayashi, Y; Maruyama, T; Odaguchi, H; Oshima, N; Takahashi, J; Takemoto, H; Uchiyama, N; Yamashita, T, 2018) |
| "Zopiclone is a useful drug for the treatment of sleep disturbances, not only because of its efficacy, but also because of its tolerability." | 2.65 | Comparative study of zopiclone and pentobarbitone as hypnotics. ( Mello de Paula, AJ, 1983) |
| "Zopiclone is a useful drug for the treatment of sleep disturbances, not only because of its efficacy, but also because of its tolerability." | 2.65 | Comparative study of zopiclone and pentobarbitone as hypnotics. ( Mello de Paula, AJ, 1982) |
| "Flurazepam was found to be effective in inducing and maintaining sleep over all treatment conditions." | 2.64 | Effectiveness of hypnotic drugs with prolonged use: flurazepam and pentobarbital. ( Bixler, EO; Kales, A; Kales, JD; Scharf, MB, 1975) |
| "To investigate the anti-insomnia effects of SSW and explore its possible mechanisms using preclinical models." | 1.91 | Network pharmacology and pharmacological evaluation for deciphering novel indication of Sishen Wan in insomnia treatment. ( Li, JC; Li, S; Li, Y; Wang, LX; Xue, R; Yu, JJ; Zhang, Y; Zhang, YZ; Zhao, Q, 2023) |
| "Insomnia is one of the most common sleep-related diseases." | 1.91 | Effect of Repeated Application of Flos Daturae on Sedative and Hypnotic in Mice. ( Chen, XQ; Li, CL; Ma, BM; Yi, HL, 2023) |
| "Pentobarbital was injected i." | 1.72 | Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its active ingredients under conditions of glycerol fatty acid ester as emulsifiers. ( Maki, Y; Makino, T; Ota, M; Xu, LY, 2022) |
| "Insomnia is the most common sleep disorder." | 1.56 | Hydroalcoholic Extract of Cuscuta Epithymum Enhances Pentobarbitalinduced Sleep: Possible Involvement of GABAergic System. ( Aghaei, A; Forouzanfar, F; Rakhshandeh, H; Vahedi, MM, 2020) |
| "Ephedrine alkaloids-free Ephedra Herb extract (EFE) has been developed to eliminate the adverse effects caused by ephedrine alkaloid-induced sympathetic hyperactivation." | 1.48 | Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias. ( Amakura, Y; Goda, Y; Hakamatsuka, T; Hanawa, T; Hyuga, M; Hyuga, S; Kobayashi, Y; Maruyama, T; Odaguchi, H; Oshima, N; Takahashi, J; Takemoto, H; Uchiyama, N; Yamashita, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (52.78) | 18.7374 |
| 1990's | 1 (2.78) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (22.22) | 24.3611 |
| 2020's | 8 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Sobhanifar, MA | 1 |
| Rashidi, R | 1 |
| Rajabian, A | 1 |
| Forouzanfar, F | 2 |
| Hasanpour, M | 1 |
| Iranshahi, M | 1 |
| Rakhshandeh, H | 2 |
| Hosseini, A | 1 |
| Ota, M | 1 |
| Maki, Y | 1 |
| Xu, LY | 1 |
| Makino, T | 1 |
| Wang, LX | 1 |
| Zhao, Q | 1 |
| Zhang, Y | 1 |
| Xue, R | 1 |
| Li, S | 1 |
| Li, Y | 2 |
| Yu, JJ | 1 |
| Li, JC | 1 |
| Zhang, YZ | 1 |
| Mu, K | 3 |
| Zhang, J | 5 |
| Feng, X | 3 |
| Zhang, D | 3 |
| Li, K | 4 |
| Li, R | 3 |
| Yang, P | 3 |
| Mao, S | 3 |
| Park, CW | 1 |
| Hong, KB | 1 |
| Suh, HJ | 1 |
| Ahn, Y | 1 |
| Li, CL | 1 |
| Chen, XQ | 1 |
| Yi, HL | 1 |
| Ma, BM | 1 |
| Lin, A | 1 |
| Shih, CT | 1 |
| Chu, HF | 1 |
| Chen, CW | 1 |
| Cheng, YT | 1 |
| Wu, CC | 1 |
| Yang, CCH | 1 |
| Tsai, YC | 1 |
| Zhang, XG | 1 |
| Wang, WN | 1 |
| Zhang, CS | 1 |
| Ma, GD | 1 |
| Li, JY | 1 |
| Qiao, H | 1 |
| Ye, X | 1 |
| Bai, X | 1 |
| He, J | 1 |
| Li, T | 1 |
| Zhang, W | 1 |
| Xu, J | 1 |
| Zhu, H | 1 |
| Zhang, L | 2 |
| Wang, G | 1 |
| He, Z | 1 |
| Zhao, Y | 1 |
| Xu, Y | 1 |
| Gao, Y | 1 |
| Takemoto, H | 1 |
| Takahashi, J | 1 |
| Hyuga, S | 1 |
| Odaguchi, H | 1 |
| Uchiyama, N | 1 |
| Maruyama, T | 1 |
| Yamashita, T | 1 |
| Hyuga, M | 1 |
| Oshima, N | 1 |
| Amakura, Y | 1 |
| Hakamatsuka, T | 1 |
| Goda, Y | 1 |
| Hanawa, T | 1 |
| Kobayashi, Y | 1 |
| Vahedi, MM | 1 |
| Aghaei, A | 1 |
| Wu, P | 1 |
| Ning, Y | 1 |
| Yan, X | 1 |
| Zhu, T | 1 |
| Ma, C | 1 |
| Liu, A | 1 |
| Zhang, C | 1 |
| Mao, X | 1 |
| Zhao, X | 1 |
| Liu, Z | 1 |
| Liu, B | 1 |
| Li, H | 1 |
| Bi, K | 1 |
| Jia, Y | 1 |
| Fang, XSh | 1 |
| Hao, JF | 1 |
| Zhou, HY | 1 |
| Zhu, LX | 1 |
| Wang, JH | 1 |
| Song, FQ | 1 |
| Wang, LE | 1 |
| Cui, XY | 1 |
| Cui, SY | 1 |
| Cao, JX | 1 |
| Zhang, YH | 1 |
| Zhang, QY | 1 |
| Bai, YJ | 1 |
| Zhao, YY | 1 |
| SCHMIDT, R | 1 |
| HAGENBUCHER, JT | 1 |
| KLEH, J | 1 |
| HINTON, JM | 1 |
| Linnoila, M | 1 |
| Erwin, CW | 1 |
| Brendle, A | 1 |
| Mello de Paula, AJ | 2 |
| Shibasaki, T | 1 |
| Yamada, K | 1 |
| Yamauchi, N | 1 |
| Imaki, T | 1 |
| Hotta, M | 1 |
| Demura, H | 1 |
| Ott, H | 1 |
| Doenicke, A | 1 |
| Abress, C | 1 |
| Fischl, R | 1 |
| Hemmerling, KG | 1 |
| Fichte, K | 1 |
| Kales, A | 2 |
| Kales, JD | 2 |
| Bixler, EO | 2 |
| Scharf, MB | 2 |
| Wolff, BB | 1 |
| Carranza-Acevedo, J | 1 |
| Velasco, M | 1 |
| Tan, TL | 1 |
| Almassy, A | 1 |
| Pattison, JH | 1 |
| Allen, RP | 1 |
| Sapienza, PL | 1 |
| Forrest, WH | 1 |
| Bellville, JW | 1 |
| Brown, BW | 1 |
| Johns, MW | 1 |
| Hepburn, M | 1 |
| Goodyear, MD | 1 |
| Shapiro, S | 1 |
| Slone, D | 1 |
| Lewis, GP | 1 |
| Jick, H | 1 |
| Pietrobono, P | 1 |
| Venchi, G | 1 |
| Scotti, A | 1 |
| Ledoux, G | 1 |
| Jacquet, J | 1 |
| Lehembre, P | 1 |
10 trials available for pentobarbital and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Efficacy and side effects of flunitrazepam and pentobarbital in severely insomniac patients.
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; Flunitrazepam; Hu | 1982 |
Comparative study of zopiclone and pentobarbitone as hypnotics.
Topics: Adult; Azabicyclo Compounds; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypnotic | 1983 |
Comparative study of zopiclone and pentobarbitone as hypnotics.
Topics: Adult; Azabicyclo Compounds; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypnotic | 1982 |
[Lormetazepam in preoperative sleeplessness. Dose dependance of the effect and comparison with 100 mg pentobarbital (author's transl)].
Topics: Adult; Anti-Anxiety Agents; Female; Humans; Lorazepam; Male; Middle Aged; Pentobarbital; Preoperativ | 1979 |
Effectiveness of hypnotic drugs with prolonged use: flurazepam and pentobarbital.
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Drug Evaluation; Electroencephalography; Flura | 1975 |
Evaluation of hypnotics in outpatients with insomnia using a questionnaire and a self-rating technique.
Topics: Acetaminophen; Adult; Aspirin; Clinical Trials as Topic; Female; Histamine H1 Antagonists; Humans; H | 1974 |
Hypnotic effect of methaqualone employing placebo responder elimination.
Topics: Adult; Clinical Trials as Topic; Female; Humans; Male; Methaqualone; Pentobarbital; Placebos; Sleep | 1970 |
Comparison of the hypnotic effectiveness of secobarbital, pentobarbital, methyprylon and ethchlorvynol.
Topics: Age Factors; Aged; Clinical Trials as Topic; Ethchlorvynol; Humans; Hypnotics and Sedatives; Pentoba | 1972 |
A double-blind comparison of methaqualone, pentobarbital and placebo in the management of insomnia.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Methaqualone; Middle Aged; Pentobarbita | 1966 |
The interaction of caffeine with pentobarbital as a nighttime hypnotic.
Topics: Caffeine; Coffee; Drug Interactions; Feeding Behavior; Female; Humans; Male; Middle Aged; Pentobarbi | 1972 |
26 other studies available for pentobarbital and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
The possible mechanism of
Topics: Animals; Brain-Derived Neurotrophic Factor; Datura stramonium; Hypnotics and Sedatives; Mice; Naloxo | 2023 |
Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its active ingredients under conditions of glycerol fatty acid ester as emulsifiers.
Topics: Animals; Caffeine; Esters; Fatty Acids; GABA Antagonists; Glycerol; Hypnotics and Sedatives; Mice; P | 2022 |
Network pharmacology and pharmacological evaluation for deciphering novel indication of Sishen Wan in insomnia treatment.
Topics: Animals; Hypnotics and Sedatives; Network Pharmacology; Pentobarbital; Rats; Serotonin; Sleep Initia | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sedative-hypnotic effects of Boropinol-B on mice via activation of GABAA receptors.
Topics: Animals; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Mice; Pentobarbital; Rats; Receptors, GAB | 2023 |
Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors.
Topics: Amylases; gamma-Aminobutyric Acid; Pentobarbital; Plant Extracts; Receptors, GABA; Sleep; Sleep Init | 2023 |
Effect of Repeated Application of Flos Daturae on Sedative and Hypnotic in Mice.
Topics: Animals; Hypnotics and Sedatives; Mice; Pentobarbital; Sleep; Sleep Initiation and Maintenance Disor | 2023 |
Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice.
Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Limosilactobacillus fermentum; Male; M | 2021 |
Expression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris.
Topics: Animals; Delta Sleep-Inducing Peptide; Humans; Mice; Pentobarbital; Pichia; Protein Domains; Recombi | 2017 |
Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system.
Topics: Adenosine; Alkaloids; Animals; Caffeine; Camellia; Drug Synergism; Hippocampus; Male; Mice; Pentobar | 2017 |
Sedative and hypnotic effects of supercritical carbon dioxide fluid extraction from Schisandra chinensis in mice.
Topics: Animals; Carbon Dioxide; Hypnotics and Sedatives; Mice; Pentobarbital; Schisandra; Sleep Initiation | 2016 |
Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias.
Topics: Alkaloids; Analgesics, Non-Narcotic; Animals; Animals, Outbred Strains; Anxiety; Arrhythmias, Cardia | 2018 |
Hydroalcoholic Extract of Cuscuta Epithymum Enhances Pentobarbitalinduced Sleep: Possible Involvement of GABAergic System.
Topics: Acetates; Animals; Cell Line; Cuscuta; Disease Models, Animal; Drug Synergism; GABA Modulators; GABA | 2020 |
Sedative and hypnotic effect of freeze-dried paeoniflorin and sini san freeze-dried powder in pentobarbital sodium-induced mice.
Topics: Animals; Benzoates; Bridged-Ring Compounds; Drugs, Chinese Herbal; Glucosides; Humans; Hypnotics and | 2014 |
Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.
Topics: Animals; Behavior, Animal; Cyclooctanes; Disease Models, Animal; Drug Synergism; Flumazenil; Fruit; | 2014 |
Pharmacological studies on the sedative-hypnotic effect of Semen Ziziphi spinosae (Suanzaoren) and Radix et Rhizoma Salviae miltiorrhizae (Danshen) extracts and the synergistic effect of their combinations.
Topics: Animals; Drug Synergism; Drugs, Chinese Herbal; Hypnotics and Sedatives; Male; Mice; Movement; Pento | 2010 |
Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Drug Synergism; Drug Therapy, Combi | 2010 |
[On the medical therapy of insomnia].
Topics: Health Services; Humans; Pentobarbital; Sleep Initiation and Maintenance Disorders; Sleep Wake Disor | 1962 |
Treatment of insomnia in geriatric patients: double-blind study with methyprylon and pentobarbital.
Topics: Double-Blind Method; Geriatrics; Humans; Hypnotics and Sedatives; Patients; Pentobarbital; Phenobarb | 1962 |
A comparison of the effects of six barbiturates and a placebo on insomnia and motility in psychiatric patients.
Topics: Barbiturates; Double-Blind Method; Female; Hexobarbital; Humans; Hypnotics and Sedatives; Male; Midd | 1963 |
Beta 1-adrenergic mechanism is involved in stress-induced increase in arousal.
Topics: Animals; Arousal; Atropine; Butoxamine; Corticotropin-Releasing Hormone; Hypothalamus; Male; Metopro | 1994 |
[Paradoxical sleep in depressed patients. Effects of methaqualone and pentobarbital].
Topics: Adult; Depression; Humans; Male; Methaqualone; Middle Aged; Pentobarbital; Sleep Initiation and Main | 1971 |
Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence.
Topics: Adult; Age Factors; Aged; Amobarbital; Chloral Hydrate; Chronic Disease; Dreams; Drug Therapy, Combi | 1974 |
Use of hypnotic drugs by hospital patients.
Topics: Adult; Aged; Amobarbital; Antipyrine; Barbiturates; Diphenhydramine; Female; Hospitalization; Humans | 1971 |
Clinical effects of hypnotics. II. An epidemiologic study.
Topics: Body Weight; Chloral Hydrate; Diphenhydramine; Female; Humans; Hypnotics and Sedatives; Male; Pentob | 1969 |
[On the use of a new derivative of benzodiazepines (Ro 4-5360) in the treatment of insomnia in pre-surgery patients].
Topics: Anxiety; Diazepam; Glutethimide; Humans; Pentobarbital; Preanesthetic Medication; Preoperative Care; | 1969 |
[Problems raised by the choice of a hypnotic, in open and closed psychiatric wards, while experimenting with Ro.4-5360].
Topics: Diazepam; Humans; Mental Disorders; Pentobarbital; Sleep Initiation and Maintenance Disorders | 1966 |