pentobarbital has been researched along with Sensitivity and Specificity in 24 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 7.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 3.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| "Oral pentobarbital is an effective and safe sedative for pediatric transthoracic echocardiography." | 1.36 | The efficacy and safety of oral pentobarbital sedation in pediatric echocardiography. ( Bernard, PK; Kimball, TR; Warden, CN, 2010) |
| " There were no significant adverse events in either cohort." | 1.36 | A comparison of the efficacy and safety of chloral hydrate versus inhaled anesthesia for sedating infants and toddlers for transthoracic echocardiograms. ( Calfin, D; Cohen, MS; Jobes, DR; Jones, LA; Montenegro, LM; Nicolson, SC; O'Neill, D, 2010) |
| "Decreased pain was correlated with increased motor activity for morphine and amphetamine, and with decreased activity for xylazine and acepromazine; dipyrone and indomethacin did not alter activity levels." | 1.31 | The formalin test in the mouse: a parametric analysis of scoring properties. ( Abbott, FV; Saddi, GM, 2000) |
| "Pentobarbital was eluted and derivatized for gas chromatography/mass spectrometry in positive ion chemical ionization mode." | 1.31 | Method for determination of pentobarbital in dry dog food by gas chromatography/mass spectrometry. ( Cui, W; Heller, DN; Lewis, KM, 2001) |
| "Pentobarbital is a sedative hypnotic which is used in the treatment of people suffering from anxiety related conditions and to manage elevated intracranial pressures and cerebral ischemia due to neurosurgical procedures." | 1.30 | Capillary electrophoresis stereoselective determination of R-(+)- and S-(-)-pentobarbital from serum using hydroxypropyl-gamma-cyclodextrin, solid-phase extraction and ultraviolet detection. ( Bartlett, MG; Srinivasan, K, 1997) |
| "Bilirubin interference was less than 10." | 1.30 | Comparison of the serum barbiturate fluorescence polarization immunoassay by the COBAS INTEGRA to a GC/MS method. ( Cannon, RD; Gock, SB; Jentzen, JJ; Wong, SH, 1999) |
| " For halothane, the dose-response curve showed an IC50 concentration of 1." | 1.29 | Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics. ( Franks, NP; Hall, AC; Lieb, WR, 1994) |
| " Cumulative dose-response curves for chlordiazepoxide were obtained before and during chronic chlordiazepoxide administration and during chronic saline administration." | 1.29 | Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity. ( Alastra, AJ; Cohen, C; Goldberg, SR; Marley, RJ; Sannerud, CA; Serdikoff, SL, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 11 (45.83) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warden, CN | 1 |
| Bernard, PK | 1 |
| Kimball, TR | 1 |
| Nicolson, SC | 1 |
| Montenegro, LM | 1 |
| Cohen, MS | 1 |
| O'Neill, D | 1 |
| Calfin, D | 1 |
| Jones, LA | 1 |
| Jobes, DR | 1 |
| Zilberman, MV | 1 |
| Naftalin, RJ | 1 |
| Afzal, I | 1 |
| Browning, JA | 1 |
| Wilkins, RJ | 1 |
| Ellory, JC | 1 |
| Du, SM | 1 |
| Liu, JS | 1 |
| Xiang, YH | 1 |
| Hyun, C | 1 |
| Filippich, LJ | 1 |
| Hughes, I | 1 |
| Iltis, I | 1 |
| Kober, F | 1 |
| Dalmasso, C | 1 |
| Lan, C | 1 |
| Cozzone, PJ | 1 |
| Bernard, M | 1 |
| Kersemans, V | 1 |
| De Spiegeleer, B | 1 |
| Mertens, J | 1 |
| Slegers, G | 1 |
| Boda, D | 1 |
| Kaszaki, J | 1 |
| Tálosi, G | 1 |
| Malviya, S | 1 |
| Voepel-Lewis, T | 1 |
| Tait, AR | 1 |
| Watcha, MF | 1 |
| Sadhasivam, S | 1 |
| Friesen, RH | 1 |
| Hall, AC | 1 |
| Lieb, WR | 1 |
| Franks, NP | 1 |
| Sannerud, CA | 1 |
| Marley, RJ | 1 |
| Serdikoff, SL | 1 |
| Alastra, AJ | 1 |
| Cohen, C | 1 |
| Goldberg, SR | 1 |
| Aguayo, LG | 1 |
| Alarcón, JM | 1 |
| Whittemore, ER | 1 |
| Yang, W | 1 |
| Drewe, JA | 1 |
| Woodward, RM | 1 |
| Srinivasan, K | 1 |
| Bartlett, MG | 1 |
| Alfonso, M | 1 |
| Arufe, MC | 1 |
| Durán, R | 1 |
| McKinley, BA | 1 |
| Parmley, CL | 1 |
| Bowen, CA | 1 |
| Grant, KA | 1 |
| Cannon, RD | 1 |
| Wong, SH | 1 |
| Gock, SB | 1 |
| Jentzen, JJ | 1 |
| Hyder, F | 1 |
| Renken, R | 1 |
| Kennan, RP | 1 |
| Rothman, DL | 1 |
| Saddi, GM | 1 |
| Abbott, FV | 1 |
| Yamamoto, K | 1 |
| Tamura, T | 1 |
| Imai, R | 1 |
| Yamamoto, M | 1 |
| Heller, DN | 1 |
| Lewis, KM | 1 |
| Cui, W | 1 |
| Cory-Slechta, DA | 1 |
| Pokora, MJ | 1 |
| Widzowski, DV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A New Method of Sublingual Tonometry to Assess Tissue Perfusion in Patients With COPD and Healthy Individuals[NCT01169506] | 66 participants (Actual) | Interventional | 2009-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pentobarbital and Sensitivity and Specificity
| Article | Year |
|---|---|
Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in children.
Topics: Adolescent; Age Factors; Analgesics, Opioid; Anesthetics, Dissociative; Child; Child, Preschool; Chl | 2007 |
23 other studies available for pentobarbital and Sensitivity and Specificity
| Article | Year |
|---|---|
The efficacy and safety of oral pentobarbital sedation in pediatric echocardiography.
Topics: Administration, Oral; Child, Preschool; Comorbidity; Conscious Sedation; Drug-Related Side Effects a | 2010 |
A comparison of the efficacy and safety of chloral hydrate versus inhaled anesthesia for sedating infants and toddlers for transthoracic echocardiograms.
Topics: Administration, Inhalation; Administration, Oral; Anesthetics, Inhalation; Child, Preschool; Chloral | 2010 |
How best to assure patient co-operation during a pediatric echocardiography examination?
Topics: Administration, Oral; Child, Preschool; Comorbidity; Conscious Sedation; Drug-Related Side Effects a | 2010 |
Effects of high pressure on glucose transport in the human erythrocyte.
Topics: Biological Transport; Blood Glucose; Computer Simulation; Erythrocytes; Glucose Transporter Type 1; | 2002 |
[Determination of 23 drugs by capillary gas chromatography].
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Hypnotics and Sedatives; Pentobar | 2004 |
The inhibitory effect of pentobarbitone on reverse transcription-PCR.
Topics: Animals; Artifacts; DNA; Dogs; Female; Pentobarbital; Reproducibility of Results; Reverse Transcript | 2005 |
In vivo assessment of myocardial blood flow in rat heart using magnetic resonance imaging: effect of anesthesia.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Coronary Circulation; Disease Models, Anim | 2005 |
Influence of sedation and data acquisition method on tracer uptake in animal models: [123I]-2-iodo-L-phenylalanine in pentobarbital-sedated tumor-bearing athymic mice.
Topics: Animals; Artifacts; Cell Line, Tumor; Disease Models, Animal; Hypnotics and Sedatives; Image Interpr | 2006 |
A new simple tool for tonometric determination of the PCO2 in the gastrointestinal tract: in vitro and in vivo validation studies.
Topics: Anesthesia, General; Animals; Carbon Dioxide; Dogs; Gastrointestinal Tract; Injections, Intravenous; | 2006 |
Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics.
Topics: Administration, Inhalation; Anesthesia, General; Anesthetics; Animals; Calcium Channel Blockers; Cal | 1994 |
Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity.
Topics: Amphetamine; Animals; Behavior, Animal; Caffeine; Carbolines; Chlordiazepoxide; Chlorides; Chlorine; | 1993 |
Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol.
Topics: Aging; Animals; Barbiturates; Benzodiazepines; Bicuculline; Diazepam; Ethanol; GABA-A Receptor Antag | 1993 |
Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
Topics: Animals; Benzodiazepines; Binding Sites; Diazepam; Electrophysiology; Flumazenil; GABA Agonists; GAB | 1996 |
Capillary electrophoresis stereoselective determination of R-(+)- and S-(-)-pentobarbital from serum using hydroxypropyl-gamma-cyclodextrin, solid-phase extraction and ultraviolet detection.
Topics: Barbiturates; Circadian Rhythm; Cyclodextrins; Electrophoresis, Capillary; Hypnotics and Sedatives; | 1997 |
Validation of an EIA kit for determination of total thyroid hormones in rat serum. Effects of different anaesthetics.
Topics: Anesthetics; Animals; Glutamic Acid; Humans; Immunoenzyme Techniques; Ketamine; Male; Pentobarbital; | 1998 |
Effects of injury and therapy on brain parenchyma pO2, pCO2, pH and ICP following severe closed head injury.
Topics: Acid-Base Equilibrium; Adolescent; Adult; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cra | 1998 |
Increased specificity of ethanol's discriminative stimulus effects in an ethanol-pentobarbital-water discrimination in rats.
Topics: 2-Propanol; Animals; Anti-Infective Agents, Local; Behavior, Animal; Choice Behavior; Conditioning, | 1999 |
Comparison of the serum barbiturate fluorescence polarization immunoassay by the COBAS INTEGRA to a GC/MS method.
Topics: Barbiturates; Bilirubin; Fluorescence Polarization Immunoassay; Gas Chromatography-Mass Spectrometry | 1999 |
Quantitative multi-modal functional MRI with blood oxygenation level dependent exponential decays adjusted for flow attenuated inversion recovery (BOLDED AFFAIR).
Topics: Animals; Blood Flow Velocity; Body Water; Brain; Brain Mapping; Cerebrovascular Circulation; Echo-Pl | 2000 |
The formalin test in the mouse: a parametric analysis of scoring properties.
Topics: Acepromazine; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Ani | 2000 |
Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole.
Topics: Acute Disease; Anesthesia; Anesthetics, Inhalation; Animals; Astemizole; Atrioventricular Node; Cath | 2001 |
Method for determination of pentobarbital in dry dog food by gas chromatography/mass spectrometry.
Topics: Animal Feed; Animals; Biological Products; Dogs; Euthanasia; Food Analysis; Gas Chromatography-Mass | 2001 |
Postnatal lead exposure induces supersensitivity to the stimulus properties of a D2-D3 agonist.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Apomorphine; | 1992 |