pentobarbital has been researched along with Seizures in 273 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures." | 7.76 | Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice. ( Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 7.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| " after exposure to a soman dose of 4 x LD(50) completely terminated seizures with a moderate mortality rate (25%)." | 7.73 | Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| "To determine whether epidural pentobarbital (PB) delivery can prevent and/or terminate neocortical seizures induced by locally administered acetylcholine (Ach) in freely moving rats." | 7.73 | Epidural pentobarbital delivery can prevent locally induced neocortical seizures in rats: the prospect of transmeningeal pharmacotherapy for intractable focal epilepsy. ( Baptiste, SL; Devinsky, O; Doyle, WK; John, JE; Kuzniecky, RI; Ludvig, N; von Gizycki, H, 2006) |
| " Pentobarbitone administered after picrotoxin but without seizures resulted in an increase in both the intensity of Fos labeling and areal distribution of Fos-positive hilar astrocytes." | 7.69 | Pentobarbitone induces Fos in astrocytes: increased expression following picrotoxin and seizures. ( Hiscock, JJ; Mackenzie, L; Willoughby, JO, 1996) |
| "Pentobarbital and phenobarbital exhibited anticonvulsant effect against maximal electroshock (MES) and picrotoxin-induced seizures in rats." | 7.67 | Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. ( Mehta, AK; Ticku, MK, 1986) |
| "The interaction between pentobarbital and other modulators of GABAergic transmission (diazepam, ethanol and progabide) was investigated on maximal electroshock seizures and on the loss of righting reflexes in rats." | 7.67 | Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats. ( Rastogi, SK; Ticku, MK, 1985) |
| "We conducted a prospective study to examine the effect of pentobarbital administration on the development of seizures in dogs that had undergone cervical myelography with metrizamide while anesthetized with halothane." | 7.67 | Use of pentobarbital sodium to reduce seizures in dogs after cervical myelography with metrizamide. ( Gray, PR; Indrieri, RJ; Lowrie, CT, 1987) |
| "Status epilepticus is common in infants and may have long-term consequences on the brain persisting into adulthood." | 5.36 | Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus. ( Giorgi, FS; Hasson, H; Malhotra, S; Moshé, SL; Rosenbaum, DM, 2010) |
| "These data suggest that kainate-induced seizures cause alterations in APP RNA stability and/or processing in rat hippocampal neurons." | 5.28 | Amyloid precursor protein mRNA encoding the Kunitz protease inhibitor domain is increased by kainic acid-induced seizures in rat hippocampus. ( Baudry, M; Finch, CE; Johnson, SA; Najm, I; Pasinetti, GM; Tocco, G; Willoughby, DA, 1992) |
| "Seizures were repetitive and death occurred in 10." | 5.28 | Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats. ( David, J; Joseph, T; Kulkarni, C, 1992) |
| "Morphine was administered by the intracerebroventricular (i." | 5.27 | Morphine antagonizes pentobarbital-induced anesthesia. ( Carino, MA; Horita, A; Yamawaki, S, 1983) |
| "Repeated kindled seizures result in increased numbers of benzodiazepine receptors in fascia dentata membranes." | 5.27 | Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA). ( Fanelli, RJ; McNamara, JO, 1983) |
| "After onset of seizure an immediate, increasing perivascular acidosis developed which was accompanied by an increase in pial arterial diameter." | 5.26 | Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats. ( Kuschinsky, W; Wahl, M, 1979) |
| " The maximal electroshock test (MES) and pentylenetertrazole (PTZ)-induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium-induced sleeping time (PST) and locomotor activity in mice." | 3.81 | Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats. ( He, J; Lei, JP; Liao, DG; Liu, F; Liu, H; Luo, K; Song, Z; Yang, L; Zhang, TY; Zhuang, K, 2015) |
| "The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures." | 3.76 | Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice. ( Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| "This study compared the potencies of epidurally delivered muscimol, lidocaine, midazolam, pentobarbital and gamma-aminobutyric acid (GABA) to prevent focal neocortical seizures induced by locally applied acetylcholine (Ach), in rats (n=5)." | 3.76 | Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats. ( Baptiste, SL; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2010) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 3.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| " The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague Dawley rats." | 3.75 | A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. ( Friedman, D; Harden, CL; Maclusky, NJ; Malthankar-Phatak, GH; McCloskey, DP; Pearce, P; Scharfman, HE, 2009) |
| " Oral administration of beta-acids (5-10mg/kg) in rats produced an increased exploratory activity in the open field, a reduction in the pentobarbital hypnotic activity and a worsening of picrotoxin-induced seizures." | 3.74 | Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission. ( Avallone, R; Baraldi, M; Brusiani, F; Losi, G; Puia, G; Rivasi, M; Zanoli, P; Zavatti, M, 2007) |
| "To determine whether epidural pentobarbital (PB) delivery can prevent and/or terminate neocortical seizures induced by locally administered acetylcholine (Ach) in freely moving rats." | 3.73 | Epidural pentobarbital delivery can prevent locally induced neocortical seizures in rats: the prospect of transmeningeal pharmacotherapy for intractable focal epilepsy. ( Baptiste, SL; Devinsky, O; Doyle, WK; John, JE; Kuzniecky, RI; Ludvig, N; von Gizycki, H, 2006) |
| " after exposure to a soman dose of 4 x LD(50) completely terminated seizures with a moderate mortality rate (25%)." | 3.73 | Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| " A crude extract was given systemically and its effects were tested on pentylenetetrazole (PTZ)-induced seizures, sodium pentobarbital-induced hypnosis, exploratory activity, anxiety and nociception." | 3.73 | Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice. ( Carrera, D; Cedillo-Portugal, E; Gonzalez-Trujano, ME; Navarrete, A; Ventura-Martinez, R, 2006) |
| " Pharmacological effects were tested on ambulatory activity, anti-anxiety response, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced seizures in comparison to honokiol, buspirone, ethosuximide and diazepam as corresponding reference drugs." | 3.73 | Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. ( Chávez, M; Domínguez, F; González, M; González-Trujano, ME; Martínez, AL; Orozco, S; Salgado, H, 2006) |
| " The pharmacological properties of goodyerin were assayed for effects on spontaneous locomotor activity, on pentobarbital-induced hypnosis, and on anticonvulsant activity against picrotoxin-induced seizures in rodents." | 3.71 | Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana. ( Du, XM; Guo, YT; Shoyama, Y; Sun, NY; Takizawa, N, 2002) |
| " Pentobarbitone administered after picrotoxin but without seizures resulted in an increase in both the intensity of Fos labeling and areal distribution of Fos-positive hilar astrocytes." | 3.69 | Pentobarbitone induces Fos in astrocytes: increased expression following picrotoxin and seizures. ( Hiscock, JJ; Mackenzie, L; Willoughby, JO, 1996) |
| " serraefolia significantly delayed the onset of tonic seizures induced by strychnine and pentylenetetrazol; besides, it diminished the death rate and number of animals that exhibited convulsions." | 3.69 | Evaluation of the calcium-antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia. ( Aguilar-Santamaría, L; Tortoriello, J, 1996) |
| " Single seizures were induced with intravenous picrotoxin in unhandled animals housed in isolation." | 3.69 | Distribution of Fos-positive neurons in cortical and subcortical structures after picrotoxin-induced convulsions varies with seizure type. ( Hiscock, JJ; Mackenzie, L; Medvedev, A; Willoughby, JO, 1995) |
| " Pentobarbital given from start of overt seizures (30 to 60 mg/kg, IP, thrice daily) was able to stop convulsions and to antagonize processes involved in ischemia-induced neuronal death of CA1 hippocampus." | 3.69 | Neurologic and cytologic outcome following repeated ischemia. Effect of pentobarbital. ( Bralet, J; Marie, C; Mossiat, C, 1994) |
| " Acute nitrendipine significantly increased the latency of seizures in response to the partial benzodiazepine inverse agonist FG7142 during barbiturate withdrawal, but there was no effect on the seizure incidence in response to bicuculline." | 3.69 | Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal. ( Brown, J; Butterworth, AR; Little, HJ; Rabbani, M, 1994) |
| " Acute exposure to catnip increased stereotyped behavior and susceptibility to seizures, did not interfere with haloperidol-induced catalepsy, and decreased sleeping time after sodium pentobarbital administration." | 3.69 | Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice. ( Bernardi, MM; Gorniak, SL; Massoco, CO; Silva, MR; Spinosa, MS, 1995) |
| " The parameters studies included body weight, pentobarbitone (50 mg/kg) sleeping time, chlorpromazine (6 mg/kg) induced motor incoordination and convulsions induced by leptazol (100 mg/kg) and electrical stimulation (18 mA for 0." | 3.68 | Effect of subacute insecticide exposure on body weight, drug responses & electrical convulsions in mice. ( Agarwal, AK; Sankaranarayanan, A; Sharma, PL, 1990) |
| "Pentobarbital and phenobarbital exhibited anticonvulsant effect against maximal electroshock (MES) and picrotoxin-induced seizures in rats." | 3.67 | Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. ( Mehta, AK; Ticku, MK, 1986) |
| "Repeated administration of the beta-carboline benzodiazepine receptor ligand FG 7142 produces sensitization to its effects so that full seizures develop (chemical kindling); initially it is only pro-convulsant." | 3.67 | The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142. ( Little, HJ; Nutt, DJ; Taylor, SC, 1986) |
| "The interaction between pentobarbital and other modulators of GABAergic transmission (diazepam, ethanol and progabide) was investigated on maximal electroshock seizures and on the loss of righting reflexes in rats." | 3.67 | Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats. ( Rastogi, SK; Ticku, MK, 1985) |
| "Two strains of mice were shown to possess a differential sensitivity to picrotoxinin-induced convulsions; picrotoxinin elicited both tonic and clonic seizures at lower doses in the DBA/2J (DBA) strain compared to the BALB/c ByJ (BALB) strain." | 3.67 | Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding. ( Paul, SM; Schwartz, RD; Seale, TW; Skolnick, P, 1989) |
| "We conducted a prospective study to examine the effect of pentobarbital administration on the development of seizures in dogs that had undergone cervical myelography with metrizamide while anesthetized with halothane." | 3.67 | Use of pentobarbital sodium to reduce seizures in dogs after cervical myelography with metrizamide. ( Gray, PR; Indrieri, RJ; Lowrie, CT, 1987) |
| " Local coupling of blood flow and metabolism was studied under different types of anesthesia (barbiturate, halothane), following experimental tumor implantation, and during penicillin seizures or spreading depression." | 3.66 | A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats. ( Hossmann, KA; Mies, G; Niebuhr, I, 1981) |
| "Effects of intraventricular injection of sheep anti-somatostatin gamma-globulin (anti-SSG) on strychnine-induced seizures, strychnine LD50, and pentobarbital LD50 were examined in male rats under light ether anesthesia." | 3.66 | Effect of intraventricular administration of anti-somatostatin gamma-globulin on the lethal dose-50 of strychnine and pentobarbital in rats. ( Arimura, A; Chihara, K; Chihara, M; Schally, AV, 1978) |
| " Negative DRPs evoked by afferent nerve volleys are altered in waveform but not in amplitude during seizures induced by penicillin, although they are blocked by the administration of picrotoxin." | 3.65 | Functions of primary afferents and responses of extracellular K+ during spinal epileptiform seizures. ( Lothman, EW; Somjen, GG, 1976) |
| "2) Effective, seizures ceased but recurred with a decreased dose of PTB." | 2.68 | [Clinical study of pentobarbital treatment for status convulsivus in 14 children]. ( Kobayashi, K; Sato, M; Watanabe, T, 1996) |
| "Seizures were detected in 19% (n = 110) of patients who underwent cEEG monitoring; the seizures were exclusively nonconvulsive in 92% (n = 101) of these patients." | 2.42 | Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. ( Claassen, J; Emerson, RG; Hirsch, LJ; Kowalski, RG; Mayer, SA, 2004) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| "The high incidence of epileptic seizures in neonates and their frequent refractoriness to pharmacologic therapies require identification of new therapeutical options." | 1.51 | Taurine potentiates the anticonvulsive effect of the GABA ( Kilb, W; Luhmann, HJ; Winkler, P, 2019) |
| " LD50 of strychnine and hypnotic ED50 of pentobarbital sodium with or without theanine for mice were tested according to Bliss' case." | 1.43 | Theanine enhanced both the toxicity of strychnine and anticonvulsion of pentobarbital sodium. ( Gao, JC; Wu, BL; Yang, W; Yu, XC, 2016) |
| "The kainic acid (KA) model of induced seizures has been widely used to study temporal lobe epilepsy." | 1.40 | 3-Methyl-1-phenyl-2-pyrazolin-5-one or N-acetylcysteine prevents hippocampal mossy fiber sprouting and rectifies subsequent convulsive susceptibility in a rat model of kainic acid-induced seizure ceased by pentobarbital. ( Fukui, M; Miyamoto, R; Nomura, S; Shimakawa, S; Tamai, H, 2014) |
| "Hypothermia reduced seizure burden during and after treatment in all cases." | 1.39 | Hypothermia for pediatric refractory status epilepticus. ( Buttram, S; Guilliams, K; Miller, B; Pineda, J; Rosen, M; Shoykhet, M; Zempel, J, 2013) |
| "Chemical lesions did not affect convulsions in response to pentylenetetrazole, which blocks GABA(A) receptor-mediated transmission." | 1.37 | Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice. ( Buck, KJ; Chen, G; Kozell, LB, 2011) |
| "Status epilepticus is common in infants and may have long-term consequences on the brain persisting into adulthood." | 1.36 | Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus. ( Giorgi, FS; Hasson, H; Malhotra, S; Moshé, SL; Rosenbaum, DM, 2010) |
| "These compounds induced convulsions, urination and defecation in mice." | 1.31 | Neuropharmacological actions of some binuclear lanthanide(III) complexes. ( Howell, RC; Kahwa, IA; Williams, LA; Young, R, 2001) |
| "The interval until convulsion due to picrotoxin was also prolonged by the administration of DMP combined with diazepam and valproic acid (VPA)." | 1.31 | Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain. ( Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K, 2001) |
| "We conclude that the prolonged seizures of status epilepticus rapidly altered the functional properties of hippocampal dentate granule cell GABARs." | 1.30 | Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors. ( Kapur, J; Macdonald, RL, 1997) |
| "After 56 +/- 6 min a motor convulsion occurred, initially affecting the jaw, head and tail and variably extending to the forelimbs, trunk or hindlimbs." | 1.30 | Fos induction following systemic kainic acid: early expression in hippocampus and later widespread expression correlated with seizure. ( Hiscock, JJ; Mackenzie, L; Medvedev, A; Willoughby, JO, 1997) |
| " To provide loading and maintenance dosing for patients with hepatic induction secondary to concurrent anticonvulsants." | 1.30 | Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus. ( Chicella, MF; Dalton, JT; Eades, SK; Hovinga, CA; Phelps, SJ; Rose, DF, 1999) |
| "Potentially life-threatening seizures can occur following withdrawal from benzodiazepines, ethanol, or barbiturates." | 1.30 | Genetic determinants of severity of acute withdrawal from diazepam in mice: commonality with ethanol and pentobarbital. ( Crabbe, JC; Metten, P, 1999) |
| "Loreclezole is an anticonvulsant and anxiolytic compound which has been reported to potentiate GABA via a novel allosteric site on the beta-subunit of the receptor." | 1.29 | A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. ( Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF, 1996) |
| "Cypermethrin pretreatment potentiated the actions of pentobarbital and pentylene-tetrazole as evidenced by an increase in pentobarbital induced hypnosis and duration of pentylene-tetrazole induced chemoshock seizures." | 1.29 | Pharmacodynamic interactions of cypermethrin and centrally acting drugs in mice. ( Kanwar, RS; Varshneya, C, 1995) |
| "Although ineffective on the convulsion induced by picrotoxin (PT), it can prolong the latent period of convulsion induced by PT in mice." | 1.29 | [Central inhibition action of Valeriana jatamansii Jones]. ( Cao, B; Hong, GX, 1994) |
| "Naloxone was ineffective in antagonizing the analgesic effect of Rhazya stricta on tail-flick and abdominal constriction tests, possibly indicating that this effect occurs via non-opiate pathways." | 1.29 | Central nervous system activity of Rhazya stricta (Decne) in mice. ( Ali, BH; Banna, NR; Bashir, AK; Tanira, MO, 1995) |
| "These results suggest that withdrawal convulsions following acute ethanol, pentobarbital, and diazepam are sensitive to modulation by corticosterone and they support the hypothesis that stress may increase drug withdrawal severity." | 1.29 | Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice. ( Crabbe, JC; Keith, LD; Roberts, AJ, 1994) |
| "Withdrawal seizure prone (WSP) and withdrawal seizure resistant (WRS) mice were genetically selected to express severe or mild handling-induced convulsions (HIC), respectively, after cessation of chronic ethanol (EtOH) vapor inhalation." | 1.28 | Acute dependence on depressant drugs is determined by common genes in mice. ( Belknap, JK; Crabbe, JC; Merrill, C, 1991) |
| "For PTZ-induced convulsions, DN-2327, 0." | 1.28 | Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents. ( Fukuda, N; Wada, T, 1991) |
| "Seizures were repetitive and death occurred in 10." | 1.28 | Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats. ( David, J; Joseph, T; Kulkarni, C, 1992) |
| "Diazepam was antagonized by the benzodiazepine inverse agonists and by the neutral antagonist." | 1.28 | In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole. ( Ashton, D; Clincke, GH; Fransen, J; Heeres, J; Janssen, PA, 1992) |
| "Pa blocks the convulsions caused by pentylenetetrazole (PTZ) and increases motor activity when given alone in low doses." | 1.28 | Interaction of pregnanolone and pregnenolone sulfate with ethanol and pentobarbital. ( Allen, PM; Melchior, CL, 1992) |
| "These data suggest that kainate-induced seizures cause alterations in APP RNA stability and/or processing in rat hippocampal neurons." | 1.28 | Amyloid precursor protein mRNA encoding the Kunitz protease inhibitor domain is increased by kainic acid-induced seizures in rat hippocampus. ( Baudry, M; Finch, CE; Johnson, SA; Najm, I; Pasinetti, GM; Tocco, G; Willoughby, DA, 1992) |
| "ACTH4-7 pro-gly-pro decreased seizure threshold in the audiogenic epilepsy test, but did not prevent the motor convulsions." | 1.28 | [Anticonvulsive properties of peptide ACTH4-7 pro-gly-pro detected in amygdaloid kindling and audiogenic epilepsy in rats]. ( Artiukhova, MV; Chepurnov, SA; Chepurnova, NE; Kuznetsova, EIu; Nezavibat'ko, VN, 1989) |
| "Pentobarbital was also effective against bicuculline whereas only hypnotic doses of phenobarbital provided some protection against bicuculline- (8 mg/kg, IP) induced convulsions." | 1.27 | Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats. ( Mehta, AK; Ticku, MK, 1988) |
| " Male EC and IC rats did not differ in the CD50 (50% convulsion dosage by log probit analysis) following injection of a range of metrazol doses (20 to 35 mg/kg, IP) when they were kept in a quiet dimly lighted room." | 1.27 | Differential rearing affects responsiveness of rats to depressant and convulsant drugs. ( Conlee, JW; Greenough, WT; Juraska, JM, 1983) |
| "Morphine was administered by the intracerebroventricular (i." | 1.27 | Morphine antagonizes pentobarbital-induced anesthesia. ( Carino, MA; Horita, A; Yamawaki, S, 1983) |
| "Pentobarbital and diazepam were effective against both tonic and clonic seizure components induced by bicuculline and picrotoxin." | 1.27 | Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism. ( Rastogi, SK; Ticku, MK, 1986) |
| "Repeated kindled seizures result in increased numbers of benzodiazepine receptors in fascia dentata membranes." | 1.27 | Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA). ( Fanelli, RJ; McNamara, JO, 1983) |
| "Seizures and delirium tremens were recorded among 292 randomly selected patients admitted to an in-patient alcoholism program." | 1.27 | Should alcohol withdrawal seizures be treated with anti-epileptic drugs? ( Hillbom, ME; Hjelm-Jäger, M, 1984) |
| "While Metrazole still elicited seizures during this period, reinduction of c-fos was largely refractory." | 1.27 | Mapping patterns of c-fos expression in the central nervous system after seizure. ( Cohen, DR; Curran, T; Hempstead, JL; Morgan, JI, 1987) |
| " Animals were treated with Na pentobarbital according to the "maximally tolerable" dosing schedule described previously, twice a day for 35 days, and abruptly withdrawn." | 1.27 | Effects of individual variations in drug elimination kinetics for production of pentobarbital physical dependence. ( Hinman, DJ; Okamoto, M, 1983) |
| "Diazepam was selectively antagonized by RO15-1788." | 1.27 | Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB. ( Ashton, D, 1983) |
| " Groups of animals were treated with Na pentobarbital according to the "maximally tolerable" dosing schedule described previously, except that with different dose-frequency schedules, i." | 1.27 | Effect of dosing frequency on the development of physical dependence and tolerance to pentobarbital. ( Okamoto, M; Rao, S; Walewski, JL, 1986) |
| "The data suggest that overt convulsions may be necessary for the development of pentylenetetrazol-induced retrograde amnesia." | 1.26 | Pentylenetetrazol-induced amnesia: a case for overt seizures. ( Albala, B; Palfai, T, 1976) |
| "Phenytoin and diazepam were maximally effective at concentrations of 20 microgram/ml and 3-4 microgram/ml, respectively, in good agreement with their effective concentrations in clinical practice." | 1.26 | The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs. ( Hoffer, BJ; Oliver, AP; Wyatt, RJ, 1977) |
| "The occurrence of convulsions, during periods of complete reduction of the maintenance drug, became less frequent the longer the dogs had been maintained on a constant dose of sodium pentobarbital." | 1.26 | A method for bioassay of physical dependence on sedative drugs in dog. ( Jones, BE; Martin, WR; Prada, JA, 1976) |
| "Audiogenic seizure susceptibility and intensity peaked at 6 hours following the last dose, suggesting that a low concentration of barbiturate is more important in increasing seizure propensity than a sudden decrease in concentration." | 1.26 | Time course of audiogenic seizure susceptibility and plasma pentobarbital concentration during withdrawal. ( Bourn, WM; Buice, RG, 1978) |
| "Phenytoin was in effective for most withdrawal signs and some signs were made worse." | 1.26 | Evaluation of anticonvulsants in barbiturate withdrawal. ( Boisse, NR; Okamoto, M; Rosenberg, HC, 1977) |
| " At the highest (30 mg/kg) dosage of sodium pentobarbital, the spike frequency within the AD was decreased." | 1.26 | Hippocampal afterdischarges and their post-ictal sequelae in rats: a potential tool for assessment of CNS neurotoxicity. ( Annau, Z; Dyer, RS; Eccles, CU; Swartzwelder, HS, 1979) |
| "After onset of seizure an immediate, increasing perivascular acidosis developed which was accompanied by an increase in pial arterial diameter." | 1.26 | Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats. ( Kuschinsky, W; Wahl, M, 1979) |
| "For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s." | 1.26 | Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse. ( Blake, GJ; Gilbert, MB; Raines, A; Richardson, B, 1979) |
| " In all cases, data on plasma levels were subjected to pharmacokinetic analyses." | 1.26 | Carbamazepine pharmacokinetics in young, adult and pregnant rats. Relation to pharmacological effects. ( Assael, BM; Bossi, L; Garattini, S; Gerna, M; Gomeni, R; Morselli, PL, 1976) |
| " Principal features of the complex results include: double peaks in the time course of convulsion thresholds (Pc); an early peak and a shoulder in the time course of pressures reversing anesthesia (Pa); far steeper dose-response curves for Pa than for Pc; selectively greater anticonvulsant effect for phenobarbital than for the other barbiturates; and enhancement of Pa with simultaneous depression of Pc by reserpine in phenobarbital-pretreated mice." | 1.26 | Interaction of central nervous system effects of high pressures with barbiturates. ( Beaver, RW; Brauer, RW; Lahser, S, 1977) |
| "Protection against maximal electroshock convulsions, potentiation of pentobarbital sleeping-time and reduction of spontaneous motor activity were the effects measured." | 1.25 | Anticonvulsant activity of four oxygenated cannabidiol derivatives. ( Carlini, EA; Lander, N; Mechoulam, R, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 177 (64.84) | 18.7374 |
| 1990's | 45 (16.48) | 18.2507 |
| 2000's | 30 (10.99) | 29.6817 |
| 2010's | 21 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanawaku, Y | 1 |
| Hirakawa, K | 1 |
| Koike, K | 1 |
| Kanetake, J | 1 |
| Ohno, Y | 1 |
| Winkler, P | 1 |
| Luhmann, HJ | 1 |
| Kilb, W | 1 |
| Guilliams, K | 1 |
| Rosen, M | 1 |
| Buttram, S | 1 |
| Zempel, J | 1 |
| Pineda, J | 1 |
| Miller, B | 1 |
| Shoykhet, M | 1 |
| Nomura, S | 1 |
| Shimakawa, S | 1 |
| Miyamoto, R | 1 |
| Fukui, M | 1 |
| Tamai, H | 1 |
| Sorra, K | 1 |
| Chen, CS | 1 |
| Chang, CF | 1 |
| Pusuluri, S | 1 |
| Mukkanti, K | 1 |
| Wu, CR | 1 |
| Chuang, TH | 1 |
| Liu, H | 1 |
| Song, Z | 1 |
| Liao, DG | 1 |
| Zhang, TY | 1 |
| Liu, F | 1 |
| Zhuang, K | 1 |
| Luo, K | 1 |
| Yang, L | 2 |
| He, J | 1 |
| Lei, JP | 1 |
| Yu, XC | 1 |
| Wu, BL | 1 |
| Gao, JC | 1 |
| Yang, W | 1 |
| Adeoluwa, OA | 1 |
| Aderibigbe, AO | 1 |
| Agu, GO | 1 |
| Abdolmaleki, A | 1 |
| Moghimi, A | 1 |
| Ghayour, MB | 1 |
| Rassouli, MB | 1 |
| Luongo, R | 1 |
| Oliveira, DA | 1 |
| Lebrun, I | 1 |
| Sandoval, MR | 2 |
| Scharfman, HE | 1 |
| Malthankar-Phatak, GH | 1 |
| Friedman, D | 1 |
| Pearce, P | 1 |
| McCloskey, DP | 1 |
| Harden, CL | 1 |
| Maclusky, NJ | 1 |
| Hasson, H | 1 |
| Malhotra, S | 1 |
| Giorgi, FS | 1 |
| Rosenbaum, DM | 1 |
| Moshé, SL | 2 |
| Coppola, A | 1 |
| Baptiste, SL | 2 |
| Tang, HM | 1 |
| Kuzniecky, RI | 2 |
| Devinsky, O | 2 |
| French, JA | 1 |
| Ludvig, N | 2 |
| Watanabe, Y | 2 |
| Kaida, Y | 1 |
| Takechi, K | 1 |
| Kamei, C | 1 |
| Kikuchi, K | 1 |
| Hamano, S | 1 |
| Koichihara, R | 1 |
| Oritsu, T | 1 |
| Tanaka, M | 1 |
| Minamitani, M | 1 |
| Ida, H | 1 |
| Chen, G | 1 |
| Kozell, LB | 1 |
| Buck, KJ | 4 |
| Monforte, MT | 2 |
| Tzakou, O | 1 |
| Nostro, A | 1 |
| Zimbalatti, V | 1 |
| Galati, EM | 2 |
| Al-Khamees, WA | 1 |
| Schwartz, MD | 1 |
| Alrashdi, S | 1 |
| Algren, AD | 1 |
| Morgan, BW | 1 |
| Wu, XY | 1 |
| Zhao, JL | 1 |
| Zhang, M | 1 |
| Li, F | 1 |
| Zhao, T | 1 |
| Yang, LQ | 1 |
| Luo, J | 1 |
| Min, S | 1 |
| Wei, K | 1 |
| Li, P | 1 |
| Dong, J | 1 |
| Liu, YF | 1 |
| Herrera-Ruiz, M | 2 |
| Zamilpa, A | 1 |
| González-Cortazar, M | 1 |
| Reyes-Chilpa, R | 1 |
| León, E | 1 |
| García, MP | 1 |
| Tortoriello, J | 3 |
| Huerta-Reyes, M | 1 |
| Contó, MB | 1 |
| Hipólide, DC | 1 |
| de Carvalho, JG | 1 |
| Venditti, MA | 1 |
| Nugroho, A | 1 |
| Kim, MH | 1 |
| Choi, J | 1 |
| Choi, JS | 1 |
| Jung, WT | 1 |
| Lee, KT | 1 |
| Park, HJ | 1 |
| Trovato, A | 1 |
| Rossitto, A | 1 |
| Forestieri, AM | 1 |
| D'Aquino, A | 1 |
| Miceli, N | 1 |
| Du, XM | 1 |
| Sun, NY | 1 |
| Takizawa, N | 1 |
| Guo, YT | 1 |
| Shoyama, Y | 1 |
| Kasture, VS | 1 |
| Deshmukh, VK | 1 |
| Chopde, CT | 1 |
| Adzu, B | 1 |
| Amos, S | 1 |
| Muazzam, I | 1 |
| Inyang, US | 1 |
| Gamaniel, KS | 1 |
| Srivastava, VK | 1 |
| Kumar, A | 1 |
| Carvalho-Freitas, MI | 1 |
| Costa, M | 1 |
| Jones, DP | 1 |
| Lombroso, CT | 1 |
| BERNHARD, CG | 1 |
| BOHM, E | 1 |
| KIRSTEIN, L | 1 |
| WIESEL, T | 1 |
| PEARLMAN, CA | 1 |
| SHARPLESS, SK | 3 |
| JARVIK, ME | 1 |
| FRANK, GB | 1 |
| SANDERS, HD | 2 |
| PLOTNIKOFF, NP | 1 |
| LAYCOCK, GM | 1 |
| SHULMAN, A | 1 |
| ARENA, JM | 1 |
| MACHIYAMA, Y | 1 |
| HAMBURGER, E | 1 |
| NAKAJIMA, S | 1 |
| LISS, L | 1 |
| SOLZE, DA | 1 |
| FISCHER, R | 1 |
| KATO, R | 1 |
| VASSANELLI, P | 1 |
| FRONTINO, G | 1 |
| CHIESARA, E | 1 |
| BHATTACHARYA, SS | 1 |
| KISHOR, K | 1 |
| SAXENA, PN | 1 |
| BHARGAVA, KP | 1 |
| DAVANZO, JP | 1 |
| MATTHEWS, RJ | 1 |
| STAFFORD, JE | 1 |
| MOGENSON, GJ | 1 |
| DILLE, JR | 1 |
| TANG, PC | 1 |
| FLYNN, SF | 1 |
| HENDLEY, CD | 1 |
| SPUDIS, EV | 1 |
| DELATORRE, E | 1 |
| MORALES AGUILERA, A | 1 |
| VAUGHANWILLIAMS, EM | 1 |
| Fehr, C | 1 |
| Shirley, RL | 1 |
| Metten, P | 3 |
| Kosobud, AE | 1 |
| Belknap, JK | 5 |
| Crabbe, JC | 7 |
| Kliethermes, CL | 1 |
| Claassen, J | 1 |
| Mayer, SA | 1 |
| Kowalski, RG | 1 |
| Emerson, RG | 1 |
| Hirsch, LJ | 1 |
| Oliva, I | 1 |
| González-Trujano, ME | 3 |
| Arrieta, J | 1 |
| Enciso-Rodríguez, R | 1 |
| Navarrete, A | 2 |
| MIGLIARESE, JF | 1 |
| BAUER, EC | 1 |
| RANDALL, LO | 2 |
| Martínez, AL | 1 |
| Domínguez, F | 1 |
| Orozco, S | 1 |
| Chávez, M | 1 |
| Salgado, H | 1 |
| González, M | 1 |
| Carrera, D | 1 |
| Ventura-Martinez, R | 1 |
| Cedillo-Portugal, E | 1 |
| Myhrer, T | 1 |
| Enger, S | 1 |
| Aas, P | 1 |
| de Sousa, DP | 2 |
| de Sousa Oliveira, F | 1 |
| de Almeida, RN | 2 |
| Ha, JH | 1 |
| Lee, MG | 1 |
| Chang, SM | 1 |
| Lee, JT | 1 |
| Zanoli, P | 1 |
| Zavatti, M | 1 |
| Rivasi, M | 1 |
| Brusiani, F | 1 |
| Losi, G | 1 |
| Puia, G | 1 |
| Avallone, R | 1 |
| Baraldi, M | 1 |
| Vasconcelos, SM | 1 |
| Lima, NM | 1 |
| Sales, GT | 1 |
| Cunha, GM | 1 |
| Aguiar, LM | 1 |
| Silveira, ER | 1 |
| Rodrigues, AC | 1 |
| Macedo, DS | 1 |
| Fonteles, MM | 1 |
| Sousa, FC | 1 |
| Viana, GS | 1 |
| John, JE | 1 |
| von Gizycki, H | 1 |
| Doyle, WK | 1 |
| Duarte, FS | 1 |
| Duzzioni, M | 1 |
| Mendes, BG | 1 |
| Pizzolatti, MG | 1 |
| De Lima, TC | 1 |
| de Farias Nóbrega, FF | 1 |
| Uribe-Escamilla, R | 1 |
| Mota-Rojas, D | 1 |
| Sánchez-Aparicio, P | 1 |
| Alonso-Spilsbury, M | 1 |
| González-Piña, R | 1 |
| Alfaro-Rodríguez, A | 1 |
| Gutiérrez, C | 1 |
| Enrique Jiménez-Ferrer, J | 1 |
| Mirón, G | 1 |
| León, I | 1 |
| Wu, JK | 1 |
| Huo, JH | 1 |
| Du, XW | 1 |
| Sasaki, M | 1 |
| Matsuda, T | 1 |
| Watanabe, M | 1 |
| Okuaki, A | 1 |
| Takeda, M | 1 |
| Yoshimura, H | 1 |
| Tsukamoto, H | 1 |
| Straw, RN | 1 |
| Mitchell, CL | 1 |
| Pfeiffer, CJ | 1 |
| Muller, PJ | 1 |
| Macko, E | 1 |
| Wilfon, G | 1 |
| Greene, L | 1 |
| Bender, AD | 1 |
| Tedeschi, RE | 1 |
| Molnar, L | 1 |
| Seylaz, J | 1 |
| Fanelli, RJ | 1 |
| McNamara, JO | 1 |
| Ashton, D | 2 |
| Ogeto, JO | 1 |
| Juma, FD | 1 |
| Muriuki, G | 1 |
| Horita, A | 1 |
| Carino, MA | 1 |
| Yamawaki, S | 1 |
| Berry, AP | 1 |
| Arbuckle, JB | 1 |
| Nicol, J | 1 |
| Juraska, JM | 1 |
| Greenough, WT | 1 |
| Conlee, JW | 1 |
| Okamoto, M | 5 |
| Aaronson, L | 1 |
| Hinman, D | 1 |
| Hinman, DJ | 1 |
| Hillbom, ME | 1 |
| Hjelm-Jäger, M | 1 |
| Maly, P | 1 |
| Almén, T | 1 |
| Golman, K | 1 |
| Olivecrona, H | 1 |
| Andrews, PR | 1 |
| Mark, LC | 1 |
| Winkler, DA | 1 |
| Jones, GP | 1 |
| Doherty, T | 1 |
| Flint, BA | 1 |
| Ho, IK | 3 |
| Young, GB | 1 |
| Blume, WT | 1 |
| Bolton, CF | 1 |
| Warren, KG | 1 |
| Mies, G | 1 |
| Niebuhr, I | 1 |
| Hossmann, KA | 1 |
| Kiianmaa, K | 1 |
| von Boguslawsky, K | 1 |
| Kalichman, MW | 1 |
| Livingston, KE | 1 |
| Burnham, WM | 1 |
| Kryzhanovskiĭ, GN | 2 |
| Makul'kin, RF | 2 |
| Shandra, AA | 2 |
| Mayevsky, A | 1 |
| Shaya, B | 1 |
| Willoughby, JO | 3 |
| Mackenzie, L | 3 |
| Medvedev, A | 2 |
| Hiscock, JJ | 3 |
| Varshneya, C | 1 |
| Kanwar, RS | 1 |
| Ali, BH | 1 |
| Bashir, AK | 1 |
| Banna, NR | 1 |
| Tanira, MO | 1 |
| Groudine, SB | 1 |
| Cresanti-Daknis, C | 1 |
| Lumb, PD | 1 |
| Roberts, AJ | 1 |
| Keith, LD | 1 |
| Marie, C | 1 |
| Mossiat, C | 1 |
| Bralet, J | 1 |
| Cao, B | 1 |
| Hong, GX | 1 |
| Rabbani, M | 1 |
| Brown, J | 1 |
| Butterworth, AR | 1 |
| Little, HJ | 3 |
| Magloczky, Z | 1 |
| Freund, TF | 1 |
| McGarvey, KA | 1 |
| Zis, AP | 1 |
| Brown, EE | 1 |
| Nomikos, GG | 1 |
| Fibiger, HC | 1 |
| Darias, V | 1 |
| Abdallah, S | 1 |
| Delgado, L | 1 |
| Vega, S | 1 |
| Massoco, CO | 1 |
| Silva, MR | 1 |
| Gorniak, SL | 1 |
| Spinosa, MS | 1 |
| Bernardi, MM | 1 |
| Mitchell, WG | 1 |
| Aguilar-Santamaría, L | 1 |
| Kobayashi, K | 1 |
| Watanabe, T | 1 |
| Sato, M | 1 |
| Green, AR | 1 |
| Misra, A | 1 |
| Murray, TK | 1 |
| Snape, MF | 1 |
| Cross, AJ | 1 |
| Dasheiff, RM | 1 |
| Sacks, DS | 1 |
| Kapur, J | 1 |
| Macdonald, RL | 1 |
| Lemos, T | 1 |
| Cavalheiro, EA | 1 |
| Boothe, DM | 1 |
| Bastidas Ramírez, BE | 1 |
| Navarro Ruíz, N | 1 |
| Quezada Arellano, JD | 1 |
| Ruíz Madrigal, B | 1 |
| Villanueva Michel, MT | 1 |
| Garzón, P | 1 |
| Liao, JF | 1 |
| Huang, SY | 1 |
| Jan, YM | 1 |
| Yu, LL | 1 |
| Chen, CF | 1 |
| Wolfman, C | 1 |
| Viola, H | 1 |
| Marder, M | 1 |
| Ardenghi, P | 1 |
| Wasowski, C | 1 |
| Schröder, N | 1 |
| Izquierdo, I | 1 |
| Rúveda, E | 1 |
| Paladini, A | 1 |
| Medina, JH | 1 |
| Benardo, LS | 1 |
| Hovinga, CA | 1 |
| Chicella, MF | 1 |
| Rose, DF | 1 |
| Eades, SK | 1 |
| Dalton, JT | 1 |
| Phelps, SJ | 1 |
| Hatalski, CG | 1 |
| Brunson, KL | 1 |
| Tantayanubutr, B | 1 |
| Chen, Y | 1 |
| Baram, TZ | 1 |
| Williams, LA | 1 |
| Howell, RC | 1 |
| Young, R | 1 |
| Kahwa, IA | 1 |
| Hood, HM | 1 |
| Yamada, K | 1 |
| Aoyagi, Y | 1 |
| Ohta, A | 1 |
| Raines, A | 2 |
| Blake, GJ | 1 |
| Richardson, B | 1 |
| Gilbert, MB | 1 |
| Kuschinsky, W | 1 |
| Wahl, M | 1 |
| Mares, P | 2 |
| Kolínová, M | 2 |
| Lothman, EW | 1 |
| Somjen, GG | 1 |
| Chihara, K | 1 |
| Arimura, A | 1 |
| Chihara, M | 1 |
| Schally, AV | 1 |
| Hablitz, JJ | 1 |
| Wray, DV | 1 |
| Gal'dinov, GV | 1 |
| Kudriavtseva, NW | 1 |
| Sabelli, HC | 1 |
| Diamond, BI | 1 |
| May, J | 1 |
| Havdala, HS | 1 |
| Strömbom, U | 1 |
| Forn, J | 1 |
| Dolphin, AC | 1 |
| Greengard, P | 1 |
| Pellegrini, A | 1 |
| Musgrave, J | 1 |
| Gloor, P | 1 |
| Caron, M | 1 |
| LeLorier, J | 1 |
| Dyer, RS | 1 |
| Swartzwelder, HS | 1 |
| Eccles, CU | 1 |
| Annau, Z | 1 |
| Rosenberg, HC | 2 |
| Boisse, NR | 2 |
| Buice, RG | 1 |
| Bourn, WM | 1 |
| Oliver, AP | 1 |
| Hoffer, BJ | 2 |
| Wyatt, RJ | 1 |
| Helke, CJ | 1 |
| Landgren, S | 1 |
| Bäckström, T | 1 |
| Kalistratov, G | 1 |
| Mann, PA | 1 |
| Isom, GE | 1 |
| Sanders, B | 1 |
| Wylie, IG | 1 |
| Afshar, F | 1 |
| Koeze, TH | 1 |
| Palfai, T | 1 |
| Albala, B | 1 |
| Andersen, ME | 1 |
| Jones, RA | 1 |
| Kurlansik, L | 1 |
| Mehl, RG | 1 |
| Jenkins, LJ | 1 |
| Czerski, P | 1 |
| Seiger, A | 1 |
| Taylor, D | 1 |
| Olson, L | 1 |
| Freedman, R | 1 |
| Järbe, TU | 1 |
| Johansson, JO | 1 |
| Sterman, MB | 1 |
| Shouse, MN | 1 |
| Lucia, MC | 1 |
| Heinrich, RL | 1 |
| Sarnoff, SK | 1 |
| Beaver, RW | 1 |
| Brauer, RW | 1 |
| Lahser, S | 1 |
| Assael, BM | 1 |
| Bossi, L | 1 |
| Garattini, S | 1 |
| Gerna, M | 1 |
| Gomeni, R | 1 |
| Morselli, PL | 1 |
| Jones, BE | 2 |
| Prada, JA | 1 |
| Martin, WR | 1 |
| Turnbull, MJ | 2 |
| Watkins, JW | 1 |
| Zirvi, KA | 1 |
| Dar, MS | 2 |
| Fakouhi, T | 1 |
| Schwartzkroin, PA | 1 |
| Mutani, R | 1 |
| Prince, DA | 1 |
| Yamamoto, I | 1 |
| Loh, HH | 1 |
| Carlini, EA | 1 |
| Mechoulam, R | 1 |
| Lander, N | 1 |
| Stowe, CM | 1 |
| Werdin, RE | 1 |
| Barnes, DM | 1 |
| Higbee, J | 1 |
| Miller, J | 1 |
| Knoll, LW | 1 |
| Dayton, RM | 1 |
| Sittig, DC | 1 |
| Hayes, AW | 1 |
| Presley, DB | 1 |
| Neville, JA | 1 |
| Willoughby, DA | 1 |
| Johnson, SA | 1 |
| Pasinetti, GM | 2 |
| Tocco, G | 2 |
| Najm, I | 2 |
| Baudry, M | 3 |
| Finch, CE | 1 |
| Saunders, PA | 1 |
| Kimura, T | 1 |
| Miyaoka, T | 1 |
| Zeng, YC | 1 |
| Pezzola, A | 1 |
| Scotti De Carolis, A | 2 |
| Sagratella, S | 2 |
| Melchior, CL | 1 |
| Allen, PM | 1 |
| Kim, CK | 1 |
| Pinel, JP | 1 |
| Roese, NR | 1 |
| Fransen, J | 1 |
| Heeres, J | 1 |
| Clincke, GH | 1 |
| Janssen, PA | 1 |
| Kulkarni, C | 1 |
| Joseph, T | 1 |
| David, J | 1 |
| Dugich-Djordjevic, MM | 1 |
| Lapchak, PA | 1 |
| Hefti, F | 1 |
| Dolin, SJ | 1 |
| Smith, MB | 1 |
| Soar, J | 1 |
| Morris, PJ | 1 |
| Gautam, SK | 1 |
| Kulkarni, SK | 3 |
| Wada, T | 1 |
| Fukuda, N | 1 |
| Dupuis, RE | 1 |
| Miranda-Massari, J | 1 |
| Merrill, C | 1 |
| Petrali, JP | 1 |
| Maxwell, DM | 1 |
| Lenz, DE | 1 |
| Mills, KR | 1 |
| Agarwal, AK | 1 |
| Sankaranarayanan, A | 1 |
| Sharma, PL | 1 |
| Sakina, MR | 1 |
| Dandiya, PC | 1 |
| Hamdard, ME | 1 |
| Hameed, A | 1 |
| Muñoz-Blanco, J | 1 |
| Yusta, B | 1 |
| Martínez-Luque, M | 1 |
| González, JM | 1 |
| Suzuki, SS | 1 |
| Smith, GK | 1 |
| Schwartz, RD | 1 |
| Seale, TW | 1 |
| Skolnick, P | 1 |
| Paul, SM | 1 |
| Ticku, MK | 6 |
| Chepurnov, SA | 1 |
| Chepurnova, NE | 1 |
| Artiukhova, MV | 1 |
| Kuznetsova, EIu | 1 |
| Nezavibat'ko, VN | 1 |
| Asuzu, IU | 1 |
| Shetty, SN | 1 |
| Anika, SM | 1 |
| Young, ER | 1 |
| Suzuki, T | 1 |
| Otani, K | 1 |
| Koike, Y | 1 |
| Yoshii, T | 1 |
| Yanaura, S | 1 |
| Nutt, DJ | 3 |
| Taylor, SC | 2 |
| Standing, BL | 1 |
| Gale, RG | 1 |
| Mehta, AK | 2 |
| Lister, RG | 1 |
| Rastogi, SK | 2 |
| Olsen, RW | 1 |
| Wamsley, JK | 1 |
| McCabe, RT | 1 |
| Lee, RJ | 1 |
| Lomax, P | 1 |
| Niglio, T | 1 |
| Morgan, JI | 1 |
| Cohen, DR | 1 |
| Hempstead, JL | 1 |
| Curran, T | 1 |
| Frantík, E | 1 |
| Horváth, M | 1 |
| Vodicková, L | 1 |
| Gray, PR | 1 |
| Indrieri, RJ | 1 |
| Lowrie, CT | 1 |
| Rock, DM | 1 |
| Taylor, CP | 1 |
| Crawley, JN | 1 |
| Stivers, JA | 1 |
| Martin, JV | 1 |
| Mendelson, WB | 1 |
| Rao, S | 1 |
| Walewski, JL | 1 |
| Palermo-Neto, J | 1 |
| Marcillon, M | 1 |
| Blin, F | 1 |
| Marcotte, C | 1 |
| Dupont, MC | 1 |
| Lynch, G | 1 |
| Gall, C | 1 |
| Webster, CJ | 1 |
| Webster, JM | 1 |
| Kuga, T | 1 |
| Naito, J | 1 |
| Kaim, SC | 1 |
| Ferrini, R | 1 |
| Miragoli, G | 1 |
| Taccardi, B | 1 |
| Lebovitz, RM | 1 |
| Moyersoons, F | 1 |
| Evraerd, A | 1 |
| Dauby, J | 1 |
| Giurgea, C | 1 |
| Bazán, NG | 1 |
| Gupta, AK | 1 |
| Dwivedi, C | 1 |
| Gupta, TK | 2 |
| Parmar, SS | 2 |
| Cornatzer, WE | 1 |
| Bean, JW | 3 |
| Zee, D | 3 |
| Thom, B | 1 |
| Chiba, S | 1 |
| Nagawa, Y | 1 |
| Yui, T | 1 |
| Alderman, JL | 1 |
| Culver, BW | 1 |
| Shellenberger, MK | 1 |
| Cutright, DE | 1 |
| Nichols, WA | 1 |
| Kumar, R | 1 |
| Ali, B | 1 |
| Miller, KW | 2 |
| Henry, KR | 2 |
| Hohenauer, L | 1 |
| Willott, J | 1 |
| Bhattacharya, SK | 1 |
| Ghosal, S | 1 |
| Chaudhuri, RK | 1 |
| Sanyal, AK | 1 |
| Khanna, NK | 1 |
| Madan, BR | 1 |
| Mahatma, OP | 1 |
| Surana, SC | 1 |
| Praestholm, J | 1 |
| Reiter, RJ | 1 |
| Morgan, WW | 1 |
| Talbot, JA | 1 |
| Gehres, LD | 1 |
| Randall, CL | 1 |
| Riccio, DC | 1 |
| Vardaris, RM | 1 |
| Trivedi, CP | 1 |
| Sharma, RD | 1 |
| Gupta, L | 1 |
| Arora, RB | 1 |
| Singh, M | 1 |
| Singh, KP | 1 |
| Bhandari, DS | 1 |
| Kuenzel, WJ | 1 |
| Rubenstein, JB | 1 |
| Wright, DC | 1 |
| Crowell, RM | 1 |
| Wyss, FE | 2 |
| Fankhauser, H | 1 |
| Akert, K | 2 |
| Lever, MJ | 1 |
| Paton, WD | 1 |
| Smith, EB | 1 |
| Zbinden, G | 1 |
| De Jong, RH | 1 |
| Heavner, JE | 1 |
| Slater, P | 1 |
| Briggs, I | 1 |
| Dobkin, J | 1 |
| Buck, SH | 1 |
| Lage, GL | 1 |
| McIntyre, DC | 1 |
| Reichert, H | 1 |
| Mayse, JF | 1 |
| DeVietti, TL | 1 |
| Mercurio, JP | 1 |
| Woolley, DE | 2 |
| Shimamura, M | 1 |
| Yamauchi, T | 1 |
| Ahmad, A | 1 |
| Vohra, MM | 1 |
| Achari, G | 1 |
| Dadkar, NK | 1 |
| Damle, SK | 1 |
| Gaitonde, B | 1 |
| Shanbhag, SM | 1 |
| Kulkarni, HJ | 1 |
| Gaitonde, BB | 1 |
| Yoshino, Y | 3 |
| Elliott, KA | 3 |
| Christmas, AJ | 1 |
| Maxwell, DR | 1 |
| Hartung, R | 1 |
| Pittle, LB | 1 |
| Cornish, HH | 1 |
| Weinreich, D | 1 |
| Clark, LD | 1 |
| Hasegawa, AT | 1 |
| Landahl, HD | 1 |
| Downes, H | 1 |
| Perry, RS | 1 |
| Ostlund, RE | 1 |
| Karler, R | 1 |
| Doggett, NS | 1 |
| Spencer, PS | 1 |
| Waite, R | 1 |
| Harris, RE | 1 |
| Clark, R | 1 |
| Lynes, TE | 1 |
| Price, WA | 1 |
| Smith, DH | 1 |
| Woodward, JK | 1 |
| Marvel, JP | 1 |
| Vernier, VG | 1 |
| Iturrian, WB | 1 |
| Johnson, HD | 1 |
| White, RP | 1 |
| Rudolph, AS | 1 |
| Jindal, MN | 1 |
| Doctor, RB | 1 |
| Kelkar, VV | 1 |
| Choksey, HK | 1 |
| Prasad, S | 1 |
| Malhotra, CL | 1 |
| Nishie, K | 1 |
| Waiss, AC | 1 |
| Keyl, AC | 1 |
| Prichard, JW | 1 |
| Gallagher, BB | 1 |
| Glaser, GH | 1 |
| Essig, CF | 1 |
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| Jaffe, JH | 1 |
| Dietz, AJ | 1 |
| Burgison, RM | 1 |
| Levin, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Trial of Nonconvulsive Electrographic Seizure Detection by Nurses in the Adult Neuro ICU Using a Panel of Quantitative EEG Trends[NCT02082873] | 20 participants (Actual) | Observational | 2015-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for pentobarbital and Seizures
| Article | Year |
|---|---|
Why is the developing brain more susceptible to status epilepticus?
Topics: Animals; Animals, Newborn; Brain; Diazepam; Disease Models, Animal; Female; Humans; Male; Pentobarbi | 2009 |
Detection of electrographic seizures with continuous EEG monitoring in critically ill patients.
Topics: Adult; Aged; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Cohort Studies; Coma; Conscio | 2004 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
Inert gas narcosis and animals under high pressure.
Topics: Animals; Helium; Inert Gas Narcosis; Injections, Subcutaneous; Larva; Mice; Nitrogen; Pentobarbital; | 1972 |
Increased adult auditory responsiveness resulting from juvenile acoustic experience.
Topics: Acetates; Acoustic Stimulation; Anesthesia; Animals; Audiometry; Auditory Pathways; Auditory Thresho | 1973 |
Pharmacology of benzodiazepines: laboratory and clinical correlations.
Topics: Aggression; Alcoholism; Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Avoidance Learn | 1967 |
2 trials available for pentobarbital and Seizures
| Article | Year |
|---|---|
[Clinical study of pentobarbital treatment for status convulsivus in 14 children].
Topics: Child; Child, Preschool; Encephalitis; Epilepsy; Female; Humans; Hypnotics and Sedatives; Infant; Ma | 1996 |
Prevention of delirium tremens: use of phenothiazines versus drugs cross-dependent with alcohol.
Topics: Antipsychotic Agents; Biogenic Amines; Brain Chemistry; Chlordiazepoxide; Chlorpromazine; Drug Toler | 1974 |
263 other studies available for pentobarbital and Seizures
| Article | Year |
|---|---|
Pattern recognition analysis of proton nuclear magnetic resonance spectra of postmortem cerebrospinal fluid from rats with drug-induced seizure or coma.
Topics: Animals; Cerebrospinal Fluid; Coma; Convulsants; Discriminant Analysis; Hypnotics and Sedatives; Mag | 2017 |
Taurine potentiates the anticonvulsive effect of the GABA
Topics: Animals; Animals, Newborn; Anticonvulsants; Drug Synergism; GABA-A Receptor Agonists; Hippocampus; M | 2019 |
Hypothermia for pediatric refractory status epilepticus.
Topics: Adolescent; Child; Electroencephalography; Female; Humans; Hypothermia, Induced; Infant; Male; Pento | 2013 |
3-Methyl-1-phenyl-2-pyrazolin-5-one or N-acetylcysteine prevents hippocampal mossy fiber sprouting and rectifies subsequent convulsive susceptibility in a rat model of kainic acid-induced seizure ceased by pentobarbital.
Topics: Acetylcysteine; Aldehydes; Animals; Anticonvulsants; Antipyrine; Cell Survival; Edaravone; Excitator | 2014 |
Synthesis, anticonvulsant, sedative and anxiolytic activities of novel annulated pyrrolo[1,4]benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Exploratory Behavior; Heterocyclic | 2014 |
Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats.
Topics: Acorus; Animals; Anticonvulsants; Brain; Caspase 3; Disease Models, Animal; Electroshock; Epilepsy; | 2015 |
Theanine enhanced both the toxicity of strychnine and anticonvulsion of pentobarbital sodium.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Female; Glutam | 2016 |
Pharmacological Evaluation of Central Nervous System Effects of Ethanol Leaf Extract of Olax Subscorpioidea in Experimental Animals.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Eth | 2016 |
Evaluation of neuroprotective, anticonvulsant, sedative and anxiolytic activity of citicoline in rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Cytidine Diphosphate Choline; Hypno | 2016 |
Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Cell Death; Diazepam; Electroencephalogr | 2009 |
A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Estrous Cycle; Female; Pentobarbital; Pi | 2009 |
Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Infarction, Middle Cerebral Artery; Kainic Acid; Ma | 2010 |
Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats.
Topics: Acetylcholine; Animals; Anticonvulsants; Electrodes, Implanted; Electroencephalography; gamma-Aminob | 2010 |
Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice.
Topics: Animals; Anticonvulsants; Brain; Excitatory Amino Acid Antagonists; GABA Agents; Indans; Kindling, N | 2010 |
[Efficacy and safety of intravenous phenobarbital for status epilepticus and frequent seizures in children].
Topics: Adolescent; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; Pentobarbital; | 2010 |
Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice.
Topics: Animals; Barbiturates; Ethanol; Excitatory Amino Acid Agonists; Ibotenic Acid; Male; Mice; Pentobarb | 2011 |
Chemical composition and biological activities of Calamintha officinalis Moench essential oil.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Antifungal Agents; Artemia; Behavior, Animal; Body | 2011 |
Status epilepticus associated with borage oil ingestion.
Topics: Acyclovir; Adult; Anticonvulsants; Borago; Diethylcarbamazine; Drug Therapy, Combination; Female; ga | 2011 |
Sedative, hypnotic and anticonvulsant activities of the ethanol fraction from Rhizoma Pinelliae Praeparatum.
Topics: Animals; Anticonvulsants; Ethanol; Hypnotics and Sedatives; Locomotion; Mice; Mice, Inbred ICR; Nike | 2011 |
Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats.
Topics: Animals; Cognition; Depression; Down-Regulation; Electroconvulsive Therapy; Electroshock; gamma-Amin | 2011 |
Antidepressant effect and pharmacological evaluation of standardized extract of flavonoids from Byrsonima crassifolia.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Antidepressive Agents; Chromatography, High Pres | 2011 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepa | 2012 |
Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aster Plant; Chromatography, High Pressure Liquid; Disease Models, Animal; | 2012 |
Anticonvulsant and sedative effects of Salvadora persica L. stem extracts.
Topics: Animals; Anticonvulsants; Celastraceae; Drug Synergism; Female; Hypnotics and Sedatives; Lethal Dose | 2002 |
Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana.
Topics: Animals; Anticonvulsants; Convulsants; Disaccharides; Flavonoids; Flavonols; Glycosides; Hypnotics a | 2002 |
Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Brain Chemistry; Elect | 2002 |
Neuropharmacological screening of Diospyros mespiliformis in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diospyros; Dose-Response Relationship, Drug; Hypnotics a | 2002 |
Synthesis of newer thiadiazolyl and thiazolidinonyl quinazolin-4 3H-ones as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Syner | 2002 |
Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L.
Topics: Animals; Anti-Anxiety Agents; Citrus; Fruit; Hypnotics and Sedatives; Male; Mice; Oils, Volatile; Pe | 2002 |
Effect of metrazol and nembutal on motor activity in the spinal cat.
Topics: Animals; Barbiturates; Cats; Felis; Motor Activity; Pentobarbital; Pentylenetetrazole; Seizures; Spi | 1955 |
The difference in action on normal and convulsive cortical activity between a local anaesthetic (lidocaine) and barbiturates.
Topics: Anesthesia, Local; Anesthetics, Local; Barbiturates; Lidocaine; Pentobarbital; Phenobarbital; Seizur | 1956 |
Retrograde amnesia produced by anesthetic and convulsant agents.
Topics: Amnesia; Amnesia, Retrograde; Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthetics; Convulsa | 1961 |
A PROPOSED COMMON MECHANISM OF ACTION FOR GENERAL AND LOCAL ANAESTHETICS IN THE CENTRAL NERVOUS SYSTEM.
Topics: Action Potentials; Anesthesia, Local; Anesthetics, Local; Animals; Cats; Central Nervous System; Cer | 1963 |
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacol | 1963 |
PARTIAL AGONISTS IN THE CENTRAL NERVOUS SYSTEM.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Hypnotics and Sedatives; Mic | 1963 |
TREATMENT OF CONVULSIONS.
Topics: Amobarbital; Anticonvulsants; Ethanol; Humans; Paraldehyde; Pentobarbital; Phenytoin; Seizures; Succ | 1964 |
[COMPOSITION OF ACETYLCHOLINE IN THE MOUSE BRAIN AND ITS CHANGES UNDER VARIOUS PHYSIOLOGICAL CONDITIONS].
Topics: Acetylcholine; Anesthesia; Animals; Biochemical Phenomena; Biochemistry; Brain; Electric Stimulation | 1964 |
BARBITURATE USE IN NARCOTIC ADDICTS.
Topics: Barbiturates; Codeine; Drug Tolerance; Ethchlorvynol; Glutethimide; Heroin; Hydromorphone; Hypnotics | 1964 |
EFFECTS OF CHEMICAL INJECTION INTO THE RETICULAR FORMATION OF RATS.
Topics: Chlorides; Citrates; Coma; Fear; Injections; Nikethamide; Pentobarbital; Potassium; Procaine; Rats; | 1964 |
THE HISTOMORPHOLOGY OF EXPERIMENTAL EXCITATION.
Topics: Acridines; Coloring Agents; Depression; Depressive Disorder; Hippocampus; Histology; Lysergic Acid D | 1964 |
VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.
Topics: Aging; Animals, Newborn; Carisoprodol; Diphosphates; Hexobarbital; Insecticides; Liver; Meprobamate; | 1964 |
A NEUROPHARMACOLOGICAL STUDY OF GAMMA-AMINOBUTYRIC ACID (GABA).
Topics: Aminobutyrates; Anesthesia; Anesthesia, Intravenous; Behavior, Animal; Brain Chemistry; Cats; Chlorp | 1964 |
STUDIES ON THE MECHANISM OF ACTION OF AMINOOXYACETIC ACID. I. REVERSAL OF AMINOOXYACETIC ACID-INDUCED CONVULSIONS BY VARIOUS AGENTS.
Topics: Acetates; Acetone; Aldehydes; Aminooxyacetic Acid; Antidotes; Cats; Electroencephalography; Glycine; | 1964 |
EFFECTS OF SODIUM PENTOBARBITAL ON BRAIN SELF-STIMULATION.
Topics: Brain; Pentobarbital; Pharmacology; Rats; Research; Seizures; Self Stimulation; Sodium; Stereotaxic | 1964 |
CONVULSIONS IN A PILOT FOLLOWING DRUG WITHDRAWAL.
Topics: Aerospace Medicine; Diazepam; Drug Therapy; Meprobamate; Pentobarbital; Psychoses, Substance-Induced | 1965 |
INTRACRANIAL PRESSURE DURING ELECTROSHOCK CONVULSIONS IN THE DOG.
Topics: Blood Pressure; Blood Pressure Determination; Bradycardia; Cerebrovascular Circulation; Dogs; Electr | 1965 |
THE ACTION OF PRONETHALOL ON SPINAL REFLEXES.
Topics: Anesthetics; Anesthetics, Local; Blood Pressure; Electrophysiology; Electroshock; Ethanolamines; Gui | 1965 |
Potential pleiotropic effects of Mpdz on vulnerability to seizures.
Topics: Amino Acid Motifs; Animals; Carrier Proteins; Chromosome Mapping; Convulsants; Ethanol; Female; gamm | 2004 |
Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants | 2004 |
Neuropharmacological profile of hydroalcohol extract of Valeriana edulis ssp. procera roots in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, I | 2004 |
Prevention of procaine convulsions by presidon and sodium pentobarbital.
Topics: Biomedical Research; Pentobarbital; Procaine; Seizures; Sodium | 1950 |
Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; | 2006 |
Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Central Nervous System Depressants; Ethanol; | 2006 |
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Dipeptides; Drug Combinations; Lethal Dose 50; | 2006 |
Evaluation of the central activity of hydroxydihydrocarvone.
Topics: Analgesics; Analgesics, Opioid; Animals; Anticonvulsants; Central Nervous System Agents; Convulsants | 2006 |
In vivo characterization of sedative activities of Fossilia Mastodi OSSIS.
Topics: Animals; Diazepam; Fossils; Hypnotics and Sedatives; Male; Mammals; Mice; Mice, Inbred ICR; Motor Ac | 2006 |
Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission.
Topics: Animals; Antidepressive Agents; Binding, Competitive; Carbon Dioxide; Central Nervous System; Cerebe | 2007 |
Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu.
Topics: Administration, Oral; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Erythrina; Glycine | 2007 |
Epidural pentobarbital delivery can prevent locally induced neocortical seizures in rats: the prospect of transmeningeal pharmacotherapy for intractable focal epilepsy.
Topics: Acetylcholine; Animals; Anticonvulsants; Cerebrospinal Fluid; Disease Models, Animal; Drug Administr | 2006 |
Participation of dihydrostyryl-2-pyrones and styryl-2-pyrones in the central effects of Polygala sabulosa (Polygalaceae), a folk medicine topical anesthetic.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Anti-Anxiety Agents; Anxiety; Convulsants; Dio | 2007 |
Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study.
Topics: Analgesics; Animals; Behavior, Animal; Central Nervous System; Cyclohexane Monoterpenes; Male; Mice; | 2007 |
Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Disease Models, Animal; Drug Interactions; Electro | 2007 |
Central nervous system depressant activity of an ethyl acetate extract from Ipomoea stans roots.
Topics: Acetates; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Central Nervous Syst | 2007 |
[Pharmacological effects of volatile oil of Valeriana amurensis on CNS].
Topics: Animals; Central Nervous System; Central Nervous System Agents; Drug Synergism; Drugs, Chinese Herba | 2007 |
[Effect of diazepam pretreatment on convulsions induced by procaine].
Topics: Animals; Diazepam; Injections, Intraperitoneal; Pentobarbital; Procaine; Rats; Seizures | 1966 |
[Metabolism of drugs. LIV. On the pharmacological action of carbamate N-glucuronides].
Topics: Animals; Carbamates; Coma; Glucuronates; Male; Meprobamate; Mice; Pentobarbital; Rats; Seizures; Ure | 1966 |
A comparison of the effects of phenobarbital and pentobarbital on motor cortical threshold and righting reflex response in the cat.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Electrophysiology; Injections, Intraperitoneal; Inj | 1967 |
Physiologic correlates dependent upon mode of death.
Topics: Adrenal Glands; Animals; Body Weight; Brain; Chloroform; Death; Ethanol; Ethers; Heart; Heart Rate; | 1967 |
Pharmacological properties of the isopropyl ester of o-sulfamoyl-benzoic acid.
Topics: Animals; Behavior, Animal; Benzoates; Carbamates; Carisoprodol; Chlordiazepoxide; Chlormezanone; Chl | 1967 |
[Recent data on the vasodilator mechanism of CO2 on the cerebral vessels].
Topics: Animals; Carbon Dioxide; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Electrophy | 1967 |
A comparison of the convulsant activity of procaine and pentylenetetrazol.
Topics: Animals; Anticonvulsants; Chlorpromazine; Dibenzylchlorethamine; Female; Hydroxybutyrates; Mice; Pen | 1967 |
Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA).
Topics: Animals; Flunitrazepam; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Pentobarbital; Rats; Ra | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; | 1983 |
Practical therapeutics: some investigations of the toxic effects of the alkaloids extracted from Strychnos henningsii (Gilg) "muteta".
Topics: Alkaloids; Animals; Guinea Pigs; Humans; Mice; Neuromuscular Junction; Paralysis; Pentobarbital; Pla | 1984 |
Morphine antagonizes pentobarbital-induced anesthesia.
Topics: Anesthesia; Animals; Atropine; Behavior, Animal; Electroencephalography; Male; Morphine; Naloxone; N | 1983 |
Cyclonite poisoning in a dog.
Topics: Acepromazine; Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Ketamine; Male; Pentobarbital; | 1983 |
Differential rearing affects responsiveness of rats to depressant and convulsant drugs.
Topics: Animals; Arousal; Dose-Response Relationship, Drug; Female; Male; Muridae; Pentobarbital; Pentylenet | 1983 |
Comparison of effects of diazepam on barbiturate and on ethanol withdrawal.
Topics: Animals; Behavior, Animal; Cats; Diazepam; Disease Models, Animal; Ethanol; Female; Humans; Male; Pe | 1983 |
Effects of individual variations in drug elimination kinetics for production of pentobarbital physical dependence.
Topics: Animals; Cats; Central Nervous System; Depression, Chemical; Female; Half-Life; Humans; Kinetics; Ma | 1983 |
Should alcohol withdrawal seizures be treated with anti-epileptic drugs?
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Carbamazepine; Chlormethiazol | 1984 |
Excitative effects in anaesthetized rabbits from subarachnoidally injected iso- and hyperosmolar solutions of iohexol and metrizamide.
Topics: Anesthesia; Animals; Contrast Media; Female; Injections; Iodobenzoates; Iohexol; Male; Metrizamide; | 1984 |
Structure-activity relationships of convulsant and anticonvulsant barbiturates: a computer-graphic-based pattern-recognition analysis.
Topics: Anticonvulsants; Barbiturates; Computers; In Vitro Techniques; Models, Molecular; Pentobarbital; Sei | 1983 |
Isoniazid poisoning in a dog.
Topics: Animals; Diazepam; Dog Diseases; Dogs; Fluid Therapy; Isoniazid; Male; Pentobarbital; Seizures | 1982 |
Continuous administration of barbital by pellet implantation.
Topics: Animals; Barbital; Barbiturates; Behavior, Animal; Body Temperature; Body Weight; Drug Implants; Dru | 1980 |
Anesthetic barbiturates in refractory status epilepticus.
Topics: Adult; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Humans; Injections, Intr | 1980 |
A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats.
Topics: Animals; Antipyrine; Autoradiography; Brain; Brain Neoplasms; Cerebrovascular Circulation; Cortical | 1981 |
Behavioral effects following chronic treatment with clomethiazole, pentobarbital and diazepam in the rat.
Topics: Animals; Behavior, Animal; Chlormethiazole; Circadian Rhythm; Diazepam; Hypnotics and Sedatives; Mal | 1981 |
Pharmacological investigation of gamma aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Aminocaproates; Amygdala; Animals; Bicuculli | 1981 |
[Formation of determinant structures and functional complexes in the neocortex when the brain is transected at different levels].
Topics: Animals; Cats; Cerebral Cortex; Cortical Synchronization; Decerebrate State; Electroencephalography; | 1980 |
Factors affecting the development of hyperbaric oxygen toxicity in the awake rat brain.
Topics: Aging; Animals; Brain; Diazepam; Electroencephalography; Hyperbaric Oxygenation; Male; NAD; Pentobar | 1980 |
Distribution of Fos-positive neurons in cortical and subcortical structures after picrotoxin-induced convulsions varies with seizure type.
Topics: Animals; Behavior, Animal; Cell Count; Cerebral Cortex; Coloring Agents; Electroencephalography; Imm | 1995 |
Pharmacodynamic interactions of cypermethrin and centrally acting drugs in mice.
Topics: Acepromazine; Amphetamine; Animals; Central Nervous System Agents; Dipyrone; Drug Interactions; Inse | 1995 |
Central nervous system activity of Rhazya stricta (Decne) in mice.
Topics: Abdomen; Analgesia; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Cimetidine; | 1995 |
Successful treatment of a massive intrathecal morphine overdose.
Topics: Drug Overdose; Electroencephalography; Female; Humans; Injections, Spinal; Middle Aged; Morphine; Pe | 1995 |
Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Diazepam; Ethanol; Female; Flumazenil; Handling, Psycholo | 1994 |
Neurologic and cytologic outcome following repeated ischemia. Effect of pentobarbital.
Topics: Animals; Blood Glucose; Body Temperature; Brain; Cerebrovascular Circulation; Hippocampus; Ischemic | 1994 |
[Central inhibition action of Valeriana jatamansii Jones].
Topics: Analgesics; Animals; Anticonvulsants; Drug Synergism; Drugs, Chinese Herbal; Female; Hypnotics and S | 1994 |
Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal.
Topics: Anesthesia, General; Animals; Ataxia; Barbiturates; Bicuculline; Calcium Channels; Carbolines; Dihyd | 1994 |
Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield.
Topics: Anesthetics; Animals; Biomarkers; Calbindin 2; Cell Death; Chloral Hydrate; Disease Models, Animal; | 1993 |
ECS-induced dopamine release: effects of electrode placement, anticonvulsant treatment, and stimulus intensity.
Topics: Animals; Corpus Striatum; Depressive Disorder; Dopamine; Electric Stimulation; Electroconvulsive The | 1993 |
Anticonvulsant activity of aryl and hetarylsulfonylhydrazones.
Topics: Animals; Anticonvulsants; Body Temperature; Electroshock; Female; Hydrazones; Hypnotics and Sedative | 1995 |
Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice.
Topics: Animals; Behavior, Animal; Catalepsy; Male; Mice; Motor Activity; Pentobarbital; Picrotoxin; Plant E | 1995 |
Pentobarbitone induces Fos in astrocytes: increased expression following picrotoxin and seizures.
Topics: Animals; Antibody Specificity; Astrocytes; Chloride Channels; Convulsants; GABA-A Receptor Antagonis | 1996 |
Evaluation of the calcium-antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia.
Topics: Administration, Oral; Analysis of Variance; Animals; Antidiarrheals; Calcium; Convulsants; Dose-Resp | 1996 |
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Hetero | 1996 |
Polarization anatomy of a kainic acid seizure.
Topics: Adjuvants, Anesthesia; Animals; Brain; Electroencephalography; Excitatory Amino Acid Agonists; Fluor | 1997 |
Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors.
Topics: Animals; Benzodiazepines; Dentate Gyrus; Diazepam; Electric Conductivity; Female; GABA-A Receptor An | 1997 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Fos induction following systemic kainic acid: early expression in hippocampus and later widespread expression correlated with seizure.
Topics: Animals; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; Hypno | 1997 |
Anticonvulsant effects of Magnolia grandiflora L. in the rat.
Topics: Animals; Anticonvulsants; Body Temperature; Electroshock; Ethanol; Ether; Hypnotics and Sedatives; M | 1998 |
Central inhibitory effects of water extract of Acori graminei rhizoma in mice.
Topics: Animals; Apomorphine; Central Nervous System; Dose-Response Relationship, Drug; Drugs, Chinese Herba | 1998 |
Pharmacological characterization of 6-bromo-3'-nitroflavone, a synthetic flavonoid with high affinity for the benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Flavonoids; GABA-A Receptor Agonists; Male; Maze L | 1998 |
Removal of superficial inhibition releases hyperexcitability in middle and deep horizontal slices from rat somatosensory neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dantrolene; Electric Stimulation; Excitatory Amino Ac | 1998 |
Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Drug Interactions; Enzyme In | 1999 |
Genetic determinants of severity of acute withdrawal from diazepam in mice: commonality with ethanol and pentobarbital.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Diazepam; Ethanol; Hypnotics and S | 1999 |
Neuronal activity and stress differentially regulate hippocampal and hypothalamic corticotropin-releasing hormone expression in the immature rat.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Cold Temperature; Corticotropin-Releasing | 2000 |
Neuropharmacological actions of some binuclear lanthanide(III) complexes.
Topics: Animals; Atropine; Convulsants; Defecation; Diazepam; Lethal Dose 50; Metals, Rare Earth; Mice; Mode | 2001 |
Genomewide search for epistasis in a complex trait: pentobarbital withdrawal convulsions in mice.
Topics: Animals; Chromosome Mapping; Crosses, Genetic; Epistasis, Genetic; Female; Male; Mice; Mice, Inbred | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; | 2001 |
Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse.
Topics: Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Male; Mice; Neuromuscular Disease | 1979 |
Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats.
Topics: Acid-Base Equilibrium; Animals; Arteries; Bicuculline; Cats; Chloralose; Dose-Response Relationship, | 1979 |
Proceedings: Influence of pentobarbital on cortical penicillin focus in rats.
Topics: Animals; Electroencephalography; Penicillins; Pentobarbital; Rats; Seizures | 1975 |
Functions of primary afferents and responses of extracellular K+ during spinal epileptiform seizures.
Topics: Action Potentials; Animals; Cats; Extracellular Space; Membrane Potentials; Neural Inhibition; Neuro | 1976 |
Effect of intraventricular administration of anti-somatostatin gamma-globulin on the lethal dose-50 of strychnine and pentobarbital in rats.
Topics: Animals; gamma-Globulins; Injections, Intraventricular; Lethal Dose 50; Male; Pentobarbital; Rats; S | 1978 |
Focal penicillin epilepsy in an isolated cerebral hemisphere.
Topics: Administration, Topical; Animals; Cats; Cerebral Cortex; Electroencephalography; Epilepsies, Partial | 1978 |
[Changes in the millivolt potential of brain structures during micropolarization influencing trace phenomena].
Topics: Animals; Brain; Cats; Caudate Nucleus; Electric Stimulation; Electrophysiology; Haplorhini; Hippocam | 1979 |
Differential interactions of phenobarbital and pentobarbital with beta-adrenergic mechanisms in vitro and in vivo.
Topics: Action Potentials; Animals; Anura; Bucladesine; Calcium; Cyclic AMP; Dose-Response Relationship, Dru | 1977 |
Regulation of the state of phosphorylation of specific neuronal proteins in mouse brain by in vivo administration of anesthetic and convulsant agents.
Topics: Anesthetics; Animals; Brain; Brain Chemistry; Convulsants; Male; Mice; Nerve Tissue Proteins; Pentob | 1979 |
Role of afferent input of subcortical origin in the genesis of bilaterally synchronous epileptic discharges of feline generalized penicillin epilepsy.
Topics: Afferent Pathways; Animals; Brain Mapping; Cats; Cerebral Cortex; Corpus Callosum; Dominance, Cerebr | 1979 |
Potentiation of lidocaine toxicity by pentobarbital in the dog.
Topics: Animals; Blood Pressure; Dogs; Drug Synergism; Electrocardiography; Female; Lidocaine; Male; Pentoba | 1979 |
Hippocampal afterdischarges and their post-ictal sequelae in rats: a potential tool for assessment of CNS neurotoxicity.
Topics: Animals; Behavior, Animal; Electroencephalography; Female; Hippocampus; Male; Pentobarbital; Rats; S | 1979 |
Evaluation of anticonvulsants in barbiturate withdrawal.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cats; Dimethadione; Female; Humans; Male; Pentobarbital; | 1977 |
Barbiturate withdrawal syndrome in cats.
Topics: Animals; Behavior, Animal; Cats; Depression, Chemical; Humans; Motor Activity; Pentobarbital; Seizur | 1977 |
Time course of audiogenic seizure susceptibility and plasma pentobarbital concentration during withdrawal.
Topics: Acoustic Stimulation; Animals; Electroencephalography; Humans; Male; Pentobarbital; Rats; Seizures; | 1978 |
The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroenc | 1977 |
Antiextensor effects of 3,3-diphenyl-n-propylamine in the mouse.
Topics: Animals; Barbital; Behavior, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity | 1978 |
The effect of progesterone on the spontaneous interictal spike evoked by the application of penicillin to the cat's cerebral cortex.
Topics: Animals; Blood Pressure; Castration; Cats; Dose-Response Relationship, Drug; Female; Penicillins; Pe | 1978 |
A model for the rapid induction of barbiturate tolerance.
Topics: Animals; Barbital; Barbiturates; Brain; Drug Tolerance; Lethal Dose 50; Mice; Pentobarbital; Pentyle | 1978 |
Dissociation between the anticonvulsant action of alcohol and its depressant action in mice of different genotypes.
Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Ethanol; Flurothyl; Mice; Mice, Inbred | 1978 |
Results of the use of a new water-soluble contrast medium (metrizamide) in the posterior fossa of the baboon.
Topics: Animals; Electrocardiography; Electroencephalography; Haplorhini; Injections, Intraventricular; Iodo | 1975 |
Pentylenetetrazol-induced amnesia: a case for overt seizures.
Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Humans; | 1976 |
Sulfolane-induced convulsions in rodents.
Topics: Administration, Oral; Animals; Cyclic S-Oxides; Dogs; Drug Interactions; Guinea Pigs; Haplorhini; In | 1976 |
Responses of biosystems to chronic microwave exposure.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Brain; Chlorpromazine; Circadian Rhythm; Conditioning, Clas | 1977 |
Seizures and related epileptiform activity in hippocampus transplanted to the anterior chamber of the eye I. Characterization of seizures, interictal spikes, and synchronous activity.
Topics: Animals; Anterior Chamber; Cerebellum; Cobalt; Diazepam; Electric Stimulation; Evoked Potentials; Fe | 1977 |
Pentobarbital, diazepam and bemegride: their effects on open-field behavior in the gerbil (Meriones unguiculatus).
Topics: Animals; Behavior, Animal; Bemegride; Body Temperature; Diazepam; Drug Interactions; Female; Gerbill | 1977 |
[Role of hyperactive determinant structures in the creation of functional complexes of seizure activity in the cerebral cortex].
Topics: Animals; Cats; Electrophysiology; Frontal Lobe; Pentobarbital; Seizures; Strychnine | 1977 |
Effects of anesthesia and cranial electrode implantation on seizure susceptibility in the cat.
Topics: Animals; Cats; Electrodes, Implanted; Monomethylhydrazine; Pentobarbital; Reaction Time; Research De | 1977 |
Interaction of central nervous system effects of high pressures with barbiturates.
Topics: Animals; Atmosphere Exposure Chambers; Atmospheric Pressure; Barbital; Barbiturates; Female; Mice; P | 1977 |
Carbamazepine pharmacokinetics in young, adult and pregnant rats. Relation to pharmacological effects.
Topics: Aging; Animals; Carbamazepine; Electroshock; Female; Kinetics; Male; Maternal-Fetal Exchange; Pentob | 1976 |
A method for bioassay of physical dependence on sedative drugs in dog.
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Humans; Hypnotics and Sedatives; Methaqualone; Pentobar | 1976 |
Determination of halothane-induced sleeping time in the rat: effect of prior administration of centrally active drugs.
Topics: Animals; Bemegride; Brain Chemistry; Circadian Rhythm; Drug Interactions; Female; Halothane; Injecti | 1976 |
Biochemorphology of cyclobutanecarbonylureas.
Topics: Animals; Cyclobutanes; Drug Synergism; Female; Hypnotics and Sedatives; Male; Mice; Muscle Relaxants | 1975 |
Orthodromic and antidromic effects of a cortical epileptiform focus on ventrolateral nucleus of the cat.
Topics: Animals; Brain Mapping; Cats; Cerebral Cortex; Electric Stimulation; Membrane Potentials; Neural Inh | 1975 |
A model for the rapid development of dispositional and functional tolerance to barbiturates.
Topics: Animals; Barbiturates; Drug Tolerance; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Microsomes, | 1975 |
Anticonvulsant activity of four oxygenated cannabidiol derivatives.
Topics: Animals; Anticonvulsants; Cannabidiol; Cannabis; Cornea; Depression, Chemical; Electroshock; Male; M | 1975 |
Proceedings: Influence of pentobarbital on cortical epileptogenic focus in rats.
Topics: Animals; Cerebral Cortex; Electroencephalography; Male; Penicillins; Pentobarbital; Rats; Seizures | 1975 |
Amphetamine poisoning in dogs.
Topics: Acepromazine; Amphetamine; Animals; Body Temperature; Dextroamphetamine; Dog Diseases; Dogs; Female; | 1976 |
Acute toxicity of penitrem A in dogs.
Topics: Animals; Ataxia; Blood Cell Count; Diarrhea; Dogs; Enzymes; Female; Liver; Male; Mycotoxins; Pentoba | 1976 |
Amyloid precursor protein mRNA encoding the Kunitz protease inhibitor domain is increased by kainic acid-induced seizures in rat hippocampus.
Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Gene Expression Regulation; Hippocampu | 1992 |
Effects of pentobarbital tolerance and dependence on convulsant and GABAA receptor antagonist binding.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Co | 1992 |
Selective antagonism of acute ethanol-induced motor disturbances by centrally administered Ro 15-4513 in mice.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Electrodes, Implanted; Ethanol; | 1992 |
Inhibitory influence of morphinans on ictal and interictal EEG changes induced by cortical application of penicillin in rabbits: a comparative study with NMDA antagonists and pentobarbitone.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Dizocilpine Maleate; Electroencephalography; Injections; | 1992 |
Interaction of pregnanolone and pregnenolone sulfate with ethanol and pentobarbital.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Mice; | 1992 |
Bidirectional contingent cross tolerance between the anticonvulsant effects of pentobarbital and ethanol.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Drug Tolerance; Electric Stimulation; Electrodes, Implant | 1992 |
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentobarbital; | 1992 |
Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats.
Topics: Aminophylline; Anesthesia; Animals; Anticonvulsants; Carbamazepine; Consciousness; Diazepam; Electro | 1992 |
Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid.
Topics: Animals; Blotting, Northern; Brain; Brain-Derived Neurotrophic Factor; Female; Hippocampus; Histocyt | 1992 |
Does glycine antagonism underlie the excitatory effects of methohexitone and propofol?
Topics: Anesthesia, General; Animals; Bicuculline; Central Nervous System; Electroencephalography; Ethanol; | 1992 |
GABA/BZ-and NMDA-receptor interaction in digoxin-induced convulsions in rats.
Topics: Animals; Baclofen; Diazepam; Digoxin; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Injectio | 1991 |
Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diaz | 1991 |
Acute dependence on depressant drugs is determined by common genes in mice.
Topics: Acetaldehyde; Animals; Butanols; Ethanol; Injections, Intraperitoneal; Male; Mice; Pentobarbital; Se | 1991 |
Effect of an anticholinesterase compound on the ultrastructure and function of the rat blood-brain barrier: a review and experiment.
Topics: Animals; Blood-Brain Barrier; Brain; Cholinesterase Inhibitors; Diazepam; Hexamethonium Compounds; H | 1991 |
Effect of subacute insecticide exposure on body weight, drug responses & electrical convulsions in mice.
Topics: Animals; Body Weight; Chlorpromazine; Drug Interactions; Insecticides; Male; Mice; Mice, Inbred Stra | 1990 |
Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract.
Topics: Amphetamines; Animals; Apomorphine; Behavior, Animal; Electroshock; Female; India; Male; Pentobarbit | 1990 |
[Acetylcholinesterase activity in blood plasma and various regions of the central nervous system of rats poisoned with lindane. Effect of sodium pentobarbital].
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Hexachlorocyclohexan | 1985 |
Spontaneous EEG spikes in the normal hippocampus. V. Effects of ether, urethane, pentobarbital, atropine, diazepam and bicuculline.
Topics: Anesthetics; Animals; Atropine; Behavior, Animal; Bicuculline; Diazepam; Electroencephalography; Eth | 1988 |
Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Respons | 1989 |
Interaction between GABAergic anticonvulsants and the NMDA receptor antagonist MK 801 against MES- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Electroshock; Ethanol | 1989 |
[Anticonvulsive properties of peptide ACTH4-7 pro-gly-pro detected in amygdaloid kindling and audiogenic epilepsy in rats].
Topics: Acoustic Stimulation; Adrenocorticotropic Hormone; Amygdala; Animals; Anticonvulsants; Delayed-Actio | 1989 |
Effects of the gut-stimulating principle in Croton penduliflorus seed oil on the central nervous system.
Topics: Analgesia; Animals; Arachidonic Acids; Central Nervous System; Croton Oil; Endorphins; Female; Gastr | 1989 |
Sensitivity to the anticonvulsant effects of ethanol and pentobarbital in mouse lines genetically selected for ethanol sensitivity.
Topics: Animals; Anticonvulsants; Electroshock; Ethanol; Female; Mice; Pentobarbital; Seizures; Species Spec | 1989 |
RO15-4513 but not FG-7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats.
Topics: Affinity Labels; Animals; Appetite Depressants; Azides; Benzodiazepines; Bicuculline; Carbolines; Et | 1989 |
Induction of physical dependence on pentobarbital by new infusion method in the rat.
Topics: Animals; Behavior, Animal; Drug Tolerance; Female; Infusion Pumps; Infusions, Intravenous; Male; Pen | 1989 |
Changes in benzodiazepine/GABA receptor complex function in benzodiazepine-tolerant mice.
Topics: Animals; Anticonvulsants; Bicuculline; Body Temperature; Drug Tolerance; Flurazepam; gamma-Aminobuty | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazole | 1988 |
Antagonizing the anticonvulsant effect of ethanol using drugs acting at the benzodiazepine/GABA receptor complex.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Benzodiazepinones; Carbolines; Convulsants; Dose- | 1988 |
Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Drug Interactions; Electroshock; Ethanol; | 1985 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; M | 1985 |
An investigation on the mechanism of anticonvulsant action of ketamine and phencyclidine on convulsions due to cortical application of penicillin in rabbits.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Ketamine; Male; Penicillins; Pentobarbit | 1985 |
Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; M | 1986 |
Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Bicuculline; Electroshock; Male; Muscim | 1986 |
Mapping patterns of c-fos expression in the central nervous system after seizure.
Topics: Animals; Brain Chemistry; Diazepam; DNA-Binding Proteins; Fluorescent Antibody Technique; Gene Expre | 1987 |
Effects of solvent mixtures on behaviour and seizure characteristics at the utmost additive.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Drug Combinations; Electric Stimulation; Male; Mice | 1988 |
Use of pentobarbital sodium to reduce seizures in dogs after cervical myelography with metrizamide.
Topics: Anesthesia, General; Animals; Body Weight; Dog Diseases; Dogs; Halothane; Metrizamide; Myelography; | 1987 |
Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
Topics: Action Potentials; Animals; Behavior, Animal; Diazepam; Electroshock; gamma-Aminobutyric Acid; Hippo | 1986 |
Cholinergic induction of seizures in the rat prefrontal cortex.
Topics: Animals; Carbachol; Cerebral Cortex; Clonazepam; Diazepam; Electroencephalography; Male; Microinject | 1986 |
Effect of dosing frequency on the development of physical dependence and tolerance to pentobarbital.
Topics: Animals; Cats; Central Nervous System; Drug Administration Schedule; Drug Tolerance; Female; Half-Li | 1986 |
GABAergic influences on barbital withdrawal induced convulsions.
Topics: Animals; Barbital; Barbiturates; Corpus Striatum; gamma-Aminobutyric Acid; Male; Pentobarbital; Rats | 1986 |
[General anesthesia for sismotherapy. The value of a cerebral function monitor].
Topics: Anesthesia, General; Brain; Depressive Disorder; Electroconvulsive Therapy; Humans; Monitoring, Phys | 1986 |
Induction of ornithine decarboxylase as a possible mediator of seizure-elicited changes in genomic expression in rat hippocampus.
Topics: Adrenalectomy; Animals; Enkephalins; Hippocampus; Kinetics; Male; Ornithine Decarboxylase; Pentobarb | 1986 |
Anaesthetic control for metaldehyde poisoning.
Topics: Acetaldehyde; Animals; Dog Diseases; Dogs; Molluscacides; Pentobarbital; Seizures | 1986 |
[Pharmacological action of 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrolinone hydrochloride (doxapram). 1. The action on the central nervous system].
Topics: Amides; Animals; Atropine; Blood Pressure; Central Nervous System; Central Nervous System Stimulants | 1973 |
Neuro-pharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class.
Topics: Aggression; Amphetamine; Animals; Anti-Anxiety Agents; Avoidance Learning; Carbamates; Chlordiazepox | 1974 |
Reactivity of penicillin-induced epileptogenic foci to selective blockade of membrane sodium-potassium ATPase via ouabain.
Topics: Adenosine Triphosphatases; Animals; Biological Transport, Active; Caffeine; Cats; Cell Membrane; Ele | 1974 |
A particular pharmacological effect on the propagation of experimental strychnine and penicillin epilepsy.
Topics: Acetates; Animals; Anticonvulsants; Cerebral Cortex; Chlorpromazine; Electroencephalography; Electro | 1969 |
Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia.
Topics: Animals; Brain; Cell Membrane; Cyclic AMP; Electroshock; Ethyl Ethers; Fatty Acids, Nonesterified; H | 1971 |
Synthesis of substituted piperidino carbamides: correlation between CNS effects and selective inhibition of NAD-dependent oxidations.
Topics: Amides; Animals; Anticonvulsants; Brain; Drug Synergism; In Vitro Techniques; Ketoglutaric Acids; Le | 1974 |
Pulmonary changes with convulsions induced by drugs and oxygen at high pressure.
Topics: Amino Alcohols; Animals; Central Nervous System Stimulants; Chlorpromazine; Curare; Dibenzylchloreth | 1966 |
[Pharmacological studies on 2-methyl-4-amino-6-methoxy-s-triazine (CV399); with special reference to its central effects].
Topics: Amphetamine; Analgesics; Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Body Tempera | 1970 |
An examination of the role of gamma-aminobutyric acid (GABA) in hyperbaric oxygen-induced convulsions in the rat. I. Effects of increased gamma-aminobutyric acid and protective agents.
Topics: Acetates; Aminobutyrates; Animals; Brain Chemistry; Disulfiram; Female; Hydrazines; Hydroxylamines; | 1974 |
Control of convulsions by intralingual administration of barbiturates.
Topics: Animals; Dogs; Female; Injections; Injections, Intramuscular; Injections, Intravenous; Male; Pentoba | 1972 |
Relationship between CNS depressant activity and selective enzyme inhibition by quinazolone salicylhydrazide derivatives.
Topics: Animals; Anticonvulsants; Brain; Drug Synergism; Electroconvulsive Therapy; Hydrazines; Hypnotics an | 1973 |
[Fever convulsions].
Topics: Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Fever; Humans; Long-Term Care; | 1972 |
Effects of pharmacological agents on acoustic priming of audiogenic seizures.
Topics: Acetates; Aminobutyrates; Animals; Brain Chemistry; Chlorpromazine; Hearing Loss, Noise-Induced; Mic | 1972 |
Canscora decussata (Gentianaceae) xanthones. 3. Pharmacological studies.
Topics: Amphetamine; Animals; Anura; Behavior, Animal; Bile; Blood Pressure; Diuresis; Dogs; Drug Interactio | 1972 |
Some psychopharmacological actions of Stephania glabra (Roxb) Miers: an Indian indigenous herb.
Topics: Alkaloids; Analgesia; Animals; Body Temperature; Conditioning, Classical; Dextroamphetamine; India; | 1972 |
Water-soluble contrast medium myelography in the experimental animal. A preliminary report.
Topics: Anesthesia, Intravenous; Animals; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Injections, Spi | 1972 |
Seizures in rats induced by pinealectomy: influence of diazepam, chlordiazepoxide, diphenylhydantoin and pineal substances.
Topics: Animals; Calcium; Chlordiazepoxide; Diazepam; Gluconates; Indoles; Male; Melatonin; Parathyroid Glan | 1973 |
Attenuation of hypothermic retrograde amnesia produced by pharmacologic blockage of brain seizures.
Topics: Amnesia; Amygdala; Animals; Avoidance Learning; Body Temperature; Cold Temperature; Electroencephalo | 1973 |
Neuro pharmacological studies on propranolol--a beta adrenergic blocking agent.
Topics: Analgesics; Animals; Columbidae; Motor Activity; Pentobarbital; Propranolol; Rats; Seizures; Sleep; | 1973 |
Anticonvulsant activity of benziminazoles.
Topics: Amphetamine; Animals; Benzimidazoles; Female; Male; Mice; Pentobarbital; Rats; Seizures; Sleep; Thio | 1973 |
Neuropharmacological study of prostaglandin (PG)F2a.
Topics: Analgesia; Animals; Body Temperature; Cerebral Ventricles; Escape Reaction; Injections; Motor Activi | 1973 |
Behavioral and physiological studies of a convulsing mutant chicken (Gallus domesticus).
Topics: Acoustic Stimulation; Age Factors; Animals; Behavior, Animal; Body Temperature; Body Weight; Chicken | 1974 |
Differentiating stimulus and storage hypotheses of state-dependent learning.
Topics: Animals; Avoidance Learning; Behavior, Animal; Discrimination Learning; Electroshock; Generalization | 1974 |
Spontaneous cure of limbic system epilepsy in the cat.
Topics: Aluminum; Animals; Behavior, Animal; Cats; Cobalt; Electroencephalography; Limbic System; Pentobarbi | 1968 |
Pressure reversal of anaesthesia.
Topics: Alcohols; Anesthesia, General; Anesthetics; Animals; Cell Membrane Permeability; Chemical Phenomena; | 1971 |
Local anesthetic seizure prevention: diazepam versus pentobarbital.
Topics: Anesthesia, Local; Animals; Arousal; Cats; Central Nervous System; Diazepam; Electroencephalography; | 1972 |
An investigation of the pharmacological properties of homocarnosine.
Topics: Aminobutyrates; Animals; Barbiturates; Blood Pressure; Brain Stem; Central Nervous System; Cerebral | 1972 |
Effects of excitation and anaesthesia on the glutamine content of the rat brain with a reference to the administration of glutamine.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Delirium; Glutamates; Glutamine; Head; Huma | 1972 |
Possible mechanism of the prevention of digitoxin toxicity by spironolactone in the mouse.
Topics: Animals; Digitoxin; Drug Antagonism; Enzyme Induction; Liver; Male; Mice; Paralysis; Pentobarbital; | 1971 |
State-dependent learning in rats induced by kindled convulsions.
Topics: Amnesia; Amygdala; Animals; Avoidance Learning; Conditioning, Psychological; Dissociative Disorders; | 1971 |
A comparison of state dependent learning induced by electroconvulsive shock and pentobarbital.
Topics: Amnesia; Animals; Conditioning, Psychological; Discrimination Learning; Dose-Response Relationship, | 1971 |
Emergency submental injection.
Topics: Anesthesia, Dental; Emergencies; Epinephrine; Humans; Injections; Pentobarbital; Procaine; Seizures | 1967 |
Effects of acute and chronic exposure to DDT and of DDT-drug interactions on experimental seizure responses.
Topics: Animals; Central Nervous System; DDT; Dieldrin; Electroshock; Female; Injections, Subcutaneous; Intu | 1970 |
Neural mechanisms of the chloralose jerk with special reference to its relationship with the spino-bulbo-spinal reflex.
Topics: Anesthesia, Intravenous; Animals; Brain Stem; Cats; Chloralose; Electric Stimulation; Electromyograp | 1967 |
Pharmacological study of 1-(beta-phenylethyl) triazolo (4,5-c) pyridine hydrochloride, a tranquillizing agent.
Topics: Aggression; Analgesia; Anesthesia; Animals; Anticonvulsants; Autonomic Nervous System; Avoidance Lea | 1967 |
The convulsive action of 2,5-dicarbethoxy 3,4-dihydroxythiophane (dicetol).
Topics: Acetylcholine; Animals; Blood Pressure; Brain Chemistry; Cats; Depression, Chemical; Guinea Pigs; He | 1968 |
Pharmacological actions of berberine on the central nervous system.
Topics: Alkaloids; Amphetamine; Analgesics; Animals; Anticonvulsants; Cats; Central Nervous System; Drug Syn | 1970 |
Effects of DDT and of drug-DDT interactions on electroshock seizures in the rat.
Topics: Animals; Central Nervous System; DDT; Drug Antagonism; Drug Synergism; Electroshock; Female; Pentoba | 1970 |
Effects of various conditions on the movement of carbon atoms derived from glucose into and out of protein in rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Cerebral Cortex; | 1970 |
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; | 1970 |
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.
Topics: Aggression; Animals; Chlordiazepoxide; Diazepam; Electroshock; Exploratory Behavior; Humans; Locomot | 1970 |
Convulsions induced by 2-N-Di-n-butylaminoethanol.
Topics: Acetylcholine; Amino Alcohols; Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; | 1970 |
Anticonvulsant drugs and self-stimulation rates in rats.
Topics: Acetazolamide; Animals; Chlordiazepoxide; Electrodes; Male; Meprobamate; Pentobarbital; Pentylenetet | 1970 |
Protein-bound amide groups in brain.
Topics: Amides; Ammonia; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Glucose; Glut | 1970 |
Dose reduction factor for radiation lethality in mice as a function of the dose of mercaptoethylamine.
Topics: Animals; Body Temperature; Injections, Intraperitoneal; Injections, Intravenous; Mercaptoethylamines | 1970 |
A study of the excitatory effects of barbiturates.
Topics: Animals; Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Injections, Intravenous; Male | 1970 |
Hypnotic activity of centrally--administered barbiturate and uncouplers of oxidative phosphorylation.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Central Nervous System; Cerebral Ventricles; D | 1970 |
Water intoxication secondary to oxytocin.
Topics: Abortion, Induced; Adult; Female; Humans; Oxytocin; Pentobarbital; Potassium; Pregnancy; Seizures; S | 1970 |
The pharmacology and toxicology of midaflur.
Topics: Analgesics; Animals; Appetite; Avoidance Learning; Benzimidazoles; Body Temperature; Body Weight; Ca | 1971 |
Sound-induced convulsions: latency and severity in unilaterally audiosensitized mice.
Topics: Anesthesia; Animals; Electroshock; Ethers; Hearing; Hypersensitivity; Mice; Pentobarbital; Seizures; | 1971 |
Neuropharmacological comparison of subcortical actions of anticholinergic compounds.
Topics: Animals; Atropine; Benzilates; Diencephalon; Evoked Potentials; Hallucinogens; Mesencephalon; Muscle | 1968 |
Certain aspects of pharmacological profiles of chlordiazepoxide and diazepam.
Topics: Analgesics; Animals; Benzazepines; Chlordiazepoxide; Diazepam; Drug Antagonism; Drug Synergism; Elec | 1968 |
Studies on Withania ashwagandha Kaul. VI. The effect of the alkaloidal fractions (acetone, alcohol and water soluble) on the central nervous system.
Topics: Acetone; Alkaloids; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Drug Synerg | 1968 |
Toxicity of methylimidazoles.
Topics: Animals; Anticonvulsants; Chickens; Chlordiazepoxide; Electroencephalography; Heart Rate; Imidazoles | 1969 |
Experimental seizure-threshold testing with fluorthyl.
Topics: Age Factors; Animals; Body Weight; Diet; Electroshock; Ethers; Female; Fluorine; Guinea Pigs; Male; | 1969 |
The effect of pentobarbital on alcohol withdrawal in dogs.
Topics: Animals; Dogs; Ethanol; Female; Humans; Male; Pentobarbital; Psychoses, Alcoholic; Seizures; Substan | 1969 |
Metabolism and the protection by anesthesia against toxicity of O2 at high pressure.
Topics: Animals; Antidotes; Dinitrophenols; Electric Stimulation; Hyperbaric Oxygenation; Lung; Metabolism; | 1965 |
The rapid development of physical dependence on barbiturates.
Topics: Animals; Cats; Denervation; Humans; Pentobarbital; Pentylenetetrazole; Seizures; Substance Withdrawa | 1965 |
Influence of anesthesia and CO2 on CNS and pulmonary effects of O2 at high pressure.
Topics: Animals; Carbon Dioxide; Central Nervous System; Chloralose; Hyperbaric Oxygenation; Lung; Oxygen; P | 1966 |
The synthesis and pharmacologic evaluation of a series of 8-alkylthio-thiated theophyllines.
Topics: Animals; Central Nervous System; Chemistry, Organic; Diuresis; Heart Rate; Intestines; Male; Muscle, | 1966 |
[Unexpected recovery of a chronic experimental epilepsy].
Topics: Amygdala; Animals; Brain; Brain Stem; Cats; Cerebral Cortex; Chronic Disease; Cobalt; Electroencepha | 1966 |